Abstract: A device (10) administers a fluid (23) from a container (12) into a human cavity or animal cavity (66). The device includes a nozzle (20) configured to be placed in external contact with tissue surrounding an orifice (58) without penetrating the orifice. The nozzle includes a discharge opening (40), through which the fluid is ejected into the cavity, a base (24) disposed opposing the discharge opening, and a side wall (26) that extends from the discharge opening towards the base and configured so that the tissue surrounding the orifice conforms to the shape of the side wall to form a leaktight seal between the tissue and the orifice. An interior conduit (30) is disposed within the side wall and configured to deliver the fluid from the container to the discharge opening.

Abstract: A wearable infusion pump assembly includes a reusable housing assembly, and a disposable housing assembly including a reservoir for receiving an infusible fluid. The wearable infusion pump assembly also includes a releasable engagement assembly configured to allow the reusable housing assembly to releasably engage the disposable housing assembly. A switch assembly of the wearable infusion pump assembly is configured to effectuate a functionality of the infusion pump assembly.

Abstract: The invention is directed to a nasal delivery device comprising one or more microneedles, and to methods of nasally administering a composition with a nasal delivery device comprising one or more microneedles. In certain embodiments, the nasal delivery device comprises a substrate for administration of a composition to the nasal and/or sinus mucosa, wherein the substrate is non-absorbent and comprises one or more microneedles. In some embodiments, the nasal delivery device comprises a reservoir comprising one or more therapeutic agents, wherein the reservoir is in fluid communication with one or more microneedles.

Abstract: Described herein are cannulas having a stepped exterior. Also described are methods of making and using these cannulas, for example to deliver one or more materials to the central nervous system of an animal.

Abstract: Systems and methods for cleaning body cavities are presented. Described embodiments include systems for cleaning feces from the lower GI tract. Also provided are systems for steering such a cleaning system, also useful for steering an endoscope or other tool inserted into a body.

Abstract: A fluid infusion device that delivers medication fluid to a user includes a removable fluid reservoir having a reservoir port and a hollow fluid reservoir needle, a base plate having a reservoir port receptacle for the reservoir port and the reservoir needle, and an inlet structure in the reservoir port receptacle to define at least a portion of a fluid chamber. The fluid infusion device also includes a needle sealing element having a base section, an end section opposite the base section, a neck section between the base section and the end section, and a needle opening extending through the base section, the neck section, and the end section. A compression element is coupled around the neck section to impart an inward biasing force near the needle opening.

Abstract: A device includes at least one housing, a first input line operatively connected to a fluid source that is external to the at least one housing, and a second input line operatively connected to the fluid source. The device further includes a first fluid reservoir operatively connected to the first input line and a second fluid reservoir operatively connected to the second input line. An output line is operatively connected to the first fluid reservoir and the second fluid reservoir. An actuator is configured to facilitate a flow of fluid from the fluid source, through the first input line and second input line, and through the first fluid reservoir and second fluid reservoir. Each of the first and second input lines remains operatively connected to the fluid source during operation of the actuator.

Abstract: One embodiment of the invention relates to an apparatus comprising an input connector configured for sterile connection to a fluid source, a first tube, a second, and a third tube. The first tube extends from a proximal end to a distal end comprising an input connector configured for sterile attachment to a fluid source. The input connector provides fluid communication between the first tube and the source. The second and third tubes are each in fluid communication with the first tube. The second and third tubes each extend from a proximal end to a distal end comprising an output connector configured for sterile connection to separate fluid input ports of a catheter based device.

Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.

Abstract: A sealing assembly is utilized for a fluid infusion device that cooperates with a fluid reservoir having a reservoir port and a hollow fluid reservoir needle at least partially located within the reservoir port. The sealing assembly has a reservoir port receptacle with a proximal end, a distal end extending from the proximal end, and a needle opening formed in the distal end to receive the hollow fluid reservoir needle. The sealing assembly also has a fluid chamber located at least partially in the reservoir port receptacle, and a needle sealing element having a self-sealing needle opening formed therein. The needle sealing element is located within the reservoir port receptacle between the distal end and the fluid chamber. The the self-sealing needle opening accommodates the hollow fluid reservoir needle when the reservoir port engages the reservoir port receptacle.

Abstract: The present invention is directed towards a nasal rinsing device also known as a neti pot. The neti pot comprises a container body for holding liquid, a removable cap, and an extended pouring spout that directs a saline solution into nasal passages. The cap provides an adequate liquid-seal and venting for airflow into the interior of the pot.

