Abstract: Under one aspect, an apparatus includes a primary dressing configured for application over a region of compromised skin and including fluid-absorbing material; and a secondary dressing configured for application over the primary dressing. The secondary dressing applies pressure to the primary dressing so as to maintain the primary dressing in place over the region of compromised skin and promote the flow of fluid from the region of compromised skin into the fluid-absorbing material, and allows moisture in the fluid to evaporate from the fluid-absorbing material. Under another aspect, a dressing includes a fabric layer sized to cover a region of compromised skin; a foam layer secured to the fabric layer and having an aperture defined therein sized to cover the region of compromised skin; and a biocompatible adhesive layer disposed on the foam layer. Methods of applying the dressing also are provided.

Abstract: An ostomy device that comprises an adhesive wafer for attaching to the skin around the stoma. The wafer comprises an adhesive layer having a proximal adhesive side and a distal side, where the distal side is covered with a backing layer. The wafer comprises a central portion and a peripheral portion, and it comprises a proximal section located on the proximal side of the central portion and a distal section visually arranged on the distal side of peripheral portion, wherein the distal section changes colour when the proximal section is exposed to fluid.

Abstract: A system for providing reduced-pressure treatment to a tissue site of a patient includes a reduced-pressure source for supplying reduced pressure, a fluid source for supplying a fluid, and a plurality of inflatable bladders for placing adjacent the tissue site. The inflatable bladders are operable to receive the fluid to expand from an uninflated position to an inflated position. The system also includes a plurality of chambers that are compressible. At least one of the plurality of chambers is disposed between a first inflatable bladder and a second inflatable bladder of the plurality of inflatable bladders.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: Pharmaceutical compositions of a H2 receptor antagonist and ibuprofen are provided herein. The compositions comprise, e.g., a core and a shell separated by a barrier layer, bilayered or trilayered compositions, or liquid formulations. Also provided are methods of making the pharmaceutical compositions, and methods of treatment comprising administering the pharmaceutical compositions.

Abstract: Maggot debridement therapy dressing embodiments and methods are discussed for the treatment of a variety of indications including wound care, including septic wound care and the like.

Abstract: The present invention relates to a wound dressing and in particular a wound dressing for application to the sacrum of a patient. The wound dressing is an absorbent pad having one or more lines about which the dressing can fold.

Abstract: Transdermal compositions are provided. Aspects of the transdermal compositions include: an active agent layer and a conversion layer, where the conversion layer includes a weak base and, optionally, a carboxylated component. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.

Abstract: The present invention relates to a method and dressing for detecting detachment of the dressing, which is applied to a surface of an at least partly electrically conductive object. The dressing comprises an adhesive for attaching the dressing to the electrically conductive object and at least two electrodes arranged in a distance from the electrically conductive object. A voltage is applied to the first and second electrode establishing an electrical circuit comprising a first capacitor between the first electrode and the electrically conductive object and a second capacitor between the second electrode and the electrically conductive object. Changes of the capacitance between at least one of the first and the second electrode and the electrically conductive object are detected, and an alarm is activated when the changes of the capacitance reach a predetermined value. This advantageously provides a method whereby a leak can be detected quickly.

Abstract: An adhesive patch configured to attach an ostomy appliance to a patient includes a peripheral rim disposed around a central hole that is attachable to a stoma of the patient; and a band of adhesive extending from the peripheral rim to an inner border of the adhesive patch and having a pattern of curvilinear indentations extending to the peripheral rim of the patch.

Abstract: Disclosed are devices, systems and methods for treating an incision. The device includes a generally planar tension relief module, comprising a central structure in fluid communication with the incision, wherein at least a portion of the central structure is adapted to be aligned with a longitudinal axis of the incision; and opposing adhesive structures coupled to the central structure and a flexible sealant structure comprising a lower adhesive surface and sized to seal over the tension relief module forming a sealed flow pathway. The opposing adhesive structures are adapted to be stretched from a relaxed configuration to a first tensile configuration and to return towards the relaxed configuration from the first tensile configuration into a second tensile configuration and impart a contracting force in a direction that is towards the opposing adhesive structure.

