Abstract: A device that allows for either fat graft preparation or cell fraction harvest is disclosed. The device includes a first centrifuge tube configured to receive and process a biological substance, the first centrifuge tube comprising an upper cylindrical portion and a lower conical portion, a sterile tissue inlet fitting, at least one sterile processing fluid inlet fitting, a sterile suction fitting, and at least one sterile extraction port connected to a first extraction tube. The first centrifuge tube further includes an internal space including a screen being positioned therein, the screen being configured to divide the internal space in half, and a filter positioned therein, the filter being positioned below the screen in the lower conical portion of the first centrifuge tube. The device may further include a second centrifuge tube configured to receive and further process the biological substance from the first centrifuge tube.

Abstract: A sealed assembly for pill crushing and delivering and a method for using thereof are provided. The assembly includes: a connecting valve with different diameters, including a first end, a valve and a second end provided with a syringe-abutting interface, wherein, an opening diameter of the first end is larger than that of the second end; and a pill-crushing carrier including a sealed cavity having only one filling-in opening, the pill-crushing carrier has a first state when separated from the connecting valve and the filling-in opening is exposed for delivering pills into the carrier, and a second state when the filling-in opening is connected to the first end of the connecting valve, crushed and dissolved pill powders in the sealed cavity can be taken out through the connecting valve. The assembly can crush pills and dissolve powders in a sealed cavity, deliver powder-dissolved liquid and prevent powders from dispersing.

Abstract: Disclosed is a medical fluid connector configured to receive and dispense medical liquid. The medical connector can be structured to include an initial stage in which medical liquid is infused into the connector and dispensed out of the connector essentially unchanged. The medical connector also can be structured to include a subsequent stage in which medical liquid is not infused into the connector and a volume of therapeutic liquid is dispensed out of the connector. The therapeutic liquid can include a portion of the volume of the medical liquid that was infused into the connector in the initial stage plus a therapeutic additive.

Abstract: The invention relates to a two-component mixing capsule (1) for intake and for mixing of two, preferably powdered or preferably pasty or kneadable, particularly preferably dental, compositions with a capsule housing (2) having a discharge opening (3) at its front end (2.1), wherein the mixing capsule (1) comprises a first mixing chamber (5a) and a second mixing chamber (5b), wherein the two mixing chambers may be separated from each other for storage or for transport, by the first mixing chamber (5a) being rotated by a rotatably mounted handhold element whose rotation axis (Y) is approximately perpendicularly arranged to the longitudinal axis (Z) of the mixing capsule (1) into a first position in which the first mixing chamber (5a) is separated from mixing chamber (5b), preferably the central axes of the mixing chambers are arranged to each other by approximately 90°.

Abstract: An assembly for mixing and dispensing a multi-component fluid includes a sheath having first and second fluid chambers, a chamber coupler, and a flexible tip. The chamber coupler forms first and second fluid channels. Additionally, the flexible tip forms a mixing chamber with a variable mixing volume and an outlet. The flexible tip is coupled to the chamber coupler near a distal end of the sheath. In the presence of an activation force, the flexible tip is forced out of the sheath and positioned in a dispensing state with a maximum mixing volume. In the absence of the activation force, the flexible tip is housed within the sheath and positioned in a non-dispensing state with a minimum mixing volume such that the outlet is substantially closed.

Abstract: A method for controlling fluid ratio accuracy during a dual flow injection with a powered injection system is described.

Abstract: An alignment assembly for a cartridge interface of a drug delivery device is disclosed. The assembly optionally includes a coupling for opening fluid communication between the cartridge and the delivery device. For example, the coupling optionally includes a cannula insertable through a septum of the cartridge. The assembly may include a guide for positioning the cartridge and/or an access channel thereof within a first precision of a loaded position. The assembly optionally includes a cartridge engagement fitting (for example a gripping expander sleeve collar) attached to the coupling. Optionally when the cartridge is engaged to the fitting, the coupling is retained in connection with the access channel to within a second precision. The second precision is optionally higher than the first precision. In some embodiments one or more compliant supports movably retain the fitting oriented to engage the cartridge when the access channel is in the loaded position.

