Abstract: A drug delivery device for delivery of medicament having a delivery pump system and a cartridge system, the delivery pump system operating electromagnetically by driving two disk magnets that are housed within pump body inserts of the cartridge system. The displacement of the magnets and an elastomer membrane placed between the magnets of the cartridge system results in a volumetric change within two reservoirs and the flow of medicaments. The medicament flows from the reservoirs to the inlet/outlet members via the pump body inserts and discharged to a patient user's body through an infusion set.

Abstract: A handheld diabetes managing device that provides a secure and efficient communication link between an insulin pump and an external computing device. The handheld diabetes managing device can include a blood glucose meter, a processor and first and second communication modules. The handheld diabetes managing device can be configured to deliver data between an insulin pump and an external computing device over a secure communication path without a direct communication link between the insulin pump and the external computing device. The secure communication path can include a first secure bidirectional communication link between the handheld diabetes managing device and the insulin pump and a second secure bidirectional communication link between the handheld diabetes managing device and the external computing device.

Abstract: Some embodiments of an infusion pump system can include a controller in which one or more features sets to be provided by the controller are enabled or disabled based upon the particular pump device that is connected to the controller. For example, in some embodiments, one or more advanced features of the controller are available to the user only when a first type of pump device (e.g., having predefined settings stored therein) is connected to the controller, and those advanced features of the controller are disabled when a second type of pump device is connected to the controller.

Abstract: The present invention relates to a medical device for analyzing cardiac related input signals. The device is capable of receiving an ECG-signal and a nerve activity signal, such as vagus nerve signal in order to detect a cardiac related neural activity, such as epilepsy. The device is programmed for detecting a trigger feature (e.g. the R-peak) in the signal and extracting a nerve activity signal segment from the nerve activity signal in response to detecting the trigger feature. An activity related feature is generated either based on a combined signal obtained from a number of nerve activity signal segments, or as a segment-based activity related feature obtained from a number of nerve activity signal segments. Moreover, the device is adapted for comparing the activity related feature to a predefine criterion in order to detect the cardiac related neural activity.

Abstract: Described and illustrated herein are an exemplary methods and system to display analyte sensor data. Such method may be achieved by the medical device receiving data from the analyte sensor for a period of time and displaying a target zone and a graphical representation of the data in which one or more portions of the graphical representation comprises a specific indicia of clinical risk.

Abstract: The invention is directed to a medical equipment system by means of which the provision of medication to a patient is adapted according to continuously recorded physiological measurement signals. The object of the invention is to find ways by which medication can be administered to a patient with a high degree of accuracy. This object is achieved, according to the invention, by a medical equipment system with a spectrometer for recording measurement signals from vital tissue of a patient, in particular for continuously determining the material composition of body liquids and also of tissue-bound substances possibly present only temporarily in the corresponding tissue area, with a signal processor for processing the measurement signals supplied from the spectrometer and for generating a medication signal, and with medication equipment for administering a medicament according to the medication signal.

Abstract: A medical device for carrying out at least one medical function, comprising at least one element that can be at least partially inserted into a body tissue of a user and further comprising at least one housing that can be placed on a skin surface of the user. The housing has a multipart design and comprises at least one functional component. The functional component can be connected to the insertable element. The housing further comprises at least one protective component. The protective component is designed to at least partially enclose the functional component. The protective component can be connected to the functional component, particularly after insertion of the insertable element.

Abstract: A diabetes care kit for providing diagnostics and therapy that is preconfigured to reduce initial setup by a user. The kit can include a handheld diabetes managing device and insulin pump. The handheld diabetes managing device and insulin pump can each be preloaded with an encryption key such that the handheld diabetes managing device and the insulin pump are paired and a secure bidirectional communication link exists between the handheld diabetes managing device and the insulin pump.

