Abstract: An insect-bite itch stopper is disclosed which has a pressure surface adapted for pressing directly onto an insect bite and an applicator for simultaneously or contemporaneously applying an anti-itch medication to the bite.

Abstract: The invention relates to an application system for the transepidermal surface administration of medications, said system comprising a container (1) accommodating a sprayable, active agent-containing composition, a propellant gas source (3) for pressurized gas consisting of at least 25% v/v of oxygen, and a spraying device (2), wherein container (1), propellant gas source (3), and spraying device (2) are flow-connected with each other in such a manner that the propellant gas atomizes the sprayable composition and, when the spraying device (2) is actuated, forces it out of the spraying device (2), with the composition being forced out of the spraying device (2) in the form of a conical spray jet at an exit velocity of ?100 m/s. With the help of the inventive application system active agents can be effectively administered via the skin without causing injury to the skin. As a result of the high exit velocity the penetration rate is especially favorable even when larger molecules are introduced.

Abstract: A transdermal delivery system comprising a composition comprising a pharmacological agent and a penetration enhancer wherein the penetration enhancer comprises polyethylene glycol (PEG) of average molecular weight no more than 300.

Abstract: Embodiments disclosed herein are directed to fluid spraying apparatuses, and related systems and methods. The disclosed fluid spraying apparatuses may be used, for example, to spray a medically suitable fluid on a target region of a subject, such as for treating or removing tissue of the subject. In an embodiment, a fluid spraying apparatus includes a spray mechanism including at least one reservoir, and a spraying device operably coupled to the at least one reservoir which has an adjustable spray nozzle. The fluid spraying apparatus includes a distance sensor configured to sense information at least related to a distance to a target region of a subject and output one or more signals encoding the information, and control electrical circuitry operably coupled to the spray mechanism and the distance sensor. The control electrical circuitry is configured to activate the spray mechanism responsive to receiving the one or more signals.

Abstract: Embodiments disclosed herein are directed to fluid spraying apparatuses, and related systems and methods. The disclosed fluid spraying apparatuses may be used, for example, to spray a medically suitable fluid on a target region of a living subject such as for treating or removing tissue. In an embodiment, a fluid spraying apparatus includes a target designation unit having a target sensor configured to sense a target region of a living subject, a spray mechanism, and a controller. The spray mechanism includes at least one reservoir configured to hold fluid, and a spraying device operably coupled to the at least one reservoir, the spraying device configured to spray the fluid in the at least one reservoir onto the target region. The controller includes control electrical circuitry operably coupled to the spray mechanism and the target designation unit, and configured to control the spray mechanism responsive to the target sensor sensing the target region.

Abstract: A medical grade cleansing and numbing agent combination pad is disclosed. An example combination pad includes a pad impregnated with a cleansing agent and a numbing agent each in separate layers. Both the cleansing agent and the numbing agent are released through a same side of the pad without a user having to turn the pad over to apply both the cleansing agent and the numbing agent to a treatment area at substantially the same time. A barrier prevents the numbing agent from contacting the user during application to the treatment area.

Abstract: A personal care product that includes a personal care composition disposed in a collapsible bag at least partially surrounded by an elastically deformable member and, optionally, an outer container body. The elastic member is constructed of an elastically extensible material that permits the transfer of infrared radiation through at least a portion of the elastic member. Potential energy is generated by stretching the elastically deformable member, which is used to dispense the composition in lieu of a propellant or pump. The container may also include a actuatable valve for dispensing the composition.

Abstract: A spray nozzle for applying a medicinal agent to a tissue. The spray nozzle comprising a tip housing and a valve. The tip housing has a distal end, a proximal end, and a lumen that extends between the ends and defines a lengthwise central axis. The valve has an elongated body that extends through the lumen of the tip housing, along the lengthwise central axis. The valve, being configured to slide within the lumen of the tip housing, in an extended position with respect therewith is configured to disperse the medicinal agent toward the tissue. When the valve is in the retracted position with respect to the tip housing, the medicinal agent is vented away from the tissue.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A clip receives a barrel of the syringe. The clip includes a receptacle portion receiving a pre-filled cannister of a topical numbing agent, wherein the cannister includes a generally cylindrical chamber portion receivable within the receptacle portion of the clip and a distal neck portion having an outlet allowing contents of the cannister to be dispensed. A dispenser attached to the distal neck portion of the cannister includes an elongated flexible tube surrounded by a rigid tube for at least a portion of a length of the elongated flexible tube. A pivotable lever carries a tube compressor including a pinching member extending through an opening in the rigid tube and spring biased to a position at which the pinching member pinches closed an elongated passageway through the flexible tube.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A pair of clips receive a barrel of the syringe. The clips are on a housing receiving a pre-filled cannister of a topical numbing agent and including a chamber. The cannister includes an aerosol dispensing valve actuated by a button which when pressed moves the cannister with respect to an actuator for the valve.

