Container For Blood Or Body Treating Material, Or Means Used Therewith (e.g., Needle For Piercing Container Closure, Etc.) Patents (Class 604/403)
  • Patent number: 6132414
    Abstract: An improved injection device includes containing a pump and pump control circuitry, a handle with a needle for delivering a therapeutic agent to a patient, a cartridge holding the agent and a tube for delivering the agent from the cartridge to the handle. Preferably the cartridge is disposed in a cartridge holder coupled to the tube. A quick disconnect coupling is provided between the cartridge holder and the housing so that it can be easily mounted thereon. The housing further has a receptacle for receiving and storing the tip of the handle.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: October 17, 2000
    Assignee: Spintech, Inc.
    Inventors: Walter Herbst, Chris Quatrochi, Michael Reiter
  • Patent number: 6127009
    Abstract: A dispenser unit has a flexible polymer bag, a joining part (10, 11) and a stiff hard part (20). The joining part has an inner layer (11) welded to the hard part and an outer polymer layer (10) welded to the inner material of the flexible bag. The inner material (30) of the flexible bag and the outer material of the joining part (10) are the same and are joined in such a way that they may be thermally sterilized. A process for manufacturing this dispenser unit has a step of coextrusion of the multilayered bag material, a step of extrusion of the multilayered joining part, and steps for sealing the bag material, sealing the multilayered joining part and sealing the hard part. The dispenser unit can be used for dispensing liquids, in particular aqueous liquids for human or animal medicine or in the food industry.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: October 3, 2000
    Assignee: Pactiv Corporation
    Inventor: Gunther Strassmann
  • Patent number: 6126618
    Abstract: An apparatus for obtaining liquid samples from a fluid flow path is disclosed. The apparatus includes a housing having an access site communicating with the flow path and carrying a piercing member at a location spaced from the access site. The housing allows for translational movement of the piercing member toward the access site and into the flow path from where the sample is removed.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: October 3, 2000
    Assignee: Baxter International Inc.
    Inventor: Daniel F. Bischof
  • Patent number: 6113583
    Abstract: A connector device is disclosed for establishing fluid communication between a diluent container having sidewalls and a drug vial. The connector has a piercing member having a first end and a second end and a central fluid pathway. The piercing member is mounted to the liquid container and has fluid accessing portions hermetically sealed from an outside environment. A vial receiving chamber is associated with the piercing member and is dimensioned to connect to the vial. The vial may be selectively attached to the device without piercing the closure of the vial and without breaching the hermetic seal of the fluid accessing portions of the piercing member. Means are provided for connecting the vial receiving chamber to the liquid container.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: September 5, 2000
    Assignee: Baxter International Inc.
    Inventors: Thomas A. Fowles, Robert J. Weinberg
  • Patent number: 6109315
    Abstract: A dispensing device for dispensing portions of liquid products (5) from a package (1) with flexible walls (4) is provided. A package and a coupling device are provided. The package (1) comprises a first coupling device (6), a dispensing device (3), for dispensing portions of the liquid product (5) from the package (1), comprises a second coupling device (19) and a cassette (2), in which the package (1) can be located, comprises a third coupling device (20). The first coupling device (6) of the package (1) and the third coupling device (20) of the cassette (2) are interconnectable without opening the package (1) and, when said first and third coupling devices (6 and 20) are interconnected, the first coupling device (6) of the package (1) can be connected to the second coupling device (19) of the dispensing device (3) such that the package (1) is opened.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: August 29, 2000
    Assignee: Asept International AB
    Inventor: Leif Einar Stern
  • Patent number: 6105912
