Therapeutic Material Introduced Or Removed Through A Piercing Conduit (e.g., Trocar) Inserted Into Body Patents (Class 604/506)
  • Patent number: 10850037
    Abstract: An injector may include a container having a wall with an interior surface defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a sterile container needle that is in fluid communication with the container in a delivery state, but may or may not be in fluid communication with the container in a storage state. Further, the injector may include an actuator that is adapted to move the container needle from the storage state to the delivery state.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 1, 2020
    Assignee: AMGEN INC.
    Inventor: Scott R. Gibson
  • Patent number: 10843213
    Abstract: A fluid management system includes an authentication device and a fluid dispensing meter, and the fluid dispensing meter includes a processor and a memory. The authentication device is configured to provide data to the processor. The processor is configured to recall information from the memory, to compare the information to the data received from the authenticator, and to control a trigger control mechanism between the activated state and the deactivated state based on the comparison.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: November 24, 2020
    Assignee: Graco Minnesota Inc.
    Inventors: Bradley G. Kahler, Mark L. Bauck, Joshua R. Holmstadt, Glenn E. Highland, Benjamin J. Paar, Chad G. Igo
  • Patent number: 10835689
    Abstract: Methods of protecting muscle tissue from heterotopic ossification employ targeted deliveries of a neuromuscular inhibitor. A method of protecting muscle tissue from heterotopic ossification includes identifying a volume of muscle tissue that is susceptible to heterotopic ossification. A first aliquot of a therapeutic dose of a neuromuscular inhibitor is delivered at a first delivery site within the volume of muscle tissue. A second aliquot of the therapeutic dose is delivered at a second delivery site within the volume of muscle tissue. The first and second delivery sites are separated by a distance to distribute the therapeutic dose within the targeted volume of muscle tissue.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: November 17, 2020
    Inventors: Brandon J. Ausk, Steven Bain, Ted S. Gross
  • Patent number: 10828235
    Abstract: A syringe includes a syringe body having a syringe barrel for receiving and administering a medicament, a hollow needle fluidly communicating with the syringe barrel, and a needle adapter disposed on the syringe body. An outer diameter of the needle adapter is wider than an outer diameter of the syringe barrel, and a distal surface of the needle adapter is substantially flat. The needle adapter facilitates a flush alignment of the distal surface of the needle adapter with at least one of a vial stopper and a vial stopper holder of a medicament vial to ensure that a tip of the needle is properly inserted into the vial to aspirate the medicament within the vial.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: November 10, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Amit Limaye, Kevin O'Hara, David Schiff, Jesse Gala
  • Patent number: 10814061
    Abstract: An infusion set is disclosed that includes an inserter including an inserter housing having at least one flexible arm for holding an infusion set in a single axial position prior to insertion of at least a portion of a cannula of the infusion set, the inserter housing having a surface for contacting the patient's skin. The inserter also includes a movable plunger disposed within the inserter housing for releasing the infusion set from the inserter housing, impacting the infusion set, and imparting momentum to the infusion set to insert the cannula into the patient's skin. The inserter additionally includes a biasing element biasing the plunger toward the activated position.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: October 27, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Eric Bene, Russell Cole, Arthur Klotz, Melissa Rosen, Judy Lin Walish, Michel Bruehwiler, Michael Creighton
  • Patent number: 10814116
    Abstract: A hollow needle device includes a main body having a first surface on which hollow acicular bodies are formed and a second surface opposite to the first surface, a main body supporting member having an opening that accommodates the main body and including a drop-out prevention mechanism for holding the main body that has the hollow acicular bodies being protruded from one end of the opening, an injector supporting member disposed detachably in the opening of the main body supporting member, and a liquid-tight structure that establishes liquid tightness between the injector supporting member and an inner surface that defines the opening in the main body supporting member. The injector supporting member has a connection hole to which a protrusion of an injector is detachably connected liquid tightly to guide an injection solution supplied from the injector into the opening via the protrusion of the injector.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: October 27, 2020
