Abstract: Methods and systems for treating pleural disease comprising a providing a low dosage of a sclerosing agent over a period of time. Certain examples include catheter with a sclerosing agent that is inserted into the pleural space. The sclerosing agent is released in a sustained-release manner over a period of time to achieve diffuse pleurodesis of the pleural layers.

Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.

Abstract: According to some embodiments, an apparatus may deliver a medication that comprises a multi-dose syringe, a multi-dose medication storage unit coupled to the multi-dose syringe, and a trigger mechanism. The multi-dose medication storage is to comprise a plurality of pre-loaded doses of a medication where the medication is in powder form. Moreover, the trigger mechanism is to facilitate delivery of one or more of the plurality of doses of the medication from the multi-dose medication storage unit.

Abstract: Embodiments of the present technology include a micromachined implantable drug delivery devices, grippers, and syringes that are wirelessly powered and controlled by frequency tuning of external radiofrequency (RF) magnetic fields. An illustrative device can be designed and constructed with passive circuitry and microvalves that operate without batteries, e.g., through thermal actuation of hydrogel microvalves and/or shape-memory alloy members. The frequency selectivity in the device control provides not only a path to achieving reliable and safe operation of drug delivery but also potential applications for selective delivery of multiple drugs.

Abstract: An apparatus for connection to a bottle to assist with pill ingestion includes a generally cylindrical hollow base portion manufactured from a first predetermined material and having a first predetermined size for insertion into a mouth of such bottle. A mechanism is disposed at a predetermined location on such base portion for sealingly engaging such base portion to an interior surface of such mouth of such bottle. A generally cylindrical hollow top portion is operably connected to such base portion closely adjacent an upper end of such base portion, such top portion is manufactured from a second predetermined material and has a second predetermined size and includes an open top end. A mesh material is fixedly disposed at a predetermined location within one of such base portion and such top portion for supporting at least one pill thereon.

Abstract: A blister pack for an inhaler, the blister pack comprising a blister support (10) with a plurality of blisters (11), each blister (11) being hermetically sealed by a closure layer (20), the blister support (10) being in the form of an elongate strip, the blisters (11) being disposed one after the other along said blister support strip, said blister support (10) including two lateral profiles (15), one on either longitudinal side of said blister support (10), said lateral profiles being formed by alternating depressions (18) and projections (16), each projection including an abutment surface (17) for displacing said blister pack in accurate manner each time said inhaler is actuated, each abutment surface (17) being connected to the adjacent abutment surface (17) via a slide surface (19) formed by each depression.

Abstract: A medical device for topical, intranasal or oral administration of dry powder medical compositions includes a unit dose blister form containing an internal piercing device that provides for agitation, dispersion and dispensation of the powder to a user.

Abstract: An airbrake reservoir lock system for an airbrake system of a vehicle is provided. The vehicle has an electronic control module. The airbrake reservoir lock system comprises a primary air reservoir, and a first airbrake reservoir lock. The primary air reservoir has an input port and an output port. The primary air reservoir stores an amount of pressurized air. The first airbrake reservoir lock is disposed in fluid communication with the output port of the primary air reservoir. The first airbrake reservoir lock has a valve portion and an electrical actuator. The valve portion has an open position and a closed position. The electrical actuator positions the valve portion of the first airbrake reservoir lock between the open position and the closed position based upon an output of the electronic control module.

Abstract: An electronic skin treatment device with an integrated specimen dispenser is disclosed, with which specimen dispense can be concurrently applied to target skin area while ultrasonic vibrations, mechanical massaging motions, galvanic stimulations, or light illuminations are used and as such a customizable, easier and better skin beautification can be achieved.

Abstract: The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. The systems generally comprise a container for holding a therapeutic agent, and a pressure source configured to be placed in selective fluid communication with at least a portion of a reservoir of the container. In one embodiment, fluid from the pressure source is directed through a first region of the container in a direction towards a second region of the container. The fluid then is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site. In alternative embodiments, the fluid from the pressure source may be directed through the second region of the container in a direction towards the first region of the container.