    Abstract: A blood reservoir mounting bracket supports alternate sizes of blood reservoir assemblies. The reservoir mounting bracket has a reversible reservoir mounting frame, with mounting pins on one side thereof arranged in a first pattern for the mounting holes of one size of a blood reservoir assembly, and mounting pins on its other side arranged in a second pattern for the mounting holes of a second, different sized blood reservoir assembly. Alternatively, the reservoir mounting bracket has a reservoir mounting frame with retractable pins therein for use in adapting to differently arrayed holes on different sized blood reservoir assemblies. The reservoir mounting bracket further has an oxygenator holder which allows orientation of the oxygenator in a plurality of positions.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: August 22, 2000
    Assignee: Terumo Cardiovascular Systems Corporation
    Inventors: Erin J. Lindsay, Daniel W. Viitala
  • Patent number: 6099512
    Abstract: A drip chamber for an intravenous fluid delivery system includes a housing having an inlet port and an outlet port, the inlet and outlet ports each having an inner diameter, and the housing defining a chamber between the inlet and outlet ports. The housing configured to channel intravenous fluid in a flow path from the inlet port through the chamber and to the outlet port. A member supported in the chamber between the inlet and outlet ports is positioned so that the intravenous fluid flowing through the chamber impinges against the member to reduce the velocity of the intravenous fluid and minimize formation of air bubbles in the intravenous fluid. The inner diameter of the inlet port being substantially equal to or greater than the inner diameter of the outlet port, such that a flow rate of the intravenous fluid exiting the outlet port is substantially equal to or less than a flow rate of the intravenous fluid entering the inlet port.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: August 8, 2000
    Inventor: Hector Urrutia
  • Patent number: 6090091
    Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: July 18, 2000
    Assignee: Baxter International Inc.
    Inventors: Thomas A. Fowles, Robert J. Weinberg, Thomas J. Progar
  • Patent number: 6086574
    Abstract: A fluid delivery system includes a flexible media bag having an outlet spout projecting therefrom. A passageway longitudinally extends through the outlet spout and communicates with the interior of the media bag. A diptube connector is mounted to the outlet spout. The diptube connector includes a stem having a first end with a barb radially projecting out therefrom and an opposing second end with an annular flange radially projecting out therefrom. The flange has an outer diameter greater than the inner diameter of the passageway in the outlet spout. The first end of the diptube connector is received in sealed engagement within the first end of the diptube. The second end of the diptube is passed through the passageway in the outlet spout such that the flange on the diptube connector rests on the outlet spout. The outlet spout having the diptube connector mounted thereon is received in sealed engagement within a delivery tube.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: July 11, 2000
    Assignee: Hyclone Laboratories, Inc.
    Inventors: David C. Carroll, Pat Draper
  • Patent number: 6083584
    Abstract: A container (10) suitable for medical uses comprising a first planar member (18), a second planar member (22), a first seam (24) and a second seam (26). The first planar member (18) is of a multi-layered polymeric material and further comprises a first substrate (38) and a first layer (46). The first layer (46) is disposed on a portion of the first substrate (38) to separately define a first overlap area (58) and an adjacent first peripheral flange (62). The second planar member (22) is of a multi-layered polymeric material. The first seam (24) attaches a portion of the first overlap area (58) to the second planar member (22). The second seam (26) is spaced from the first seam (24) and attaches a portion of the first peripheral flange (62) to the second planar member (22).
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: July 4, 2000
    Assignee: Baxter International Inc.
    Inventors: Sidney T. Smith, Steven H. Giovanetto
  • Patent number: 6077447
    Abstract: A device for producing fibrinogen includes a platen having a surface configured for heat exchange with a container, which is adhered to the platen by device of a vacuum and heat exchange allowing both cooling and heating to occur along the boundary between the container and the platen. The platen is operatively coupled to a device of rocking the platen about a horizontal axis and the container allows scavenging of a cryoprecipitate fibrinogen from the blood product for subsequent utilization.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: June 20, 2000
    Assignee: ThermoGenesis Corp.
