Therapeutic Material Introduced Or Removed In Response To A Sensed Body Condition Patents (Class 604/503)
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Patent number: 9480825Abstract: A system for anchoring a distal end of a catheter at a treatment site includes an elongated catheter shaft that is formed with a lumen and two cone shaped balloon membranes. For the system, the proximal and distal ends of the balloon membranes are affixed to an outer surface of the shaft to establish balloons having inflation chambers between the membranes and the shaft. A first membrane portion of a first balloon membrane extends from the distal end of the membrane end to a balloon membrane midsection and a second membrane portion extends from the midsection to the proximal membrane end. To establish the proper shape for the inflated balloon, the second membrane portion is configured to establish a cone angle, ?, (relative to a proximally directed portion of the longitudinal axis) that is less than or equal to ninety degrees (??90 degrees).Type: GrantFiled: May 12, 2014Date of Patent: November 1, 2016Assignee: THE GUY P. CURTIS AND FRANCES L. CURTIS TRUSTInventor: Guy P. Curtis
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Patent number: 9452252Abstract: The invention relates to a method and a device for monitoring a vascular access during an extracorporeal blood treatment. The method and the device according to the invention are based on the monitoring of the difference between the venous pressure measured by a venous pressure sensor and the arterial pressure measured by an arterial pressure sensor (in the extracorporeal blood circuit. According to the method and the device according to the invention, a test function describing disturbances in the extracorporeal blood circuit is determined. Said test function is used to determine a noise-free differential pressure from the measured venous and arterial pressure, said differential pressure being evaluated in an arithmetic and evaluation unit to identify a defective vascular access.Type: GrantFiled: March 24, 2009Date of Patent: September 27, 2016Inventor: Pascal Kopperschmidt
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Patent number: 9402806Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: GrantFiled: June 29, 2012Date of Patent: August 2, 2016Assignee: Rani Therapeutics, LLCInventor: Mir Imran
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Patent number: 9364171Abstract: Systems and methods for autonomous intravenous needle insertion are disclosed herein. In an embodiment, a system for autonomous intravenous insertion include a robot arm, one or more sensors pivotally attached to the robot arm for gathering information about potential insertion sites in a subject arm, a medical device pivotally attached to the robot arm, and a controller in communication with the sensors and the robot arm, wherein the controller receives the information from the sensors about potential insertion sites, and the controller selects a target insertion site and directs the robot arm to insert the medical device into the target insertion site.Type: GrantFiled: December 22, 2011Date of Patent: June 14, 2016Assignee: Veebot Systems, Inc.Inventors: Richard J. Harris, Joseph B. Mygatt, Stuart I. Harris
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Patent number: 9326686Abstract: A system including a sensor and a device coupled to the sensor. The sensor is configured to detect in Animalia tissue (i) a first electromagnetic radiation extinction dominated by absorption of a first wavelength and (ii) a second electromagnetic radiation extinction dominated by scattering of a second wavelength. The device is configured to aid in diagnosing at least one of infiltration and extravasation in the Animalia tissue based on the first and second electromagnetic radiation extinctions detected by the sensor.Type: GrantFiled: July 30, 2013Date of Patent: May 3, 2016Assignee: ivWatch, LLCInventors: Gary P. Warren, Matthew S. Alley, Scott J. Anchell, Javier A. Garriz, William J. Naramore, Garret T. Bonnema
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Patent number: 9289550Abstract: An apparatus for the detection of extravasation of an injection fluid infused into a tissue during an imaging procedure is disclosed. The apparatus includes at least a first source of energy to supply an X-ray or gamma ray imaging energy to tissue in the vicinity of a site and at least a first sensor to measure an energy signal resulting from the energy supplied to the tissue by the first imaging energy source, and circuitry configured to compare the energy signal detected by the first sensor to a baseline measurement and provide an alert that extravasation is occurring.Type: GrantFiled: March 20, 2006Date of Patent: March 22, 2016Assignee: Bayer HealthCare LLCInventors: James E. Dvorsky, Chad E. Bouton, Alan D. Hirschman
