Abstract: This invention pertains to systems and components useful for infusing medications such as insulin. Typically, the components are used to deliver insulin to a diabetic patient at a site of infusion over a period of time greater than 4 days. The system components typically comprise a cannula adapted for subcutaneous insertion into a diabetic patient. The system further comprises a fluid conduit adapted to deliver the insulin solution from a medication reservoir to the site of infusion and a depot in operable contact with the fluid conduit. The depot comprises selected materials including a site-loss mitigating agent (such as heparin) which inhibits inflammation at the site of infusion, and encapsulation of the cannula at the site of infusion. The site-loss mitigating agent is not premixed with the insulin, and instead is adapted to contact the insulin solution in the depot as the insulin solution flows from the medication reservoir to the site of infusion.

Abstract: An adaptive flow rate control system for a surgical device, whereby the control system includes one or more nonintrusive sensors configured to be positioned on an aspiration conduit extending downstream from a handheld surgical device to measure flow and reduce clogging within the aspiration conduit is disclosed. The nonintrusive sensor may provide data to a controller of a handheld surgical device system to enable it to control operation of the handheld surgical device based at least in part on the data from the adaptive flow rate control system to prevent clogging of the aspiration system. The adaptive flow rate control system may also include a clog tracking module and a clog prediction module. The adaptive flow rate control system may include a wireless communication system configured to communicate with other components of a surgical device system and may communicate with a external network and resources on the internet.

Abstract: A priming system including a resilient chamber having flexible walls and a first check valve in a first fluid pathway between the resilient chamber and a fluid reservoir such that a fluid flows through the first check valve only in a direction from the fluid reservoir toward the resilient chamber and the fluid returns to the fluid reservoir through a second fluid pathway between the resilient chamber and the fluid reservoir upon compression of the walls of the resilient chamber.

Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.

Abstract: Ambulatory infusion pumps, medicament reservoirs, and medicament sealing assemblies, including a variety of trocar seal assemblies and fill plug seal assemblies, plus related components, as well as component combinations and related methods.

Abstract: A data collection device for attachment to an injection device and for collecting medicament dosage information therefrom.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: Example embodiments use hydrophilic substances to absorb moisture from the air passing through the vent cover. The vent cover is recommended to be used along with a fan to regulate the air flow through the vent cover. The vent cover has holes, and the holes are filled with the hydrophilic material (i.e., hydrogel or polyacrylamide beads). Once enough moisture from the air passes through the vent cover, the vent cover seals itself and prevents air from flowing. The hydrophilic material allows the water to evaporate over time and thus effectively removes the seal.

Abstract: A foot valve for drip chambers of medical infusion or transfusion apparatuses having an annular valve seat with which a float obturator axially displaceable between a position for closing and a position for opening the valve seat cooperates. A containment cage bush has an elastically deformable lateral wall within which the float obturator floats in a guided fashion, and the lateral wall of the containment bush and the float have respective mutually facing surfaces configured such that a radial deformation of the containment bush applies an axial thrust to the float obturator in the direction of moving it apart from the annular valve seat.

Abstract: An injection device comprising: a housing arranged to contain a liquid medicament or a medicament cartridge; an electrical coil arranged at the housing; a removable cap arranged to be removably engaged with an end of the housing; and a magnet arranged within the removable cap; wherein when the removable cap is disengaged from the housing, the magnet moves with respect to the electrical coil such that electrical voltage is induced in the electrical coil and a current is generated.

Abstract: A drug delivery device is provided comprising or adapted to receive a cartridge with an axially displaceable piston. The drug delivery device comprises a housing, a stationary capacitive sensor assembly, and a moveable indicator element comprising a surface with a code pattern detectable by the stationary capacitive sensor. The code pattern is formed from conductive markings printed onto the surface. The capacitive sensor is formed on a flexible sheet mounted at least in part to the exterior of the housing.

Abstract: A drug delivery device is provided comprising or adapted to receive a cartridge with an axially displaceable piston. The drug delivery device comprises a housing, a stationary capacitive sensor assembly, and a moveable indicator element comprising a surface with a code pattern detectable by the stationary capacitive sensor. The code pattern is formed from conductive markings printed onto the surface. The capacitive sensor is formed on a flexible sheet mounted at least in part to the exterior of the housing.

Abstract: An inserter for inserting a needle or cannula of an infusion set comprises a fixed inserter member and a movable inserter member movably connected to said fixed inserter member and adapted to receive the infusion set. The movable inserter member is movable from a first position to a second position to expose the needle or cannula. The movable inserter member is locked to the fixed inserter member in the first position to prevent accidentally exposing the needle or cannula.

