Therapeutic Material Introduced Into Or Removed From Musculature Patents (Class 604/511)
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Publication number: 20090171315Abstract: Methods of treating functional disorders of the bladder in mammalian females are disclosed. A therapeutic compound is delivered directly into the trigone of the bladder. The therapeutic may be delivered to the trigone through the vaginal wall. A device for delivering the therapeutic compound is also disclosed. The device may be an array of microneedles connected to a reservoir.Type: ApplicationFiled: September 3, 2008Publication date: July 2, 2009Inventor: Ebrahim Versi
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Publication number: 20090149831Abstract: A system for treating obesity, comprises an injectable compound for intramuscular administration in a pyloric sphincter, the injectable compound including a plurality of microspheres and a fluid carrier in which the microspheres are suspended. The system further comprises an injection device having flexibility sufficient to pass through a working channel of an endoscope into the stomach to an injection location adjacent to the pyloric sphincter, the injection device including a tissue piercing tip and a lumen through which the injectable compound may be delivered.Type: ApplicationFiled: October 21, 2008Publication date: June 11, 2009Inventors: Goldi Kaul, Katie L. Krueger
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Patent number: 7537588Abstract: A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes a primary penetrating member and a secondary penetrating member. The secondary penetrating member includes an injection lumen in fluid communication with a pressurized fluid source. The primary penetrating member penetrates the heart tissue at the injection site in a first direction, and the secondary penetrating member penetrates the heart tissue in a second direction different from the first direction such that fluid leakage from the injection site is reduced and the volume of treated tissue is increased.Type: GrantFiled: July 27, 2005Date of Patent: May 26, 2009Assignee: Boston Scientific Scimed, Inc.Inventors: Maria Palasis, Arthur Rosenthal
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Publication number: 20090131914Abstract: A site marker deployment device includes a housing defining a first portion, an outer cannula at least partially interposed within the first portion and having a proximal end and a distal end defined by an outer cannula aperture, an inner member at least partially interposed within the outer cannula, a first biasing portion, a second biasing portion, wherein the second biasing portion will selectively urge the outer cannula to move proximally relative to the inner member, and a site marker selectively disposed within the outer cannula adjacent the inner member, near the distal end of the outer cannula. The first biasing portion will selectively urge a site marker at least partially within the outer cannula.Type: ApplicationFiled: November 21, 2007Publication date: May 21, 2009Inventor: Brian Zimmer
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Publication number: 20090131908Abstract: Devices and methods are provided for delivering a drug depot at or near the spinal column of a patient. In various embodiments, the drug depot comprises a drug cartridge containing drug pellets for delivery at or near the spinal column of a patient.Type: ApplicationFiled: November 20, 2007Publication date: May 21, 2009Applicant: Warsaw Orthopedic, Inc.Inventor: William F. McKay
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Patent number: 7500970Abstract: A catheter system for injecting therapeutic agents including large molecules into the body. The catheter includes a distensible penetrating element with a distally locating expansion coil and a distally located chamber for holding a therapeutic agent which is to be injected into the body.Type: GrantFiled: April 26, 2004Date of Patent: March 10, 2009Assignee: BioCardia, Inc.Inventor: Peter A. Altman
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Patent number: 7465458Abstract: The present invention provides methods of treating an eye disorder. The methods comprise a step of locally administering a Clostridial toxin to the eye of a patient to treat the disorder. The eye disorder may be associated with an inflammation of the eye, including for example, bacterial conjunctivitis, fungal conjunctivitis, viral conjunctivitis, uveitis, keratic precipitates, macular edema, and inflammation response after intra-ocular lens implantation. The Clostridial toxin may be produced by a Clostridial beratti, a Clostridia butyricum, a Clostridial tetani bacterium and/or a Clostridial botulinum.Type: GrantFiled: April 19, 2007Date of Patent: December 16, 2008Assignee: Allergan, Inc.Inventor: Eric R. First
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Patent number: 7462176Abstract: A device is described which allows simultaneous application of suction or vacuum for evacuation of fat with application of energy to the fat inside an opening in a cannula. A pair of electrodes is situated within the cavity of the cannula just under the surface of cannula tip opening(s) or as part of the walls of such openings. The electrodes are spaced to allow coagulation of fat entering the cannula. Irrigation may be applied in a continuous or discontinuous or intermittent stream within the cannula to cool the tip and facilitate removal of suctioned tissue and prevent buildup of debris on electrodes. A method for using the cannula to remove adipose tissue or fat destroyed by the energy application through the use of suction with mechanical motion of the cannula, with energy application and optionally with the use of irrigation is also disclosed.Type: GrantFiled: July 18, 2005Date of Patent: December 9, 2008Assignee: Starion Instruments CorporationInventor: Lawrence S. Bass
