Abstract: A gas conditioning trocar having a chamber for heating and hydrating an unconditioned insufflation gas prior to injecting a conditioned insufflation gas into a body cavity during a medical procedure and a port through which surgical instruments can pass into a body cavity without inhibiting the flow of insufflation gas during the medical procedure.

Abstract: An applicator is inserted into a living body and applies mixed solution to a region in the living body. The applicator includes a nozzle including an elongated nozzle main body to which gas and a plurality of kinds of liquids are supplied and a nozzle head at a distal end of the nozzle main body and configured to jet A mixed solution of the gas and the liquids supplied to the nozzle main body, and a sheath in which the nozzle main body is fitted for relative movement along a longitudinal axial direction of the nozzle main body. At least two crushed portions are provided contiguously to each other at a proximal end portion of the nozzle main body at the opposite side to the nozzle head such that deformation directions thereof with respect to an axial line of the nozzle main body are different from each other.

Abstract: An applicator is insertable into a living body to apply mixed solution to a region in the living body. The applicator includes a nozzle including an elongated nozzle main body to which gas and a plurality of kinds of liquids are supplied and a nozzle head at a distal end of the nozzle main body to jet mixed solution of the gas and the plurality of kinds of liquids supplied to the nozzle main body. The nozzle main body is positioned in a sheath for relative axial movement. A gap exists between the nozzle main body and the sheath to exhaust gas in the living body to the outside of the body when the pressure in the living body rises. The sheath has a plurality of side holes, each of which communicates with the gap.

Abstract: A method and apparatus for depositing a film on a biological substrate are provided. A plasma generation device includes a dielectric conduit and a high voltage electrode. The plasma generation device is placed in proximity to the biological substrate and a gas supply that includes a precursor material is directed through the dielectric conduit. An electric field generated by the potential difference between the high voltage electrode and the biological substrate ionizes at least a portion of the gas supply and causes plasma to emanate from the dielectric conduit and contact the biological substrate. The plasma induces a reaction of the precursor material to form a film that is deposited on the biological substrate.

Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

Abstract: Apparatus is provided, including a housing configured for insertion into a body of a subject; at least one oxygen reservoir disposed within the housing; and at least one layer of transplanted cells, disposed within the housing; and gaseous oxygen disposed within the at least one oxygen reservoir. Other embodiments are also described.

Abstract: The invention is to provide a gas mist pressure bath device which enables to cause efficiently absorb a gas mist into a skin or mucous membrane of a living-body, and attains to be compact and to lower cost. The device 10 is to cause oxygen, carbon dioxide, or a mixed gas (called as “gas” hereafter) of oxygen and carbon dioxide at a density of not less than a predetermined value to contact the skin or mucous membrane of the living-body, and the device comprises a gas mist generating means 11 for generating and supplying a mist (called as “gas mist” hereafter) prepared by pulverizing and dissolving the gas and liquid, and a substantially bag shaped living-body cover member 21 for covering the living-body's skin or mucous membrane and sealing inside, and the gas mist is supplied into the living-body cover member in order to heighten internal pressure therein so that the gas mist is caused to contact the living-body's skin or mucous membrane at a pressure more than the predetermined value.

Abstract: Embodiments of the present invention are directed to various designs and packaging methods for a gas delivery device and materials for supplying one or more predetermined gases to a target area as well as to application specific opthamological embodiments. With regard to the gas delivery device, the device may include a reservoir, a gas diffusion portion for communicating gas from the reservoir and one or more predetermined gases at concentrations greater than atmospheric contained within the reservoir, wherein the device does not generate gas and may be packaged prior to use with the one or more predetermined gases.

Abstract: A device containing sclerosant liquid for use in the treatment of blood vessels comprises an aerosol valve housing (29) mounted on a canister (26) having an expandable inner container (25) in which the sclerosant fluid is contained, wherein the expandable inner container is affixed to the outer opening of the canister or to the aerosol valve housing, whereby the introduction of pressurised gas through the aerosol valve causes the expandable inner container to inflate to accommodate the pressurised gas.

