Therapeutic Material Introduced Or Removed Through A Piercing Conduit (e.g., Trocar) Inserted Into Body Patents (Class 604/506)
  • Patent number: 10413663
    Abstract: A valve for a tubing kit used provides a resilient element naturally moving to a closed state to reduce opportunity for inadvertent leakage of medicine and to reduce effort required by healthcare personnel to seal the fluid line. In one embodiment the resilient element is a spring serving to compress the walls of IV tube in the closure and in a second embodiment the resilient element is an elastomeric member that is deformed to provide an opening to allow passage of fluid through the fluid line.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: September 17, 2019
    Assignee: Zyno Medical, LLC
    Inventors: Chao Young Lee, Mei Zhang
  • Patent number: 10398890
    Abstract: Leads having distal electrodes may be used in application of test stimulation for purposes of implanting a lead having a fixation element distal to an electrode array. The fixation element is proximal the distal electrode. Accordingly, the distal electrode may be advanced beyond a distal end of an introducer while the fixation element may be retained in a retracted configuration by the introducer. If the test signals applied by the distal electrode indicate that the distal electrode is in the desired location of the patient, a series of markings on the lead may be used to facilitate placement of the electrode array at the location previously occupied by the distal electrode; i.e. the desired location of the patient. The electrodes of the electrode array may then be used to provide therapy to the patient.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: September 3, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Martin T. Gerber, Michael D. Baudino
  • Patent number: 10398841
    Abstract: An adapter for a syringe has a base portion having an insertion hole configured to surround and engage at least a portion of a barrel of the syringe. The base portion includes a top surface and an opposing bottom surface. At least one projection extends upwardly from the top surface of the base portion. At least one ramp portion is located proximate the at least one projection. A flange portion extends laterally outwardly from the base portion. The flange portion includes a top surface and an opposing bottom surface. The top surface of the base portion extends generally parallel to and is spaced between the top and bottom surfaces of the flange portion.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: September 3, 2019
    Assignee: West Pharmaceutical Services, Inc.
    Inventors: Christopher Evans, Brian Costello, Christopher Gieda
  • Patent number: 10383743
    Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer and the one or more tensioners are configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: August 20, 2019
    Assignee: INTEGRITY IMPLANTS INC.
    Inventors: John To, John J. Flynn
  • Patent number: 10384046
    Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 20, 2019
    Assignee: Corium, Inc.
    Inventors: Danir Bayramov, Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh, Doug Bourne
  • Patent number: 10363372
    Abstract: Plunger systems for expelling a liquid drug from a drug container within a wearable drug delivery device are provided. A rotation system coupled to a plunger rotates the plunger about a central axis of the plunger to overcome a static friction between the plunger and the drug container. After rotating the plunger, a drive system moves the plunger forward into the drug container to expel the liquid drug for delivery to the patient. A collapsible plunger includes a cavity. A radial torsion spring positioned in the cavity can provide an outward radial force on the collapsible plunger. The cavity enables the collapsible plunger to compress radially when entering and passing through a region of a drug container having a relatively narrower width. The radial torsion spring can radially expand the collapsible plunger when entering and passing through a region of the drug container having a relatively wider width.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 30, 2019
    Assignee: INSULET CORPORATION
    Inventor: David Nazzaro
  • Patent number: 10322030
    Abstract: The infusion cannula system for pars plana vitrectomy includes a port (100) mounted over a sclerotomy on the patient's eye (200) and an infusion cannula assembly (400) adapted for connection to a vitrectomy machine that maintains pressure in the eye during the procedure. The port (100) includes an external cylindrical shell (10) that is kept stationary and an internal hub (14) having an insertion tube (17) extending therefrom. The internal hub (14) is threadable into the cylindrical shell (10) in increments to control the depth of penetration of the insertion tube (17) through the sclerotomy incision into the vitreous cavity. The infusion cannula (25) is introduced into the eye (200) through the insertion tube (17) to the desired depth. The internal hub (14) may have a pointer (15) that points to calibration indicia on the cylindrical shell (10) corresponding to the depth of insertion of the infusion cannula (25).
