Abstract: A system and method for creating a medicated atmosphere in an organ, or body cavity is disclosed. The system includes a flexible aerosolization catheter that can be manipulated during use, a device for the introduction of the aerosolization catheter, a medication delivery apparatus configured to control delivery of a medication to the catheter, a gas delivery apparatus in communication with the catheter, a gas pressure relief apparatus configured to relieve pressure in the organ or body cavity, and a central controller The method includes providing insufflation gas and an aerosol of medication to an organ or body cavity while controlling overall pressure in the organ or cavity. The method may also include re-entering a patient through at least one port to apply gas and an aerosolized medicament, in either a post-operative procedure or in a chemotherapy context.

Abstract: Certain embodiments relate to a sprayer or other medical apparatus for applying a biocompatible coating in situ. Such an apparatus may have a first conduit connected to a first exit opening and a second conduit connected to a second exit opening to deliver a first composition through the first conduit and a second composition through the second conduit to mix the first composition and the second composition outside both the first conduit and the second conduit. The first composition may be, e.g., a precursor to a material formed after the mixing of the first composition and the second composition. The first exit opening and the second exit opening may be approximately adjacent to each other and define an angle that is less than about 140 degrees.

Abstract: The present invention is to provide a gas mist pressure bathing system which controls amounts and pressure of gas and liquid for causing a gas mist to be absorbed into the skin and mucous membrane of the living organism.

Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

Abstract: The subject multimodal surgical gas delivery system configured to couple to one or more surgical devices providing access into a patient body cavity includes a computer-controlled control unit configured and adapted to provide at least one of the following modes of operation. A first mode of operation for providing a pressurized insufflation fluid from an insufflation gas source into a surgical device for providing and maintaining sealable access to the body cavity in a surgical device. A second mode of operation for performing smoke evacuation in a filter element from insufflation fluid caused to recycle through the multimodal system from the body cavity via a surgical device. A third mode of operation for providing insufflation fluid from the insufflation gas source into the body cavity for creating and maintaining insufflation of the body cavity.

Abstract: Provided is a chitosan spreading system using low temperature atmospheric pressure plasma.

Abstract: The present invention is directed to an intermittent aerosol dispensing device, for application of a product to skin of a human being, where the aerosol dispensing device includes an intermittent injection mechanism located downstream of an aerosol valve of an aerosol dispenser and responsive to a pushbutton of the aerosol dispensing device, and the aerosol dispensing device further includes a pressure chamber. A ratio of an injection time to a stop time is set, in said intermittent injection mechanism, to 0.1 to 5.0, so that when said aerosol valve is opened a cycle of injection and stop is performed 1 to 25 times per second in order to obtain a cooling and/or massage effect on the skin.

Abstract: Embodiments of the present invention relate to systems, devices, and methods for delivering distending media to an organ of a patient with a dispensing device for acquiring an image of the organ while distended. In one embodiment, an insufflating system comprises a controller for detecting a pressure level of the distending media within an organ of a patient, wherein the controller is configured to signal an operator to acquire an image of the organ when the pressure level is within a predetermined pressure range for a predetermined period of time. Further, the insufflating system comprises a valve assembly in communication with the controller and in fluid communication between the source of distending media and the organ of the patient, wherein the valve assembly is configured to adjust a flow rate of the distending media delivered to the organ of the patient, and an administration set configured to direct the distending media from the valve assembly to the organ of the patient.

Abstract: A method for repairing pulmonary air leaks in a lung residing in a chest cavity and having an intake air stream and an outer surface is disclosed. An exemplary method comprises: introducing a first component of a biphasic sealant component as a liquid into the intake air stream of the damaged lung; ensuring that there is a pressure differential between the intake air stream and the outer surface of the lung; and introducing a second component of a biphasic sealant component into the chest cavity. The first sealant component collects at the air leak site and forms a sealant in combination with the second sealant component.

Abstract: A valve assembly comprising a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed.

Abstract: An indexed drug delivery device (70) comprising a valve assembly (13) comprising a housing (26) and a valve, the valve disposed within the housing, one or more keys (34,38) integral to the housing, the keys complementary to corresponding openings on a collar (12), a pressurized canister (28) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis.

Abstract: Improved therapeutic sclerosing microfoams and methods and devices for making them are provided that have advantage in producing a consistent profile injectable foam with minimal input by the physician yet using high volume percentages of blood dispersible gases, thus avoiding use of potentially hazardous amounts of nitrogen.

Abstract: Apparatus, e.g. a syringe, for dispensing foam includes means for ensuring that only foam of adequate quality is dispensed. In use, the syringe may be filled from a pressurised canister which generates foam e.g. for therapeutic use in treating varicose veins. An initial quantity of foam dispensed from the canister may be of inadequate quality in which case it should not be used: the syringe includes means to ensure that this initial quantity of foam is diverted to a waste port or to an internal waste chamber e.g. located in the syringe plunger. Foam dispensed after the initial quantity of poor quality foam is stored in the main barrel of the syringe ready for administration to a patient in need of treatment.

