Abstract: Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.

Abstract: An offloading and reduced-pressure treatment system includes an offloading and reduced-pressure treatment device, which has a plantar member formed from an offloading manifold material. The offloading and reduced-pressure treatment system further includes a reduced-pressure interface fluidly coupled to the pressure-transmitting layer of the plantar member, a reduced-pressure source, and a reduced-pressure delivery conduit fluidly coupled to the reduced-pressure source and to the offloading and reduced-pressure treatment device. The offloading manifold material includes a first barrier layer, a support layer, a pressure-transmitting layer and a second barrier layer. The offloading and reduced-pressure treatment device may also have a dorsal member and a bridge member. Methods are also presented.

Abstract: A method of determining an amount of skin agent transferred from an absorbent article to an area of human skin is provided. An absorbent article is applied to and then after use removed from an area of skin. Tape is then releasably attached to and removed from the area of skin. The amount of skin agent that adheres to the tape is then analyzed to determine the amount of skin agent transferred to the area of skin.

Abstract: A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix. The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

Abstract: Compositions and methods for delivery of medicaments to human or animal skin, for example, the scalp, comprising the steps of transporting the medicaments in a volatile carrier solution to a position adjacent to the skin, and atomizing the preparation at said position onto the skin to thereby uniformly distribute the preparation over the scalp thereby improving absorption of the medicament through the skin.

Abstract: A method for using a dispensing apparatus having a fluid insert with an airless channel configured for labial, vaginal, transmucosal, and transdermal delivery of a therapeutic substance is disclosed.

Abstract: The present invention relates to transdermal therapeutic systems that include an occlusive back layer impervious to an active substance, a single or multilayer matrix, and a peelable protective film. The matrix or at least one of the matrix layers includes a pharmaceutical active substance or a plurality of pharmaceutical active substances in the form of at least one pharmaceutically consumable salt thereof and a pharmaceutically consumable, alkaline reacting oxide.

Abstract: A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure.

Abstract: A method of providing moisture therapy to a subject by applying a moist therapy compress against a treated body portion. The moist therapy compress includes a fluid-permeable shell, a flexible backing fastened to the shell to define an enclosure, and a hydrophilic zeolite fill granules loosely contained within the enclosure. The therapy compress is exposed to a source of moisture to cause absorption of water into the a hydrophilic zeolite, and the moisture is delivered from the hydrophilic zeolite through the fluid permeable shell to the treated body portion.

Abstract: A device used for applying an antiseptic preparation to a surgical site of a patient prior to surgery outside of an operating theater. A loose-fitting bag is provided which encloses the surgical site by securing the open end(s) to the patient by closing means. A high friction scrub surface is provided in the bag. A method and apparatus are also provided for releasing antiseptic into the interior of the bag. The method provides that the surgical site can be scrubbed within the bag so as to properly prepare the skin for surgery. A temperature indicator for the antiseptic preparation is also provided.

Abstract: In a hyperbaric dressing a first fluid, such as oxygen, is deliverable between a fluid-impermeable layer impermeable to the first fluid and a fluid-permeable layer permeable to the first fluid. Edges of the fluid-impermeable layer and the fluid-permeable layer are sealed together and edges of the dressing are securable to a patient's skin surrounding a wound. Thus, when the first fluid is delivered, it can permeate through the fluid-permeable layer into a headspace between the dressing and the wound. A perforation is defined through the fluid-permeable layer and the fluid-impermeable layer for the passage of a second fluid, such as wound exudate. The perforation is open when a pressure in the headspace between the wound and the dressing is above a pre determined pressure and is closed when the pressure is below the predetermined pressure.

Abstract: A deodorizer device for controlling body odor comprises a structure having an external metal oxide surface with a contour to contact the surface of the skin where perspiration is produced and is degraded by bacterial organisms on the skin into body odor. The metal oxide surface is reactable with water supplied to the surface of the skin to render the bacterial organisms ineffectual to degrade perspiration later produced on the skin into body odor. The deodorizer device together with a water source form a deodorizer system. A method of controlling body odor involves supplying water to the surface of the skin where perspiration is produced and is degraded by bacterial organisms into body odor and, at the same time, contacting the surface of the skin with a metal oxide surface of a deodorizer device.

Abstract: A method of packaging and applying toxic anti-neoplastic pharmaceutical agents for the prevention and treatment of premalignant and malignant lesions of the skin is described. The packaging of liquid formulations containing these toxic anti-neoplastic agents in plastic or glass bottles with control-flow applicators and caps enables patients to apply such formulations to affected areas of skin without having to have physical contact on the part of their hands with the medicaments.