Abstract: There is provided a pressure oscillation damper in order to reduce the level of the pressure oscillations by the use of for a fluid extraction system. The pressure oscillation damper comprises a wall enclosing a main volume, at least two inlets, arranged in the wall and adapted to be connected to fluid extraction units, at least two outlets, arranged in the wall and adapted to be connected to pumping units, and at least one flexible member, arranged in the first volume so as to divide the first volume into at least two secondary volumes, each secondary volume forming a channel between the at least one inlet and at least one outlet, the flexible member being configured to bend toward a secondary volume having a lower pressure.

Abstract: A coupling mechanism for a medication delivery device includes a first part axially fixed relative to a housing and rotatable around a longitudinal axis of the first part, the first part having a gearing engagement to a second part arranged along the longitudinal axis, the gearing engagement having a first frictional resistance. The second part axially moveable along the longitudinal axis, and directly or indirectly in a friction fit engagement with the housing, which has a second frictional resistance. The first frictional resistance being below the second frictional resistance such that a rotation of the first part in a first direction axially longitudinally moves the second part away from the first part and a rotation in a second direction, opposite to the first rotation direction, reduces the axial distance between the first and second part and/or axially moves the second part into coupling abutment with the first part.

Abstract: The present disclosure relates to a needleless syringe and method for delivering therapeutic particles. A source of therapeutic particles is located between a gas source and a cannon having a side opening. Gas released from the gas source causes a propagation of the therapeutic particles through the cannon. The side opening causes a reduction of a pressure of the gas in the cannon.

Abstract: Provided is an arthritis treatment method and an arthritis treatment system which can be effective for the short-term attainment of a pain relief effect. An arthritis treatment method includes an instrument introducing step of causing at least one instrument having a tubular shape to communicate with a lesion area in which crystal-induced arthritis occurs, and a treatment step of removing a causative agent of the crystal-induced arthritis from the lesion area by perfusion and discharge of a lavage fluid through the instrument.

Abstract: A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.

Abstract: A wet/dry auto-mixing injector having a mixing device containing at least one microfluidic channel for mixing or dissolving a dry component with a wet component stored in the injector device.

Abstract: The infusion pump drug delivery system and corresponding method disclosed herein allow for continuous delivery of a first fluid and/or medicament from a reservoir operably connected to a pump and selective delivery of a second fluid and/or medicament from a separate reservoir, where the second fluid and/or medicament may be delivered sequentially or simultaneously with the first fluid and/or medicament at the command of the user. Both fluids and/or medicaments are delivered via a single dispense interface.

Abstract: The combination (10) of a burette (11) and injection portion (20) and a tube (21) to be connected to a reservoir to drain a liquid therefrom for delivery to the burette (11). The injection port (20) is fixed to a cap (16) of the burette (11) by having an outlet (28) extending to and being secured to an inlet (19) of the burette (11).

Abstract: A method for combining a first liquid component with a second lyo component in a drug mixing apparatus is provided. The method comprises displacing a seal that prevents the first liquid component within a first barrel from coming into contact with the second lyo/liquid component within a second barrel. The method also comprises using an activating mechanism to move the first liquid component from the first barrel through at least one communication channel to an area within the second barrel holding the second lyo component, allowing the first liquid component to mix with the second lyo component to form a medicament. Additionally the method comprises displacing a second seal that prevents a medicament from entering an outlet channel. The method also comprises using the activating mechanism to eject the mixed medicament from the drug mixing apparatus through the outlet channel.

Abstract: A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.

Abstract: The present invention relates to a dual syringe delivery device consisting of three components which when collectively assembled result in the capability of accommodating varying syringe volume sizes.

Abstract: Apparatus and methods for providing a field environment filled proximal chamber of a multi-chamber syringe and for filling a prime-free syringe are disclosed. In addition, methods for resetting valves of a multi-chamber syringe without special tools or insertion of foreign objects into the syringe are disclosed. A valve for interfacing with syringes telescopically inserted into a larger syringe and which are generally used as proximal chambers in multi-chamber syringes used in mixing and serial delivery applications is disclosed. Four embodiments of novel resettable valves are disclosed. Also, a syringe assembly for delivering a saline-dose-saline medication sequence is disclosed.