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 ?m. In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a therapeutic fluid, wherein said therapeutic fluid is a solution, a dispersion, or combination thereof and administering the produced therapeutic fluid intravenously to a patient; wherein the solution is supersaturated with the therapeutic gas, the therapeutic liquid, or combination thereof.

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 ?m. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

Abstract: A Personal Care Vaporizer Device for the Eye Area of the Face. A treatment chamber formed within the device will encircle the user's eyes and surrounding facial area when the device is positioned over the eye area of the face. A soft gel eyemask element provides maximum comfort for the wearer during treatment. The device introduces therapeutic mist or vapor into the treatment chamber. The mist/vapor is generated from an internal reservoir containing plain water or water mixed with other therapeutic additives. An onboard blower can control the flow rate of the mist/vapor into the treatment chamber. One or more onboard heating elements within the device provide direct heat to the treatment chamber wall(s), and/or to heat the mist/vapor prior to its being introduced into the treatment chamber. Onboard vibration generators apply soothing massaging motion to the user's face when activated.

Abstract: A system which can be used for injecting liquids as well as gases, and includes at least: one pipe for inputting gas into the system, with a device controlling the pressure of the input gas; a gas-injection device for adjusting a flow of gas to be supplied to a patient, at a predetermined pressure and with at least one flow sensor that determines the exact amount of gas supplied to the patient; a kit for administering gas to the patient; and at least one catheter or needle that can be connected to the administration kit and to the patient, with a bleed device arranged between the administration kit and the injection device.

Abstract: A cover for gas mist pressure bath includes a living-body cover member having an extension part extending from substantially center part of the living-body cover member, an adhesive part adhering the cover member to the skin and the mucous membrane of the living-body, a gas mist supply port for introducing the gas mist into the cover member for gas mist pressure bath, an outlet for exhausting air, the gas mist or the mixed gas sealed in the cover member for the gas mist pressure bath and controlling amounts of the gas, a fixing member fixing the cover member on the living-body, including a pair of belts extending from an edge of the adhesive part and a pair of belt stoppers adjusting the pair of belts, and a constricting ring pressurizing an inside of the living-body cover member to carry out pressurization.

Abstract: The present invention provides an apparatus for producing medical foam for wound care or hair stimulation. The apparatus includes a foam generation unit having a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

Abstract: Systems for insufflation and recirculation of insufflation fluid in a surgical procedure include a control unit having a fluid pump, a supply conduit, a return fluid conduit and a pressure-controlled valve. The pressure-controlled valve is in fluid communication with an insufflation gas supply, the supply conduit and the return conduit and is adapted and configured to respond to pressure control signals to adjust position and thereby system flow parameters, to reduce entrainment of air from the surrounding environment, and to increase the concentration of insufflation gas in an operative space, and/or to reduce an overpressure condition in the operative space.

Abstract: A plasma generating device that utilizes a cold plasma to contain and direct a stream of electrons with a hand held nozzle to enhance healing of wounds and skin surface abnormalities, and to kill pathogens on skin surfaces in humans and animals wounds, abnormalities and pathogens.

Abstract: A wound treatment apparatus includes a tray (10) having a region adapted to receive a patient's body part (e.g. a leg) for treatment, a spray head (22, 23) for applying a spray of a gas containing liquid onto the body part and a covered well (13) in the tray having inlets (18) for surplus liquid and gas from the spray. Outlets are provided in communication with the well for gas and liquid respectively for connection to a suction to draw surplus liquid and gas from the well, and a unitary coupling (20) provides a plurality of fluid connections including a liquid supply for the spray head and liquid and gas withdrawal from said well outlets.