Abstract: The invention relates to an ophthalmic system for controlling an infusion liquid pressure at a distal end of an ophthalmic irrigation device penetrating an eye and being connected to an irrigation line for feeding the device with an infusion liquid. The system comprises a processor that is arranged for estimating a compensation pressure for compensating an internal pressure loss in the eye due to surgical acts in the eye. The estimation result is used for dynamically adjusting, in response to the estimated compensation pressure, the pressure of the irrigation liquid in the irrigation line. The estimation step is based on a configuration and/or actual operation of an ophthalmic surgical device performing the surgical acts in the eye.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes an enclosure including one or more sensors, a controller, and one or more applicators configured to surround one or more joints of articulating bone of a mammalian subject, wherein the one or more sensors are configured to detect one or more physiological conditions of the one or more joints of the mammalian subject, and the controller, configured to communicate with the one or more sensors, is configured to activate the one or more applicators, and wherein the one or more applicators are configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes an enclosure including one or more sensors, a controller, and one or more applicators configured to surround one or more joints of articulating bone of a mammalian subject, wherein the one or more sensors are configured to detect one or more physiological conditions of the one or more joints of the mammalian subject, and the controller, configured to communicate with the one or more sensors, is configured to activate the one or more applicators, and wherein the one or more applicators are configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.

Abstract: A dermal or transdermal drug-delivery skin patch has a blood pressure sensor structurally integrated or built into it. The skin patch when attached to a skin portion of an individual determines a blood pressure of the individual and in response needle-lessly delivers a treatment drug to the individual if necessary.

Abstract: An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.

Abstract: An inflatable cuff in a blood pressure-measurement system is integrated with a drug delivery device. The drug delivery device is configured to automatically deliver a drug dermally or transdermally to the individual in response to the measured blood pressures.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Abstract: An in vivo device (1) for an at least temporary placement in a human or animal body (17), comprising an actuator (2) adapted to be actively triggered from the exterior in order to induce a local impact on the adjacent body area for in vivo treatment of a patient in need, and/or comprising a sensor adapted to be actively triggered from the exterior for sensing a pathological condition in the body (17). An in vivo system comprises at least two and/or a plurality of the in vivo devices (1), wherein the in vivo devices (1) are adapted to communicate with each other and/or with an external controller (24). The use of the in vivo device/s (1) for treating and/or diagnosing a pathological condition in a human or animal body (17) comprises: administering the device/s (1); monitoring the movement of the device/s (1) through the body (17); triggering the device/s (1) from the outside once the device/s (1) reach/es a defined position in the body (17).

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: A system and method for monitoring at least one blood parameter of the blood of different patients, comprising a plurality of access devices for establishing at least one means of access to the blood of each patient through the skin, a plurality of removal devices for removing a quantity of blood from each patient in order to obtain at least one blood sample, at least one blood analysis device for analysing the blood sample with respect to predeterminable blood parameters and for generating individual blood parameter data sets, a calculation device which can be used jointly for a plurality of blood parameter data sets of different patients for calculating data sets of drug parameters of the drugs to be administered to the respective patient on the basis of the individual blood parameter data sets, and a plurality of supply devices for supplying the respective drug having the calculated drug parameters.

Abstract: Techniques for controlling therapy based on a physiological parameter indicative of ventricular filling pressure, such as various cardiovascular pressures, are described. One or more values of the physiological parameter that are collected during nighttime, or while the patient is otherwise asleep, inactive, or within a recumbent position, may be compared to one or more values of the physiological parameter collected during daytime, or while the patient is otherwise awake, active and/or upright. A therapy, such as for treating physiological factors that may lead to worsening HF, may be initiated or adjusted based on the comparison, e.g., if the nighttime values exceed the daytime values.

Abstract: An apparatus and a system for controlling and/or managing administration of a drug to a body of a patient. The apparatus includes a drug infusion device configured to deliver drug at a predetermined location in the body of the patient, at least one sensor disposed in the drug infusion device and configured to measure a. corresponding property related to the patient and selected from the group consisting of physiological properties, biochemical properties, environmental properties and drug-related properties, a controller disposed in the drug infusion device and configured to receive from the at least one sensor data representative of the measured corresponding property and based on the received data, determine a drug delivery rate. The drug delivery device is configured to deliver the drug to the body of the patient based on the determined drug delivery rate.

