Abstract: Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.

Abstract: A closing dressing bolster and assembly for use with a system for treating a linear wound on a patient includes a bolster body formed from a flexible closing bolster material having closing members that are operable to develop an inward closing force when the closing dressing bolster is placed under reduced pressure. In one aspect, when the closing dressing bolster is under reduced pressure, the system, dressing, or assembly develops an inward force realized at the linear wound and a compression force. A wicking-material holder and wicking material may be used as well. The member components may all be see-through to allow visual inspection of the wound without requiring removal of the dressing.

Abstract: Pump cassettes, wound-treatment apparatuses and methods. In some embodiments, a pump cassette comprises: a pump body having a pump chamber, an inlet valve in fluid communication with the pump chamber, and an outlet valve in fluid communication with the pump chamber; a diaphragm coupled to the pump body such that the diaphragm is movable to vary a volume in the pump chamber; and an identifier configured to store one or more properties of the pump cassette such that the identifier is readable by an automated reader to determine the one or more properties. In some embodiments, the pump cassette is configured to be removably coupled to a wound-treatment apparatus having an actuator such that the actuator can be activated to move the diaphragm.

Abstract: A single-use disposable applicator and dispenser of creams, liquids, and spreadable agents. A liquid or cream agent of liquid or viscous is stored in a sterile container. An applicator including a soft interface is stored along with the agent. When the need to apply the agent occurs, the applicator breaks the seal to the agent, after which the applicator is used to apply the cream or liquid agent to a desired surface, and is then discarded. The invention may be used by healthcare providers and similar persons to treat a plurality of persons, and lessens the likelihood that bacteria or infection will be spread amongst a population. The invention may further be used to contain, dispense, and apply any manner of spreadable agents of low rigidity including, but not limited to, soaps, cleaning agents, and paint samples.

Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.

Abstract: A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.

Abstract: Methods and devices treating an autonomic nervous system associated disease condition in a subject are provided. Aspects of the invention include inducing one or more physiological response selected from the group consisting of sweating, gastric emptying, enhanced heart rate variability and enhanced quantitative sensory test responsiveness in a manner sufficient to modify the autonomic nervous system so as to treat the subject for the disease condition. The methods and devices find use in a variety of applications, e.g. in the treatment of subjects suffering from conditions arising from disorders of the autonomic nervous system.

Abstract: A reduced-pressure treatment system for debriding a treatment area of a tissue site and applying reduced pressure is disclosed. The reduced-pressure treatment system includes a hydrogel having a blocked acid debriding agent. The hydrogel is adapted to cover the treatment area and enhance autolytic debridement at the treatment area. The reduced-pressure treatment system includes a manifold that is adapted to cover the hydrogel and distribute reduced pressure to the tissue site. The reduced-pressure treatment system also includes a sealing drape for forming a fluid seal over the tissue site and manifold. Other systems, methods, and dressings are presented.

Abstract: Disclosed are a sedative for external use, and sedative sheet, and textile, clothing, wall material, and hyperthermia equipment, brain vitalization sheet, brain vitalization small pillow which are with high productivity, adaptive for various shape and various treatment style for patients with pain, and with high treatment effect, comparing with conventional sedative for external use. A sedative for external use 10 is provided which is a bag 2 containing desert rose powder 1 prepared by pulverizing desert rose.

Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.

Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining blood clotting material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attachable to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate blood clotting material is in direct contact with blood. The mesh may include a zeolite powder impregnated or otherwise incorporated therein.

Abstract: A system and method of topically applying an anesthetic, or other medication, to one or both lips of the mouth. An applicator device is provided that has a curved first wall, a curved second wall, and a horizontal shelf that joins the first wall to the second wall. The first wall, the second wall and the horizontal shelf combine to define either one or two curved lip compartments. A volume of the anesthetic, or other medication, is placed within the curved lip compartments. The applicator device is partially placed in a person's mouth so that the second wall is positioned between the back of the lips and in front of the teeth. While in this position, the lip of the user passes into the curved lip compartment and is contacted by the anesthetic.