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Patent number: 9089305Abstract: Diabetes management apparatus comprising a sensor providing measurements of glucose level in a human or animal; an insulin pump for delivering a dose of insulin to said human or animal; and a processor. The processor is adapted to perform the following steps: receive said measurements of glucose level from said sensor; calculate a insulin dose to be delivered by said insulin pump based on said received measurement; assess the validity of the status of the apparatus; and send a command to said insulin pump to deliver said calculated insulin dose, dependent on said assessing step confirming that the status is valid.Type: GrantFiled: December 8, 2009Date of Patent: July 28, 2015Assignee: CAMBRIDGE ENTERPRISE LIMITEDInventor: Roman Hovorka
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Patent number: 9066712Abstract: A system for treating tissue in a patient includes a body having a cooling fluid supply path and a tissue piercing probe in fluid communication with the cooling fluid supply path. The probe extends distally from the body and is insertable into the tissue through the patient's skin. A cooling fluid source is fluidly coupled with the probe such that when cooling is initiated, cooling fluid flows in the probe thereby cooling the probe and any adjacent tissue. A heater element is in thermal engagement with the cooling fluid source and a power source provides power to the heater element thereby heating the cooling fluid. The power source has sufficient power to heat the cooling fluid to at least a desired temperature but has insufficient power to heat the cooling fluid above a critical temperature which results in rupture of the cooling fluid source.Type: GrantFiled: December 22, 2009Date of Patent: June 30, 2015Assignee: MyoScience, Inc.Inventors: Michael Fourkas, Ronald Williams, Punit Govenji, Byron Reynolds
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Patent number: 9061101Abstract: A method for providing decision-assist to medical staff resuscitating a burn patient includes receiving patient information, calculating an infusion rate, outputting the infusion rate, obtaining a urinary output, calculating a new infusion rate using infusion rate model based constants, and outputting the new infusion rate. In some embodiments, the method includes notifying medical staff when problems arise, displaying information regarding the resuscitation, and setting limits regarding the infusion rates.Type: GrantFiled: November 18, 2013Date of Patent: June 23, 2015Assignees: The Unites States of America as represented by The Secretary of the Army, Board of Regents of the University of Texas SystemInventors: Jose Salinas, George C. Kramer, Leopoldo C. Cancio, Kevin Chung, Elizabeth Mann, Steven E. Wolf, Drew A. Guy
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Publication number: 20150147390Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: ApplicationFiled: January 27, 2015Publication date: May 28, 2015Inventor: Mir Imran
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Publication number: 20150148773Abstract: Embodiments disclosed herein are directed to fluid spraying apparatuses, and related systems and methods. The disclosed fluid spraying apparatuses may be used, for example, to spray a medically suitable fluid on a target region of a living subject such as for treating or removing tissue. In an embodiment, a fluid spraying apparatus includes a target designation unit having a target sensor configured to sense a target region of a living subject, a spray mechanism, and a controller. The spray mechanism includes at least one reservoir configured to hold fluid, and a spraying device operably coupled to the at least one reservoir, the spraying device configured to spray the fluid in the at least one reservoir onto the target region. The controller includes control electrical circuitry operably coupled to the spray mechanism and the target designation unit, and configured to control the spray mechanism responsive to the target sensor sensing the target region.Type: ApplicationFiled: February 2, 2015Publication date: May 28, 2015Inventors: Mahalaxmi Gita Bangera, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Lowell L. Wood, Jr.
