Abstract: A surgical access assembly includes a housing, a tubular member, and a valve assembly. The tubular member extends from the housing. The valve assembly is positioned in the housing and includes a centering mechanism, a guard assembly disposed on a first side of the centering mechanism, and an instrument seal disposed on a second side of the centering mechanism. The instrument seal including petals that are arrange in an overlapping arrangement.

Abstract: An integrated catheter assembly includes a housing member, an outer lumen member extending from the housing member, and a needle member having a needle slidably or movably coupled to the housing member, wherein the needle can be extended beyond the outer lumen. Once a flash of blood is confirmed the needle member is uncoupled from the housing member and removed from within the patient's vein or artery. A non-removable inner lumen member is connected to the housing member. The distal end of the outer lumen is sealed against the distal end of the inner lumen and includes at having at least one aperture to transfer blood out of the patient to the dialysis machine. The integrated catheter assembly therefore receives and delivers blood through a single injection site.

Abstract: The invention relates to a puncturing system comprising an outer tubular body which is designed to remain in a body part of a living being, characterized in that the puncturing system has at least one inner tubular body and a puncturing needle, wherein the inner tubular body is guided through a working lumen of the outer tubular body and can be longitudinally displaced with respect to the outer tubular body, and the puncturing needle is guided through a puncture lumen of the inner tubular body and the inner tubular body can be longitudinally displaced with respect to the puncturing needle, wherein, after a body part has been punctured by means of a puncturing section of the puncturing needle, which protrudes out of a patient-side end of the puncturing system, the inner tubular body can be moved out of the patient-side end of the catheter at least partially out of the outer tubular body, and is thereby designed to accommodate the puncturing section of the puncturing needle, which protrudes out of the patient-s

Abstract: A catheter assembly may include a catheter adapter. A body of the catheter adapter may include a distal end, a proximal end, and a first lumen extending through the distal end and the proximal end. The catheter adapter may include a side port, which may extend outwardly from the body. The side port may include a second lumen, which may be perpendicular to the first lumen. The catheter assembly may include a catheter extending distally from the distal end of the body. The catheter assembly may include a valve disposed within the first lumen. The valve may include an outer surface that is cylindrical and may seal the first lumen from the second lumen. The catheter assembly may include a divider disposed with the second lumen. The divider may divide the second lumen into a plurality of openings and may increase a burst value of the valve.

Abstract: An intravenous therapy system may include a housing to house an actuation hub, the actuation hub comprising; a needle hub operatively coupled to a needle to insert the needle into a patient's body; and a catheter hub operatively coupled to a catheter to insert the catheter into a patient's body, the catheter being formed coaxially with an outer surface of the needle; and an inflatable bladder formed along a length of the catheter to maintain the catheter in the patient's body.

Abstract: A surgical access assembly includes a housing, a tubular member, and a valve assembly. The tubular member extends from the housing. The valve assembly is positioned in the housing and includes a centering mechanism, a guard assembly disposed on a first side of the centering mechanism, and an instrument seal disposed on a second side of the centering mechanism. The instrument seal including petals that are arrange in an overlapping arrangement.

Abstract: Disclosed herein are sealing devices configured for improving sealing functionality with an engaged extension member of an apparatus. More specifically, disclosed herein are trocar sealing devices configured for improving insufflation gas containment in relation to trocars (and/or other related type of devices) that are used for enabling a surgical instrument such, for example, a laparoscope, to gain access to an abdominal cavity (or other body cavity). By providing for such improved insufflation gas containment, sealing devices as disclosed herein are particularly advantageous, desirable and useful in view of long-standing reasons for limiting insufflation gas leakage and in view of newly recognized reasons stemming from outbreak of COVID-19 disease for limiting insufflation gas leakage.

Abstract: A retractor/protector suitable for use in a surgical incision or a natural orifice comprises a longitudinal axis defining an instrument access channel extending from a proximal end to a distal end; a flexible outer ring; an inner ring; a flexible sheath extending between the outer ring and the inner ring; and at least one rigid segment adapted to attach to the flexible outer ring to thereby increase the rigidity of the outer ring. Embodiments of the retractor/protector are described that have interlocking and non-interlocking rigid segments. Embodiments are also described that have bases that insert into or under the flexible outer ring in addition to or in lieu of rigid segments to increase rigidity and/or provide support for a detachable cap.

