Body Piercing Condit (e.g., Needle, Etc.) Patents (Class 604/272)
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Publication number: 20130267914Abstract: A vascular filter system and method are disclosed. In one embodiment, the filter system comprises a dispensing needle releasably attached to a filter dispenser which stores a length of filter wire. The filter wire dispenser has a guide tube which guides the filter wire into the needle and then into a vein during surgical implantation. The filter wire is configured to coil into a predetermined shape as it is deployed from the needle. The shape of the filter wire captures blood clots in the blood stream. The filter wire is configured with a perforated section and a non-perforated section. Perforations are in fluid communication with an inner hollow lumen in the filter wire. A hub assembly attaches to an end of the filter wire that is external to the body to provide a port into the lumen for application of medication into the lumen and out the perforations.Type: ApplicationFiled: May 30, 2013Publication date: October 10, 2013Inventors: Stanley Batiste, Steven Achstein
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Patent number: 8551059Abstract: A spinal cannula with a needle hub having a transparent area for observing the liquor flowing through a hollow cavity of the needle hub. A structure for refracting or reflecting rays of light is provided in or at the transparent area of the needle hub. The structure for refracting or reflecting rays of light may be formed as one or more prisms.Type: GrantFiled: April 8, 2009Date of Patent: October 8, 2013Assignee: B. Braun Melsungen AGInventors: Andreas Katerkamp, Volker Schumacher, Robert Klug, Martin Sippel
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Publication number: 20130261567Abstract: My invention is improving the hemodialysis fistula needle as depicted as FIG. 1. In doing this I am replacing a non coagulant type of material used at the base of a needle with a coagulant type substance. This will help to reduce leakage from around the insertion site of the needle. For clarification purposes the needle is connected at the top of the hemodialysis fistula needle and the coagulant substance located at the base of the needle. Once the needle breaks through the skin, it must penetrate until the base of the needle is touching at least the epidermis part of the skin. When this happens, if any blood leaks from around the needle, the coagulant substance coagulates the blood which in turn reduces leakage.Type: ApplicationFiled: March 29, 2012Publication date: October 3, 2013Inventor: John Lewis Hogan, III
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Publication number: 20130253448Abstract: A needle used for injecting viscous materials into a patient is provided. The needle would attach to a syringe. The needle end, although pointed, is blocked or stopped so that no fluid may exit. Along the barrel of the needle is a plurality of openings through which the viscous material or other medicament would be discharged into the patient. These openings may be circular, elliptical, square, rectangular or other geometric shapes. Certain sizes of the apertures and distance from one aperture to another are disclosed.Type: ApplicationFiled: March 7, 2013Publication date: September 26, 2013Inventors: Steven Baron, Richard Arote
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Publication number: 20130253447Abstract: A needle and needle system that aids in determining needle position with respect to an implanted device. The system determines needle position by detecting changes in electrical characteristics and the system further may generate a cue to indicate proper needle placement within an implanted device. Methods for detecting needle position with respect to an implanted infusion device are also disclosed.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Inventors: Brian W. Ball, Keith A. Miesel, Mary M. Morris, Luis E. Fesser, Jonathan P. Bogott
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Patent number: 8540686Abstract: This present disclosure provides a non-coring vial access cannula which has sufficient structural strength that it may be made from a thermoplastic resin instead of metal, thus reducing the likelihood and severity of operator injury by an accidental needle stick. The vial access cannula of the present disclosure has (i) a needle hub suitable for receiving a hypodermic syringe or an IV set (e.g., a Luer lock), (ii) a cannula portion having a centrally disposed lumen, wherein the centrally disposed lumen terminates in one or more distal openings and is in fluid communication with the needle hub, and (iii) a solid tip member distal to the one or more distal openings, wherein the solid tip member has a blade with a cutting edge.Type: GrantFiled: March 2, 2005Date of Patent: September 24, 2013Assignee: Covidien AGInventor: Gregory A. Steube