Abstract: An inhaler has an air inlet port and an entry passage extending from the air inlet port to a contact chamber inlet port, a contact chamber and an inhaler air outlet port. The contact chamber has first and second opposed ends, a sidewall extending between the first and second opposed ends that in cross section is curved, the second opposed end having an opening in air flow communication with a dosage chamber and a contact chamber outlet port. The contact chamber inlet port is provided in the sidewall and faces a portion of the sidewall opposed to contact chamber inlet port. The contact chamber has a cross sectional area that is greater than the cross sectional area of the entry passage.

Abstract: The invention includes a device for inserting a medicament within a body cavity of a mammal, and a cartridge for containing the medicament within the device, where the cartridge includes a housing, a retractable chamber for containing medicament disposed within the housing, and a substantially stationary member disposed within the barrel of the retractable chamber, where upon activation of the device, the retractable chamber is retracted about the substantially stationary member, thereby depositing medicament within the body cavity.

Abstract: The invention relates to dry free-flowing filler (1) for forming a support structure in a bone cavity (4a). Said filler comprises a plurality of biocompatible support bodies (2) which are resistant to deformation or fracture under the physiologicalloads usually occurring in the bone cavity (4a). Said support bodies (2) have a size between 2 mm and 10 mm and an axis (A) and two opposite abutments (2g) spaced apart in the direction of the axis (A).

Abstract: Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Abstract: A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: A device for the topical dispensing of a powder, typically a powder medicament, comprises, or is adapted to be coupled to, a powder receptacle and a gasflow generator. The gasflow generator is adapted, in use, to cause gas to flow through the device, which further comprises an agitator by which the powder and/or the powder receptacle can be mechanically agitated. Actuation of the gasflow generator, which causes gas to flow through the device and to entrain powder from the powder receptacle, thereby to dispense powder from the device, is accompanied by actuation of the agitator, causing the powder receptacle to be mechanically agitated, thereby facilitating the release of powder from the powder receptacle.

Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.

Abstract: The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.

Abstract: An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.

Abstract: The present invention relates to applicators for applying powders to the vaginal mucosa.

Abstract: Formulations and methods of manufacture are provided for granisetron dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations. Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices.

Abstract: A medication inhaler having an inhaler body with a medication container chamber for receiving a medication container and at least one air passage connecting the medication container chamber with external air and a mouthpiece axially engageable with the inhaler body and having a mouthpiece chamber for communication with a patient's respiratory system and a hollow medication delivery needle communicating with the mouthpiece chamber. The medication delivery needle extends toward the medication container chamber and has at least one opening for passing exterior air and medication from an interior space of a medication container in the medication container chamber through the needle and to mouthpiece chamber.

Abstract: According to some embodiments, an apparatus may deliver a medication that comprises a multi-dose syringe, a multi-dose medication storage unit coupled to the multi-dose syringe, and a trigger mechanism. The multi-dose medication storage is to comprise a plurality of pre-loaded doses of a medication where the medication is in powder form. Moreover, the trigger mechanism is to facilitate delivery of one or more of the plurality of doses of the medication from the multi-dose medication storage unit.

Abstract: A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inhaler device, and into the patient's respiratory system. The system is adapted for ease of use without requiring the user to perform any cumbersome manipulations of the drug packet during insertion into the inhaler or during inhalation of the drug.

Abstract: A system is provided for efficiently gelating and injecting a constant amount of biopolymer powder for effectively using biopolymer in sealing, stanching, and prevention of adhesion of a post-surgical site. Powder transfer line 320 for transferring biopolymer powder atomized with the pressure of noninflammable gas in powder agitating container 220, and transfer lines 310, 330 for separately transferring noninflammable gas and solution separately from the powder transfer line 320, are joined at the tip of nozzle attachment 400 for injecting a mixture of the biopolymer powder and the noninflammable gas, together with the noninflammable gas and the solution.

