Abstract: A patient fluid care system that provides an integrated solution for managing patient fluids by precisely controlling one or more infusion pumps; monitoring real-time patient sensors, and pharmaceutical information; and deriving patient status and the status of pharmaceuticals administer to the patient based upon such monitoring and controlling; and automatically adjusting infusing parameters based upon the real-time patient, infusion, and pharmaceuticals information and derived patient status and the pharmaceuticals levels.

Abstract: A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 26 to compare the detection result from the detection processing circuit with an analytical pattern stored in a pattern storage portion and calculate the peak time of the accumulation concentration in a tissue of a sample in the test bottle.

Abstract: A system includes bio-medical units, a wireless communication module, and a wireless power source. A bio-medical unit includes a power harvesting module, a communication module, a processing module, and a medication control module for performing a medication control function and generating a medication response. The wireless communication module is operable to wirelessly communicate inbound and outbound wireless signals with the bio-medical unit. The wireless power source is operable to generate the electromagnetic signal, which the power harvesting module converts into a supply voltage that powers the other modules of the bio-medical unit.

Abstract: Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.

Abstract: A wearable insulin dispensing device has features and operation characteristics supporting and easing compliance by the users of the device. For example, the device may provide capabilities of rendering a very specific and well-tuned dosage which may be altered according to the specific development of the individual user.

Abstract: Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.

Abstract: The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.

Abstract: Wound fluid blood detection systems and methods are described that are operable in conjunction with reduced pressure wound treatment (RPWT) systems, as well as ancillary therapy and monitoring systems applied concurrently with RPWT systems. The blood detection monitor operates by optically characterizing the content of wound fluids to the extent of identifying percentage blood content. This identification relies upon the transmission of select wavelengths of light across a volume of wound fluid to a photo detector (connected to signal processing instrumentation) capable of quantifying the absorption characteristics of the fluid. The detection components may be implemented in conjunction with either a fluid flow conduit (i.e. the reduced pressure tubing directing fluid away from the wound dressing) or more directly in association with the materials that comprise the wound dressing positioned within the wound bed itself.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more sheaths configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more applicators supported by the one or more sheaths and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.

Abstract: An administration device for the administration of a liquid drug in adjustable doses may comprise an injection unit and an electronic indication unit. The injection unit may comprise a dosing mechanism and a manually operated dose setting component. The manually operated dose setting component may adjust the dosing mechanism to administer an administration dose amount of the liquid drug. The electronic indication unit may indicate a relationship between the administration dose amount and a target dose amount. A method for setting a dose of a liquid drug for administration may comprise providing an administration device, operating a manually operated dose setting component of the administration device, and continuing to operate the dose setting component until an electronic indication unit indicates that the administration dose amount is equal to the target dose amount.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

Abstract: A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

Abstract: A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

Abstract: Some embodiments of a portable infusion pump system can be configured to can be configured to adjust the sensitivity of particular detectors or alert systems based (at least in part) on information received from a monitoring device. For example, a glucose monitoring device can communication with an infusion pump assembly used to supply insulin or another medication to a user. In such circumstances, the data received from the monitoring device can be used to adjust the sensitivity of an occlusion detection system.

Abstract: Embodiments of the present disclosure include methods, systems and devices for selecting a bolus configuration and may include one or more of providing a user interface for selection of one or more user interface elements, where each element corresponds to a bolus configuration of a drug, each element is spatially positioned within a multi-dimensional space corresponding to at least three dimensions and the element's position corresponding to each dimension.

Abstract: An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (time-course of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action.

Abstract: Some embodiments of a wearable infusion pump system can include a pump device having a drive system to dispense a medicine to a user, an activity sensor that detects a possible change in an activity level of the user, and a controller to activate the drive system to dispense the medicine to the user. The controller device can query the user to indicate whether a detected activity level of the user represents an actual change in the activity level of the user. The controller device can alter the medicine dispensing schedule based on the user indicated changes in activity level.

Abstract: A sensor-augmented medication infusion system includes a sensor attached to a body of a user to detect an analyte level of the user. An infusion device is adapted to be carried by the user that includes a drive mechanism operatively coupled to a reservoir containing a fluid to infuse the fluid into the body of the user, a processor operatively coupled to the drive mechanism to control the drive mechanism, a communication receiver operatively coupled to the processor to receive data from the sensor corresponding to the analyte level of the user, and a display screen operatively coupled to the processor to display the data corresponding to the analyte level of the user, wherein the infusion device includes a user-selectable function to disable the infusion device from infusing the fluid into the body of the user while continuing to display the data corresponding to the analyte level of the user on the display screen.