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Publication number: 20150141953Abstract: An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.Type: ApplicationFiled: January 26, 2015Publication date: May 21, 2015Inventors: Ramesh Wariar, Baru Maskara, Qi An, Pramodsingh Hirasingh Thakur, Julie A. Thompson
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Patent number: 9033951Abstract: A device for delivering fluid to a user includes a housing, a drive motor assembly in the housing, a force sensor, and an electronics module. The drive motor assembly regulates delivery of fluid by actuating a piston of a fluid reservoir, and the force sensor generates output levels in response to force imparted thereto during, for example, fluid delivery operations. The electronics module processes the output levels of the force sensor to assess the operating health of the force sensor, to check for occlusions in the fluid delivery path, and to monitor the seating status of the fluid reservoir.Type: GrantFiled: January 30, 2013Date of Patent: May 19, 2015Assignee: Medtronic MiniMed, Inc.Inventors: Hsiao-Yu S. Kow, Afshin Bazargan, Ian B. Hanson, Pablo Vazquez, Juan M. Alderete, Jr., Salman Monirabbasi
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Publication number: 20150133888Abstract: Devices, systems, and techniques for programming drug delivery are described. Such techniques may account for diffusion and mixing of drug within the fluid or allow for more flexible programming options. In one example, a method may include determining one or more fluid delivery parameters (e.g., volume, flow rate, or period of time) for a fluid that is a mixture of two other fluids. The determination may be based on one or more fluid delivery parameters of the two other fluids and/or a concentration profile representing the mixing between the two other fluids. In other examples, drug delivery programming may be facilitated by the selection of various patterns and steps of drug delivery. The system may track volume of delivered fluid to maintain desired dosing of the patient.Type: ApplicationFiled: November 10, 2014Publication date: May 14, 2015Inventors: Irfan Z. Ali, Prasanna Anbazhagan, William J. Mitchell, Earle T. Roberts, Touby A. Drew
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Patent number: 9022973Abstract: In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of “cells” containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontrollers) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto.Type: GrantFiled: December 17, 2008Date of Patent: May 5, 2015Assignee: New World Pharmaceuticals, LLCInventors: Frederick A. Sexton, Ian Ivar Suni, Cetin Cetinkaya, Stephanie Schuckers, Eduard Sazonov
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Publication number: 20150119651Abstract: Wireless systems and methods include a plurality of peripheral electronic devices each having a wireless communication system. A processor is configured to establish an association confidence level indicative of a likelihood that a peripheral electronic device is associated to a monitored subject for each peripheral electronic device based on association criteria. Indicators are configured to communicate the association the association confidence level.Type: ApplicationFiled: October 29, 2013Publication date: April 30, 2015Applicant: GENERAL ELECTRIC COMPANYInventor: Matthew George Grubis
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Patent number: 9017307Abstract: A device for delivering fluid to a user includes a housing, a drive motor assembly in the housing, a force sensor, and an electronics module. The drive motor assembly regulates delivery of fluid by actuating a piston of a fluid reservoir, and the force sensor generates output levels in response to force imparted thereto during, for example, fluid delivery operations. The electronics module processes the output levels of the force sensor to assess the operating health of the force sensor, to check for occlusions in the fluid delivery path, and to monitor the seating status of the fluid reservoir.Type: GrantFiled: April 19, 2013Date of Patent: April 28, 2015Assignee: Medtronic MiniMed, Inc.Inventors: Hsiao-Yu S. Kow, Afshin Bazargan, Ian B. Hanson, Pablo Vazquez, Juan M. Alderete, Jr., Salman Monirabbasi
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Publication number: 20150102925Abstract: A method detects a biological condition and detects a change in the biological condition of a mammal. The device determines if the change in the biological condition exceeds a predetermined threshold and sends a signal based at least in part on the determination.Type: ApplicationFiled: June 11, 2014Publication date: April 16, 2015Inventors: Ivo Foldyna, Kenneth J. Stethem
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Patent number: 9005182Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: April 19, 2013Date of Patent: April 14, 2015Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Publication number: 20150100037Abstract: A system for providing animal maintenance includes a housing operable to accommodate an animal, an actuating arm coupled to the housing and to an attachment device, the attachment device is operable to perform one or more animal maintenance tasks, and the actuating arm is operable to apply the attachment device to the animal, a position sensor operable to determine the position of the animal relative to the position sensor, a restraint is operable to restrict the movement of the animal within the housing, and a processor communicatively coupled to the position sensor, the actuating arm, and the attachment device, the processor is operable to receive measurements from the position sensor and, in response to the received measurements, direct the actuating arm to apply the attachment device to the animal.Type: ApplicationFiled: October 8, 2013Publication date: April 9, 2015Inventor: David R. Allsup
