Therapeutic Material Introduced Or Removed From Natural Body Orifice Patents (Class 604/514)
  • Patent number: 11324934
    Abstract: This disclosure relates to procedures for administering a blockade of the sphenopalatine ganglion (“SPG”). Methods may include advancing a catheter through nostril at least 8 cm. Methods may include advancing the catheter through an inferior meatus. Methods may include causing the catheter to bend after contacting posterior wall of the nasal cavity. Methods may include advancing the catheter superiorly to a position posterior to the middle turbinate. Methods may include advancing the catheter superiorly to a position posterior to the superior turbinate. Methods may include advancing the catheter superiorly into a sphenoethmoid recess. Methods may include bringing a distal tip of the catheter in contact with the SPG. Methods may include ejecting an anesthetic from a distal tip of the catheter and bathing the SPG to administer a blockade of the SPG.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: May 10, 2022
    Inventor: Sana Louis Bloch
  • Patent number: 11298267
    Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: April 12, 2022
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
  • Patent number: 11206972
    Abstract: A system for accessing a body cavity, such as a paranasal sinus, may include a sinus access member and a handle. The sinus access member may include a rigid support tube, a curved shape memory member slidably disposed at least partially within the rigid support tube, a flexible tube slidably disposed over at least part of the curved shape memory member, and proximal coupling end. The handle may include an engagement mechanism at a distal end for releasably attaching to the proximal coupling end of the sinus access member, a housing for gripping with a hand, a curving slider for extending and retracting the curved shape memory member, and an extension slider for extending and retracting the flexible tube relative to the curved shape memory member and the rigid support tube. The handle may be reusable, and the sinus access member may be disposable.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: December 28, 2021
    Assignee: 3NT Medical Ltd.
    Inventors: Ehud Bendory, Eran Bendory, Gil Hefer
  • Patent number: 11191558
    Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: December 7, 2021
    Assignee: COVIDIEN LP
    Inventors: Hoai Nguyen, Gaurav Girdhar, Andyanhdzung Huynh, Ujwal Jalgaonkar, Eric Mintz, Ashok Nageswaran, John Wainwright, James Davidson
  • Patent number: 11173113
    Abstract: A method and kit for the sequential early introduction to an infant of at least two allergens to decrease the infant's risk for developing allergies, the method involving administering an initial lower, exposure dose of a first allergen for a day or two, followed by administering a higher maintenance dose of the first allergen for several days, followed by administering the maintenance dose of the first allergen and an initial lower, exposure dose of a second allergen for a day or two, followed by administering the higher maintenance dose of the first allergen and a higher maintenance does of the second allergen for several days. The allergens can be provided in powdered protein form in premeasured pouches for addition to baby formula or to mother's milk. Alternatively, the allergens can already be provided in baby formula, or in other foods such as snack bars, cookies, or gels.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 16, 2021
    Assignee: PROLLERGY CORPORATION
    Inventors: Andrew Leitner, Katie Marks, Aaron Rowe, Daniel Zakowski
  • Patent number: 11160532
    Abstract: A method of generating an image of a medical instrument using a medical apparatus includes a catheter, a medical instrument assembly, and an imaging assembly. The catheter has a first working channel terminating with a first distal exit, and a second working channel terminating with a second distal exit. The medical instrument assembly has a medical instrument adapted to be housed within the first working channel and adapted to be extendable through the first distal exit to an extended position beyond the first distal exit to intercept a target tissue. The imaging assembly includes an imaging device adapted to be housed within the second working channel and is extendable through the second distal exit to an extended position beyond the second distal exit. The imaging device is adapted to generate an image in an image plane of the distal end of the medical instrument when the distal end of the medical instrument is extended out the first distal exit.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 2, 2021
    Assignee: Veran Medical Technologies, Inc.