Abstract: A method for draining autologeous biological fluid includes positioning a catheter to receive the autologeous biological fluid from a selected site in a mammalian body with the end of the catheter adapted to receive such fluid. An output end of the catheter is positioned into the intraosseus space. The fluid is transmitted through the catheter to intraosseus space thereby draining the selected site from the autologous biological fluid.

Abstract: Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.

Abstract: An insulin pump comprises a pump device, a control for the pump device, a memory, an operating element for operating the insulin pump and a method for controlling a user interface of the insulin pump are disclosed. The control is designed and programmed such that options for the user of the insulin pump are displayed by the user interface as a function of a user-specific preference profile stored in the memory and as a function of a current time and are provided for selection by using the operating element. The insulin pump can be designed in an auto-adaptive fashion, such that the control continuously updates the user-specific preference profile based on analyzing operating inputs of the user. Embodiments of the invention allow a large range of functions and simple operation, even in the case of miniaturized pumps.

Abstract: An ACS therapy system for continuously monitoring Intra-Abdominal Pressure (IAP) and preventing the onset of ACS. The automated ACS therapy system includes a urine withdrawal device, an IAP regulation circuit, an IAP monitor connected to the urine withdrawal device to supply an IAP value to the IAP regulation circuit, and an abdominal fluid removal device. The abdominal fluid removal device may be connected to an active suction device, which withdraws fluid from the abdominal cavity through the abdominal fluid removal device when activated by the IAP regulation circuit. Based on the IAP value, the IAP regulation circuit may send a control signal that controls the active suction device to turn on and drain fluid from the abdominal cavity. When the IAP value reaches certain levels, the IAP regulation circuit may cause the active suction device to be turned off.

Abstract: A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

Abstract: Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.

Abstract: A diabetes care kit for providing diagnostics and therapy that is preconfigured to reduce initial setup by a user. The kit can include a handheld diabetes managing device and insulin pump. The handheld diabetes managing device and insulin pump can each be preloaded with an encryption key such that the handheld diabetes managing device and the insulin pump are paired and a secure bidirectional communication link exists between the handheld diabetes managing device and the insulin pump.

Abstract: A system and method are provided to associate a medication name with an infusion pump and to communicate that association to a patient data management system (“PDMS”) for display and monitoring. In the case where the infusion pump does not contain a library of selectable medical fluid names that includes the name of the medical fluid to be infused, a separate computer will display a list of medical fluid names for the infusion pump and the operator may select the name of the medical fluid for that infusion pump. The computer will then continually associate that medical fluid name with that infusion pump and communicate the association to the PDMS. In the case where the infusion pump is capable of accepting an upload of new medical fluid names, the computer will upload an abbreviated list of fluid names so as not to overburden the computer with the transfer of large amounts of data.

Abstract: A system implantable components (32, 36, 38, 40) for providing therapy to or monitoring the physiologic state of living tissue. The components exchange signals over implanted bus (34). The bus includes a trunk (84) and at least one branch (14) The at least one branch is connected to and able to move relative to the trunk. Signals are inductively exchanged between the branch and the one or more trunks.

Abstract: In an infusion circuit (1), a peristaltic pump (7) displaced the infusion fluid along a line (3), sourcing it from a batch container (2). When a weight sensor (5) detects an emptying of the batch container (2), the pump is halted. If on stopping the pump the pressure measured by a sensor (6) operating in an expansion chamber (4) does not drop in excess of a predetermined threshold with respect to a non-empty container (2), a non-secure situation is signalled, due to an excessive quantity of air in the expansion chamber.

Abstract: A system for monitoring at least one biological tissue of a patient during a period of at least 24 hours. The system comprises an implantable intrabody probe and an extrabody probe which propagate an electromagnetic (EM) signal, using an antenna, via at least one tissue therebetween, in a plurality of sessions during a period of at least 24 hours, a processing unit which analyses the EM signal to detect a change in at least one biological parameter of the at least one tissue, and an output unit which outputs the change.

Abstract: The invention relates to a secure system for the perfusion of a body liquid, enabling a final control of compatability of a treatment with the patient and/or the medical situation previously diagnosed by a doctor, in a simple, efficient and energy-saving manner.