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: June 18, 2019
    Inventor: Khalid Al Sabti
  • Patent number: 10307532
    Abstract: A device for inserting an infusion cannula, or sensor, into a patient is presented. The device comprises an insertion needle removable within the infusion cannula, a handle connected to the insertion needle, and a needle cover. The needle cover pivotably mounted on the handle is rotatably movable between a first position, i.e., the front of the insertion needle is in the needle cover, and a second position, i.e., the front is exposed. An infusion site interface comprises a body mounted on a pad attached to the patient; an infusion cannula for inserting into the patient that is connected to the body; a cavity within the body fluidly connected to the cannula; and a septum that seals closed the cavity. The septum is penetrable by an insertion needle in the infusion cannula and by a hollow needle of an infusion tubing connector coupled to the infusion site interface.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: June 4, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Allen John Pearson, James Terence Collins, Neil Alexander Pryor
  • Patent number: 10300223
    Abstract: Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: May 28, 2019
    Assignee: Neomend, Inc.
    Inventor: Peter G. Davis
  • Patent number: 10280394
    Abstract: A device for preparing adipose tissue for transplantation, from lobular fat extracted, for instance, by liposuction. The device comprises at least one washing and separating container (1) having a washing chamber (11) for washing the liposuctioned material, which washing and separating container (1) has at least one inlet (12) and at least one outlet (13) for the liposuctioned material to enter the washing chamber (11) through the inlet (12) and for at least part of said material, the fluid component, to exit said chamber 11 through the outlet 13. The washing and separating container (1) is coupled to stirring means via coupling means (2) for releasably coupling said washing and separating container (1) to said stirring means, drive means being provided for driving said stirring means.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: May 7, 2019
    Assignee: LIPOGEMS INTERNATIONAL S.P.A.
    Inventors: Carlo Ferdinando Maria Tremolada, Antonio Bosetto, Paolo Pirazzoli
  • Patent number: 10265284
    Abstract: The present invention relates to intervertebral disc-related pain, such as low back pain, chronic low back pain, neck-pain, chronic neck pain and coccygodynia. A composition for use in the treatment of intervertebral disc-related pain is provided. The composition comprises lactic acid and has a pH below 4. The composition is administered into a disc space comprising the nucleus pulposus of an intervertebral disc.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 23, 2019
    Assignee: STAYBLE THERAPEUTICS AB
    Inventor: Kjell Olmarker
  • Patent number: 10251997
    Abstract: The present invention relates to an injection device for dispensing of a liquid medicament, the device comprising: a base (10), a medicament reservoir (20) displaceably arranged on the base (10) and containing the liquid medicament (25), an injection needle (30) displaceably arranged relative to the base (10) between a retracted position (30a) and an extended position (30b), a pressure container (40) containing a pressurized fluid (24), a reservoir displacing arrangement (50) coupled with the pressure container (40) to displace the medicament reservoir (20) into a dispensing position (20b), in which the medicament reservoir (20) is in fluid communication with the injection needle (30), a needle displacing arrangement (60) coupled with the pressure container (40) to at least displace the injection needle (30) into the extended position (30b).
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: April 9, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Christian Nessel, Daniel Auernhammer
  • Patent number: 10245376
    Abstract: An assembly including a needle (3) for administering a fluid is presented. The needle (3) comprises a hollow needle body (4) to guide the fluid. The needle body (4) is furthermore formed such that an inlet section (20) of the needle body (4) defines a first flow direction for the fluid and an outlet section (21) of the needle body (4) defines a second flow direction for the fluid, wherein the first flow direction is inclined with respect to the second flow direction.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: April 2, 2019
    Assignee: Sanofi
    Inventors: Michael Bainton, Matthew Jones
  • Patent number: 10232125
    Abstract: An autoinjector includes a case, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case, a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier, and a trigger button operably coupled to the carrier. The case includes a rib. The needle shroud is movable between a first extended position, a retracted position, and a locked second extended position. The carrier is adapted to hold a medicament container and movable from a first axial position to a second axial position relative to the case. The carrier abuts the rib in the first axial position and the needle shroud is in the first extended position and disengages the rib when the needle shroud is in the retracted position and the trigger button is pressed to advance the carrier to the second axial position.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: March 19, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Thomas Kemp
  • Patent number: 10226582
    Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament comprising a clicker arrangement. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) coupled to the dose selector (80) and arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), a piston rod (30) coupled to the housing (10) and to a drive sleeve (40) such that rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10), a clutch (120) arranged between the number sleeve (60) and the drive sleeve (40), and a dispense clicker comprising a flexible arm (123) and a toothed profile (75). The device further comprises a button (70) operable to effect dose dispensing.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 12, 2019
    Assignee: Sanofi
    Inventors: William Marsh, Anthony Paul Morris, Joseph Butler, Matthew Jones, Samuel Keir Steel, Richard James Vincent Avery
  • Patent number: 10220154
    Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), a piston rod (30) coupled to the housing (10) and to a drive sleeve (40) such that rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10) and a clutch mechanism arranged between the number sleeve (60) and the drive sleeve (40).