Abstract: Pump cassettes, wound-treatment apparatuses and methods. In some embodiments, a pump cassette comprises: a pump body having a pump chamber, an inlet valve in fluid communication with the pump chamber, and an outlet valve in fluid communication with the pump chamber; a diaphragm coupled to the pump body such that the diaphragm is movable to vary a volume in the pump chamber; and an identifier configured to store one or more properties of the pump cassette such that the identifier is readable by an automated reader to determine the one or more properties. In some embodiments, the pump cassette is configured to be removably coupled to a wound-treatment apparatus having an actuator such that the actuator can be activated to move the diaphragm.

Abstract: The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein the product comprises at least one further antibacterial compound; a delivery system comprising a container connected to a means of delivery which is connected to a pad, wherein said container comprises a composition comprising acetic acid and said pad comprises a self-adhesive material; a kit comprising a dressing and an adhesive membrane, wherein the dressing comprises a composition comprising acetic acid; a method of treating a wound comprising a) applying acetic acid to the wound and b) applying a negative pressure to the wound.

Abstract: Provided is a device for treatment of wounds using reduced pressure, which includes a pump, a gas barrier cover, a first compressible material which expands after compression, and a second material capable of absorbing wound fluids several times its own weight. The first and second materials are arranged inside the cover and form a reservoir connected to the pump. The device also includes an inlet for connecting the reservoir with a wound, a wound pad to be arranged in the wound cavity, and a sealing covering the wound and the wound pad. A third material with high liquid spreading capability is arranged around at least a major part of the first material, and the second material is in the form of at least one layer arranged outside the third material and separated from the first material by the third material.

Abstract: An emergency medication storage and integrated single use device for providing oral dissolving medications strips in a convenient transparent transfer environment. A thin card size dispenser holds a single medicated strip in user access orientation positioned for direct card insertion to the user's mouth assuring proper dispensing of the medication in an emergency situation.

Abstract: A low-profile reduced pressure treatment apparatus and system are provided. The apparatus includes a moldable conduit holder, a conduit through the conduit holder, and a flexible base. The conduit holder has first and second bulkhead surfaces, a convex top surface, and a bottom surface adapted to conform to a tissue contact region adjacent to a tissue site. An end of the conduit is substantially flush with the first bulkhead surface and a longitudinal axis of the conduit is substantially perpendicular to the first and second bulkhead surfaces. The base is connected on a first side to the bottom surface of the conduit holder, and extends beyond the first bulkhead surface to form an overlay zone adjacent the first bulkhead surface. An adhesive is disposed on a second side of the flexible base to secure the flexible base to the tissue contact region.

Abstract: To provide a wound dressing having absorbability and improved so as not to be adhere to wounds, a wound dressing 10 is provided, which includes a perforated material 20 having a top face and a bottom face and having plural through-holes 21, and an absorbent material 30 disposed on the top face of the perforated material, and in which at least the bottom face of the perforated material 20 is coated with a silicone resin 40 except leaving at least a part of the through-holes so as not to block up all the through-holes, and at least a part 31 of the absorbent material facing the through-holes of the perforated material is coated with the silicone resin 40, and to allow fluid penetration from the bottom face side of the perforated material into the inside of the absorbent material.

Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining blood clotting material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attachable to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate blood clotting material is in direct contact with blood. The mesh may include a zeolite powder impregnated or otherwise incorporated therein.