    Inventors: Mark Hunter, Troy L Holsing
  • Patent number: 11123008
    Abstract: A feeding transition system for transitioning an infant subject to oral feeding includes at least one no-flow nipple and at least one flow nipple. The no-flow nipple has a fully enclosed tip portion such that no fluid can flow directly from the nipple cavity through the nipple wall. The flow nipple is formed of a no-flow nipple having an aperture formed in the tip portion for flowing fluid from the nipple cavity through the nipple wall. The system includes a bolus delivery nipple formed of a no-flow nipple including a bolus delivery conduit disposed in the nipple cavity and in fluid communication with a reservoir of fluid. The bolus delivery conduit includes a conduit outlet attached to the nipple wall to output a bolus of fluid from the tip portion of the bolus delivery nipple via the outlet. A method for transitioning an infant subject to oral feeding is provided.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: September 21, 2021
    Assignee: NFANT Labs LLC
    Inventors: Thomas J. Cunningham, Louis F. Malice, Jr., Moreed Khosravanipour, Gilson J. Capilouto
  • Patent number: 10966866
    Abstract: An instrument comprises a shaft assembly, a handpiece body, and a drive assembly. The shaft assembly comprises a plurality of coaxially arranged shafts and a tympanostomy tube. The shaft assembly further includes a flexible section. The shaft assembly extends distally from the handpiece body. The drive assembly is operable to drive the shafts of the shaft assembly in a predetermined sequence to deploy the tympanostomy tube. One or more of the shafts are configured to translate along the flexible section of the shaft assembly as a part of the predetermined sequence to deploy the tympanostomy tube.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: April 6, 2021
    Assignee: TUSKER MEDICAL, INC.
    Inventors: Nga K. Van, Mathew D. Clopp, Scott J. Baron, Thomas D. Gross
  • Patent number: 10933179
    Abstract: A breast pump system having a suction tubing, a milk tubing, a pump, a three way vent valve, a milk bottle, an isolation valve and a breast shield, wherein the first end of the suction tubing and the first end of the milk tubing are fluidly connected to the pump; wherein the second end of the suction tubing and the second end of the milk tubing are fluidly connected to the breast shield; wherein the three way vent valve is fluidly connected between the pump and the breast shield on the suction tubing; wherein the milk bottle is fluidly connected on the milk tubing between the breast shield and the pump; and wherein the isolation valve is connected on the milk tubing between the milk bottle and the pump.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 2, 2021
    Inventors: Jared Miller, Samantha Rudolph
  • Patent number: 10894013
    Abstract: A method and kit for the sequential early introduction to an infant of at least two allergens to decrease the infant's risk for developing allergies, the method involving administering an initial lower, exposure dose of a first allergen for a day or two, followed by administering a higher maintenance dose of the first allergen for several days, followed by administering the maintenance dose of the first allergen and an initial lower, exposure dose of a second allergen for a day or two, followed by administering the higher maintenance dose of the first allergen and a higher maintenance does of the second allergen for several days. The allergens can be provided in powdered protein form in premeasured pouches for addition to baby formula or to mother's milk. Alternatively, the allergens can already be provided in baby formula, or in other foods such as snack bars, cookies, or gels.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: January 19, 2021
    Assignee: PROLLERGY CORPORATION
    Inventors: Andrew Leitner, Katie Marks, Aaron Rowe, Daniel Zakowski
  • Patent number: 10814076
    Abstract: A method of increasing eustachian tube patency in human patients is disclosed wherein a eustachian tube targeting nasal administration device is utilized to deliver a surfactant/propellant mixture to the nasopharyngeal stoma of the auditory tube. The targeting capability of the administration device obviates the need for a spreading agent that would otherwise be required to enable at least a portion of surfactant to reach the eustachian tube orifice. More specifically, the non-targeting, indiscriminate delivery provided by nasal administration devices of the past required surfactant to spread over non-targeted tissue it was inadvertently applied to in order to reach the eustachian tube stoma. In addition, a method for treatment of otitis media is disclosed utilizing, in some preferred embodiments, a therapeutically active agent.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: October 27, 2020