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Publication number: 20080249504Abstract: Instrument port for allowing access to the interior of the heart or other organ while minimizing blood loss.Type: ApplicationFiled: January 8, 2008Publication date: October 9, 2008Inventors: Omar M. Lattouf, Dirk Hoyns, Larry Hall, Amin Rahme
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Publication number: 20080208167Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structural reinforcing agents such as those agents containing aloe-derived pectin. In other embodiments, the structural reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.Type: ApplicationFiled: May 2, 2008Publication date: August 28, 2008Inventors: John Stankus, Eugene T. Michal
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Publication number: 20080125634Abstract: A method and apparatus for analyzing and treating internal tissues and, in particular, tissues affected by myocardial infarct. The apparatus includes a catheterized device integrating an optical probe and treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with myocardial infarct, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering treatments including stem cell and gene therapy, known for having beneficial effects on tissues associated with myocardial infarct. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.Type: ApplicationFiled: June 14, 2007Publication date: May 29, 2008Applicant: CORNOVA, INC.Inventors: S. Eric Ryan, Jing Tang
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Patent number: 6958060Abstract: A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The molecule is first injected into the muscle at one or multiple sites. Immediately or shortly after injection, electrodes are placed flanking the injection site and a specific amount of electrical current is passed through the muscle. The electrical current makes the muscle permeable, thus allowing the molecule to enter the cell. In the case where nucleic acid is injected, the efficiency of transfer permits expression of protein encoded by the nucleic acid in an amount that exhibits systemic biological activity and which generates a robust immune response.Type: GrantFiled: July 14, 2003Date of Patent: October 25, 2005Assignee: Genetronics, Inc.Inventors: Iacob Mathiesen, Terje Lomo
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Patent number: 6918903Abstract: A device is described which allows simultaneous application of suction or vacuum for evacuation of fat with application of energy to the fat inside an opening in a cannula. A pair of electrodes is situated within the cavity of the cannula just under the surface of cannula tip opening(s) or as part of the walls of such openings. The electrodes are spaced to allow coagulation of fat entering the cannula. Irrigation may be applied in a continuous or discontinuous or intermittent stream within the cannula to cool the tip and facilitate removal of suctioned tissue and prevent buildup of debris on electrodes. A method for using the cannula to remove adipose tissue or fat destroyed by the energy application through the use of suction with mechanical motion of the cannula, with energy application and optionally with the use of irrigation is also disclosed.Type: GrantFiled: April 8, 2003Date of Patent: July 19, 2005Assignee: Starion Instrument CorporationInventor: Lawrence S. Bass
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Patent number: 6776991Abstract: A method for treating priapism in a mammal by administration of a botulinum toxin.Type: GrantFiled: June 26, 2002Date of Patent: August 17, 2004Assignee: Allergan, Inc.Inventor: Markus K. Naumann
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Publication number: 20040102759Abstract: A method of treating the intraluminal disease in a coronary artery by injecting therapeutic agents perivascularly into the myocardium near the site of disease.Type: ApplicationFiled: September 24, 2003Publication date: May 27, 2004Applicant: BioCardia, Inc.Inventors: Peter A. Altman, K. David Crockett
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Patent number: 6709427Abstract: The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal.Type: GrantFiled: August 5, 1999Date of Patent: March 23, 2004Assignee: Kensey Nash CorporationInventors: John E. Nash, Douglas G. Evans, David M. Hoganson
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Patent number: 6669662Abstract: A perfusion catheter with a shaft having a lumen and a plurality of ports through the shaft. A rotatable core with a core groove is disposed within the lumen. The plurality of ports can be exposed by retraction of the core. The core can be rotated within the shaft.Type: GrantFiled: December 27, 2000Date of Patent: December 30, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventor: William E. Webler
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Patent number: 6565553Abstract: The invention relates to methods and devices for delivering medicament by jet injection to an injection site in a patient. The method includes inserting a needle into an insertion point, wherein the needle has a length of less than 5 mm and is operatively associated with an orifice in a nozzle assembly in fluid communication with an ampule chamber containing the medicament. The needle extends less than about 5 mm from the nozzle assembly orifice when the medicament is expelled. Next, a force generating mechanism is activated, and a pressure wall member that is operatively associated with the force generating member moves in response to the activation of the force generating mechanism at a speed sufficient to jet inject the medicament from the ampule chamber through the orifice and needle under a pressure of less than about 4000 psi to deliver a substantial portion of the medicament through the needle and past the insertion point to the injection site.Type: GrantFiled: January 31, 2002Date of Patent: May 20, 2003Assignee: Antares Pharma, Inc.Inventors: Peter L. Sadowski, David M. DeBoer, Claude L. Berman, Paul R. Lesch, Jr.