    Inventor: Tomoya Sumida
  • Patent number: 10799635
    Abstract: The present disclosure relates to a monitoring unit for a medicament delivery device, where the monitoring unit has a housing, monitoring circuit arranged in the housing, capable of detecting and monitoring functions of the medicament delivery device, releasable holding elements, which releasable holding elements interact with a medicament delivery device for releasably holding the monitoring unit when attached to a medicament delivery device. Locking elements are operably arranged in the monitoring unit to act on the attachment mechanism, and at least one drive element is operably connected to the locking elements wherein, upon activation of the monitoring unit, the at least one drive element causes the locking elements to act on the releasable holding elements, preventing detachment of said monitoring unit from the medicament delivery device.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: October 13, 2020
    Assignee: SHL MEDICAL AG
    Inventors: Daniel Carlsson, Daniel Säll, Nikolaj Hautaviita
  • Patent number: 10780226
    Abstract: A trigger assembly for an automatic medication injection device. The trigger assembly includes an actuator that rotates when shifted axially, and at least one upstanding member extending from a biased drive element of the device toward said actuator which is rotated within the device housing when the actuator is shifted axially. The trigger assembly also includes a track and follower structured and arranged to guide the biased drive element when being rotated within said housing when the actuator shifts axially and to release the biased drive element for axial movement.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: September 22, 2020
    Assignee: Eli Lilly and Company
    Inventors: Nicole Taylor Gonzalez, Gregory Alan Musselman, Lisa Jeanne Nelson
  • Patent number: 10780219
    Abstract: Ambulatory infusion pumps, medicament reservoirs, and medicament sealing assemblies, including a variety of trocar seal assemblies and fill plug seal assemblies, plus related components, as well as component combinations and related methods.
    Type: Grant
    Filed: February 12, 2017
    Date of Patent: September 22, 2020
    Inventors: Roger E. Smith, Tom Xiaobai He
  • Patent number: 10773021
    Abstract: The present invention relates to a shell assembly for a medicament delivery device, which shell assembly comprises at least one first shell section provided with an entry passage and designed such that at least a major part of a medicament delivery device entered through said entry passage is accommodated inside said at least one first shell section, a closure element operably arranged to said at least one first shell section for closing said entry passage, and fixation elements arranged for fixating said medicament delivery device in relation to said at least one first shell section and said closure element.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 15, 2020
    Assignee: SHL MEDICAL AG
    Inventors: Wen-An Chang, Hsueh-Yi Chen, Chia-Hsin Su
  • Patent number: 10758684
    Abstract: A tamper evident assembly for retaining a plunger and piston within a barrel of a syringe including an elongated tether and a cover connected to the tether and concurrently disposed in an operative position on the syringe. A connector assembly adjustably and fixedly interconnects the tether to the cover in the operative position, wherein the cover is connected in covering relation to a discharge port of the syringe concurrently to a proximal end of the tether being connected to the syringe barrel in a removal preventative relation to the piston. Movable adjustment of the tether relative to the connector assembly defines a retaining segment disposed into a taut, fixed length orientation between the proximal end of the tether and the cover, to further define the operative position.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: September 1, 2020
    Inventors: Jonathan J. Vitello, Timothy Brandon Hunt, Robert Banik
  • Patent number: 10751458
    Abstract: A displacement sensing device is configured for a peritoneal dialysis system. The peritoneal dialysis system includes a housing and a syringe. The syringe is disposed on the housing and has a push rod. The displacement sensing device includes a guide rod, a probing module, and a resistance scale. The guide rod is coupled to the push rod, and the probing module is disposed in the housing and is fixed at the guide rod. The resistance scale is disposed at a side of the probing module. The probing module is configured to contact the resistance scale to obtain a resistance value of the resistance scale and determine a displacement magnitude of the push rod. In addition, a peritoneal dialysis system is also mentioned.
    Type: Grant
    Filed: January 14, 2018
    Date of Patent: August 25, 2020
    Assignees: Acer Incorporated, BENEPET CO., LTD.