    Inventors: Philip H. Coelho, Terry L. Wolf, Curtis D. Mau, Jeffery D. Arnett, Richard F. Huyser
  • Patent number: 6077235
    Abstract: An assembly for collection of a blood sample includes a hydrophobic plastic tube and a non-exudable block or graft copolymer having a hydrophobic domain compatible with and interpenetrated in the matrix of the tube plastic and a hydrophilic domain which provides a hydrophilic interior wall surface to the container. The invention includes a method to make the container.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: June 20, 2000
    Assignee: Becton, Dickinson and Company
    Inventors: Peter Serpentino, Fu-chung Lin, Hariharan Shankar, Theodore S. Weir
  • Patent number: 6071270
    Abstract: The present invention provides a connector device for establishing fluid communication between a first container and a second container. The device has a first sleeve member having a first and a second end, the first sleeve member having at the first end a first attaching member adapted to attach to the first container. The device further has a second sleeve member having a first end and a second end, the second sleeve member being associated with the first sleeve member and movable with respect thereto from an inactivated position to an activated position, the second sleeve member having at the second end a second attaching member adapted to attach the second sleeve member to the second container. First and second piercing members project from one of the first and second sleeve members for providing a fluid flow path from the first container to the second container, and the first and second piercing members are independently hermetically sealed.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: June 6, 2000
    Assignee: Baxter International Inc.
    Inventors: Thomas A. Fowles, Thomas J. Progar, Robert J. Weinberg, Craig A. Fuller
  • Patent number: 6070623
    Abstract: A connecting device (1) between a first receptacle (2) and a second receptacle (4) comprising a muff joint (4a), the device comprising an apparatus (5) for perforating a stopper, including a faucet (6) and a filtering chamber (7) isolated from outside by a filter (8), two independent channels (9, 10) being provided in the perforating apparatus (5) for communicating the inside of the first receptacle (2) with the faucet (6) and the filtering chamber (7) respectively, the device further comprising an element (11) for displacing with guidance the perforating apparatus (5), an element for fastening (13) the skirt (12) on the neck (2a), a plunger (15) mounted in the internal bore (12a) on which the perforating apparatus (5) are fixed, for sliding by simple pressure, and an element (16) for definitively stopping the plunger (15).
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: June 6, 2000
    Assignee: Biodome
    Inventor: Antoine Aneas
  • Patent number: 6060138
    Abstract: Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: May 9, 2000
    Assignee: Pall Corporation
    Inventors: Raleigh A. Carmen, Ronald H. Bauman
  • Patent number: 6053890
    Abstract: A needleless jet injection device including a barrel fitted with a cap at one of the ends thereof. Relative motion of the cap component actuates a setting device operably connected to a precussive member. A cartridge arranged at the other end of the barrel comprises two elements, i.e., a first element forming a container for the active principle, and a second element consisting of a plastic shell enclosing the first element.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: April 25, 2000
    Inventors: Alain Moreau Defarges, Xavier Moreau Defarges
  • Patent number: 6045546
    Abstract: Apparatus and method for collecting, processing, and storing blood components, such as plasma. The method involves collecting the blood component in a flexible storage bag manufactured from ethylene vinyl acetate EVA, having a composition of between about 9% and about 18% vinyl acetate by weight of total EVA co-polymer. The EVA bag is sealed, and the sample is frozen in the bag at a temperature of at least as low as -30.degree. C. to form a substantially solid pellet contained in the storage bag. The bag then is fractured and the pellet is removed in its intact, frozen form. The co-polymer bag may have an inner surface with an etched or embossed pattern of sufficient dimensions to permit removal of the plasma in a frozen state from the storage bag.
    Type: Grant
    Filed: August 16, 1995
    Date of Patent: April 4, 2000
    Assignee: Pall Corporation
    Inventors: James A. Drago, Bruce Kuhlemann, Richard Spielberg
  • Patent number: 6039718
    Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: March 21, 2000
    Assignee: Bracco Research USA
    Inventor: John J. Niedospial, Jr.