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Publication number: 20130245569Abstract: An implantable drug delivery accessory is described. A middle ear guide member has a hollow interior enclosed by a non-permeable outer surface. A proximal end of the middle ear guide member is fixed to the tympanic membrane of an implanted patient. A distal end of the middle ear guide member penetrates through a fluid-tight sealed opening into the inner ear. An inner ear holding member has a proximal end connected to the distal end of the middle ear guide member at the sealed opening and a closed distal end terminating the inner ear holding member some predetermined distance within the cochlea. A hollow interior of the inner ear holding member contains a replaceable drug delivery member which stores a therapeutic drug. A semi-permeable outer surface of the inner ear holding member is connected to a cochlear implant electrode and adapted to release therapeutic drug from the hollow interior into adjacent tissue.Type: ApplicationFiled: March 5, 2013Publication date: September 19, 2013Applicant: MED-EL ELEKTROMEDIZINISCHE GERAETE GMBHInventors: Claude Jolly, Anandhan Dhanasingh, Pavel Mistrik, Soeren Schilp, Roland Hessler, Kenneth Mugridge
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Patent number: 8535279Abstract: A Huber needle assembly includes a needle, a safety tube substantially around at least a portion of the needle, and a skin plate at one end of the safety tube. The safety tube is adapted to irretractably extend over the needle.Type: GrantFiled: July 29, 2010Date of Patent: September 17, 2013Assignee: Medical Components, Inc.Inventors: Timothy M Schweikert, Doreen Kibblehouse
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Publication number: 20130237932Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.Type: ApplicationFiled: November 28, 2011Publication date: September 12, 2013Applicant: Sanofi-Aventis Deutschland GmbHInventors: Thomas Urs Thueer, David Richard Mercer, Garen Kouyoumjian, Malcolm Stanley Boyd
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Publication number: 20130237931Abstract: An access device places a medical article within a body space of a patient. The device has a needle section that includes an elongated body and a needle hub. The device further includes a dilator portion that has a dilator and a dilator hub. The dilator is coaxially disposed and slideable over the elongated body of the needle section. The device further includes a sheath section that has a sheath and a sheath hub. The sheath is coaxially disposed and slideable over the dilator. The device further includes a first locking mechanism operably disposed between the needle hub and the dilator hub to inhibit at least unintentional axial movement between the needle section and the dilator portion and a second locking mechanism operably disposed between the dilator hub and the sheath hub to inhibit at least unintentional axial movement between the dilator portion and the sheath section.Type: ApplicationFiled: January 22, 2013Publication date: September 12, 2013Applicant: ACCESS SCIENTIFIC, INC.Inventors: Michael Tal, Janelle Anderson, Benjamin k. Yaffe, William J. McCreight, Robert Rabiner, V
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Patent number: 8529494Abstract: An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.Type: GrantFiled: September 11, 2012Date of Patent: September 10, 2013Assignee: Ivantis, Inc.Inventors: Charles L. Euteneuer, Thomas R. Hektner, Andrew T. Schieber, John Wardle
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Patent number: 8529541Abstract: An infiltration cannula and method of using the infiltration cannula during a tumescent infiltration procedure are disclosed herein. The infiltration cannula may have an outwardly flaring hub which may be wedged into an adit of a patient to minimize leakage of fluid being infiltrated into the patient. Also, the infiltration cannula may be utilized to hydrate a dehydrated patient by a medically untrained person. The infiltration cannula may also be used to deliver an antibiotic/vasoconstrictive drug solution to minimize surgical site infections.Type: GrantFiled: December 20, 2011Date of Patent: September 10, 2013Inventor: Jeffrey A. Klein
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Publication number: 20130231617Abstract: A syringe body/needle assembly and a method for producing such a syringe body/needle assembly are provided that if free of an organic adhesive bond.Type: ApplicationFiled: August 30, 2011Publication date: September 5, 2013Applicant: SCHOTT AGInventors: Bernd Hoppe, Daniela Seiler, Andreas Roters, Katrin Schellenberg
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Patent number: 8517994Abstract: According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., an elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). The device (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. The invention also provides a method of treatment for morselizing and removing tissue from within the patient and creating a void within the patient and introducing a therapeutic agent and/or a bulking agent into the void.Type: GrantFiled: September 29, 2010Date of Patent: August 27, 2013Assignee: Boston Scientific Scimed, Inc.Inventors: Jianmin Li, Weenna Bucay-Couto
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Patent number: 8518000Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.Type: GrantFiled: February 27, 2009Date of Patent: August 27, 2013Assignee: DEKA Products Limited PartnershipInventors: Larry B. Gray, Eric Yeaton