Abstract: A method of programming an infusion device includes receiving an infusion rate for a time period, wherein the time period overlaps with a predefined start of a predefined period of the infusion device. The time period is converted into (1) a first converted time period extending from a start of the time period to the predefined start of the predefined period, and (2) a second converted time period extending from the predefined start of the predefined period to an end of the time period. The infusion device is programmed with the infusion rate for the first converted time period and the second converted time period.

Abstract: A method of configuring an insulin infusion device includes receiving body weight information of a patient or total daily dose (TDD) information of the patient. The insulin infusion device is programmed for operation based on the received information and default rules.

Abstract: A system and method for treating hypotension in a mammal including a measuring device for measuring the blood pressure in a blood vessel having a wireless transmitter therein for emitting a signal when the measured blood pressure moves into a predetermined range. The system also includes an injection device fixed on the skin of a mammal, the injection device having a receiver for receiving the signal emitted from the wireless transmitter, a drug reservoir, a conduit for moving drug from the drug reservoir through the skin upon activation, and an activation device that causes the drug to move from the drug reservoir through the conduit and into the mammal upon receiving the signal emitted from the wireless transmitter.

Abstract: The present invention provides a module for a computer interface including a transducer wherein the transducer receives a measurement value and makes this measurement value available for monitoring an individual's health by means of the computer interface, for example, for monitoring an individual's blood glucose level, wherein the measurement value is obtained by means of a sensor.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: Methods, systems, devices and computer program products for providing maintenance, guidance and/or control of certain systems are disclosed. Typically, in some aspects the systems are complex. Also disclosed are methods, systems, devices and computer program products for providing therapeutic guidance for controlling a subject's circulation. One such method comprises the steps of: (i) determining the subject's present and desired circulatory states as a function of at least mean systemic filling pressure (Pms), heart efficiency (EH) and systemic vascular resistance (SVR); (ii) determining a target direction of a trajectory from the subject's present circulatory state to said subject's desired circulatory state, wherein treatment of the subject so as to traverse the trajectory will cause the subject's circulatory state to move towards a desired circulatory state; and (iii) visually representing the target direction of the trajectory.

Abstract: A device (1) is designed for locating a region which is situated in a body (10). The device has a fluid-filled reservoir (30) which is closed off in a sealed manner by a displaceable plunger (32) and is connected to a hollow puncture needle (20). To measure the pressure prevailing in the fluid, the device has a pressure gauge (40). A signal converter (50) is used to convert a continuous pressure-measurement signal provided by the pressure gauge (40) into a form which is suitable for further processing. A synthesizer (60) is designed to process the converted pressure-measurement signal into a continuous sound signal which is representative of the pressure. If, during a displacement of the puncture needle (20), a needle point (21) reaches the anatomical cavity (15), the result is a readily perceptible change in the sound signal. The device records the pressure-measurement signal over the course of time.

Abstract: A method and system for delivering analgesic drug is disclosed herein. The method comprises: administering analgesic drug to a patient based on input from a patient controlled input device and continuously measuring pain level of a patient with reference to at least one patient parameter. The method further comprises: receiving drug demand from patient through the patient controlled input device and controlling administration of analgesic drug based on the measured pain level and the received drug demand.

Abstract: An implantable medical device system and associated method for use in guiding an acute decompensated heart failure therapy set an optimal fluid status measurement level. A physiological sensor signal sensed by an implantable medical device is used to compute the fluid status measurement. A target rate of change of the fluid status measurement is computed for guiding the therapy.

Abstract: Subject matter disclosed herein relates to a semi-closed loop drug delivery system. In particular embodiments, an amount of insulin to be administered to a patient may be calculated based, at least in part, on one or more blood-glucose measurements obtained from said patient, and an alarm may be initiated in response to the calculated amount of insulin. At least a portion of the calculated amount of insulin may then be injected into the patient in the absence of a response to the alarm within a time limit.

Abstract: Methods and apparatuses for calculating and transmitting medication dosage or bolus information are provided. A blood glucose meter receives a test strip with a sample of the user's blood and measures the user's blood glucose level with a sensor. The meter then calculates a bolus amount that is transmitted to a medication infusion pump using a radio frequency transmitter or transceiver. The infusion pump receives the bolus amount data and then delivers a bolus of medication to the user based on the calculated bolus estimate. The meter may also transmit commands to, and be used to remotely control, the infusion pump.