Abstract: A method of treating onychomycosis and improving nail appearance for persons suffering onychomycosis, including preparing an aqueous solution containing between 0.3% and 28% (3 g/L or 0.049 mole/L and 280 g/L or 4.53 mole/L) boric acid and between 0.1% and 11% (1g/L or 0.0066 mole/L and 110 g/L or 0.072 mole/L) camphor or other terpene, and applying the solution to the affected nails for a period of time between a few seconds up to 30 minutes at least once per day every day for a sufficiently long period of time for the condition to appreciably improve or to resolve.

Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract: The pneumatic system for intussusception treatment, i.e., invagination of a segment of the intestine into an adjacent segment, includes a pressurized gas supply connected to a series of filters, valves, regulators, and sensors connected to a rectal insertion tube to introduce gas at moderate pressure into the intestine of the patient. A computerized control and monitoring subsystem is included. The system preferably includes a heating system to warm the gas as desired. The system also preferably includes an exhaust portion to relieve internal intestinal pressure as required or desired. The exhaust portion of the system preferably includes a filter to absorb undesirable fecal odors that accompany the exhausted gas. At least the rectal insertion tube and the odor filter may be separable from the remainder of the system for convenient disposal. An alarm may be provided to alert the doctor or medical professional of conditions other than normal.

Abstract: A dilution kit for and a method of diluting concentrated solutions used to treat allergic symptoms are disclosed. The dilution kit may comprise a case comprising: a base; and a cover hingedly coupled to the base. A foam pad may be removably coupled within the base, the foam pad defining a plurality of vial apertures. A plurality of vials may be removably positionable within the plurality of vial apertures. The method may comprise: removably positioning at least one of a plurality of vials in an upwardly facing position within at least one of a plurality of apertures defined in a layer of foam padding in a base of a case of a dilution kit; and placing a predetermined amount of one of a diluent, a concentrated solution, and a combination thereof into at least one empty vial of the plurality of vials.

Abstract: A syringe device that includes a stem, container, and a plunger, the plunger having tubes with a soluble substance that maintain a seal on compounds within the container's chamber, and/or a parabolic cover held in position by a soluble substance, thus allowing a multi-cycle usage to dispense medication to patients, even while preventing further use.

Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.

Abstract: A syringe (1) for mixing and ejecting an active pharmaceutical ingredient is disclosed. The syringe (1) comprises a syringe body (2) defining a first lumen (8), a first plunger (4) arranged movably in said first lumen (8), said first plunger (4) being hollow, thereby defining a second lumen (9) being separated from the first lumen (8), and a second plunger (5) arranged movably in said second lumen (9). A liquid diluent is contained in one of the first lumen (8) and the second lumen (9), and an active pharmaceutical ingredient is contained in the other of the first lumen (8) and the second lumen (9). The second plunger (5) is movable in such a manner that the active pharmaceutical ingredient and the liquid diluent are brought together, e.g.

Abstract: A combining syringe wherein multiple fluids are dispensed through a primary plunger into a primary cylinder when a force is applied to the secondary plunger shaft. The fluids are combined and dispensed from the primary cylinder's attaching end when a force is applied to the primary plunger shaft. The primary plunger shaft has a primary plunger attaching end opposite a primary pressure applying end. The primary plunger is connected to the primary plunger attaching end. The primary plunger shaft accepts a secondary cylinder and secures it with an attaching element. The secondary cylinder has a secondary plunger receiving end opposite a dispensing end. The secondary cylinder's dispensing end is inserted into an opening of the primary plunger. The secondary plunger shaft has a secondary plunger attaching end opposite a secondary pressure applying end. The secondary plunger is connected to the secondary plunger attaching end.

Abstract: The invention concerns an assembly for delivering a flowable nutritional substance, e.g. made from homemade cooked foods or home prepared food or foods treated with a hand blender or equivalent, comprising a substantially tubular container 1 formed with enclosed lower end and an open upper end, the open upper end being adapted to receive in a sealing manner a closure 20, the closure comprising a unidirectional valve 18, the container 1 also comprising a fluid outlet port in the form of a valve and a pump mechanism 3 is contained in a pump housing 5.

Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.

Abstract: A syringe-carpule assembly comprising first and second carpules, a housing holding the first and second carpules in an end-to-end relationship, an outer hollow plunger rod supported by and slidable relative to the housing, and an inner hollow rod having first and second openings and being slidably arranged inside the outer hollow plunger rod. The inner hollow rod is slidable between first and second positions. The inner hollow rod in the first position has the first opening disposed within the first carpule and the second opening disposed within the second carpule. This allows liquid solvent in the second carpule to flow into the first carpule, which comprises an evacuated chamber containing solid matter that dissolves in the presence of that solvent to form a mixture. The second carpule is then removed and the mixture in the first carpule is injected into the patient.

Abstract: A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.

Abstract: A system for storing and dispensing first and second fluids. A syringe, including a first fluid chamber, a second fluid chamber, a first outlet communicating with the first fluid chamber and extending along a first axis; a second outlet communicating with the second fluid chamber and extending along a second axis, the second axis spaced from the first axis by a first distance. A container having first and second compartments separated by at least one wall and configured to store the first and second fluids, respectively, the first compartment having a first port positioned to be fluidicly connected with the first outlet and the second compartment having a second port positioned to be fluidicly connected with the second outlet.

Abstract: The invention provides a device and methods suitable for producing a cellular spray of cells. The sprayed cells are of interest for covering and growing on a surface, including a skin wound. In applying the method and/or using the device, cells for grafting onto a patient are dispersed in a solution and sprayed with the device for distribution over the recipient's graft site.

Abstract: A nozzle for the supply of biological material, in particular tissue cells, having a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), at least one nozzle opening (23) which is formed in the distal end surface (22), and at least two supply ducts (30, 40, 50) which discharge into the mixing chamber (11). A first supply duct (30) is arranged in the proximal end surface (21) and discharges into the mixing chamber (11) coaxially to the nozzle opening (23) and a second supply duct (40) has an inlet opening (42) which discharges into the mixing chamber (11) laterally, in particular tangentially at the distal end surface (22).

Abstract: Devices and methods are provided for drug delivery. The device may include a housing having a first compartment containing a drug in a dry, solid form, a second compartment containing a liquid carrier for the drug, and an expansion member located within or adjacent to the first or second compartment. The second compartment may be fluidly connectable to the first compartment by a rupturable barrier or mechanical valve. The device may also include an actuation system configured to expand the expansion member to rupture the rupturable barrier or open the mechanical valve and permit the liquid carrier to flow into the first compartment and mix with the drug to form a reconstituted drug solution.

Abstract: A method for preparing a solution from a solvent and an active substance in and on a disposable injector with a housing, with an at least intermittently fillable cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of the cylinder/piston unit, wherein the container adapter supports a container which can be filled at least temporarily with active substance and which is closable by an openable stopper.

Abstract: An ingestible material delivery device for sequentially delivering first and second ingestible materials to a user through a feeding tube provides a tube body having first and second chambers separated by a seal. A puncture tool is disposed in the second chamber extending toward the seal. The puncture tool engages and disrupts the seal when the second chamber is compressed. In some embodiments, the second chamber includes a plurality of interconnected bellows operable for axial compression of the second chamber. Another embodiment of a delivery device provides a tube body having first and second chambers with exit nozzles extending in opposite flow directions. A method of sequentially delivering first and second ingestible materials to a user through a feeding tube is also provided.

Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.

Abstract: A delivery system comprising a covering having at least two compartments is provided. A first compartment contains a first therapeutic agent and the second compartment can be unfilled and is configured to receive a second therapeutic agent. The first compartment and the second compartment are separated by at least one removable separation member, for example a drawstring, that can be pulled to allow the first and second therapeutic agents to mix prior to delivery at a selected surgical site. Either the first or second compartment of the covering define an opening further comprising a pre-attached sealing member, which can be a flap sealable by heat, sutures, pressing or interference fittings. The opening of the empty compartment can be configured to receive a filling member, such as a funnel fitted with a spring loaded clip for temporary attachment to the covering. A method of treating a bone defect in a patient utilizing the delivery system is also provided.