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 5, 2019
    Assignee: Sanofi
    Inventors: William Marsh, Anthony Paul Morris, Joseph Butler, Matthew Jones, Samuel Steel, Richard James Vincent Avery
  • Patent number: 10195356
    Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device includes a cartridge containing liquid, a dosing element, which rotates during dose selecting, a last dose nut coupled to the dosing element during dose selecting such that rotation of the dosing element causes an axial movement of the last dose nut, and a stop element, which is provided on the dosing element and which blocks further movement of the last dose nut, if a dose is selected corresponding to the amount of liquid left in the cartridge. The device further includes a last dose sleeve rotationally coupled to the dosing element during dose selecting and rotationally decoupled from the dosing element during dose dispensing.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Karl Hewson, Stuart Milne, Mark Pawulski
  • Patent number: 10188804
    Abstract: A needle guard device mountable to a pre-filled syringe in its ready-to-fill state. The device includes a lock collar and a device shield biased to move relative to the lock collar. The lock collar interfaces with the syringe neck to attach the device to the syringe. With the removal of a needle shield assembly comprising rigid and soft needle shields, the lock collar and device shield are free to move proximally along the syringe neck and interact with a syringe step down area to activate the device. As the device moves proximally, retention arms of the device shield interact with the syringe step down, causing the arms to deflect radially outwards to disengage from the lock collar triggering the device shield to move from a first position to a second position.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: January 29, 2019
    Assignee: Safety Syringes, Inc.
    Inventors: Ryan Schoonmaker, Dustin Hahn
  • Patent number: 10159807
    Abstract: A pen injector apparatus is disclosed for use with a cartridge to deliver a plurality of single metered doses therefrom. The injector apparatus includes a body arranged to provide a conduit which, in use, provides a fluid communication path between the cartridge and a delivery needle and a mechanism arranged to expel therapeutic material from the cartridge. The mechanism is arranged to draw therapeutic material from the cartridge into the conduit by negative pressure and discharge a metered dose from the conduit via the delivery needle.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: December 25, 2018
    Assignee: OWEN MUMFORD LIMITED
    Inventor: Toby Cowe
  • Patent number: 10136907
    Abstract: Devices, kits, and methods of treatment are described. More particularly, methods of treating tissue of a passage wall defining a bodily passage, such as a sinus cavity, airway, or sinus passage are described. An exemplary method utilizes an elongate member having an elongate member proximal end, elongate member distal end, and an elongate member body that defines a curve.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: November 27, 2018
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: Darin Schaeffer, Daniel Dalenberg
  • Patent number: 10137255
    Abstract: An autoinjector includes a case having a rib, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case and adapted to hold a medicament container, and a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier. The needle shroud is movable between a first extended position, a retracted position and a locked second extended position. The carrier is movable from a first axial position to a second axial position relative to the case. The collar abuts the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar disengages the rib when the needle shroud is in the retracted position and the carrier is in the second axial position.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: November 27, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Thomas Kemp
  • Patent number: 10137256
    Abstract: An autoinjector includes a case adapted to hold a medicament container, a needle shroud telescopically coupled to the case, and a plunger slidably disposed in the case. The needle shroud is movable between a first extended position, a retracted position, and a second extended position relative to the case. The plunger is movable between a proximal position, an intermediate position, and a distal position relative to the case. When the plunger is in the intermediate position and the needle shroud is in the retracted position, the plunger abuts the case to prevent the needle shroud from returning to the extended position. When the plunger is in the distal position and the needle shroud is in the second extended position, the plunger abuts the case to prevent the needle shroud from returning to the retracted position.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: November 27, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Stefan Taal, Thomas Kemp
  • Patent number: 10085649