Abstract: Catheter assemblies may include introducer needles having a notch or similar structure that allows flashback blood to enter the annular space between a catheter tube and an introducer needle of an IV catheter. The presence of flashback blood in this annular space can provide a clinician with an early, visible indication that a needle has entered a vein. The notch, however, may create a leak path for blood to escape outside of the catheter assembly, unless contained. Disclosed herein is a notch containment that prevents the notch from providing a leak path for blood to escape outside of the catheter during or after needle withdrawal.

Abstract: Some embodiments described herein provide for a number of portable infusion pumps to be distributed to a pump user via a pharmacy system or like.

Abstract: A catheter assembly may include a catheter adapter. A body of the catheter adapter may include a distal end, a proximal end, and a first lumen extending through the distal end and the proximal end. The catheter adapter may include a side port, which may extend outwardly from the body. The side port may include a second lumen, which may be perpendicular to the first lumen. The catheter assembly may include a catheter extending distally from the distal end of the body. The catheter assembly may include a valve disposed within the first lumen. The valve may include an outer surface that is cylindrical and may seal the first lumen from the second lumen. The catheter assembly may include a divider disposed with the second lumen. The divider may divide the second lumen into a plurality of openings and may increase a burst value of the valve.

Abstract: A cover for a probe head of an air data probe includes a sleeve defining a cavity for enclosing a portion of the probe head of the air data probe, the sleeve including a closed end, an open end opposite the closed end, and an interior surface extending from the open end to the closed end, and a reservoir for holding insect repellent, the reservoir located at least partially within the cavity of the sleeve.

Abstract: A bone marrow access apparatus is adapted to be installed in connection with a bone. The bone marrow access apparatus includes a bone penetrating member having an internal channel having an opening at a proximal end and an opening at a distal end adapted to open into in a bone marrow space in the bone. A valve cap is provided around part of the bone penetrating member, and includes a valve having an opening having an open state in which the channel is not obstructed and a closed state to prevent flow of a material through the channel.

Abstract: The present disclosure relates to cannula assemblies for use with robotic surgical systems. According to an aspect of the present disclosure, a surgical cannula assembly for use with a mounting structure of a robotic arm, is provided. The surgical cannula assembly includes a cannula configured for reception of a surgical instrument at least partially therethrough; an attachment mechanism configured to releasably engage the cannula; and a barrier configured to extend through a channel of the mounting structure. The barrier includes a proximal ring for positioning adjacent a proximal face of the mounting structure, a distal ring for positioning adjacent a distal face of the mounting structure, and a cylindrical section defining a lumen therein and extending between the proximal ring and the distal ring, the cannula configured for insertion within the lumen in a distal-to-proximal direction.

Abstract: The invention discloses a trocar seal membrane with concave-channel structure. Said seal membrane comprises a proximal opening, a distal aperture, and a sealing wall from the distal aperture extending to the proximal opening, said sealing wall comprising a proximal surface and a distal surface, said distal aperture formed by a scaling-lip for accommodating the inserted instrument and formed a gas-tight seal, said sealing-lip comprising a longitudinal axis and a transverse plane substantially perpendicular to said axis. In the lip-adjacent area, said sealing wall comprises the main rotary-wall and a plurality of concave-channel each of the concave-channels includes two side sealing-walls, which are defined by both edges and extending laterally outward from the sealing-lip and gradually widening. Said concave-channels have the functions of enlarging hoop circumference, reducing the wrapped area, improving lubrication reliability, increasing the axial tensile stiffness, etc.

Abstract: A connector for use with a pleural catheter that connects securely a drainage tube to a valve of the plural catheter. A system including a fluid receptacle having a negative fluid pressure, a plural catheter having an end designed for implantation into a pleural space of a subject, and an opposite second end having a valve feature, a drainage tube having an end connected to the fluid receptacle and another end having a connector that securely connects the drainage tube to the valve feature of the catheter.