Abstract: The present invention relates to a medicament delivery device comprising a housing, a power unit (24, 26, 28), said power unit comprising: an actuation element (52); which actuation element (52) is operably arranged to move inside said housing ( ) for expelling a dose of medicament; said medicament delivery device further comprising a monitoring unit (30); said monitoring unit (30) being detachably attached to said housing; at least one sensor (32, 54) arranged in said monitoring unit (30), said at least one sensor (32, 54) being operably arranged to monitor said power unit (24, 26, 28) for obtaining information regarding status of the medicament delivery device.

Abstract: Apparatus (10, 200) for the provision of TNP therapy to a wound is described, the apparatus (10, 200) including: a waste canister (22, 204) into which fluid is aspirated from a wound by aspiration pump means (44, 248) and a fluid flow path (420, 422) for at least a part of said aspirated fluid on an outlet side of said aspiration pump means (44) wherein said fluid flow path (420, 422) on the outlet side comprises a silencing system (400) having a plurality of silencing elements (402, 404, 406) therein.

Abstract: An anal irrigation system including a control unit (2) is provided. The control unit (2) is connected to an external tube (4) by an extension cord (9), so that pivoting of the control unit (2) with respect to the external tube (4) is possible.

Abstract: A valved container assembly which has a container for containing a fluid, the container extending in an axial direction and having an open front end and a valve disposed in the container. The valved container assembly is configured so that forward axial movement of the valve relative to the container is inhibited. A plunger element is disposed axially rearward of the valve and is axially moveable in the container. The plunger element is configured to increase the pressure of a fluid in a first volume of the container upon forward axial movement relative to the valve. The valve includes a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal.

Abstract: Apparatus (10, 200) for the provision of TNP therapy to a wound is described, the apparatus (10, 200) including: a waste canister (22, 204) into which fluid is aspirated from a wound by aspiration pump means (44, 248) and a fluid flow path (420, 422) for at least a part of said aspirated fluid on an outlet side of said aspiration pump means (44) wherein said fluid flow path (420, 422) on the outlet side comprises a silencing system (400) having a plurality of silencing elements (402, 404, 406) therein.

Abstract: A disposable set (5) for establishing a fluid connection between a fluid dispensing unit (17) and a dosing device adapted to dispense the fluid into a patients' vein, the disposable set comprising a length of a tubing (15) for establishing a fluid connection from the fluid dispensing unit towards and into the dosing device, wherein the tubing (15) comprises a first (1) and a second (10) tubing part, and a releasable connection (11,12), wherein the first tubing part (1) comprises two or more one-way valves (3, 24) which are provided to prevent a backflow from the patient in the direction of the fluid dispensing unit (17) in the closed position of the releasable connection.

Abstract: Drug delivery devices having non-luer connections and adapters and adaption connectors for providing non-luer connections to drug delivery devices are provided. An exemplary drug delivery device for use with a catheter connection includes a blunt needle component with a non-luer connection and a filter component with a non-luer connection, wherein the non-luer connections of the blunt needle component and filter component are incompatible with standard luer fitting and intravenous route-accessing devices. In one or more embodiments, an adapter having a non-luer connection at one end and a luer connector is provided for use with blunt needle components and filter components wherein one of the blunt needle component and the filter component includes a luer connection and the other of the blunt needle component and the filter component includes a non-luer connection. Methods of delivering liquid medication to a catheter are also provided.

Abstract: Methods and devices are disclosed to reduce the tissue trauma that occurs when a physician retracts or otherwise deforms a patient's tissues for surgery or other medical procedures. In one part, methods and devices are disclosed for cooling the tissue around the incision. In another part, methods and devices are disclosed that elute drugs into the tissues of the tissue margin. In another part, methods and devices are disclosed to engage tissues during retraction to cushion, to sense tissue state, and to modulate tissue state.

Abstract: A surgical blower for providing a directed stream to clear a surgical site, that can be used in multiple different use modes. In one use mode, the surgical blower is handheld by a user during operation. In another mode, a distal end portion of the blower is fixed to a foot of a stabilizer instrument and the handle of the blower is handheld. In another mode, a distal end portion of the blower is fixed to a foot of a stabilizer instrument and the handle of the blower is fixed to a stationary object such as a sternal retractor. In another mode, the distal end of the blower is free and the handle of the blower is fixed to a stationary object. An apparatus including a blower and a stabilizer is provided. Methods of using the blower as well as the apparatus are also provided.

Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.

Abstract: Methods and devices are provided for reducing a diabetic patient's foreign body immune response, including infusion site-loss and/or occlusion. Such foreign body responses are associated with the treatment of the diabetic patient where the treatment requires subcutaneous implantation of a foreign body, such as a cannula or catheter. In certain embodiments of the invention, a response-inhibiting agent is administered to a patient at the site of cannula/catheter insertion, thereby facilitating delivery of insulin to the diabetic patient and mitigating site-loss and/or occlusion over a period of time.