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Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
Patent number: 8521259Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.Type: GrantFiled: February 18, 2004Date of Patent: August 27, 2013Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Evgenia Mandrusov, Murthy V. Simhambhatla, Syed Hossainy, Eugene T. Michal, Charles Claude, Jessica G. Chiu -
Publication number: 20130218102Abstract: A medical hollow needle structured in accordance with the present invention, wherein the puncture resistance of a blade surface over the entire length in the puncture direction can be made substantially equal, and the patient's pain during needle puncture can be relieved due to a reduction in the peak level of puncture pain with the duration of sensory awareness of the puncture pain shortened by the use of the blade surface in a novel shape employing, in combination with each other, first to fourth inclined surfaces having specific inclination directions. Accordingly, the present invention provides a medical hollow needle with a blade surface in a novel shape whereby the puncture pain can be further reduced compared to needles with a conventional structure, and to provide a preferred method of producing such a medical hollow needle.Type: ApplicationFiled: November 29, 2011Publication date: August 22, 2013Applicant: NIPRO CORPORATIONInventors: Yoshiharu Iwase, Yutaka Eizumi
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Publication number: 20130218088Abstract: A method and system of delivering a first medicament to a first injection depth and a second medicament to a second injection depth using a single dispense interface. An example medicated module is attachable to a drug delivery device, where the drug delivery device includes a drug reservoir holding a first medicament. The medicated module includes a needle cannula having a sidewall, at least one micro-hole in the sidewall of the needle cannula, and a flexible membrane sealably fixed to an inner surface of the needle cannula. The flexible membrane holds a second medicament between the flexible membrane and a portion of the sidewall having the at least one micro-hole. The first and second medicaments can be delivered to two, axially separate injection depths.Type: ApplicationFiled: October 31, 2011Publication date: August 22, 2013Applicant: Sanofi-Aventis Deutschland GmbHInventor: Daniel Thomas De Sausmarez Lintell
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Patent number: 8512291Abstract: An anti-clogging catheter includes a tubular cannula defining a fluid passageway and shaped and tipped to removably insert within and be removed from a human body, where the cannula has a proximal end with a first interior surface defining a first interior diameter and a distal end with a second interior surface defining a second interior diameter that is smaller than the first interior diameter. A stylet is movable within the fluid passageway between the proximal end and the distal end and has an outer diameter substantially equal to the second interior diameter.Type: GrantFiled: September 16, 2009Date of Patent: August 20, 2013Assignee: Engineering Resources Group, Inc.Inventor: Christopher D. Ross
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Publication number: 20130211379Abstract: A catheter assembly comprises a catheter including a catheter wall and a lumen extending lengthwise of the wall. The wall has inner and outer surfaces. The wall includes plural openings that extend through the wall and communicate with the lumen. An elongated hollow needle includes a proximal end portion and a distal end portion. The needle is movable in the lumen to move the distal end portion between the openings. The distal end portion is directed radially outward so as to extend into an adjacent opening. The distal end portion has a configuration that stores potential energy when in the lumen. The potential energy is converted to kinetic energy to produce movement of the proximal end portion as the distal end portion moves from the inner surface of the catheter wall across an edge of an opening. The movement of the proximal end portion is haptically perceptible.Type: ApplicationFiled: February 15, 2013Publication date: August 15, 2013Applicant: THE CLEVELAND CLINIC FOUNDATIONInventor: THE CLEVELAND CLINIC FOUNDATION
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Patent number: 8506530Abstract: An array for placement on the skin of a human or animal patient for the purpose of the transdermal application of pharmaceuticals, toxins or active agents, having microneedles that are situated on a carrier substrate, the microneedles having a preset breaking point in the area of the transition to the carrier substrate.Type: GrantFiled: August 29, 2007Date of Patent: August 13, 2013Assignee: Robert Bosch GmbHInventors: Franz Laermer, Michael Stumber, Dick Scholten, Christian Maeurer
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Publication number: 20130204131Abstract: Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.Type: ApplicationFiled: February 19, 2013Publication date: August 8, 2013Applicant: MERCATOR MEDSYSTEMS, INC.Inventor: Mercator MedSystems, Inc.