Abstract: An embolic protection device for use in a patient's blood vessel, such as the aorta, has an approximately cylindrical outer structure made of a filter mesh material and an approximately conical inner structure also made of a filter mesh material. On the downstream end of the embolic protection device, the wider end of the conical inner structure is joined to the cylindrical outer structure. The upstream end of the embolic protection device is open for blood to flow between the conical inner structure and the cylindrical outer structure. The space between the conical inner structure and the cylindrical outer structure defines a collection chamber for captured emboli. The narrow upstream end of the conical inner structure has a catheter port with a resilient seal that is sized for passage of a catheter shaft. The filter mesh material may be self-supporting or it may be supported on a resilient-framework or an inflatable framework.

Abstract: A trocar seal membrane with multi-dimensional pleats. The seal membrane includes a proximal opening, a distal aperture, and a sealing wall from the distal aperture ex-tending to the proximal opening, the sealing wall includes a proximal surface and a distal surface. The distal aperture formed by a sealing lip for accommodating the inserted instrument forms a gas-tight seal. In the lip-adjacent area, the sealing wall simultaneously has a plurality of transverse pleats extending laterally outwardly from the sealing lip and a plurality of tangential pleats uniformly distributed around the sealing lip. The pleated sealing wall can enlarge hoop circumference in the lip-adjacent area, and reduce overall deformation when a large-diameter instrument is inserted, thereby reducing friction and improving sealing reliability.

Abstract: The application relates to an infusion part comprising a cannula part (7) and a fluid path, whereby a sealing (18) is positioned between the cannula part and an inlet/outlet opening (12) of the fluid path when the cannula part is in position for use in order to keep the fluid path to a cannula tight. The sealing (18) is surrounding the inlet/outlet opening (12) and/ or the distance d1 between a centre line c of the cannula part and a point on an outer surface of the cannula part positioned at or above an upper edge of the sealing (18) is larger than the distance d2 between the centre line c of the cannula part and a point on the outer surface of the cannula part positioned at or below a lower edge of the sealing.

Abstract: Connectors for medical devices include visual and tactile features as an indicator of a connection-type of the connector. This allows for differentiation by type of connection under busy and/or low light conditions.

Abstract: Disclosed is a trocar seal membrane and assembly including normal concave-channels and reverse concave-channels. The seal membrane includes a proximal opening, a distal aperture, and a sealing wall from the distal aperture extending to the proximal opening. The distal aperture formed by a sealing lip for accommodating the inserted instrument forms a gas-tight seal. The sealing wall includes a proximal surface and a distal surface. The sealing wall is a seamless sealing body with multiple normal concave-channels and multiple reverse concave-channels surrounding the sealing lip in an alternating manner. The normal concave-channels and reverse concave-channels has the functions of enlarging hoop circumference, reducing the wrapped-area, improving lubrication reliability, increasing the axial tensile stiffness, etc., thereby, the frictional resistance and the stick-slip can be greatly reduced.

Abstract: Disclosed is a seal membrane and assembly including the concave-channel. The seal membrane includes a proximal opening, a distal aperture, and a sealing wall from the distal aperture extending to the proximal opening. The sealing wall includes a proximal surface and a distal surface. The distal aperture is formed by a sealing lip for accommodating the inserted instrument and forming a gas-tight seal. The sealing wall includes a main rotary-wall and multiple concave-channels.

Abstract: A medical connector includes a housing with a central axis, a hollow bore, and a narrowed passage. The connector further includes a rigid valve member configured to move along the axis of the connector as the connector moves between an open and closed configuration. The connector includes a resilient member coupled to the valve member and the housing.

Abstract: The invention relates to a puncturing system comprising an outer tubular body which is designed to remain in a body part of a living being, characterized in that the puncturing system has at least one inner tubular body and a puncturing needle, wherein the inner tubular body is guided through a working lumen of the outer tubular body and can be longitudinally displaced with respect to the outer tubular body, and the puncturing needle is guided through a puncture lumen of the inner tubular body and the inner tubular body can be longitudinally displaced with respect to the puncturing needle, wherein, after a body part has been punctured by means of a puncturing section of the puncturing needle, which protrudes out of a patient-side end of the puncturing system, the inner tubular body can be moved out of the patient-side end of the catheter at least partially out of the outer tubular body, and is thereby designed to accommodate the puncturing section of the puncturing needle, which protrudes out of the patient-s

Abstract: A medical device for delivery of a fluid to a patient from a line terminating in a tubing needle. The medical device includes a cannula assembly for coupling the fluid into a cannula that is inserted into the patient. The cannula assembly has a first locking element disposed in a fixed position with respect to the cannula. Coupling the line to the cannula assembly is an infusion flap. The infusion flap includes a second locking element for engaging the first locking element of the cannula assembly and a lift tab for disconnecting the infusion flap from the cannula assembly. Coupling of the first and second locking elements requires initial mating of the infusion flap and cannula assembly followed by locking through rotation of the infusion flap with respect to the cannula assembly.