Abstract: Described herein are systems, apparatuses, and methods that employ a medical device to augment delivery of an agent to biological tissue. The medical device includes a reservoir containing the agent, a release port, and sealable base that can be attached to the biological tissue so that the agent is held under pressure upon attachment. The device can only release the agent through the release port. A penetrating instrument can be utilized to augment delivery of the agent to the biological tissue.

Abstract: This invention relates to an implement 1 for applying a volume of liquid to a treatment surface. The implement includes a support means 3 onto which is mounted a receptacle 2, the receptacle defining a reservoir space 4 which receives the liquid. The receptacle includes a wall 6 having a working surface that is used to spread the liquid over the treatment surface. The wall 6 is resiliently deformable so in use the working surface maintains contact with the treatment surface when spreading the liquid. The implement has a specific application in applying a transdermal lotion to the axilla area of the user. The invention also relates to a system for transdermal administration of a physiological active agent from a liquid composition and a method of conducting the same.

Abstract: A topical foam pharmaceutical composition for rectal administration comprising rifaximin in the form of nanosized particles is described. Also described is a method of making the composition and the use of the composition to as a medicament.

Abstract: Embodiments provide a medical device in the form of an applicator for applying a medical composition to a patient. The applicator includes a body, a tip, and a delivery mechanism. The body defines a storage chamber for the medical composition and has an opening for deploying the medical composition from the storage chamber. The tip covers the opening and has a closed state wherein the tip maintains the medical composition in the storage chamber and an open state wherein the medical composition can be deployed through the opening and the tip.

Abstract: A device for scar management includes an applicator head including a recess having a rotating means therein, a reservoir containing a silicone composition fluidly connected to the applicator head, and a metering valve fluidly connected to the reservoir. A metered dose of the silicone composition is delivered from the reservoir to the applicator head upon the application of external pressure to the metering valve. The invention also relates to a method for scar management using such device by identifying a target skin area having a wound or scar, contacting the outward surface of the applicator head to the target skin area, massaging the rotating means of the applicator head on the target skin area, and applying the silicone composition to the target skin area via the rotating means.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A medical skin applicator apparatus includes a fluid housing having a fluid chamber for storing a medical agent and an applicator coupled to the housing. The fluid housing has a penetrable wall to permit access to the fluid chamber and release of the medical agent therefrom. The applicator includes an applicator surface for applying the medical agent to a patient. The applicator has a penetrating member adapted to penetrate the penetrable wall of the fluid housing upon achieving a predetermined coupled relation of the fluid housing and the applicator, to thereby permit the medical agent to be dispensed from the fluid chamber and applied to the patient with the applicator surface.

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative and a corticosteroid, and its use in the treatment of dermal diseases and conditions. The spray comprises especially a propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethyl ether or a mixture thereof and further a pharmaceutically acceptable lipid carrier solubilised or suspended in said propellant.

Abstract: A device for applying lotion to a user's body has a foam layer. A cover layer is applied to a top surface of the foam layer. A pair of openings formed through the foam layer and the cover layer. A reinforcement layer is applied around each opening.

Abstract: According to some embodiments, a system for treating skin includes a handpiece assembly comprising a tip and a main body portion, the main body portion comprising an interior cavity and at least one canister configured to store at least one of a treatment material and a waste material. The treatment material and/or the waste material is in fluid communication with the tip.

Abstract: The application provides a device for applying a formulation to skin, the device comprising a housing, a spreading means, and an ejecting means; wherein the housing comprises a chamber for receiving a cartridge, and wherein the cartridge comprises a formulation.