    Abstract: Devices as described herein for localizing an intracerebral hematoma or blood mass in brain tissue include a cannula and one or more sensor wires operably connected between a glucose meter and one or more glucose sensors for determining the location and margins of an intracerebral blood mass.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: October 2, 2018
    Assignee: Rebound Therapeutics Corporation
    Inventors: Jeffrey J. Valko, Michael R. Henson
  • Patent number: 10086133
    Abstract: A set connector assembly for a fluid infusion device is provided. The set connector assembly includes a connector having a body. The body defines a graspable portion and a coupling portion, and the coupling portion is to be received within a portion of the fluid infusion device. The graspable portion has at least one locking tab to lock the connector to the fluid infusion device, and the graspable portion is movable relative to the body to move the connector between a first, locked position and a second, unlocked position relative to the fluid infusion device.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: October 2, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Jacob E. Pananen, Mitchell T. Johnson, Ella Isabella F. Ella
  • Patent number: 10058314
    Abstract: A device having a plurality of anchors configured to be driven into a tissue, and a closure element extending between the anchors and configured to urge the anchors toward each other, closing a wound and complying with motion of the tissue.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: August 28, 2018
    Assignee: Micro Interventional Devices, Inc.
    Inventors: Michael P. Whitman, Peter Datcuk
  • Patent number: 10022528
    Abstract: A self expanding cannula with improved drainage properties based upon its greater length is provided, along with methods of using the cannula in cardiopulmonary bypass.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: July 17, 2018
    Assignee: Coraflo Ltd.
    Inventor: Ludwig K. Von Segesser
  • Patent number: 10004485
    Abstract: A surgical instrument for dispensing a fluid includes a housing and a dispensing shaft. The surgical instrument further includes a dispensing assembly connected to the housing, which includes a dispensing chamber for holding the fluid before it is dispensed. A container is included in which the fluid is stored before the surgical instrument is used. A transfer assembly is included and is connected to the housing which is operable to open the container and transfer the fluid from the opened container to the dispensing chamber before the dispensing assembly is operated.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: June 26, 2018
    Assignee: Surgical Innovations Limited
    Inventors: Vhairi Maxwell, Keir Ridler
  • Patent number: 9999411
    Abstract: A vascular closure device, having an insertion sheath and a vascular closure implant positioned at least partially in the insertion sheath. The vascular closure implant may have an anchor element, the anchor element including an expandable material, a first puncture contact portion, a bend portion connected to the first puncture contact portion, the bend portion including a bend, and a second puncture contact portion connected to the bend portion. The vascular closure implant may also include a plug element coupled to the bend portion of the anchor element. The anchor element may be formed of an expandable material having the same or a different expansion rate than a material forming the plug element. The vascular closure device may additionally include a locator tube having a vessel locator positioned at least partially in the locator tube. The vessel locator may also have an elongated member that includes a superelastic material.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: June 19, 2018
    Assignee: St. Jude Medical Puerto Rico LLC
    Inventor: JyueBoon Lim
  • Patent number: 9987629
    Abstract: The various embodiments described herein relate to fabricating and using open microfluidic networks according to methods, systems, and devices that can be used in applications ranging from home-testing, diagnosis, and research laboratories. Open microfluidic networks allow the input, handling, and extraction of fluids or components of the fluid into or out of the open microfluidic network. Fluids can be inserted into an open microfluidic channel by using open sections of the open microfluidic network. Passive valves can be created in the microfluidic network, allowing the creation of logic circuits and conditional flow and volume valves. The fluid can be presented via the microfluidic network to diagnostic and analysis components. Fluids and components of the fluid can be extracted from the open microfluidic network via functional open sections that are easily interfaced with other microfluidic networks or common laboratory tools.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: June 5, 2018
    Assignee: Tasso, Inc.
    Inventors: Erwin Berthier, Ben Casavant, Ben Moga
  • Patent number: 9981087
    Abstract: Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier can have at least one opening and at least one pair of legs defining at least a portion of the at least one opening.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 29, 2018
    Assignee: AbbVie Inc.