    Inventors: Chun-Hung Wen, Wei-Chen Lai, Pu-De Ciou, Wen-Pin Chang, Tsung-Hsun Wu, Wen-Shu Lee, Ta-Lun Tan
  • Patent number: 10737021
    Abstract: Disclosed is a medical system having a cartridge and an inserter. The cartridge includes a housing having an interior volume with a first guide within the interior volume. A cradle is disposed within the interior volume and is configured for mounting a medical appliance. The cradle includes a subcutaneous element and an insertion needle. The insertion needle is configured for being actuated to insert the subcutaneous element into a subject. The inserter includes a second guide configured to mate with the housing of the cartridge, and the first guide and second guide are configured to cooperate to guide the inserter into the interior volume along a guiding path defined by the first guide. The inserter is configured to removably attach to the cradle when guided into the interior volume. An insertion assembly is provided for actuating the insertion needle to insert the subcutaneous element into the subject.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: August 11, 2020
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Frank Deck
  • Patent number: 10722646
    Abstract: A cannula insertion device is disclosed. The device includes a needle carriage, a rail device on which the needle carriage is slidable, a yoke having a channel, a linkage connected to the needle carriage and extending into the channel, a torsion spring with one end connected to the linkage, and locking device for locking the torsion spring in tension and maintaining the needle carriage and the linkage in a locked position prior to activation. Upon release of the locking device, the tension of the torsion spring is released, which causes the linkage to move in the channel and slide the needle carriage along the rail device. A catheter carriage may also be provided for actuation by the linkage.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: July 28, 2020
    Inventors: Russell Cole, Alyssa Jackson
  • Patent number: 10722660
    Abstract: There is disclosed a fluid warming system (300) for warming intravenous fluid, comprising: a heater unit (304), including a heating element (314) and at least one temperature sensor; a heat exchanger unit (302), removably attachable to the heater unit (304), which includes an inlet (306) and an outlet (308) through which the fluid can pass, and a controller (316), programmed: to receive at least one temperature measurement (TCI, TCO) from said at least one temperature sensor in the heater unit (304); to compute a fluid flow rate (q), corresponding to the rate of flow of fluid from the inlet (306) to the outlet (308) of the heat exchanger unit (302), in dependence on the amount of electrical power (PH) supplied to the heating element and said at least one temperature measurement (TCI, TCO); and to control the electrical power (PH) supplied to the heating element in dependence on the computed fluid flow rate (q).
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 28, 2020
    Inventor: Robertus Gerardus Van Oudenallen
  • Patent number: 10716926
    Abstract: A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: July 21, 2020
    Assignee: Kindeva Drug Delivery L.P.
    Inventors: Scott A. Burton, Chin-Yee Ng, Michael J. Frits, Richard R. Mathias
  • Patent number: 10709841
    Abstract: An injection device (100) suitable for the delivery of a viscous medicament from a container (10) through a needle (16) disposed at the distal end of the container (10) is disclosed. The device comprises a housing (102), an advancing mechanism (190, 204, 230) operable to move the container (10) relative to the housing from a starting position in which the needle (16) is shrouded and an insertion position in which the needle (16) is exposed, and a stopper drive arrangement operable to move a stopper (22) towards the distal end of the container (10). The stopper drive arrangement comprises a drive body (240) arranged for axial movement with respect to the housing (102), a driveshaft (250) arranged for rotation with respect to the drive body (240), a plunger (202) arranged for axial movement with respect to the drive body (240) to move the stopper (22) upon rotation of the driveshaft (250), and drive means (290) arranged to rotate the driveshaft (250) upon activation of the stopper drive arrangement.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: July 14, 2020
    Assignee: Owen Mumford Limited
    Inventors: Toby Cowe, Matthew Farmer
  • Patent number: 10695509
    Abstract: A negative pressure injection device which includes a suction cup and an inner skirt that encircles an injection port and depends into the interior of the suction cup. An injection member is surrounded by and protrudes below the inner skirt. When air is drawn from the suction cup an epidermis of a patient is drawn into the suction cup until the epidermis comes into contact with the inner skirt and that portion of the injection member protruding below the inner skirt. The inner skirt provides consistent epidermis positioning. The depth of injection is consistently defined by the extent to which the injection member protrudes below the inner skirt.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: June 30, 2020
    Inventors: Alexsandr Kavokin, Nigel Anthony Syrotuck, Mark Sasha Drlik
  • Patent number: 10695312
    Abstract: Disclosed herein are methods of treating disease with a combination of a RXR agonist and a thyroid hormone.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: June 30, 2020
    Assignee: Io Therapeutics, Inc.
    Inventors: Roshantha A. Chandraratna, Martin E. Sanders
  • Patent number: 10661014
    Abstract: An injection device for injecting medicament in a patient comprises a housing configured to house a fluid reservoir that has one of a plurality of volumes of medicament. An injection conduit fluidly coupled to the fluid reservoir defines a fluid pathway from the fluid reservoir to the patient. A firing mechanism is coupled to the fluid reservoir and is configured to expel the medicament from the fluid reservoir through the injection conduit. A volume setting mechanism is coupled to the firing mechanism and is configured to select the one of the plurality of volumes of medicament for the firing mechanism to expel. A dose setting mechanism is configured to select all or a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: May 26, 2020
    Assignee: Antares Pharma, Inc.