Abstract: A connector includes an elastic valve body that includes a top face on which a slit is formed and a bottom face opposite the top face; and a holding section that is in contact with the top face and the bottom face of the elastic valve body and holds the elastic valve body. The holding section surrounds the slit, and the elastic valve body includes a peripheral section that is positioned outward of a portion of the elastic valve body that is held by the holding section. The elastic valve body and the holding section are configured such that a volume of the peripheral section in a state in which the elastic valve body is held by the holding section is larger than a volume of the peripheral section in a state in which the elastic valve body is not held by the holding section.

Abstract: A liquid injection port including a liquid input block defining a liquid input conduit; a compression block adapted to mate with the liquid input block; and a septum including a deformable material mounted in a septum retainer, the septum defining a central perforation, and forming a seal between the liquid input block and the compression block. The septum defines a conical deformation toward the liquid input conduit. A method for delivering fluid from a pipette tip includes a) introducing the fluid into the pipette tip; b) inserting the pipette tip into a pipette conduit defined by a compression block; c) inserting the pipette tip through a septum mounted in the compression block; and d) releasing the fluid in the pipette tip into a liquid input conduit defined in a liquid input block, the septum defining a conical deformation toward the liquid input conduit while maintaining a seal.

Abstract: Catheter systems comprising independent fluid paths are disclosed. The catheter systems can include a catheter adapter that has a catheter hub with a chamber. A catheter extends from a distal end of the catheter hub and is in fluid communication with the chamber. A stabilization platform with a first wing and a soft push tab are also part of the catheter hub. The catheter system includes a needle hub with a needle that slidably fits within the catheter. In an insertion configuration, a proximal extension of the catheter hub is removably coupled within a distal opening of the needle hub. After the catheter is placed, the needle hub is retracted from the catheter adapter to slidably remove the needle from the catheter.

Abstract: An introducer and a delivery assembly for introduction of a prosthesis into a bodily lumen is disclosed. The introducer comprises: a sheath; a housing mounted to a distal end of the sheath, the housing having a passage there-through adapted to receive a delivery assembly; a port for introducing flushing fluid, the port communicating with the passage; and a liquid absorbing seal for sealably receiving the delivery assembly, the liquid absorbing seal disposed within the housing distally of the port. The delivery assembly comprises: a guide wire catheter; a tip mounted to a proximal end of the guide wire catheter; a distal delivery member mounted around the guide wire catheter and located distal of the tip; and a prosthesis receiving portion between the tip and the distal delivery member. The delivery assembly is slidably mounted through the introducer. Absorption of fluid swells the liquid absorbing seal.

Abstract: A catheter assembly including a catheter hub being connectable to a device for the infusion or withdrawal of fluids; a hollow extension tube connected at its distal end to the catheter hub, the extension tube connectable at its proximal end to a device for infusing fluid into the chamber within the catheter hub; a valve assembly disposed within the chamber of the catheter hub having a first valve member and a second valve member preventing the flow of fluid through the chamber to or from the proximal end of the catheter hub. A needle guard assembly is also provided.

Abstract: Hemostasis valves and hemostasis valve assemblies can be coupled to a proximal end of an introducer sheath to prevent blood loss through the proximal end of the introducer sheath. Some hemostasis valve assemblies may include an elastomeric member with a variable-width channel that is designed to form a liquid-tight seal over elongate members of different diameter or a single elongate member of variable diameter.

Abstract: Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.

Abstract: A medical joint and a check valve module thereof are used in a connection tube having a communicating opening. The check valve module includes a first membrane and a second membrane. The first membrane is assembled to the communicating opening to seal the same. The first membrane includes a first slit. The first membrane and the second membrane are disposed overlappingly. The second membrane includes a second slit. Accordingly, it facilitates inserting a detector into the connection tube to detect gas pressure, MDI, gas, temperature, or inserting a suction tube to remove sputum, and prevents the gas inside the connection tube from leaking out from an intersection of a first slit and a second slit, thereby achieving handiness and a gas-leak-proof effect of the medical joint and the check valve module.