Abstract: Medical dressings and medical dressing kits that can be used to provide a ported medical dressing for placement over a wound or other body site where controlled fluid access is desired. The controlled fluid access provided by the medical dressings may be useful to remove fluids from the wound (as in, e.g., negative or reduced pressure therapies), to provide one or more gases to a wound site, to provide one or more liquids to a wound site, and/or to provide one or more active agents to a wound site. To achieve controlled fluid access, the medical dressing and medical dressing kits may include a port body with a lower surface that is adhesively adhered to the skin at the periphery of a wound or other body site.

Abstract: A method, and apparatus for the controlled acceleration, and/or retardation of the body's inflammatory response generally comprises a foam pad for insertion substantially into a wound site, a heating, a cooling pad for application over the wound site, a wound drape or sealing enclosure of the foam pad, the heating, and cooling pad at wound site. The foam pad is placed in fluid communication with a vacuum source for promotion of the controlled acceleration or retardation of the body's inflammatory response. The heating, and cooling provision controls the local metabolic function as part of the inflammatory response.

Abstract: Systems, methods, and dressings for treating a linear wound, such as an incision, on a patient are presented. The systems, dressings, and methods involve a sealed wound dressing assembly that helps form a fluid seal around the linear wound while simultaneously encompassing a subcutaneous delivery conduit to deliver fluid to or from a subcutaneous tissue site. In one instance, a reduced-pressure interface is used to allow the subcutaneous delivery conduit to pass through tissue at or near the linear wound and through a wound dressing assembly to a drainage receptacle.

Abstract: In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils.

Abstract: Novel micro-encapsulated topical analgesics are provided to treat pain and may be applied via sleeves having dosed therapeutic sections, especially to joints and extremities. Sleeves may be prepared and packaged inside-out and inverted when positioned by the wearer.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: A sterilized non-discolored eyelid cleansing pad, which has been sterilized by exposure to ?-radiation in a dose level of 2 Mrad.

Abstract: A wound shield to manage repetitive access stress may include a conformable substrate to circumscribe a wound. Any suitable dressing may be secured to the conformable substrate providing separation between the wound and the dressing. The wound substrate may provide a site for attachment of adhesive dressings to shield the patient's skin from the pain of repetitive access and or removal of the dressings. A conformable substrate may be composed of one or more layers of any suitable material and may include adhesive on one or more surfaces to secure the substrate to the wound site and or to secure the dressing to the conformable substrate. A wound substrate may include strong adhesive to secure the substrate to the patients skin. The conformable wound substrate will be formed of any suitable non-absorbent material to permit long term application adjacent a wound. Thus many dressings may be applied and removed from a single wound substrate shielding the patient's skin from repetitive insult.

Abstract: This invention relates to a method of delivering ophthalmic drugs, specifically prostaglandins and prostamides. This method may also be applied to other types of intraocular pressure (IOP)-lowering drugs (e.g. carbonic anhydrase inhibitors, beta blockers, alpha-adrenergic agonists, and parasympathomimetics) as well as other types of ophthalmic drugs for other indications (e.g. dry eye, inflammation, and infection).

Abstract: Embodiments disclosed herein propose the controlled application of a heated spray cloud to a target surface. The spray cloud may be delivered in connection with applications of atomized (misted) sunless tanning sprays using a variety of spray systems. A formulation of the cosmetic or conditioning liquid may conduct and retain heat to allow a pleasantly warm spray to be received on the skin surface. The formula may come to temperature quickly and the heat may be retained even though a nozzle cooling effect inherently cools the spray as it leaves the nozzle.