Abstract: Provided is an apparatus that includes a scaffold with a gel or liquid composition deposed on at least a portion of a luminal surface, the gel or liquid composition adapted to include microbubbles. Also provided is a system that includes a source of reduced pressure, the above scaffold, a manifold adjacent the scaffold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above scaffold at the tissue site and disrupting a substantial portion of the microbubbles to induce fluid flow to the scaffold. Further provided is an apparatus that includes a scaffold that comprises a slowly degradable material and a quickly degradable material. Additionally provided is a system for coupling nerve tissue and a microchip assembly.

Abstract: An applicator for forming a film is disclosed. The applicator includes: a first extension tube coupled to a source of a modified cellulose solution; a shaft coupled to the first extension tube at a proximal end thereof, the shaft defining a first lumen in fluid communication with the first extension tube for transmission of the modified cellulose solution through the shaft; and an atomizer disposed at a distal end of the and configured to atomize the modified cellulose solution into a plurality of particles.

Abstract: An applicator and method for dispensing a stream of a particulate and a fluid from a cannula and a mixing tip. The mixing tip includes a housing having an inlet, an outlet, and a mixing channel extending therebetween. A fin is positioned within the housing and extends along at least a portion of the mixing channel. The fin spirals about the mixing channel from the inlet toward the outlet for mixing and distributing the particulate generally uniformly within the fluid. The stream is directed into the mixing channel of the mixing tip and spiraled along the fin within the mixing channel. The spiraling increases turbulence and mixes the stream into a mixed stream of particulate and fluid. The mixed stream is discharged from the mixing tip for being dispensed onto an anatomical site.

Abstract: A combination therapy pad that includes a first layer and a second layer operatively coupled to the first layer. A fiber-optic array is disposed between the first layer and the second layer. A third layer is operatively coupled to the first layer. The third layer includes a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source. The third layer provides at least one of vacuum therapy and therapeutic fluid treatment to a wound area.

Abstract: A stable transmucosal composition consisting essentially of naltrexone hydrochloride in water is provided. The composition is surprisingly stable at room temperature and can be used for simple, rapid and effective opioid overdose rescue.

Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

Abstract: A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.

Abstract: The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.

Abstract: Provided is a pressurized carbon dioxide bathing apparatus for bringing carbon dioxide into contact with skin of a living body by a predetermined pressure value or more using compressed air, and thereby enabling carbon dioxide to be absorbed efficiently from the skin, and the pressurized carbon dioxide bathing apparatus is comprised of a carbon dioxide supply means 1 for supplying a mixed gas of carbon dioxide and water vapor containing one or a plurality of chemical agents, a compressed air supply means 2, and a cover suit 3 of a two-layer structure having an enclosed layer 4 that is connected to the carbon dioxide supply means 1 via a connector 6 to confine the mixed gas supplied from the carbon dioxide supply means 1 so as to bring the mixed gas into direct contact with skin of the human body and an enclosed layer 5 that is connected to the compressed air supply means 2 via a connector 7 to confine compressed air supplied from the compressed air supply means 2, where the carbon dioxide is brought into cont

Abstract: The invention relates to a device for the plasma treatment of surfaces (47), in particular of skin, having a housing (3), a plasma source (5) allocated to the housing (3), and at least one spacer (21) that is provided on the housing (3) and/or the plasma source (5) in such a manner that a distance (d) between the plasma source (5) and a surface (47) to be treated can be maintained at least in some regions. The device is characterized in that the spacer (21) is designed to be adjustable in order to vary the distance (d) and that the distance (d) can be varied in such a manner that a preferred plasma chemistry can be selected at the location of the surface (47) to be treated.

