Abstract: Provided are systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure source provides negative pressure to a wound dressing and positive pressure to an actuator that expels fluid from a fluid reservoir.

Abstract: Apparatus and methods are provided including a patch assembly (20) configured to deliver a substance through a subject's skin. A frame (26) surrounds at least in part an open portion of the patch assembly, such that a region of the skin is exposed through the open portion when the frame is placed on the skin. A substance support area (28) is foldably coupled to the frame at a foldable joint (27). A substance delivery area (23) is adapted to be placed in contact with at least a portion of the region of skin, by the substance support area being folded with respect to the frame. A stiffener (29), disposed on the substance support area between the foldable joint and the substance delivery area, is configured to facilitate the placement of the substance delivery area on the portion of the region of skin. Other applications are also described.

Abstract: A wound treatment system comprises a wound-treatment apparatus and a wound dressing coupled to the apparatus. The wound dressing includes a foam structure wound insert having pores with a greater cross-sectional area when viewed from a first direction and a smaller cross-sectional area when viewed from an orthogonal direction. Methods for making such wound inserts may include compressing foam structure material having pores with a substantially uniform cross-sectional area. Methods for treating a wound using a wound insert.

Abstract: Wound therapy device for the treatment of wounds by means of negative pressure and fluid irrigation, includes a negative-pressure dressing, a pressure sensor which can generate pressure measurement values in order to determine the negative pressure present in the negative-pressure dressing, a drainage container for collecting liquid, and a drainage line by means of which liquid can be conveyed from the negative-pressure dressing into the drainage container. The device can further include a first pump unit for aspirating liquid from the wound space via the drainage line, an instillation container for making available an instillation fluid, an instillation line. Instillation fluid can be delivered from the instillation container into the wound space.

Abstract: This disclosure describes example adhesive medical patches that may be used in combination with one or more antimicrobial agents to create and/or maintain an area of human skin that is free from contaminants. According to some embodiments, the disclosure describes that the adhesive patches may contain an adhesive material affixed to the perimeter of an impermeable backing According to some embodiments, the adhesive patch may also have a permeable layer containing an antimicrobial agent located interior to the adhesive material on the impermeable backing.

Abstract: A method, and apparatus for the controlled acceleration, and/or retardation of the body's inflammatory response generally comprises a foam pad for insertion substantially into a wound site, a heating, a cooling pad for application over the wound site, a wound drape or sealing enclosure of the foam pad, the heating, and cooling pad at wound site The foam pad is placed in fluid communication with a vacuum source for promotion of the controlled acceleration or retardation of the body's inflammatory response. The heating, and cooling provision controls the local metabolic function as part of the inflammatory response.

Abstract: This disclosure describes example antiseptic applicators that may be used in combination with one or more cleansing, antimicrobial and/or antiseptic agents to reduce or eliminate contaminates on a surface. According to some embodiments, the disclosure describes that the applicators may contain an impermeable layer and a permeable layer, where the impermeable layer prevents contaminates for transferring from a user's hand to the permeable layer and the surface.

Abstract: Provided are systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure source provides negative pressure to a wound dressing and a biasing mechanism provides positive pressure to a fluid reservoir.

Abstract: A device for treating at least one infected nail of at least one digit of a subject includes an enclosure sized for housing at least a distal end of at least one digit of a subject having at least one infected nail. The enclosure comprises an integrally molded elastomeric polymer sheath having an interior cavity, which substantially conforms to the size and shape of at least the distal end of the at least one digit of the subject having the at least one infected nail. The sheath has an open end and a closed end, tapering from the closed end to the open end. The elastomeric polymer sheath comprises an elastomeric polymer film having oil resistance and low oxygen permeability. A method of using the device to treat the infected nail is provided. A kit including the device and an antifungal treatment composition is disclosed for treating the infected nail.

