Abstract: Systems, devices and methods are presented in the subject disclosure for recommending an insulin dose adapted for use with an insulin delivery device. In some embodiments, the method may include receiving blood glucose (BG) data, determining one or more insulin sensitivity (IS) values associated with the BG data, and determining an insulin dose based on the determined one or more IS values. A system for carrying out such a method is also presented.

Abstract: The invention relates to a system and a method for monitoring at least one blood parameter of the blood from a predetermined patient, with an access device for setting up access to the patient's blood, a removal device for removing an amount of blood in order to obtain a blood sample, a blood analysis device for analysing the blood sample, and a calculation device for calculating drug parameters of a drug to be administered to the patient as well as a supply device for supplying the drug having the calculated drug parameters. The system identifies the blood samples using bar codes, as a result of which there are no errors when assigning the blood to be analysed to the respective patient.

Abstract: The patient-controlled analgesia (PCA) safety system includes a housing with a hollow compartment. A display and keypad are disposed on one side of the for display of monitoring data and selective commands respectively. An analgesic module and an antidote module are detachably mounted inside the compartment. A control module is disposed inside the housing. A vital signs monitor is connected to the control module to monitor a patient. In the event of abnormal readings due to, e.g., overdose or drug-related complications, the control module can automatically administer an antidote to the analgesia. The control module can also alert a nurse monitor and/or other personnel wirelessly to insure someone is notified of the potential emergency. The PCA safety system can also be provided in a separate safety module having a detachably mounted antidote module.

Abstract: An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to control the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused as a bolus and to be removed from the basal delivery of the fluid.

Abstract: A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g.

Abstract: An apparatus for delivering a bolus of a medical agent to a patient. The apparatus comprises a pump mechanism, a data input device, and a processor in data communication with the keypad and arranged to control the pump mechanism. The processor is programmed to receive data specifying a bolus amount through the data port, receive data regarding duration through the data port, receive a percentage through the data port, the percentage defining a portion of the bolus amount to deliver immediately upon executing a deliver command and a remainder of the bolus amount to deliver over the duration upon executing a deliver command, and execute the deliver command thereby controlling the pump mechanism to deliver the bolus. Also a method of temporarily adjusting the delivery rate of an infusion pump. The infusion pump is programmed to deliver a basal rate.

Abstract: Devices, systems, or methods are disclosed herein for treatment of disease in a vertebrate subject. The device can include a quasi-planar substrate; and one or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the one or more laterally-mobile effector molecule types is configured to interact with one or more cell types. The device can further include one or more sensors configured to detect at least one aspect of an interaction between the at least one of the one or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the one or more laterally-mobile effector molecule types, the quasi-planar substrate, and the one or more cell types.

Abstract: An integrated insulin delivery system having safety features for controlling medication delivery includes automatic resumption of basal rate after a particular event, such as termination of a bolus, expiration of a time period, delayed resumption after the bolus has terminated, IOB comparison, and others. Other safety features include overriding a delivery control that may result in hypoglycemia, terminating an extended bolus or temporary basal rate in view of a glucose signal indicating imminent carbohydrate deficiency, and controlling the delivery rate to take an asymmetrical bias range of a glucose sensor into account to avoid hypoglycemia.

Abstract: Devices, systems, or methods are disclosed herein for treatment of disease in a vertebrate subject. The device can include a quasi-planar substrate; and one or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the one or more laterally-mobile effector molecule types is configured to interact with one or more cell types. The device can further include one or more sensors configured to detect at least one aspect of an interaction between the at least one of the one or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the one or more laterally-mobile effector molecule types, the quasi-planar substrate, and the one or more cell types.

Abstract: Methods, computer systems, and computer-readable storage media for monitoring and managing patient discomfort are provided. Inputs are received from ambient sensors located in a clinical care room. Based on a determination that the inputs exceed predetermined thresholds, it is determined that the patient is experiencing discomfort. Various measures are automatically initiated to help diminish the patient's discomfort. The measures include aromatherapy, visual relaxation therapy, audio therapy, and automatic administration of pain relief.

Abstract: Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.

Abstract: A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.

Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver a fluid, a wireless communication port, a controller, and a housing to enclose the apparatus. The controller is configured to communicate with a second device via the communication port using an open standard wireless communication protocol. The housing includes a mechanical coupling to slidably engage the second device which includes a second wireless communication port. Slidably engaging the second device positions the first and second communication ports opposite each other to allow communication via the first and second communication ports when slidably engaged.

