Therapeutic Material Introduced Or Removed Through A Piercing Conduit (e.g., Trocar) Inserted Into Body Patents (Class 604/506)
  • Patent number: 12011576
    Abstract: An autoinjector includes a case, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case, a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier, and a trigger button operably coupled to the carrier. The case includes a rib. The needle shroud is movable between a first extended position, a retracted position, and a locked second extended position. The carrier is adapted to hold a medicament container and movable from a first axial position to a second axial position relative to the case. The carrier abuts the rib in the first axial position and the needle shroud is in the first extended position and disengages the rib when the needle shroud is in the retracted position and the trigger button is pressed to advance the carrier to the second axial position.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: June 18, 2024
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Thomas Kemp
  • Patent number: 11980367
    Abstract: Implantable medical devices for connecting tissue layers, such as for connecting a gallbladder and a portion of a gastrointestinal tract to create an anastomosis, include a tubular structure having a plurality of apposition portions, a central region, and a covering material. The methods of using the devices include endoscopic deployment, and the devices may include self-expanding frameworks that facilitate a secure connection between the tissue structures.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: May 14, 2024
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Michael J Houghton, Sakthi Sambandam, Clifford P. Warner
  • Patent number: 11890422
    Abstract: An improved anesthetic nerve block and method is disclosed comprising a dispenser including a storage body, a transfer body and a tip for positioning adjacent to the nerve. A local short acting anesthetic is in the storage body. A physiologic carbonate base is in the storage body. The local short acting anesthetic and the physiologic carbonate base are dispensed from the tip of the dispenser where the local short acting anesthetic facilities the penetration of the physiologic carbonate base through the nerve membrane and into the axon. A local long acting anesthetic is in the storage body. The local long acting anesthetic is dispensed from the tip of the dispenser and penetrates through the nerve membrane and into the axon. The local long acting anesthetic and the physiologic carbonate base cause a precipitate and form a crystallization compound for creating a prolonged local nerve block.
    Type: Grant
    Filed: May 5, 2023
    Date of Patent: February 6, 2024
    Assignee: PFOF LLC
    Inventors: Howard L. Howell, Ralf Blackstone
  • Patent number: 11883541
    Abstract: The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: January 30, 2024
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Peter A. Campochiaro, Jordan Green, Jayoung Kim, Jikui Shen
  • Patent number: 11883638
    Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: January 30, 2024
    Assignee: KORU Medical Systems, Inc.
    Inventors: Andrew I Sealfon, Christopher Erol Ogut
  • Patent number: 11865305
    Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: January 9, 2024
    Assignee: Washington Biotech Corporation
    Inventor: Ronald E. Wyrick
  • Patent number: 11832879
    Abstract: The present invention relates to flexible sheath assemblies capable of maintaining a desired positioning at a desired tissue region during medical procedures involving use insertion and withdrawal of medical tools through the flexible sheath, and related systems and methods.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: December 5, 2023
    Assignee: NeuWave Medical, Inc.
    Inventors: Matthew Schaning, Nicholas Katrana, Matthew Thiel, Louis Mingione, Mark Thom, Richard Schefelker
  • Patent number: 11819663
    Abstract: The invention relates to an automatic injector device comprising a single-use, disposable, drug delivery assembly comprising a housing and a syringe assembly located at least partially within the housing, said syringe assembly including a plunger, a pre-filled unit-dose drug containing chamber, and needle, said plunger, drug containing chamber and needle being configured and dimensioned to function as an injection syringe; a reusable motorized transmission assembly comprising a housing, a motor and transmission assembly located within the housing, said transmission assembly being configured and dimensioned to engage the plunger of said syringe in the drug delivery assembly and expel said unit dose drug from the drug containing chamber, into the needle and out of the drug delivery assembly; said single-use disposable drug delivery assembly and said reusable motorized transmission assembly are in substantial axial alignment along a longitudinal axis defined by the syringe, plunger, pre-filled unit-dose drug con
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 21, 2023
    Assignee: BIOCORP PRODUCTION S.A.