Abstract: A high flow volume nasal irrigation device for alternating pulsatile and continuous fluid flow includes a tube comprising a free end and a housing at a second end adjoined to a cap with a coaxial cap nipple. A valve assembly inside the housing comprises a disk-like valve and a plurality of housing standoffs configured to stop the valve but allow a fluid flow in the housing and out the nipple. A cylindrical elastic valve seat is adjoined to the cap nipple and forms a gap with the valve on the standoffs. A spring opposes the valve moving toward the valve seat from the standoffs and assists in returning the valve from the seat to the standoffs and thus with the valve seat creates a periodic pulsatile fluid flow in the nipple in response to a chamber pressure which exceeds a critical chamber pressure threshold.

Abstract: A drug delivery system has a fluid store that has a first tubing having an outlet fitted with a connector of a given configuration that prevents the connector from being coupled to a conventional counterpart connector. The system further has a tube retaining device that has a catheter extending out of one of its ends and an inlet connector at its other end that has a configuration complementary to the configuration of the outlet connector of the first tubing, so that the first tubing may be matingly connected to the tube retaining device to establish a through fluid path from the first tubing to the catheter. A one-way valve may be provided to the tubing to prevent fluid from flowing backwards into the tubing. The tubing can be selectively occluded and opened to regulate the flow of fluid from the tubing to the catheter.

Abstract: A catheter assembly (11) includes an elongate member (14) having a proximal end (18) and a distal end (19). The distal end (19) has at least one drainage opening (15). A fluid containing member (20) is arranged on the elongate member (14). A container (12) contains the elongate member (14) and the fluid containing member (20). A method of using the catheter assembly (11) includes inserting a catheter (14) into a users body and draining fluid from the users body.

Abstract: The present invention discloses an attachment (1) for a device for enteral feeding, which comprises at least two connecting pieces (2, 5), wherein the first connecting piece (2) can be connected to the connection nozzle (3) of a feeding container (4), and the second connecting piece (5) can be connected to a transfer unit (6) so that a food flow from the feeding container through the connection nozzle and the attachment into transfer unit is made possible. Furthermore, the attachment comprises a means for opening (7) of the feeding container. Furthermore, a device for enteral feeding comprising the attachment according to the invention is disclosed.

Abstract: An ear medication delivery device for delivering a treatment liquid and retaining the treatment liquid within an ear canal of a patient including a unitary, one piece earplug formed of a soft resilient material including an ear canal engaging portion and an external portion and defining a single internal passage therethrough. The external portion includes a major disk and an annular medication applicator receiving portion in fluid communication with the internal passage. The ear canal engaging portion includes at least two minor disks of progressively different size extending outwardly in a generally radial direction. The ear canal engaging portion defines a molded resilient valve unitary with the earplug that is shiftable from a closed position to an open position in either direction under a preselected fluid pressure and that resiliently returns to the closed position below the preselected fluid pressure.

Abstract: The present invention provides implantable or insertable medical apparatuses that deliver one or more urologically beneficial agents to the urinary tract. In one aspect, the medical apparatuses comprise a reservoir, a catheter, an implantable or insertable urological medical device, and an optional pump.

Abstract: Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.

Abstract: The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.

Abstract: The invention relates to a medicament container (2), comprising a bag (3) with an outlet (4), the bag (3) compressible by a compression means (6), the bag (3) having an inner surface arranged to stick when subjected to the compression means (6). The invention also refers to an arrangement (1) for administering a liquid medicament (M) comprising the medicament container (2) and a compression means (6) for locally compressing the bag (3).

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: An ear implant electrode device is described. An implantable electrode array has an outer surface with electrode contacts for electrically stimulating adjacent neural tissue. There is a fluid delivery channel within the electrode array for delivering a therapeutic fluid through one or more fluid delivery ports on the outer surface. A temporary fill tube is connected to the fluid delivery channel for providing the therapeutic fluid when the electrode array is partially inserted into a patient neural tissue without being functional after the electrode array is fully inserted. At least a portion of the fill tube is adapted for removal after providing the therapeutic fluid to have the fluid delivery channel and any remaining portion of the fill tube completely enclosed within the neural tissue after the electrode array has been fully inserted so as to leave no exposed fluid opening outside the neural tissue.

Abstract: A flexible container for storing a liquid medicament comprises a container wall consisting of two wall sheets of flexible material that are sealed together is disclosed. The container may comprise a storage compartment for the liquid medicament, and an access opening on one of the wall sheets. The storage compartment and the access opening may be in fluid connection. The access opening is designed to be fluidly connected to an outer conduit system. An insert part may be arranged between the two wall sheets with positive locking, and may fluidly connect the storage compartment and the access opening.

Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament contained within a capsule having an integral flow distributor/distribution system and where both medicaments are delivered through a single hollow needle.

Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.

