Abstract: An ultrasound apparatus capable of mixing and/or atomizing fluids is disclosed. The apparatus includes a horn having an internal chamber, containing at least one free member, through which fluids to be atomized and/or mixed flow. Connected to the horn's proximal end, a transducer powered by a generator induces ultrasonic vibrations within the horn. Traveling down the horn from the transducer, the ultrasonic vibrations induce the release of ultrasonic energy into the fluids to be atomized and/or mixed as they travel through the internal chamber. As the ultrasonic vibrations travel through the chamber, the fluids within the chamber are agitated and/or begin to cavitate, while the free member moves about the chamber, thereby mixing the fluids. Upon reaching the front wall of the chamber, the ultrasonic vibrations echo off the front wall and pass through the fluids within the chamber a second time, further mixing the fluids.

Abstract: A sealable cabinet that permits a human or animal to experience a dry bath for carbon dioxide or other gases, with said cabinet fitted with gas, water, and power connections, and a controller to optimize the temperature, gas concentrations, and water vapor content of the interior, plus a switchable means for selecting between a sauna environment and said carbon dioxide bath, with a business method that enables a provider of services involving such equipment to achieve a profitable interface with patients and customers.

Abstract: A device and method for delivering a multi-phase mixture of a composition dispersed in a gas, the device comprising an outer needle having an inlet opening configured to receive a supply of the composition, and an inner needle disposed within the outer needle, the inner needle comprising an inlet opening configured to receive a pressurized supply of the gas, where a tip of the inner needle is offset inward from a tip of the outer needle along a longitudinal axis by an offset distance.

Abstract: A method and apparatus for treating gas for delivery into a body cavity, body space or body surface of an animal. The apparatus comprises a housing defining a chamber having an entry port and an exit port. One or more agents are released into the gas stream that flows through the chamber so that the gas stream carries the agent to the animal. Also shown, for use with, or without, the chamber, is an agent chamber adapted to be coupled to at least one structure defining at least one fluid flow path extending at least a portion of the distance between an insufflation device and the body cavity, body space or body surface.

Abstract: The present invention provides a carbon dioxide external administration device according to which assured cosmetic and medical effects can be readily obtained. This administration device comprises a sealing enclosure member capable of sealing a body surface from the outside air, a supply means for supplying carbon dioxide into the inside of the sealing enclosure member, and an absorption aid that assists transdermal or transmucosal absorption of the carbon dioxide inside the sealing enclosure member. The administration device may further have a carbon dioxide amount indicator that expands upon carbon dioxide being supplied into the sealing enclosure member, and contracts by the decrease of carbon dioxide.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: The present invention relates to a device for abrading or cleansing tissue. The device includes a gas inlet port connected to a pressurized gas source, and a liquid inlet port connected to a pressurized liquid source. There is, additionally, a mist jet delivery nozzle arrangement, which includes one or more gas discharge nozzles arranged to receive a flow of pressurized gas from the gas inlet port and configured to accelerate the flow of gas so as to discharge it at an elevated velocity. Further, there are one or more liquid discharge nozzles arranged to receive a flow of liquid from the liquid inlet port and operative to discharge the flow of liquid into the elevated velocity flow of gas, thereby to similarly accelerate the velocity of the discharged liquid as a mist of accelerated droplets.

Abstract: The present invention is to provide a cover for a gas mist pressure bath, which can cause to efficiently absorb a gas mist into a skin and mucous membrane of a living-body, exhaust air, gas or gas mist within a cover for a gas mist pressure bath, and easily control pressure inside of the cover.