    Inventors: Alain Marcoz, Alexandre Pereira, Mathieu Pollard
  • Patent number: 11806513
    Abstract: Plunger rod stops attach to existing syringes to limit the range of motion of the plunger, thereby to precisely control the amount of liquid that can be expelled from the syringe when the plunger rod stop is in place. In some embodiments, plunger rod stop devices generally include a body configured to attach to the plunger, and a stand-off extending from the body, configured to contact the finger flange when the plunger is depressed. In other embodiments, the plunger rod stop attaches to the finger flange or other fixed component of the syringe and the stand-off is configured to contact the plunger or plunger rod. Methods of the invention involve using the devices to interfere with the range of motion of the plunger, then reconfiguring or removing the device to allow the plunger to be moved a predetermined length, which corresponds to a precise dosage amount.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: November 7, 2023
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Steve Bowman, Chase Fetzer, Richard Braga, Evi Shiakolas
  • Patent number: 11801343
    Abstract: Certain aspects of the present disclosure provide a surgical system comprising a fluid output device capable of connecting to a syringe comprising a material for delivery to a body part through a cannula connected to the syringe and a controller configured to adjust a pressure of the fluid output to enable a controlled delivery of the material within the syringe at a target flow rate.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: October 31, 2023
    Assignee: Alcon Inc.
    Inventors: Pooria Sharif Kashani, Omeed Paydar
  • Patent number: 11786652
    Abstract: The present disclosure provides improved methods for calibrating the zero position of at least one drive member of an injector system is disclosed. Automated methods of position calibration of the drive member of a fluid injector are disclosed. These methods address sources of error in positional accuracy and fluid delivery inaccuracies, such as disposable syringe tolerance and injector wear over time. According to other embodiments of the present disclosure, methods and fluid injector systems for determining and correcting for the amount of slack in a fluid injection apparatus are described. An understanding of the calibration and the amount of slack in a fluid injection system allows a processor to correct for the slack, thereby ensuring more accurate fluid delivery to the patient and more accurate imaging processes.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 17, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, Chelsea Marsh, Michael Spohn, William Barone, Shahab Taheri, Han Min Thu, David Coleman, Jee Hoon Yoo, Vince Delbrugge
  • Patent number: 11771824
    Abstract: A system and method is provided for detecting fluid low-volume and occlusion in a device using force sensing resistor (FSR) sensor. One or more force sensing resistors are positioned in communication with a fluid channel at one or more of a pump intake and pump outlet to detect pressure in the fluid channel. The pressure is detected through communication with the force sensing resistor and indicates an irregular system condition including but not limited to, fluid low-volume level and occlusion. Also provided are a fluid flow sensor (e.g., FSR or MEMS sensor) disposed relative to an embedded fluid channel in the base of a wearable medicine delivery pump.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: October 3, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Alessandro Pizzochero, J. Richard Gyory, Joseph Iskandar
  • Patent number: 11712522
    Abstract: A medicine dosing device for delivering sequential doses of medication to a patient. The medicine dosing device includes a substantially transparent vessel for holding the medication therein. A visual dosing aid such as a dosing bar is present on a surface of the vessel. The visual dosing aid includes a plurality of dosing segments where each of the dosing segments identifies a volume of the medication corresponding to one of a plurality of medication doses to be sequentially provided to the patient. The visual dosing aid may be of a color or pattern that is correlated to at least one physical characteristic of the patient.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: August 1, 2023
    Assignee: CD Acquistions, LLC
    Inventor: Caleb Hernandez
  • Patent number: 11679201
    Abstract: A blood glucose control system can generate an indication of total carbohydrate therapy over a period during use by a subject. The system can be connected to a medicament pump configured to deliver insulin therapy, other types of medicament therapy, or a combination of medicament therapies to the subject. The system can determine an amount of a counter-regulatory agent to respond to an impending risk of hypoglycemia or an episode of hypoglycemia and determine a dose of carbohydrate therapy based at least in part on the amount of the counter-regulatory agent. The system can track determined doses of carbohydrate therapy to generate the indication of total carbohydrate therapy over the period.
    Type: Grant
    Filed: June 16, 2021
    Date of Patent: June 20, 2023
    Assignee: BETA BIONICS, INC.