Abstract: A built-in non-verbal compact instructional device integratable to an applicator having a microdevice for painlessly perforating skin and optionally an active agent for application to the perforated area. The microdevice can include microneedles, microneedle arrays, microblades, microblade arrays, microknives, microknife arrays, and Functional MicroArrays (FMAs). The active agent can be stored in a first chamber. The microdevice can perforate stratum corneum without significant pain or discomfort to a patient. The active agent is applied to the perforated area. The device verifies compliance with predetermined methods of use, such as a light to indicate application with the recommended amount of force for perforating skin. The applicator can provide enhanced delivery of an active agent, with minimal discomfort, for therapeutic or cosmetic treatment, such as topical treatment for acne, or other skin disorders, wrinkles, blemishes, etc.

Abstract: An emergency medication storage and integrated single use device for providing oral dissolving medications strips in a convenient transparent transfer environment. A thin card size dispenser holds a single medicated strip in user access orientation positioned for direct card insertion to the user's mouth assuring proper dispensing of the medication in an emergency situation.

Abstract: A skin topical applicator apparatus includes an arm that has a first end and a second end. A cavity is positioned in the arm and is adjacent to the first end. A mount is attached to the arm and extends away from the first end of the arm. A roller is rotatably attached to the mount. A canister is removably mounted in the cavity and a nozzle is fluidly coupled to the canister and extends outwardly of the first end. The nozzle is directed toward the roller. The canister is filled with a fluid under pressure. The canister includes a valve that is actuated to release the fluid into the nozzle to coat the roller with the fluid.

Abstract: A system and method of topically applying an anesthetic, or other medication, to one or both lips of the mouth. An applicator device is provided that has a curved first wall, a curved second wall, and a horizontal shelf that joins the first wall to the second wall. The first wall, the second wall and the horizontal shelf combine to define either one or two curved lip compartments. A volume of the anesthetic, or other medication, is placed within the curved lip compartments. The applicator device is partially placed in a person's mouth so that the second wall is positioned between the back of the lips and in front of the teeth. While in this position, the lip of the user passes into the curved lip compartment and is contacted by the anesthetic.

Abstract: There is provided methods for administering a toroidal pharmaceutical composition to a subject. The method includes dispensing a toroidal pharmaceutical composition, and allowing the toroidal pharmaceutical composition to contact a target organ of the subject, thereby administering the toroidal pharmaceutical composition. There are additionally provided toroidal aerosol delivery systems.

Abstract: An antiseptic applicator device having a reservoir for storing an antiseptic agent, the reservoir being coupled to an applicator pad, and a defeatable membrane being interposed between the reservoir and the applicator pad. Embodiments of the device further include opposing handles, wherein an interior lumen of each handle houses a breakable phial containing a desired solution, and wherein upon moving the handles to a closed position, the phials are broken to release the desired solutions which are then absorbed by the applicator pad.

Abstract: Apparatus and methods are provided for the purpose of applying topical treatment on the skin in a standardized and fractionated way. In one aspect of the inventive subject matter, a device includes a trigger activating a pump, which is continuous with a passageway that drains fluid from a reservoir to nozzle. The trigger is operatively coupled to the pump. The pump forces a predetermined volume of fluid to leave the nozzle at a predetermined distance from the skin.

Abstract: Disclosed are advances in the arts with novel topical applicator apparatus for applying substances such as cleansers, cosmetic preparations and medications to the skin. The apparatus includes an applicator body having a power portion connected with an impulse portion, which in combination with an applicator head, transmits one or more various impulses to the skin supplemental to the substance applied. Exemplary preferred embodiments include configurations for providing mechanical and/or electrical or other impulses.

Abstract: The present invention is directed to a delivery device and method for the sequential delivery of a topical pain relieving composition and an occluding composition. These two compositions are held in a single device that comprises at least two chambers for manual and or pressurized delivery of these compositions to the patient's skin.

Abstract: An apparatus includes a substrate and a wall coupled to the substrate. The substrate and the wall define a medicament reservoir. At least a portion of the wall is configured to be deformed to reduce a volume of the medicament reservoir when the wall is actuated. The wall includes an actuation portion, which can be used to actuate the wall. The portion of the wall is configured to deform at a first rate when the actuation portion is in a first configuration, and a second rate when the actuation portion is in a second configuration.