    Inventors: Alex Nyirucz, Richard Lee Strauss, Alan Joseph Mautone
  • Patent number: 10689460
    Abstract: Embodiments provide swallowable devices, preparations and methods for delivering therapeutic agents (TAs) within the GI tract such as antibodies (AP-antibodies) or other proteins which neutralize PCSK9 molecules. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and/or peritoneum and degrade to release the TA into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments are particularly useful for delivery of AP-antibodies and related TA's for the treatment of cholesterol, lipid and related conditions where such TAs are poorly absorbed and/or degraded within the GI tract.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 23, 2020
    Assignee: Incube Labs, LLC
    Inventors: Mir Imran, Radhika Korupolu, Elaine To, Joel Harris, Mir Hashim
  • Patent number: 10610348
    Abstract: An endoscopic stent for implantation in a patient after sleeve gastrectomy or biliopancreatic diversion with duodenal switch or biliopancreatic diversion with duodenal switch comprising a stent portion, the stent portion comprising a proximal end portion, the proximal end portion defined by a length of about 50 mm to about 200 mm, an enlarged middle portion, a middle portion having an enlarged diameter relative to the proximal end portion and the distal end portion and defined by a length of about 20 mm to about 80 mm, and a distal end portion and a polymeric sleeve portion engaged to and extending distally from the distal end portion of the stent.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: April 7, 2020
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: John A. Hingston, Claude O. Clerc, Jonathan Root, Vishal Shah
  • Patent number: 10603473
    Abstract: Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: March 31, 2020
    Assignee: Intersect ENT, Inc.
    Inventors: Richard E. Kaufman, John Joseph Stankus, James Su
  • Patent number: 10518070
    Abstract: The device for powdering a solid unit dosage form of medication and administering the powder form includes an applicator, a powdering tool and, in certain embodiments, a cap. The device is used to create a powder form from a solid unit dosage form, and then administer the powder form to a body cavity of a patient. The cap is provided with an integrated powdering tool, allowing an open end of an applicator barrel to be releasably covered thereby. Manipulation of the powdering tool creates the powder form through abrasion of a solid unit dosage form of the medication received within the barrel. The cap and powdering tool may then be removed, leaving the powder form of the solid unit dosage form to be administered to the body cavity, such as a patient's vagina or rectum.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: December 31, 2019
    Assignee: King Saud University
    Inventor: Mohd Aftab Alam
  • Patent number: 10512720
    Abstract: A syringe includes a barrel having a distal end, a proximal end, and a sidewall extending therebetween along a longitudinal axis. At least one engagement member protrudes from a terminal portion of the sidewall in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end. The at least one engagement member is configured for engagement with a locking mechanism of a fluid injector to releasably lock the syringe with the fluid injector. A taper of the at least one engagement member is configured to rotationally guide the syringe into alignment with the locking mechanism and axially eject the syringe upon rotation of the syringe. The locking mechanism operatively engages the at least one engagement member regardless of an orientation of the syringe about the longitudinal axis relative to the injector.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: December 24, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Barry L. Tucker, Arthur E. Uber, III, Edward J. Rhinehart, James R. Neill, Glen P. Williams, Michael A. Spohn
  • Patent number: 10448886
    Abstract: A system and method enabling the receipt of image data of a patient, identification of one or more locations within the image data illustrating the effects of COPD, planning a pathway to the one or more locations, navigating an extended working channel to one of the locations, positioning a catheter proximate the location, and temporarily evacuating air from within a portion of a patient's lungs including the identified location illustrating the effects of COPD to temporarily isolate the portion of the lungs including the one or more actual locations.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: October 22, 2019
    Assignee: COVIDIEN LP
    Inventor: William S. Krimsky
  • Patent number: 10441757
    Abstract: Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: October 15, 2019
    Assignee: Intersect ENT, Inc.