Abstract: A device for holding fluid has a spout for pouring the fluid. The device includes a lid with an aperture. The aperture can be covered by a user's fingers or uncovered to control the flow of fluid out of the spout.

Abstract: Provided are systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure source provides negative pressure to a wound dressing and a biasing mechanism provides positive pressure to a fluid reservoir.

Abstract: The invention features pharmaceutical compositions, methods, and kits featuring dosing gimens and oral dosage formulations for administration of echinocandin class compounds.

Abstract: An embodiment in accordance with the present invention provides an implanted catheter and an external device that the patient uses to inject a therapeutic into the implanted tube. The implanted catheter can be equipped with a fixation mechanism that secures the catheter in place and eases physician insertion and removal. The fixation mechanism can include shape memory arms having silicone tips or can be a second catheter branch configured to hold the device in the user's sinus cavity. The catheter can also include numerous exit holes to prevent obstruction and deliver the therapeutic. An interface between the implanted catheter and the external device is incorporated, to ensure a reliable seal for medication passage. A method and device for delivery of the catheter to the correct position can also be included.

Abstract: Some embodiments of the invention include a cannulated bone screw including a screw shaft with screw thread, a proximal end, a distal end, and a channel extending through the screw shaft. Some embodiments include an inlet port coupled to the channel and extending through the distal end, and an outlet port coupled to the channel by a curved or angled channel region. In some embodiments, the outlet port extends through the screw shaft and exits a side that is substantially parallel to the shaft longitudinal axis. In some embodiments, the cannulated bone screw can form part of a therapy delivery device. In some embodiments, the outlet port extends through a portion of the screw shaft and exits at the distal end. In some embodiments, the valve includes a plunger with a plunger rod within the screw shaft, and a valve seat for control of fluid flow out of the screw.

Abstract: An on-body injector and method of use including an on-body injector for use with an injection device. The on-body injector includes a bolus reservoir; a bolus injection needle in fluid communication with the bolus reservoir, the bolus injection needle having a bolus injection needle tip aligned with the injection port, the bolus injection needle being slideably biased away from the injection port to define a gap between the bolus injection needle tip and the injection port; and a button operably connected to the bolus injection needle to slide the bolus injection needle along the injection axis. The button is operable to advance the bolus injection needle tip to close the gap and advance the bolus injection needle tip into the injection port. The button is further operable to advance a plunger through the bolus reservoir to deliver a predetermined bolus volume to the patient through the injection flow path.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. The chemical reaction energy is provided by chemical reactions including a highly reactive electrophilic reagent provided to a target tissue location.

Abstract: A drug delivery device (100), including a body (104, 116) having a reservoir (164, 176) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (164, 176) and the patient. The device (100) also includes a needle cover (114) for selectively covering the injection needle (152), an adhesive (264) for selectively adhering the device to the patient, a release liner (500) for selectively covering a patient side of the adhesive (264), and a connecting means (112, 520, 512, 508, 524) for connecting the needle cover (114) and the release liner (500) such that removal of one of the needle cover (114) and the release liner (500) from the device (100) removes the other one of the needle cover (114) and the release liner (500).

Abstract: A method of making a delivery device (10) for therapeutic agent, drug or vaccine is disclosed. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer (20) across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.

Abstract: An ear medication delivery device for delivering a treatment liquid and retaining the treatment liquid within an ear canal of a patient.

Abstract: A large enteral feed cup large enough to contain an amount of fluid suitable for a single dose (nutrition and/or medicines) is described. The enteral feed cup can be free-standing on the proximal end so as to facilitate filling via an opening on the distal end. The distal end includes a resealable closure for an opening that can be quite large and thus can be easily filled with less chance of spillage. The free-standing design of the enteral feed cup can also allow for the cup to be used in any convenient location.

Abstract: The disclosures made herein relate to an infusion device specifically adapted for syringe injections. In one embodiment of the disclosures made herein, an infusion device comprises a body including an accessible surface having a single inlet port therein, an engagement surface having a single outlet port therein, a medication delivery channel extending between the single inlet port and the single outlet port, and an identification feature on the accessible surface of the body adjacent to the single inlet port. The single inlet port of the medication delivery channel is tapered thereby forming a funnel-shaped entry into the medication delivery channel. A cannula is coupled to the body at the single outlet port and is adapted for receiving medication from the single outlet port and transmitting the medication therethrough.

Abstract: A nasal irrigation system for rinsing nasal and sinus passages or cavities includes a solution preparation unit and a dispensing container. The solution preparation unit includes a first water reservoir, a filter that is in fluid communication with an outlet of the first water reservoir and filters water passing therethrough, a second water reservoir that is in fluid communication with the filter, and a heating element that brings filtered water in the second water reservoir to a boil to clean the filtered water, and a filler port. The dispensing container receives a nasal rinse solution from the solution preparation unit, via the filler port, and administers the nasal rinse solution to a user via a direct nostril interface. The solution preparation unit can also include a cooling element, additive reservoirs for materials to calibrate salinity or to provide a pH buffer, and a control circuit to control operation thereof.