Abstract: A flexible, body attached device is disclosed for dispensing skin treatment and topically-absorbed medicinal treatments. The device comprises a dispensing reservoir that is caused to dispense treatment through a slit-based diaphragm valve upon the application of simple pressure to the device. Various embodiments of the invention include variations in the structure of the valve, reservoir, and body attachment.

Abstract: A spray delivery system in combination with a scalp medication is provided which includes a portable container having a gas imperious container wall, a pressure source disposed within the container, and a selectively operable valve assembly affixed to the container. The scalp medication is in liquid form and is disposed within the container. The scalp medication comprises a hair growth stimulation or hair growth maintenance active ingredient in an amount sufficient to stimulate or maintain hair growth disposed within a pharmacologically acceptable carrier solution. The valve assembly of the system produces a 1 mL spray of said scalp medication within about 5 seconds following a single operation of said valve assembly. A method of treating alopecia using a continuous spray employing such a system is also provided. Both bag-on-valve (bag-in-can) and metered dose packages are disclosed.

Abstract: A device for applying lotion to a user's body has a foam layer. A cover layer is applied to a top surface of the foam layer. A pair of openings formed through the foam layer and the cover layer. A reinforcement layer is applied around each opening.

Abstract: A method for irrigation of a wound, wherein the method involves the use of a reservoir housing containing a wound irrigation solution and a discharge means attached thereto, wherein the discharge means has multiple ports for directing a stream of the solution at a wound at an appropriate pressure.

Abstract: Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization processes. In some embodiments, the container may include flexible walls free of metallic foil barrier layers. The containers may also include one or more vents in addition to one or more openings used to dispense the skin antiseptic composition within the container. The dispenser may include an applicator with a hydrophilic foam.

Abstract: A fluid delivery device includes a compressible sleeve configured to hold a fluid-holding container such as an ampoule or capsule. The sleeve is compressible so as to be able to shatter the container under user-applied force to release the contents of the container for application to a desired location. The sleeve is constructed from at least two independent and separate walls. The independence of the walls improves the resistance of the sleeve to accidental puncturing by the frangible container while not significantly impacting the force required to shatter the container.

Abstract: A device for the delivery of medicinal liquids, in which the device includes a base configured for sealing attachment to a container pre-filled with liquid medicine and a displaceable actuator element associated with the base. The association is that of a piston and a cylinder such that the base and the displaceable actuator element define between them a pressure generating volume. The base includes a piercing element having at least one air delivery passage providing fluid communication between the pressure generating volume and an interior of the container, the piercing element also includes at least one liquid delivery passage providing fluid communication between the interior of the container and a medicinal delivery element.

Abstract: A medical skin applicator apparatus includes a fluid housing having a fluid chamber for storing a medical agent and an applicator coupled to the housing. The fluid housing has a penetrable wall to permit access to the fluid chamber and release of the medical agent therefrom. The applicator includes an applicator surface for applying the medical agent to a patient. The applicator has a penetrating member adapted to penetrate the penetrable wall of the fluid housing upon achieving a predetermined coupled relation of the fluid housing and the applicator, to thereby permit the medical agent to be dispensed from the fluid chamber and applied to the patient with the applicator surface.

Abstract: The present invention is directed to an intermittent aerosol dispensing device, for application of a product to skin of a human being, where the aerosol dispensing device includes an intermittent injection mechanism located downstream of an aerosol valve of an aerosol dispenser and responsive to a pushbutton of the aerosol dispensing device, and the aerosol dispensing device further includes a pressure chamber. A ratio of an injection time to a stop time is set, in said intermittent injection mechanism, to 0.1 to 5.0, so that when said aerosol valve is opened a cycle of injection and stop is performed 1 to 25 times per second in order to obtain a cooling and/or massage effect on the skin.

Abstract: A barrier of a vacuum pump prevents contamination from entering a vacuum pump air line. The barrier separates parts of the pump and is moveable between an initial state and a distended state. The barrier is assembled within the pump with a pre-load. When the vacuum source is applied to the barrier, the barrier achieves a distended state and when the vacuum source is released, the barrier incrementally self returns to an initial state. The geometry and material construction of the barrier, along with the pre-load, assists in returning the barrier on its own to the initial state from the distended state.