    Inventors: Bryan James Sarkinen, Michael Travanty, Patrick Madsen, Andrew Charles Mork
  • Patent number: 10653829
    Abstract: An automatic injector device for delivering a pharmaceutical substance from a cartridge having a protruding edge, positioned in a housing cartridge bay having an opening sized to allow passage of the cartridge; a door to the cartridge bay opening, the door connected to the housing and having an unlatched position and a latched position, the door defining a trajectory between the unlatched position and the latched position; an interference element having a deflected and an inflected orientation, the deflected orientation mechanically interferes with the trajectory of the door; and a contact interface positioned along the cartridge bay and extending up to the protruding edge, the contact interface mechanically couples the deflected and inflected orientation with a sensed contact of the protruding edge, such that when the protruding edge is positioned at the contact interface, the contact interface shifts the interference element into the inflected orientation.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: May 19, 2020
    Inventors: Lior Barchen, Yossi Bar-el
  • Patent number: 10653840
    Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and a housing for such a device. The housing for the drug delivery device comprises an outer housing, a housing insert, which is rotationally constrained to the outer housing and guided axially movable relative to the outer housing, and a cartridge holder. The cartridge holder is attachable to the distal end of the outer housing by at least one groove and at least one lug. The cartridge holder comprises proximally facing ramps and the housing insert comprises corresponding, distally facing ramps. The groove comprises a first sloped portion inclined such that upon a rotational attaching movement, the cartridge holder is moved proximally relative to the outer housing and a second sloped portion inclined such that upon a rotational attaching movement, the cartridge holder is moved distally relative to the outer housing.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: May 19, 2020
    Assignee: Sanofi
    Inventors: Oliver Charles Gazeley, Paul Richard Draper
  • Patent number: 10624762
    Abstract: A bone graft delivery device, including a dilator sheath arranged to be connected to a first transverse process, the dilator sheath having a first window, a ramp guide removably engageable with the dilator sheath and arranged to be connected to the first transverse process, the ramp guide including a second window and a ramp at least partially connected to the second window, a snake sheath, and a snake arranged to feed the snake sheath through the ramp guide and out of the first and second windows toward a second transverse process, the second transverse process being adjacent to the first transverse process.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 21, 2020
    Assignee: Orthorebirth USA
    Inventor: Loubert S. Suddaby
  • Patent number: 10603295
    Abstract: The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss. Such compositions and methods include modulating the epigenetic status of the cell, or rate of protein degradation, to increase expression and/or levels of Atoh1 protein.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: March 31, 2020
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Albert Edge, Judith Kempfle, Dunia Abdul-Aziz
  • Patent number: 10596331
    Abstract: A pharmaceutical injecting device comprises a main body case, a piston, a drive mechanism, a display component, and a controller. The body case has a cartridge holder in which a pharmaceutical syringe is installed. The piston is provided movably with respect to the pharmaceutical syringe that is installed in the cartridge holder. The drive mechanism drives the piston. The controller is electrically connected to the drive mechanism. The display component is connected to the controller. The controller has a display controller. The display controller causes the display component to display a plurality of injection sites and to display at two or more injection sites selectable displays indicating that those injection sites are suitable for injection.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: March 24, 2020
    Inventors: Tsuguhiro Kondo, Seiji Kikuchi, Yasutaka Mukai
  • Patent number: 10589077
    Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: March 17, 2020
    Inventors: Makoto Ogura, Naoki Yamamoto, Takashi Kumon
  • Patent number: 10549074
    Abstract: A tubing assembly having a signal generator placement control device for use in conjunction with electronic catheter guidance systems. The control device facilitates control of the position the guidance systems' signal generator relative to the end of the tubing assembly. The tubing assembly includes a tubular insulator coupled to one end of the control device, and the tubing assembly includes a tubular connector attached to the other end of control device. Also, the tubing assembly includes a catheter attached to the tubular connector and an end member attached to the catheter.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: February 4, 2020
    Assignee: Avent, Inc.
