Means For Placing Solid Treating Material In Body Patents (Class 604/57)
  • Patent number: 11351297
    Abstract: Certain embodiments of a medicinal applicator can comprise a base, a medicinal cream receiving port in the base, and a shaft extending along a conceptual shaft axis from the base and terminating at an applicator tip. There is at least one exit aperture located along a portion of the shaft. An unobstructed pathway is in communication with the receiving port and the exit aperture. A stop plate that extends essentially radially from the base delineating the base from the shaft. The shaft possesses a shaft outer shape defined by a shaped leading and trailing edge defining a narrow diameter proximal zone that extends along the shaft from the stop plate to a gradually increasing diameter transition zone that extends to a large diameter paddle zone, which terminates into a shaft distal end.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: June 7, 2022
    Inventors: Ryan Maaskamp, Armand Maaskamp
  • Patent number: 11337705
    Abstract: An embolization device may include a fiber section having a plurality of polymeric electrospun fibers and, optionally, a contrast agent. An embolization device may further include a plurality of fiber sections, wherein each fiber section is separated by a linker. A method of deploying such an embolization device may include inserting the embolization device into a vessel. The method may further include applying an electrical current to one or more of the linkers, applying electrothermal heat to at least a portion of the device, or applying force to at least a portion of a delivery vehicle for the device. A method of manufacturing the device may include electrospinning a fiber section, and processing the fiber section by straining, twisting, heating, or shaping it.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: May 24, 2022
    Inventors: Jed Johnson, Tyler Groehl, Devan Ohst
  • Patent number: 11331499
    Abstract: A medical implant device (100) is disclosed that can protect and shield an implant (101) as the implant (101) moves through body tissue. The medical implant device (100) can comprise a main body portion (110) having a payload opening (111) to receive a payload (i.e., an implant). The medical implant device (100) can also comprise a tapered nose portion (120) at a front end (103a) of the medical implant device (100) extending from the main body portion (110) and configured to penetrate body tissue. In addition, the medical implant device (100) can comprise a payload coupling interface (130) configured to couple the implant (101) to the main body portion (110).
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: May 17, 2022
    Assignee: University of Utah Research Foundation
    Inventors: David Kluger, Gregory Clark, Douglas Hutchinson, David Page, Suzanne Wendelken
  • Patent number: 11311615
    Abstract: Provided herein are vaccine compositions for example in a dry powder form for intranasal delivery, and their preparation methods. Also provided are methods of using vaccine compositions, for example in stimulating mucosal or systemic immune responses by delivering the vaccine compositions intranasally.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: April 26, 2022
    Inventor: Shunji Haruta
  • Patent number: 11259834
    Abstract: A medical device for treating an aneurysm in a blood vessel includes a hollow shaft for insertion into the blood vessel, an exit port at a distal end of the shaft, a deflection element, and a position sensor. The hollow shaft encompasses a wire-insertion channel for leading a wire to be inserted into the aneurysm. The exit port is configured for exiting the wire from the wire-insertion channel and into the aneurysm. The deflection element is located adjacent to the exit port and configured to deflect the wire from the wire-insertion channel to the exit port. The position sensor, which is coupled to the distal end of the shaft, is configured to produce signals indicative of a position and orientation of the exit port in the blood vessel.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: March 1, 2022
    Assignee: Biosense Webster (Israel) Ltd.