    Inventors: Sherwin S. Shang, Joseph F. Julian, Chuan Li, Eduard N. Tsvirko, Edwin Chim, Shubha Chethan Somashekar, Esra Ozdaryal
  • Patent number: 9962489
    Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: May 8, 2018
    Assignee: TRUE CONCEPTS MEDICAL TECHNOLOGIES, LLC
    Inventor: Michael Hopkins
  • Patent number: 9956343
    Abstract: The pharmaceutical injection device of the present invention comprises a cartridge holder, a main case, a piston, a motor, an opening component, an open/closed detection switch, and a controller. The motor drives the piston in either an insertion direction in which the piston is inserted into a pharmaceutical cartridge, or a pull-out direction in which the piston is pulled out of the pharmaceutical cartridge. The opening component opens the cartridge holder in conjunction with the movement of the piston in the pull-out direction. The open/closed detection switch detects whether the cartridge holder is open or closed. When the open/closed detection switch detects that the cartridge holder is open, the controller controls the motor so as to stop the piston.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: May 1, 2018
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Kenji Murakami, Masato Kagiyama, Tooru Aoki, Yoshihiro Kataoka, Takahiko Tanida, Hiroshi Suzuki
  • Patent number: 9943649
    Abstract: Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel between a first end and a second end. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier can be substantially transparent. The syringe carrier can have first and second legs and an extension disposed therebetween, and at least a portion of the extension can be configured to align with the window and the reservoir when the syringe carrier is in the first position.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 17, 2018
    Assignee: AbbVie Inc.
    Inventors: Sherwin Shang, Eduard Tsvirko, Edwin Chim, Shubha Chethan Somashekar, Esra Ozdaryal, Joseph F. Julian, Chuan Li
  • Patent number: 9940440
    Abstract: A total dose of a therapeutic agent to be delivered to a patient by an infusion device over a total period of time is automatically divided into a plurality of unit doses to be delivered to the patient over a plurality of unit periods of time. The infusion device is automatically programmed to deliver one of the unit doses of the therapeutic agent to the patient over its respective unit period of time, after which the one unit dose is delivered, and a determination is made of whether an error occurred in delivering the one unit dose to the patient. Delivery of the total dose of the therapeutic agent to the patient may include iteratively automatically programming the infusion device to deliver successive unit doses upon determining that no error occurred in delivering a previous unit dose to the patient. Accordingly, the risk of improperly dosing the patient with the therapeutic agent in an event of a software or hardware anomaly within the infusion device is prevented or reduced.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: April 10, 2018
    Assignee: Medtronic, Inc.
    Inventors: Irfan Z. Ali, Donald L. Villalta, Scott A. Sarkinen
  • Patent number: 9913943
    Abstract: A trigger assembly for an automatic injection device which by its operation releases a biased element of the device for movement. The trigger assembly includes a button pressable by a user, and a lock member. Prior to the button being plunged, a blocking element on the button is abutted by a button-engaging surface of the lock member to prevent lock member rotation, thereby allowing an engagement surface on the lock member to remain in engagement with an engagement surface of the biased element so as to restrain motion of the biased element. When the button is plunged, the blocking surface moves clear of the button-engaging surface to allow the lock member to rotate, during which rotation the engagement surfaces disengage to release the biased element for movement.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: March 13, 2018
    Assignee: Eli Lilly and Company
    Inventors: Jesse Arnold Fourt, Bradley James Simpson
  • Patent number: 9901684
    Abstract: A drug delivery device is provided for delivering a drug to a target tissue site. The drug delivery device comprises a body comprising a proximal end and a distal end and a chamber disposed therebetween. An upper portion is disposed about the proximal end of the body. A retaining member is disposed within a wall of the body and engageable with the chamber and a plunger is configured for disposal within the upper portion and the chamber. The upper portion is movable about the proximal end of the body to open the chamber such that the plunger is disposed within a passageway defined within the chamber, and movement of the plunger in a distal direction pushes the retaining member such that the drug moves out of the body. Methods are also disclosed.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: February 27, 2018
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Danielle L. Clay, Jeffrey C. Marx
  • Patent number: 9889277
    Abstract: A tubing assembly having a signal generator placement control device for use in conjunction with electronic catheter guidance systems. The control device facilitates control of the position the guidance systems' signal generator relative to the end of the tubing assembly. The tubing assembly includes a tubular insulator coupled to one end of the control device, and the tubing assembly includes a tubular connector attached to the other end of control device. Also, the tubing assembly includes a catheter attached to the tubular connector and an end member attached to the catheter.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 13, 2018
    Assignee: Avent, Inc.