Abstract: A tissue oxygenation device for creating and oxygen gradient that promotes the diffusion of oxygen from underlying capillaries and subcutaneous tissue up through and over an overlying target site of skin tissue, comprising: a gas impermeable encasement which forms a chamber which surrounds the target site when the encasement is positioned over the target site; an oxygen scavenging member comprising an oxygen scavenger, wherein the oxygen scavenging member is contained within the chamber such that the oxygen scavenger is exposed to oxygen within the chamber, and further wherein the oxygen scavenger removes oxygen contained within the chamber at a continuous rate; and an adjustable cuff, wherein the adjustable cuff comprises a pliable body which is attached to the gas impermeable encasement on an end of the body and to the target site at another end of the body; wherein the gas impermeable encasement and the adjustable cuff jointly operate to seal the target site within the chamber.

Abstract: Medical dressings and medical dressing kits that can be used to provide a ported medical dressing for placement over a wound or other body site where controlled fluid access is desired. The controlled fluid access provided by the medical dressings may be useful to remove fluids from the wound (as in, e.g., negative or reduced pressure therapies), to provide one or more gases to a wound site, to provide one or more liquids to a wound site, and/or to provide one or more active agents to a wound site. To achieve controlled fluid access, the medical dressing and medical dressing kits may include a port body with a lower surface that is adhesively adhered to the skin at the periphery of a wound or other body site.

Abstract: A pad is provided that supplies light to a composite layer, which may be provided on a wound. The composite layer may include a combination including a form of collagen and a chromophore that releases a reactive oxygen species upon exposure to the light. The reactive oxygen species may then act to kill bacteria or other microorganisms in the wound.

Abstract: Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Abstract: A reduced-pressure system for delivering reduced pressure for medical purposes to a desired site and to receive fluids in one instance includes a reservoir having an interior space operable to contain the fluids. A reduced-pressure delivery conduit is placed in fluid communication with the interior space for delivering the reduced pressure to the desired site. A source conduit and a pressure sensor conduit are placed in fluid communication with the interior space. A pressure sensor is placed in fluid communication with the pressure sensor conduit. A reduced-pressure source is placed in fluid communication with the source conduit. A reduced-pressure control unit is associated with the pressure sensor and the reduced-pressure source and is operable to receive pressure data from the pressure sensor and supply data from the reduced-pressure source and to determine when a reservoir-full/blockage condition exists. Other systems and methods are presented.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: A sterilized non-discolored eyelid cleansing pad, which has been sterilized by exposure to ?-radiation in a dose level of 2 Mrad.

Abstract: A flexible pneumostoma management device maintains the patency of a pneumostoma while controlling the flow of material through the pneumostoma. The pneumostoma management device includes a pneumostoma vent having a tube which enters the pneumostoma to allow gases to escape the lung, a flange and a filter/valve to control flow of materials through the tube. The flange is a thin flexible patch comprises of multiple thin layers of materials and which conforms and attaches to the chest of the patient. The flange includes a filter, a protective outer layer and an inner hydrocolloid layer. The flange secures the tube in position in the pneumostoma.

Abstract: A wound shield to manage repetitive access stress may include a conformable substrate to circumscribe a wound. Any suitable dressing may be secured to the conformable substrate providing separation between the wound and the dressing. The wound substrate may provide a site for attachment of adhesive dressings to shield the patient's skin from the pain of repetitive access and or removal of the dressings. A conformable substrate may be composed of one or more layers of any suitable material and may include adhesive on one or more surfaces to secure the substrate to the wound site and or to secure the dressing to the conformable substrate. A wound substrate may include strong adhesive to secure the substrate to the patients skin. The conformable wound substrate will be formed of any suitable non-absorbent material to permit long term application adjacent a wound. Thus many dressings may be applied and removed from a single wound substrate shielding the patient's skin from repetitive insult.

Abstract: Skin rejuvenation system and method in which a pure plant collagen carrier is saturated with a solution of collagen, allantoin, amino acid, propanediol, glycerin, algae, plant DNA living cells, epidermal growth factor, Vitamin E, hyaluronic acid, rose essential, water, and peptide, and the saturated carrier is applied to the skin to be rejuvenated.