Abstract: A multiple layer microfluidic system and multiple layer microbubble are disclosed. The microfluidic system for producing multiple layer microbubbles includes a first inlet which receives a gas and directs the gas into a central stream, a second inlet which receives an oil and flow focuses the oil around the gas, a third inlet which receives a polymer and lipid solution and flow focuses the polymer and lipid solution around the oil and a fourth inlet which receives a surfactant solution and flow focuses the surfactant solution around the polymer and lipid solution. The multiple layer microbubble includes a gas core, a polymer and lipid shell surrounding the gas core and a surfactant layer surrounding shell.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living-body under an optimum condition, in which a mist is prepared by pulverizing and dissolving carbon dioxide or oxygen or a mixed gas of carbon dioxide and oxygen and a liquid at a density of not less than a predetermined value, and the thus prepared gas mist is directly contacted to the skin and mucous membrane of the living-body, the gas mist pressure bath system comprises a gas supply means 11, a liquid supply means 21, a gas mist supply means 31 for generating and supplying the gas mist prepared by blowing off gas supplied from the gas supply means into the liquid supplied from the liquid supply means 21, and the living body cover member 41 of covering the skin and mucous membrane of the living-body and forming a space of sealing the gas mist inside thereof, and the gas mist pressur

Abstract: An insufflation gas warmer and humidifier apparatus and methods are provided. Insufflation gas is received from a bulky insufflation tubing. Insufflation gas received travels through, in one aspect, a channel or winding flow path, in a passage. The configuration of the passage ensures that the insufflation gas, which travels through the passage, receives sufficient heat and moisture. A humidifying reservoir humidifies the insufflation gas as the insufflation gas is passed to the passage. In one aspect, an oxygenator introduces slight amounts of oxygen into the insufflation gas. A warmer connected to the passage warms the gas in the passage. The warmer, in one aspect, contains a reactive agent that when exposed to air produces heat that is transferred to the passage to warm the insufflation gas within the passage.

Abstract: The invention is to provide a cover for a gas mist pressure bath, which can cause to efficiently absorb a gas mist into a skin and mucous membrane of a living-body, exhaust air, gas or gas mist within a cover for a gas mist pressure bath, and easily control pressure inside of the cover.

Abstract: A water jet surgical instrument including a supply line for supplying a cutting fluid and a discharge nozzle for forming and discharging a fluid jet, wherein the fluid jet has a predetermined spread angle and/or a predetermined emergence energy. A jet shaping device is arranged relative to the discharge nozzle such that the fluid jet is able to be adjusted by the jet shaping device with regard to the spread angle and/or emergence energy thereof.

Abstract: Various embodiments described herein promote accelerated healing of a wound. For example, in some embodiments, a gas emitter, such as an oxygen emitter, and a therapeutic agent, such as a zeolite, are positioned proximal to a wound. In some embodiments, the therapeutic agent is dispersed or contained in a substrate or pouch removably attached to the gas emitter. The therapeutic agent can be a topical agent configured to make contact with the wound during therapy.

Abstract: An applicator insertable into a living body includes a nozzle having an elongated nozzle main body and a nozzle head on a front end side of the nozzle main body and through which liquid together with gas is expelled, with the nozzle main body including a flexible curved section. The applicator also includes an outer tube in which is positioned a portion of the nozzle main body so as to be movable along a longitudinal direction. The angle or degree of curvature of the curved section is changed by inserting the curved section into the outer tube to thereby adjust the direction of the nozzle head relative to the axis of the nozzle main body. In addition, a longitudinally extending gap exists between the outer tube and the nozzle. The gap functions as a discharge path for discharging the gas within the body cavity.

Abstract: The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery systems overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The delivery systems administer precise doses of a substance to a precise location from unit dosage forms that may be single-dose or multiple-dose unit dosage forms, which may be externally or internally pierced.

Abstract: Methods are provided for treatment of acute ischemic brain stroke based on the delivery of a measured amount of ozone to a sample of a mammalian patient's blood, blood fractionate or other biological fluid through the use of an ozone delivery system. The ozone-treated fluid, having absorbed a quantifiable absorbed-dose of ozone, is subsequently reinfused into the same patient and the autologous blood sample provides therapeutic effects to the patient, such as reduction in edema associated with the ischemic penumbra, improvement in impaired blood flow to the area surrounding the infarct, relaxation of the vascular endothelium and reduction of inflammation.