    Inventor: Assaf Govari
  • Patent number: 10898701
    Abstract: A device for the dispensing of liquids is disclosed. In an embodiment the device comprises a first hollow bulb coupled to a second hollow bulb, wherein the first hollow bulb is compressible; and a separator element disposed between the first hollow bulb and the second hollow bulb, wherein the separator element defines a passage; wherein the second hollow bulb defines an opening.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: January 26, 2021
    Assignee: AJB LLC
    Inventor: John L. Boone
  • Patent number: 10857039
    Abstract: A hemostatic device for treatment of a gunshot wound includes a barrel, which has a first end that is open, and a plunger. The barrel is arcuate adjacent to a second end to define a tip section. A clotting medium and a gauze are positioned in the barrel proximate to the tip section and between the clotting medium and the first end, respectively. A plurality of slits that is positioned in the tip section defines a plurality of petals, which comprise plastic and are resiliently deformable. The plunger, which has a head that is sealably positioned in the barrel adjacent to the first end, is configured to be pushed into the barrel to apply pressure to the gauze and the clotting medium so that the petals separate. The clotting medium and the gauze are sequentially expelled from the barrel into a wound to induce clotting and to pack the wound.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: December 8, 2020
    Inventor: H. Chandler Bartholomew
  • Patent number: 10588664
    Abstract: According to embodiments of the present invention, a subcutaneous implant delivery apparatus is provided. The apparatus includes a receiving portion configured to receive a subcutaneous implantable device; and a stabilizing portion configured to cooperate with the receiving portion to hold the subcutaneous implantable device in a fixed position. The receiving portion and the stabilizing portion are movable relative to each other between a released configuration, wherein the receiving portion and the stabilizing portion are configured to move apart from each other to allow the receiving portion to be inserted under a skin layer, and a closed configuration, wherein the receiving portion and the stabilizing portion are configured to move toward each other to allow the subcutaneous implantable device to be held adjacent to the skin layer. According to further embodiments of the present invention, a method of delivering a subcutaneous implantable device for accessing a vascular site is also provided.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: March 17, 2020
    Assignee: Agency for Science, Technology and Research
    Inventors: Soo Ghim Lim, Ruey Feng Peh, Yee Han Kuan, Yanling Toh
  • Patent number: 9867622
    Abstract: A system and method of delivering and detaching an implant within a body of a patient is described. A tether connects an implant with a delivery device. The delivery device includes a heater through which the tether passes. The inner lumen of the delivery system pusher may accommodate the lead wires which connect to the heater.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: January 16, 2018
    Assignee: MicroVention, Inc.
    Inventor: Heath Bowman
  • Patent number: 9788840
    Abstract: An intracorporeal space filling device and a delivery system and method for using the device is disclosed. The space filling device is preferably configured for percutaneous delivery from a peripheral conduit of a patient. The space filling device has an elongated tubular or interconnected bead structure which may have a transmutable material disposed within it. The transmutable material can be altered from a non-rigid state to a rigid state by the application of various types of energy or by other suitable means. The space filling device can be positioned by a delivery system and detached from the delivery system after desired positioning is achieved.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: October 17, 2017
    Inventor: Michael P. Marks
  • Patent number: 9781944
    Abstract: A lollipop ball is formed to a lollipop ball engagement mechanism and the lollipop ball engagement mechanism extends outward from the lollipop ball to releasably engage a proximal end of a lollipop stick. Alternatively, a lollipop ball is formed to a lollipop ball engagement mechanism that defines a cavity inside the sphere of the lollipop ball and the proximal end of the lollipop stick releasably engages the cavity located in the interior of the lollipop. Alternatively, the lollipop itself can be formed to define the cavity such that no lollipop ball engagement mechanism is required to releasably engage the proximal end of the lollipop stick. The lollipop stick can also include one or more design elements.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: October 10, 2017
    Assignee: SUGAR FACTORY, LLC
    Inventor: Steve Davidovici
  • Patent number: 9603600
    Abstract: Systems and methods are provided for using an actuator to deploy an implant configured to close a tissue puncture or a natural opening in a body. The actuator includes a handle that is rotated in a first direction to deploy a first set of deployable wings of the implant, and that is rotated in a second, opposite direction to deploy a second set of deployable wings of the implant. A guide wire coupled between the implant and the actuator rotates and/or moves axially with the actuator to cause the wings to deploy. After each of the first and second rotation strokes, the handle is prevented from rotating beyond the first and second strokes, respectively. After the wings are deployed to engage tissue therebetween, the handle is operated to eject the implant from the actuator.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: March 28, 2017
    Inventors: James E. Coleman, Christy Cummins
  • Patent number: 9180006
    Abstract: A device for improving the function of a heart valve comprises a first loop-shaped support, which is configured to abut a first side of the heart valve, and a second loop-shaped support, which is configured to abut a second side of the heart valve opposite to said first side, whereby a portion of the valve tissue is trapped between the first and second supports. An outer boundary of the second support is greater than an outer boundary of the first support.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: November 10, 2015
    Assignee: Medtentia AB
    Inventor: Olli Keränen
  • Patent number: 9033912
    Abstract: A drug delivery device for delivering a drug pellet to a site beneath the skin of a patient is provided, the drug delivery device including a housing having a chamber configured to hold at least one drug pellet, the chamber having a loading end and a delivery end, the loading end of the chamber having an opening for receiving a plunger and a drug pellet and the delivery end having an opening for receiving the plunger and passage of the drug pellet. The housing includes at least one hole substantially perpendicular to the chamber and formed to at least partially intersect the chamber. A capture pin is provided configured to be receivable within the at least one hole.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: May 19, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20150119796
    Abstract: The present teachings provide thread attachment mechanisms each having an internal and an external threaded portion. The internal and external threaded portions are configured to engage with each other to form an attachment. The thread attachment mechanism in the present teachings further include an anti-lockup feature. The present teachings further provide a cardiac implant engaged with a delivery catheter devices through a thread attachment mechanism having an anti-lockup feature of the present teachings. In one embodiment, the anti-lockup feature prevents the implant from being overly tightened to the delivery catheter. In another embodiment, the anti-lockup feature allows the implant to be released from the delivery catheter in a predictable and controlled manlier. Another aspect of the present teachings provides methods of using a threaded attaching mechanism of the present teachings to deliver, deploy, and release a cardiac implant.