Abstract: A core apparatus connectable to at least one sensor and to at least one fluid delivery device which includes a base housing, a connection hub to couple to the at least one sensor and to the at least one fluid delivery device, and a controller disposed within the base housing to communicate with the at least one sensor and to the at least one fluid delivery device, wherein the controller forms a continuous feedback loop with the at least one sensor and the at least one fluid delivery device.

Abstract: The inventive endoscopy system includes a cannula for arranging an endoscope and forming, between said cannula and endoscope, an irrigation or aspiration channel for transporting an irrigation or aspiration fluid, respectively, a connection ring mounted around the cannula and provided with a connection channel connectable to the irrigation or aspiration channel, respectively and a connector which is mounted on the connection ring and includes a transport channel with the connection channel and a first pressure sensor for detecting pressure in the transport channel. The connection ring is provided with a bypass circuit connectable to the irrigation or aspiration channel, respectively and the connector including a dead channel connectable to the bypass circuit and a second pressure sensor for detecting pressure in the dead channel.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Abstract: Methods of establishing an insulin delivery rate in a pump and an insulin pump are disclosed. A method includes selecting a set of alerts from one or more sets of alerts. The method also includes initiating a test process based on the set of alerts. The method further includes, upon activation of each alert in the selected set of alerts, prompting a user to input a blood glucose level.

Abstract: A system for operating a semi-closed loop and/or a closed loop resuscitation of a burn patient in view of patient information and other physiological data gathered by the system. The system in at least one embodiment includes an urine sensor, an infusion pump and a processor that controls the operation of the infusion pump at least in part from a signal received from the urine sensor.

Abstract: This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures are also provided.

Abstract: The present invention comprises a sedation and analgesia system having integrated patient monitoring and drug delivery, where information related to monitored patient parameters and drug delivery is accessible and controllable from a remote location. Information relative to monitored patient parameters and drug delivery may be provided in real-time or near real-time, to an attending nurse, physician, insurance company, billing department, or other suitable party according to the present invention via a computing device, video monitor, over the Internet, over an intranet, or by any other suitable means of transmitting and displaying critical data. The present invention further comprises an integrated in-room monitor, where data related to critical patient parameters and drug delivery may be integrated with other means of communicating data related to a patient, a procedure, or a medical device.

Abstract: A method and apparatus for monitoring a cardiovascular pressure signal in a medical device that includes comparing the sensed pressure signal to a first pressure threshold, identifying a first sense greater than the first pressure threshold, determining a metric of the pressure signal in response to the identified first sense, comparing the sensed pressure signal to a second pressure threshold not equal to the first pressure threshold in response to the identified first sense, identifying a second sense, subsequent to the first sense, greater than the second pressure threshold, identifying a third sense, subsequent to the first sense, greater than the first pressure threshold, and determining a cycle length corresponding to electrical activity of a heart in response to one of the first sense and the third sense or the second sense and the third sense.

Abstract: A system for monitoring a concentration of an anesthetic drug using a patient's breath is provided. The system comprises a sampling subsystem for processing the patient's breath to form a breath sample, one or more sensors to measure drug concentration in the breath sample, one or more sensors to measure a concentration of gases in the breath sample; and one or more microprocessors for determining a concentration of the drug in a plasma of the patient using a transfer function and the concentration of the drug in the breath sample. A system for monitoring propofol concentration in patient's breath sample is also provided.

Abstract: A blood sugar level control system for measuring a blood sugar level and administering insulin into a body. The blood sugar level control system includes a blood sugar measuring device having a first wireless data transmitting part to transmit data relating to the blood sugar level; an insulin dispensing device having a wireless data communication unit including a second wireless data transmitting part to transmit data to a second blood sugar measuring device, and a wireless data receiving part to receive data from the first wireless data transmitting part and the second blood sugar measuring device; and an attachment mechanism to couple the insulin dispensing device and the blood sugar measuring device so that the blood sugar measuring device is movable, without separating from the insulin dispensing device at least three specific positions.