Abstract: A portable moist heat delivery system comprising a water vapor generating portion comprising a water vapor source and a heat source; a water vapor-air regulating portion, said water vapor-air regulating portion comprising a water vapor-air mixing layer, and a water vapor-air distribution layer; said water vapor generating portion and said water vapor-air regulating portion being in fluid communication; and said water vapor-air regulating portion having a latent heat delivery surface disposed adjacent said water vapor-air regulating portion which delivers moist heat at a preselected temperature range wherein about 15% to about 95% of the moist heat is latent heat of condensation. Methods include delivering improved pain relief, blood flow, relaxation, and reduced cardiac workload.

Abstract: Embodiments provide a medical device in the form of an applicator for applying a medical composition to a patient. The applicator includes a body, a tip, and a delivery mechanism. The body defines a storage chamber for the medical composition and has an opening for deploying the medical composition from the storage chamber. The tip covers the opening and has a closed state wherein the tip maintains the medical composition in the storage chamber and an open state wherein the medical composition can be deployed through the opening and the tip.

Abstract: A punctal plug or lacrimal insert comprising a microelectromechanical system pump and associated reservoir may be utilized to deliver precise dosages of an active agent into the eye though the tear film. The microelectromechanical system pump comprises four main components; namely, a reservoir, a pump, a series of valves and a vent. The microelectromechanical system pump is positioned within a cavity in the punctal plug. The microelectromechanical system pump is positioned with a cavity in the punctal plug.

Abstract: Dry eye treatment apparatus and methods are described herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more patches. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomiam glands contained within the underlying region of skin.

Abstract: Described herein is an automated fluid drain control apparatus and method which comprises a first collection chamber which is connected to a drain that has been inserted into the subarachnoid area in lumbar region of the body. The volume of fluid into the first collection chamber is controlled as a function of time by being constantly measured such that too much fluid will not be drained from the body.

Abstract: The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.

Abstract: A device for delivering an active agent to a tissue (100), comprising; a housing (10) including a reservoir (20) for containing said active agent; a delivery tip (35) being in fluid communication with said reservoir; and, a delivery mechanism (40) capable of delivering a predetermined amount of said active agent and releasing the same upon contact between said delivery tip and said tissue.

Abstract: A preparation for the transdermal delivery of a biologically active substance into the body of a patient comprises particles of a formulation comprising the active substance. The particles are irregular in size and shape and may be produced by a low cost manufacturing method such as grinding from a thin film. The particles are angular, i.e. they have sharp edges and corners that allow them to penetrate the outer layer of the skin when subjected to pressure from a roller or an array of blunt-tipped microstructures. Sucrose may be used as an excipient with the active substance to form suitably rigid and angular particles.

Abstract: Devices having selectively permeable barriers are provided with a substrate, a first layer overlaying at least a portion of the substrate, and a second layer overlaying at least a portion of the first layer. The first layer has at least one first pore and the second layer has at least one second pore. At least a portion of the first and/or second layers are movable with respect to each other between an open condition and a closed condition in response to a change in an environmental factor. In the open condition, the first and second pores are substantially aligned to allow fluid communication between the substrate and the outside environment. In the closed condition, the first and second pores are substantially misaligned to prevent fluid communication between the substrate and the outside environment.

Abstract: A device for scar management includes an applicator head including a recess having a rotating means therein, a reservoir containing a silicone composition fluidly connected to the applicator head, and a metering valve fluidly connected to the reservoir. A metered dose of the silicone composition is delivered from the reservoir to the applicator head upon the application of external pressure to the metering valve. The invention also relates to a method for scar management using such device by identifying a target skin area having a wound or scar, contacting the outward surface of the applicator head to the target skin area, massaging the rotating means of the applicator head on the target skin area, and applying the silicone composition to the target skin area via the rotating means.

Abstract: This disclosure describes example antimicrobial compositions that may be used in combination with IV port cleansing caps, protective caps, or both. According to another implementations, the disclosure describes various cap devices that may be used in combination with the antimicrobial composition to cleanse, sanitized, and/or disinfected a surface.