  • Patent number: 6033392
    Abstract: A bag for securing an irrigation syringe to an IV pole includes a first sheet of flexible material having four sides, and a second sheet of flexible material having four sides which are sealingly attached to the first sheet along three sides thereof. The unsealed side of the second sheet defines a mouth for accessing the interior of the bag. The interior region is sized for receiving the irrigation syringe therein. A flap which is sealingly attached to the first sheet at the top of the sheet extends over the mouth in such a manner that it closes the mouth of the bag to prevent airborne particulates from entering the bag, thus protecting the syringe. A slot formed in the first sheet is provided for securing the bag to an IV pole. The inner surfaces of the first and second sheets and the flap are treated with anti-microbial material for substantially inhibiting bacteria on the syringe.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: March 7, 2000
    Inventors: John W. Frey, George A. Hird
  • Patent number: 6022344
    Abstract: The present invention relates to a bag for the cryopreservation of blood cells, comprising a joining piece and a shrink tube to connect the bag with a non-PVC tubing. The tubing is resistant to the liquid nitrogen temperature and can be used for RF sealing and sterile docking both before and after cryopreservation.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: February 8, 2000
    Assignee: NPBI International B.V.
    Inventors: Else Johanna Meijer, Mirijam Wilhelmina Suzanna Ter Laak-Ter Beek
  • Patent number: 6020181
    Abstract: The invention provides a method of causing the degradation of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances) by means of a fibrinolytic matrix metalloproteinase, preferably an MMP-3 or MMP-7. The method of the invention can be performed in vitro to provide diagnostic information characterizing fibrin(ogen) and fibrinolytic physiology. The method can also be performed in vivo as a method of thrombolytic therapy in which a fibrinolytic matrix metalloproteinase is administered to a subject to degrade thrombus in situ. The fibrinolytic matrix metalloproteinase can be administered in conjunction with other active agents, preferably with agents having thrombolytic activity to improve thrombolytic and fibrinolytic therapy. The invention further provides compositions containing a fibrinolytic matrix metalloproteinase for the performance of fibrinolytic or thrombolytic procedures.
    Type: Grant
    Filed: May 21, 1997
    Date of Patent: February 1, 2000
    Assignee: New York Blood, Inc.
    Inventor: Alessandra Bini
  • Patent number: 6019752
    Abstract: A fluid vessel which include a drug storing chamber, a capping member for hermetically sealing the mouth portion of the drug storing chamber, and a solvent chamber joined to the bottom of the drug storing chamber, wherein the drug storing chamber is provided with a communication hole at the bottom thereof for communicating with the solvent chamber and includes a protruding piece which hermetically seals the communication hole, protrudes into the drug storing chamber, and is movable so as to open the communication hole, while the capping member has an engaging portion to be engaged with the tip of the protruding piece whereby the protruding piece is moved to open the communication hole by rotation of the capping member. This vessel serves to simplify the manufacturing process and reduces the number of components, is readily disposed of, facilitates mixing the drug with the solvent, and is easy to store and handle in hospitals and other facilities.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: February 1, 2000
    Assignees: Fujisawa Pharmaceutical Co., Ltd., Nissho Corporation
    Inventors: Seizo Sunago, Akira Kagayama, Osamu Takahata, Hitoshi Futagawa, Mitsuo Murakami, Tomohiko Kubo
  • Patent number: 6019750
    Abstract: The present invention provides a septum for sealing an end of a medical connector. The connector has an end to attach to a closure of a container, the closure of the container having a target site, the connector further having a piercing member therein for piercing the target site of the closure. The septum comprises a disk having opposing first and second surfaces, a sheath extending axially from the first surface of the disk, and an annular ridge extending from the second surface of the disk, the annular ridge having a flared distal end, the distal end being dimensioned to form a fluid tight seal with the target area of the closure.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: February 1, 2000
    Assignee: Baxter International Inc.
