Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a collection vessel by a flexible conduit. The collection vessel can comprise one or more syringe bodies. The syringe bodies are provided with tissue removed from a body using the cannula by a tissue transfer channel. As a result, multiple syringe bodies can be loaded with tissue, without requiring manual handling of that tissue. Alternatively or in addition, a collection bag can be provided for receiving tissue removed from a body using a cannula. The tissue collection bag can include a filter. A collection vessel comprising a collection bag can be used in combination with a collection vessel comprising one or more syringe bodies.

Abstract: A drug delivery system includes an automatic injector that can deliver a small, precise amount of a therapeutic agent. The automatic injector includes a chamber for containing a liquid component and a thin porous member that carries thereon and/or therein the small, precise amount of therapeutic agent. Upon activation of the automatic injector, a flow path opens from the chamber through the porous member, enabling the liquid component to rapidly mix with the therapeutic agent before being injected.

Abstract: The prefilled syringe filled with a drug in advance, leaking of liquid from the cap is prevented, gas barrier properties are given to the whole of the barrel filled with the drug and the shoulder section so that degradation of the drug is prevented, permeation of microbial contaminants is prevented to a high extent, and efficiency of packing as a compact container can be increased. The prefilled syringe includes a guard-shaped extension projecting from the outer periphery of a shoulder section of the syringe barrel on the nozzle side, and a range from a part where a gasket of the plunger is positioned on the outer surface of the syringe barrel filled with the drug to the guard-shaped extension is covered with barrier packaging.

Abstract: Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

Abstract: A single in-line filter hollow needle has an outer wall, a proximal end, a distal end with a pointed tip and a central opening between the ends for communicating fluids therethrough. The proximal end is secured to a luer lock for removable connection to a syringe. A filter is located in the central opening proximate to the tip. The outer wall of the needle has a frangible deformation proximate to the filter and remote from the end of the needle whereby the needle may be broken to expose a fresh point after fluid is aspirated through the needle to the syringe is filtered.

Abstract: Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.

Abstract: The delivery system of the present invention is comprised of at least two chambers which store, individually, an activated blood component and an inactivated blood component. The first chamber comprises an activating agent and a filter which may be one in the same thus allowing the formed clot to be triturated thereby isolating the thrombin from the clot. The second chamber stores the inactivated blood component that when mixed with thrombin will produce a gel. The first or second chamber may further contain agents which are desired to be delivered to a specific site. The unique design of the delivery system allows for ease in operation of combining two agents at a specific time and place.

Abstract: Provided are systems comprising delivery vehicles for the stable storage of immobilized proteins, e.g., protein therapeutics, in a form amenable to administration, such as by injection or infusion, in combination with an elution fluid. Also provided are proteins adsorbed to chromatography media in a form compatible with a one-step administration of the protein. Exemplary delivery vehicles are pre-filled syringes and pre-filled infusion modules; exemplary proteins are antibodies useful in therapy. Also provided are methods of producing the immobilized proteins and methods of using the immobilized proteins, e.g., protein therapeutics.

Abstract: An injection syringe, having a syringe cylinder, a plunger rod inserted therein and connected to a stopper by way of a coupling part, and a module that is provided in the proximal end of the syringe cylinder and having a cannula, mounted in a cannula holder received in a guided sleeve, and a sealing insert for the fluid-tight closure of the proximal end of the syringe cylinder and a protection cap for protecting the cannula, wherein the protective cap on the inner circumference has ribs extending in the axial direction, which engage in corresponding grooves of the driving part for a rotary drive thereof, and wherein in the sealing insert a hollow space is formed, which is closed on the proximal side and on the distal side transitions into an opening, by way of which a tip of the coupling part can be coupled to the hollow space.

Abstract: A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

Abstract: A flow delivery system includes a syringe and a needle and/or a catheter that delivers an aqueous solution of a material, e.g., a biomaterial alone or mixed with a fluid lubricant, into a body. A filter located within the body of the syringe includes a plurality of openings each of a predetermined size. As the solution travels through the syringe, the solution encounters the filter openings which break up or downsize any biomaterial particles larger than the size of the openings. Also, the filter openings allow any particles of the biomaterial originally smaller than the size of the openings to pass without any downsizing. The size of the filter openings is selected as a function of the size of the opening in the needle and/or catheter. The downsized particles then pass with any other non-downsized particles in a relatively unobstructed manner into the body through the needle and/or catheter.

