Powder Dispenser Patents (Class 604/58)
  • Patent number: 10918827
    Abstract: A catheter includes an elongated tube having a distal portion having a distal end and a sidewall defining at least one drainage lumen. The sidewall includes a drainage portion which allows fluid to pass through the sidewall and into the drainage lumen. The catheter also includes a permeable tissue support. The tissue support is configured to be deployed in the urinary tract to maintain the distal end of the elongated tube at a predetermined position in a bladder, a ureter, a renal pelvis, or a kidney of the patient. When deployed, the permeable tissue support defines a three-dimensional shape of sufficient size to permit flow of at least a portion of fluid from the urinary tract through the tissue support and drainage portion of the elongated tube to the at least one drainage lumen.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: February 16, 2021
    Inventors: John R. Erbey, II, Jacob L. Upperco, David E. Orr, Andrew Wilbourn, Daisy Smith, Colin M. Huber, Morgan Hinchey
  • Patent number: 10869964
    Abstract: The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. An inner shaft having a distal end is slidable between a first position in which the distal end of the inner shaft is disposed in the barrel and a second position in which the distal end of the inner shaft extends past an opening in the end of the barrel. A tip containing a medicament is disposed about the opening of the elongated barrel. The tip includes at least one aperture for dispensing the medicament. One can inject the medicament from the tip into a bone fracture or degenerative bone tissue during surgery by actuating the trigger of the bioinjection device. A configurable tip may be employed to control the amount and direction of dispersion of such medicament.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: December 22, 2020
    Inventors: Clifford T. Solomon, Theodore C. Solomon
  • Patent number: 10350157
    Abstract: The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 ?m, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: July 16, 2019
    Assignee: ALEXZA PHARMACEUTICALS, INC.
    Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Amy T. Lu, Daniel J. Myers, Joshua D. Rabinowitz, Martin J. Wensley, Jeffrey A. McKinney, Alejandro C. Zaffaroni
  • Patent number: 10220164
    Abstract: A delivery device is provided which has a container containing a dose of a powder, a chamber adapted to receive the container, at least one gas inlet by which gas may enter the chamber, and at least one gas outlet by which gas and entrained powder may exit the chamber for inhalation. The delivery device has a pre-use configuration in which the container is accommodated, at least partially, within a storage enclosure in a wall of the chamber. The delivery device has a deployment member adapted to put the delivery device in an operative configuration by displacing the container from the storage enclosure into the chamber, such that the container is movable within the chamber, in use, the deployment member being adapted to at least partially occupy the storage enclosure in the operative configuration.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: March 5, 2019
    Assignee: Pharmaxis Ltd.
    Inventors: Philip Seeney, Douglas Ivan Jennings
  • Patent number: 9713682
    Abstract: The invention relates to a device 1 for dosing and dry nebulization of nebulizable material 12 chosen from the group comprising anti-infective agents and immunomodulators, comprising a nebulization channel 3, which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve 16 for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir 10 open only towards the nebulization channel, which contains the nebulizable material 12, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: July 25, 2017
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Klaus Eistetter, Wilhelm Wurst, Gerhard Pohlmann, Horst Windt, Oliver Nolte, Wolfgang Koch
  • Patent number: 9205207
    Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: December 8, 2015
    Inventor: Xin Ji
  • Publication number: 20150133780
    Abstract: Embolization particles can be safely delivered to the left gastric artery of a patient by introducing the distal end of a catheter in the patient's left gastric artery, inflating a balloon located near the distal end of the catheter so that the balloon prevents blood from flowing through the left gastric artery, and injecting a mixture of particles and contrast agent into the proximal end of the catheter so that they flow through the catheter. In addition, a path is provided for blood to flow into the catheter through an opening in the sidewall of the catheter at a position that is proximal to the balloon, and out through the distal end of the catheter. This blood flow helps to carry the particles along to their destination in the distal portion of the left gastric artery. The particles are also prevented from flowing into portions of the patient's artery system that are proximal of the balloon.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Inventors: Nickolas Kipshidze, Ronald Jay Solar
  • Publication number: 20150112251
    Abstract: A cartridge for delivery of a material therefrom which has a corrugated portion to allow for bending/extending to be applied to the device from which a material to be deposited can be dispensed. The bendability and extendibility allow for greater efficiency in use and application of the material into cavities, pockets, and/or crevices where one needs to deposit the material.