Abstract: A method of applying a liquid or powder in a body cavity of a living body involves positioning the distal portion of an applicator in the living body, using an applicator that includes an outer tube and a nozzle having an elongated nozzle main body and a nozzle head at the distal end side of the nozzle main body. The method also includes relatively moving the outer tube and the nozzle so a curved section of the nozzle main body moves proximally relative to the outer tube and enters the outer tube to adjust the direction in which the nozzle is facing, conveying the liquid/powder through the nozzle main body and to the nozzle head, expelling the liquid or the powder from the nozzle head toward a surface in the body cavity, and discharging gas in the body cavity into a longitudinally extending gap and to outside the body cavity.

Abstract: A trocar for use in a minimally invasive surgical procedure includes an elongated body, nozzle means and means for delivering a pressurized flow of fluid to the nozzle means. The elongated body has a generally tubular configuration with coaxially arranged inner and outer walls and longitudinally opposed proximal and distal end portions, with the inner wall defining a lumen to accommodate passage of an instrument therethrough. The nozzle means is operatively associated with the inner wall of the body for directing pressurized fluid into the lumen to develop a pressure differential in an area within a region extending from a location adjacent a distal end portion of the lumen to a location adjacent a proximal end portion of the lumen, to form a fluid seal around an instrument passing therethrough.

Abstract: A fail-safe insufflation device having a thermal cutoff for interrupting power to an electrical heater to prevent overheating of insufflation gas wherein the thermal cutoff operates independent of a temperature control system to provide electrical shutdown of an electrical heater in response to a hostile temperature condition of the insufflation gas or a hostile temperature condition proximate the electrical heater.

Abstract: The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.

Abstract: A surgical console having bottles containing retinal tamponading gases and an automatic gas filling module disposed therein for filling an automatic gas filling consumable is disclosed. The automatic gas filling module includes a pair of gas shutoff valves and a regulator connected in series with a port for connection to the automatic gas filling consumable.

Abstract: Method and medical devices for generating and stabilizing micro or nano bubbles, and systems and methods for therapeutic applications using the bubbles, is provided. Two novel bubble generating means are provided: in-line capillary tubes and mix chambers flow focusing, and cross flow bubble generation with optimized bubble detachment means. A method and medical device to stabilize bubble sizes and improve bubble size homogeneity through rectified diffusion is disclosed. A method and system to facilitate acoustic activation of therapeutic agents using ultrasound energy is provided.

Abstract: In a gas supply system, a controller is electrically connected to a pressure regulator and an operation switch. The controller is operative to control the pressure regulator so that a predetermined gas is supplied to a first delivery member directing to a first body cavity with its pressure regulated to a first pressure suitable for the first body cavity. The controller is operative to control the pressure regulator depending on an instruction sent from the operation switch upon operation of the operator so that the predetermined gas is supplied to a second delivery member directing to a second body cavity with its pressure regulated to a second pressure suitable for the second body cavity.

Abstract: The invention relates to a device (1) for the directed application of a substance (X) in a hollow space (200), such as a hollow organ, of a body cavity, in particular a therapeutic pneumoperitoneum, comprising: a trocar system with a trocar sleeve (45), said trocar system (40) having a gas connection (43) to which an insufflation gas-supply line (81) can be connected, and a nozzle system (20), which in its interior forms a lumen (26), with a proximal end (21) and a distal end (22), wherein the nozzle system (20) has a needle nozzle (30) fixed at the distal end (22) with the lumen (26) and is guided by the trocar sleeve (45).

Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.

Abstract: A charged hydration device and a method of filling the hydration device so the charged hydration that can be mounted to a medical apparatus that provides insufflation fluid to a body cavity either immediately prior to the medical procedure or during a medical procedure with the charged hydration device including an inlet and outlet for an inline connection with the medical apparatus so that an insufflation gas delivered through the charged hydration device is hydrated to prevent tissue damage to a person receiving the insufflation gas.

Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

Abstract: The invention relates to a ready-to-use syringe containing a mixture of air and a heavy gas in a predetermined mixing ratio. The syringe is for use as a gas tamponade system for medical applications. The tamponade is used to fill a natural cavity resulting e.g. from the shrinkage of a vitreous humour due to ageing, or an artificial cavity resulting e.g. from a vitrectomy.