    Type: Application
    Filed: October 26, 2014
    Publication date: April 30, 2015
    Applicant: DC Devices, Inc.
    Inventor: Matthew J. Finch
  • Publication number: 20150100040
    Abstract: A medical material supply device which can percutaneously supply a material for nerve regeneration that promotes the regeneration of a nerve is insertable into a vessel and includes: a supply section configured to penetrate from an inner wall to an outer wall of the vessel at a predetermined position in the vessel, thereby being able to supply a material for nerve regeneration to the outer wall of the vessel; and an elongated body which is inserted into the vessel, in which the supply section is provided with a linear portion which is provided at the elongated body and is configured to penetrate from the inner wall to the outer wall of the vessel.
    Type: Application
    Filed: October 8, 2014
    Publication date: April 9, 2015
    Inventors: Risato KOBAYASHI, Ichirou HIRAHARA
  • Publication number: 20150080855
    Abstract: Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
    Type: Application
    Filed: September 17, 2013
    Publication date: March 19, 2015
    Applicant: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, SR.
  • Publication number: 20150080659
    Abstract: Systems and methods provide intraluminal delivery of a bandage structure within a body lumen or hollow body organ, e.g., for treating an injured gastrointestinal tract or an esophageal hemorrhage in a non-invasive way using endoscopic visualization. The systems and methods can be sized and configured to apply a chitosan bandage structure within a body lumen or hollow body organ, to take advantage of the mucoadhesive, antimicrobial, hemostatic, and potential accelerated wound healing properties of the chitosan material.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Inventors: Kenton W. Gregory, Amanda Dayton (formerly Senrud)
  • Patent number: 8979821
    Abstract: A biomaterial mass is inserted through a punctum into a canaliculus in the lacrimal outflow system with a syringe. The mass has an outer cross section that is less than the inner cross section of the canaliculus. The mass absorbs liquid to swell to form a lacrimal filler or sealing mechanism. The lacrimal filler has an external cross section that conforms to the internal cross section of the canaliculus and a soft outer surface relative to the surrounding tissues to prevent erosion of the canaliculus lining. The lacrimal filler forms an occlusion that prevents the outflow of liquid through the lacrimal outflow system to retain tears within the eye to maintain eye lubrication and wetness. The mass and syringe are provided in kit with a rubber stopper and, optionally, a punctal dilator, an injecting catheter, and an enzyme for dissolving or degrading the lacrimal filler at a later time.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: March 17, 2015
    Assignee: Fezza Family Properties, LLC
    Inventor: John Fezza
  • Patent number: 8911425
    Abstract: Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: December 16, 2014
    Assignee: Medimetrics Personalized Drug Delivery
    Inventors: Johan Frederik Dijksman, Anke Pierik, Jeff Shimizu, Hans Zou
  • Patent number: 8888745
    Abstract: The invention pertains to an applicator (1) for inserting an implant, in particular a rod-like implant (2) containing an active substance, under the skin of a human or animal, comprising a housing (3), a cannula (6) extending from the housing (3), and a handle (15) for grasping and maneuvering the applicator (1) and the cannula (6) during insertion of an implant (2). In accordance with the invention, the handle (15) extends above at least part of the length of the cannula (6). Such a handle facilitates insertion of the cannula and/or accurate positioning of the implant.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: November 18, 2014
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Iris Epkjen Hobo Van Der Graaf, Maurice Petrus Wilhelmus Tak, Juergen Schmidt, Hendricus Johannes Vertegaal
  • Patent number: 8877233
    Abstract: Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: November 4, 2014
    Assignee: Cook Biotech Incorporated
    Inventors: Joseph Obermiller, Michael C. Hiles
  • Publication number: 20140303597
    Abstract: A device and method for administering a dose of particulate solid medication to a nursing age infant or child through a tube having one end held in a nursing nipple. The tube is held in a holder piece which also mounts the nipple aligned with the tube. The tube is resiliently bendable to hold the dose of medicine loaded therein prepatory to being released to pass down to said nipple. A child having the nipple in his or her mouth reflexively swallows the medicine passing out of the nipple.