    Type: Application
    Filed: October 22, 2013
    Publication date: April 23, 2015
    Applicant: Profounda, LLC
    Inventors: Todd Ewen MacLaughlan, Vinit Gopal Kathardekar, Amanullah Abdulhamid Vazir
  • Publication number: 20150101595
    Abstract: A piercing device for use in internally pierced blister delivery devices include a base, a piercer body and an internal fluid path. The internal fluid path includes one or more inlet channels into a central cavity which is connected to one or more delivery channels and exit ports. The cavity is defined by angular walls and top to create turbulence in the fluid flow and to produce a controllable spray, mist, drops, plume or stream delivery. The piercer body also provides a pointed lancet disposed in the center of the exit ports for piercing the lidstock of a formed blister.
    Type: Application
    Filed: October 15, 2014
    Publication date: April 16, 2015
    Applicant: MYSTIC PHARMACEUTICALS, INC.
    Inventors: Jesse Ryan Hancock, Michael Shaw
  • Publication number: 20150094649
    Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. A container holds the therapeutic agent and a pressure source has pressurized fluid in selective fluid communication with at least a portion of the container. A catheter, in fluid communication with the container, has a lumen sized for delivery of the therapeutic agent to a target site. In one embodiment, a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1, and a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 2, 2015
    Applicant: Cook Medical Technologies LLC
    Inventor: Shaun D. Gittard
  • Publication number: 20150018800
    Abstract: Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Inventors: Philippe Reb, Peter C. Sutcliffe
  • Patent number: 8920364
    Abstract: A biomaterial delivery device includes an elongated handheld powder storage conduit with proximal and distal ends and a bore having a central axis. The proximal end is closed by a movable powder dispensing actuator, and the distal end is closed by an openable sealing nib moveable from its closed to its open position by force upon the actuator. The distal end has a distally-projecting powder discharge chute that spaces the nib away from a surgical site. When the device is held upright over a surgical site with the nib opened, powder passing the nib is deflected at a first oblique direction with respect to the central axis and into or onto the powder discharge chute, and powder striking the chute is deflected at a rotationally distinct second oblique direction orientation with respect to the central axis and into or onto the surgical site.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: December 30, 2014
    Assignee: Medtronic Xomed, Inc.
    Inventors: Phillip J. Berman, Matthew J. Friend, Ethan G. Sherman
  • Publication number: 20140377362
    Abstract: Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Mohan Prasad Pahari, Giacomo Basadonna, Denny Lo
  • Patent number: 8911425
    Abstract: Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: December 16, 2014
    Assignee: Medimetrics Personalized Drug Delivery
    Inventors: Johan Frederik Dijksman, Anke Pierik, Jeff Shimizu, Hans Zou
  • Publication number: 20140363513
    Abstract: The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two different linear polylactide-co-glycolide polymers (PLGAs).
    Type: Application
    Filed: August 25, 2014
    Publication date: December 11, 2014
    Applicant: Novartis AG
    Inventors: Markus Ahlheim, Holger Petersen
  • Publication number: 20140364837
    Abstract: There is described a dry powder medicament delivery device comprising: a medicament container containing a unit dose of dry powder medicament; a medicament dispensing assembly; and optionally an air source.
    Type: Application
    Filed: December 14, 2012
    Publication date: December 11, 2014
    Inventors: Robert Nichol Boyes, Philip Wilson Braithwaite
  • Publication number: 20140316369
    Abstract: Embodiments include particle delivery devices and systems and methods of delivering particles to a site. The device and system embodiments include a suspension reservoir which might be a syringe for temporarily storing and delivering a particle suspension. The particle delivery device also includes a mechanical linkage or other structure which allows the suspension reservoir to rotate or otherwise be moved with respect to, or about, a reservoir axis. Rotation or other movement of the suspension reservoir provides a means for maintaining the particles in suspension during particle storage, loading and delivery processes.