Abstract: Liquid sample collector interface, comprising a cap detachably interlocked with housing, with the cap having a filter chamber that accommodates a filter with a large surface area that extends beyond an end of the filter chamber for easy removal of the filter without the use of tools.

Abstract: A syringe piston used in fat transplantation is structured such that free oil is easily separated from suctioned fat by a syringe piston having a filter and naturally discharged through the rear side thereof. The syringe piston without a shaft, used in fat transplantation, disposed in a syringe-shaped cylindrical vessel, includes a piston body without the shaft, a packing coupled with an outer surface of the piston body to seal between the piston body and the syringe-shaped cylindrical vessel, a free oil discharging hole communicated with the front side and the rear side of the piston body, an opening and closing device for opening and closing the free oil discharging hole, and a filtering device disposed in a passage through which free oil is discharged to filter fat and pass the free oil.

Abstract: A discharge assembly is disclosed which partitions a conventional syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. Incorporated in the discharge assembly is a syringe stopper body and an associated valve stem which in combination form a valve. A syringe plunger communicates through fluid in the proximal chamber to force displacement of the discharge assembly. The valve is actuated by collision between a rigid member which is a part of the valve stem and the distal internal surface of the syringe. The discharge assembly may be made from two parts: (1) the stopper body (made from conventional syringe stopper material); (2) the valve (actuating) stem made from rigid material similar to material from which the syringe barrel is made.

Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a collection vessel by a flexible conduit. The collection vessel can comprise one or more syringe bodies. The syringe bodies are provided with tissue removed from a body using the cannula by a tissue transfer channel. As a result, multiple syringe bodies can be loaded with tissue, without requiring manual handling of that tissue. Alternatively or in addition, a collection bag can be provided for receiving tissue removed from a body using a cannula. The tissue collection bag can include a filter. A collection vessel comprising a collection bag can be used in combination with a collection vessel comprising one or more syringe bodies.

Abstract: An apparatus and method used in a urological procedure. The apparatus includes a sheath capable of insertion into a passageway within a patient. A filter is provided that includes a mesh that retains any particulate matter that is entrained with the liquid and allows the liquid to pass therethrough. The filter may be removeably attached to receive flow from an outlet of the sheath.

Abstract: The present invention relates to a device for delivering a flowable composition comprising cells, wherein the flowable composition is in an amount effective to treat an injured or diseased site. The device comprises a delivery device adapted for minimally-invasive delivery of the flowable composition through which the flowable composition can be passed while maintaining the effectiveness and viability of the cells of the flowable composition. The present invention further relates to a method for delivering the flowable composition comprising cells. The method comprises the steps of percutaneously inserting a delivery device adapted for minimally-invasive delivery of the flowable composition through which the flowable composition can be passed while maintaining the effectiveness and viability of the cells of the flowable composition and administering the flowable composition at, adjacent to or in the vicinity of the injured or diseased site.

Abstract: A syringe includes a needle assembly at least partially secured within a barrel of the syringe, the needle assembly including a needle stem, a resilient member biasing the needle stem toward a proximal end opening of the barrel, a needle holder connectable to the needle stem during assembly of the syringe and that is further securable to a needle, and a cap that is dimensioned to surround the needle secured to the needle holder and a portion of the needle holder during assembly of the needle holder with the needle stem.

Abstract: The prefilled syringe filled with a drug in advance, leaking of liquid from the cap is prevented, gas barrier properties are given to the whole of the barrel filled with the drug and the shoulder section so that degradation of the drug is prevented, permeation of microbial contaminants is prevented to a high extent, and efficiency of packing as a compact container can be increased. The prefilled syringe includes a guard-shaped extension projecting from the outer periphery of a shoulder section of the syringe barrel on the nozzle side, and a range from a part where a gasket of the plunger is positioned on the outer surface of the syringe barrel filled with the drug to the guard-shaped extension is covered with barrier packaging.

Abstract: A flow delivery system including a syringe that includes an outer plastic shell, a leur and a plunger; and a needle and/or a catheter that embodies a hub and a cannula which delivers a solution of a material. Various structures are included to provide locking engagements, torque sensitive connections, sufficient interfacing between components and visual conformation of connectors. The syringe assembly can also include an approach to a filter. Moreover, an approach to sterilization is provided.