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Patent number: 6544248Abstract: A surgical device and method allows simultaneous application of suction or vacuum to body tissue and application of energy to the body tissue drawn into a cannula. The device may be inserted laparoscopically into the body, and operated to suck body tissue into the cannula, and heat or electrical energy may be applied to the tissue, and irrigation fluid may also be supplied to surrounding tissue to flush debris and cooling the surrounding tissue.Type: GrantFiled: October 8, 1999Date of Patent: April 8, 2003Assignee: Starion Instruments CorporationInventor: Lawrence S. Bass
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Patent number: 6520927Abstract: A method and to treat dysrhythmias of the heart, for example atrial fibrillation, by creating artificial conduction pathways, fields or patterns. These artificial pathways or fields are created by injecting materials having desired electrical properties into the walls of the heart.Type: GrantFiled: January 14, 2000Date of Patent: February 18, 2003Inventor: John D. Unsworth
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Patent number: 6464680Abstract: A method of enhancing cellular absorption of a substance delivered into a target region of a patient's body, comprising: (a) delivering the substance to the target region; and (b) directing vibrational energy to the target region, wherein the vibrational energy is of a type and in an amount sufficient to enhance absorption into cells of the target region.Type: GrantFiled: July 29, 1998Date of Patent: October 15, 2002Assignee: Pharmasonics, Inc.Inventors: Axel Brisken, Robert Zuk, John McKenzie, Jeff Isner, Meno Nassi
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Patent number: 6428528Abstract: A needle assisted jet injector and method for jet injecting medicament are disclosed. In one embodiment of the injector, the needle is retractably located within an injector nozzle assembly. Upon activation of the energy source, a portion of the needle extends past the nozzle assembly and penetrates the outer layer of skin to deliver the medicament via jet injection to a deeper region. After activation, the needle retracts back into the nozzle assembly. In another embodiment, the needle is fixed to the end of the nozzle assembly. In both embodiments, the length of the portion of the needle that penetrates the skin is less than 5 mm.Type: GrantFiled: February 24, 1999Date of Patent: August 6, 2002Assignee: Antares Pharma, Inc.Inventors: Peter L. Sadowski, David M. DcBoer, Claude L. Berman, Paul R. Lesch, Jr.
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Publication number: 20020055702Abstract: Methods and apparatus are disclosed for treating physiological problems, and for providing rapid, efficacious transdermal treatment, for example, of muscle sprains, erectile dysfunction, or baldness, without requiring the use of needles or other invasive interventions. A topical therapeutic agent and ultrasound energy are applied to a tissue surface, e.g., the skin, such that the ultrasound enhances transdermal penetration of the agent. The invention is especially useful in localized delivery of a controlled dosage of a therapeutic agent to the small blood vessels and capillaries beneath the skin's surface.Type: ApplicationFiled: July 13, 1998Publication date: May 9, 2002Inventors: ANTHONY ATALA, MARCELLE MACHLOUF
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Patent number: 6358917Abstract: This invention provides the use of Botulinum toxin (BTX) to cause paralysis of a depressor anguli oris (DAO) musculature in a patient to alleviate downturn at corners of the patient's mouth.Type: GrantFiled: August 24, 1999Date of Patent: March 19, 2002Inventors: Jean D. A. Carruthers, Alastair Carruthers
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Publication number: 20020010456Abstract: A needle assisted jet injector and method for jet injecting medicament are disclosed. In one embodiment of the injector, the needle is retractably located within an injector nozzle assembly. Upon activation of the energy source, a portion of the needle extends past the nozzle assembly and penetrates the outer layer of skin to deliver the medicament via jet injection to a deeper region. After activation, the needle retracts back into the nozzle assembly. In another embodiment, the needle is fixed to the end of the nozzle assembly. In both embodiments, the length of the portion of the needle that penetrates the skin is less than 5 mm.Type: ApplicationFiled: February 24, 1999Publication date: January 24, 2002Inventors: PETER L. SADOWSKI, DAVID M. DCBOER, CLAUDE L. BERMAN, PAUL R. LESCH JR.