    Type: Application
    Filed: November 13, 2012
    Publication date: October 23, 2014
    Inventors: Christopher J. Centeno, Brian Leach
  • Patent number: 8845578
    Abstract: A biomaterial delivery device includes an elongated handheld powder storage conduit with proximal and distal ends and a bore having a central axis. The proximal end is closed by a movable powder dispensing actuator, and the distal end is closed by an openable sealing nib moveable from its closed to its open position by force upon the actuator whether or not the distal end is in contact with a surface. The conduit contains finely-divided loosely-filled powdered sterile biomaterial and a plurality of powder-contacting clump-disrupting projections arrayed inside and along the length of the conduit between the actuator and the nib. The projections are movable in the direction of the central axis by force upon the actuator, and the device when held upright with the nib opened provides a path along which powder may fall past the projections to be gravitationally dispensed in non-atomized form.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: September 30, 2014
    Assignee: Medtronic Xomed, Inc.
    Inventors: Ethan G. Sherman, Matthew J. Friend, Phillip J. Berman
  • Publication number: 20140288491
    Abstract: A composition for use in the treatment of fistula, the composition comprising activated carbon.
    Type: Application
    Filed: October 3, 2012
    Publication date: September 25, 2014
    Applicant: FERRING B.V.
    Inventors: Søren Halskov, Mats Ekelund
  • Patent number: 8834411
    Abstract: A medical device for topical, intranasal or oral administration of dry powder medical compositions includes a unit dose blister form containing an internal piercing device that provides for agitation, dispersion and dispensation of the powder to a user.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: September 16, 2014
    Assignee: Mystic Pharmaceuticals, Inc.
    Inventors: Christopher D. Shay, Timothy R. Sullivan
  • Patent number: 8827946
    Abstract: Formulations and methods of manufacture are provided for granisetron dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations. Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: September 9, 2014
    Assignee: Shin Nippon Biomedical Laboratories, Ltd.
    Inventors: Tatsuo Tsutsui, Ryoichi Nagata, Shunji Haruta
  • Patent number: 8827980
    Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: September 9, 2014
    Inventor: Xin Ji
  • Publication number: 20140243791
    Abstract: A biomaterial delivery device includes an elongated handheld powder storage conduit with proximal and distal ends and a bore having a central axis. The proximal end is closed by a movable powder dispensing actuator, and the distal end is closed by an openable sealing nib moveable from its closed to its open position by force upon the actuator whether or not the distal end is in contact with a surface. The conduit contains finely-divided loosely-filled powdered sterile biomaterial and a plurality of powder-contacting clump-disrupting projections arrayed inside and along the length of the conduit between the actuator and the nib. The projections are movable in the direction of the central axis by force upon the actuator, and the device when held upright with the nib opened provides a path along which powder may fall past the projections to be gravitationally dispensed in non-atomized form.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 28, 2014
    Applicant: Medtronic Xomed, Inc.
    Inventors: Ethan G. Sherman, Matthew J. Friend, Phillip J. Berman
  • Publication number: 20140243794
    Abstract: A device for delivering a dose of medicament comprising activated carbon particles to a patient's rectal cavity has a rectally-insertable cannula. The cannula has a proximal opening, a distal opening and a cavity defined between the proximal and distal openings for containing the medicament. An openable closure spans the proximal opening of the cannula. An actuation means is arranged to drive a volume of fluid, for example water or air, through the cannula cavity to flush the dose of medicament through the distal opening of the cannula.
    Type: Application
    Filed: October 3, 2012
    Publication date: August 28, 2014
    Applicant: FERRING B.V.
    Inventors: Søren Halskov, Lars Svensson
  • Publication number: 20140243792
    Abstract: A biomaterial delivery device includes an elongated handheld powder storage conduit with proximal and distal ends and a bore having a central axis. The proximal end is closed by a movable powder dispensing actuator, and the distal end is closed by an openable sealing nib moveable from its closed to its open position by force upon the actuator. The distal end has a distally-projecting powder discharge chute that spaces the nib away from a surgical site. When the device is held upright over a surgical site with the nib opened, powder passing the nib is deflected at a first oblique direction with respect to the central axis and into or onto the powder discharge chute, and powder striking the chute is deflected at a rotationally distinct second oblique direction orientation with respect to the central axis and into or onto the surgical site.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 28, 2014
    Applicant: Medtronic Xomed, Inc.