    Inventors: Firas H. El-Khatib, Edward R. Damiano
  • Patent number: 11666699
    Abstract: A piercing conduit to deliver medications to a user in a painless method including a placement phase, an inserting phase and an injection phase which are performed by the piercing conduit. The placement phase includes a penetrating bottom distal end of the piercing conduit which is inserted through a user's skin of the abdomen portion to place a middle aperture in the inside of the user's skin and then leave exposed the penetrating bottom distal end and a top distal end. The inserting phase passes through a sealing cap from the top distal end which has an aperture in which a needle is inserted along a conduit portion and then reaches the middle aperture that is placed inside of the user's skin. The injection phase delivers the medication with the syringe by the needle allowing to apply medication in a painless method. The piercing conduit is configured to be applied to users with constant medication such as diabetes or dialysis.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: June 6, 2023
    Inventors: Julio Martin Garcia Ruiz, Angie Rose Garcia Ruiz
  • Patent number: 11660421
    Abstract: A medical manipulator includes: an end effector provided at a distal side of the medical manipulator; a proximal housing provided at a proximal side of the medical manipulator; and an elongated portion coupled to both the end effector and the proximal end. The elongated portion includes: a first elongated member coupled to both the end effector and the proximal housing; a second elongated member coupled to only either one of the end effector and the proximal housing, the second elongated member being configured to form by surrounding the first elongated member; and to be slidable in a longitudinal direction relative to the first elongated member; and a third elongated member coupled to both the end effector and the proximal housing, the third elongated member being configured to form an exterior of the elongated portion by surrounding the second elongated member.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: May 30, 2023
    Assignee: OLYMPUS CORPORATION
    Inventor: Mitsuaki Hasegawa
  • Patent number: 11623037
    Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: April 11, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
  • Patent number: 11596307
    Abstract: The present disclosure relates to systems and methods for activating a circuit of an implant device. Consistent with one implementation, an implant device is provided with a sensor including a working electrode (WE) and a counter electrode (CE). The sensor may be configured to generate a first current at the CE when the implant device is implanted in a body of a subject. A sensing circuit may also be provided that is electrically coupled to the WE of the sensor. The sensing circuit may be activated based on the first current and utilize the sensor to measure one or more parameters of an individual or other subject.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: March 7, 2023
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Alireza Dastgheib, Johan Vanderhaegen
  • Patent number: 11571507
    Abstract: Certain embodiments provide multi-medicament or single medicament infusion systems for preventing the cross-channeling or improper delivery of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The medicament cartridges may be sized and shaped differently such that the medicament reservoirs can only be inserted into the pump under selected configurations.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: February 7, 2023
    Assignee: Beta Bionics, Inc.
    Inventors: Edward R. Damiano, David Matthew Henderson, Bryan Dale Knodel, Michael J. Rosinko, Justin P. Brown, Todd S. Ray, Mads Henrik Dall, David Chi-Wai Lim
  • Patent number: 11565046
    Abstract: An auto-injector is provided which includes a housing with a syringe slidably received therein. The syringe has a barrel with a piston movable therein and a needle extending therefrom. The piston is releasably secured to one end of a plunger which is slidably secured within a body in the housing and is operable through a bias provided by a motive source. In use, the plunger moves under the bias from a loaded condition to a discharged condition to move the syringe so that the needle extends from a tip at an injection end of the housing and to slide the piston within the barrel to expel the contents of the syringe. The plunger is held in the loaded condition against the bias by a detent extending from the body and which can be selectively released by operation of an actuator when pressure is applied to the tip.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: January 31, 2023
    Assignee: UNIVERSITY OF CAPE TOWN
    Inventors: Gokul Arjunan Nair, Michael Levin, Sudesh Sivarasu
  • Patent number: 11559635
    Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: January 24, 2023
    Inventors: Andrew I. Sealfon, Christopher Erol Ogut
  • Patent number: 11559615
    Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for receiving a conductivity or sodium concentration set point for the dialysis fluid and for calculating a mass transport of a substance at an instant t of a treatment session based on said set value of the parameter for the dialysis fluid in the dialysis supply line (8).