Abstract: A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface.

Abstract: A method and apparatus for delivering therapeutic or diagnostic agents as a low pressure high velocity spray into tissue. According to the particular desired spray characteristics, the spray may be generated via the combined use of pressure atomization and electrostatic spray charging, or via the combined use of pressure atomization and electrostatic atomization. Particle velocity, spray flow-rate, and spray dispersion are further controlled via electrostatic means.

Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

Abstract: A method of treating a wound using condensation warming is disclosed. A wound dressing is applied over the wound in which the wound dressing has an inlet and an outlet and furthermore forms a substantially airtight cover over the wound. A vapor is supplied to the wound dressing via the inlet. The wound is warmed by condensing the vapor into a condensate on a surface of the wound, thereby releasing a latent heat of vaporization. The condensate is removed from the wound dressing via the outlet.

Abstract: The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.

Abstract: A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure.

Abstract: An insufflation gas warmer and humidifier apparatus and methods are provided. Insufflation gas is received from a bulky insufflation tubing. Insufflation gas received travels through, in one aspect, a channel or winding flow path, in a passage. The configuration of the passage ensures that the insufflation gas, which travels through the passage, receives sufficient heat and moisture. A humidifying reservoir humidifies the insufflation gas as the insufflation gas is passed to the passage. In one aspect, an oxygenator introduces slight amounts of oxygen into the insufflation gas. A warmer connected to the passage warms the gas in the passage. The warmer, in one aspect, contains a reactive agent that when exposed to air produces heat that is transferred to the passage to warm the insufflation gas within the passage.

Abstract: In a hyperbaric dressing a first fluid, such as oxygen, is deliverable between a fluid-impermeable layer impermeable to the first fluid and a fluid-permeable layer permeable to the first fluid. Edges of the fluid-impermeable layer and the fluid-permeable layer are sealed together and edges of the dressing are securable to a patient's skin surrounding a wound. Thus, when the first fluid is delivered, it can permeate through the fluid-permeable layer into a headspace between the dressing and the wound. A perforation is defined through the fluid-permeable layer and the fluid-impermeable layer for the passage of a second fluid, such as wound exudate. The perforation is open when a pressure in the headspace between the wound and the dressing is above a pre determined pressure and is closed when the pressure is below the predetermined pressure.

Abstract: Methods, systems and devices are described for temporarily or permanently evacuating stagnating air from a diseased lung area, typically for the purpose of treating COPD. Evacuation is accomplished by displacing the stagnant CO2-rich air with a readily diffusible gas using a trans-luminal indwelling catheter specially configured to remain anchored in the targeted area for long term treatment without supervision. Elevated positive gas pressure in the targeted area is then regulated via the catheter and a control unit to force under positive pressure effusion of the diffusible gas out of the area into neighboring areas while inhibiting infusion of other gases thus effecting a gradual gas volume decrease and deflation of the targeted area, thereby reducing volume of ineffective areas, increasing tidal volume of better areas, and improving lung mechanics.

Abstract: An apparatus for administering a therapeutic is provided. In various embodiments, the apparatus includes a syringe having a barrel and a plunger and having a material treatment module associated with a needle. The material treatment module may be an ozone generator that is initiated such that material containing ozone accumulates within the needle. The material can then be delivered from the barrel into a target site via the needle, thereby delivering therapeutic effects to that target site.

Abstract: A method for administering a therapeutic is provided. In various embodiments, the method includes providing a handheld dispensing apparatus comprising a housing defining a chamber, a material treatment module in material communication with the chamber, an outlet in material communication with the chamber, and a needle in material communication with the outlet for releasing the material from the housing. The method includes collecting a precursor material in the chamber, activating the material treatment module, treating the precursor material collected in the chamber with the material treatment module to create a treated material, positioning the needle in a body, and dispensing the treated material out of the apparatus into the body.

Abstract: The present invention is to provide a gas mist pressure bathing system enabling to cause a gas mist to be absorbed into the skin and the mucous membrane of the living organism under an optimum condition of controlling the amounts of gas and liquid.

Abstract: Gases are smoothly and automatically switched when using two gas supply sources, that is, an air pump and a carbon dioxide gas cylinder. By using a gas supply flow rate adjusting unit, a carbon dioxide gas is supplied to an endoscope, and a gas using a carbon dioxide gas and water are delivered. When the remaining amount of the carbon dioxide gas of the cylinder is detected and the detected pressure of the carbon dioxide gas becomes less than a predetermined value, the air pump is rotated to supply pressurized air. The rotation number of the air pump is controlled, and the same amount of pressurized air is supplied as that of the supplied carbon dioxide gas. The switching to the pressurized air is automatically performed. The supply amounts before and after the switching become equal to each other, and a surgical operator does not feel any discomfort.