Abstract: A device that delivers a powdery medicine for a nasal cavity includes positioning guides that cause a capsule to slide as far as a predetermined position and are provided on the side of cutters to make holes on both ends of the capsule provided between the connection port on the side of a nozzle that sprays the powdery medicine into the nasal cavity. The device further includes a connection port on the side of a pump that supplies spray air to the nozzle in order to make the size of the holes made on both ends of the capsule constant, wherein a distance between the connection ports is made shorter than a distance between blade tips of the cutters.

Abstract: Dry powders containing bioresorbable hyaluraonic acid (“HA”) are applied directly to a desired location in a patient wound to reduce adhesions, without first forming a hydrated gel. HA includes hyaluronic acid that has been modified, cross-linked or combined with other substances. it is important to control the size of the particles in the powder. The powder is essentially dry and blowable powder. At least 90% of powder particles have a maximum dimension between 30 ?m and 1 mm.

Abstract: A nasal delivery device for and method of delivering substance to the middle meatus in a nasal cavity of a subject in the treatment of a condition, in particular an inflammatory or infectious condition, thereof, the delivery device comprising: a nosepiece unit (17) including a nosepiece (20) for fitting to a nostril of a subject and a nozzle (25) through which substance is in use delivered to the respective nasal cavity; and a delivery unit (29) for delivering substance through the nozzle of the nosepiece; wherein the delivery device is configured to provide for deposition of a significant fraction of the delivered dose on, around and in the vicinity of the middle meatus.

Abstract: A delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: at least one nosepiece unit (21) for insertion into one nasal cavity of a subject and comprising a nosepiece (25) for fitting to the respective nostril of the subject; and at least one delivery unit (23) which is operative to deliver a substance through the at least one nosepiece unit into the one nasal cavity of the subject, wherein the at least one delivery unit includes a substance supply unit (27) for delivering a substance and an actuation unit (29) which is operable to actuate the substance supply unit, either automatically or manually, in response to nasal exhalation or at least attempted nasal exhalation by the subject.

Abstract: Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.

Abstract: A sustained release nasal formulation for delivery to a nasal cavity of a subject, wherein the formulation provides for sustained release of a substance, in particular nitric oxide (NO), to nasal mucosa within the nasal cavity so as to provide one or both of a therapeutic effect and promote normal nasal function, and a nasal delivery device and method relating thereto.

Abstract: The present embodiments provide apparatus and methods suitable for delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through container towards the target site. In an alternative embodiment, the container and the pressure source may be coupled to first and second inlet ports of a connecting member, respectively, such that the therapeutic agent flows through an outlet port of the connecting member and towards the target site.

Abstract: A system is provided for efficiently gelating and injecting a constant amount of biopolymer powder for effectively using biopolymer in sealing, stanching, and prevention of adhesion of a post-surgical site. Powder transfer line 320 for transferring biopolymer powder atomized with the pressure of noninflammable gas in powder agitating container 220, and transfer lines 310, 330 for separately transferring noninflammable gas and solution separately from the powder transfer line 320, are joined at the tip of nozzle attachment 400 for injecting a mixture of the biopolymer powder and the noninflammable gas, together with the noninflammable gas and the solution.

Abstract: Parts of a powdered medicine multi-dose administering device are assembled, powdered medicine is filled and assembly that is obtained is inspected all on an automatic production line to increase productivity while preventing the production of defective products. The powdered medicine multi-dose administering device is produced through automated steps of inserting a filter (12) in a filter-fitting portion (11a) of a container (10), inserting an inner cylinder (15) in the container body (10), filling the container with the powdered medicine through a ring-like opening between an opening in the upper part of the container and the inner cylinder, fitting an inner closure (19) to the container and to the inner cylinder, fitting a nozzle (20) to the container while coupling it to the inner cylinder, and inspecting the thus obtained assembly.

Abstract: A hand-held dispenser for dispensing a pharmaceutical product is disclosed. The dispenser has a housing providing a duct. A frangible membrane is provided in the duct. A probe with a piercing tip is mounted in the duct and arranged such that, in use the piercing tip pierces the frangible membrane. An air compression device is provided to compress air for expelling a pharmaceutical product through the probe and a channel is provided to substantially equalise the pressure in the air compression device and the pressure above the frangible membrane. The ability to substantially equalise the pressure in the bellows and the pressure above the frangible membrane on the sheath provides for a mote consistent release of pharmaceutical product when the frangible membrane is pierced.