Abstract: A wound treatment system including a treatment chamber, a source of an aqueous antibiotic, a source of an oxygen-enriched gas, and a control system adapted to alternately surround a human limb with antibiotic mist and the oxygen enriched gas, which can be used to heal lesions such as foot ulcers. A method of treating lesions such as foot ulcers is also disclosed, that includes bathing the lesion in antibiotic mist and contacting it with oxygen gas.

Abstract: Elastomeric articles, such as gloves are disclosed. The gloves include a primary matrix made from one or more elastomeric materials and a foam donning layer. In one embodiment, for instance, the donning layer can be formed from a polyurethane foam. The polyurethane foam can be created from the reaction product of a polyurethane prepolymer and a solution containing water. The resulting foam can be hydrophilic and can absorb moisture for preventing moisture from being trapped between the primary matrix and a user's skin.

Abstract: There is provided methods for administering a toroidal pharmaceutical composition to a subject. The method includes dispensing a toroidal pharmaceutical composition, and allowing the toroidal pharmaceutical composition to contact a target organ of the subject, thereby administering the toroidal pharmaceutical composition. There are additionally provided toroidal aerosol delivery systems.

Abstract: An article of clothing is provided for topically delivering a pharmaceutical composition to a wearer of the article of clothing. The clothing typically includes at least three layers, an optional outer surface layer, a middle layer, and an inner layer. A pharmaceutical composition is applied to the inner layer. The middle layer prevents the pharmaceutical composition from passing from the inner layer to the outer surface layer. A method for delivering a pharmaceutical is also disclosed, wherein a pharmaceutical composition is applied to the inner layer of an article of clothing and the clothing is worn by a person. A pharmaceutical preparation delivery kit is also provided, wherein the kit includes an article of clothing for topically delivering a pharmaceutical composition and a pharmaceutical composition.

Abstract: An apparatus (1) for cleansing wounds (5) in which irrigant fluid from a reservoir connected to a conformable wound dressing (2) and wound exudate from the dressing are moved by a device (18) (which may be a single pump or two pumps) for moving fluid through a flow path (6, 7, 9, 10) which passes through the dressing with a means for providing simultaneous aspiration and irrigation of the wound, and means for supplying thermal energy to the fluid in the wound. The former provides a desired balance of fluid at a controlled nominal flow rate that removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting wound healing over the wound bed. The latter maintains a temperature at the wound bed under the wound dressing at a level that promotes wound healing.

Abstract: An apparatus for stimulating healing of a wound, includes a porous pad adapted to contact a surface of the wound on an affected part of a body. An envelope for receiving the porous pad and the affected part of the body is provided, and the envelope includes a re-sealable opening that permits the wound to be inspected. A connector is fluidly connected to an interior of the envelope and to a source of negative pressure.

Abstract: An eyedrop bottle holder with resilient arms formed from an inverted U-shaped band made from resilient injection molded plastic. The top middle portion of the inverted U-shape band includes a centrally located opening through which the top (dispensing portion) of a standard eyedrop bottle containing eyedrop solution may be positioned and held. The right and left arms of the U-shape band each terminate in an outwardly disposed J-shape foot, the underside of which is covered by a soft rubber-like pad. When a user inserts a standard eyedrop bottle into the holder, the dispensing tip of the eyedrop bottle may be positioned in close proximity to the user's eye. The user may cause his or her eye lid to remain open by using the fingers of one hand to squeeze the right and left arms of the holder together, then placing the pad of one arm on the upper ridge of the orbital eye socket and the pad of the second arm on the lower ridge of the orbital eye socket.

Abstract: Apparatus and methods are provided for the purpose of applying topical treatment on the skin in a standardized and fractionated way. In one aspect of the inventive subject matter, a device includes a trigger activating a pump, which is continuous with a passageway that drains fluid from a reservoir to nozzle. The trigger is operatively coupled to the pump. The pump forces a predetermined volume of fluid to leave the nozzle at a predetermined distance from the skin.