Abstract: A method of topically applying natural plant product for dissipation of human adipose tissue, comprising: (a) topically applying an inner portion of a natural plant product to an epidermal layer exterior to adipose tissue to be dissipated of a user's body for a period of time, upon which a percentage of the adipose tissue softens and dissolves, thus, reducing the adipose tissue of the user's body; (b) removing the topically applied inner portion of the natural plant product from the epidermal layer for another period of time; (c) repeating steps (a) and (b); and weight reduction apparatus comprising a topical applicator having a receiving container adapted to removably receive a natural plant product and having an opening or a porous wall adapted to facilitate pulp, juices, and/or extracts of the natural plant product to contact a user's epidermal layer exterior to the adipose tissue to be dissipated.

Abstract: An oral disposable apparatus to deliver a fluid, e.g., pharmacological agent to a patient in a one handed easy to use and sanitary manner. The apparatus includes a container capable of holding the fluid. The container is hermetically sealed with a specified quantity of fluid. A nozzle is coupled to the container. The nozzle is configured to permit comfortable insertion into a patient's mouth. An integral valve is coupled to the container and the nozzle. The valve is configured to be activated via rotation of the nozzle, thereby releasing the fluid.

Abstract: Compositions and methods for delivery of medicaments to human or animal skin, for example, the scalp, comprising the steps of transporting the medicaments in a volatile carrier solution to a position adjacent to the skin, and atomizing the preparation at said position onto the skin to thereby uniformly distribute the preparation over the scalp thereby improving absorption of the medicament through the skin.

Abstract: A method for using a dispensing apparatus having a fluid insert with an airless channel configured for labial, vaginal, transmucosal, and transdermal delivery of a therapeutic substance is disclosed.

Abstract: Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization processes. In some embodiments, the container may include flexible walls free of metallic foil barrier layers. The containers may also include one or more vents in addition to one or more openings used to dispense the skin antiseptic composition within the container. The dispenser may include an applicator with a hydrophilic foam.

Abstract: A bottle is for containing a fluid, and includes: a grippable bottle body having a size that can be gripped by one hand, the bottle body having a surrounding wall defining a receiving space, and an opening connected fluidly to the receiving space; a cap to close the opening in a fluid-tight manner; and at least one spreading unit that includes a roller rotatably disposed on the surrounding wall outwardly of the receiving space and at a location away from the opening, the roller being rotatable on a surface to spread the fluid when the bottle body is gripped by one hand and is moved relative to the surface.

Abstract: The present invention is directed to airless storage and dispensing systems that include a pump or dispensing package pre-filled with a topical semi-solid imiquimod pharmaceutical formulation (“pump systems”) and methods for storing and dispensing from the pump systems a plurality of precisely measured and uniform unit doses of a topical semi-solid imiquimod pharmaceutical formulation, and more particularly to pump systems, pre-filled with a topical imiquimod pharmaceutical cream and methods for delivering multiple precisely measured unit doses of a topical imiquimod pharmaceutical cream, and methods for using a controlled delivery pump system to store and dispense a plurality of consistent and precisely measured unit doses of a topical imiquimod pharmaceutical cream for use in topically treating a dermal and mucosal-associated condition, such as, external genital warts and/or perianal warts (EGWs), actinic keratosis or actinic keratoses (AK or AKs) and superficial basal cell carcinoma (sBCC).

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective irrigation of abscesses, puncture wounds, and similar types of deep tissue wounds. In one embodiment the subject invention provides a discharge apparatus for a reservoir housing containing irrigation solution, wherein the discharge apparatus has a specifically designed nozzle for insertion into a wound opening and through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: A liquid delivery device is provided which allows for delivery of precise, small amounts of a target liquid, such as cantharadin, glycolic acid, phenol, trichloroacetic acid, or similar liquids to a specific, discrete target location, such as an area of the skin to treat conditions including, but not limited to: molluscum contagiosum, verrucous vulgaris (warts), verrucous plana (flat warts), acne scars, actinic keratosis, acrochordon (skin tags), seborrheic keratosis, dermatosis papulosa nigra, milia and lentigo (sun spots). The liquid delivery device allows for delivery of the liquid to the target area without delivering the liquid to any part of the area surrounding the precise target location, thereby eliminating unnecessary irritation such as blistering, pain, temporary or permanent tissue damage and/or scarring for the user. The liquid delivery device strongly adheres to the target liquid, eliminating spilling and the resultant danger to the user and eliminating economic waste.