Abstract: A gas mist pressure bathing system, which integrates a gas introduction part for increasing the supply pressure of a gas mist with a gas mist generator and enables the structure to be simplified and costs to be reduced, is provided. The gas mist pressure bathing system is provided with a gas supply means (10), a gas mist generating means (30), and a living body cover member (50).

Abstract: Oxygen diffusive wound dressings and methods of manufacturing and use are described herein. The wound dressing may generally provide a ready supply of oxygen to a wound being treated via one or more oxygen conduits which are designed to pass oxygen from ambient air or other oxygen reservoirs into proximity to the wound, and may also provide for exudate removal through transecting channels in fluid communication with both the wound surface and a hydrophilic absorbent material.

Abstract: Provided are a gas mist pressure bathing method and a gas mist pressure bathing system that improve the efficiency of absorbing a gas mist from the skin and mucous membranes of a living body. The gas mist pressure bathing method is provided with a first step, a second step and a third step. The first step involves supplying a gas mist for a predetermined time to at least a first cover 51 of a living body cover member 50 having said first cover 51 and a second cover 55 positioned outside of the first cover 51, the inside of said second cover 55 being substantially sealed; covering the skin and mucous membranes of the living body; and forming a space wherein the gas mist supplied by a gas mist generating means 30 is sealed. The second step involves discharging the gas mist from the first cover 51 and/or the second cover 55.

Abstract: The present invention provides methods of treatment by delivering nitric oxide at a pressure greater than 1 atmosphere (atm) to a subject in need thereof. Thus, the present invention provides an improved method of treating the skin surface of a subject, and below the skin surface of a subject.

Abstract: Method and medical devices for generating and stabilizing micro- or nano-bubbles, and systems and methods for therapeutic applications using the bubbles, are provided. The micro-bubbles may be used to enhance therapeutic benefits such as ultrasound-guided precision drug delivery and real-time verification, acoustic activation of large tumor masses, enhanced acoustic activation through longer retention of therapeutic agents at the point of interest, enhancement of high intensity focused ultrasound treatments, light activation of photodynamic drugs at a depth within a patient using extracorporeal light sources, probes, or sonoluminescence, and initiation of time reversal acoustics focused ultrasound to permit highly localized treatment.

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 ?m. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

Abstract: A system for selectively pressurizing ventricles, atria, and the aorta of a subject is disclosed. The surgical pressunzation system has a gas container, a fluid container, and a surgical pressurization device. The gas container and the fluid container are in fluid communication with the surgical pressurization device. The gas container contains a pressurized gas, and the fluid container contains an irrigation fluid. The surgical pressurization device has a housing and a delivery conduit in fluid communication with the housing. The delivery conduit selectively delivers both the pressurized gas and the irrigation fluid into the ventricles, atria, and the aorta of the subject. A controller is used to control the flow of the pressurized gas and the irrigation fluid to the delivery conduit.

Abstract: An internal anatomic target that is infected by pathogenic microorganisms is treated using an applicator configured for delivering a therapeutic solution thereto and an UV light-emitting device transmits UV light thereon.

Abstract: Provided are a gas mist pressure bathing method and a gas mist pressure bathing system that improve the efficiency of absorbing a gas mist from the skin and mucous membranes of a living body. The gas mist pressure bathing method is provided with a first step, a second step and a third step. The first step involves supplying a gas mist and gas for a predetermined time to at least a first cover 51 of a living body cover member 50 having said first cover 51 and a second cover 55 positioned outside of the first cover 51, the inside of said second cover 55 being substantially sealed; covering the skin and mucous membranes of the living body; and forming a space wherein the gas mist and gas supplied by a gas mist generating means 30 are sealed. The second step involves discharging the gas mist and gas from the first cover 51 and/or the second cover 55.

Abstract: The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.