    Inventors: Thomas A. Fowles, Thomas J. Progar, Robert J. Weinberg, Craig A. Fuller
  • Patent number: 6019770
    Abstract: A versatile endoscopic retrieval bag system comprises a collapsible bag and a cooperating manipulating instrument or grasper. The two layer bag comprises an outer layer waterproof plastic bag and an inner layer mesh plastic bag which is rolled between two sides of a firm plastic rim which includes a hinge or discontinuity at the center and each end of each rim to permit bending of the rim at four points. The limbs of the manipulating instrument fit snugly onto the rim at one end up to the discontinuity. In use, the manipulating instrument is activated causing the rim to assume a substantially square, open configuration with the collapsible bag extending outwardly therefrom within a body cavity to receive various body organs or tissues.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: February 1, 2000
    Inventor: George C. Christoudias
  • Patent number: 6017317
    Abstract: An assembly for collecting blood or other body fluids is provided. The assembly includes an elongate tube having an open end and a closed end. The open end includes threads. An internally threaded plastic cap is mounted to the open end of the tube. The cap includes an axial passage and a resealable member aligned with the axial passage. A gas-impermeable member is bonded to the resealable member and the open end of the tube. Both the resealable member and gas-impermeable member are pierceable by a needle. The cap is removable with the resealable member and the gas-impermeable member as a unit due to the fact that the bond between the gas-impermeable member and the tube is weaker than that between the gas-impermeable member and the resealable member. The cap includes a deflectable portion near its top end to engage the walls of a tube holder, and to function as a shock absorber if the tube is dropped.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: January 25, 2000
    Assignee: Becton Dickinson and Company
    Inventors: C. Mark Newby, Henry F. Miller, Keith E. Schleiffer
  • Patent number: 6012578
    Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10) and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: January 11, 2000
    Assignee: Baxter International Inc.
    Inventor: Michael R. Keilman
  • Patent number: 6001087
    Abstract: An assembly and method for storing and dispensing additives that are used in the preservation, separation or analysis of a blood sample. The assembly comprises a container, a reservoir and a cap wherein the reservoir is a liquid impermeable material.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: December 14, 1999
    Assignee: Becton Dickinson and Company
    Inventor: Robert G. Zurcher
  • Patent number: 5968619
    Abstract: Improved flexible film and tubing for medical products manufactured from a PVC compound, comprising an amount of ultra high molecular weight (UHMW) PVC resin having an inherent viscosity ranging from about 1.25 to about 2.00, most preferably about 1.71, and about 43 to about 57 percent by weight of a medically acceptable plasticizer, most preferably about 53 percent, such as tri (2-ethylhexyl) trimellitate (TOTM).
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: October 19, 1999
    Inventors: Raleigh A. Carmen, Ronald H. Bauman
  • Patent number: 5954958
    Abstract: A method for manufacturing and using a dialysis collection bag, and the dialysis collection bag itself. A collection bag is fabricated with a sterilization tablet therein, having a soluble coating over a sterilization agent. When the collection bag is filled with used dialysis solution at the completion of the dialysis therapy, the soluble coating dissolves over a known period of time such as about 30 minutes. The delayed dissolution allows time to take a specimen sample of the unadulterated used dialysis solution. When the dissolution of the coating is completed, the tablet releases the sterilization agent to sterilize the used dialysis solution, so that pathogens are destroyed to prevent the transmission of disease in the event the collection bag is disposed of improperly.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: September 21, 1999
    Assignee: Fresenius USA, Inc.