Abstract: Disclosed is a medical device to treat diabetes. The medical device includes a bolus calculator to determine an insulin bolus based on, at least in part, a glycemic index value associated with an intake to be consumed by a user, the bolus calculator further adapted to determine the insulin bolus using one or more inputs selected from the group consisting of carbohydrate load of the intake, current glucose level of the user, residual insulin of the user, carbohydrate to insulin ratio, insulin sensitivity of the user and target glucose level of the user. The bolus calculator is housed in one or more of, for example, an insulin dispensing pump, a handheld remote control unit for an insulin dispensing pump and/or a handheld glucose monitor.

Abstract: Provided is an extended use self-contained, wearable medical device. The device is preferably configured with an infusion deployment mechanism for variably inserting and retracting an infusion needle to different depths, or completely retracting the infusion needle from the infusion site and then re-inserting the infusion needle after a predetermined period of time, throughout an infusion cycle for extending the viability of the infusion site. Another embodiment comprises dual needle deployment mechanisms which may also variably insert and retract the infusion needles. A flow sensor is preferably provided for detecting the stoppage of flow through the infusion cannula and signaling the needle deployment mechanism to attempt infusion at a different depth or to deploy a second infusion needle. A re-fillable reservoir assembly is preferably provided for supplying a drug over the extended use of the device.

Abstract: Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with a front-loaded delivery algorithm having a fluid delivery period and a refractory period, and determining an appropriate fluid infusion rate in response to the measurements.

Abstract: The inventive endoscopy system includes a cannula for arranging an endoscope and forming, between said cannula and endoscope, an irrigation or aspiration channel for transporting an irrigation or aspiration fluid, respectively, a connection ring mounted around the cannula and provided with a connection channel connectable to the irrigation or aspiration channel, respectively and a connector which is mounted on the connection ring and includes a transport channel with the connection channel and a first pressure sensor for detecting pressure in the transport channel. The connection ring is provided with a bypass circuit connectable to the irrigation or aspiration channel, respectively and the connector including a dead channel connectable to the bypass circuit and a second pressure sensor for detecting pressure in the dead channel.

Abstract: A medication, method and device for cardiac treatment are provided, in particular, for treating supraventricular arrhythmias. Specifically, a method is provided for treating supraventricular arrhythmias, using a therapeutically effective amount of a cholinergic receptor agonist, for example, acetylcholine. This device may be part of universal device which provides pacing and defibrillation. In particular, the present invention can be used to treat atrial fibrillation, atrial flutter and atrial tachycardia by a bolus injection of a rapidly hydrolysable cholinergic receptor agonist such as acetylcholine.

Abstract: The present disclosure provides a contamination resistant sensor port which includes one or more sealing members positioned so as to limit and/or prevent internal contamination of the sensor port with fluids and/or particles present in the environment outside the sensor port.

Abstract: A medical remote controller device is disclosed. The device includes a display and at least one input switch dedicated to bolus delivery wherein a bolus delivery is programmed when the input switch receives an input and wherein the number of inputs received by the input switch determines the amount of bolus to be delivered.

Abstract: A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings.

Abstract: Methods and systems for treating Hepatitis C infections are provided. Typically the method comprises administering interferon-? to the patient subcutaneously using a continuous infusion apparatus, wherein this therapeutic regimen is sufficient to maintain circulating levels of interferon-? in the serum of the patient above a target concentration for a certain period of time.

Abstract: A method for providing decision-assist to medical staff resuscitating a burn patient includes receiving patient information, calculating an infusion rate, outputting the infusion rate, obtaining a urinary output, calculating a new infusion rate using infusion rate model based constants, and outputting the new infusion rate. In some embodiments, the method includes notifying medical staff when problems arise, displaying information regarding the resuscitation, and setting limits regarding the infusion rates.

Abstract: A device includes a first reservoir configured to include a degradation agent, a first control element configured to provide access to the first reservoir, and an expandable component configured to extend to engage an osteal structure.