Abstract: Disclosed is an apparatus for the treatment of a wound on a patient. The apparatus is capable of administering localized negative pressure therapy to the wound using a hospital wall vacuum source and a drain line for removing exudate from the wound. The apparatus may also be capable of administering localized hyperbaric oxygen therapy to the wound using a hospital wall oxygen source and a supply line for supplying oxygen to the wound. The apparatus includes at least one regulator to control the application of negative pressure therapy and hyperbaric oxygen therapy.

Abstract: An anal patch comprising an absorbent pad (3) in a shape with two substantially parallel flat surfaces and a contact surface perpendicular to the flat surfaces, the area of the contact surface being smaller than each of the two parallel flat surfaces, an adhesive part, comprising an adhesive coated backing layer (4), having a central aperture (8) wherein at least a part of the contact surface of the absorbent pad is aligned with the aperture of the adhesive part.

Abstract: An article of clothing is provided for topically delivering a pharmaceutical composition to a wearer of the article of clothing. The clothing typically includes at least three layers, an optional outer surface layer, a middle layer, and an inner layer. A pharmaceutical composition is applied to the inner layer. The middle layer prevents the pharmaceutical composition from passing from the inner layer to the outer surface layer. A method for delivering a pharmaceutical is also disclosed, wherein a pharmaceutical composition is applied to the inner layer of an article of clothing and the clothing is worn by a person. A pharmaceutical preparation delivery kit is also provided, wherein the kit includes an article of clothing for topically delivering a pharmaceutical composition and a pharmaceutical composition.

Abstract: A flexible pneumostoma management device maintains the patency of a pneumostoma while controlling the flow of material through the pneumostoma. The pneumostoma management device includes a pneumostoma vent having a tube which enters the pneumostoma to allow gases to escape the lung, a flange and a filter/valve to control flow of materials through the tube. The flange is a thin flexible patch which conforms and attaches to the chest of the patient. The flange secures the tube in position in the pneumostoma. The device has features to control secretions from the pneumostoma. The secretion management features include, ridges, pores, absorbent materials, and combinations thereof.

Abstract: A vacuum bandage is provided for use with a wound having a wound surface. The bandage is connectable to a vacuum source and includes a wound dressing member having a wound contacting surface, a top surface, and a port configured for communication with the vacuum source. The wound dressing member further includes holes in the wound contacting surface configured for communication with the wound surface of the wound and a passageway between the port and each hole. The vacuum bandage further includes a pack adjacent to the top surface of the member. The pack may include an aperture positioned about the port.

Abstract: An apparatus (1) for cleansing wounds (5) in which irrigant fluid from a reservoir connected to a conformable wound dressing (2) and wound exudate from the dressing are moved by a device (18) (which may be a single pump or two pumps) for moving fluid through a flow path (6, 7, 9, 10) which passes through the dressing with a means for providing simultaneous aspiration and irrigation of the wound, and means for supplying thermal energy to the fluid in the wound. The former provides a desired balance of fluid at a controlled nominal flow rate that removes materials deleterious to wound healing, while distributing materials that are beneficial in promoting wound healing over the wound bed. The latter maintains a temperature at the wound bed under the wound dressing at a level that promotes wound healing.

Abstract: A pneumostoma management device for maintaining the patency of a pneumostoma while controlling the flow of gases and discharge through the pneumostoma. The pneumostoma management device includes a bulb connected to a tube which enters the pneumostoma. A flow control device regulates air flow in and out of the pneumostoma via the tube. A hydrophobic filter traps discharge in the bulb while allowing gases to escape.

Abstract: A medical dressing for an open wound includes a base, and a raised flexible therapeutic cover formed with base. The base has opposing inside and outside major surfaces, and continuous inside and outside peripheral edges. The inside peripheral edge defines a wound site opening and designed to surround the open wound. The raised-flexible therapeutic cover extends over and above the wound site opening defined by the inside peripheral edge. A compression spring resiliently spaces the therapeutic cover from the open wound.