Abstract: The invention relates to an apparatus for dispensing a restricted amount of powdered material, comprising a repository (2) for powdered material (4), an outlet (12), and a conduit (3). The apparatus defines an airway arranged to enable air to be drawn through the resting powdered material in the repository, thereby entraining the powdered material in the airflow and drawing the air and entrained powdered material through the conduit. The air and entrained powdered material is thereafter expelled out of the outlet. Additionally, the invention relates to a dip tube (3) for use in apparatus for dispensing a powdered material.

Abstract: The invention provides a device which seeks to ensure that substantially all the particles delivered avoid interaction with the so-called “starting process”. There is provided a needleless injection device comprising a driver chamber (51) arranged, in use, to contain a charge of pressurised gas, a duct section (52) connected to the driver chamber (51) to receive gas therefrom and a closure means (53) for preventing the flow of gas from the driver chamber (51) to the duct section (52) until the closure means (53) is opened. Further, a dose of particles (58) is positioned within the device in the region of the closure means (53).

Abstract: A medicine administering device for nasal cavities of a patient suffering from nasal allergy or the like. The medicine administering device comprises a medicine administering device main body including a part defining a powdery medicine accommodating chamber, and a spray nozzle located at a tip end side of the main body. A pump is disposed at a base end side of the medicine administering device main body to discharge air within the pump through the powdery medicine accommodating chamber to the spray nozzle upon being pressed from an outside of the pump. Additionally, a restricting device is disposed within the pump to restrict a displacement amount of the pump in accordance with first and second kinds of pressing positions at which the pump is pressed. The first and second kinds of pressing positions lie respectively in first and second directions which are perpendicular to each other.

Abstract: A system is provided for efficiently gelating and injecting a constant amount of biopolymer powder for effectively using biopolymer in sealing, stanching, and prevention of adhesion of a post-surgical site. Powder transfer line 320 for transferring biopolymer powder atomized with the pressure of noninflammable gas in powder agitating container 220, and transfer lines 310, 330 for separately transferring noninflammable gas and solution separately from the powder transfer line 320, are joined at the tip of nozzle attachment 400 for injecting a mixture of the biopolymer powder and the noninflammable gas, together with the noninflammable gas and the solution.

Abstract: An exhalation breath-actuated nasal deliver device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a mouthpiece through which the subject in use exhales; and delivery unit, as one of a mechanical delivery pump or a nebulizer, for delivering a substance to the nosepiece; and an actuation mechanism for actuating the delivery unit in response to oral exhalation through the mouthpiece, and preferably when at least one or both of the pressure at or the flow rate through the nosepiece exceeds a predetermined threshold.

Abstract: An apparatus and method for reducing post-operative ileus and/or gastric stasis is described. The method can include applying to the intestine a therapeutically effective amount of a composition comprising a drug that is effective in reducing post-operative ileus and/or gastric stasis, such as by introducing the composition through a surgical access device, such as a trocar or endoscope. The apparatus can include a surgical fastener and a buttress comprising the composition.

Abstract: An atomization device comprises a conduit containing liquid to be atomized, a spray electrode (1) and a discharge electrode (3). Each electrode is adjacent to a dielectric (5) and they are connected in an electrical circuit (10) to enable a potential difference to be applied between them to atomize the liquid and to generate charge carriers of a first polarity in the proximity of the spray electrode (1) and ions of a second polarity in the proximity of the discharge electrode (3). Some of the first polarity charge carriers deposit on the dielectric adjacent to the spray electrode (1) and some of the second polarity ions deposit on the dielectric (5) adjacent to the discharge electrode (3) so that the atomized liquid is repelled from the dielectric (5) adjacent to the spray electrode (1) and electrically discharged by second polarity ions that are repelled by the dielectric (5) adjacent to the discharge electrode (3).

