Abstract: An applicator assembly includes a body having a proximal and a distal end, a container slidably coupled to the body, a valve cap coupled to the container, and an application member attached to the distal end, wherein an interior of the container is placed in fluid communication with the application member by way of a fluid conduit that is only accessible when one of the body and the container are axially translated in an opposite direction away from each other.

Abstract: An applicator for applying a substance to an intended surface. The applicator may include a main body including an elongated handle and an elongated tip configured to hold a predetermined amount of the substance. Further, the applicator may include an extension which extends radially from the main body in an area proximate to where the handle meets the tip and a breakaway section including an elongated sleeve which extends in a direction perpendicular to at least a portion of the tip and extends from the extension in an area proximate to a terminal end of the extension. Further, the elongated tip may extend from the handle in an area proximate to where the extension extends from the main body. Additionally, the applicator may be a single, integral piece such that the handle, the elongated tip, the extension and the breakaway section are integral with each other.

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation. In one embodiment the subject invention provides a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

Abstract: A device for administering a therapeutic substance includes a sealed package and an administration assembly. The sealed package includes a collapsible compartment containing the substance. The administration assembly includes a dispenser that is in fluid communication with the substance. At least one compression member is movable by linear actuation to progressively collapse the collapsible compartment and urge the therapeutic substance through the dispenser.

Abstract: A personal care product that includes a personal care composition disposed in a collapsible bag at least partially surrounded by an elastically deformable member and, optionally, an outer container body. The elastic member is constructed of an elastically extensible material that permits the transfer of infrared radiation through at least a portion of the elastic member. Potential energy is generated by stretching the elastically deformable member, which is used to dispense the composition in lieu of a propellant or pump. The container may also include a actuatable valve for dispensing the composition.

Abstract: Compositions, methods and systems for treating disordered epithelial tissues, such as is caused by pathogens and/or by toxins produced thereby. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium halide compound, preferably benzalkonium chloride. The inventive compositions and methods may employ the use of an applicator adapted for use in promoting the penetration of the treatment composition and/or the vigorous agitation of the disordered tissue.

Abstract: A mucous suction device, comprising in combination, a longitudinally elongated, generally tubular, one-piece plastic body, the body having an axially elongated tapered, first portion extending toward an inlet proximate one end of the body, the body having an axially elongated second portion extending toward an outlet proximate an opposite end of the body, radially outwardly extending annular retention rings in said body second portion, said rings having sharp annular peripheries and said rings being axially resiliently flexible and axially spaced apart, and there being body side porting between said body first and second portions, said side porting being manually controllable to control suction exertion.

Abstract: A device for wound irrigation which has a compressible reservoir housing with a sterile wound irrigation solution and a plurality of ports to facilitate producing a pressurized dispersed stream of wound irrigation solution.

Abstract: A unitary device for exfoliating and applying emollient balm to lips of a user. The device is in the form of a hollow body having a longitudinal axis and extending from a first end thereof, a brush having bristles emanating from a support and an applicator extending from a second end of the hollow body together with the supply of emollient balm.

Abstract: The invention relates to a method for the targeted application of a liquid medicinal treatment medium for topical treatment of a human or animal body in an area to be treated. The treatment medium is applied using at least one pin-like applicator.

Abstract: Splash shield systems for use with wide mouth irrigation squeeze bottles and other irrigation fluid sources.

Abstract: The invention is directed to a system for treating vomiting comprising a topical gel placed within a syringe. The topical gel includes (a) between 10 to 40% Phenergen by weight, (b) between 30 to 50% of lecithin isopropyl palmitate solution by weight, and (c) between 30 to 70% of pluronic gel by weight. The syringe includes a cylindrical chamber having a front end, a back end, an interior side and exterior side. The syringe has a disposing opening located on the front end of the cylindrical chamber; a stopper of a sufficient size and dimension to engage the disposing opening; a plunger located within the cylindrical chamber; a rigid shaft having a sufficient size and dimension to fit within the cylindrical chamber and a plate affixed to a distal end of the rigid shaft. The syringe is plastic having a dark color to prevent degradation of the topical gel.