Abstract: Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like.

Abstract: Devices, systems and methods are disclosed for the formation of an arteriovenous fistula in the limb of the patient. Embodiments include an apparatus for the creation, modification and maintenance of a fistula, including the modification of an existing dialysis fistula; and a method of supplying oxygenated blood to the venous circulation of a patient. A kit of anastomotic implants is described which supports a broad base of patient anatomies and fistula locations. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.

Abstract: A medical system includes a monitoring unit and a drug delivery unit. The monitoring unit is operable to monitor at least one physiological parameter of a patient. The drug delivery unit includes an integral volume of a drug. A control logic is in communication with the monitoring unit and the drug delivery unit and is operable to regulate delivery of the drug to the patient from the integral volume, based on data associated with the at least one physiological parameter of the patient, in accordance with a safety shell control algorithm. A user interface feature is operable to receive input indicating administration of an external drug to the patient. The safety shell control algorithm responds to inputs received through the user interface feature indicating administration of an external drug to the patient, such as by modifying subsequent drug delivery regulation based on the administration of the external drug.

Abstract: A system and method to automatically initiate an injection procedure of a medicament into a patient. In the system, a delivery assembly includes an injector for infusing the medicament into the patient. Further, the system includes a monitor for detecting a parameter characteristic of the procedure, for instance, a pressure indicative of a partial vacuum between the injector and the injection site, a pressure exerted by the patient against the delivery assembly, a conductance, a capacitance, or an optical blood reading. Also, the system includes a timer for determining compliance of the parameter within a predetermined range during a first time interval. In response to the timer, an actuator initiates the injection procedure at the expiration of the first time interval. Further, the actuator may stop the injection procedure if the parameter is outside the predetermined range during a second time interval.

Abstract: A closed loop infusion formulation delivery system for controlling a biological state in the body of a user includes a sensor for generating a signal representative of measured parameters and a computing element for processing the generated signal. The computing element adjusts control parameters within an algorithm, calculates a delivery rate of an infusion formulation and generates commands based on the calculated delivery rate. A remotely located monitoring station communicates with the computing element via radio or wire to further adjust the control parameters within the algorithm to meet changing needs in the body of the user.

Abstract: A docking apparatus comprises a processor, a battery charging module, a storage device, and one or more ports, which are configured to couple with patient monitoring units. Each patient monitoring unit is operable to monitor at least one physiological parameter of a patient. The battery charging module charges the patient monitoring units through the ports. The storage device stores data received from the patient monitoring units through the ports. The processor transmits updates to the patient monitoring units through the ports. The ports may comprise sockets that receive plugs from cables of the patient monitoring units. The docking apparatus may comprise a plurality of separate dock housings associated with corresponding patient monitoring units. These dock housings being joined together in a daisy chain. The docking apparatus may also include a plurality of docking recesses in a single housing, with each docking recess being associated with a corresponding patient monitoring unit.

Abstract: A minimally-invasive surgical procedure for monitoring a physiological parameter within an internal organ of a living body. The procedure entails making a first incision in the body to enable access to the organ. An endoscopic instrument is then inserted through the first incision and a second incision is made therewith through an external wall of the organ and into the internal cavity thereof. A sensing unit is placed in the second incision such that the second incision is occluded by the unit and a proximal end of the unit is outside the organ. The unit includes a sensing device having a sensing element adapted to sense the physiological parameter within the organ, and an anchor to which the sensing device is secured. The first incision is closed, after which a readout device outside the body telemetrically communicates with the sensing device to obtain a reading of the physiological parameter.

Abstract: A medical system includes a monitoring unit and a drug delivery unit. The monitoring unit is operable to monitor at least one physiological parameter of a patient. The drug delivery unit includes an integral volume of a drug. A control logic is in communication with the monitoring unit and is operable to regulate delivery of the drug to the patient from the integral volume, based on data associated with the at least one physiological parameter of the patient, in accordance with a safety shell control algorithm. A user interface feature is operable to receive input indicating a stage of progress in a medical procedure. The safety shell control algorithm responds to inputs received through the user interface feature indicating a stage of progress in a medical procedure, such as by modifying subsequent drug delivery regulation based on the beginning or completion of a stage of progress in a medical procedure.