    Inventors: Richard E. Kaufman, John Joseph Stankus, James Su
  • Patent number: 10363347
    Abstract: A breast pump system having a suction tubing, a milk tubing, a pump, a three way vent valve, a milk bottle, an isolation valve and a breast shield, wherein the first end of the suction tubing and the first end of the milk tubing are fluidly connected to the pump; wherein the second end of the suction tubing and the second end of the milk tubing are fluidly connected to the breast shield; wherein the three way vent valve is fluidly connected between the pump and the breast shield on the suction tubing; wherein the milk bottle is fluidly connected on the milk tubing between the breast shield and the pump; and wherein the isolation valve is connected on the milk tubing between the milk bottle and the pump.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: July 30, 2019
    Inventors: Jared Miller, Samantha Rudolph
  • Patent number: 10219889
    Abstract: An apparatus is provided that includes an elongate member having a distal end portion, a proximal end portion, and a medial portion that is disposed between the distal end portion and the proximal end portion. The medial portion is configured to be disposed in a ureter of a patient. The apparatus further includes an expandable member that is coupled to the elongate member. The expandable member has an expanded configuration and a collapsed configuration. The expandable member is further configured to be inserted into the ureter of the patient and configured to contact the ureter to help retain the elongate member in place within the patient.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: March 5, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Travis Deal, Ray Amos, Mark Hera, Jennifer Keeler, Jeff Smith, Nancy Deal
  • Patent number: 10195376
    Abstract: A nasal administration device is disclosed which enables delivery of a well collimated stream of medication through the nasal orifice of a human being to the pharyngeal orifice of the eustachian tube. The device utilizes alignment tabs to properly position the collimated stream utilizing facial landmarks and an alignment arrow to confirm such alignment. Certain preferred embodiments of the disclosed device include adjustable alignment tabs enabling more precise alignment for a range of facial profiles.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: February 5, 2019
    Inventors: Alex Nyirucz, Richard Lee Strauss
  • Patent number: 10188695
    Abstract: The present invention relates to a calcineurin inhibitor for use in the treatment of a lesional vestibular disorder.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: January 29, 2019
    Assignees: Sensorion, INSERM
    Inventor: Jonas Dyhrfjeld-Johnsen
  • Patent number: 10039898
    Abstract: A catheter sheath introducer comprises a hub and a tubular sheath having an inner lining with one or more dampers to improve retention of medical devices received or passed through the sheath without significantly increasing the force required to advance the medical device through the sheath. The dampers are made of a friction inducing material, for example, rubber-based materials, and configured as fingers, bumps or flaps that are unidirectional by means of an asymmetrical shape relative to a longitudinal axis of the sheath.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: August 7, 2018
    Assignee: Biosense Webster (Israel) Ltd.
    Inventor: Steven Wu
  • Patent number: 9962524
    Abstract: A securement system includes a securement device which permits various medical articles, for example, an indwelling catheter and one or more medical lines, to be fluidly connected to one another. The securement device can be releasably secured relative to an anchor pad which itself is secured to a patient. In this way, the securement system can secure an interconnection of medical articles relative to a patient.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: May 8, 2018
    Assignee: Venetec International, Inc.