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: January 24, 2023
    Assignee: Gambro Lundia AB
    Inventor: Anders Nilsson
  • Patent number: 11541016
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: January 3, 2023
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, Michael Williams, Jacob Wainer
  • Patent number: 11541015
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: January 3, 2023
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Patent number: 11534597
    Abstract: Techniques for providing therapy to a patient via electrical stimulation are described. The techniques include, for example, determining, relative to a start time of providing the electrical stimulation, one or more efficacy times that correspond to an efficacy indicator, determining, according to the efficacy times, efficacy data items for the patient, comparing the efficacy data items with the efficacy indicator, and generating, based on the comparison, a prediction of an expected response to the therapy manifesting in the patient at a prospective time.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: December 27, 2022
    Assignee: Medtronic, Inc.
    Inventors: Louis P. Vera-Portocarrero, Nathan A. Torgerson, Melanie D. Goodman Keiser
  • Patent number: 11524301
    Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: December 13, 2022
    Assignee: Cepheid
    Inventors: Douglas B Dority, Tien Phan, David Fromm, Richard J. Casler, Jr., Dustin Dickens, Stuart Morita, Matthew Piccini
  • Patent number: 11511053
    Abstract: A needle hub (10) for a pen needle is provided with an enlarged surface for contact with the skin of a patient. The enlarged surface is provided with a surface having a dimension and shape to enable a needle or cannula to penetrate the skin to a desired depth and permit substantially the entire exposed length of the needle or cannula to penetrate the skin to the desired depth. The surface of the needle hub can be formed by an inner cone shaped member (26) forming a first contact surface with a surface area of about 1-5 mm2 and an outer ring (28) at a peripheral edge forming a second contact surface with a combined surface area of about 15 to 50 mm2.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: November 29, 2022
    Assignee: Embecta Corp.
    Inventors: Christopher Rini, Richard Klug, Bruce Roberts, Didier Morel, Ronald Pettis
  • Patent number: 11510883
    Abstract: A kit for enabling delivery of an active compound to the skin for penetration into the skin, a delivery device for delivering an active compound, and a method of delivery of an active compound are provided. An active compound delivery kit for enabling delivery of an active compound into the skin of a subject includes an arrangement for providing a pathway into a biological barrier of a subject in an application zone, an active compound provided in dry form, and a delivery device for delivery of dissolved active compound to the application zone. Provision of a pathway into the biological barrier, preferably skin, is provided and the active compound applied in optimum form within a short time frame after forming the pathway ensuring treatment of the desired skin cells is optimised.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: November 29, 2022
    Assignee: XOBADERM LIMITED
    Inventor: Andrew Kirby
  • Patent number: 11505353
    Abstract: The invention relates to a method for inverting the diaphragm of a filled and capped container. According to the invention, the container is placed on a support ring of an inversion device, a pressing member is applied to the container and a pusher is raised through the support ring to invert the diaphragm and shape the diaphragm into an arch. While the pusher inverts the diaphragm, the seat is moved away from the upper plane of the support ring, so that when the pusher reaches the raised position, a space is opened between the seat and the support ring to enable a longitudinal expansion of the container under the combined effect of the increase in internal pressure caused by the decrease in the volume due to the inversion and the forces generated inside the container by the pusher and the support member.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: November 22, 2022
    Assignee: SIDEL PARTICIPATIONS
    Inventors: Florian Godet, Jérôme Neveu
  • Patent number: 11484594
    Abstract: Various embodiments of bulking or cushioning agents or material and related medical devices and methods are disclosed. For example, a method of performing a medical procedure in a tract of a body may include injecting a material in a liquid phase proximate a target site between a first tissue layer and a second tissue layer, allowing the material to transition from the liquid phase to the gel phase in response to a raise in temperature of the material to approximately at or above the predetermined temperature, and performing a surgical procedure on the target site. The material may have the liquid phase at temperatures below a predetermined temperature and a gel phase at temperature approximately at or above the predetermined temperature.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: November 1, 2022
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Paul Scopton, Samuel Zhong, Yem Chin
  • Patent number: 11478581
    Abstract: A system and method for correcting a volume of fluid delivered by a fluid injector during an injection procedure is described. The method included determining and compensating for a volume factor associated with compliance of the fluid injector system and correcting for the volume by one of over-driving the distance that the drive member travels in a fluid reservoir, under-driving the distance that the drive member travels in the fluid reservoir, or lengthening or shortening a fluid delivery time.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 25, 2022