    Inventors: Michael C. Shaughnessy, David K. Platt, Shawn G. Purnell, George A. Nassif, Andrew M. L. Smith
  • Patent number: 10525213
    Abstract: The present invention relates to a medicament delivery device comprising a housing (10, 20, 24, 30), a biased medicament delivery member guard (64) arranged movable in relation to the housing from a proximally extended position to a retracted position, a power pack (87) comprising a plunger rod (88) and a force element (118) arranged to act on said plunger rod (88), which power pack (87) is actuated by a release clip (96) movable in relation to the housing and arranged to said plunger rod (88) for releasibly holding said plunger rod (88) with the force element (118) in a tensioned state; a rotator (82) rotatably arranged inside said housing, which rotator (82) is arranged with a guide element (80) and a medicament delivery member guard lock element (84, 86) on its outer surface, wherein said medicament delivery member guard (64) is arranged with release clip activation elements (112) operably arranged to act on said release clip (96) for releasing said plunger rod, and wherein said medicament delivery member
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: January 7, 2020
    Assignee: SHL MEDICAL AG
    Inventor: Slobodan Stefanov
  • Patent number: 10525192
    Abstract: An insert for a catheter system can include an insert housing which defines a portion of a fluid pathway of the catheter system, a cartridge positioned within the insert housing in a manner to allow fluid flow along the fluid pathway such that fluid contacts the insert during the fluid flow, and an active agent associated with the cartridge. The active agent and the cartridge can be adapted to release active agent from the cartridge during the fluid flow.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: January 7, 2020
    Assignee: Attwill Medical Solutions Steriflow L.P.
    Inventor: Attilio DiFiore
  • Patent number: 10500338
    Abstract: A drug delivery device comprising a drug container extending between a distal end and a proximal end and is capable of being compressed into a single plane; a body extending between proximal and distal ends comprising a hollow space for containing the drug container; and a plunger extending between proximal and distal ends, wherein the distal end of the plunger engages telescopically with the proximal end of the body, wherein the plunger comprises at least one pair of protrusions, wherein the protrusion is capable of compressing the drug container as the plunger moves towards the proximal end of the drug delivery device, by applying a force to the drug container that is perpendicular to the movement of the plunger.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: December 10, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: Annaniy Berenshteyn
  • Patent number: 10493014
    Abstract: A method of treating midface volume deficit in a person is provided. The method generally includes administering a dermal filler, such as a hyaluronic acid based dermal filler, in a sequence of injections that enhance effectiveness and/or duration of the filler. The method may include initially introducing a volume of the filler into at a zygomaticomalar region of the face prior to introducing one or more additional volumes of the filler into the anteromedial region and the submalar region, such that the duration of effectiveness of the treatment is improved, and less filler is required to achieve a desired correction.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: December 3, 2019
    Assignee: ALLERGAN, INC.
    Inventors: Diane K. Murphy, Deepali Paradkar-Mitragotri
  • Patent number: 10478569
    Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: November 19, 2019
    Inventors: Andrew Sealfon, Christopher Erol Ogut
  • Patent number: 10478552
    Abstract: The subject invention provides a drug delivery device for injecting medicament which includes: a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and, an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: November 19, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
  • Patent number: 10478603
    Abstract: Various embodiments of a device, a kit and method for delivering a drug depot are disclosed. The device comprises a housing including a lower body, an upper body, a ring member; and a drug cartridge. The lower body defines a lower body channel. The upper body defines an upper body channel. The drug cartridge defines a depot channel. The ring member is disposed extending upward from an annular step surface of the lower body toward a housing upper end. The ring member includes indicia indicating a characteristic of one or more drug depots in the drug cartridge. A plunger has a push rod for expelling the drug depot through the cannula to a site in the patient. A kit comprises the above components. A method includes assembling the components including selecting a ring member having indicia corresponding to one or more drug depots in the drug cartridge.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: November 19, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Danielle L. Clay, Lloyd Snyder, Jeffrey A. Soucia, Michael Merves, Antonio Belton, Sean Corrigan, Keith Grider, Michael Honsing Lau, Derek Leatzow
  • Patent number: 10471218
    Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), and a piston rod (30) coupled to the housing (10) and to a drive sleeve (40). Rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10). The piston rod (30) is coupled to the housing (10) via a threaded interface (16, 31) with at least two different pitches.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: November 12, 2019
    Assignee: Sanofi
    Inventors: William Geoffrey Arthur Marsh, Anthony Paul Morris, Joseph Butler, Matthew Meredith Jones, Samuel Keir Steel, Richard James Vincent Avery
  • Patent number: 10471210
    Abstract: An auto-injector for administering a dose of a liquid medicament includes a case and a carrier subassembly with a carrier slidably arranged inside the case. The carrier can contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding drive spring load to a syringe stopper. The syringe can jointly, axially translate with the carrier. The drive spring acts between the carrier and the plunger. In an initial state, the plunger is locked to the carrier by a ramped engagement to the carrier and is prevented from rotating out of this engagement depending on a longitudinal position of the carrier in the case. The plunger can be released for rotating out of the ramped engagement when the needle reaches nearly a predefined injection depth on translation of the carrier in the proximal direction for advancing the needle beyond a proximal end of the auto-injector.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: November 12, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Simon Francis Brereton, Thomas Kemp, Rosie Burnell, Matthew Ekman
  • Patent number: 10456146
    Abstract: Disclosed are devices and methods for creating a bore in bone. The devices and methods described involve driving a rotating bit in an axial direction such that both rotation and linear movement are controlled and measurable. The instrument is useful for a surgeon to control and simultaneously measure the travel of the tool into the bone and prevent injury to surrounding structures.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 29, 2019
    Assignee: Smart Medical Devices, Inc.