Abstract: A catheter assembly including a catheter hub being connectable to a device for the infusion or withdrawal of fluids; a hollow extension tube connected at its distal end to the catheter hub, the extension tube connectable at its proximal end to a device for infusing fluid into the chamber within the catheter hub; a valve assembly disposed within the chamber of the catheter hub having a first valve member and a second valve member preventing the flow of fluid through the chamber to or from the proximal end of the catheter hub. A needle guard assembly is also provided.

Abstract: Methods of quickly and easily implanting a quick-connect heart valve prosthesis during a surgical procedure are provided. The heart valve may include a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A system and method for deployment includes an integrated handle shaft and balloon catheter. A safety member disposed between the balloon catheter and handle shaft prevents premature catheter advancement prior to heart valve placement at the annulus, and also may prevent premature balloon inflation prior to full catheter advancement.

Abstract: The present invention is directed to an automated vessel puncture device, methods of mapping three-dimensional views of subcutaneous vessels and methods for providing simultaneous real-time diagnostic assay.

Abstract: A cannula arrangement includes an outer tube and an inner tube. The outer tube has a proximal end and a distal end. The inner tube is disposed within the outer tube to define a space between an inner surface of the outer tube and an outer surface of the inner tube. A flexible sealing element is sized to seal the space between the inner surface of the outer tube and the outer surface of the inner tube. The flexible sealing element is connected to a proximal portion of the outer tube. The flexible sealing element has a cantilevered portion that longitudinally extends proximally from the proximal end of the outer tube. The cantilevered portion has an inner surface portion that does not contact the inner tube, and a proximal portion configured to define an interior edge to contact the outer surface of the inner tube.

Abstract: A laparoscopic port is disclosed which includes a tubular member comprising a proximal end and a distal end and a lumen extending there between. At least one seal member provided in the lumen adapted to prevent pressurized gas flow from the distal end to the proximal end of the tubular member. The laparoscopic port further includes a shielding trigger positioned distal to the seal member in the lumen, the shielding trigger is shaped so as at least a proximal portion of the shielding trigger has a narrowing cross-section that extends towards the seal member, the proximal portion is adapted to actuate a reversibly opening and protection of the seal member upon a proximally projected pressure from a distal end of an artifact.

Abstract: A surgical access instrument for permitting access to body tissue is presented including a housing having a proximal end and a distal end, and a cannula member connected to the housing, the cannula member defining a longitudinal axis and permitting passage of a surgical object therethrough. The surgical access instrument also includes a sealing member disposed within the housing and including at least one opening therethrough, the sealing member configured to be connected to a plurality of bellows members extending in a vertical plane within the housing. The sealing member is also enabled to be displaced in a horizontal plane with respect to the longitudinal axis defined by the cannula member. Displacement of the sealing member in the horizontal plane is enabled by a roller assembly circumferentially arranged at the proximal end of the housing.

Abstract: The invention concerns a base part for a medication delivery device, the base part comprising a connection part and a moveable part. The moveable part, which moves relative to the connection part, is capable of guiding fluid paths from a medication delivery port to a first cannula or sensor and a second cannula or sensor. The base part also comprises guiding means which can direct each cannula or sensor to its subcutaneous position.

Abstract: A housing may have a needle, plunger, and bias mechanism supported within the housing by a tab configured to retain the plunger in position and to allow the plunger to move under bias force imparted by the bias mechanism to move the needle to an insert position when the tab is removed. A base and a structure may be configured for relative movement there between and may be adapted to be secured to a user with a cannula extending through a body of the structure into the user during use of a medical device. A housing may be adapted to be secured to a user to support a medical device operable with an insertion needle, the housing having a magnifying material for increasing visibility of an injection site.