Abstract: A method of wound treatment can comprise providing a wound treatment device with a wound surface cover and a wound insert. The method can also include positioning the wound insert in contact with the wound, covering the wound insert and wound with the wound surface cover, affixing the wound surface cover to the skin surrounding the wound and compressing the wound insert by applying pressure to the wound surface cover.

Abstract: A method for delivering a local anesthetic to a body part includes applying the local anesthetic to an inner portion of a disposable undergarment having a corrugated region in front of the disposable undergarment, wherein the local anesthetic fills at least one pocket of the corrugated region. The method includes covering the body part with the disposable undergarment such that the local anesthetic is subsequently released from the corrugated region and is absorbed percutaneously into the body part to allow numbing of the body part.

Abstract: Wound treatment dressings comprising combinations of at least one conductive layer, at least one absorbent layer or a moisture regulation layer, and methods of making and methods of use are disclosed for treatment of wounds in humans and animals. The novel dressings aid in healing by helping restore the transepithelial potential of the skin, providing a functional anti-microbial barrier, and allowing for regulation of the moisture content of the wound without disturbing the wound.

Abstract: An apparatus and method for dispersing fluid from a fluid dispersal line is provided. The method comprises initiating operation of the medical apparatus, determining whether fluid has been dispersed from the medical apparatus via the fluid dispersal line since said initiating occurred, and assessing whether fluid is available in the fluid dispersal line. If fluid has not been dispersed from the medical apparatus since said initiating occurred and fluid is not available in the fluid dispersal line, the method includes distributing a commanded quantity of fluid plus an amount of fluid determined to fill the fluid dispersal line. Otherwise the method disperses only the commanded quantity of fluid.

Abstract: The composite wound dressing apparatus promotes healing of a wound via the use of a vacuum pump. The vacuum pump applies a vacuum pressure to the wound to effectively draw wound fluid or exudate away from the wound bed. The vacuum pump is tethered to the wound dressing and is portable, preferably, carried by the patient in a support bag, which permits patient mobility. Moreover, the patient does not need to be constrained for any period of time while exudate is being removed from the wound.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.

Abstract: Disclosed herein are devices, systems and methods for using such devices and systems for treating incisions and wounds. In an aspect, disclosed is a device having a generally planar tension relief module and a flexible sealant structure sized to cover the tension relief module, the flexible sealant structure comprising a lower adhesive surface. The tension relief module includes a conduit structure having a plurality of support structures on an upper surface of the conduit structure and at least one opening extending through the conduit structure from a lower surface to the upper surface. At least a portion of the conduit structure is adapted to be aligned with a longitudinal axis of the incision. The tension relief module also includes opposing adhesive structures coupled to the conduit structure. The lower adhesive surface of the flexible sealant structure and the upper surface of the conduit structure form a flow pathway.

Abstract: A therapeutic device includes a fluid mover for one of raising, compressing, or transferring fluid, a therapeutic member operably connected to the fluid mover and actuated thereby, the therapeutic member operably disposably used on a patient in a manner to deliver therapy to the patient as function of actuation of the fluid mover, a controller operably associated with the fluid mover for controlling operation thereof, and a leak, blockage, temperature, voltage or current sensor operably connected to the fluid mover and the controller and to sense a leak, blockage, temperature, voltage or current in the device and send a signal to the controller whereby the controller controls the fluid mover as a function of the sensed signal.

Abstract: A medical skin applicator apparatus includes a fluid housing having a fluid chamber for storing a medical agent and an applicator coupled to the housing. The fluid housing has a penetrable wall to permit access to the fluid chamber and release of the medical agent therefrom. The applicator includes an applicator surface for applying the medical agent to a patient. The applicator has a penetrating member adapted to penetrate the penetrable wall of the fluid housing upon achieving a predetermined coupled relation of the fluid housing and the applicator, to thereby permit the medical agent to be dispensed from the fluid chamber and applied to the patient with the applicator surface.