    Inventor: Thomas I. Folden
  • Patent number: 5955371
    Abstract: A blood collection device comprising formed additive particles. The additive particles are an improvement over available additive formulations that are powder blended in that the components of the additive particles of the present invention are in each formed particle. The formed additive particles comprise a fluoride salt and an ethylenediaminetetraacetate salt or a heparin salt to consistently minimize glycolysis and coagulation of a blood specimen with low hemolysis.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: September 21, 1999
    Assignee: Becton Dickinson and Company
    Inventors: Tatsuhiko Ikeda, Ajit N. Dastane, Robert Losada
  • Patent number: 5955519
    Abstract: The subject of the present invention is the use of at least one alkyl ester of adipic acid in a polyvinyl chloride (PVC) composition for the production of products made from biocompatible material, in particular blood lines, to increase the resistance of these products to irradiation with penetrating rays.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: September 21, 1999
    Assignee: Hospal AG
    Inventor: Roberto Neri
  • Patent number: 5952069
    Abstract: The present invention is a plastic container coated with a multi-layer barrier coating. The multi-layer barrier coating is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: September 14, 1999
    Assignee: Becton, Dickinson and Company
    Inventors: Yelena G. Tropsha, Christopher J. Knors, Susan L. Burkett, Bryan Soo Wong
  • Patent number: 5947950
    Abstract: A needle removal apparatus, comprises a support member having an elongated track formed therein, a carriage mounted in the track and moveable back and forth on the track, a coupling device mounted on the carriage and adapted for receiving and coupling to a needle hub, a drive for rotating the coupling device and unthreading the needle from the syringe collar upon movement with the guide along the track, and biasing means for normally biasing the carriage to one end of the track.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: September 7, 1999
    Assignee: Med-Safe Systems, Inc.
    Inventors: Randall S. Shillington, David R. Millar, Rex O. Bare
  • Patent number: 5947951
    Abstract: A method and apparatus for automatically transferring a predetermined quantity of a sterile liquid to a vial containing a dry medicament for hydrating the medicament and then transferring the hydrated medicament to a container. To hydrate the medicament, a needle is positioned through a vial septum of the vial and an artificial sensor senses when the needle has been positioned through the vial septum and actuates a pump to transfer a predetermined quantity of sterile liquid into the vial. The needle is then removed from the vial septum and the vial is shaken to mix the liquid and medicament. To transfer the hydrated medicament to a container, another needle is positioned through the vial septum. An artificial sensor senses when the needle has been positioned through the vial septum and actuates the pump to transfer the hydrated medicament to the container.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: September 7, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Jose A. Ortiz, Kenneth J. Sylvester
  • Patent number: 5945004
    Abstract: A method and apparatus for treating waste liquids containing body fluids so as to prevent problems such as nosocomial infection due to such waste liquids containing body fluids discharged from patients under (surgical) operation or treatment, particularly those waste liquids containing blood or an irrigation liquid used to irrigate the body cavity of such patient. The method includes collecting a waste liquid containing body fluids into a container, separating the waste liquid into a supernatant liquor and a flocculate within the container, discharging the supernatant liquor from the container, and disposing of the flocculate remaining in the container together with the container.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: August 31, 1999
    Assignee: Daiken Iki Co., Ltd.
    Inventors: Junichi Ohira, Junichi Yamanaka, Satoru Toyoshima, Koichi Murayama
  • Patent number: 5941867
    Abstract: Sterile solutions containing pharmaceuticals suitable for use in low and micro-gravity environments are prepared with unit dose pharmaceutical dispensers having a pre-measured quantity of medicament. A compressed air reservoir may be activated to rupture the dispenser and positively expel the unit dose into solution. This can be accomplished by inverting a bag containing the pharmaceutical or by operation of a piston which pushes all the pharmaceutical from the dispenser. A robot either places the pharmaceutical dispensers inside a mixing chamber or connects the dispensers to the mixing chamber, which comprises a flexible bag expandable to receive sterile water and pharmaceuticals. The mixing chamber may collapse under cabin pressure to drive prepared solutions from the chamber through a sterilization filter into an intravenous bag or dispensing unit.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: August 24, 1999
    Inventor: Ti Kao
  • Patent number: 5941866
    Abstract: A unitary, flexible container, for containment and delivery of medical fluids, having:a) first and second polymeric sheets superimposed and sealed together at their periphery defining an interior reservoir, the container having a top portion, a mid portion and a bottom portion; the bottom portion terminates in a first angle and a second angle of from about 5.degree. to about 45.degree. each from the center of the bottom portion to a horizontal plane crossing the center of the bottom portion;b) an access member integral with the unitary, flexible container located at the center of the bottom portion allowing filling the flexible container with medical fluids and access to the medical fluids for delivery to a patient; andc) at least one oval shaped rigid reinforcing disc positioned in the mid portion of the interior reservoir to prevent collapse of the walls of the container on each other causing hold up of droplets.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: August 24, 1999
    Assignee: Bracco Research USA
    Inventor: John J. Niedospial, Jr.
