Abstract: The present invention relates to a percutaneous absorption preparation comprising an anti-dementia drug, which is lower skin irritation. More specifically, the present invention relates to a percutaneous absorption preparation comprising a drug-containing layer comprising an anti-dementia drug, a polymer compound having an amino group, a polyhydric alcohol fatty acid ester, a polyhydric alcohol, a polyvalent carboxylate ester, and a styrenic polymer compound, wherein the content of the anti-dementia drug is 0.5-20 mass % of the drug-containing layer.

Abstract: A reduced pressure treatment appliance is provided for treating a wound on the body of a patient. In some embodiments, the appliance comprises a cover, which can have a top cup member and an interface member. The interface member can have flow control means, configured to permit exudate from the wound to flow through the flow control means into the volume under the cover, but not in the opposite direction. Also, in some embodiments, the top cup member can have a lid member, a cup body member, and lid attachment means to removably attach the lid member to the cup body member. In some embodiments, the cover can be configured to facilitate access to the wound for monitoring, treatment and other purposes without removing the cover from the body. The wound treatment appliance can have a vacuum system to supply reduced pressure to the site of the wound in the volume under the cover. A suction bulb can be used to provide a source of reduced pressure to the cover.

Abstract: A manipulation tool is disclosed for producing cell material having multiple biological cells, which have a predefined geometrical arrangement. The tool includes a tool body, whose surface at least partially contacts the cell material, and a setting device for adjusting the tool body by a continuous expansion, so that geometrical properties of the surface change and an interior of the tool body is enlarged. The setting device is adapted to expand the tool body at an advance velocity in a range from 0.1 ?m/h to 1 mm/h.

Abstract: A wound dressing comprises a wound-contacting layer composed of a mixture of honey and a moisture-absorbing agent; a water-permeable fabric backing layer; and an intermediate layer comprising water-permeable fabric impregnated with a mixture of honey and a moisture-absorbing agent.

Abstract: A composition suitable for use in a transdermal delivery patch for administration of an opioid, the composition comprising a phosphate compound of tocopherol and a polymer carrier.

Abstract: A pressure bandage includes a banding portion having opposite first and second sides. A chamber is formed in the first side of the banding portion. The second side of the banding portion includes a hole in communication with the chamber. A bladder is received in the chamber and receives a fluid. The bladder includes an infiltratable surface permeable to the fluid. The infiltratable surface of the bladder and the first side of the banding portion face the same direction. The fluid received in the bladder is permeable out of the bladder via the infiltratable surface. A control member is engaged with the hole of the banding portion and imparts a pressure to the bladder. The hole can be a screw hole, and the control member includes a knob threadedly engaged with the screw hole such that the knob is rotatable to adjust the pressure imparted to the bladder.

Abstract: A non-invasive tissue oxygenation system for accelerating the healing of damaged tissue and to promote tissue viability is disclosed herein. The system is comprised of a lightweight portable electrochemical oxygen concentrator, a power management system, microprocessors, memory, a pressure sensing system, a temperature monitoring system, oxygen flow rate monitoring and control system, a display screen and key pad navigation controls as a means of providing continuous variably controlled low dosages of oxygen to a wound site and monitoring the healing process. A kink resistant oxygen delivery tubing, whereby the proximal end is removably connected to the device and the distal end with holes or a flexible, flat, oxygen-permeable tape is positioned on the wound bed as a means of applying oxygen to the wound site. The distal end of the tube is in communication with the electrochemical oxygen concentrator and wound monitoring system to communicate temperature and oxygen partial pressure information.

Abstract: Provided are devices, compositions and methods utilizing EP4 and EP2 receptor agonists for preventing, reducing, or treating capsular contracture occurring in response to the implantation of breast prostheses.

Abstract: A reduced pressure treatment appliance is provided for treating a wound on the body of a patient. In some embodiments, the appliance comprises a cover, which can have a top cup member and an interface member. The interface member can have flow control means, configured to permit exudate from the wound to flow through the flow control means into the volume under the cover, but not in the opposite direction. Also, in some embodiments, the top cup member can have a lid member, a cup body member, and lid attachment means to removably attach the lid member to the cup body member. In some embodiments, the cover can be configured to facilitate access to the wound for monitoring, treatment and other purposes without removing the cover from the body. The wound treatment appliance can have a vacuum system to supply reduced pressure to the site of the wound in the volume under the cover. A suction bulb can he used lo provide a source of reduced pressure to the cover.