Abstract: An infusion system to administer a fluid includes an infusion pump with a pump processor, a pump memory to store a plurality of configurable alarms and a pump radio to enable bi-directional communication. The infusion system further includes a controller that has a controller processor, a controller memory, a controller radio to transmit and receive communication from the pump radio. The controller further has a graphical user interface shown on a display along with controls to manipulate the graphical user interface. Furthermore, the bi-directional communication between the infusion pump and the controller establish an infusion pump relative proximity between the infusion pump and the controller such that when the infusion pump relative proximity exceeds a pump threshold distance at least one of the plurality of configurable alarm conditions of the infusion pump is modified.

Abstract: Methods and systems are described for controlling a flowrate of insulin infused into the body of a patient. An insulin infusion device infuses insulin into the body of the patient. A first sensor generates blood glucose level (BGL) data indicative of a blood glucose level of the patient. A second sensor generates autonomic nervous system (ANS) data such as heart rate data dependent on at least one parameter of the patient's autonomic nervous system. A data fusion processor receives the BGL data and the ANS data and generates an output alarm signal if a hypoglycaemic event is inferred. A flowrate of insulin of the insulin infusion device may be modified dependent on the output alarm signal.

Abstract: A method and apparatus for monitoring a cardiovascular pressure signal in a medical device that includes determining whether the sensed pressure signal is greater than a first pressure threshold, determining a first metric of the pressure signal in response to the sensed pressure signal being greater than the first pressure threshold, determining whether the sensed pressure signal is greater than a second pressure threshold not equal to the first pressure threshold, determining a second metric of the pressure signal in response to the sensed pressure signal being greater than the first pressure threshold, and determining at least one of a systolic pressure or a diastolic pressure, wherein the at least one of a systolic pressure or a diastolic pressure is determined based on the first metric in response to the pressure signal not being greater than the second threshold, and based on the second metric in response to the pressure signal being greater than the second threshold.

Abstract: A medical device is provided comprising a transcutaneous device unit and a process unit. The transcutaneous device unit may comprise a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The process unit may comprise a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the process unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.

Abstract: Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.

Abstract: Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.

Abstract: There is provided an infusion pump system for delivering a predetermined medical solution at a preset reference infusion speed. The system comprises a medical solution container; an infusion line through which the medical solution is drawn out of the medical solution container; an infusion pump configured to discharge the medical solution via the infusion line. The infusion pump is controlled so that the discharge speed of the infusion pump is computed on the basis of a current discharge speed of the infusion pump and the infusion speed of the medical solution, the resulting discharge speed is corrected by a predefined correction coefficient, and the medical solution is discharged at the corrected discharge speed.

Abstract: Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.

Abstract: Problems To provide a cardiac disease treatment system for accurately diagnosing the functional cause of an abnormality of a cardiac disease by analyzing the hemodynamic state of a patient, automatically performing medication in accordance with the diagnosis result, and treating the cardiac disease. Means for solving problems The cardiac disease treatment system is characterized by comprising input means (2) for inputting the cardiac output value of the patient, the left atrial pressure value and/or the right atrial pressure value, first calculating means (31) for calculating the pumping ability value of the left heart or the right heart from the inputted cardiac output and the left or right atrial pressure value, first comparing means (41) for comparing the pumping ability value of the left heart or the right heart with a target pumping ability value, and first medicating means (51) for medicating the patient in accordance with the result of the comparison by the first comparing means (41).

Abstract: Some embodiments of a portable infusion pump system can be configured to can be configured to adjust the sensitivity of particular detectors or alert systems based (at least in part) on information received from a monitoring device. For example, a glucose monitoring device can communication with an infusion pump assembly used to supply insulin or another medication to a user. In such circumstances, the data received from the monitoring device can be used to adjust the sensitivity of an occlusion detection system.

Abstract: A method, system and computer program product for correcting a nominal treatment strategy of a subject with diabetes. The method, system and computer program product may be configured for providing input whereby the input may include: open-loop therapy settings for the subject, data about glycemic state of the subject; and (optionally) data about meals and/or exercise of the subject. The method, system and computer program product may be configured for providing output, whereby the out-put may include an adjustment (correction) to the open-loop therapy settings for the subject for insulin delivery to the subject.