Abstract: A medical device is disclosed. The medical device includes an RFID reader for receiving information from at least one RFID transponder. The medical device also includes a memory for storing a database and at least one processor for processing information. Also, a remote controller for a medical device is disclosed. The remote controller includes an information receiver for receiving information related to food. The infusion device also includes a memory for storing a database and at least one processor for processing information. A method for use in a medical device is also disclosed. The method includes receiving information from an RFID transponder related to food. Also, the processing the information by comparing the information to a database is included in the method. The method also includes determining the acceptability of the food and providing information related to acceptability to the user.

Abstract: A medical system includes a sedation system and a central station in communication with the sedation system. The sedation system includes a monitoring unit and a drug delivery unit. The monitoring unit is operable to monitor at least one physiological parameter of a patient. The drug delivery unit is operable to deliver drugs to the patient based on data from the monitoring unit. The central station is operable to store patient related data and access a plurality of sedation systems. The central station may remotely control drug delivery through sedation systems, remotely provide voice instructions through sedation systems, display video feeds from sedation systems, respond to queries from sedation systems, and/or provide other functionalities. The system may also include an instrument that is operable to perform surgical and/or therapeutic procedures on the patient. The sedation system may provide power to the instrument and/or otherwise communicate with the instrument.

Abstract: Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting an adverse condition associated with the monitored physiological condition or the medication administration deviating from a predetermined safety level of the closed loop control operation, and initiating a non-zero pre-programmed medication delivery rate are provided.

Abstract: The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.

Abstract: Described herein is an apparatus that includes an endotracheal tube or airway device having a proximal end and a distal end and an occlusion cuff. The occlusion cuff includes a sensor for helping determine proper endotracheal or airway device placement.

Abstract: An ambulatory infusion device for infusion of a liquid drug into a patient's body over an extended period of time and methods thereof are disclosed. The device includes a sensor assembly, which produces a sensor assembly output based on an infusion characteristic of the ambulatory infusion device and based on a supply voltage/current, and a supply unit which is coupled to a sensor of the sensor assembly and generates the supply voltage/current. A sensor testing unit detects a failure of the sensor assembly, wherein the sensor testing unit is coupled to the sensor assembly and the supply unit, and the sensor testing unit carries out a sensor testing sequence. The sensor testing sequence includes controlling the supply unit so as to produce a variation of the supply voltage/current, and determining whether the variation of the supply voltage/current produces a corresponding variation of the sensor assembly output.

Abstract: An infusion system to administer a fluid includes an infusion pump with a pump processor, a pump memory to store a plurality of configurable alarms and a pump radio to enable bi-directional communication. The infusion system further includes a controller that has a controller processor, a controller memory, a controller radio to transmit and receive communication from the pump radio. The controller further has a graphical user interface shown on a display along with controls to manipulate the graphical user interface. Furthermore, the bi-directional communication between the infusion pump and the controller establish an infusion pump relative proximity between the infusion pump and the controller such that when the infusion pump relative proximity exceeds a pump threshold distance at least one of the plurality of configurable alarm conditions of the infusion pump is modified.

Abstract: The invention provides decomposing apparatus which comprises a first sub-component and a first micro device comprising a decomposable material, wherein the sub-component comprises a drug, a medical kit, a micro-disease detection system, or an auto-navigation system. Also within the invention are methods for fabricating such apparatus.

Abstract: The invention relates to a sensor (2) including: a microelectrode assembly (21); and ?-pancreatic cells (23) or islets (230) of Langerhans in culture on the microelectrode assembly (21); characterized in that the microelectrode assembly (21) is designed to measure dynamically, continuously and in real time, electrical signals (V) produced by the ?-pancreatic cells (23) or the islets of Langerhans (230) upon physiological activation. The invention also relates to the field of devices that can be implantable in the body of a patient, and including an insulin dispenser for dispensing an amount of insulin. The invention also relates to a method for manufacturing such a sensor and to such a device and a use of such a sensor.