Abstract: A flexible, multilayer wound dressing with antibacterial and antifungal properties, together with methods for making the dressing. The dressing includes a layer of silver-containing fabric, a layer of absorbent material, and (optionally) a layer of flexible air-permeable and/or water-impermeable material. The dressing can be used for prophylactic and therapeutic care and treatment of skin infections and surface wounds (including surgical incisions), as a packing material, and as a swab for surface cleaning.

Abstract: The invention relates to a transdermal therapeutic system (TTS) which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system incorporates a back layer and an active substance-containing layer that includes at least one peptide and a carrier substance.

Abstract: An apparatus for sanitizing the skin area beneath a worn medical cast includes a thin elongate and flexible member made from a highly pliable material, the member including a distal end having at least one cleaning pad secured thereon. The thin elongate member is sized to be fitted between the skin of a cast wearer and the inner surface of a worn cast. In one version, disposable cleaning pads are releasably secured to the distal end of the elongate member.

Abstract: A transdermal drug delivery patch has an excipient matrix containing an agonist for administration across the skin of a user, with the matrix further containing a plurality of spaced apart hollow cilia filled with an antagonist, whereby if an abuser attempts to physically remove the agonist the cilia will break releasing the antagonist, or if the abuser attempts In use a solvent to remove the agonist the cilia will dissolve releasing the antagonist, thereby blocking the effect the abuser is attempting to attain by concentrating the agonist for oral ingestion or by hypodermic needle injection. The plurality of spaced apart hollow cilia further includes a release enhancing agent in association with the antagonist for increasing the release rate of the antagonist.

Abstract: A conformable barrier sheet comprising a polymeric film having a tensile elongation at least 2 fold greater than a polyethylene terephthalate film of equal dimensions and under an equal load; a planarization layer; and a plasma-deposited amorphous glass layer comprising silicon, carbon, and hydrogen; wherein the planarization layer is disposed on the polymeric film, the amorphous glass layer is deposited on the planarization layer, and wherein the barrier sheet is sufficiently conformable that after undergoing a tensile elongation within the range of more than 2% to 20%, the barrier sheet has a moisture vapor transmission rate essentially unchanged compared with prior to being elongated, a method of making the conformable barrier sheet, a transdermal device comprising the conformable barrier sheet, a method of delivering a drug to a mammal using the device, and a method of protecting an article using the conformable barrier sheet are provided.

Abstract: An apparatus, system, and method for storing liquid from a tissue site are presented. The apparatus includes a delivery tube that may have at least one lumen. The delivery tube may be operable to transmit reduced pressure to the tissue site and to receive liquid from the tissue site. The apparatus may also include an absorbent material disposed in the at least one lumen. The absorbent material may be operable to absorb the liquid from the tissue site. The delivery tube may be formed with a number of recesses.

Abstract: A method for using a dressing mechanism on an epidermis. The dressing mechanism includes a first section, a second section, and a third section and the first section and the third section comprise an elastic material and include a first side having an adhesive located thereon. The second section is a laminated material.

Abstract: The present invention relates to compositions including a homeopathic aqueous substance active (HASA) and at least one hydrophilic gelling agent, the HASA comprises a homeopathic compound at a potency of 30 C or higher and an uninhibited aqueous composition. The present invention also relates to methods of preparing a hydrophilic HASA-gel matrix. The method includes combining a homeopathic compound and an uninhibited aqueous composition to produce a HASA; combining the HASA with at least one hydrophilic gelling agent; and thereafter, forming the hydrophilic HASA-gel matrix by use of at least one of a thickening agent, a crosslinking agent, or a polymerization agent.

Abstract: Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the organic base. Compositions and transdermal systems are also described.

Abstract: Devices and methods are disclosed for achieving hemostasis in traumatized patients. Such haemostatic packing devices and methods are especially useful in the emergency, trauma surgery or military setting. In such cases, the patient may have received trauma to abdominal viscera, the thoracic cavity or the periphery. The devices utilize fluid impermeable outer surfaces and distributed pressure to achieve tamponade and hemostasis, primarily by exertion of pressure. The devices are flexible, bendable, and conformable in their wet or dry state so that they exert distributed pressure on the wound. Peripheral haemostatic packing devices include optional adhesive structures to attach one packing device to another. The hemostatic packing devices may be placed and removed by open surgery or laparoscopic access without generating excessive re-bleeding. The devices can be inserted into a wound and filled with fluid, gel, or particulates through an axially elongate tube to generate pressure to tamponade the wound.