Abstract: The present invention provides systems and methods for protecting a wound and managing exudate released from the wound comprising a dressing having a support cushion for surrounding the wound and periwound region; a wicking strip for application in the periwound region between the support cushion and the wound; and a reservoir for application over the wicking strip, the wicking strip configured to transfer exudate from the wound to the reservoir, where the exudate is sequestered. Various alternative embodiments are described in which the wicking strip may be custom-fit to approximate an irregular wound margin, to apply a preferred pressure gradient to the periwound regions, to periodically apply fluids to the wound bed or to apply negative pressure wound therapy. Methods of applying the dressing also are provided.

Abstract: Apparatus for the provision of topical negative pressure therapy to a user is described, the apparatus comprising a device and a waste canister connected thereto, the waste 5 canister being operably connected for receiving wound exudate to a wound dressing by an aspiration conduit which is releasably connected to the dressing, wherein the waste canister has a blank connector portion thereon for sealably receiving a disconnected dressing end of the aspiration conduit.

Abstract: This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.

Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.

Abstract: The invention relates to a device for the negative pressure treatment of wounds comprising (a) a covering material for providing a wound area with an air-tight seal; (b) optionally means for connecting a negative pressure source; and (c) a wound dressing containing (c1) an open-celled foamed material which is wetted with (c2) an ointment base and (c3) a swelling material, and also a process for producing a corresponding wound dressing. In addition, the invention relates to the use of an open-celled foamed material, which is wetted with an ointment base, for application as a wound dressing in the negative pressure treatment of wounds.

Abstract: The invention relates to a device for the negative pressure treatment of wounds comprising (a) a covering material for providing a wound space with an air-tight seal; (b) optionally means for connecting a negative pressure source; and (c) a wound dressing containing (c1) a nonwoven material which is wetted with (c2) an ointment base, and also a method for producing a corresponding wound dressing. In addition, the invention relates to the use of an nonwoven material, which is wetted with an ointment base, for application as a wound dressing in the negative pressure treatment of wounds.

Abstract: A pharmaceutical composition for induction therapy which has a hypomethylating agent and a histone deacetylase inhibitor (“HDAC inhibitor”); wherein the hypomethylating agent is a DNA and histone methylation inhibitor such as cladribine and the HDAC inhibitor is, for example, entinostat, panobinostat, vorinostat, and/or romedepsin; further wherein the hypomethylating agent and the HDAC inhibitor are combined in formulations for various administrations including e.g., a continuous delivery system such as a transdermal patch of at least one reservoir or a plurality of reservoirs, oral, a fixed-dose oral combination, intravenous, and combinations thereof. This pharmaceutical composition for induction therapy is used with a monoclonal antibody in the treatment of various cancers, sarcomas, and other malignancies.

Abstract: The present disclosure relates to dressings, such as adhesive bandage, which can have an absorbent pad, and non-stick film secured thereto which has at least two different polymeric materials, a first polymeric material and a second polymeric material having a lower melting point than the first polymeric material.

Abstract: Systems and methods of stimulating or activating fluids for use in wound treatment systems.

Abstract: A skin patch for absorbing toxins from a body includes a first side having a heat reflective foil. A second side includes a non-woven rayon surface for absorbing the toxins. The rayon surface includes a plurality of openings for enhancing far infrared ray emission into a skin when the second side is placed in contact with the skin. A mixture of natural ingredients includes vinegar, chitosan, loquat leaf, houttuynia cordata, vitamin C, tourmaline, vegetable fiber, and dextrin. The mixture is formulated to emit the far infrared emission, whereby blood circulation is promoted and perspiration and any toxins contained therein are absorbed by the rayon surface.

Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.

Abstract: An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.

Abstract: An apparatus for fluid collection is disclosed, which comprises: a frame, composed of a plurality of unit cells, each being made of an absorbent polymer composite; and a bag, for receiving the frame while being connected to a conduit provided for enabling a fluid to flow in and out the bag therethrough.

Abstract: A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.