Abstract: A medical port includes a disc-shaped valve 1 in which an insertion hole is formed in a central portion 1a, a base seat 7 that supports the valve from a lower surface side, and a cover 2 that has a fitting hole exposing an upper surface of the central portion of the valve and covers at least a peripheral edge of the valve from the upper surface side, the fitting hole being formed so that when an inserting body has been inserted into the insertion hole, a fit between the inserting body and the fitting hole can cause the inserting body to be locked against the cover. An annular protrusion 1d is formed in the valve 1, the annular protrusion being continuous in the circumferential direction, and formed in the valve 1 so that in the state in which the inserting body is locked against the cover, the annular protrusion is in contact with an outer circumferential surface of a leading end portion of the inserting body.

Abstract: A system for controlling fluid flow in a catheter assembly is disclosed. The system comprises an intravenous catheter assembly with a catheter adapter. The catheter adapter comprises an inner lumen with a septum disposed within a portion of the inner lumen. The septum has a barrier capable of being deformed from a relaxed position to a biased position. The barrier further comprises a slit having a closed configuration and an opened configuration. The slit is in the closed configuration when the barrier is in the relaxed position and in the opened configuration when the barrier is in the biased position. The barrier is configured to be mechanically deformed from the relaxed position to the biased position by a septum actuator that advances against a proximal surface of the barrier without traversing the barrier.

Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The heart valve may include a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A system and method for deployment includes an integrated handle shaft and balloon catheter. A safety member disposed between the balloon catheter and handle shaft prevents premature catheter advancement prior to heart valve placement at the annulus, and also may prevent premature balloon inflation prior to full catheter advancement.

Abstract: Fluid delivery device includes a body, a cannula adapted to extend into subcutaneous tissue, and a septum member adapted to allow a needle to puncture the septum member and to reseal the puncture once the needle is withdrawn from the puncture. The septum member is at least one of; a cap-shaped member, a member having at least two non-parallel walls that can each be punctured by a needle, and a member having a generally planar wall and a generally cylindrical wall which can each be punctured by a needle.

Abstract: The present invention generally provides methods and devices for removing fluid from a surgical instrument. Surgical access devices and seal systems are generally provided having one or more valves or seal assemblies to create a closed system between the outside environment and the environment in which the surgical access device is being inserted. In one embodiment, a seal assembly is provided and can include a seal having an opening configured to receive a surgical instrument therethrough and a fluid remover in the form of a sorbent element, a scraper element, a wicking element, or any combination thereof can be associated with the seal and configured to remove fluid from the opening and/or a surgical instrument.

Abstract: A catheter assembly including: an inner needle having a sharp tip at a distal end thereof; an inner needle hub connected to a proximal end portion of the inner needle; a catheter through which the inner needle is inserted; a catheter hub connected to a proximal end portion of the catheter; and a protector that covers at least the tip of the inner needle when the inner needle is withdrawn. The protector includes: an inner tube that includes at least one arm that releasably engages with a proximal end of the catheter hub from an outer side of the catheter hub; and an outer tube inside which the inner tube is arranged, and which is capable of being displaced in an axial direction relative to the inner tube.

Abstract: A needleless connector includes a hollow connector, a spring, and a switch assembly. The inner perimeter of the hollow connector forms a first annular wall and a second annular wall. The spring is disposed in the hollow connector. The switch assembly has a stop member and a guide tube connected to the stop member, the stop member being pressed between the annular block and the spring, the guide tube being disposed in the hollow connector, the external perimeter of the stop member forming a first annular portion against the first annular wall and a second annular portion against the second annular wall, a groove being disposed between the first annular portion and the second annular portion of the stop member, the groove being connected to the guide tube. Thus, the integral structure stability and good closing performance are achieved such that the outside air cannot leak into the connector structure.

Abstract: An access assembly is provided.

Abstract: A catheter includes a pressure actuated seal within a manifold. A catheter body is coupled with the manifold, and a manifold lumen and a catheter lumen are configured to receive pressurized fluids. The pressure actuated seal includes a pressure actuated seal element having a seal element lumen. The seal element lumen is in communication with the manifold and catheter lumens. The pressure actuated seal element is deformable between an open configuration and a sealed configuration. In the sealed configuration, the pressurized fluids in the manifold press on the pressure actuated seal element along a first seal face. The pressure actuated seal element compresses inwardly around the seal element lumen according to a pressure of the pressurized fluids. In the open configuration, the pressure actuated seal element relaxes in an absence of the pressurized fluids, and the seal element lumen is open and configured to allow passage of an instrument.