    Assignee: Bayer HealthCare LLC
    Inventors: Michael McDermott, Michael Spohn, William Barone, Chelsea Marsh
  • Patent number: 11464674
    Abstract: The present disclosure relates to relates to systems and methods for on-demand delivery of a therapeutic agent from an eye mounted device. Particularly, aspects of the present invention are directed to a method of delivering a therapeutic agent, the method including receiving, at a controller of a therapeutic agent release and delivery device, a first command signal for delivery of a therapeutic agent based on a dosing time window. Upon receipt of the first command signal, the controller determines whether one or more compliance conditions are satisfied. When the one or more conditions are satisfied, the controller initiate a release and delivery protocol that commands a signal generator to generate and send a second command signal causing a capacitor or one or more circuits to deliver an actuation signal causing one or more therapeutic agent delivery mechanisms to open and release the therapeutic agent from one or more reservoirs.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: October 11, 2022
    Assignee: TWENTY TWENTY THERAPEUTICS LLC
    Inventor: Christian Gutierrez
  • Patent number: 11464911
    Abstract: A medicament delivery system, including a medicament container and a delay mechanism that is activated prior to completion of medicament delivery from the medicament container. The delay mechanism automatically activates a subsystem or initiates an operation subsequent to completion of medicament delivery.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: October 11, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Peter Krijger, Philip Song, Curt Bingham, Stephen C. Simmons, Paul Alchas
  • Patent number: 11464900
    Abstract: An insertion mechanism for a drug delivery device including a trocar, a housing, and a manifold in fluid communication with a fluid pathway connector and movable relative to the housing between a first manifold position adjacent to a proximal end of the housing and a second manifold position adjacent to a distal end of the housing. A hub carrying the trocar or hollow delivery needle is removably connected to the manifold, the hub being movable relative to the housing between a first hub position adjacent to the proximal end of the housing and a second hub position adjacent to the distal end of the housing. A power source is configured to generate rotational motion. A motion conversion mechanism operatively connects the power source and the hub, and is configured to convert the rotational motion into linear motion of the hub.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: October 11, 2022
    Assignee: AMGEN INC.
    Inventors: Adam B. McCullough, Erich Coiner, Alan D. Payne
  • Patent number: 11439741
    Abstract: Disclosed herein are several embodiments of a negative pressure apparatus and methods of using the same in the treatment of wounds. Some embodiments are directed towards improved fluidic connectors configured to transmit irrigation fluid and to apply aspiration to a wound, for example using softer, kink-free conformable layers. Some embodiments may comprise a first channel for delivering irrigation fluid to the wound and a second channel for transmitting negative pressure and removing fluid comprising irrigation fluid and wound exudate from the wound, wherein the channels comprise a flexible spacer material. Some embodiments are directed toward an irrigation manifold attachable to or incorporated as part of a distal end of an irrigation and aspiration fluidic connector.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: September 13, 2022
    Assignee: Smith & Nephew PLC
    Inventor: Edward Yerbury Hartwell
  • Patent number: 11439752
    Abstract: Infusion devices, systems, and related operating methods are provided. A method of detecting an anomalous condition with respect to a fluid path based on operation of an actuation arrangement configured to deliver fluid via the fluid path involves providing input power to the actuation arrangement to produce actuation of the actuation arrangement, identifying an active amount of actuation of the actuation arrangement concurrent to the input power being provided to the actuation arrangement, disabling the input power to the actuation arrangement, identifying a passive amount of actuation of the actuation arrangement after disabling the input power to the actuation arrangement, and detecting the anomalous condition based on a relationship between the active amount and the passive amount.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: September 13, 2022
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Afshin Bazargan, Adam S. Trock
  • Patent number: 11426523
    Abstract: A drug delivery assembly is used for delivering a medicament to a patient. The assembly includes a main body having a housing and defining a recess, with an actuator associated with the housing. An adhesive pad, configured to attach to a human body surface, is associated with a lower surface of the housing. The assembly also includes a cartridge configured to be at least partially inserted into the recess and having: a cartridge housing, a drug reservoir positioned within the cartridge housing, a stopper movably associated with the drug reservoir, and a needle movably associated with the drug reservoir. The actuator is manipulated to deploy the needle, with the actuator also engaging the cartridge to prevent removal of the cartridge from the recess during drug delivery. A rod of the body engages the stopper to move the stopper and dispense a medicament from the drug reservoir during drug delivery.