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Patent number: 8998877Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: April 19, 2013Date of Patent: April 7, 2015Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Patent number: 8998885Abstract: A system for performing an intraparenchymal drug infusion including a pump device, a delivery tube, a sensor, and a processor. The tube is fluidly coupled to the pump device, establishing an infusate pathway from the pump to an infusate exit port of the delivery tube. The sensor is positioned to sense a parameter indicative of pressure in the infusate pathway. Finally, the processor is programmed to generate information indicative of infusate delivery effectiveness of a drug infusion procedure based upon information from the sensor. In some embodiments, the processor generates a net infusion pressure profile, such as a pressure-time curve, and prompts display of the pressure profile to a neurosurgeon for subsequent evaluation of infusate delivery effectiveness.Type: GrantFiled: September 14, 2010Date of Patent: April 7, 2015Assignee: Medtronic, Inc.Inventors: Brian D. Nelson, Ann M. Gronda, Matthew H. Adams
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Patent number: 8986280Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: April 19, 2013Date of Patent: March 24, 2015Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Patent number: 8983167Abstract: A variation of a method for estimating a quantity of a blood component in a fluid canister includes: within an image of a canister, identifying a reference marker on the canister; selecting an area of the image based on the reference marker; correlating a portion of the selected area with a fluid level within the canister; estimating a volume of fluid within the canister based on the fluid level; extracting a feature from the selected area; correlating the extracted featured with a concentration of a blood component within the canister; and estimating a quantity of the blood component within the canister based on the estimated volume and the concentration of the blood component within the canister.Type: GrantFiled: January 10, 2013Date of Patent: March 17, 2015Assignee: Gauss SurgicalInventors: Siddarth Satish, Ali Zandifar, Kevin J Miller
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Patent number: 8981948Abstract: A connector clip for medical sensors, including a first main body having two main tip contacts in electrical contact with electrical wires connectable to an instrument and a second main body mounted on the first main body and movable with respect to the first main body between an open position and a closed position. Two auxiliary tip contacts and an electric/electronic circuit provided with two connecting leads each electrically connected to one of the two auxiliary tip contacts are positioned in first or second main body. When a disposable sensor tab is correctly located and clamped each of two contacts is in contact with one of the main tip contacts and one of the auxiliary tip contacts and the electric circuit is connected in parallel with an electrical circuit defined by the sensor.Type: GrantFiled: May 29, 2009Date of Patent: March 17, 2015Assignee: Gambro Lundia ABInventors: Bo Olde, Eddie Nilsson, Derek White, Thierry Court, Eric Roussi
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Publication number: 20150073288Abstract: Control of conduction through a heart is described. A lead with a proximal end and a distal end is provided. The distal end of the lead is inserted into a target area. An agent is delivered through the lead to the target area. Delivery of the agent is monitored via a closed loop feedback system.Type: ApplicationFiled: November 12, 2014Publication date: March 12, 2015Inventors: Michael R. Ujhelyi, Daniel C. Sigg
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Publication number: 20150059756Abstract: Systems, methods, and computer-readable media for providing a decision support solution to medical professionals to optimize medical care through data monitoring and feedback treatment are provided herein. In another embodiment, a computer-implemented method for modeling patient outcomes resulting from treatment in a specific medical area includes receiving patient-specific data associated with a patient, determining a plurality of possible patient states under which the patient can be categorized, a current patient state under which the patient can be categorized and determining probabilities of the patient transitioning from any of the possible patient states to every other possible patient state.Type: ApplicationFiled: November 6, 2014Publication date: March 5, 2015Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock
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Publication number: 20150057505Abstract: Methods are disclosed herein for delivering a medicament to a fetus. The method includes administering the medicament from an injector configured to deliver the medicament across an amniotic membrane to amniotic fluid of the fetus. The method includes administering the medicament from a transmembrane patch placed at an amniotic membrane configured to deliver the medicament across the amniotic membrane to amniotic fluid of the fetus.Type: ApplicationFiled: August 22, 2013Publication date: February 26, 2015Inventors: Mahalaxmi Gita Bangera, Roderick A. Hyde
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Publication number: 20150057635Abstract: Methods, computer systems, and computer readable media are provided for transitioning a clinical care room from a first scene to a second scene in order to facilitate completion of a medication-administration process. The first scene in the clinical care room is presented where the clinical care room has one or more zones. The first scene is associated with a first group of setting for components within the one or more zones. An input indicating that the medication-administration process has been initiated is received. Incident to receiving the input, the second scene is provided. The second scene is associated with a second group of settings for the components. The second group of settings is optimized to facilitate completion medication-administration process.Type: ApplicationFiled: October 31, 2014Publication date: February 26, 2015Inventors: STEPHANIE PALMER BECHTEL, MARK NOLTE
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Patent number: 8961492Abstract: Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., from nicotine. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into skin. A dose of agent is delivered from the assembly into skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel agent out of the assembly. During a second period, a second current having a characteristic to attract agent is used to retain agent in the assembly such that delivery of agent into skin is minimized. In particular embodiments, a dose of agent may be delivered on-demand using an input from the patient using an inhalation sensing device which mimics an inhaled form of tobacco.Type: GrantFiled: September 11, 2013Date of Patent: February 24, 2015Assignee: InCube Labs, LLCInventors: Mir Imran, Talat Imran, Mir Hashim
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Patent number: 8961453Abstract: Infusion devices with blockage detection capability and methods of monitoring infusion devices.Type: GrantFiled: March 29, 2012Date of Patent: February 24, 2015Assignee: Medallion Therapeutics, Inc.Inventors: Sam W. Bowman, Scott R. Gibson, Richard E. Purvis, Brian Michael Shelton, Lawrence Eric Ong, John Paul D'Brot
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Patent number: 8956379Abstract: The present invention relates to devices and systems that alter intracranial compliance, cerebral blood flow and/or intracranial pressure pulsatility/waveform by oscillating the contraction and expansion of a compressible composition within the cranial or spinal cavities such that they increase intracranial capacity. The contraction and expansion of the compressible composition in the oscillating compliance devices can be due to an individual's intracranial pressure, the result of the expansion and compression of a reservoir which is mediated by the contractility of the heart or driven by a pump gaited to a biorhythm. The invention also relates to methods for protecting an individual's brain from abnormal arterial pulsations and for altering an individual's cerebral blood flow using the devices and systems of the invention.Type: GrantFiled: January 18, 2008Date of Patent: February 17, 2015Assignee: The Cleveland Clinic FoundationInventors: Mark G. Luciano, Stephen M. Dombrowski
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Patent number: 8957941Abstract: One embodiment is an enhanced power supply including electronic power supply circuitry within a housing. The enhanced power supply further includes one or more sockets operatively associated with the housing providing for the connection of an external apparatus to the enhanced power supply such that the external apparatus may communicate data or another signal through the connection to an output cable. The output cable may to be connected to a device such that both power and at least one signal will be provided to the device through the output cable. Systems featuring an enhanced power supply and methods of providing power and one or more other signals to a device with a reduced number of cables are also disclosed.Type: GrantFiled: April 5, 2013Date of Patent: February 17, 2015Assignee: Biscotti Inc.Inventors: Matthew B. Shoemake, Syed Nadeem Ahmed
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Publication number: 20150045766Abstract: An apparatus for treating the brain, comprises a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the brain, the first fluid delivery device including a first fluid lumen extending to a first outlet port in the distal end to deliver fluids to a first target location and a first microelectrode mounted within the distal end of the first fluid delivery device for movement between an insertion position in which a first distal tip of the first microelectrode is received within the first fluid delivery device and a deployed position in which the first microelectrode extends out of the first fluid delivery device with the first distal tip thereof penetrating the pia mater to a first electrode target position in the cerebral cortex.Type: ApplicationFiled: October 20, 2014Publication date: February 12, 2015Inventors: Nandor LUDVIG, Richard RIZZOLO, Hai M. TANG, Ruben I. KUZNIECKY, Werner K. DOYLE