    Inventors: Michael C. Shaughnessy, David K. Platt, Shawn G. Purnell, George A. Nassif, Andrew M. L. Smith
  • Patent number: 9883953
    Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer and the one or more tensioners are configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: February 6, 2018
    Assignee: INTEGRITY IMPLANTS INC.
    Inventors: John To, John J. Flynn
  • Patent number: 9833561
    Abstract: A system, method or apparatus to detect abnormalities in delivery of a fluid may include an infusion apparatus that is controllable to cause one or more perturbations in a fluid flow (e.g., each of the one or more perturbations in the fluid flow may result in a measurable perturbed force response). A force signal representative of the perturbed force response may be used to determine an integrated perturbed force response value (e.g., using integration of the force signal over a perturbation time period; the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force). A ratio between the integrated perturbed force response value and a normalizing value (e.g., based at least on a maximum perturbation force of the perturbed force response) may be used to determine if fluid flow is occluded.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: December 5, 2017
    Assignee: Gambro Lundia AB
    Inventors: Joshua Chambers, John O'Mahony
  • Patent number: 9750885
    Abstract: Plunger sub-assemblies for automatic injectors include a plunger outer having one or more engagement prongs, a plunger inner having one or more engagement slots which correspond with the engagement prongs of the plunger outer, and a retraction biasing member. The retraction biasing member is retained in a first energized state between the plunger outer and plunger inner when the engagement prongs of the plunger outer are releasably engaged with the engagement slots of the plunger inner. The one or more engagement prongs are capable of flexing substantially radially to release from engagement with the engagement slots of the plunger inner to permit the retraction biasing member to expand from the first energized state to a second expanded state. An automatic injector having a plunger sub-assembly includes a housing, an activation mechanism, and a plunger sub-assembly at least partially mounted within a syringe cartridge having a needle assembly.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: September 5, 2017
    Assignee: UNL Holdings LLC
    Inventors: Philip A. Weaver, Katlin M. Lumme
  • Patent number: 9694142
    Abstract: A device for percutaneous delivery of therapeutic agents includes a head, a wheel rotably mounted on the head, the wheel having an axis of rotation and an outer surface, a plurality of needles disposed upon the outer surface, each needle having a tip projecting away from the axis of rotation of the wheel, and a reservoir mounted on the body, the reservoir containing a fluid, the reservoir having an opening near to the wheel such that the fluid is disposed on the wheel through the opening.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: July 4, 2017
    Inventor: Maria Banar
  • Patent number: 9687612
    Abstract: A dose setting mechanism that prevents dispensing of a drug when an incorrect cartridge assembly is attached to the dose setting mechanism. Dispense of a drug may be allowed by preventing rotation of a spindle nut of a drug delivery device, and dispense of a drug may be prevented by not preventing rotation of the spindle nut. Preventing dispense of a drug may be accomplished by preventing rotation of the spindle when an incorrect cartridge assembly is inserted. Preventing dispense of a drug may be accomplished by preventing the spindle from applying an axial force on the cartridge when an incorrect cartridge assembly is inserted.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: June 27, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Richard James Vincent Avery, Paul Richard Draper, Aled Meredydd James
  • Patent number: 9675447
    Abstract: A method to treat glottic insufficiency includes creating a window in a thyroid cartilage and inserting an implant through the window and into a paraglottic space. The implant includes a balloon with a port connector and a band comprising a proximate end attached to a portion of the balloon. The method further includes securing the band to a thyroarytenoid muscle complex and inflating the balloon to pull on the band, which in turn pulls on the thyroarytenoid muscle, which in turn rotates an arytenoids cartilage to medialize and tighten a vocal cord.
    Type: Grant
    Filed: March 15, 2015
    Date of Patent: June 13, 2017
    Assignee: APREVENT MEDICAL INC.