Abstract: A personal care composition comprising a multi-active system for down regulating cytokines comprising at least three actives, an extract of camellia sinesis, panthenol, and a glycyrrhizinate salt.

Abstract: A patch that is able to expedite the healing process of skin wounds such as cuts, burns, scraps, or any other superficial wounds. The present invention is an adhesive patch with gauze retaining a suds substance. The patch is applied to a user's skin wound to clean and draw out the pus and exudates for a quicker healing process.

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective irrigation of abscesses, puncture wounds, and similar types of deep tissue wounds. In one embodiment the subject invention provides a discharge apparatus for a reservoir housing containing irrigation solution, wherein the discharge apparatus has a specifically designed nozzle for insertion into a wound opening and through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: The present invention is directed to airless storage and dispensing systems that include a pump or dispensing package pre-filled with a topical semi-solid imiquimod pharmaceutical formulation (“pump systems”) and methods for storing and dispensing from the pump systems a plurality of precisely measured and uniform unit doses of a topical semi-solid imiquimod pharmaceutical formulation, and more particularly to pump systems, pre-filled with a topical imiquimod pharmaceutical cream and methods for delivering multiple precisely measured unit doses of a topical imiquimod pharmaceutical cream, and methods for using a controlled delivery pump system to store and dispense a plurality of consistent and precisely measured unit doses of a topical imiquimod pharmaceutical cream for use in topically treating a dermal and mucosal-associated condition, such as, external genital warts and/or perianal warts (EGWs), actinic keratosis or actinic keratoses (AK or AKs) and superficial basal cell carcinoma (sBCC).

Abstract: A method of applying an external dermatological medication to a skin or a skin substitute substrate with an external dermatological medication for evaluating characteristics of the external dermatological medication acquired by irradiating the skin or the skin substitute substrate with light including a first applying step of spreading the external dermatological medication in one direction on the skin or the skin substitute substrate from a side surface of the skin or the skin substitute substrate; a second applying step of spreading the external dermatological medication in a direction perpendicular to the one direction on the skin or the skin substitute substrate, wherein the first applying step and the second applying step are repeated by a predetermined number of times.

Abstract: The present invention relates to a dermocosmetic composition of localised topical application in cream and/or emulsion form, to the procedure for obtainment thereof together with use thereof for care and correction of telangiectasias and to the method of administration thereof.

Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing fluid from subjects, e.g., through the skin, including packaging associated with such systems. Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers, e.g., having an internal pressure less than atmospheric pressure. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures.

Abstract: A liquid delivery device is provided which allows for delivery of precise, small amounts of a target liquid, such as cantharadin, glycolic acid, phenol, trichloroacetic acid, or similar liquids to a specific, discrete target location, such as an area of the skin to treat conditions including, but not limited to: molluscum contagiosum, verrucous vulgaris (warts), verrucous plana (flat warts), acne scars, actinic keratosis, acrochordon (skin tags), seborrheic keratosis, dermatosis papulosa nigra, milia and lentigo (sun spots). The liquid delivery device allows for delivery of the liquid to the target area without delivering the liquid to any part of the area surrounding the precise target location, thereby eliminating unnecessary irritation such as blistering, pain, temporary or permanent tissue damage and/or scarring for the user. The liquid delivery device strongly adheres to the target liquid, eliminating spilling and the resultant danger to the user and eliminating economic waste.

Abstract: The invention relates to the treatment of wounds. In particular, the invention relates to systems, devices, and methods enabling treatment (e.g., debridement) of wounds with liquid, gas, or particles in a non-controlled setting while providing containment of contaminated liquid, gas or particles, thereby preventing exposure of individuals and surfaces in proximity to the patient to infectious materials. In certain embodiments, the systems and devices are conformable to the contours of a non-planar surface, such as the human body (e.g., to seal or partially seal the device or system to a portion of a human body).

Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.

Abstract: A dressing (2) and an apparatus (1) comprising the dressing, for cleansing the wounds (5) in which an irrigant fluid from a reservoir (12) connected to a conformable would dressing and would exudate from the dressing are moved by a device (18) (which may be a single pump or two pumps) for moving fluid through a flow Path (6, 7, 9, 10) which passes through the dressing with a means for providing simultaneous aspiration and irrigation of the wound, to provide a desired balance of fluid at a controlled nominal flow rate that removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting would healing over the would bed.

Abstract: A biocompatible wound dressing comprised of a pad for insertion substantially into a wound site and wound drape for sealing enclosure of the foam pad at the wound site. The pad, comprised of a foam or other like material having relatively few open cells in contact with the areas upon which cell growth is to be encouraged so as to avoid unwanted adhesions, but having sufficiently numerous open cells so that drainage and negative pressure therapy may continue unimpaired, is placed in fluid communication with a vacuum source for promotion of fluid drainage, as known in the art. The pad is further comprised of an ultra-low density fused-fibrous ceramic, or a bioabsorbable branched polymer, or cell growth enhancing matrix or scaffolding.