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Publication number: 20150038940Abstract: The invention relates to an appliance for performing anaesthesia or analgosedation, comprising a dosing device (5) for the intravenous administration of an adjustable dose of at least one anaesthetic to a patient (1), a measuring device (2) for determining the concentration of the at least one anaesthetic in the exhaled air of the patient (1), means (4) for determining the effect of the at least one anaesthetic on the patient (1), preferably in the form of a depth of anaesthesia or depth of analgosedation, and a data processing device (7), which communicates via interfaces with the dosing device (5), the measuring device (2) and the means (4) for determining the effect and which, on the basis of the determined values of the parameters dosage, concentration and effect of the at least one anaesthetic, establishes a pharmacological model individualized to the patient (1) and, using the individualized pharmacological model that is established, calculates an individual dosage, optimized to the patient (1), of theType: ApplicationFiled: March 13, 2013Publication date: February 5, 2015Inventors: Sascha Kreuer, Thomas Volk, Heiko Buchinger, Joerg-Ingo Baumbach
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Publication number: 20150025494Abstract: Disclosed are various methods and devices for facilitating medical and/or procedures that are performed without “general anesthesia,” which is also described in the specification as the state of patient “unconsciousness” resulting from a drug administered by an anesthetist or anesthesiologist. The devices safely and effectively provide and maintain drug infusions that do not push the patient into unconsciousness and/or general anesthesia. Devices according to embodiments of the invention include the use of stored parameters and/or values that correlate to drug delivery during a procedure, and a patient health monitor to measure and send signals regarding a patient health condition to a processor or other computational device.Type: ApplicationFiled: October 3, 2014Publication date: January 22, 2015Applicant: Scott LaboratoriesInventor: Randall S. Hickle
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Publication number: 20150011874Abstract: Various embodiments are described herein for a device and method for an ingestible medical device with a rotatable element. In some described embodiments, the ingestible medical device includes a storage sub-unit with multiple chambers each having an opening for collecting or dispensing substances from the GI tract. The device further comprises a chamber enclosure with an access port. One of the chamber enclosure and the storage sub-unit are rotatable to allow for aligning the access port with a chamber opening. The ingestible medical device includes a sensor for positioning the access port of the chamber enclosure or the storage sub-unit as one of these elements rotates.Type: ApplicationFiled: August 15, 2014Publication date: January 8, 2015Applicant: MICROPHARMA LIMITEDInventors: Yaw Amoako-Tuffour, Mitchell Jones, Satya Prakash
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Publication number: 20150011968Abstract: A video feed of one or more pupils of a patient can be received and processed to determine a raw measure of pupil size of the one or more pupils over time. Based on this raw measure, at least one of a) a depth of anesthesia for the patient, b) an index of cognitive activity for the patient, and c) a degree of perfusion of an anesthetic being administered to the patient to one or both hemispheres of a brain of the patient can be determined such that one or more actions can be caused to be performed. Related systems, methods, and article of manufacture are described.Type: ApplicationFiled: July 2, 2014Publication date: January 8, 2015Inventors: James J. Weatherhead, Sandra Marshall
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Publication number: 20150011969Abstract: The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.Type: ApplicationFiled: September 24, 2014Publication date: January 8, 2015Applicant: BARONOVA, INC.Inventors: Daniel R. BURNETT, Hugh NARCISO, Paul PASPA, David WISER, Stephen MEADE
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Patent number: 8926584Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.Type: GrantFiled: February 19, 2010Date of Patent: January 6, 2015Assignee: The Invention Science Fund I, LLCInventors: Philip A. Eckhoff, Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Patent number: 8926585Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.Type: GrantFiled: March 30, 2012Date of Patent: January 6, 2015Assignee: DexCom, Inc.Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv U. Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