Abstract: A sheath (1) is disclosed which is suitable for covering the needle of a syringe (2). The sheath (1) includes a filter (3) which projects partially from the end of the sheath to aid the drawing of liquid into the syringe. It is intended that the needle and/or syringe are sold fitted with the sheath (1) so that there is no need to expose the needle until the user is ready for injection. The invention includes a blister pack (12 FIG. 4) which includes a ready assembled syringe, a mixing pan and paraphernalia for the preparation of the solution to he injected.

Abstract: A syringe having two or more chambers having a needle defining two or more lumens for injecting a microparticle suspension into a desired space, the lumens being in fluid communication with respective chambers. One of the chambers has the microparticle suspension disposed therein while the other chamber is empty. The lumen in fluid communication with the empty chamber has a filter element disposed therein such that the suspension fluid may be withdrawn from the space into the empty chamber without withdrawing the microparticles.

Abstract: The present invention includes a harvesting and irrigation device, a method and a kit for the collection of viable fat cells and/or adipose tissue with decreased handing and improved yield and viability.

Abstract: System and methods for collecting and preparing fat for autologous fat tissue transplantation. The system includes syringes, filtering and transferring assemblies coupled with the syringes, a centrifuge and a centrifuge insert releasably coupled with the centrifuge. Substances, including oil, fat, and denser substances, such as tumescent fluid, connective tissue, hormones and/or other non-fat substances, are harvested through a cannula into a syringe. Syringes are placed in the centrifuge insert, and subject to centrifugation. Centrifugation stratifies the substances into a top oil stratum, a middle fat stratum, and a bottom denser substance stratum. Denser substances are filtered out of the syringes during or after centrifugation. Oil is removed through an aspiration port in the plunger head of the syringe plunger. Fat is transferred from the first syringe into one or more smaller syringes through an adapter in the assembly coupled with the first syringe and the smaller syringe.

Abstract: Sample pipettes used in particular for injecting samples into high pressure liquid chromatography apparatuses, which are provided with a hollow needle for drawing a sample and expelling same into a container or into a sample receiving device of the apparatus. An interchangeable cannula is mounted on the hollow needle of such a pipette, said cannula being capable of containing additional functional elements such as filters, chemically active phases and the like.

Abstract: A syringe piston used in fat transplantation is structured such that free oil is easily separated from suctioned fat by a syringe piston having a filter and naturally discharged through the rear side thereof. The syringe piston without a shaft, used in fat transplantation, disposed in a syringe-shaped cylindrical vessel, includes a piston body without the shaft, a packing coupled with an outer surface of the piston body to seal between the piston body and the syringe-shaped cylindrical vessel, a free oil discharging hole communicated with the front side and the rear side of the piston body, an opening and closing device for opening and closing the free oil discharging hole, and a filtering device disposed in a passage through which free oil is discharged to filter fat and pass the free oil.

Abstract: The device comprises a container with a manually displaceable plunger, the container being extended, forming an integral assembly, on a connection piece and a tubular element which has the filling opening at its end, which tubular element has an intermediate membrane filter for preventing the entry of harmful germs, the device also having anti-tamper security means in the portion disposed between the outlet from the container for the infusion liquid and the filter.

Abstract: A liquid-medicine injection port device includes: a liquid-medicine inlet which is formed at its upper end; a liquid-medicine outlet which is formed at its lower end which is connectable to a liquid-medicine container; a liquid passageway which connects the liquid-medicine inlet and the liquid-medicine outlet; a germ-removal filter which is provided in the liquid passageway; and a closure which closes the liquid passageway downstream from the germ-removal filter and opens it easily. Further, a liquid-medicine container is provided with this liquid-medicine injection port device. Or further, the liquid-medicine container has a two-chamber structure in which an injection chamber provided with the liquid-medicine injection port device which the germ-removal filter is attached to, and a storage chamber storing a liquid medicine are divided by a weak seal portion having such a strength that it is easily peeled.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, an activation assembly and a needle assembly for dispensing a dissolved medicament to a user. A dry compartment for storing a predetermined dry charge of dry medicament is located within the interior chamber. A wet compartment for storing a predetermined amount of liquid injection solution is also located within the interior chamber. A separation assembly separates the dry compartment from the wet compartment. The separation assembly prevents transfer of the liquid injection solution from the wet compartment to the dry compartment prior to activation of the automatic injection device. One or more medicament support assemblies located within the dry compartment prevent the passage of undissolved medicament from the dry compartment.