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Patent number: 6245052Abstract: Methods, systems, and kits for subcutaneously implanting articles, such as drug inserts and reservoirs. The methods rely on percutaneously forming a tissue tract and radially dilating the tract to a diameter which permits introduction of the article. By fully expanding the lumenal diameter of the tissue tract prior to introduction of the article, damage to the article resulting from passage through a partially expanded tissue tract can be avoided. In the exemplary embodiment, a radially expandable sleeve is first percutaneously introduced to the subcutaneous target site. An assembly of a cannula and dilator is then passed through the sleeve, effecting radial expansion. The dilator is removed and the article is then introduced through a lumen of the cannula.Type: GrantFiled: July 8, 1998Date of Patent: June 12, 2001Assignee: InnerDyne, Inc.Inventors: Michael J. Orth, Mark C. Yang
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Patent number: 6217554Abstract: Apparatus and methods for delivering a therapeutic or diagnostic agent into extravascular tissue surrounding a body passageway is provided comprising a catheter having a sheath, a tubular member, and a plurality of hollow needles on a distal end of the tubular member. The tubular member is selectively movable between delivery position, wherein the plurality of hollow needles are retracted within the sheath, and an extended position, wherein the plurality of hollow needles extend beyond a distal endface of the sheath to pierce and penetrate extravascular tissue. The catheter also includes a balloon for applying pressure to seal puncture wounds created by the hollow needles.Type: GrantFiled: February 12, 1999Date of Patent: April 17, 2001Assignee: PharmaSpec CorporationInventor: Bert Green
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Patent number: 6126654Abstract: An elongated steerable catheter for placement within a heart chamber, organ aperture or other body opening and having at least one center tube with hollow passageway for guiding a laser delivery means or other functional device to selected surfaces of a heart chamber, organ aperture or other body cavity for laser or other treatment thereon, particularly adapted for laser-assisted percutaneous transmyocardial revascularization (TMR), is disclosed herein. The steerable catheter has a handle portion at its proximal end and a controllably deflectable end portion at its distal end. The elongated center tube has a distal end, in the region where a curvature is to be formed, and a shim anchor sleeve is slidably disposed over the center tube. The shim anchor sleeve is attached to the inside wall of the outer jacket and coupled to the distal end of the center tube with a bendable shim member which extends between the distal tip of the steerable catheter and the sleeve over the center tube.Type: GrantFiled: February 24, 1999Date of Patent: October 3, 2000Assignee: Eclipse Surgical Technologies, Inc.Inventors: Jeffrey Giba, Michael Horzewski, James Edward Wilson
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Patent number: 6090097Abstract: A balloon arterial cannula and methods for filtering blood. The devices generally include a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, a means to actuate the structure, and a balloon occluder which typically includes a flexible material enclosing a chamber. The methods generally include the steps of introducing a mesh into a blood vessel to capture embolic material, adjusting the mesh, if necessary, during the course of filtration, inflating the balloon occluder to occlude the vessel upstream of the mesh, and thereafter deflating the balloon occluder and removing the mesh and the captured foreign matter from the blood vessel. Additionally, visualization techniques are used to ensure effective filtration.Type: GrantFiled: January 16, 1998Date of Patent: July 18, 2000Assignee: Embol-X, Inc.Inventors: Denise Barbut, Giovanni Pastrone, Tracy D. Maahs, Ross S. Tsugita
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Patent number: RE39086Abstract: This invention provides the use of Botulinum toxin (BTX) to cause paralysis of a depressor anguli oris (DAO) musculature in a patient to alleviate downturn at corners of the patient's mouth.Type: GrantFiled: March 17, 2004Date of Patent: May 2, 2006Assignee: Allergan, Inc.Inventors: Jean D. A. Carruthers, Alastair Carruthers