Abstract: A method is provided for making punctal plugs by providing a fibrous strand and extrusion or dip coating the fibrous strand with a polymeric coating and cutting the coated fibrous strand to adequate length for insertion into a mammal body conduit, vessel, cavity, canal, artery, or vein.

Abstract: Apparatus for the provision of topical negative pressure therapy to a user is described, the apparatus comprising a device and a waste canister connected thereto, the waste 5 canister being operably connected for receiving wound exudate to a wound dressing by an aspiration conduit which is releasably connected to the dressing, wherein the waste canister has a blank connector portion thereon for sealably receiving a disconnected dressing end of the aspiration conduit.

Abstract: A synchronized water is disclosed, in which all single water molecules at the same time are arranged in an identical way to a stable homogeneous microstructure, wherein said synchronized water in a distilled condition and at atmospheric pressure has a) a density of from 0.997855 to 0.998836 g/ml at 22° C., b) a water temperature at the freezing point of from ?6.7° C. to ?8.2° C., c) a melting point of from 0.1° C. to 0.2° C., d) a surface tension of from 72.3 to 72.7 dyn/cm at 22 and e) a dielectric constant of from 82.4 to 82.6 F/m, as well as a method for preparation thereof and different uses thereof.

Abstract: A synchronized water is disclosed, in which all single water molecules at the same time are arranged in an identical way to a stable homogeneous microstructure, wherein said synchronized water in a distilled condition and at atmospheric pressure has a) a density of from 0.997855 to 0.998836 g/ml at 22° C., b) a water temperature at the freezing point of from ?6.7° C. to ?8.2° C., c) a melting point of from 0.1° C. to 0.2° C., d) a surface tension of from 72.3 to 72.7 dyn/cm at 22 and e) a dielectric constant of from 82.4 to 82.6 F/m, as well as a method for preparation thereof and different uses thereof.

Abstract: A pharmaceutical composition for induction therapy which has a hypomethylating agent and a histone deacetylase inhibitor (“HDAC inhibitor”); wherein the hypomethylating agent is a DNA and histone methylation inhibitor such as cladribine and the HDAC inhibitor is, for example, entinostat, panobinostat, vorinostat, and/or romedepsin; further wherein the hypomethylating agent and the HDAC inhibitor are combined in formulations for various administrations including e.g., a continuous delivery system such as a transdermal patch of at least one reservoir or a plurality of reservoirs, oral, a fixed-dose oral combination, intravenous, and combinations thereof. This pharmaceutical composition for induction therapy is used with a monoclonal antibody in the treatment of various cancers, sarcomas, and other malignancies.

Abstract: Methods and devices for treatment of skin are disclosed. These methods and devices use electromagnetic radiation to create networks or patterns of treatment zones. The networks or patterns of treatment zones comprise at least four treatment zones, at least two of the treatment zones in the network or pattern are slanted at angles in the skin, and the treatment zones extend at least as deep as the dermal-epidermal junction of the skin. Producing intersecting treatment zones and/or overlapping treatment patterns can increase the effectiveness of the treatments. The devices comprise a hand piece operably coupled to a delivery element, wherein delivery of electromagnetic radiation through the device to a portion of skin produces a network or pattern of treatment zones. The use of these methods and devices results in tightening of the skin and/or improvement in the cosmetic appearance of wrinkles in the portion of skin treated.

Abstract: The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.

Abstract: A method, apparatus, and system are provided for mucous membrane therapy. The method includes receiving at least one body signal from a patient; detecting a condition of the patient based on the body signal; and administering the therapy to at least one of a mucous membrane or a serous membrane of the patient. A medical device system configured to implement the method is provided. A computer-readable storage device for storing instructions that, when executed by a processor, perform the method is also provided.

Abstract: Systems and methods of stimulating or activating fluids for use in wound treatment systems.