Abstract: A reservoir for a drug delivery system is provided, wherein the reservoir comprises a cavity, the cavity being filled with a dose of a fluid drug such that the dose of the drug occupies 95% or more of the cavity, wherein the dose volume is less than 5 ml. Furthermore, a method for filling a reservoir for a drug delivery system is provided.

Abstract: A water jet spray nozzle has a flow path including, from the upstream side to the end of the flow path, a small-diameter portion having a small inside diameter, an expanded portion having a larger inside diameter than the small-diameter portion, and a jet orifice having a smaller inside diameter than the expanded portion. The water jet spray nozzle is configured such that water passing through the flow path with a pressure of 0.2 to 0.6 MPa is retained in the expanded portion to as to generate cavitation bubbles from the small-diameter portion to the expanded portion. The inside diameter of the small-diameter portion § is 0.5 to 0.7 mm while the inside diameter of the jet orifice is 1 to 1.3 times larger than that of the small-diameter portion.

Abstract: An apparatus 100 for use in tube feeding comprises a cylindrical body 110 provided with a first opening 120 and a second opening 130 connected by a flow channel 140. The body 110 comprises reagent 111, for determining a characteristic of fluid disposed in the body and a transparent window 112 through which the reagent 111 is visible. In use, a first end of an internal feeding tube releasably engages with the first opening 120. The second, distal end of said feeding tube is disposed inside a patient to be fed. A second feeding tube engages with the second opening 130. The second feeding tube connects the apparatus 100 to a bi-directional pump operable: to pump internal fluid from a reservoir, through the apparatus and into the internal feeding tube; and to pump fluid from the patient into the body 110 of the apparatus 100. This allows a user to pump fluid from the patient into the body 110 of the apparatus 100 to react with the reagent 111.

Abstract: The present invention relates to a drug delivery device defining a reservoir for containing a product, having a distal end comprising an end-piece defining a channel for the transfer of the product from the reservoir, said drug delivery device comprising means for coupling said end-piece with a connector, said coupling means comprising a collar defined around a portion of the end-piece and extending from the distal end, said coupling means comprising connection means connectable to said collar, said connection means comprising a tubular wall portion having an interface defined thereon for engagement with an internal face of said collar, and a retaining hook having engagement means engageable with at least part of an external face of said collar when said connection means is connected to said collar.

Abstract: A clam shell shaped adapter for retaining a catheter to establish a fluid path between the catheter and a fluid device or line has first and second shells integrally connected by a living hinge. The first shell has a luer end and a catheter end. A flexible tubing at an inner surface of the first shell connects the luer end to the catheter end. The catheter is inserted through the catheter end to extend along the flexible tubing. A retainer structure is provided at an inner surface of the second shell so that when the first and second shells close upon each other, the retainer structure presses against the flexible tubing to fixedly retain the catheter in a fluidly sealing manner. Respective latch mechanisms provided at the shells lockingly couple the first and second shells to each other.

Abstract: The invention provides infusion devices that utilize a low profile handle. The handle is useful in retaining a needle in, and removing the needle from, the device.

Abstract: A dialysis device according to the invention includes a hemodialyzer which is connectable to the blood circulation of a patient, a plasma storage device for temporary storage of blood plasma of the patient and a supply device for supplying blood plasma stored in the plasma storage device into the blood circulation of the patient

Abstract: A hybrid apparatus for delivery of fluid in connection with endoscopic irrigation and lens cleaning including a connector which is adaptable to a flexible or rigid container, a connector arranged at the end thereof and connected via a tubing supply to a fluid, air and or gas source and to an endoscope during a procedure.

Abstract: A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure.

Abstract: Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed.

Abstract: An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm. The valve may be attached to the bottle or it may be attached to the nozzle. The enema can be administered more easily, with a lower amount of force. A method of bowel cleansing includes inserting the enema into a rectum and applying a compression force to the enema bottle.

Abstract: Described are devices, systems, and methods for processing adipose tissue for reintroduction into a body. In some embodiments, adipose tissue is mixed with an additive prior to reintroduction.

Abstract: A feeding bag system and method of preparing a feeding system is described. The system can include an adapter cap having a threaded portion for threadbly receiving the feeding bottle, a funnel-shaped portion having a tip portion configured to cooperate with an enteral feeding tube, a vent passageway disposed through the adapter cap, and a fluid passageway disposed through the funnel-shaped portion. The system can also include a bag configured to be suspended by a medical hanger. The bag may include walls defining an inner cavity, an upper opening for positioning the feeding bottle therethrough, and a sealed lower portion. The sealed lower portion can include an aperture configured to receive a portion of the adapter cap therethrough.