    Type: Grant
    Filed: February 19, 2021
    Date of Patent: August 30, 2022
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: David R Schiff, Sharon D West
  • Patent number: 11426565
    Abstract: A method and apparatus are disclosed for an optimized transseptal procedure for providing left heart access, that reduces the number of devices that are used in order to minimize procedural time, complexity and cost. The apparatus comprises a hybrid dilator that comprises the combined functionality of a transseptal sheath and dilator assembly. The hybrid dilator comprises: a dilator shaft defining a lumen for receiving a crossing device therethrough, the dilator shaft being structured to provide support for the crossing device when the crossing device is used to create a puncture in a tissue; and a distal tip having an outer diameter which tapers down to an outer diameter of the crossing device for providing a smooth transition between the crossing device and the distal tip when the crossing device is inserted through the lumen and protrudes beyond the distal tip.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: August 30, 2022
    Assignee: Boston Scientific Medical Device Limited
    Inventors: Melanie Thomspon Smith, Gareth Davies, Linus Hoi Che Leung
  • Patent number: 11426526
    Abstract: A dispensing device is provided to dispense a designated amount of a material on every dose delivery operation. The dispensing device includes a thumb pad, a cam drum coupled to the thumb pad, and a pawl nut comprising a one-way pawl. The thumb pad may be pulled out in a direction away from a distal end of the dispensing device for setting a dose of the material to be dispensed out and may be pushed in towards the distal end for delivering the dose. The cam drum includes a plurality of linear cam profiles and a plurality of helical cam profiles that may be disposed on a surface of the cam drum. The one-way pawl may engage with a ratchet disposed at a distal end of the cam drum and may prevent a rotation of the cam drum in an undesired direction.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: August 30, 2022
    Assignee: Tata Elxsi Limited
    Inventors: Vasanthan Mani, Suresh Kumar Natarajan
  • Patent number: 11413392
    Abstract: There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system comprises, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive comprising a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device comprises a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: August 16, 2022
    Assignee: SOCIETE INDUSTRIELLE DE SONCEBOZ SA
    Inventors: David Staub, Thierry Martin, Nicolas Bailo, Denis Tilloy
  • Patent number: 11395884
    Abstract: The present invention provides a drug delivery system (1) comprising a drug delivery device (2, 3) carrying at least one reservoir (40a, 40b), and a needle unit (4) being attachable to the drug delivery device (2, 3) in axial extension thereof and adapted to establish a flow way between the at least one reservoir (40a, 40b) and a drug delivery site. The needle unit (4) comprises a needle structure (11) comprising a front needle portion (12) for entering the drug delivery site, and at least one back needle portion (13a, 13b) for insertion into the at least one reservoir (40a, 40b), and a needle shield (20).