    Type: Application
    Filed: April 3, 2013
    Publication date: October 9, 2014
    Inventor: Tim Platt
  • Patent number: 8855746
    Abstract: An endoscopic medical tool is endoscopically inserted into a body cavity in order to eject a member into the body cavity, and includes: a flexible sheath having an inner cavity; an elastically deformable stopper which is provided projecting out toward the inner cavity in a distal end portion of the sheath, and prevents the member which has been loaded inside the sheath from falling out of the sheath; and a pusher which is inserted into the sheath in a freely advancing and retracting manner, and which pushes out and ejects the member from the sheath. In the endoscopic medical tool, the stopper is formed in only a partial region of the inner cavity so that the stopper does not continuously formed over the entire circumference of the inner cavity.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: October 7, 2014
    Assignee: Olympus Medical Systems Corp.
    Inventor: Masaru Yuasa
  • Publication number: 20140276636
    Abstract: Implantable drug delivery devices include a housing having a closed drug reservoir lumen bounded by a first wall structure and a hydrophilic second wall structure, and a drug contained in the drug reservoir lumen, wherein the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug. Methods of providing controlled release of drug to a patient include deploying a drug delivery device in the patient releasing a drug from the drug reservoir lumen via diffusion through the second wall structure.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Inventors: Heejin Lee, Karen Daniel, Matthew Sansone
  • Patent number: 8828050
    Abstract: Embodiments herein comprise a hemostatic composition comprising a plurality of liquid expandable articles capable of expanding upon contact with a liquid. A suitable composition comprises a plurality of liquid-expandable articles that may be mechanically uncoupled from one another and therefore may be capable of moving independently from one another. The plurality of liquid-expandable articles may comprise a compressed material capable of a high-degree of expansion upon liquid contact.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: September 9, 2014
    Assignee: Oregon Biomedical Engineering Institute
    Inventors: Kenton W. Gregory, Lauryn L. Baranowski, Arjun Kalyanpur, Seanna Vine, Grant Blackwell, Benjamin Margolis, Steven Dell
  • Patent number: 8808156
    Abstract: The present invention relates to an applicator for delivering any of a plurality of predetermined radiation fields to a target in intraoperative radiotherapy. In a variant, the applicator comprises: a panel and at least one first pair of first and second grippers pivotally connected to the panel with each gripper having loop on an end. The loop is connected to an arm and the arm pivotally attached to the panel. The first and second grippers are configured to rotate in opposite directions to form an open position and come to a stopping point. The loops of the grippers are configured to slide under one another while rotating into a retracted configuration. Two end units are disposed on opposite ends of the panel, configured for being grasped by two independent graspers for fixing the applicator in position.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: August 19, 2014
    Inventors: Loren Godfrey, Jr., Loren Godfrey, Sr.
  • Publication number: 20140221981
    Abstract: Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.
    Type: Application
    Filed: March 25, 2014
    Publication date: August 7, 2014
    Applicant: TARIS Biomedical, Inc.
    Inventors: Michael J. Cima, Heejin Lee
  • Patent number: 8790293
    Abstract: Disclosed herein is an injector device for delivering an implant, the device including a retracting element, a cannula needle, and a plunger. The device may comprise an latch that, when actuated by a user, causes the retracting element to move the cannula needle away from the delivery site, allowing the plunger to eject the implant into the site. The device may be configured for intraocular drug delivery.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: July 29, 2014
    Assignee: pSivida US, Inc.
    Inventors: Martin Nazzaro, Josh York, Ron LeBlanc
  • Patent number: 8753308
    Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 17, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
  • Patent number: 8734430
    Abstract: The invention relates to an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral. The capsule can have a dissolvable overcap molded from plasticized starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule. A piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen. After insertion of the capsule in the animal the overcap (if present) dissolves and separates from the capsule to release the dump dose of medicament. The sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present).