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation. In one embodiment the subject invention provides a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: An ultrasound apparatus capable of mixing and/or atomizing fluids is disclosed. The apparatus includes a horn having an internal chamber, containing at least one free member, through which fluids to be atomized and/or mixed flow. Connected to the horn's proximal end, a transducer powered by a generator induces ultrasonic vibrations within the horn. Traveling down the horn from the transducer, the ultrasonic vibrations induce the release of ultrasonic energy into the fluids to be atomized and/or mixed as they travel through the internal chamber. As the ultrasonic vibrations travel through the chamber, the fluids within the chamber are agitated and/or begin to cavitate, while the free member moves about the chamber, thereby mixing the fluids. Upon reaching the front wall of the chamber, the ultrasonic vibrations echo off the front wall and pass through the fluids within the chamber a second time, further mixing the fluids.

Abstract: This invention relates to devices and methods for safely reconstituting and administering topical therapeutic or cosmetic compositions. The topical applicator according to the invention is particularly well suited for storing, reconstituting, and administering or applying highly toxic substances.

Abstract: An applicator for dispensing a therapeutic agent to an animal comprising a housing including first and second sections coupled together, the first and second sections defining a channel therebetween that includes at least one outlet; a hub integral with the first section and extending therefrom, the hub defining a conduit; and a bent path connecting the conduit to the channel. In accordance with this embodiment, the conduit, the bent path and the channel are fluidly connected.

Abstract: A low ether gel composition for application to skin comprising a keratolytic agent, in particular salicylic acid, and comprising a nitrocellulose and one or more volatile ingredients, which forms a film on contact with skin adequate to form a protective barrier for the keratolytic agent for a period of time necessary to provide treatment to the skin; methods of treating using such compositions, and dispensers containing such compositions.

Abstract: The container for fluid products, particularly creams, ointments, pastes, lotions for medical, pharmaceutical or cosmetic use, comprises a containment body for containing a fluid product which has an exit mouth for the fluid product, a closing element for closing the mouth, and an applicator element associable with the containment body near to the mouth and suitable for dispensing the fluid product exiting from the mouth.

Abstract: A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.

Abstract: An antiseptic applicator device having a reservoir for storing an antiseptic agent, the reservoir being coupled to an applicator pad, and a defeatable membrane being interposed between the reservoir and the applicator pad. Embodiments of the device further include opposing handles, wherein an interior lumen of each handle houses a breakable phial containing a desired solution, and wherein upon moving the handles to a closed position, the phials are broken to release the desired solutions which are then absorbed by the applicator pad.

Abstract: Embodiments of the present invention relate to a cosmetic treatment method that treats the human scalp, including applying a cosmetic composition and/or a gas to the scalp with a spray device operating with a compressed gas, a mean size of the sprayed particles of composition lying in the range 10 ?m to 35 ?m.

Abstract: A sprayer device and related method that delivers multicellular aggregates in suspension. A purpose of the sprayer embodiment may be to deliver cells into chronic wound beds, and additional purposes of the sprayer include additional application in other cell delivery environments, such as during open-heart surgery or other surgeries where it may be desirable to treat internal organs with aggregates of stem cells.

Abstract: Compositions of zolpidem, and methods for their manufacture and use for treating insomnia. The compositions are formulated as oral sprays for transmucosal absorption of zolpidem. The methods of treatment in some cases involve night-time dosing administration to achieve therapeutic zolpidem blood levels within 20 minutes or less, tapering off to less than 20 ng/ml within less than five hours, in some cases less than four hours, post dosing.

Abstract: A nasal spray apparatus for simultaneously administrating metered amounts of multiple medicaments includes chambers for separately storing incompatible medicaments, such as an antihistamine and a steroid. Reciprocal piston pumps allow the medications to be sprayed into the user's nasal cavity. Two pumps can be used to separately transfer the medicaments to a receptacle where they can be initially mixed just prior to administration. A small volume receptacle is used to reduce the amount of mixture remaining after each stroke of the nasal spray apparatus. A check valve can be associated with each pump to further reduce medicament mixtures from cross contamination within storage chamber preparations. Collapsible components, including collapsible storage chambers or balloon capacitors can be employed to compensate for vacuums and back pressures as the medicaments are pumped to a spray nozzle.