Abstract: The invention relates to a self-destructing transdermal therapeutic system (TTS), preferably in the form of a transdermal patch, that includes an active ingredient, an agent rendering the active ingredient useless, and a perforation mechanism. The perforation mechanism allows a mobile phase to reach an agent that is capable of rendering the active ingredient useless after removing the TTS after use. The agent then comes into contact with the active ingredient and destroys the active ingredient in the presence of the mobile phase.

Abstract: A reduced pressure delivery system is provided and includes a primary manifold, a blockage prevention member, and first and second conduits in fluid communication with the primary manifold. The primary manifold includes a wall surrounding a primary flow passage and is adapted to be placed in proximity to a tissue site. The blockage prevention member is positioned within the primary flow passage. A plurality of apertures is disposed in the wall to communicate with the primary flow passage. The first conduit is fluidly connected to the primary flow passage to deliver reduced pressure through the primary flow passage and the plurality of apertures. The second conduit includes an outlet proximate the primary flow passage or an outlet of the first conduit to purge the primary flow passage or first conduit to prevent blockages.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A neurosurgical sponge apparatus and related methods are disclosed. The neurosurgical sponge apparatus has a first layer formed from a fluid absorbent material. A second layer is affixed to the first layer, wherein the second layer is formed from a water-soluble material.

Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) a terpenoid.

Abstract: A convenient and hygienic skin therapy system comprising an encaser, one or more therapeutic compositions, a sealing means and optional accessories is disclosed. A method of using such a skin therapy system is also provided. The skin therapy system and the use thereof provides an effective, efficient and safe therapeutic approach.

Abstract: A method of treating a wound by restoring a bodies' physiological norms is disclosed. A wound dressing is applied over the wound in which the wound dressing has an inlet and an outlet and furthermore forms a substantially airtight cover over the wound. A vapor is supplied to the wound dressing via the inlet. The wound is warmed by condensing the vapor into a condensate on a surface of the wound, thereby releasing a latent heat of vaporization and adding moisture to the wound. The excess condensate is removed from the wound dressing via the outlet.

Abstract: A pressure bandage includes a banding porting, at least one infiltration and at least one fixing member. The banding portion includes at least one recession formed in one side of the banding portion, at least one tube having first and second ends, and at least one check valve mounted in the second end of the tube. The first end of the tube is connected to the recession. The infiltration is coupled on the inner surface of the recession of the banding portion. The fixing member fixes the banding portion to a treatment part.

Abstract: This invention provides for a method and a device for dispensing precise quantities of a predetermined volume of medicaments or other liquids onto the eye, via one or more discrete drop(s) generated by the device in a practical and innoxious way to users.

Abstract: This invention provides for a method and an EMDU used to dispense precise quantities of liquids with an image sensor being capable of providing feedback to the user as to both, when an eye is properly aligned with the EMDU, and to detect and track the quantity of the dose administered on to the eye.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: A method of providing a skin benefit to the skin including the use of a skin care active and a portable moist heat delivery system comprising: a water vapor generating portion comprising a water vapor source and a heat source; and a water vapor-air regulating portion located at a skin-facing side of the water vapor generating portion, the water vapor-air regulating portion comprising a water vapor-air mixing layer, a water vapor-air distribution layer, a latent heat delivery surface, and optionally a skin contact layer, where the water vapor generating portion and the water vapor-air regulating portion are in fluid communication is disclosed.

Abstract: An apparatus for controlling vacuum pressure is provided. The apparatus includes a multiple axis controller, such as a dual axis footpedal, and a processing apparatus, such as an instrument host running software, configured to receive multiple axis data from the multiple axis controller. The apparatus also includes a first pump configured to provide nonzero fluid pressure at a first nonzero fluid pressure level based on a first axis state of the multiple axis controller and a second pump configured to provide nonzero fluid pressure at a second nonzero fluid pressure level based on a second axis state of the multiple axis controller. The processing apparatus causes switching between the first pump and the second pump based on the first axis state and the second axis state of the multiple axis controller.