Abstract: The present invention concerns a system and device for self-tanning of the type comprising a booth (2) in which two lateral walls (5) have one or more lamps (52) protected by gratings (51) arranged to warm the area inside the booth and to radiate the skin of a person in the booth. The booth is provided with a spraying device (11) for nebulizing a tanning substance. The device comprises a Second control panel (6) connected to a means of management envisaged for activating and governing the diverse functions of the device under the control of an operator or of a user. The system comprises a series of operative phases which envisage, for a person who undergoes a self-tanning session: entering the booth; pressing start on the control panel; the lamps switching on for a preset time and switching off; a tanning solution being sprayed, followed by the lamps being switched on a second time to dry the tanning solution; the lamps being switched off; the person leaving the booth.

Abstract: An emergency eyewash station and dispensing structure therefore is disclosed. The emergency eyewash station includes a main body configured and arranged to hold and dispense eyewash fluid therefrom, an actuator arm assembly movable from a closed position to an open position, and a dispensing structure having an eyepiece sealed by a membrane. The eyepiece is in fluid connection with the eyewash fluid contained in the main body. The dispensing structure is removably coupled to the actuator arm assembly such that when the actuator arm assembly is moved from the closed position to the open position, the membrane is unsealed and the eyewash fluid dispenses from the eyepiece.

Abstract: A preformed wound shield includes a frame formed of one or more layers of suitable material and any suitable covering. Exudate absorbing or transporting material may also be one of two or more layers of material forming the frame.

Abstract: A foaming porous pad suitable for coupling to a hand-held device and for application to human skin includes a porous pad substrate and a foaming composition disposed on the porous pad substrate. The porous pad substrate includes a nonwoven pile fabric having a nonwoven backing layer and a pile comprising individual fibers extending from the backing layer. The nonwoven pile fabric has fibers having a denier of less than about 9. Other aspects of the disclosure include a kit including a foaming porous pad and a motorized handheld device, methods of making the foaming porous pad, and methods of using the foaming porous pad.

Abstract: An apparatus and method for providing cosmetic treatment to skin comprise one material chemically active in a solid form preferably in a tablet form and a second material which is chemically reactive with the first material so that effervescence is produced during the reaction. The chemically active materials may be activated by a user for providing cosmetic treatment to skin. The activation releases effervescence which urges granules of the reacting materials onto the skin. The size of the granules lowers during the reaction thus providing continuously refining peeling to the skin.

Abstract: Methods and apparatus for applying focused pressure to a target vessel to dilate the target vessel for hemodialysis.

Abstract: A method of treating onychomycosis and improving nail appearance for persons suffering onychomycosis, including preparing an aqueous solution containing between 0.3% and 28% (3 g/L or 0.049 mole/L and 280 g/L or 4.53 mole/L) boric acid and between 0.1% and 11% (lg/L or 0.0066 mole/L and 110 g/L or 0.072 mole/L) camphor or other terpene, and applying the solution to the affected nails for a period of time between a few seconds up to 30 minutes at least once per day every day for a sufficiently long period of time for the condition to appreciably improve or to resolve.

Abstract: Various topical compositions for skin care are disclosed. These topical composition include: one or more acidic fermentation products derived from one or more (C1-C6) unsubstituted straight chain alcohols and branched alcohols; one or more alkali metal halides; one or more polysaccharides; and water. Methods of treating acne, seborrheic dermatitis, effects of ageing, blemishes, cleansing and treating skin, and the like, with these various topical compositions are also provided.

Abstract: Described herein are intracameral drug and/or therapeutic bioactive agent delivery devices comprising a substantially cylindrical structure for at least partial placement into the anterior chamber of an eye The intracameral delivery devices have a sustained release material associated with at least a portion of the device and at least one drug and/or therapeutic bioactive agent associated with said sustained release material.

Abstract: The invention relates to a transdermal therapeutic system (TTS) which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system incorporates a back layer and an active substance-containing layer that includes at least one peptide and a carrier substance.

Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.