    Inventors: Phillip J. Berman, Matthew J. Friend, Ethan G. Sherman
  • Patent number: 8753308
    Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: June 17, 2014
    Assignee: AcelRx Pharmaceuticals, Inc.
    Inventors: Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
  • Patent number: 8728032
    Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. The systems generally comprise a container for holding a therapeutic agent, and a pressure source configured to be placed in selective fluid communication with at least a portion of a reservoir of the container. In one embodiment, fluid from the pressure source is directed through a first region of the container in a direction towards a second region of the container. The fluid then is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site. In alternative embodiments, the fluid from the pressure source may be directed through the second region of the container in a direction towards the first region of the container.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: May 20, 2014
    Assignee: Cook Medical Technologies LLC
    Inventors: Richard W. Ducharme, David E. Sugg, Eugene Skelton, Martin Bruggemann, Lyndsey Bryce
  • Patent number: 8721582
    Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: May 13, 2014
    Inventor: Xin Ji
  • Patent number: 8696616
    Abstract: Methods and devices are provided for delivering obesity therapy to a patient. In general, the methods and devices allow for onset of a patient eating solid food, e.g., the patient beginning a meal, to trigger delivery of an obesity therapy to a patient. The obesity therapy can be delivered to the patient for a limited period of time such that the patient stops receiving the obesity therapy prior to a second onset of the patient eating solid food, e.g., the patient beginning a second meal, which can trigger a second delivery of the obesity therapy to the patient for a limited period of time.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: April 15, 2014
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Tamara C. Baynham, Jason L. Harris
  • Patent number: 8674170
    Abstract: An absorbent article, preferably a disposable absorbent article such as a diaper, is disclosed having an absorbent core which imparts increased wearing comfort to the article and makes it thin and dry. The absorbent core useful for an absorbent article comprises a substrate layer, a discontinuous layer of absorbent material, and a layer of thermoplastic material. A second surface of the discontinuous layer of absorbent material is in at least partial contact with a first surface of the substrate layer. Portions of a second surface of the layer of thermoplastic material are in direct contact with the first surface of the substrate layer and portions of said second surface of the layer of thermoplastic material are in direct contact with a first surface of the discontinuous layer of absorbent material. A process for providing a storage layer for an absorbent core useful in an absorbent article is further disclosed.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: March 18, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Ludwig Busam, Uwe Jurgen Becker, Michael Divo, Bruno Johannes Ehrnsperger, Roland Engel, Torsten Lindner, Siegfried Link, Volker Maier, Sanaul Kabir Siddiquee, Gabriele Stiehl, Thomas Tombuelt
  • Publication number: 20140018729
    Abstract: A biomedical haemostatic powder dispenser (1) by which individual doses of powdered medication that are stored in respective chambers of a rotatable carousel (22) are fluidized for delivery to a targeted treatment site (e.g., a wound in order to stop bleeding). In particular, a squeeze handle (7) is activated (i.e., depressed) so as to cause a blast of gas under pressure to be applied from a gas reservoir (30) to a particular one of the powder-filled chambers of the medication carousel so that a single measured does of medication is entrained and delivered to the patient. At the same time that the squeeze handle is activated, the medication carousel is rotated so that a different powder-filled chamber is moved within a fluid path between the gas reservoir and an outlet nozzle tube (10) of the dispenser and a kit for dispensing a powder.
    Type: Application
    Filed: April 26, 2012
    Publication date: January 16, 2014
    Applicant: BIOM'UP
    Inventors: Clark Foster, David Mishelevich, Eric Warner, Aaron Gifford
  • Patent number: 8623046
    Abstract: A device and method for using the device is used for clotting volumes created postoperatively. The device is inserted into a cavity formed by removal of tissue or organ within a patient. The device may have a flexible tubing having a surface material; a blood clotting material enclosed within the surface material of the tubing; a guidewire associated with the device that when placed under tension, stabilizes the tubing radially or longitudinally; and the surface material of the tubing being removable from the enclosed blood clotting material while the guidewire is under tension.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: January 7, 2014
    Inventor: Donald Lee Sturtevant
  • Publication number: 20130310805
    Abstract: A device for delivery of a substance to an external auditory canal and/or nasal cavity can include a reservoir, an aerosolizing mechanism, a nozzle, and a retaining member. The reservoir can contain the substance. The aerosolizing mechanism can suspend a dose of the substance, as particulates for example, in a gas. The nozzle can include a lumen, an outer surface, and a distal end. The lumen can be sized to permit movement of the gas and particulates therethrough. The retaining member can be configured to be attached to the nozzle proximate the distal end of the nozzle, projecting laterally from the lumen of the nozzle, shaped to engage the ear and/or nostril, and can include a passage therethrough to allow passage of gas and to inhibit passage of at least some of the particulates.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 21, 2013
    Applicant: OTITOPIC INC.