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: May 27, 2014
    Assignee: Merial Limited
    Inventor: Robert William Lachlan Holmes
  • Patent number: 8721621
    Abstract: A method delivers an implantable device through the urethra and into the bladder. A deployment instrument is inserted into the urethra, the implantable device is inserted into the deployment instrument, and a stream of fluid is injected into the deployment instrument. The stream of fluid drives the implantable device from the deployment instrument into the bladder. The deployment instrument is removed from the urethra, leaving the implantable device wholly implanted in the bladder.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: May 13, 2014
    Assignee: TARIS Biomedical, Inc.
    Inventors: Jim Boyko, Grace Kim, Heejin Lee, Michael J. Cima, Jennie Kwo
  • Patent number: 8715223
    Abstract: Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: May 6, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8715706
    Abstract: A device for drug delivery to an orifice of a subject, comprising a shell which is elastically stressed by an active pharmaceutical ingredient, said shell containing and being substantially impermeable to said active pharmaceutical ingredient, wherein said shell has at least one hole sized for in-vivo release of said active pharmaceutical ingredient as a result of elastic stressing.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: May 6, 2014
    Assignee: RDD Pharma, Ltd.
    Inventor: Nir Barak
  • Patent number: 8702677
    Abstract: Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: April 22, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Thomas A. Simonton, Sean M. Haddock, John Myers Zanella, William F. McKay
  • Patent number: 8697044
    Abstract: The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: April 15, 2014
    Assignee: Allergan, Inc.
    Inventors: Jacqueline A. Schroeder, Gregory S. Dapper, Kenneth C. Olson
  • Publication number: 20140094767
    Abstract: A needle shell is inserted through skin with a needle insert within the needle shell occluding an insertion end of the needle shell. The needle insert is withdrawn from the needle shell and an implant tube is inserted into the needle shell and below the skin. An implant insertion rod is inserted into the needle shell to implant an implant below the skin.
    Type: Application
    Filed: October 2, 2012
    Publication date: April 3, 2014
    Inventors: Robert F. Wallace, Matthew Q. Shaw
  • Patent number: 8617097
    Abstract: An implantable drug-delivery sleeve for an elongate component of an implantable medical device. The sleeve includes a tubular substrate having a lumen configured to receive the elongate component so as to allow relative displacement of the substrate and the elongate component, wherein the substrate is shaped so as to be retained stationary at a desired position along the elongate component, and a drug releasably carried by the substrate.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: December 31, 2013
    Assignee: Cochlear Limited
    Inventors: Fysh Dadd, Jane Rapsey, Peter Gibson, Peter Schuller, Carrie Newbold
  • Publication number: 20130338575
    Abstract: A closure piece for a powder syringe has a main body and a sealing element. The sealing element is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe when the closure piece is disposed in the closing position thereof on the powder syringe. A channel passes through the main body and the sealing element and has a proximal and a distal end. The closure piece includes a retaining element configured and/or disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially prevented from penetrating the channel when the closure piece is disposed in the closing position thereof on the powder syringe.
    Type: Application
    Filed: February 23, 2012
    Publication date: December 19, 2013
    Inventors: Joachim Glocker, Tilman Roedle
  • Patent number: 8603512
    Abstract: Methods and apparatus are provided for treating an injured or severed nerve pathway, wherein one or more microporous tubes are implanted into the nerve pathway to bridge the injured or severed region. A bioactive matrix including stem cells and nutrients is disposed within the microporous tube to facilitate growth of the stem cells and reestablishment of the sensory and motor conductive pathways through the injured or severed region. The microporous tube protects the bioactive matrix during development of the stem cells, and also retains the end regions in proper alignment during the nerve pathway regeneration.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: December 10, 2013
    Assignee: Nexeon Medsystems, Inc.