Abstract: A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.

Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.

Abstract: A fabric medical device and method of making the device can include warp yarns and fill yarns woven together to form a first tubular extent having a first diameter, a second tubular extent having a second diameter, and a transition tubular extent having a graduated diameter between the first and second tubular extents. A tapered edge can be formed along the transition tubular extent by weaving such that a graduated number of warp yarns are disengaged along the transition tubular extent. A seam can be woven along the tapered edge that is configured to provide a substantially fluid-tight transition between the first and second tubular extents. The device can further include the warp yarns in at least the transition tubular extent having a tenacity higher than the tenacity of the fill yarns. The device can be a bone filler delivery device adapted to deliver bone filler in an internal body region.

Abstract: A method of storing and delivery a drug, such as by lyophilizing and reconstituting, comprises performing both storing and delivering with the same container closure assembly. The container closure is assembled in a preparation configuration during which lyophilization occurs. After lyophilizing, the powdered drug is forced into a spiral channel in the container closure assembly by a plunger. The plunger leaves substantially no head space for the powdered drug, and the assembly is sealed thereby now being in the storage configuration. For delivery of the stored powdered drug, a syringe of diluent is introduced to the container assembly thereby changing the assembly to the delivery configuration. The spiral channel is continuous between an input end and a delivery end with the delivery end being in fluid communication with a delivery outlet of the assembly. The assembly includes a diluent flow path that forces the diluent into a spiral channel at only the input end.

Abstract: The present disclosure provides a cannula useful for introducing a thermally responsive polymer in situ. In embodiments, the cannula possesses more than one cannula, with the thermally responsive polymer introduced in one cannula, and a material such as a coolant in a second cannula which prevents premature gelling of the thermally responsive polymer.

Abstract: A combining syringe wherein multiple fluids are dispensed through a primary plunger into a primary cylinder when a force is applied to the secondary plunger shaft. The fluids are combined and dispensed from the primary cylinder's attaching end when a force is applied to the primary plunger shaft. The primary plunger shaft has a primary plunger attaching end opposite a primary pressure applying end. The primary plunger is connected to the primary plunger attaching end. The primary plunger shaft accepts a secondary cylinder and secures it with an attaching element. The secondary cylinder has a secondary plunger receiving end opposite a dispensing end. The secondary cylinder's dispensing end is inserted into an opening of the primary plunger. The secondary plunger shaft has a secondary plunger attaching end opposite a secondary pressure applying end. The secondary plunger is connected to the secondary plunger attaching end.

Abstract: Devices and systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, a joint or intra-articular space, include a handpiece assembly having a needle extending from its distal end, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medicaments, formulations and/or other fluids or materials contained within vials that are secured to a cassette or other portion of the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.

Abstract: A movable mixing disc is inserted into a regular syringe. The mixing disc has a small hole covered by a fine screen, allowing only saline solution to get behind the disc. When the plunger of the syringe is pressed, the saline solution emerges from the mixing disc hole as a high velocity jet, stirring up the settled particles. As the ejection continues, the mixing disc is pushed forward by the plunger in order to eliminate any unused volume.

Abstract: A differential pressure based flow sensor assembly and method of using the same to determine the rate of fluid flow in a fluid system. The sensor assembly comprises a disposable portion, and a reusable portion. A flow restricting element is positioned along a fluid flow passage between an inlet and an outlet. The disposable portion further has an upstream fluid pressure membrane and a downstream fluid pressure membrane. The reusable portion has an upstream fluid pressure sensor and a downstream fluid pressure sensor. The upstream fluid pressure sensor senses the upstream fluid pressure at a location within the fluid flow passage between the inlet and the flow restricting element. The downstream fluid pressure sensor senses the downstream fluid pressure at a location within the fluid flow passage between the flow restricting element and the outlet. The process utilizes output of the sensors to calculate the flow rate of the fluid.

Abstract: An in vivo sensing device and system may contain or be used in conjunction with an image sensor and a body lumen clearing element or agent. A method may enable clearing a body lumen for in vivo sensing while using the device of the invention.

Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.