Abstract: A containment arrangement for safely and effectively treating a wound on a patient without contaminating attending personnel. The arrangement comprises a patient receiving first enclosure having a patient contacting periphery, a pressurizable source in communication with the patient through a wall of the enclosure for enlarging the enclosure, and a sealing means arranged in the patient contacting periphery. A hand manipulable fluid discharge nozzle is extendably arranged through the enclosure for providing controllable treatment fluid to the wound on the patient within the enclosure.

Abstract: A nasal irrigation device includes a container for storing nasal cleansing fluid, a spout having a connecting end, a nose engaging end and a spout passage, the connecting end of the spout being removably coupled to the container to allow the spout passage to receive nasal cleansing fluid from an opening of the container, the spout having a curved portion for directing nasal cleansing fluid toward a nasal passageway of a user when the container is clear of a nasal discharge path, the spout passage being continually open and unobstructed. The container is partially collapsible to force nasal cleansing fluid through the spout passage and into the nasal passageway.

Abstract: A method and apparatus for applying a cream, lotion, medicament, ointment, or other liquid from a disposable, single-use applicator that made be used with one hand. The assembly includes a flexible, low-rigidity container adapted to carry the agent therein. The assembly is formed with a container portion and an applicator tip, with the agent held inside by a perforated seal which is broken with a squeeze.

Abstract: A transdermal delivery system comprising a composition comprising a physiologically active agent and a penetration enhancer wherein the penetration enhancer comprises a combination of (i) an ester of salicylic acid, preferably selected from the C6 to C30 aliphatic ester of salicylic acid and (ii) polyethylene glycol (PEG) of average molecular weight no more than 300.

Abstract: The present invention relates to a disposable nozzle for inserting into a hand piece for treating and cleaning wounds by means of a highly focused high-pressure micro water jet. The disposable nozzle comprises a cylindrical nozzle body having a centrally traversing orifice body duct, which is laterally closed, as well as a cylindrical orifice with a centrally traversing orifice duct. The orifice is disposed in a recess that is centrally arranged in the frontal terminal region of the nozzle body at the front side in such a manner that both ducts adjoin to each other in a coaxial manner. An O-ring is disposed in the recess between the nozzle body and the orifice in a clamping manner, wherein the O-ring centrally retains the orifice in the nozzle body.

Abstract: A medical skin applicator apparatus includes a fluid housing having a fluid chamber for storing a medical agent and an applicator coupled to the housing. The fluid housing has a penetrable wall to permit access to the fluid chamber and release of the medical agent therefrom. The applicator includes an applicator surface for applying the medical agent to a patient. The applicator has a penetrating member adapted to penetrate the penetrable wall of the fluid housing upon achieving a predetermined coupled relation of the fluid housing and the applicator, to thereby permit the medical agent to be dispensed from the fluid chamber and applied to the patient with the applicator surface.

Abstract: A transdermal delivery system comprising a composition comprising a pharmacological agent and a penetration enhancer wherein the penetration enhancer comprises polyethylene glycol (PEG) of average molecular weight no more than 300.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A medicament applicator for use with a medicament cartridge is disclosed herein. The applicator comprises a first handle member and a second handle member, both of which are movable with respect to one another between a first handle position and a second handle position. The applicator further comprises a first separating member and a second separating member, which are movable between a first separating position, which corresponds to the first handle position, and a second separating position, which corresponds to the second handle position. The applicator further comprises a compressing apparatus attached to the applicator, which compresses the medicament cartridge and selectively expels the medicament from the medicament cartridge.

Abstract: A squeezable hermetically sealed vessel contains a whitening compound and an elongated applicator tip extending outwardly from the vessel. A cap closed and seals the applicator tip and the vessel, but may be removed under manual force. Once the cap is removed, the walls of the vessel may be squeezed together to urges the contents of the vessel to flow through a fluid passage through the elongated applicator tip to reach an accommodating surface. The accommodating surface may either be impregnated with a different material that reacts with the contents of the vessel upon contact or covers a chamber that in turn contains such a different material.