Abstract: A dry powder inhaler, including a housing having an airflow path leading from an inlet, past a powder release location, to a mouthpiece; a drive spool engaged with a capstan adjacent to the powder release location; a spring biasing a ratchet into engagement with the drive spool; and a breath trigger in the airflow path. The breath trigger is moveable from a first position, wherein the breath trigger holds the ratchet, to a second position, wherein the breath trigger releases the ratchet to allow the ratchet to turn the drive spool.

Abstract: A method for operating a dry powder inhaler, the dry powder inhaler having a dose tape having spaced apart doses of a powder pharmaceutical, each dose being in a respective sealed blister. The inhaler includes a breath actuated blister opening system that sequentially opens a blister on the tape. The method involves routing the dose tape between first and second rotating elements; spring biasing the first rotating element to turn in a first direction; holding the first rotating element from rotating against the spring biasing; and releasing the first rotating element, and allowing it to rotate a fraction of one rotation, when air flows adjacent to the first rotating element.

Abstract: A medicament container (10) is disclosed which comprises at least two compartments (21, 22). Each of the compartments (21, 22) is adapted to contain a dose of a medicament in powdered form and is provided with at least one opening (23) through which, in use, the medicament can be dispensed. The container (10) is preferably cylindrical in form, the diameter of the cylinder being greater than its depth such that the container (10) has the form of a squat drum.

Abstract: Improvement for the device to deliver the powdery medicine into nasal cavities in which a capsule setting/detaching part 40 is built drawably in the capsule housing/holding part 30, and cutting blades 60A, 60B are built in both axial ends of the capsule setting/detaching part 40 of the capsule housing/holding part 30 for cutting both axial ends of the capsule thereby perforating the capsule. A medicine capturing/collecting part 32 and a one-way valve 33 are built in a lower portion of the capsule housing/holding part 30, and a pump 50 having an air inlet valve 54 is built in the air flow inlet side thereof. A medicine delivery part 20 is built in the air exit of the capsule housing/holding part 30, a nozzle 22 is installed and medicine in the capsule can be dosed to the nasal cavities of the user by pressing the pump 50.

Abstract: Disclosed is a system for delivery of a drug comprising a multiple unit dosing device comprising a housing and an actuator, said device containing multiple doses of multiparticulates comprising drug particles, said device upon actuation delivering a unit dose of said multiparticulates, said drug particles having a mean diameter of greater than 10 ?m to about 1 mm such that an effective dose of said drug cannot be delivered into the lower lung of a human patient. Also disclosed are novel methods, devices and dosage forms for delivering a drug.

Abstract: A dry powder inhaler includes an actuator pivotably mounted on a base. Movement of the actuator from a first position to a second position drives the a dobber to open a blister. A dispersion engine sub-assembly has a blister hood positioned over a blister opening position. A powder pathway connects from the blister hood into a powder dispersion engine. Upon inhalation, air flow draws powder up and out of an opened blister, into the blister hood and to the powder dispersion engine. Movement of the actuator causes the dobber to shear open a blister and also to press the blister hood down over the blister. This increases air flows up and around the open blister, carrying the pharmaceutical powder up and out of the blister and into the dispersion engine.

Abstract: A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.

Abstract: A dispenser has a body 201 with a mouthpiece 202 and a pivoted mouthpiece cover 203. The mouthpiece is formed as an aperture 2021 in a separate body part 2012 clipped to a main body part 2011. The mouthpiece part is cut away 2014 with respect to the medicament can 211 fitted to the body to define an air inlet exposed by the cover when this is open. The cover is pivoted about an axis 204 low in the body at the joint between the two body parts. Integrally moulded with the cover 203 is a half round shaft 2031, which carries a cam arrangement 205 comprising a pair of cam lobes 2051, 2052 and an intermediate shaft 2053. The can 211 is held in an opening 210 at the upper end of the main body part 2011 by a pair of location pins 2101 in openings 2102 in sidewalls of the body part. A junction member 217 is slidably accommodated in the body with the ribs engaging in grooves 218 in its periphery.