Abstract: The delivery system of the present invention is comprised of at least two chambers which store, individually, an activated blood component and an inactivated blood component. The first chamber comprises an activating agent and a filter which may be one in the same thus allowing the formed clot to be triturated thereby isolating the thrombin from the clot. The second chamber stores the inactivated blood component that when mixed with thrombin will produce a gel. The first or second chamber may further contain agents which are desired to be delivered to a specific site. The unique design of the delivery system allows for ease in operation of combining two agents at a specific time and place.

Abstract: An assembly of cannula and endoscope and dissection tip facilitate surgical procedures at remote surgical site in tissue of a patient. Relative rotation of the cannula about the endoscope from clamped rotational fixation of the cannula and endoscope is made possible by flexing a resilient clamping segment, and such relative rotation promotes convenient positioning of an eccentric tissue-dissecting tip about a vessel being harvested from within tissue of a patient. Color tinting of the tip or color-tinted illumination of tissue at a remote surgical site enhances contrasting visualization through the tip via the endoscope among the tissue types encountered at the surgical site within a patient. A tool bridge or lateral support mounts to a more rigid component such as an endoscope that extends from the proximal end of a cannula to support a more flexible surgical instrument also extending from the proximal end of the cannula.

Abstract: A first aspect of the invention relates to a method for aseptic preparation with an injection syringe. The syringe comprises a container for injection agent and an immovable connection nozzle connected to the container. The method entails charging the container with air. According to the invention air is forced to pass through an air filter arranged on the connection nozzle. This enables the syringe container to be charged with aseptic air in a simple and reliable fashion. Other aspects of the invention relate to devices for performing the method, viz. an injection syringe equipped with an air filter in the connection nozzle, a filter unit (2) connectable to an injection syringe's (1) connection nozzle (13) and a system comprising an injection syringe (1) and a separate filter unit (2). The invention devices convey advantages of the same kind as the invention method.

Abstract: A syringe comprising a one-way filter which permits flow of fluid into the syringe unfiltered but which filters the fluid when expelled from the syringe.

Abstract: The invention relates to a medical or dental-medical treatment instrument (1) having a media line, in particular for water or spray, extending from its rearward end to its forward end region, in which line an exchangeable filter element (21) is arranged. In order to reduce the flow resistance of the filter element (21), while providing a small cross-sectional size, the filter element (21) has the form of a sleeve and the direction of passage of the medium is directed transversely to the sleeve wall (21a).

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, a filter assembly, an activation assembly and a needle assembly. In accordance with the present invention, the interior chamber may include a dry compartment for storing a predetermined dry charge of dry medicament therein, and a wet compartment for storing a predetermined amount of liquid injection solution therein. The filter assembly enhances the laminar flow of fluid between the wet compartment to the dry compartment prior to the pressurization of the liquid injection solution within the wet compartment.

Abstract: A sampler cap includes a sampler connector, an analyzer connector and a liquid impermeable closure member, which may be a membrane or a filter. The sampler cap may be used to transfer a test sample to an analyzer without removing the sampler cap from the sampler.

Abstract: An injection device for injecting an injection solution prepared from a powdered medication in sterile water immediately before use which is administered by a syringe. A winged cannula has a hollow needle and a needle holder with wings. A female Luer Lock connector is joined to the winged cannula by a flexible connecting tube and has an insertion region for the connecting tube and a connection region for placing the syringe, filled with the injection solution, against a skin surface, and also has a continuous bore that is continuous from the insertion region to the connection region of the Luer Lock connector. A porous filter element permeable to the injection solution is provided in the continuous bore of the Luer Lock connector.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The injection device includes a housing assembly, a dry compartment located within the housing for storing a predetermined dry charge of dry medicament therein, and a wet compartment located within the housing for storing a predetermined amount of liquid injection solution therein. The injection device further includes an activation assembly that enables the pressurization of the liquid injection solution in the wet compartment. The activation assembly also enables the compression of the dry medicament within the dry compartment upon activation of the automatic injection device.

Abstract: Dosing device with at least two media chambers.

Abstract: An injection device includes a housing having a proximal end and a distal end, the housing defining a distal opening, and a first opening in a side of the housing and between the proximal and distal ends; a propellant disposed inside the housing and spaced from the distal end; and a movable member disposed inside the housing and between the distal end and the propellant, wherein the propellant is in fluid communication with the movable member and the first opening.