    Inventor: Wayne Anderson
  • Patent number: 10413663
    Abstract: A valve for a tubing kit used provides a resilient element naturally moving to a closed state to reduce opportunity for inadvertent leakage of medicine and to reduce effort required by healthcare personnel to seal the fluid line. In one embodiment the resilient element is a spring serving to compress the walls of IV tube in the closure and in a second embodiment the resilient element is an elastomeric member that is deformed to provide an opening to allow passage of fluid through the fluid line.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: September 17, 2019
    Assignee: Zyno Medical, LLC
    Inventors: Chao Young Lee, Mei Zhang
  • Patent number: 10398841
    Abstract: An adapter for a syringe has a base portion having an insertion hole configured to surround and engage at least a portion of a barrel of the syringe. The base portion includes a top surface and an opposing bottom surface. At least one projection extends upwardly from the top surface of the base portion. At least one ramp portion is located proximate the at least one projection. A flange portion extends laterally outwardly from the base portion. The flange portion includes a top surface and an opposing bottom surface. The top surface of the base portion extends generally parallel to and is spaced between the top and bottom surfaces of the flange portion.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: September 3, 2019
    Assignee: West Pharmaceutical Services, Inc.
    Inventors: Christopher Evans, Brian Costello, Christopher Gieda
  • Patent number: 10398890
    Abstract: Leads having distal electrodes may be used in application of test stimulation for purposes of implanting a lead having a fixation element distal to an electrode array. The fixation element is proximal the distal electrode. Accordingly, the distal electrode may be advanced beyond a distal end of an introducer while the fixation element may be retained in a retracted configuration by the introducer. If the test signals applied by the distal electrode indicate that the distal electrode is in the desired location of the patient, a series of markings on the lead may be used to facilitate placement of the electrode array at the location previously occupied by the distal electrode; i.e. the desired location of the patient. The electrodes of the electrode array may then be used to provide therapy to the patient.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: September 3, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Martin T. Gerber, Michael D. Baudino
  • Patent number: 10384046
    Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 20, 2019
    Assignee: Corium, Inc.
    Inventors: Danir Bayramov, Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh, Doug Bourne
  • Patent number: 10383743
    Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer and the one or more tensioners are configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: August 20, 2019
    Inventors: John To, John J. Flynn
  • Patent number: 10363372
    Abstract: Plunger systems for expelling a liquid drug from a drug container within a wearable drug delivery device are provided. A rotation system coupled to a plunger rotates the plunger about a central axis of the plunger to overcome a static friction between the plunger and the drug container. After rotating the plunger, a drive system moves the plunger forward into the drug container to expel the liquid drug for delivery to the patient. A collapsible plunger includes a cavity. A radial torsion spring positioned in the cavity can provide an outward radial force on the collapsible plunger. The cavity enables the collapsible plunger to compress radially when entering and passing through a region of a drug container having a relatively narrower width. The radial torsion spring can radially expand the collapsible plunger when entering and passing through a region of the drug container having a relatively wider width.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 30, 2019
    Inventor: David Nazzaro
  • Patent number: 10322030
    Abstract: The infusion cannula system for pars plana vitrectomy includes a port (100) mounted over a sclerotomy on the patient's eye (200) and an infusion cannula assembly (400) adapted for connection to a vitrectomy machine that maintains pressure in the eye during the procedure. The port (100) includes an external cylindrical shell (10) that is kept stationary and an internal hub (14) having an insertion tube (17) extending therefrom. The internal hub (14) is threadable into the cylindrical shell (10) in increments to control the depth of penetration of the insertion tube (17) through the sclerotomy incision into the vitreous cavity. The infusion cannula (25) is introduced into the eye (200) through the insertion tube (17) to the desired depth. The internal hub (14) may have a pointer (15) that points to calibration indicia on the cylindrical shell (10) corresponding to the depth of insertion of the infusion cannula (25).