Abstract: A sprayer includes a nozzle through which gas is to be ejected with positiveness and uniformity. The sprayer is provided with a nozzle having inner tubes through the interior of which liquid is to pass and an outer tube receiving the inner tubes therein and allowing gas to pass through a space defined with the inserted inner tubes. The inner tubes have respective liquid orifices through which liquids are to be ejected. The outer tube is arranged therein with the liquid orifices and a gas orifice for ejecting gas. When the nozzle is viewed from front, the outer peripheries of the liquid orifices each assume a circular form while the inner peripheries of the gas orifices are differently shaped to provide plural point contact between the outer periphery of the liquid orifice and the inner periphery of the gas orifice.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living-body under an optimum condition, in which a mist is prepared by pulverizing and dissolving carbon dioxide or oxygen or a mixed gas of carbon dioxide and oxygen and a liquid at a density of not less than a predetermined value, and the thus prepared gas mist is directly contacted to the skin and mucous membrane of the living-body, the gas mist pressure bath system comprises a gas supply means 11, a liquid supply means 21, a gas mist supply means 31 for generating and supplying the gas mist prepared by the liquid nozzle 32 of pulverizing and dissolving the gas supplied from the gas supply means 11 as well as the liquid supplied from the liquid supply means 21, and the living body cover member 41 of covering the skin and mucous membrane of the living-body and forming a space of sealing t

Abstract: The invention is to provide a gas mist pressure bath device which enables to cause efficiently absorb a gas mist into a skin or mucous membrane of a living-body, and attains to be compact and to lower cost. The device 10 is to cause oxygen, carbon dioxide, or a mixed gas (called as “gas” hereafter) of oxygen and carbon dioxide at a density of not less than a predetermined value to contact the skin or mucous membrane of the living-body, and the device comprises a gas mist generating means 11 for generating and supplying a mist (called as “gas mist” hereafter) prepared by pulverizing and dissolving the gas and liquid, and a substantially bag shaped living-body cover member 21 for covering the living-body's skin or mucous membrane and sealing inside, and the gas mist is supplied into the living-body cover member in order to heighten internal pressure therein so that the gas mist is caused to contact the living-body's skin or mucous membrane at a pressure more than the predetermined value.

Abstract: A system and method for creating a medicated atmosphere in an organ, or body cavity is disclosed. The system includes a flexible aerosolization catheter that can be manipulated during use, a device for the introduction of the aerosolization catheter, a medication delivery apparatus configured to control delivery of a medication to the catheter, a gas delivery apparatus in communication with the catheter, a gas pressure relief apparatus configured to relieve pressure in the organ or body cavity, and a central controller in communication with the medication delivery apparatus, gas delivery apparatus, and gas pressure relief apparatus control of the various means. The method includes providing insufflation gas and an aerosol of medication to an organ or body cavity while controlling overall pressure in the organ or cavity. The method may also include re-entering a patient through at least one port to apply gas and an aerosolized medicament, in either a post-operative procedure or in a chemotherapy context.

Abstract: A system and method for performing a surgical procedure that are based on delivering air to a surgical site to prevent contamination of a wound or surgical instrument. A curtain of air above the surgical site prevents pathogens or pathogen laden particulates eminating from sources such as the skin of health care professionals including operating room staff, room air, and ceiling from contaminating the surgical site. The curtain of air may be turbulent or laminar and heated or humidified with a solution of anti-microbial agent such as an antibiotic or anti-microbial such as triclosan. Optional incorporation of a UV or blue light source into the system may also prevent infection. The system is designed to be ergonomically compatible with existing surgical substrates such as a retractor, bed, or drape. Sources of sterile air can be brought to a manifold pivotably coupled to a shaft that is attached to a bedrail or instrument stand to deliver the air directly over a surgical site.

Abstract: Method and medical devices for generating and stabilizing micro- or nano-bubbles, and systems and methods for therapeutic applications using the bubbles, are provided. The micro-bubbles may be used to enhance therapeutic benefits such as ultrasound-guided precision drug delivery and real-time verification, acoustic activation of large tumour masses, enhanced acoustic activation through longer retention of therapeutic agents at the point of interest, enhancement of high intensity focused ultrasound treatments, light activation of photodynamic drugs at a depth within a patient using extracorporeal light sources, probes, or sonoluminescence, and initiation of time reversal acoustics focused ultrasound to permit highly localized treatment.