Abstract: A disposable set (5) for establishing a fluid connection between a fluid dispensing unit (17) and a dosing device adapted to dispense a fluid into a patient's vein. The disposable set comprises a length of tubing (15) having a first (1) and a second (10) tubing part. The first tubing part (1) having a one-way valve (3) which permits a fluid flow from the dispensing unit (17) towards the dosing device and to prevent a backward fluid flow from the dosing device towards the dispensing unit. The first and second tubing part are in fluid connection with each other by means of a releasable connection device (11, 12), which is adapted to permit a back flow from a patient in a released position of the releasable connection device and to prevent a back flow from the patient in a closed position.

Abstract: The present disclosure provides cassettes and methods of using same for the delivery of fluids to a patient using fluid delivery systems. In a general embodiment, the cassettes of the present disclosure include a flexible tube, a housing having a recessed area and first and second ends for holding the flexible tube, and at least two additional components including, for example, different sensors, false reading components for sensors, anti-flow valve means, insertion guides, directional indicators, latch mechanisms, kink-prevention notches, etc. Such additional components provide the cassettes of the present disclosure with several advantages including, for example, quality control, efficiency of use, cost effectiveness, and safety of use.

Abstract: The invention concerns a base part for a medication delivery device. The base part is during use fastened to a patient's skin and connected to a cannula part which cannula part is positioned at least partly subcutaneous. The base part is also connected to a sensor unit which can detect one or more components e.g. glucose content in the patients blood. The base part comprises fastening means (15) which fastening means (15) releasably attach the reservoir/delivery part to the base part during use and a first fluid path or means corresponding to a first fluid path from a reservoir permitting a flow of fluid between the reservoir/delivery part and the base part when the reservoir/delivery part is attached to the base part, the first fluid path comprises means (17) for interrupting the fluid flow when the detachable reservoir/delivery part is not attached to the base part (1) and opening the fluid path (19) when the delivery part is attached to the base part (1).

Abstract: A nozzle for a nasal rinse device including a collar that forms a conduit. The collar is configured to attach the nozzle to the nasal rinse device. An outlet aperture defined by the collar is on a top portion of the nozzle. The nozzle also includes a skirt extending outwards and downwards from the collar, and an outer surface of the skirt is faceted.

Abstract: An assembly for a fluid transfer system includes: a connector having a proximal end and an opposite distal end connected by an inner passage; and a container having an internal fluid reservoir. The connector is coupled to the internal fluid reservoir of the container to form a series fluid connection between the inner passage and the internal fluid reservoir, and the connector and the container are made of a biodegradable material.

Abstract: Partially collapsible bottles (10) for providing nutritional compositions and other fluids and methods of using the partially collapsible bottles are provided. In a general embodiment, the present disclosure provides a bottle (10) having a rigid wall (20), and a semi-rigid wall (30). The semi-rigid wall (30) is constructed and arranged to conform to an inner side of the rigid wall (20) in a collapsed form. The bottle (10) can be sized to hold any suitable volume such as, for example, from about 100 to 5000 mL.

Abstract: Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

Abstract: A device for retaining and dispensing a free-flowing substance includes a syringe-like retaining body (12) in which a retaining space (46) is formed. A displaceable piston (22) is axially introduced into the retaining space (46) and the retaining body (12) is provided with a dispensing nozzle (18) on its front end facing away from the piston (22). A locking pin (36) through which at least one transverse channel (44) passes, with an axial channel (42) branching off therefrom, is provided on the inside of the dispensing nozzle (18). In a closed position of the locking pin (36), a flow connection between the retaining space (46) and the transverse channel (44) is blocked. In an activation position of the locking pin (36), the transverse channel (44) is connected to the retaining space (46), so that the free-flowing substance can be dispensed from the retaining space (46) via the transverse channel (44) and the axial channel (42).

Abstract: An irrigation device that includes a reservoir for an irrigating liquid, a catheter in liquid communication with the reservoir, a fixation member for fixation of the catheter and a control unit. The control unit is arranged for in a first position transferring the irrigation liquid to the fixation member and in a second position transferring the irrigation liquid to the catheter. Thereby is provided a simple, inexpensive and essentially maintenance free device which can be used for administrating an irrigation liquid, and which at the same time comprises a fixation member that will not be expelled from the body cavity by e.g. a peristaltic reflex, during use.

Abstract: A lubrication device for lubricating a joint of a human or mammal patient, which is entirely implantable in a patient's body, comprises a reservoir for storing a lubricating fluid and a fluid connection for introducing the lubricating fluid into the joint when the device is implanted in the patient's body. Further, the fluid connection comprises a fluid connection device connecting the reservoir with the joint such that a lubricating fluid flow is established from the reservoir into the joint. The fluid connection comprises either an infusion needle adapted to be intermittently placed into the joint for injecting the lubricating fluid, or a tube adapted to be permanently placed into the joint for continuously injecting the lubricating fluid.