  • Patent number: 5931828
    Abstract: A reclosable closure for a vial having a neck portion with a sealing flange surrounding an open end thereof is provided. The reclosable closure comprises a metal shell, having a top portion with an opening defined therethrough, and a depending side wall portion sized to engage the flange of the vial. A plastic top is provided having a top portion which overlies the top portion of the metal shell and surrounds the opening and which has an aperture defined therethrough aligned with the opening. The plastic top has an outer skirt which overlies the depending side wall portion of the metal shell, and an inner wall which depends from the top portion of the plastic top around the aperture. The inner wall has a first portion which extends through the opening, and a second portion which extends outwardly from the first portion to secure the plastic top to the metal shell. A reclosable cover is rotatably attached to the top by an integral hinge for rotation about a hinge axis.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: August 3, 1999
    Assignee: The West Company, Incorporated
    Inventor: Jeffrey W. Durkee
  • Patent number: 5932307
    Abstract: A polymeric tubing having an initial diameter and suitable for connecting to rigid housings including a sidewall defining a fluid pathway and having a longitudinal axis, the sidewall of a polymeric material in an amount by weight within the range of 99.999%-90.0%, and an additive in an amount by weight within the range of 0.001%-10%, and wherein the tubing has been oriented along its longitudinal axis to decrease its diameter to define a oriented diameter.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: August 3, 1999
    Assignee: Baxter International Inc.
    Inventors: Patrick T. Ryan, Chuan Qin, Donna L. Rostron, Birendra K. Lal, Yuanpang S. Ding, Susan R. Mizener, Lecon Woo, Michael T. K. Ling, Martin F. Miller
  • Patent number: 5928744
    Abstract: According to the invention, strong adhesion of the layers to each other and simple formation of a strong and leakproof connection with bags or connectors made from polypropylene or polycarbonate during steam sterilisation is achieved by the first plastic material containing at least one polymer which is dimensionally stable at temperatures of .gtoreq.121.degree. C., while the second plastic material contains at least one polymer which is no longer dimensionally stable at temperatures of .gtoreq.121.degree. C. A layer C) (2) is optionally present, the plastic material of which contains at least one polymer which is dimensionally stable at temperatures of .gtoreq.121.degree. C. The invention can be used for medical purposes, in particular as a fluid line in dialysis, infusion or artificial feeding, primarily in connection with connectors or medical bags.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: July 27, 1999
    Assignee: Fresenius AG
    Inventors: Klaus Heilmann, Thomas Nicola
  • Patent number: 5928935
    Abstract: The present invention comprises a biological specimen container assembly for the safe storage and periodic examination of biological specimens therein, which includes an elongated vial having a primary chamber with a first open end and a second closed end. The second closed end on the vial has a secondary chamber therein of generally rectilinear shape in cross-section. A valve having a first end and a second end, has its second end matable with the first open end of the vial, the valve having an adjustably openable and closable bore extending longitudinally therethrough. A hard cap has a cavity therein which is matable over the first end of the valve. An end cap is matable over the hard cap and the valve, the end cap being arranged to maintain sterility of the end cap, the valve and the first end of the vial.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: July 27, 1999
    Inventors: William Alexander Reuss, Jr., William Charles Mers Kelly, David Young Piteups
  • Patent number: 5925028
    Abstract: Device for the transfusion of blood or hemo-derivatives including: a blood or hemo-derivatives container; a device for the transfusion of blood or hemoderivatives to the patient; and a device for connecting the container to the device for the transfusion; the device for connecting includes a joint formed by two central tubular mutually connectable members, both provided with complementary coding devices, and device for locking the connectable members together.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: July 20, 1999
    Assignee: Diesse di Soster Carmen & C. S.n.C.