    Inventor: Rafael V. Andino
  • Patent number: 9962397
    Abstract: The intranasal medication delivery device and method of use thereof includes an elongated malleable member arcuately curved or pre-formed in manner complimentary to the anterior wall of a nasal cavity. One particular embodiment provides the elongated and arcuate member to deliver medication through a lumen such that the medication is deposited in a semi-solid state adjacent the anterior aspect of the nasal cavity lateral wall and to the anterior end of the superior, middle, and inferior turbinate. Another particular embodiment provides the elongated and arcuate member to deliver medication as a suppository to a location similar to that of the previous embodiment. The method of delivering the medicine provides depositing the medicine adjacent the anterior end of one of the superior turbinate, middle turbinate, and inferior turbinate. An exemplary medication can be any one of a corticosteroid, an anti-histamine, an immune active mediator, an IgE binding medication, or a decongestant.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: May 8, 2018
    Inventors: John T. Given, William R. Ackerman
  • Patent number: 9901487
    Abstract: A protective device for insertion into the crevice adjacent to the anus, and cover adjacent portions of the derriere. The protective device cover includes a solid sheet of material with an adhesive on one side which can be used to apply the cover directly onto the portion directly around and adjacent to the anus after it has been inserted into the crevice. The cover also includes slits or holes through which evacuated material may pass through. The cover may also be made from a “plastic-wrap” type material that adheres to human skin when pressure is applied. In an alternate embodiment, a wiping pad is provided between two layers of the cover, which traverses the hole opening when a string is pulled to effect at least partial cleaning in the anus area. This almost eliminates the need for toilet paper, keeps the body clean, and avoids excessive contamination.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: February 27, 2018
    Inventor: C. Howard Steinberg
  • Patent number: 9839415
    Abstract: Wound closure devices, systems, and methods may be used to close an opening, such as a puncture wound or incision, formed in tissue, such as heart tissue. A wound closure device may be configured and adapted to be placed within the puncture wound or incision to close and/or seal the puncture wound or incision. A bioadhesive may be used to strengthen the closure and/or seal of the puncture wound after placement of the wound closure device relative to the puncture wound.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: December 12, 2017
    Assignee: St. Jude Medical, LLC
    Inventor: Zachary J. Tegels
  • Patent number: 9839731
    Abstract: An improved accessory light for breast pumps apparatus is described. This improved accessory light for breast pumps apparatus may be secured or affixed to various models of breast pumps to allow the user to have a hands-free, illuminated view of the milk being expressed from the breast. The accessory light may consist of a clamp-based accessory secured to a breast shield neck or an accessory that is secured to the breast shield back using a flexible material.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: December 12, 2017
    Inventors: Patrick Martin O'Malley, Michael David Horning
  • Patent number: 9764121
    Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: September 19, 2017
    Assignees: THE CHARLES STARK DRAPER LABORATORY, INC., MASSACHUSETTS EYE AND EAR INFIRMARY
    Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
  • Patent number: 9662171
    Abstract: Systems, delivery devices, and methods to treat to ablate, damage, or otherwise affect tissue. The treatment systems are capable of delivering a coolable ablation assembly that ablates targeted tissue without damaging non-targeted tissue. The coolable ablation assembly damages nerve tissue to temporarily or permanently decrease nervous system input. The system, delivery devices, and methods can damage tissue and manage scarring and stenosis.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: May 30, 2017
    Assignee: Holaira, Inc.
    Inventors: Steven C. Dimmer, Martin L. Mayse, Mark E. Deem, Hanson S. Gifford, III
  • Patent number: 9610152
    Abstract: A kit for introducing a bladder into a body pocket is provided. The kit comprises a holder having an interior surface, an exterior surface and at least one open end, a balloon catheter, a needle and a bladder. The holder includes a needle sheath formed on the exterior surface. The balloon catheter comprises a balloon and a tube. The needle is secured to the bladder by a suture. The bladder may be positioned in the holder with the needle received in the needle sheath. The bladder may have an inlet and an opening. Through the inlet the balloon catheter and a body prosthesis are introducible into the bladder after the bladder is placed into the body pocket, and through the opening the tube of the balloon catheter is introducible out of the bladder.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: April 4, 2017