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: July 26, 2022
    Assignee: Novo Nordisk A/S
    Inventor: Roger Harrington
  • Patent number: 11364345
    Abstract: An injector device for delivering a liquid medicament comprises an injector body having a proximal end and a distal end. The injector device further includes a syringe slidably received in the injector body and moveable from a first position to a second position towards the distal end of the body. Additionally, the injector device comprises a needle holder between the syringe and the distal end of the body, and a needle held in the needle holder. The needle has a distal end extending toward an opening in the distal end of the body, and a proximal end extending toward the syringe. The injector device also comprises a syringe biasing member within the body configured to bias the syringe into the second position. The syringe is spaced from the needle in the first position and is in engagement with the proximal end of the needle in the second position.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: June 21, 2022
    Assignee: Sanofi
    Inventors: Francisco Soares, Bernhard Forys, Stefan Verlaak, Ilario Melzi
  • Patent number: 11324894
    Abstract: An assembly for a drug delivery device comprises a housing, a dose member which is displaceable in a proximal direction with respect to the housing for setting of a dose of a drug, a clutch member which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member configured to define a clutch stop position. The clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: May 10, 2022
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Strehl, Udo Leuschner, Norbert Besenhardt
  • Patent number: 11291671
    Abstract: The present invention provides for pharmaceutical preparations, devices, systems and methods for the treatment of otic diseases and conditions. In various embodiments, the preparations, devices, systems and methods enable sustained drug release for the treatment or prevention of hearing loss, infections, and other pathological conditions of cochlea and inner ear.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: April 5, 2022
    Assignee: O-Ray Pharma, Inc.
    Inventors: William H. Slattery, Thomas Smith, Erik Pierstorff, Marc M. Baum
  • Patent number: 11273262
    Abstract: A medicament delivery device includes a case, a first plunger, a second plunger arranged telescopically with the first plunger, a first drive spring biasing the second plunger relative to the case, and a second drive spring biasing the first plunger relative to the second plunger.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: March 15, 2022
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Uwe Dasbach
  • Patent number: 11253652
    Abstract: A device (1) for dispensing a substance to a patient comprising a cylindrical first container (2) containing the substance and a second container (3) containing a liquid. The device further comprises an injection device (4) and transfer mechanism (5) for transferring the liquid from the second container (3) to the first container (2) and from the first container (2) to the injection device (4). The first container (2) has a connection element (7) and a plunger (9) that can be moved between the first (6) and second ends (8). By moving the plunger (9) towards the first end (6), liquid contained therein can be dispensed via the injection device (4). The injection device (4) comprises a piercing cannula (15) and an indwelling cannula (16). In an initial position, a distal end region of the piercing cannula (15) extends coaxially in the interior of the indwelling cannula (16).
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: February 22, 2022
    Assignee: SHL MEDICAL AG
    Inventors: Christoph Egloff, Ludwig Daniel Weibel
  • Patent number: 11234729
    Abstract: Embodiments of the present invention disclose micro-lipo needle device and methods of making and using the same.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: February 1, 2022
    Assignee: AURASTEM LLC
    Inventors: Bradford A. Conlan, Lucas Fornace
  • Patent number: 11207508
    Abstract: Inventive embodiments disclosed herein include a catheter for dilating a sinus cavity lumen. The catheter includes a guide tube, having a proximal end and a distal end, that terminates in a distal tip; a sleeve member annularly positioned over the guide tube, wherein the sleeve member is movable relative to the guide tube and is capable of being advanced over the guide tube; and a balloon coupled to the sleeve member, wherein the balloon can be extendable and inflated at or beyond the end of the guide tube.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: December 28, 2021
    Assignee: Entellus Medical, Inc.
    Inventors: Thomas V. Ressemann, John R. Drontle, Anthony J. Hanson, Peter T. Keith
  • Patent number: 11202753
    Abstract: The present invention provides a method for generating an immune response in a subject, comprising administering to the subject's skin an immunizing composition from a SARS-CoV-2 pathogen, wherein the composition is administered with a microneedle delivery device.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: December 21, 2021
    Inventors: Sobin Chang, Daniel J. Nevrivy, Saiprasad Sankaranarayanan
  • Patent number: 11197984
    Abstract: Provided are a microneedle array capable of improving the visibility of an appearance inspection, and a manufacturing method of the same. A microneedle array is a microneedle array including: a sheet portion having a first surface and a second surface which oppose each other; and a plurality of needle portions arranged on the first surface of the sheet portion, in which the second surface of the sheet portion is configured by a rough surface having peak portions and valley portions, and an average transmittance of the sheet portion in a wavelength range of 300 nm to 740 nm is 75% or less.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: December 14, 2021
    Assignee: FUJIFILM Corporation
    Inventor: Kenichiro Tamaki