    Inventor: Pierluigi Delvigo
  • Patent number: 5925029
    Abstract: A method and apparatus for attaching a connector assembly onto a vial is disclosed. The connector assembly features a protective cap, a collar attachable to the rim of the vial, and a crimp cap for securing the collar to the rim. A vial access device is contained within the collar. One or more ribs are provided adjacent a distal portion of the collar to seal against the stopper obturating the vial. The collar is provided with one or more slits which render the collar flexible in directions radial and axial to the central axis of the vial to compensate for variations in tolerances or dimensions present in the various components. The crimp cap can be supplied preattached to the collar in an uncrimped condition.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: July 20, 1999
    Assignee: Becton, Dickinson and Company
    Inventors: Hubert Jansen, Jean Claude Thibault
  • Patent number: 5919356
    Abstract: A portable device for sampling fluid. The device has a puncture device attached to a housing which has an interior and exterior wall. The housing is in fluid communication with the syringe and contains a filtration device comprised of at least one U-shaped hollow fiber membrane. The device also includes a collection chamber. Also in the device is a sensing device including a further hollow fiber membrane the first and second ends each connected to a first and second plug. Each of the plugs contacts the interior wall of the housing. The further hollow fiber membrane contains a sensing agent. The device is arranged so that a sample is collected through the puncture device and is passed through the filtration device where is it passed through the one or more U-shaped hollow fiber membrane to the collection chamber. From the collection chamber it is passed through the hollow fiber membrane which contains the sensing agent device before being passed to a syringe.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: July 6, 1999
    Assignee: FSM Technologies Ltd.
    Inventor: Robert Gordon Hood
  • Patent number: 5904677
    Abstract: A sterile specimen cup with a self-sealing membrane in the top that allows fluids to be injected into or with drawn from the cup with a syringe. This allows the specimen cup to be fully operated with one hand without removing the cover, thus increasing user safety, and sterility.
    Type: Grant
    Filed: July 13, 1995
    Date of Patent: May 18, 1999
    Inventors: Thomas Hartnett Drummey, Patricia Maureen Drummey
  • Patent number: 5904676
    Abstract: A gasketless seal is formed between a flow tube in a venous reservoir and a rotatable connector telescoped into it, by forming on the connector one or more annular ribs of slightly larger diameter than the inner diameter. When the connector is inserted into the flow tube, the rib is partially crushed against the inner wall of the flow tube and forms a tight, rotatable seal with it.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: May 18, 1999
    Assignee: Medtronic, Inc.
    Inventor: Michael R. Van Driel
  • Patent number: 5902608
    Abstract: Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: May 11, 1999
    Assignees: University of North Carolina at Chapel Hill, East Carolina University
    Inventors: Marjorie S. Read, Robert L. Reddick, Arthur P. Bode
  • Patent number: 5896989
    Abstract: Flexible medical container containing a light-sensitive medical fluid packaged in an overwrap having UV rays barrier properties to prevent degradation of the light-sensitive fluid but allowing observation of the content of the medical fluid and identifying inscription printed on the medical container.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: April 27, 1999
    Assignee: Bracco Research USA
    Inventors: Irene K. Ropiak, John J. Niedospial, Jr., Michelle L. Robinson
  • Patent number: 5897548
    Abstract: A method for reducing foam in a blood substance comprising contacting at least a portion of the blood substance with a contact-generating substrate which comprises an antifoaming agent, wherein the antifoaming agent comprises a triglyceride of one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids or a mixture of triglycerides having one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids, wherein the triglyceride or mixture of triglycerides has a hydrophilic-lipophilic balance of from 5 to 10.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: April 27, 1999
    Assignee: Dideco S.p.A.
    Inventors: Silvio Sacco, Giampero Porro, Stefano Rinaldi, Leopoldo Della Ciana
  • Patent number: RE36331
    Abstract: Solutions which contain L-carnitine and alkanoyl L-carnitine are useful for stabilizing blood for transfusions.
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: October 5, 1999
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Arduino Arduini