Abstract: An apparatus delivers an agent to a treatment region, the apparatus having an outer cannula or lumen that has an internal surface and an external surface, the external surface being substantially smooth to penetrate tissue whereas the distal end is tapered; an inner cannula, or lumen coaxial to the outer cannula, providing a common fluid path (that is the same fluid passes through both the inner cannula and outer cannula) at the distal end with the inner surface of the outer cannula; a source of fluid to be passed through the common fluid path, the source of fluid comprising at least a reservoir of nutrients and/or gases for maintaining cells contained in a lumen coaxial and internal to the inner cannula; a semipermeable membrane comprises the surface of the lumen, thus allowing controlled material transport across the lumen surface; a source of cells or other biologically active material mass flow connected to the proximal lumen so that the cells or other biologically active material can exit the distal port

Abstract: A method and an apparatus for preparing and culturing cells, particularly bone marrow stromal cells. The method includes the steps of placing an oxygenator and a scaffold in a container, such as a syringe, withdrawing bone marrow stromal cells with the syringe, evenly distributing the cells on the scaffold, connecting the syringe with a reservoir with a medium to enrich the syringe with the medium, and promoting the medium level movement in the syringe to culture bone marrow stromal cells.

Abstract: The invention provides systems containing a sterile container for aspiration, filtering, treating and reinjection into a subject of a bodily fluid in a sterile environment. The systems are particularly designed to facilitate transfection of cells within the sterile container by gene therapy molecules and reinjection of the transfected cells into the donor at controlled depth in precisely controlled volumes such as is useful for revascularization of ischemic cardiac tissue. For injection, a pressure actuator, preferably hand-held, applies force to liquids held within the sterile container in precisely controlled increments, thereby expressing liquids through a hollow needle or injection catheter in precisely controlled microvolumes. The invention systems include a hand-held injection device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.

Abstract: The method for manufacturing a blood filter adapted to be disposed in a blood vessel comprises, in the invention, the steps of a) providing a thin wall comprising a biocompatible material, b) producing in said thin wall a series of essentially parallel elongated sections, for defining the elongated legs, and having the elongated legs joined to each other, at a first end of the elongated sections, wherein step b) comprises the steps of producing adjacent essentially parallel strips comprising a first strip and a second strip separated by a slot, the strips extending essentially parallel the axis and each slot being interrupted at a distance from a second end of the elongated sections, so that the first and the second strips are connected to each other at said second end, by a continuous zone of said thin wall, and having the first strip of the elongated sections joined to each other, at said first end thereof.

Abstract: A hand-held syringe-like device has needle containing a trap with a barrel and plunger to draw air into and out of the needle through the trap. In a method of operating the device, particulate matter in air is retained in the trap and subsequently analytes from the trap are desorbed in an analytical instrument.

Abstract: A kit includes a point-of-care testing cartridge and a blunt cannula assembly. The blunt cannula assembly includes a blunt cannula that has a filter therein for filtering cellular components from whole blood and enabling plasma to be delivered by the blunt cannula to the testing cartridge.

Abstract: Multi-sectioned fluid delivery devices with sensor membranes for use in detection of target molecules in gas or liquid samples are provided.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, a filter assembly, an activation assembly and a needle assembly. In accordance with the present invention, the interior chamber may include a dry compartment for storing a predetermined dry charge of dry medicament therein, and a wet compartment for storing a predetermined amount of liquid injection solution therein. The filter assembly enhances the laminar flow of fluid between the wet compartment to the dry compartment prior to the pressurization of the liquid injection solution within the wet compartment.

Abstract: The delivery system of the present invention is comprised of at least two chambers which store, individually, an activated blood component and an inactivated blood component. The first chamber comprises an activating agent and a filter which may be one in the same thus allowing the formed clot to be triturated thereby isolating the thrombin from the clot. The second chamber stores the inactivated blood component that when mixed with thrombin will produce a gel. The first or second chamber may further contain agents which are desired to be delivered to a specific site. The unique design of the delivery system allows for ease in operation of combining two agents at a specific time and place.

Abstract: Filter device comprising a filter housing, a filter disposed in the filter housing, an inlet, and an opposed outlet spaced from the inlet, wherein the outlet comprises an extension from the housing, the extension extending longitudinally in the direction of fluid flow and comprising at least a first section having a minimum outer diameter and a second section downstream from the first section and having a terminal end having a maximum outer diameter, the maximum diameter of the second section terminal end being smaller than the minimum diameter of the first section.