Abstract: Disclosed are devices which generate a mist of a treatment composition, viz, an aerosolized treatment composition which imparts a technical benefit to surfaces, or airspaces, which come into contact with the said aerosolized treatment composition. Also disclosed are methods for the treatment of surfaces utilizing the devices of the invention.

Abstract: The present invention is about a transdermal method that deliveries nutrients from fresh animal organs to the systemic circulation of the human body by applying the juice or chopped pieces of the fresh animal organs on the skin of the human body and allowing the nutrients to absorb through the layers of the exposed skin. The present invention aims to preserve the Yin and Yang energies naturally present in fresh organs and other foods that are lost in cooking and processing of foods. The present invention uses the full skin area transdermal delivery method by soaking the whole body in the juice of the fresh animal organs as well as the partial skin area transdermal delivery method by exposing certain parts of the human skin area to the fresh juices or chopped fresh animal organs and allowing the nutrients to enter the systemic circulation of the human body.

Abstract: Disclosed are devices which generate a mist of a treatment composition, viz, an aerosolized treatment composition which imparts a technical benefit to surfaces, or airspaces, which come into contact with the said aerosolized treatment composition. Also disclosed are methods for the treatment of surfaces utilizing the devices of the invention.

Abstract: An apparatus for applying cosmetic or treatment material to a user's lips includes a container containing a lip cosmetic product or a lip treatment product in solid or semi-solid form. An applicator is mounted on the container, the applicator having an upper surface formed in the general shape of human upper and lower lips. In one embodiment, the applicator has apertures extending through the applicator. The apertures advance the product in the container through the apertures and onto the upper surface of the applicator when the container is manipulated. A user applies their lips to the upper surface of the applicator, transferring the product to the user's lips. In a further embodiment, the lip product in the container and the applicator are one solid or semi-solid structure, with the upper surface of the structure formed generally in the shape of a pair of human lips.

Abstract: A unitary biodegradable, absorbent flexible back and body strap for selectively applying a protective substance and a skin-protective agent to a user's body, the strap having an elongated thin parallelepiped midportion, a biconcave first gripping end, and an opposite biconcave second gripping end, each end having a tip narrower in width than the midportion. The midportion is impregnated with a protective substance, which may be a body lotion, sunscreen, insect repellant, or a combination of sunscreen and insect repellant. At least one protective agent layer may be disposed on a midportion top side, which contains a skin-protective agent. The user alternatingly pulls the first gripping end and the second end from side to side across the desired body portion to selectively apply the protective substance and the skin-protective agent discards the strap whereinafter the strap biodegrades.

Abstract: A device used for applying an antiseptic preparation to a surgical site of a patient prior to surgery outside of an operating theater. A loose-fitting bag is provided which encloses the surgical site by securing the open end(s) to the patient by closing means. A method and apparatus are also provided for releasing antiseptic into the interior of the bag. The method provides that the surgical site can be scrubbed within the bag so as to properly prepare the skin for surgery. A temperature indicator for the antiseptic preparation is also provided.

Abstract: Disclosed are devices, systems and methods for treating an incision. The device includes a generally planar tension relief module, comprising a central structure in fluid communication with the incision, wherein at least a portion of the central structure is adapted to be aligned with a longitudinal axis of the incision; and opposing adhesive structures coupled to the central structure and a flexible sealant structure comprising a lower adhesive surface and sized to seal over the tension relief module forming a sealed flow pathway. The opposing adhesive structures are adapted to be stretched from a relaxed configuration to a first tensile configuration and to return towards the relaxed configuration from the first tensile configuration into a second tensile configuration and impart a contracting force in a direction that is towards the opposing adhesive structure.