Abstract: Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Extracorporeal devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an inflammatory disease or condition in the subject.

Abstract: An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm. The valve may be attached to the bottle or it may be attached to the nozzle. The enema can be administered more easily, with a lower amount of force. A method of bowel cleansing includes inserting the enema into a rectum and applying a compression force to the enema bottle.

Abstract: Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.

Abstract: An infusion data communication system provides a communication link among a fluid container, an infusion pump, and a patient through which identification data may be communicated. Data devices are located at the fluid container and the patient and conduct low frequency RF energy at a low power level containing the data into the medical fluid. The data-laden RF energy propagates through the medication fluid to data readers at the infusion pump which receives the RF energy and reads the data. A comparison is made to verify that the right medication is mounted to the infusion pump for administration to the right patient. RFID devices may be used for the data devices and readers. Pump programming data may also be propagated to the infusion pump from the container RFID tag. The RFID device at the patient may be writable and may be used to store a patient MAR.

Abstract: This application is directed to methods and kits for preventing the spread of sexually transmitted microorganisms among individuals. The present method is for the application of a medicament comprising an irrigant to an area of the body having, or which may have, a lesion resulting from, for example, a viral, bacteria or fungal infection, thereby damaging the microorganism within the lesion and preventing the organism from infecting human cells.

Abstract: An applicator for use in tissue repair is provided. The applicator includes a base configured to dispense a material and an applicator tip operably connected to the base. The applicator tip includes a body having a distal end configured to engage a tissue defect and a mold disposed about the body configured to engage tissue about the tissue defect. The mold is configured to be selectively positioned about the distal end of the body between at least a first position and a second position to deposit material to form at least a first layer and a second layer. Also provided are applicator tips, methods and kits for tissue repair.

Abstract: An assembly comprises a drug delivery device and a monitoring device adapted to detect an action taking place in the drug delivery device. The drug delivery device comprises a main portion having a drug expelling mechanism for expelling drug from a reservoir through an outlet, a housing in which at least a portion of the expelling mechanism is arranged, and coupling means for a cover. The cover is adapted to cover the outlet when mounted on the main portion. The monitoring device comprises a housing portion, means for detecting an action taking place in the drug delivery device, and coupling means adapted to engage the coupling means on the main portion. By this arrangement the monitoring device can be placed in a pre-determined position relative to the main portion when the coupling means engage each other, this allowing efficient transmission of information between the monitoring device and the main portion.

Abstract: An otoscope kit has an otoscope with an attachable ear wax removal device for ear wax removal. A fluid dispensing means which is attachable to the otoscope for ejecting fluid through said ear speculum into the ear canal, the fluid dispensing means being mounted on the gripping body of the otoscope. The fluid dispensing means preferably includes a housing, a fluid supply and dispensing container, a pump, a tube connected to the fluid supply and dispensing container at one end extending and connected to a connector on a speculum cover. The fluid dispensing means is controlled by an actuator switch that is mounted in an opening of said housing wherein the actuation of the fluid dispensing means occurs without blocking the line of sight through the viewing means. The fluid dispensing means further can have a fluid recovery means having a vacuum pump, a fluid and debris recovery container and a tube for connecting the fluid recovery container to a second connector in the speculum cover.

Abstract: The present invention relates to a portable kit and methods for administering a therapeutic dose of autologous plasma to an injured person.

Abstract: A pressure actuated flow control valve for an infusion catheter permits gravity flow of a liquid through the catheter and into a patient while resisting back flow of blood from the patient and into the catheter. The valve has a hemispherical body with an outstanding circumferential flange and a normally closed, diametric slit. The slit is longer on the convex outer surface than on the concave inner surface. Dome thickness diminishes in the area adjacent the slit, reducing total apical deflection upon collapse of the slit toward the concave surface. An inner orthogonal rib biases the slit closed. Upon application of a predetermined pressure, the slit opens toward the concave surface to permit forward fluid flow. At lower pressures, the slit closes to check fluid flow. Greater reverse pressure is required to collapse the slit toward the concave surface to permit reverse fluid flow.

Abstract: A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure.

Abstract: Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of the user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The saline solution source is disposed relative to the device to provide gravitational inducement of saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and the relative vacuum from the effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of a user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils.

Abstract: A dispenser head for mounting on a fluid dispenser, said dispenser head comprising a body (1) provided with a dispenser orifice (10), said head being provided with a cap (2) that is displaceable between a closed position, in which it covers said dispenser orifice (10), and an open position, in which it does not cover said dispenser orifice, said cap (2) being connected in permanent manner to said body (1), regardless of the position of said cap.

Abstract: The present apparatus is an IV line preparation device including a cap and a chamber cartridge for collecting fluid that needs to be expelled from an IV line before it is inserted into a patient.