Abstract: Provided is a wearable, self-contained drug infusion or medical device capable of communicating with a host controller or other external devices via a personal area network (PAN). The medical device utilizes a PAN transceiver for communication with other devices in contact with a user's body, such as a physiological sensor or host controller, by propagating a current across the user's body via capacitive coupling. The wearable nature of the medical device and the low power requirements of the PAN communication system enable the medical device to utilize alternative energy harvesting techniques for powering the device. The medical device preferably utilizes thermal, kinetic and other energy harvesting techniques for capturing energy from the user and the environment during normal use of the medical device. A system power distribution unit is provided for managing the harvested energy and selectively supplying power to the medical device during system operation.

Abstract: A first drug delivery system includes first and second drug-container holders and first and second pump assemblies. The first (second) holder is adapted to receive a first (second) drug container having a first (a different second) dimensioned shape but not a second (first) drug container having a different second (a first) dimensioned shape. A second drug delivery system includes first and second bar code scanners, first and second drug-container holders, and first and second pump assemblies. The first (second) holder is adapted to receive a first (second) drug container having a dimensioned shape and to orient a positioned first (second) bar code of the first (second) drug container to face the first (second) bar code scanner because of the dimensioned shape. In one application, the first drug is a sedative drug, the second drug is an analgesic drug, and the drugs are used during a conscious sedation medical procedure.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.

Abstract: In a patient controlled analgesia (PCA) system, physiological data is processed and alarms are provided by the controller of the physiological module sensing the data according to a first rule. The physiological data is also processed by a second, separate controller according to a second rule independent from the first controller. According to the second rule, the physiological data may be filtered, processed with physiological data and non-physiological data obtained from another source, such as a remote server, and the PCA delivery device controlled to prevent delivery of medication accordingly. The provided system of multiple processors and rules enables normal alarming by physiological sensor modules while the pausing or prevention of the PCA delivery is controlled by a separate controller. Through this means, not only are false pauses and alarms for PCA delivery reduced, but the normal alarms of the monitors are permitted to function normally.

Abstract: A system for delivering or withdrawing a fluid to or from the body of a patient in a manner that permits delivery to be controlled based upon feedback from the patient, the system including a syringe assembly providing a syringe operably coupled to one or more sensors adapted to determine one or more corresponding parameters associated with fluid delivery and/or withdrawal, and a monitor adapted to be communicably associated with the one or more sensors of the syringe assembly, and optionally with other sensors or inputs providing additional parameters as well, the monitor comprising one or more read out mechanisms either directly or indirectly corresponding to the one or more fluid delivery/withdrawal parameters, and optionally with one or more of the additional parameters as well.

Abstract: A medical device system includes a portable (patient-worn or patient-carried) medical device that can automatically initiate certain e-commerce and/or advertisement presentation features in response to the detection of one or more triggering events. A triggering even may, for example, be associated with the monitoring of the operation or status of the medical device, the operation or status of the medical device system, a medical condition of the patient, treatment of the patient, and/or the preferences of the patient or user. In one application, the medical device is an insulin infusion pump and the user is automatically prompted to purchase, order, or otherwise obtain replaceable or replenishable items associated with the operation of the insulin infusion pump, such as a continuous glucose sensor, an infusion set, or an insulin reservoir.

Abstract: In a medical device having a display element, a method of providing an intuitive graphical display of patient data begins by obtaining measurement data corresponding to values of a physiological characteristic measured over a period of time. The method continues by rendering a graphical representation of a portion of the measurement data on the display element, resulting in a display of the values of the physiological characteristic measured during a first interval of the period of time. Thereafter, the method processes a user-initiated display panning command and, in response to the user-initiated display panning command, dynamically pans the graphical representation while updating the portion of the measurement data. Thereafter, the method renders a display of the values of the physiological characteristic measured during a second interval of the period of time.

Abstract: Described is an infusion pump comprising electronic infusion regulating means with wired or wireless communication means and a power source, a medicament bag (7) and an infusion device, said infusion device being in fluid communication with said medicament bag (7) and comprising two valves (1, 2), a pressure cavity (4) provided between said two valves (1, 2) and a membrane (3) covering said cavity (4), wherein said infusion device comprises at least two active actuators, preferably either made of electroactive polymer so as to form a self actuating membrane (3) or made of shape memory alloy wire, one of said actuators being adapted to apply pressure to said membrane (3) for fluid displacement in said cavity (4), and the other of said actuators being adapted to operate one of said valves which is adapted to passively close in the flow direction of a fluid from said medicament bag (7) through the cavity (4), wherein the other of said valves is adapted to, in particular passively, close in a direction opposite t