Abstract: A medicated, transdermal foot patch includes a cushioning layer, and an adhesive layer comprised of an adhesive material that adheres the patch to the skin of the foot when the patch is applied to the foot with the adhesive layer in direct contact with the skin. A removable liner is placed over the adhesive layer to protect the adhesive layer until the adhesive layer is ready to be applied directly to the skin. One or more pain-relieving compounds is deliverable to the skin when the patch is applied to the foot with the adhesive layer is in direct contact with the skin.

Abstract: Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.

Abstract: A spray delivery system in combination with a scalp medication is provided which includes a portable container having a gas imperious container wall, a pressure source disposed within the container, and a selectively operable valve assembly affixed to the container. The scalp medication is in liquid form and is disposed within the container. The scalp medication comprises a hair growth stimulation or hair growth maintenance active ingredient in an amount sufficient to stimulate or maintain hair growth disposed within a pharmacologically acceptable carrier solution. The valve assembly of the system produces a 1 mL spray of said scalp medication within about 5 seconds following a single operation of said valve assembly. A method of treating alopecia using a continuous spray employing such a system is also provided. Both bag-on-valve (bag-in-can) and metered dose packages are disclosed.

Abstract: The invention relates to a method for storing and supplying a liquid, especially a liquid medical preparation. The invention further relates to a receptacle for storing and supplying a liquid, especially a liquid medical preparation. It is an object of the invention to provide a suitable receptacle and method for storing and supplying a desired liquid quantity. The object of the invention is solved by a receptacle for storing and supplying a liquid which receptacle is liquid tight and preferably gas-tight comprising a tube or a foil bag which can be compressed. The tube or foil bag preferably comprises a rigid opening portion sealingly mounted to one end of the tube. The diameter of the opening portion preferably is the same as the diameter of the tube. The rigid opening portion is stable in respect of shape. The tube diameter preferably is not more than 10 mm and, in an embodiment of the invention, the tube contains a liquid, preferably a liquid medical preparation.

Abstract: A transdermal product delivery patch comprises a reservoir containing a product for delivery to a patient; means for affixing the patch to the skin of the patient; and manually operable means for actuating an extensor mechanism to exert pressure on the reservoir and thereby expel the product towards the skin. The patch may be supplied with the extensor mechanism held in a strained configuration and the manually operable means may be a restraint such as a peelable layer that can be removed to allow the extensor mechanism to move using stored energy towards a rest configuration. The extensor mechanism may be a ring of resilient material that is pre-stretched radially inwards so that, upon release, it stretches the reservoir radially outwards. The patch may be supplied with the extensor mechanism in a rest configuration and the manually operable means may deform it in a predefined manner into a strained configuration.

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation. In one embodiment the subject invention provides a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: A body washing device, a method for holding a washcloth using the body washing device, and a method for washing a body are provided. The body washing device includes first and second hand-held devices configured to hold a washcloth therebetween for easily cleaning portions of the body that are difficult to reach using only the washcloth.

Abstract: A system and method for rejuvenating skin through ablation using a handheld device (200) having a removable treatment component (213) with an abrasive material on one surface of the component which surface is on a portion of the treatment component (213) configured to conform to a skin surface. The system further includes application of other elements to facilitate skin recovery and rejuvenation processes.

Abstract: An enteral dispenser and associated method of use is provided for enterally dispensing liquid medications. The enteral dispenser includes a barrel having a number of dosing gradations arranged upon its outer surface. The barrel receives a liquid medication that has been selected from a predefined group of liquid medications having a range of colors. A plunger is moveably disposed within the barrel, and a piston is coupled to a distal end of the plunger. The piston has a peripheral portion for selective alignment with respect to a desired one of the dosing gradations and is a color that is optically differentiable from each of the colors represented within the range of colors of the predefined group of liquid medications, such that an user may differentiate between the color of the a peripheral portion of the piston and the color of any selected liquid medication.

Abstract: A computer-controlled system determines attributes of a frexel, an area of human skin, and applies a modifying agent (RMA) at the pixel level, typically to make the skin appear more youthful and so more attractive. The system scans the frexel, identifies unattractive attributes, and applies the RMA, typically with an inkjet printer. The identified attributes relate to reflectance and may refer to features such as irregular-looking light and dark spots, age-spots, scars, and bruises. Identified attributes may also relate to the surface topology of the skin, for more precisely enhancing surface irregularities such as bumps and wrinkles. Feature mapping may be used, for example to make cheeks appear pinker and cheekbones more prominent. The RMA can be applied in agreement with identified patterns, such as adding red to a red frexel, or in opposition, such as adding green or blue to a red frexel, according to idealized models of attractiveness.