Abstract: This invention provides a novel surgical device well suited to use in laparoscopic or other (e.g. open surgical) procedures. In certain embodiments, the device comprises a surgical probe, including a handle comprising at least one channel passing through the handle; and at least one conduit passing through the handle, where wherein at least one effector element is inserted into or through the channel, which effector element effects one or more surgical functions; and where the conduit comprises a distal conduit port that directs gas out of the conduit to substantially remove debris and/or fluid from a surface disposed proximal to the effector and/or from the effector element.

Abstract: A method for treating conditions related to lack of blood supply with a resuscitation fluid is disclosed. The resuscitation fluid contains a lipophilic component and a polar liquid carrier. The lipophilic component forms an emulsion with the polar liquid carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen and other lipophilic gases to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.

Abstract: The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile.

Abstract: Provided is a pressurized carbon dioxide bathing apparatus for bringing carbon dioxide into contact with skin of a living body by a predetermined pressure value or more using compressed air, and thereby enabling carbon dioxide to be absorbed efficiently from the skin, and the pressurized carbon dioxide bathing apparatus is comprised of a carbon dioxide supply means 1 for supplying a mixed gas of carbon dioxide and water vapor containing one or a plurality of chemical agents, a compressed air supply means 2, and a cover suit 3 of a two-layer structure having an enclosed layer 4 that is connected to the carbon dioxide supply means 1 via a connector 6 to confine the mixed gas supplied from the carbon dioxide supply means 1 so as to bring the mixed gas into direct contact with skin of the human body and an enclosed layer 5 that is connected to the compressed air supply means 2 via a connector 7 to confine compressed air supplied from the compressed air supply means 2, where the carbon dioxide is brought into cont

Abstract: Apparatus and methods deliver physiologically active agents in the presence of adjuvant gases. The adjuvant gases can enhance the effectiveness of the drug, lower the dosage of drug or concentration of drug necessary to achieve a therapeutic result, or both. Exemplary adjuvant gases include carbon dioxide, nitric oxide, nitrous oxide, and dilute acid gases.

Abstract: A bubble-type nose cleaner includes a container, an electromagnetic pump, a nose-washing tool, and at least a bubble generating valve. The container has a containing space for storing a cleaning solution. The electromagnetic pump is communicated with the container through a negative pressure channel, thereby the cleaning solution in the container could provide fluid in the electromagnetic pump. The nose-washing tool is communicated with the electromagnetic pump through a positive pressure channel, thereby the nose-washing tool is applied with the cleaning solution drawn by the negative pressure and then discharges the cleaning solution when the electromagnetic pump actuates.

Abstract: A gas supply apparatus measures a first pressure inside a first body cavity of a specimen and a second pressure inside a second body cavity of the specimen. The gas supply apparatus regulates a pressure of a predetermined gas based on the measured first and second pressures inside the first and second body cavities so that the first and second pressures reach predetermined first and second pressure settings, respectively.

Abstract: The present invention relates to a method of treating a wound and an apparatus for promoting wound healing. An enclosure is applied over the site of a wound and filled with a physiologically acceptable rinse solution. The physiologically acceptable rinse solution treats the wound and can promote the growth of tissue cells in the wound. Following exposure to the wound, the physiologically acceptable rinse solution is analyzed by a data sensor to determine the wound bed biology.

Abstract: A system and method for creating a medicated atmosphere in an organ, or body cavity is disclosed. The system includes a flexible aerosolization catheter, a device for introducing of the aerosolization catheter, a medication delivery apparatus configured to control delivery of a medication to the catheter, a gas delivery apparatus in communication with the catheter, a gas pressure relief apparatus configured to relieve pressure in the organ or body cavity, and a central controller in communication with the medication delivery apparatus, gas delivery apparatus, and gas pressure relief apparatus. The method includes providing insufflation gas and an aerosol of medication to an organ or body cavity while controlling overall pressure in the organ or cavity. The method may also include re-entering a patient through at least one port to apply gas and an aerosolized medicament, in either a post-operative procedure or in a chemotherapy context.