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: June 18, 2019
    Inventor: Khalid Al Sabti
  • Patent number: 10307532
    Abstract: A device for inserting an infusion cannula, or sensor, into a patient is presented. The device comprises an insertion needle removable within the infusion cannula, a handle connected to the insertion needle, and a needle cover. The needle cover pivotably mounted on the handle is rotatably movable between a first position, i.e., the front of the insertion needle is in the needle cover, and a second position, i.e., the front is exposed. An infusion site interface comprises a body mounted on a pad attached to the patient; an infusion cannula for inserting into the patient that is connected to the body; a cavity within the body fluidly connected to the cannula; and a septum that seals closed the cavity. The septum is penetrable by an insertion needle in the infusion cannula and by a hollow needle of an infusion tubing connector coupled to the infusion site interface.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: June 4, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Allen John Pearson, James Terence Collins, Neil Alexander Pryor
  • Patent number: 10300223
    Abstract: Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 28, 2019
    Assignee: Neomend, Inc.
    Inventor: Peter G. Davis
  • Patent number: 10280394
    Abstract: A device for preparing adipose tissue for transplantation, from lobular fat extracted, for instance, by liposuction. The device comprises at least one washing and separating container (1) having a washing chamber (11) for washing the liposuctioned material, which washing and separating container (1) has at least one inlet (12) and at least one outlet (13) for the liposuctioned material to enter the washing chamber (11) through the inlet (12) and for at least part of said material, the fluid component, to exit said chamber 11 through the outlet 13. The washing and separating container (1) is coupled to stirring means via coupling means (2) for releasably coupling said washing and separating container (1) to said stirring means, drive means being provided for driving said stirring means.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: May 7, 2019
    Inventors: Carlo Ferdinando Maria Tremolada, Antonio Bosetto, Paolo Pirazzoli
  • Patent number: 10265284
    Abstract: The present invention relates to intervertebral disc-related pain, such as low back pain, chronic low back pain, neck-pain, chronic neck pain and coccygodynia. A composition for use in the treatment of intervertebral disc-related pain is provided. The composition comprises lactic acid and has a pH below 4. The composition is administered into a disc space comprising the nucleus pulposus of an intervertebral disc.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 23, 2019
    Inventor: Kjell Olmarker
  • Patent number: 10251997
    Abstract: The present invention relates to an injection device for dispensing of a liquid medicament, the device comprising: a base (10), a medicament reservoir (20) displaceably arranged on the base (10) and containing the liquid medicament (25), an injection needle (30) displaceably arranged relative to the base (10) between a retracted position (30a) and an extended position (30b), a pressure container (40) containing a pressurized fluid (24), a reservoir displacing arrangement (50) coupled with the pressure container (40) to displace the medicament reservoir (20) into a dispensing position (20b), in which the medicament reservoir (20) is in fluid communication with the injection needle (30), a needle displacing arrangement (60) coupled with the pressure container (40) to at least displace the injection needle (30) into the extended position (30b).
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: April 9, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Christian Nessel, Daniel Auernhammer
  • Patent number: 10245376
    Abstract: An assembly including a needle (3) for administering a fluid is presented. The needle (3) comprises a hollow needle body (4) to guide the fluid. The needle body (4) is furthermore formed such that an inlet section (20) of the needle body (4) defines a first flow direction for the fluid and an outlet section (21) of the needle body (4) defines a second flow direction for the fluid, wherein the first flow direction is inclined with respect to the second flow direction.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: April 2, 2019
    Assignee: Sanofi
    Inventors: Michael Bainton, Matthew Jones