Abstract: The present invention provides systems and methods for protecting wounds, such as surgical incisions. In one embodiment, a dressing for protecting a wound includes: a support cushion configured to surround the wound, the support cushion having sidewalls defining a major axis and a minor axis, the support cushion including at least two perforations that traverse the sidewalls at offset locations; a reservoir configured to be suspended over and in engagement with the support cushion; and a cover configured to be positioned over the reservoir. The at least two perforations may define first and second interlocking J-shaped portions. The support cushion may include a wicking portion configured to surround the wound and a hydrophobic portion configured to surround the hydrophobic portion. The wicking portion may be configured to transfer fluid from the wound to the reservoir. Methods of applying the dressing, and kits including the dressing, also are provided.

Abstract: Wound treatment apparatuses comprising a vacuum source and a bandage (e.g., a wound-care bandage) configured to be coupled (and/or coupled) to the vacuum source. Some embodiments of the bandage including a wound dressing member configured to be placed in contact with a wound surface, and a suction port associated with the wound dressing member and/or configured to be connected to the vacuum source. Some embodiments of the member including a plurality of spacers configured to contact the wound surface to define suction space between the member and the wound surface. Some embodiments of the member including holes configured to communicate with the suction space, and/or a plurality of passageways between the suction port and the holes.

Abstract: A wound dressing includes an absorbent core defining opposed proximal and distal surfaces including a central portion and a border portion, and a liquid impervious, vapor permeable backing layer connected to the distal surface of the absorbent core. The backing layer defines a border portion extending beyond the periphery of the absorbent core. A skin adherent, perforated facing layer is secured to the proximal surface of the absorbent core. An adhesive layer is applied to at least a proximal segment of the border portion of the backing layer and has greater skin adherence properties than the facing layer.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A wound dressing for use in negative wound pressure therapy includes a cover layer for positioning over a wound to define a reservoir over the wound in which a reduced pressure may be maintained. At least one vacuum port is affixed to the cover layer and includes a conduit receiving portion configured to receive a fluid conduit to provide fluid communication between the fluid conduit and the reservoir. The at least one vacuum port is configured to receive the fluid conduit from a plurality of directions relative to the cover layer.

Abstract: A liquid streaming device for treating a wound includes a body having a lower surface for application to skin region around the wound to be treated and to conform to the contour of the skin region, and an upper surface facing outwardly when the body is applied to the skin region; a recess formed in the lower surface of the body and configured to enclose the wound when the body is applied to the skin region, and to define a chamber closed on one side by the skin region and the wound, and on the opposite side by the body; an inlet in the body on one side of the recess for introducing a treating liquid into an inlet side of the chamber; and an outlet in the body on another side of the recess for outletting the treating liquid from an outlet side of the chamber.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Abstract: A preformed wound shield includes a frame formed of one or more layers of suitable material and any suitable covering. Exudate absorbing or transporting material may also be one of two or more layers of material forming the frame.

Abstract: An apparatus configured to provide a beneficial biological effect for a subject, and/or a method of treating the subject using the apparatus. The apparatus may be configured to trigger and maintain the elevation of Glutathione levels within the subject. The apparatus may rely on a non-invasive mechanism to elevate Glutathione levels in the subject. The apparatus may not require a traditional power source such as a battery or wall plug in order to be effective in elevating Glutathione levels in the subject. To trigger and maintain the elevation of Glutathione levels within the subject, the apparatus may transmit communication to the body of the subject that results in increased levels of Glutathione within the subject.

Abstract: A composite wound dressing apparatus promotes healing of a wound via the use of a micropump system housed within a wound dressing member. The micropump system includes a miniature pump that applies a subatmospheric pressure to the wound to effectively draw wound fluid or exudate away from the wound bed without the need for an external vacuum source. Hence, the wound dressing and micropump system is portable which allows the patient mobility that is unavailable when an external vacuum source is used. The patient does not need to be constrained for any period of time while exudate is being removed from the wound.