    Inventors: Guan-Min Ho, Yenyu Chen, Chia-Yuan Chang
  • Patent number: 9664926
    Abstract: A contact lens for cornea-correction crosslinking made of an ultraviolet transmitting material includes, on a cornea contact side, a pressing region projecting in a convex curved-surface shape at a position corresponding to the center of a corneal dome to be pressed and a relief region constituted by an annular concave portion in a circular arc shape, encircling the outer periphery of the pressing region. The contact lens corrects at least naked eye vision or keratoconus cornea by pressing both regions to the cornea and changing its shape. The contact lens includes a reservoir portion outside the pressing region in a lens thickness direction for a riboflavin solution, a communication hole communicating the reservoir portion inside with the pressing region, and an operation-side electrode having the same polarity as that of the riboflavin solution. The mounted contact lens allows riboflavin solution infiltration into corneal tissue by iontophoresis and ultra-violet ray irradiation.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: May 30, 2017
    Inventor: Iwane Mitsui
  • Patent number: 9656017
    Abstract: Devices that include multi-reservoir infusion devices and systems for dispensing compositions for the treatment of subjects with an amylin agonist (e.g., the amylin agonist analog, pramlintide), wherein amylin agonists are administered in certain differential bolus and basal ratios to an administered insulin, as well as methods, compositions, and kits and articles of manufacture comprising said compositions for use in the treatment of responsive patients with an amylin and an insulin in ratios thereof that are distinct for bolus and basal administration.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 23, 2017
    Inventor: Howard E. Greene
  • Patent number: 9616214
    Abstract: A luer connection device is disclosed having a housing including a side wall having an inside surface defining a lumen with a central axis, a proximal end, and a distal end including a male luer tip having a central flow diverter extending outwardly from the central axis of the lumen to direct a fluid to a circumferential dead space distal to the male luer tip. A luer connection device is also disclosed having a flow expansion channel disposed in the lumen tapering outward from the wall of tubular housing and partially extending along a longitudinal axis from the tip opening toward the base opening for increasing mixing and flow through a circumferential dead space in the fluid path distal to the male luer tip.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: April 11, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Marty L. Stout, Jonathan Karl Burkholz, S. Ray Isaacson
  • Patent number: 9592348
    Abstract: An assembly for a drug delivery device, and a drug delivery device, are proposed with a housing having proximal and distal ends. A dose member is displaceable proximally with respect to the housing for setting of a dose of a drug. A clutch member is displaceable proximally with respect to the housing when setting the dose. A stop member is configured to define a clutch stop position for the proximal displacement of the clutch member with respect to the housing, the clutch member, when in the clutch stop position, is prevented from further displacement proximally with respect to the housing, and the clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member proximally with respect to the housing during setting of the dose.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: March 14, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Strehl, Udo Leuschner, Norbert Besenhardt
  • Patent number: 9579462
    Abstract: Needleless injection device components, systems, and methods that involve features including an elongate shaft that has a working shaft comprising a working shaft proximal end, a working shaft distal end, and a working lumen extending between the working shaft proximal end and the working shaft distal end, an injection shaft including an injection shaft proximal end, an injection shaft distal end, and a needless injection orifice disposed through the sidewall at the injection shaft distal end, the injection shaft moveably disposed within the working lumen, and a tissue tensioner secured to the injection shaft at the injection shaft distal end and moveable relative to the working lumen, the tissue tensioner having an expandable surface capable of exhibiting an expanded state and a non-expanded state, the tissue tensioner in the expanded state being capable of tensioning luminal tissue for injection by the needless injection orifice.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: February 28, 2017
    Assignee: Astora Women's Health Holdings, LLC
    Inventor: Justin M. Crank
  • Patent number: 9572800
    Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: February 21, 2017
    Assignee: CLEARSIDE BIOMEDICAL, INC.
    Inventors: Vladimir Zarnitsyn, Samirkumar Patel, Daniel White, Glenn Noronha, Brian Burke, Jennifer Kissner
  • Patent number: 9526884
    Abstract: Disclosed are biocompatible, dissolving microneedle structures with enhanced mechanical strength. More particularly, the present disclosure relates to microneedles containing nanomaterials. Also disclosed are methods of producing such microneedle structures, as well as methods for using them to deliver drugs or biomolecules into the skin or epithelia, or the cytoplasm and/or nucleus of a skin or epithelia cell, of a subject.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: December 27, 2016
    Assignee: CITY UNIVERSITY OF HONG KONG
    Inventors: Li Yan, Xianfeng Chen