    Inventors: Hsu-Wei Fang, Mark Berman
  • Patent number: 9301840
    Abstract: An introducer sheath has a radially unexpanded and a radially expanded configuration, where the sheath locally expands from the unexpanded configuration to the expanded configuration when a device is advanced through a lumen thereof, and locally contracts back to the unexpanded configuration after the device advances past that location. Embodiments of the introducer sheath include an outer tubular layer comprising a longitudinal cut therethrough, and an inner tubular layer comprising at least one pleat extending through the longitudinal cut to an outside surface of the outer tubular layer. Embodiments of the inner tubular layer are adhered to an inner surface of the outer tubular layer, with the pleat not adhered to an outer surface of the outer tubular layer.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 5, 2016
    Assignee: Edwards Lifesciences Corporation
    Inventors: Duy Nguyen, Kim D. Nguyen
  • Patent number: 9241735
    Abstract: Disclosed is an expandable percutaneous sheath, for introduction into the body while in a first, low cross-sectional area configuration, and subsequent expansion to a second, enlarged cross-sectional configuration. The sheath is maintained in the first, low cross-sectional configuration by a tubular restraint. In one application, the sheath is utilized to provide access for a diagnostic or therapeutic procedure such as percutaneous nephrostomy or urinary bladder access.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: January 26, 2016
    Assignee: Onset Medical Corporation
    Inventors: George F. Kick, Thanh Van Nguyen, Samuel M. Shaolian
  • Patent number: 9233050
    Abstract: The device (1) according to the invention aims to join at least two medicine capsules (A, B) by adhesive bonding in a reliable and economical manner, in particular in the context of industrial production. To do this, this device comprises at least one matrix (10), which at least partially delimits a recess (15), for depositing capsules (Eight, B), and also a chamber (16), this recess and this chamber being separated from each other by a deformable wall (14) of the matrix, which matrix is designed to move elastically, by pneumatic action of its chamber (16), from a first configuration, in which its recess (15) receives the capsules with a glue (Z) interposed between them, to a second configuration, in which its deformable wall (14) at least partially envelops the capsules by flexible deformation, in such a way as to at least partially enclosed these capsules between the deformable wall and a bottom of the recess in order to align them and press them against one another.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: January 12, 2016
    Assignee: DUO-GE
    Inventors: Mehdi El Glaoui, Guillaume El Glaoui, Jean Hoffelt, Jean-Pierre Fontaine
  • Patent number: 9192693
    Abstract: Disclosed herein is a method for treatment of emphysema by reducing the volume of the pulmonary alveoli or alveolar sacs which have been anomalously expanded with destruction by emphysema. The method includes a step (a) of inserting a catheter into a bronchus or bronchiole, a step (b) of injecting through said catheter a film-forming agent into the respiratory region including the pulmonary alveoli or alveolar sacs, thereby forming a film on the inner wall of said respiratory region, and a step (c) of shrinking said pulmonary alveoli or alveolar sacs.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: November 24, 2015
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yuichi Tada, Takao Anzai, Atsuhiko Nogawa
  • Patent number: 9161557
    Abstract: A dry composition for oral ingestion characterized by comprising as an active ingredient a gas-releasing substance which releases gas by soak with water, and further comprising a gel base in an amount sufficient for gel formation; a gel composition for oral ingestion formed by adding water or a liquid diluent to the dry compound when taking; and a mixed feed obtainable by mixing the gel composition with a feed, are disclosed.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: October 20, 2015
    Assignee: KUREHA CORPORATION
    Inventors: Kazumi Ishii, Saichi Ono, Tadahiko Chiba
  • Patent number: 9155861
    Abstract: A neural drug delivery system with fluidic threads implantable into tissue, including: a plurality of fluid delivery conduits configured to transport fluid and having an array of fluid delivery ports through which the fluid is selectively released; a plurality of port gates each including a mesh structure coupled to a corresponding fluid delivery port and coated with an electroactive polymer; a voltage source providing a conductive signal; and an interconnect network that carries the conductive signal to the port gates. In response of the electroactive polymer to the conductive signal, each port gate is selectively operable between a closed mode that prevents transfer of fluid through its corresponding fluid delivery port to the tissue, and an open mode that allows transfer of the fluid through its corresponding fluid delivery port to the tissue.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: October 13, 2015
    Assignee: NeuroNexus Technologies, Inc.