Abstract: The invention provides a device adapted to assist the sterilization of a limb surface, comprising a flexible tubular sleeve, closed at one end, shaped and sized so as to loosely fit, in use, around the limb of a patient whose limb surface is to be sterilized. The sleeve bas limb-sealing means, located close to or at each end of the sleeve, and each capable of forming, in use, a seal between the sleeve and the limb of a patient. The device is particularly suitable to assist in de-contamination of limbs prior to surgery thereon.

Abstract: A dressing assembly for use with a reduced pressure treatment system, the dressing assembly develops a directed force under reduced pressure. The directed force may be a radial force or a closing force. The dressing assembly includes a shaped dressing bolster having a shaped extremity that is operable to evenly deliver the radial force and to distribute reduced pressure. Numerous shapes may be used for the shaped extremity. The dressing assembly may further include an over-drape to assist in creating a seal over the shaped dressing bolster and against a portion of a patient's epidermis.

Abstract: The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide, and an active agent. The matrix may be formed into any desired shape for its desired uses.

Abstract: A silver composition comprising silver sulfate, methods of making antimicrobial articles, particularly packaged antimicrobial articles, methods of whitening antimicrobial articles, and packaged antimicrobial articles.

Abstract: A reduced-pressure, linear-wound closing bolster has a pivotable frame that moves from an extended position to a compressed position under the influence of reduced pressure. The closing bolster may have a first closing member, a second closing member, and an interior space. A manifold member is disposed within the interior space and may be coupled to the pivotable frame. When a reduced pressure is applied, the pivotable frame is urged from the extended position to the compressed position. A first gripping member for transmitting a closing force from the first closing member to a first edge of a linear wound may be attached. Likewise, a second gripping member for transmitting a closing force from the second closing member to a second edge of the linear wound may be attached. Systems and methods are also presented.

Abstract: A delivery product is used to deliver a skin composition to the skin of a user. The delivery product includes a thermo-responsive polymer film. The polymer film is solid at room temperature but, once contacted with the skin, increases in temperature and degrades. A skin composition is associated with the polymer film. The skin composition can be applied to a surface of the film or can be incorporated into the film. The skin composition is released by the polymer film for treating the skin of the user.

Abstract: A wound dressing member is provided for use in a vacuum bandage connected to a vacuum source and for use with a wound having a wound surface. The member may include a top surface and a bottom surface adapted to be in contact with and generally conform to the wound surface. The member may further include a plurality of discrete holes formed in the bottom surface and at least one discrete opening formed in the top surface. A port of the member may be provided to communicate with the vacuum source, each discrete hole, and the at least one discrete opening.

Abstract: An integrated wound dressing system and method including a bandage and a self-contained receptacle that stores treatment material for the care and treatment of wounds. The treatment material is easily accessible and can be removed from the receptacle through an exit. The treatment material can then be used to control bleeding and/or clean the wound before dressing. The bandage may include a layer of plastic that acts as an occlusion barrier to reduce heat loss and maintain moisture levels at the wound site. The occlusion barrier also acts to prevent the passage of air into or out of the wound site. The bandage also includes fasteners that act to prevent unintentional unraveling and to secure the bandage during final packaging. These fasteners help facilitate the wrapping of amputations, stumps, and extremities. The integrated wound dressing system provides an all-in-one system for treating and dressing wounds and reduces the time required to do so.

Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the self-supporting films are also disclosed.

Abstract: An antiviral transdermal patch including a backing layer, a viscous polymer layer, and a protection film layer. The viscous polymer layer includes an antiviral agent, a viscous polymer, and a transdermal enhancer. The transdermal enhancer is laurocapram or a mixture thereof. The antiviral agent is a nucleoside antiviral drug with a daily delivery rate of less than 100 mg/day. The patch effectively promotes the penetration of a nucleoside antiviral agent into the blood circulation and avoids enzymolysis in the gastrointestinal tract and the first pass effect of the liver and reduces side effect of drugs, thereby inhibiting the replication of target viruses and reducing viral DNA level in the serum. A method for producing the patch is also provided. The raw materials involved in the invention are easily purchased from the market at a low cost.

Abstract: The present invention discloses a medical device having a disposable member for treating dermatological diseases and topical pathogeneses. The device comprises, inter alia, at least one inner layer at least partially made of a non-woven material, being in physical contact with at least a part of the derma having the dermatological diseases; at least one external impervious and flexible layer, at least partially made of material selected from a group consisting of silicone, rubber and polymer, enveloping the inner layer; and, source of hypertonic solution wetting the inner layer such that the inner layer is continuously immersed with the hypertonic solution and a constantly hypertonic environment around the derma is maintained. The inner layer is disposable and reversibly detachable to the enveloping external layer such that frequent displacement of the inner layer is possible, topical pathogeneses are being removed and dermatological diseases are being treated.