Abstract: Apparatuses, systems and methods for generating, dispersing and delivering chemical compounds utilizing desorption electrospray ionization. Embodiments include an airflow channel into which an airflow is directed, a solvent reservoir containing a volume of solvent, at least one charged droplet source for producing a plurality of charged liquid droplets in the channel, and at least one grounded counter electrode positioned within the channel with the electrodes having at least one surface containing one or more chemical compounds that include releasable ions. In operation, the charged droplets are directed onto the surface or surfaces so that the impact of the charged particles on said surface produces gaseous ions of at least one chemical compound on said surface, after which the gaseous ions are dispersed into the airflow.

Abstract: A drug delivery device that aerosolizes a dry powder formulation so that it forms a fine coating in the oral cavity and, more specifically in the sublingual region of the oral cavity is described herein. In the preferred embodiment, the device contains five main parts: (i) a compressed gas canister, (ii) a dispenser body (also referred to herein as the main housing ), (iii) a means for storing one or more doses of a drug formulation, (iv) a means for releasing a dose of the drug formulation such as a gas canister or spring piston and (v) a mouthpiece. Preferred configurations include circular, tubular, and rectangular. The means for storing the drug formulation may be configured to separately store one or more materials. In one embodiment, the means for storing the active agent is in the form of one or more drug discs, where the drug discs contain a plurality of blister packs, each storing one dose of the drug formulation.

Abstract: A wound treatment system includes a vessel that is sized to receive a human limb. The vessel includes a chamber with an opening leading into the chamber A removable liner lines the chamber of the vessel and forms a treatment zone. A humidifier in fluid communication with the treatment zone humidifies a solution of water and antibacterial agent. An oxygen source is in fluid communication with the treatment zone. A speaker is coupled to the vessel and emits low frequency sound waves to the chamber. a first array of light emitting diodes that emits ultraviolet light is coupled to the vessel near the opening of the treatment chamber. A second array of light emitting diodes that emits pulsed light into the chamber is coupled to the chamber. The system also includes a control panel.

Abstract: The object of the invention is to provide an apparatus and a method for generating a large amount of nanofluid continuously and stably with a relatively simple, inexpensive and easy-to-use structure, and for efficiently performing an intra-apparatus cleaning operation to substantially reduce the nanofluid manufacturing cost. A nanofluid generating apparatus 1 for generating nanofluid containing nanobubbles, wherein the nanobubbles are gas bubbles with diameter less than 1 ?m, comprises a gas-liquid mixing chamber 7, comprising a turbulence generating mechanism for forcibly mixing supplied gas and liquid by generating turbulence, and a nano-outlet 20 for discharging the gas-liquid mixture fluid to outside of the gas-liquid mixing chamber to generate nanofluid; a gas-liquid supply apparatus 21, 23, . . .

Abstract: Methods for electrolytic oxygenation of aqueous systems, including substantially immersing an anode and a cathode in an aqueous medium, injecting oxygen into the aqueous medium, and applying a current to the electrodes.

Abstract: A mixed-gas insufflation system for mixing insufflation gases includes a gas supply providing at least two sources of insufflation gas and a mixer system. The mixer system includes a chamber having at least two inlets and at least one outlet. The at least two inlets of the chamber are in fluid communication with the gas supply. The mixer system mixes the at least two sources of insufflation gas.

Abstract: An apparatus and method for facilitating transdermal oxygen delivery is disclosed in one embodiment of the invention as including a supply source coupled to a delivery device. The supply source may provide a supply of oxygen that may be delivered transdermally through the skin of a patient via the delivery device. In selected embodiments, the delivery device may include a barrier layer to substantially retain the oxygen over a localized area of skin, and a gas-permeable contact layer to deliver the oxygen to the localized area. Finally, a transport enhancement element may increase the oxygen permeability of the localized area.