Abstract: Apparatus and methods deliver vasoconstrictive agents simultaneously with capnic gases. The capnic gases can enhance the effectiveness of the vasoconstrictive agent, lower the dosage of drug or concentration of agent necessary to achieve a therapeutic result, or both. Exemplary capnic gases include carbon dioxide, nitric oxide, nitrous oxide, and dilute acid gases.

Abstract: An apparatus for producing medical foam for wound care or hair stimulation has a foam generation unit including a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

Abstract: The invention is to provide a gas mist pressure bath device, which causes to contact carbon dioxide, oxygen or a mixed gas of carbon dioxide and oxygen to the skin or mucous membrane of the head of a living body at pressure higher than a predetermined value for efficiently enabling skin-pass absorption.

Abstract: In accordance with one embodiment of the present disclosure, a surgical method may include making a first incision in a patient. The surgical method may also include receiving a gas from a source and humidifying and warming the gas received from the source. The surgical method may further include delivering the humidified and warmed gas into the first incision. The surgical method may further include separating one or more blood vessel branches from a blood vessel using at least one surgical instrument inserted through a second incision in the patient. The surgical method may further include removing a blood vessel segment from the patient through a third incision in the patient, wherein the blood vessel segment was in contact with the humidified and warmed gas delivered into the first incision prior to the removal.

Abstract: The present invention is to provide a gas mist mask device which is compact and economical, and enables to take a mist bath for the face or the eyes by using the physiological actions of oxygen or carbon dioxide.

Abstract: A gas apparatus for use in a medical procedure may include a housing, a heater, a port, and a dispensing device. The housing defines a chamber having a gas inlet and a gas outlet. The heater warms a gas flowing through the chamber. The port is positioned in fluid communication with the chamber. The dispensing device is inserted within the port for delivering water in aerosol form to warmed gas as it exits the gas outlet.

Abstract: A system and method of injecting a gas enriched and/or emulsified first liquid into a second liquid is disclosed. The injection can cause generation of a high density of bubbles having a mean diameter of a selected size. The mean diameter of the bubbles can be selected and varied based on the characteristics of the injection system.

Abstract: An apparatus for conditioning gas for use in a medical procedure, the gas being received into the apparatus from a gas source. The apparatus comprises a housing defining a chamber having an entry port and an exit port. The housing contains at least a humidification means comprising a container for liquid, such as at least one liquid retaining layer that is disposed within the chamber in the path of travel of the gas for humidifying the gas as it passes through the chamber. A humidity sensor may be disposed within the chamber that senses the humidity of the gas exiting the chamber. A monitoring circuit is connected to the humidity sensor that detects when the chamber requires a recharge of liquid based on the humidity of the gas in the chamber, and generates a recharge signal indicative thereof a charging port on the housing provides access into the chamber to recharge the chamber with water. Alternatively, a backup container of liquid is provided to continuously supply liquid to the humidification means.

Abstract: Apparatus for gas delivery (10), particularly at low pressure and volume. The apparatus has a gas reservoir, a delivery line between the gas reservoir (14) and a gas outlet (68) and a first supply line between a first inlet connect able to a first gas supply and the gas reservoir. A pressure control line is provided with an inlet connect able to a second gas supply. The pressure control line is coupled to the gas reservoir to thereby control the pressure in the gas reservoir.

Abstract: In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 ?m. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof, a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.

Abstract: The present invention is to provide a gas mist pressure bathing cover which is simple in a structure and easy in pressurization.

Abstract: The present invention provides methods of treating bacterial, viral, protozoan, parasitic, arthropod and fungal infections by applying gaseous nitric oxide to a patient having an infection. The present invention further provides improved methods of treating bacterial, viral, protozoan, parasitic and fungal infections by applying gaseous nitric oxide, in combination with oxygen, to a patient having an infection.

Abstract: A wound treatment apparatus includes a tray (10) having a region adapted to receive a patient's body part (e.g. a leg) for treatment, a spray head (22, 23) for applying a spray of a gas containing liquid onto the body part and a covered well (13) in the tray having inlets (18) for surplus liquid and gas from the spray. Outlets are provided in communication with the well for gas and liquid respectively for connection to a suction to draw surplus liquid and gas from the well, and a unitary coupling (20) provides a plurality of fluid connections including a liquid supply for the spray head and liquid and gas withdrawal from said well outlets.