    Inventor: Mark C. Bates
  • Patent number: 8579852
    Abstract: Methods and devices to process harvested skin tissue and to immediately reintroduce the ground tissue into the patient to repair a tissue defect are disclosed. A hand-held portable tissue grinder comprising a housing and a grinding element are disclosed. The tissue grinder is used for grinding skin and subcutaneous tissue and includes a sterile polymer housing having a first opening adapted to receive the skin and subcutaneous tissue. The tissue grinder also includes a sterile grinding element disposed substantially within the housing. The grinding element includes a plurality of cutting surfaces adapted to operably engage with the housing to provide ground tissue and further includes a handle mechanism coupled to the grinding element to move the grinding element with respect to the housing to grind the skin and subcutaneous tissue, wherein the ground tissue can be removed from the housing.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: November 12, 2013
    Inventor: Omeed Memar
  • Patent number: 8574189
    Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 5, 2013
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
  • Patent number: 8574188
    Abstract: The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient; to a throwaway or reusable device for delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient in a manner as set out by the method; to a pioneer projectile for use in said method; to formulations for use in said method and to an injectate comprising a pioneer projectile and formulation. It also relates to a disposable component containing either a pioneer projectile or an injectate. The invention also relates to a throwaway or reusable device for delivering at least one therapeutic compound, or a formulation comprising the at least one therapeutic compound (hereafter drug) to a patient, and a method for administering a drug to a patient using said device.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: November 5, 2013
    Assignee: Glide Pharmaceutical Technologies Limited
    Inventors: David Stuart Potter, Charles David Ogilvy Potter
  • Patent number: 8568374
    Abstract: An intrauterine system is disclosed for use in the treatment of dysfunctional uterine bleeding; menorraghia; dysmenorrhoea; endometriosis; uterine fibroids; climacteric complaints; osteoporosis; and urogenital atrophy. The system is formed by a frame defining an interior space for receipt of a deposit of a therapeutically effective dose of a biologically active compound. The frame has an open structure allowing access to a substantial part of an outer surface of the deposit, and the deposit has a rate controlling structure that controls a rate of release of the compound within the uterus. One or more retention elements are provided on the frame for retaining the frame within the uterus of a female mammal.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: October 29, 2013
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Wouter De Graaff, Harm Veenstra, Titia Martine Truce Mulders
  • Publication number: 20130267931
    Abstract: Disclosed herein is an injector device for delivering an implant, the device including a retracting element, a cannula needle, and a plunger. The device may comprise an latch that, when actuated by a user, causes the retracting element to move the cannula needle away from the delivery site, allowing the plunger to eject the implant into the site. The device may be configured for intraocular drug delivery.
    Type: Application
    Filed: February 8, 2013
    Publication date: October 10, 2013
    Applicant: PSIVIDA US, INC.
    Inventors: Martin Nazzaro, Josh York, Ron LeBlanc
  • Publication number: 20130267928
    Abstract: Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and/or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 10, 2013
    Applicant: Incube, LLC
    Inventors: Mir Imran, Phillip Morgan, Ben Tranchina, Paul Spher, Kyle Horlen
  • Patent number: 8545377
    Abstract: A magazine for chain components of a chain with radiation sources comprises a housing as well as a first means for receiving chain components that is mounted in a pivotal manner in the housing and has recesses for receiving the chain components, a tension spring for driving the means for receiving the chain components, a sprocket being coupled in a pivotal manner to the means for receiving the chain components and being mounted in a pivotal position in the housing, and an ejector for ejection of the radiation sources. Furthermore, the magazine comprises an ejection lever which is mounted in a pivotal manner in the housing, whereby, in a first position, the ejection lever engages the sprocket, and in a second position it blocks the ejector.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: October 1, 2013
    Assignee: Eckert & Ziegler Bebig GmbH
    Inventors: Axel Hentrich, Christoph Lederer
  • Publication number: 20130245606
    Abstract: A hydrogel based occlusion system, a method for occluding vessels, appendages or aneurysms, and a method for hydrogel synthesis are disclosed. The hydrogel based occlusion system includes a hydrogel having a shrunken and a swollen state and a delivery tool configured to deliver the hydrogel to a target occlusion location. The hydrogel is configured to permanently occlude the target occlusion location in the swollen state. The hydrogel may be an electro-activated hydrogel (EAH) which could be electro-activated with a delivery system to control the degree of swelling/shrinking.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 19, 2013
    Inventors: Frank Albert STAM, Nathan JACKSON, Peter DUBRUEL, Kehinde ADESANYA, Anika EMBRECHTS, Eduardo MENDES, JR., Hurcules Pereira NEVES, Paul HERIJGERS, Peter VERBRUGGHE, Yosi SHACHAM, Leeya ENGEL, Viacheslav KRYLOV
  • Patent number: 8535701
    Abstract: The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: September 17, 2013
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: John R. Peery, Keith E. Dionne, Felix A. Landrau, Bonnie J. Eckenhoff, Scott D. Lautenbach, Judy A. Magruder, Jeremy C. Wright
  • Patent number: 8529550
    Abstract: Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: September 10, 2013
    Assignee: BioCardia, Inc.
    Inventors: Daniel C. Rosenman, Peter A. Altman, Mark A. Lovich, Michael A. Schwartz, Aaron J. Miller