Abstract: A gas sterilizable delivery system for a two-part polymer system is provided. The delivery system includes at least two syringe barrels, each barrel being sealed with a gas permeable plunger seal allowing permeation of a sterilant gas to permeate through the plunger seal allowing the entire assembly to be gas sterilized.

Abstract: An apparatus for applying a spray to a selected site on a patient includes a sheath having a through bore extending from a first end to a second end. A flexible multi-lumen tube is secured within the sheath and has a distal portion that extends beyond the second end of the sheath. A malleable wire is positioned within at least the distal portion of the multi-lumen tube wherein manual force is exerted upon the distal portion to position the distal end in a selected position by bending the malleable wire. A housing is attached to the rigid outer sheath and has a plurality of ports for engaging a multi-tube syringe and a port for injecting a gas into the selected site wherein each port is in communication with at least one lumen. A spray nozzle is removably attached to the distal end of the multi-lumen tube wherein the at least one liquid and the gas are discharged from the multi-lumen tube and into the spray nozzle such that the aerosol exiting the spray nozzle is effective in treating the selected site.

Abstract: An ophthalmic fluid atomizer configured to safely deliver an ophthalmic fluid, the ophthalmic fluid atomizer including a body having a proximal end, a distal end and a keyed surface contour, a reservoir connected to the body within a cavity of the body, wherein the reservoir contains an ophthalmic fluid disposed therein, wherein the keyed surface contour permits insertion of the reservoir into the cavity when the reservoir is in a predetermined orientation and prevents insertion into the cavity when the reservoir is not in the predetermined orientation.

Abstract: This invention provides surgical devices and methods to apply bioactive agents to surgical sites. The devices include, e.g., a body for attachment of a pressurized fluid vessel and a reservoir of bioactive agent for controlled spraying of an aerosol of bioactive agent.

Abstract: A microsurgical system capable of improving reflux via programmable, pre-defined reflux profiles and a pressure accumulator.

Abstract: A steam-sterilizable aerosol valve has a valve body of polymeric material such as polyphenylene sulfone (PPSU) having an HDT (heat deflection temperature) at 1.8 MPa stress in the range of 200-275° C. Such a valve has the ability to survive steam sterilization without significant degradation of properties or appearance.

Abstract: A surgical apparatus for positioning within a tissue tract accessing an underlying body cavity includes a seal anchor member comprising a compressible material and being adapted to transition between a first expanded condition to facilitate securing of the seal anchor member within the tissue tract and in substantial sealed relation with tissue surfaces defining the tissue tract and a second compressed condition to facilitate at least partial insertion of the seal anchor member within the tissue tract. The seal anchor member defines a longitudinal axis, and has leading and trailing ends with at least one longitudinal port extending therebetween adapted for reception of an object whereby compressible material defining the at least one port is adapted to deform to establish a substantial sealed relation with the object. The seal anchor member may comprise a memory foam material and may include a plurality of longitudinal ports.

Abstract: A method and apparatus for delivering therapeutic or diagnostic agents as a low pressure high velocity spray into tissue. According to the particular desired spray characteristics, the spray may be generated via the combined use of pressure atomization and electrostatic spray charging, or via the combined use of pressure atomization and electrostatic atomization. Particle velocity, spray flow-rate, and spray dispersion are further controlled via electrostatic means.

Abstract: A device and a method for improved treatment of tissue by direct application thereto of desired therapeutic substances in the form of a stream of therapeutic droplets carried in a high velocity gas produced by accelerating a flow of gas through at least one gas discharge nozzle so as to provide a gas discharge flow at an elevated velocity, and introducing into the elevated velocity gas discharge flow at least one flow of therapeutic liquid, through at least one liquid discharge nozzle, thereby fragmenting the at least one flow of therapeutic liquid into a stream of therapeutic droplets, and accelerating the stream to an accelerated velocity similar to the velocity of the gas discharge flow, and then applying the accelerated therapeutic droplet stream to a tissue mass desired for therapeutic treatment thereby.