Abstract: An apparatus for use in insufflation of a body cavity 5, such as through a trocar 6 is described. One such application is laparoscopic surgery. The device is also suitable for use in any situation involving insufflation of a body cavity such as in arthroscopies, pleural cavity insufflation (for example during thoracoscopy), retroperitoneal insufflations (for example retroperitoneoscopy), during hernia repair, during mediastinoscopy and any other such procedure involving insufflation. The apparatus comprises a reservoir 1 for storing an liquid solution, an aerosol generator 2 for aerosolising the solution, and a controller 3 for controlling operation of the aerosol generator 2. Aerosolised liquid solution (which main contain a pharmaceutical) is entrained with insufflation gas using a T-piece connector or housing 30 having an insufflation gas inlet 31 and an outlet 32.

Abstract: A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

Abstract: A surgical blower for providing a directed stream to clear a surgical site, that can be used in multiple different use modes. In one use mode, the surgical blower is handheld by a user during operation. In another mode, a distal end portion of the blower is fixed to a foot of a stabilizer instrument and the handle of the blower is handheld. In another mode, a distal end portion of the blower is fixed to a foot of a stabilizer instrument and the handle of the blower is fixed to a stationary object such as a sternal retractor. In another mode, the distal end of the blower is free and the handle of the blower is fixed to a stationary object. An apparatus including a blower and a stabilizer is provided. Methods of using the blower as well as the apparatus are also provided.

Abstract: The invention to provide a gas mist pressure bath system which is possible to control the amounts, pressures and others of gas and liquid, and cause the gas mist to be absorbed through the skin and mucous membrane of a human living organism under an optimum condition. This system is for preparing a mist (gas mist) by pulverizing and dissolving a gas (carbon dioxide or oxygen, otherwise a mixed gas) and a liquid at a density of not less than a predetermined value, and contacting the mist to the skin and mucous membrane of a living organism.

Abstract: Apparatus used in insufflation comprises an insufflator 12 for generating an insufflation gas such as carbon dioxide and an aerosol generator 2 for aerosolising a fluid and entraining the aerosol with the insufflation gas. The aerosol generator 2 comprises a vibratable member 40 having a plurality of apertures extending between a first surface and a second surface. The fluid may comprise a therapeutic or prophylactic agent. A controller 3 is used to control the operation of the aerosol generator 2. The controller 3 controls operation of the aerosol generator 2 responsive to the flow of insufflation gas such as detected by a flow sensor 11.

Abstract: A gas supply apparatus measures a first pressure inside a first body cavity of a patient and a second pressure inside a second body cavity of the patient. The gas supply apparatus regulates a pressure of a predetermined gas based on the measured first and second pressures inside the first and second body cavities.

Abstract: The invention discloses methods and devices for promotion of skin healing, skin conditioning and skin rejuvenation for skin and tissue repair. More specifically, the invention is directed toward the manufacture of a storable therapeutic pad containing a therapeutic solution within a matrix. The therapeutic solution is produced by mixing oxygen with a fluid such as normal saline using an ultrasound station. Alternatively, the matrix may be composed of gels, solids and fibrous materials. The ultrasound station can be used to form micro-bubbles containing oxygen which allow storage of relatively high quantities of oxygen in a storage container containing the therapeutic pad. Micro-bubbles may be attached to stands or contained within a closed-cell foam. At the appropriate time, the storage container is opened and the therapeutic pad is attached to the wound site. The therapeutic pad is held between an impermeable layer and the wound site with an adhesive layer.

Abstract: A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto.

Abstract: A device and a method for preparing foam are provided. The device includes a first housing having a first chamber therein and a first movable member positioned at least partially within the first housing. The device also includes a second housing having a second chamber therein, the second chamber being selectively and operably connectable to the first chamber. The second housing further includes a biasing member and a second movable member therein, the biasing member biasing the movable member toward a first end portion of the second housing. The device includes a valve operably connected to the first chamber and the second chamber and movably positionable to selectively control the connection between the first chamber and the second chamber and a handle operably connected to the first movable member and movable to bias the first movable member toward a first end portion of the first housing.

Abstract: An electrosurgical apparatus for coagulating tissue used in combination with an endoscope which includes an elongated flexible tube having a plurality of side-ports located therethrough. The tube extends through a working channel of the endoscope and an ionizable gas is supplied to the tube at or near the proximal end of the tube. A diffusing member directs the ionizable gas from the proximal end of the tube through each of the side-ports towards the tissue. An electrode is used for ionizing the gas prior to the gas exiting the side-ports.

Abstract: Apparatus formed by a shell that may be placed around a part of the body, wherein said shell comprises: an inlet that may be connected to a gas source and an outlet to evacuate the gases present inside the shell; at least two complementary portions defining between them a cavity with a cross section that is larger than that of the part of the body to be treated, characterised in that the walls of the two complementary portions have an average heat conduction that is lower than 65 mW/m·K measured according to EN-12667.