Abstract: The invention relates to a dermal flowable-composition dispenser that includes a body for retaining a supply of the composition, an application portion having an application surface, and a conduit connecting the supply chamber with the application surface for facilitating the reproducible delivery of a predetermined dose of the composition to the application surface. The application surface includes a concave application surface and a front side having an upper rim enclosing the application surface and forming a depression that has a volume that is greater than or equal to the volume of the predetermine dose. Also, the application surface is configured and dimensioned such it can receive the patient's skin to allow for removal of the predetermined dose of the composition, and wherein the concave application surface is shaped such that the entire application surface contacts the patient's skin when the application surface is pressed thereagainst.

Abstract: The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and/or in using the device, donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10.

Abstract: A tube dispenser adapted to apply antimicrobial gel beneath a user's fingernails includes a rotatable knob coupled to a piston with a threaded rod so that rotation of the knob advances the piston, extruding antimicrobial gel through an applicator tip.

Abstract: The present invention concerns a device for metering products intended to be applied to the skin, in particular pharmaceutical or cosmetic compositions. The invention relates more particularly to a device taking the form of an applicator stick, the graduations of which allow users to determine precisely the quantity of medication to be applied to the skin as a function of the surface area to be treated.

Abstract: A hand-held applicator is defined for applying a viscous product, such as a pharmaceutical product to the skin. The applicator includes a substrate with a flat face defining multiple dosing areas of the product. The product can be dispensed from a tube in a first area for a first recommended dosage and in combination in a first area and a second area for a second recommended dosage. Once the desired dosage is dispensed, the applicator is used to apply to product to an affected area of the skin.

Abstract: A flexible protective cover for preventing fluid from entering an open epidermal site on a user, comprising: a central portion having at least one rib, an edge connected to the central portion at an angle, a lip disposed around the edge, a sealing member disposed over the lip for providing a sealing engagement between the lip and the open epidermal site, and at least one adjustable strap removably connected to the central portion. Also disclosed is a flexible protective cover having a central portion, an edge connected to the central portion at an angle, an inflatable sealing member integral with the edge for providing the sealing engagement, and at least one adjustable strap removably connected to the central portion.

Abstract: An applicator directly delivers one or more active ingredients, such as flea, tick, or insect repellant to an animal's skin. The applicator comprises an applicator base connected to an applicator head having at least on prong member constructed with an internal channel therein in communication with a delivery aperture. A separately presented cartridge having a solution tube is appointed to be removably received within the applicator's base which, in turn is uniquely sized and shaped to receive a preselected one of those cartridges currently sold under recognized medicament brands. As the cartridge is squeezed, the solution traverses from the cartridge and applicator base into the applicator head and through the internal channels of the prong members, exiting through the delivery apertures onto the animal.

Abstract: The subject invention provides novel, inexpensive, and highly effective methods and devices for convenient and effective wound irrigation. In one embodiment the subject invention provides a discharge means for a reservoir housing containing irrigation solution wherein the discharge means has one or more specifically designed nozzles through which a sufficient volume of the irrigation solution can pass at an appropriate pressure.

Abstract: A method for preventing infection and maintaining aseptic epidermal areas by preventing contaminated fluid from entering an open epidermal site on a user, comprising the steps of: removably attaching at least one adjustable strap to a reusable non-deforming flexible protective cover comprising a sealing member, covering the open epidermal site with the reusable non-deforming flexible protective cover while maintaining a space between the reusable non-deforming flexible protective cover and the open epidermal site, and tightening the at least one adjustable strap to secure the reusable non-deforming flexible protective cove over the open epidermal site to create a fluid-tight seal between the sealing member and the open epidermal site, thereby preventing contaminated fluid from entering the open epidermal site.

Abstract: A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.

Abstract: The present invention is directed to a delivery device and method for the sequential delivery of a topical pain relieving composition and an occluding composition. These two compositions are held in a single device that comprises at least two chambers for manual and or pressurized delivery of these compositions to the patient's skin.

Abstract: A marking tool for use in the context of radiological and other medical imaging is disclosed. The product is a marking tool for distributing an imaging material onto a patient's skin to mark that part of the patient's body for imaging. The imaging technician then knows the area of medical interest, such as an internal injury, and can image that area more accurately. The imaging material shows up on a resulting medical image such as an X-Ray, CT Scan, or MRI to direct a radiology professional to the most important area on the image for diagnostic purposes.