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Publication number: 20130204124Abstract: A surgical system includes a flexible steerable needle and a shape sensor for measuring the shape of the needle. The surgical system can be manual (e.g., laparoscopic), robotic, or any combination of the two. By directly measuring the shape of the needle, complex and potentially inaccurate modeling of the needle to determine trajectory and insertion depth can be avoided in favor of much more robust direct measurement and modeling of needle shape and/or pose.Type: ApplicationFiled: January 28, 2013Publication date: August 8, 2013Applicant: Intuitive Surgical Operations, Inc.Inventor: Intuitive Surgical Operations, Inc.
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Publication number: 20130195970Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: August 1, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Patent number: 8496628Abstract: A needle-based medical device including a needle guide and a method for constructing the same are disclosed. The needle-based medical device includes a tube having a first lumen; a needle guide which is dimensioned to be inserted into the lumen of the tube, and a needle. The needle is inserted such that an end is positioned in the needle guide. A glue may also be provided to secure the needle guide to the tube. In one embodiment, the tube may be made of extruded plastic.Type: GrantFiled: September 28, 2006Date of Patent: July 30, 2013Assignee: Erskine Medical LLCInventor: Timothy J. Erskine
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Publication number: 20130190614Abstract: A medical needle, kit, and pharmacological composition of matter comprising a local anesthetic pertaining to inserting a needle percutaneously in a patient is disclosed. A method is disclosed with the needle having a leading apex that is dulled to restrict penetration through articular cartilage, advancing the needle leading apex into a bone joint and stopping said needle leading apex short of substantially penetrating bone joint articular cartilage, and injecting through the needle lumen a pharmacological composition of matter comprising a local anesthetic and out of said opening and into the bone joint to contribute to the anesthetizing of nerves near said bone joint.Type: ApplicationFiled: January 20, 2012Publication date: July 25, 2013Inventor: John Swofford
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Publication number: 20130189353Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 25, 2013Applicant: Rani Therapeutics, LLC.Inventor: Mir Imran
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Patent number: 8491534Abstract: It is an objective to provide a microneedle and a microneedle array formed from a self-dissolving base which can realize higher absorption efficiency and a higher pharmacological availability. A preparation 1 for body surface application has two sections divided in the insertion direction, namely, an acral portion 5 and a rear end portion 6. The acral portion 5 is a section including a body surface insertion end 2, and holds a target substance soluble in base. The rear end portion 6 is a section including a pressing end 3, and is formed mainly only from the base. The rear end portion 6 does not hold the target substance.Type: GrantFiled: November 21, 2008Date of Patent: July 23, 2013Assignee: Bioserentach Co., Ltd.Inventor: Kanji Takada
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Publication number: 20130184541Abstract: An infusion set component of a fluid infusion device and/or a fluid infusion port component for delivery of fluid to a patient is compatible with a cooperating fluid channel module. The fluid channel module includes a body section having coupling features to mate with a base of the component. The fluid channel module also includes an interior fluid flow channel formed within the body section to receive fluid from the fluid infusion device and/or from a syringe or pen delivery device. The fluid channel module also includes a conduit having a first end in fluid communication with the interior fluid flow channel, and having a second end to deliver the fluid to the patient.Type: ApplicationFiled: May 3, 2012Publication date: July 18, 2013Applicant: MEDTRONIC MINIMED, INC.Inventors: David Christopher Antonio, Sumona Nag Adhya, Jose J. Ruelas, Eric Allan Larson
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Publication number: 20130184660Abstract: Provided are catheters useful for penetrating the vascular wall and delivering medicament as necessary to tissue proximate the vasculature. Such catheters are particularly useful in delivering site specific medicaments to the tissue which can be damaged by hemorrhagic stroke, ischemia, and the like. Methods of using such catheters are also disclosed.Type: ApplicationFiled: December 19, 2012Publication date: July 18, 2013Applicant: WALKILL CONCEPTS, INC.Inventor: Walkill Concepts, Inc.