    Inventor: Kambiz YADIDI
  • Patent number: 8585659
    Abstract: Devices for delivery of medical compositions in either liquid or powder form include a piercing device for piercing a flexible sheet material in which when contained in a flexible blister dosage form, the piercing device serves as a delivery channel for compositions contained in the blister. The device is configured to reduce or inhibit puncture flap interference with the delivered spray or mist by forming a substantial non-contact drape in the material prior to puncture.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: November 19, 2013
    Assignee: Mystic Pharmaceuticals, Inc.
    Inventor: Christopher D. Shay
  • Publication number: 20130218072
    Abstract: The invention is configured so that pressurized gas from a pressurized gas supply source passes through a pressurized gas channel provided in a main body of a powder spraying device and is sprayed out. A powder container containing powder such as medical agents is provided on the main body. The powder within the powder container is supplied to the pressurized gas channel and is sprayed together with the pressurized gas. An eccentric rotor with a center of gravity deviated from a center of rotation is provided in the main body. When spraying the powder together with the pressurized gas, vibrations are applied to the main body and the powder container by a rotation of the eccentric rotor. The powder can be thereby mixed more evenly with the pressurized gas.
    Type: Application
    Filed: January 12, 2012
    Publication date: August 22, 2013
    Applicant: NIPRO CORPORATION
    Inventor: Tomohiko Kubo
  • Patent number: 8486002
    Abstract: Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: July 16, 2013
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters
  • Patent number: 8464712
    Abstract: A medication inhaler comprising an inhaler body, having a medication container chamber for receiving a medication container and an air passage coupling the medication container chamber with exterior air, and a mouthpiece axially engageable with the inhaler body. The mouthpiece has a mouthpiece chamber and a medication delivery needle communicating with the mouthpiece chamber. The needle extends toward the medication container chamber and has an opening for supplying exterior air and medication from an interior cavity of the medication container, accommodated within the medication container chamber, through the needle and to mouthpiece chamber.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: June 18, 2013
    Assignee: Dose One, LLC
    Inventors: Charles F. Ganem, Jake Ganem, Scott Ganem
  • Publication number: 20130110080
    Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. The systems generally comprise a container having first and second regions and a reservoir containing the therapeutic agent. A pressure source having pressurized fluid is in selective fluid communication with at least a portion of the reservoir. An outlet tube is in fluid communication with the reservoir of the container. At least one slot is formed in a lateral surface of the outlet tube at a position between first and second ends of the outlet tube.
    Type: Application
    Filed: December 21, 2012
    Publication date: May 2, 2013
    Applicant: COOK MEDICAL TECHNOLOGIES LLC
    Inventor: Cook Medical Technologies LLC
  • Patent number: 8430839
    Abstract: Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a first collimator fluidly connected with the gas source adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator has an inlet end and an outlet end. The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 30, 2013
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott Uhland, Eric Peeters
  • Publication number: 20130096493
    Abstract: An administration device can discharge a prescribed, equal amount of medicine a number of times by spraying. A spraying device includes a barrel; a gasket provided slidably movable in liquid-tight manner in the barrel; a rod coupled to a base end of the gasket; and a regulating member provided on the barrel, having a projection that can slidably fit with the guide groove. The guide groove includes at least first and second continuous administering grooves. The second administering groove is configured to include a transitional portion extending in the circumferential direction with a groove wall on the base end side aligned with the base end of the first administering portion, and a second administering portion extending from the transitional portion to a base end along the longitudinal direction. An energizing protrusion engageable with the projection is provided at a boundary between the transitional portion and the second administering portion.