    Inventors: Jamille F. Hetke, Daryl R. Kipke, Rio J. Vetter
  • Patent number: 9078587
    Abstract: A method for photomagnetic imaging of tissue includes the steps of heating the tissue using light; measuring a change in temperature of the tissue with magnetic resonance thermometry; and creating an optical property map from the measured change in temperature. An apparatus for performing photomagnetic imaging of tissue which includes a light source to heat the tissue, a magnetic resonance imaging system to measure a change in temperature of the tissue, and a data processor to generate an optical property map from the measured change in temperature. An optical property map of tissue photomagnetic imaging of tissue produced by: heating the tissue using light; measuring a change in temperature of the tissue with magnetic resonance thermometry; and creating an optical property map from the measured change in temperature.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: July 14, 2015
    Assignee: The Regents of the University of California
    Inventors: Gultekin Gulsen, David Thayer, Yuting Lin, Mehmet Burcin Unlu
  • Publication number: 20150148782
    Abstract: This present invention provides a delivery device that could be used to delivery discreet small volume of expensive biotechnology treatments to specific areas of the oral cavity, or other tissues. The present invention also provides a method of using the device disclosed herein to deliver biotechnology treatments and/or therapeutic agents to specific areas of the oral cavity, or other tissues. In one embodiment, the treatments and/or therapeutic agents are delivered to the interproximal area between and around the teeth.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 28, 2015
    Inventors: Larry R. Brown, Tyler A. Okel
  • Publication number: 20150148783
    Abstract: An adapter for use in a system for collecting colostrum and/or breast milk may include: a body having a predominantly cylindrical shape; a first open end of the body for connecting to a funnel device; a second open end of the body for connecting to a source of suction; a blocking member inside the body, between the first open end and the second open end; an aperture in the blocking member to allow suction force applied at the second open end to generate suction at the first open end; a reservoir extending off of a side of the body, between the first open end and the blocking member; and a port disposed on the distal end of the reservoir for connecting the adapter to a fluid collection device.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventors: Rush Lloyd BARTLETT, II, Frank T. WANG, Ryan J.F. VAN WERT, Jules P. SHERMAN
  • Patent number: 9039657
    Abstract: Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: May 26, 2015
    Assignee: Acclarent, Inc.
    Inventors: Joshua Makower, John Y. Chang, Julia D. Vrany, Amrish Jayprakash Walke
  • Publication number: 20150141819
    Abstract: A sphenocath including a sheath assembly including a sheath hub with a sheath tube extending therefrom with a passage extending from a proximal end of the sheath hub to a distal end of the sheath tube; a catheter assembly including a catheter hub with a catheter tube extending therefrom with a passage extending from a proximal end of the catheter hub to a distal end of the catheter tube; wherein the catheter assembly passes through the sheath assembly with a portion of the catheter hub engaging a portion of the sheath hub to limit relative rotation between the hubs while permitting relative axial movement such that in an initial non-extended position the distal end of the catheter tube is proximate to the distal end of the sheath tube. A system further including a guidewire is also provided. A method of inserting the catheter tube is also provided.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 21, 2015
    Inventors: Christopher Linden, Frank Debartola, Donald Geer, Kevin E. Sanford, Daryl J. Clark, Timothy M. Schweikert
  • Patent number: 9033953
    Abstract: A suction pump unit comprises a vacuum port, an excess pressure port and a switching valve. The switching valve comprises a valve body with two inputs, wherein a first of the inputs is connected with the vacuum port, and a second of the inputs is connected with the excess pressure port. The switching valve further comprises an output with a through hole, wherein the output can be moved relative to the inputs from the first input to the second input and back, as a result of which the through hole alternately establishes a fluid-communicating connection with one of the inputs. The through hole of the output is released and ventilated during at least part of the movement between the two inputs. This suction pump unit permits passive and active ventilation of an output line connected with the output.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 19, 2015
    Assignee: Medela Holding AG