Abstract: Some embodiments of an infusion pump system can include a controller in which one or more features sets to be provided by the controller are enabled or disabled based upon the particular pump device that is connected to the controller. For example, in some embodiments, one or more advanced features of the controller are available to the user only when a first type of pump device (e.g., having predefined settings stored therein) is connected to the controller, and those advanced features of the controller are disabled when a second type of pump device is connected to the controller.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Abstract: An infusion set component for a fluid infusion device that delivers fluid to a patient is presented here. The component includes a tube formed from tubing material having an interior fluid canal defined therein to provide a fluid pathway from the fluid infusion device to the patient, a plurality of sensor conductors incorporated with the tubing material to facilitate sensing of an analyte of the patient by the fluid infusion device, and a combined infusion-sensor unit coupled to the tube and to the plurality of sensor conductors. The infusion-sensor unit accommodates delivery of fluid from the tube, and it also accommodates sensing of the analyte. The component may also include a connector assembly coupled to the tube and to the plurality of sensor conductors, to fluidly couple the fluid canal to a fluid reservoir of the fluid infusion device and to electrically couple the sensor conductors to an electronics module of the fluid infusion device.

Abstract: A medical device system is disclosed. The medical device system includes a first medical device and a second medical device. A remote interface including a touch screen is also included. The remote interface is in wireless communication with the first medical device and the second medical device. The remote interface is configured to provide a user interface to the first medical device and the second medical device. The remote interface is configured to receive user input through a touch screen. Also, a charging device is included. The charging device is configured to receive at least the first medical device and the remote interface and the charging device is configured to recharge a first medical device battery and the charging device is configured to recharge an interface battery in the remote interface. The charging device is connected to a personal computer wherein the personal computer provides information to the remote interface.

Abstract: An apparatus, system, and method for storing liquid from a tissue site are presented. The apparatus includes a delivery tube that may have at least one lumen. The delivery tube may be operable to transmit reduced pressure to the tissue site and to receive liquid from the tissue site. The apparatus may also include an absorbent material disposed in the at least one lumen. The absorbent material may be operable to absorb the liquid from the tissue site. The delivery tube may be formed with a number of recesses.

Abstract: A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect the treatment of a person, such as by initiating, pausing, halting or adjusting the dosage of drugs administered to the person.

Abstract: According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.

Abstract: Methods of regulating blood glucose levels using an insulin pump are disclosed. A method includes receiving a current blood glucose level, and determining whether the current blood glucose level is above a threshold value. The method also includes calculating a correction bolus value based upon the current blood glucose.

Abstract: An analyte sensor and systems for determining analyte levels in a user's body. The analyte sensor and systems are adapted to be used with single dose medication devices and include a communication system to transmit the communications from the analyte sensor to the user to notify the user of an estimated amount of fluid to deliver to the user's body. More particularly, these apparatuses and methods for use are for providing convenient monitoring of blood glucose levels in determining the appropriate amount of insulin to deliver.

Abstract: Methods, systems and devices for detecting an analyte sample, determining an analyte concentration associated with the detected analyte sample, storing the determined analyte concentration and a time associated with the determined analyte concentration, retrieving two or more stored analyte concentrations, and determining an adjusted dose level based at least in part on a current dose level and data associated with the two or more retrieved analyte concentrations are provided. For example, adjustments to dosage levels of long-acting insulin may be provided to assist in the management of diabetes and related conditions.

Abstract: The invention relates to a medical device for infusion of an active ingredient or removal of a body tissue or body liquid comprising: a outlet device for infusion of an active ingredient to a body tissue; a receptacle for storing the active ingredient to which the outlet device is attachable; a sensor device for measuring a parameter which is related to a physical state in the body tissue; a drive device for effectuating at least an infusion of the active ingredient; characterized by a control unit functionally connected to the sensor device for receiving a sensor signal, which corresponds to the state of the body tissue, wherein the control unit is adapted for controlling a flow rate.

Abstract: Safety features are applied to an integrated insulin delivery system to enhance safety while accounting for glucose sensor bias and calibration errors. One safety feature includes comparisons of calibrations of the sensor to nominal sensitivity and taking action, such as limiting insulin delivery or taking a further calibration of the sensor. In another feature, an automatic resumption of a basal delivery rate is programmed into the delivery device to avoid the possibility of complete loss of delivery of insulin in the event that communication with the delivery device is disrupted. Other features include steps taken to avoid hypoglycemia in the event that the sensor is negatively biased.

Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.