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Publication number: 20130184609Abstract: The present invention provides a method for creating a beveled needle or a blade. The method employs a side wall surface of an angled post as a base to control beveled tip geometry. The invention provides needles, microneedle arrays, blades and microblade arrays with sufficient sharpness and toughness.Type: ApplicationFiled: July 20, 2012Publication date: July 18, 2013Applicant: University of Utah Research FoundationInventors: Sung K. Lee, Charles L. Thomas
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Patent number: 8486027Abstract: Apparatus are disclosed for intraosseous fluid infusion or aspiration of bone marrow of a subject. Particular apparatus include a bone portal (bone-penetrating member) comprising axially-aligned distal and proximal sections. The proximal section extends in a distal direction from a proximate end of the bone portal and the distal section extends in the distal direction from the proximate section to the distal end of the bone portal. The bone portal also comprises a fluid-transport bore extending between a proximal opening in the proximal section and a distal opening in the distal section. At least a portion of the distal section has a cross-sectional area, perimeter, diameter and/or dimension greater than that of the proximal section.Type: GrantFiled: February 5, 2008Date of Patent: July 16, 2013Assignee: Pyng Medical Corp.Inventors: Judith M. Findlay, David L Johnson, Misha Krasnich, Michael W Jacobs
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Patent number: 8486018Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.Type: GrantFiled: November 25, 2009Date of Patent: July 16, 2013Assignee: DEKA Products Limited PartnershipInventors: Dean Kamen, Larry B. Gray, Russell H. Beavis
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Patent number: 8486022Abstract: A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.Type: GrantFiled: July 3, 2008Date of Patent: July 16, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Florian N. Ludwig, Shubhayu Basu
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Publication number: 20130177527Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 11, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130177550Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 11, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Patent number: 8480626Abstract: Catheters assemblies having structural configurations operable to reduce backflow along the catheter assembly track, and methods of making and using such catheter assemblies. Catheters assemblies in accordance with embodiments of the present invention find use in various applications including the treatment of acute and chronic medical conditions. An exemplary catheter assembly includes, in one illustrative embodiment, a flexible proximal catheter body portion, and a distal portion of a smaller diameter than the body portion. The distal portion includes a sealed distal tip or end and one or more side flow openings to permit flow of therapeutic substance from the catheter along an axis that is different than, e.g., skewed relative to, a longitudinal axis of the distal portion of the catheter assembly.Type: GrantFiled: November 24, 2008Date of Patent: July 9, 2013Assignee: Medtronic, Inc.Inventor: Brian D. Nelson
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Publication number: 20130171247Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 4, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130171246Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 4, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130172828Abstract: A medical device may include an end effector configured to perform a therapeutic procedure. The medical device may further include a guide having a modifiable shape. The guide may be adapted for insertion through a lumen of an access tube. Also, the end effector may be selectively attachable to the guide and configured to move along the guide.Type: ApplicationFiled: December 26, 2012Publication date: July 4, 2013Inventors: Gary S. Kappel, Paul Smith, Larry Stanton, Ruth Cheng, Kenneth R. Keene, Gerald R. Heller, Man Nguyen
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Publication number: 20130171244Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 4, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130172257Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 4, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130171245Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: July 4, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130165859Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 25, 2012Publication date: June 27, 2013Applicant: InCube Labs, LLCInventor: Mir Imran
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Publication number: 20130165373Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: June 27, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130165372Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: June 27, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130165872Abstract: A method for producing silicon microneedle arrays with drilled holes includes producing a silicon microneedle array. For each microneedle in a plurality of microneedles in the microneedle array, a laser is positioned relative to a microneedle and a drilled hole is drilled into the microneedle array by laser drilling. The drilled holes are drilled in microneedles, in flanks of the microneedles or alongside microneedles. A microneedle array includes a substrate composed of a micromechanical semiconductor material. The microneedle array has microneedles that project from the substrate and has drilled holes. The microneedles are composed of a porous micromechanical semiconductor material.Type: ApplicationFiled: December 6, 2012Publication date: June 27, 2013Applicant: Robert Bosch GmbHInventor: Robert Bosch GmbH
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Publication number: 20130164371Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: June 27, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130164373Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: June 27, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran
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Publication number: 20130164372Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: June 29, 2012Publication date: June 27, 2013Applicant: Rani Therapeutics, LLCInventor: Mir Imran