Abstract: A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug, and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure.

Abstract: The present invention relates to an active transdermal drug delivery system performing transdermal drug delivery comprising of a patch capable of being attachable to the skin of the subject; at least one electrical energy power input; a plurality of converters/energy transducers configured for converting the electrical energy to different forms of energy; and a controller including a programmable microprocessor configured for providing the intensity, sequence, nature, and timing information for the different energies supplied and thereby providing activating signals to the said converters for the transdermal drug delivery by the said patch, and a method for performing transdermal drug delivery using said electronic patch.

Abstract: A method of topically treating the respiratory tract of a mammal with nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas nasally to the upper respiratory tract of the mammal. Also provided are several designs for a nasal delivery device for the controlled nasal deliver the nitric oxide containing gas.

Abstract: An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. microfiltration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.

Abstract: Described herein are abuse-resistant multi-layer transdermal patches comprising opioids and opioid prodrugs having a barrier layer located between the layer containing opioid or opioid prodrug and a layer containing an opioid antagonist or opioid antagonist prodrug.

Abstract: Compositions, methods and systems for treating disordered epithelial tissues, such as is caused by pathogens and/or by toxins produced thereby. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium halide compound, preferably benzalkonium chloride. The inventive compositions and methods may employ the use of an applicator adapted for use in promoting the penetration of the treatment composition and/or the vigorous agitation of the disordered tissue.

Abstract: A mucous suction device, comprising in combination, a longitudinally elongated, generally tubular, one-piece plastic body, the body having an axially elongated tapered, first portion extending toward an inlet proximate one end of the body, the body having an axially elongated second portion extending toward an outlet proximate an opposite end of the body, radially outwardly extending annular retention rings in said body second portion, said rings having sharp annular peripheries and said rings being axially resiliently flexible and axially spaced apart, and there being body side porting between said body first and second portions, said side porting being manually controllable to control suction exertion.

Abstract: A urinary anti-backflow device is provided which prevents urine from flowing back into the patient's bladder from a urine collection bag. The device comprises a flow tube having an upstream section connectable to an external urinary device secured to a patient and a downstream section connectable to a urine collection bag, a rod within the flow tube, and a stopper which moves along the rod between the downstream and upstream ends of the flow tube. When the upstream section of the flow tube is elevated relative to the downstream section, urine from the patient is free to flow through the flow tube. When the downstream section of the flow tube is elevated relative to the upstream section, urine forces the stopper against the upstream section to prevent backflow.

Abstract: A cannula support serves in supporting a cannula relative to a non-contact lens assembly and a positioning mechanism for positioning the non-contact lens assembly. The cannula support includes a cannula holder and a gripper disposed relative to the cannula holder. The cannula holder is provided for receiving at least a portion of the cannula. The gripper is adapted to cooperatively engage a portion of one of the non-contact lens assembly and the positioning mechanism.

Abstract: Methods, dressings, and systems for promoting epithelialization of a wound or other tissue are presented. The methods, dressings, and systems help form simulated rete pegs. In one instance, an epithelialization dressing is disclosed that may include a dressing body having a plurality of projections. A plurality of apertures is formed on a portion of the dressing body. The dressing helps manage fluids on the wound and the projections form cavities into which epithelial tissue migrates to from epithelial columns that function like rete pegs. Other dressings, methods, and systems are disclosed.

Abstract: An apparatus for sanitizing the skin area beneath a worn medical cast includes a thin elongate and flexible member made from a highly pliable material, the member including a distal end having at least one cleaning pad secured thereon. The thin elongate member is sized to be fitted between the skin of a cast wearer and the inner surface of a worn cast. In one version, disposable cleaning pads are releasably secured to the distal end of the elongate member.

Abstract: A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

Abstract: A device for wound irrigation which has a compressible reservoir housing with a sterile wound irrigation solution and a plurality of ports to facilitate producing a pressurized dispersed stream of wound irrigation solution.

Abstract: Test methods for assessing irritation of portions of skin and/or assessing inhibition and/or reduction of such irritation are provided.

Abstract: A method of inducing new cartilage growth from periosteum in a mammal is provided. The method includes positioning a foam manifold in contact with the periosteum and positioning a drape over the foam manifold and the periosteum to create a sealed space between the drape and the periosteum. A reduced pressure is applied to the sealed space.