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Publication number: 20150005738Abstract: A method for monitoring the seating of a guide catheter during a catheter procedure includes monitoring at least one parameter of the catheter procedure and determining if the at least one parameter indicates that a guide catheter is out of position. If the at least one parameter indicates the guide catheter is out of position, an alert is displayed and the position of the guide catheter is adjusted. The parameter may be, for example, blood pressure, an ST wave of an electrocardiogram, contrast agent, fluoroscopic images of a region including the distal end of the guide catheter and ultrasound signals.Type: ApplicationFiled: June 25, 2014Publication date: January 1, 2015Inventor: Steven J. Blacker
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Patent number: 8920401Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.Type: GrantFiled: April 30, 2012Date of Patent: December 30, 2014Assignee: DexCom, Inc.Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv U. Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
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Publication number: 20140371709Abstract: A catheter assembly may be provided with a catheter body and an inflatable balloon. The catheter body has a proximal end, a distal end and a balloon inflation lumen. The inflatable balloon is attachable to the distal end of the catheter body. The balloon has an inner surface that at least partially defines an interior volume. The balloon is configured such that the interior volume can be in fluid communication with the inflation lumen of the catheter body to inflate the balloon. The balloon also has a proximal surface and a distal surface. The balloon is provided with a channel that extends through the balloon. The channel is configured to provide fluid communication between the proximal surface of the balloon and the distal surface of the balloon. Other catheter assemblies and methods of use are also disclosed.Type: ApplicationFiled: June 27, 2014Publication date: December 18, 2014Inventors: Michael P. ALLEN, Robert A. BROMMER, Trevor M. HANNON, Robert J. J. DE NEVE
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Publication number: 20140358071Abstract: System and methods are provided for harvesting one or more organs, e.g., a lung from a donor body. In one embodiment, a distal end of a tubular member is introduced into the donor body's vasculature via a percutaneous access site, and the tubular member is manipulated until the distal end of the tubular member is disposed within the thoracic duct. Fluid is removed from the thoracic duct through the tubular member to a location exterior to the patient's body, and one or more organs are removed from the donor body. Optionally, one or more parameters within the thoracic duct or other parameters of the donor body may be monitored and fluid removal may be adjusted to reduce fluid accumulation within the one or more organs.Type: ApplicationFiled: July 28, 2014Publication date: December 4, 2014Inventors: Matthew J. Callaghan, Christian S. Eversull, Stephen A. Leeflang
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Patent number: 8900213Abstract: An apparatus and method for detecting an occlusion in a downstream fluid line of a medical pump in relation to increased pressure in the downstream fluid line between the beginning and the end of each interval of a series of intervals of operation of the pump even if one or more intervals between the first and last intervals does not reflect such an increase in pressure in the downstream fluid line.Type: GrantFiled: June 7, 2012Date of Patent: December 2, 2014Inventors: Brian Pope, Zhan Liu
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Publication number: 20140350512Abstract: Cerebral Catheter devices and methods for use are provided. The catheter devices provided may include an anti-thrombotic agent coating on the exterior surface. The catheter devices may include unique tip configurations to allow improved fluid delivery capabilities. Further, the catheter devices may also or alternatively include one or more sensor devices in communication with a controller that allow automatically adjusting the delivery of a therapeutic fluid, for example a vasodilator, in response to the condition sensed by the catheter device, such as increased pressure. Moreover, the catheter devices may also be used in conjunction with blood flow transducers to detect and timely prevent and treatment vasospasms or other conditions. Methods for preventing and treatment vasospasm, neoplasm, or other pathological conditions while prolonged using the catheter device are also provided.Type: ApplicationFiled: July 15, 2014Publication date: November 27, 2014Inventor: Joe Sam Robinson
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Patent number: 8894628Abstract: Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.Type: GrantFiled: December 6, 2013Date of Patent: November 25, 2014Assignee: Asante Solutions, Inc.Inventors: Mark C. Estes, Deb Ruppert
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Patent number: 8882741Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.Type: GrantFiled: April 30, 2012Date of Patent: November 11, 2014Assignee: DexCom, Inc.Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv U. Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
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Publication number: 20140330244Abstract: Systems, devices, methods, and compositions are disclosed which include an actively-controllable implantable device configured to, for example, capture and/or release biochemical and/or biological cells in a subject.Type: ApplicationFiled: May 2, 2013Publication date: November 6, 2014Inventor: Elwha LLC