Abstract: The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.

Abstract: The present disclosure describes a dressing for use in a vacuum wound therapy procedure to promote healing of a wound. The dressing includes a cover layer for positioning over a wound to define a reservoir in which a reduced pressure may be maintained over the wound. A portal member is mounted relative to the cover layer and defines a fluid passage for fluid coupling with a reduced pressure supply conduit for creating the reduced pressure within the reservoir. A filter screen is mounted relative to the fluid passage and is dimensioned to minimize passage of tissue particles of predetermined dimension through the fluid passage of the portal member.

Abstract: A wound treatment apparatus is disclosed, which comprises: a first portion, a second portion and a porous matrix. In an exemplary embodiment of the invention, the first portion, being an adhesive film, is formed with at least a first hole; and the second portion, being made of a flexible, water-resistant material, is formed with at least a second hole and at least a third hole in a manner that the at least one second hole and the at least one third hole are capable of communicating with each other and thus causes an accommodation space to be formed inside the second portion while the at least one second hole is arranged at a position corresponding to the at least one first hole as the second portion is connected to the first portion. Moreover, the porous matrix is received inside the accommodation space of the second portion.

Abstract: A system for treating a linear wound on a patient has a closing dressing bolster for placing on the patient's epidermis over the linear wound, a sealing subsystem for providing a seal over the closing dressing bolster and the patient, and a reduced-pressure subsystem for delivering reduced pressure to the sealing subsystem. The sealing subsystem and reduced pressure subsystem are operable to deliver reduced pressure to the closing dressing bolster. The closing dressing bolster is operable under reduced pressure to develop a inward closing. The closing dressing bolster may include one or more closing members on each side of a center wound area to create the inward closing when under reduced pressure. A compressive force may also be developed. Other systems and methods are presented.

Abstract: The present invention describes microbicidal hydrophilic polyurethane foams endowed with polyhexamethylenebiguanide (PHMB) and/or its hydrochloride and also a superabsorbent, wound contact materials obtainable therefrom and processes for producing the therapeutically endowed polyurethane foams and the wound contact materials obtainable therefrom.

Abstract: A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to the chamber wherein the drug is administered to the surface of the patient under pressure.

Abstract: A system for providing reduced-pressure treatment to a moveable tissue site, such as a joint, includes a flexible dressing bolster. The flexible dressing bolster has a first side and a second, inward-facing side, and a plurality of flexion joints formed on the flexible dressing bolster. The system further includes a sealing subsystem for providing a fluid seal over the flexible dressing bolster and the patient's epidermis and a reduced-pressure subsystem for delivering a reduced pressure to the sealing subsystem. The sealing subsystem and reduced-pressure subsystem are operable to deliver a reduced pressure to the moveable tissue site. The flexible dressing bolster is operable to allow articulation or movement of the moveable tissue site. The sealing subsystem may include a drape with folds. Other systems, apparatuses, and methods are presented.

Abstract: The present invention relates to a device for applying at least one product in a controlled manner onto a surface. The device comprises several layers, where a bottom layer and at least a storage layer are welded together during the manufacturing of the device in order to create a temporary liquid barrier in the storage layer. The temporary liquid barrier will form at least one closed chamber in the storage layer, where the purpose of the temporary liquid barrier is to delay the liquid running over the barrier after the storage layer has been filled with the liquid that is to be applied. This delay of the liquid running over the temporary liquid barrier will ensure that the rest of the different layers of the device can be joined together inside and around their outer peripheries, in order to create a liquid tight storage chamber for the product.

Abstract: The invention relates to a wound dressing, a wound contact layer and a medicinal composition comprising a hydrophilic base in which hydrocolloids are dispersed, wherein the hydrophilic base comprises at least one emulsifier and the use of said composition is for the treatment of wounds.

Abstract: The invention relates to a wound dressing, a wound contact layer and a medicinal composition comprising a hydrophilic base in which hydrocolloids are dispersed, wherein the hydrophilic base comprises at least one emulsifier and the use of said composition for treating wounds.