    Inventor: Armin Felber
  • Publication number: 20150133894
    Abstract: A method of collecting colostrum from a breast of a human and dispensing the colostrum to a newborn may involve: coupling a first end of an adapter with a syringe; positioning a second end of the adapter in contact with or near the breast; manually expressing colostrum from the breast into the second end of the adapter; coupling the second end of the adapter with a breast pump shield; expressing colostrum from the breast, using the breast pump shield and a breast pump system attached to the breast pump shield; retracting a plunger of the syringe to cause the colostrum to move into the syringe from the adapter; detaching the adapter from the first end of the syringe; and dispensing the colostrum to the newborn from the syringe.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 14, 2015
    Inventors: Jules P. SHERMAN, Rush L. BARTLETT, II, Ryan J.F. VAN WERT
  • Publication number: 20150132284
    Abstract: Provided herein are methods of treating and inducing ulcerative colitis in a subject. Also provided are methods of treating subjects with mild to moderate active ulcerative colitis, including ulcerative proctitis and proctosigmoiditis. Also provided are methods of administering budesonide to a subject to treat ulcerative colitis, including ulcerative proctitis and proctosigmoiditis.
    Type: Application
    Filed: October 30, 2014
    Publication date: May 14, 2015
    Inventors: William P. Forbes, Enoch Bortey, Craig Paterson, Pam Golden
  • Publication number: 20150126968
    Abstract: Devices and methods are provided for fluid delivery. The device may include a housing having an outer surface which includes a porous membrane, a fluid reservoir disposed in the interior region of the main housing and formed at least in part by a wall structure, a puncture mechanism operable to puncture the wall structure and form a fluidic path between the fluid reservoir and one or more channels in fluid communication with the porous membrane, and a positive displacement mechanism operable, following puncture of the wall structure, to drive a fluid out of the fluid reservoir, through the one or more channels, and into the porous membrane.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 7, 2015
    Applicant: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventors: Ramkumar Abhishek, Felicia Linn
  • Publication number: 20150119856
    Abstract: An ear medication delivery device for delivering a treatment liquid and retaining the treatment liquid within an ear canal of a patient including a unitary, one piece earplug formed of a soft resilient material including an ear canal engaging portion and an external portion and defining a single internal passage therethrough. The external portion includes a major disk and an annular medication applicator receiving portion in fluid communication with the internal passage. The ear canal engaging portion includes at least two minor disks of progressively different size extending outwardly in a generally radial direction. The ear canal engaging portion defines a molded resilient valve unitary with the earplug that is shiftable from a closed position to an open position in either direction under a preselected fluid pressure and that resiliently returns to the closed position below the preselected fluid pressure.
    Type: Application
    Filed: January 9, 2015
    Publication date: April 30, 2015
    Inventors: Aner Vlodaver, Benhoor Soumekh
  • Publication number: 20150119850
    Abstract: Methods for maintaining patency in a bronchus of a patient are presented. A catheter is positioned within the bronchus. A target region of one or more of a bronchial wall, submucosa, media, and adventitia is punctured at or adjacent a location of a debulked bronchial carcinoma with an injection needle disposed on a distal end of the catheter. Such puncturing is achieved by expanding a balloon disposed on the distal end of the catheter. The balloon is comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. Through the injection needle, an amount of cytotoxic, cytostatic, or anti-neoplastic agent is delivered to the target region. The delivered amount is effective to limit by a therapeutically beneficial amount recurrent bronchial occlusion due to recurrence of the bronchial carcinoma.
    Type: Application
    Filed: October 24, 2014
    Publication date: April 30, 2015
    Inventor: Kirk Patrick SEWARD
  • Patent number: 9017310
    Abstract: Devices and methods for transmucosal drug delivery are provided. A device includes a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject. The device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: April 28, 2015
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters
  • Patent number: 9014799
    Abstract: Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: April 21, 2015
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters, Serena Wong