    Type: Application
    Filed: June 28, 2011
    Publication date: April 18, 2013
    Applicant: NIPRO CORPORATION
    Inventors: Tomohiko Kubo, Teruhisa Hirobe
  • Patent number: 8419722
    Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: April 16, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Mark Richards, Brian D. Burkinshaw, Kevin Pauza, James B. Rogan, John Wheeler
  • Patent number: 8409611
    Abstract: A process which can be used in the laboratory or on an industrial scale for cleaning the inner wall of hard gelatine capsules, in which the sealed capsules are cleaned with a powder formulation.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: April 2, 2013
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Herbert Wachtel, Petra Schmidt-Joerg, Volker Freudenberger
  • Patent number: 8403923
    Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 26, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Steven I. Whitlock, Brian D. Burkinshaw, Kevin Pauza
  • Publication number: 20130066262
    Abstract: According to some embodiments, an apparatus may deliver a medication that comprises a multi-dose syringe, a multi-dose medication storage unit coupled to the multi-dose syringe, and a trigger mechanism. The multi-dose medication storage is to comprise a plurality of pre-loaded doses of a medication where the medication is in powder form. Moreover, the trigger mechanism is to facilitate delivery of one or more of the plurality of doses of the medication from the multi-dose medication storage unit.
    Type: Application
    Filed: November 8, 2012
    Publication date: March 14, 2013
    Applicant: POLYBIOTICS LLC
    Inventor: PolyBiotics LLC
  • Patent number: 8388569
    Abstract: Delivery devices, methods and systems are provided for the delivery of particles into a biological tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and adapted to form a collimated stream of the first plurality of particles entrained in the gas. The device also includes a tissue-interfacing surface adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the collimated stream of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: March 5, 2013
    Assignee: Xerox Corporation
    Inventors: Scott Uhland, Eric Peeters
  • Publication number: 20130046278
    Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
    Type: Application
    Filed: October 23, 2012
    Publication date: February 21, 2013
    Inventor: Xin Ji
  • Patent number: 8360057
    Abstract: A medication inhaler for concurrently delivering multiple doses of medications including an inhaler body having a medication container chamber for receiving a plurality of medication containers and at least one air passage connecting the medication container chamber with external air, a mouthpiece axially engageable with the inhaler body and having a mouthpiece chamber for communication with a patient's respiratory system, and a hollow medication delivery needle communicating with the mouthpiece chamber. A medication delivery needle penetrates the medication containers when the inhaler is actuated and has at least one opening for passing exterior air and medication from interior spaces of the medication containers and through the needle to mouthpiece.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: January 29, 2013
    Assignee: Dose One, LLC
    Inventors: Charles F. Ganem, Jake Ganem, Scott Ganem
  • Patent number: 8361052
    Abstract: Methods and systems for treating pleural disease comprising a providing a low dosage of a sclerosing agent over a period of time. Certain examples include catheter with a sclerosing agent that is inserted into the pleural space. The sclerosing agent is released in a sustained-release manner over a period of time to achieve diffuse pleurodesis of the pleural layers.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 29, 2013
    Assignee: UTI Limited Partnership
    Inventor: Alain Tremblay
  • Patent number: 8357147
    Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: January 22, 2013
    Assignee: Spinal Restoration, Inc.
    Inventors: Brian D. Burkinshaw, John L. Wheeler, James B. Rogan, Steven I. Whitlock
  • Patent number: RE45404
    Abstract: Improvement for the device to deliver the powdery medicine into nasal cavities in which a capsule setting/detaching part 40 is built drawably in the capsule housing/holding part 30, and cutting blades 60A, 60B are built in both axial ends of the capsule setting/detaching part 40 of the capsule housing/holding part 30 for cutting both axial ends of the capsule thereby perforating the capsule. A medicine capturing/collecting part 32 and a one-way valve 33 are built in a lower portion of the capsule housing/holding part 30, and a pump 50 having an air inlet valve 54 is built in the air flow inlet side thereof. A medicine delivery part 20 is built in the air exit of the capsule housing/holding part 30, a nozzle 22 is installed and medicine in the capsule can be dosed to the nasal cavities of the user by pressing the pump 50.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: March 3, 2015
    Assignee: Shin Nippon biomedical Laboratories, Ltd.
    Inventor: Tatsuo Tsutsui