Material Expelled From Injector By Pressurized Fluid Patents (Class 604/70)
  • Patent number: 11890453
    Abstract: Devices and methods are provided for delivering an agent into a patient's body using an injection device that includes a drive module and an injector module coupled to the drive module. The drive module includes a canister and puncture mechanism in a first chamber, a plunger in a second chamber communicating with the first chamber, and an actuator that moves the puncture mechanism to cause a puncture pin thereon to penetrate a septum of the canister and cause the gas within the canister to flow through the first chamber around the canister, and into the second chamber. The injector module includes a piston slidably disposed within an agent chamber and coupled to the distal end of the plunger such that, when the plunger moves from a retracted position to an extended position, the piston is advanced within the agent chamber to deliver an agent therein into a patient's body.
    Type: Grant
    Filed: May 9, 2020
    Date of Patent: February 6, 2024
    Assignee: ALTAVIZ, LLC
    Inventors: Jack R. Auld, Andrew Schieber, Matthew McCawley, Matthew Flowers, Yule Kim, Marcus Souza
  • Patent number: 11712521
    Abstract: An injection nozzle for a needleless injection device includes at least one outlet conduit extending parallel to an injection axis (B). The outlet conduit(s) include a first conduit portion having a first section, a second conduit portion having a second section, the first section being larger than the second section, and a connecting portion between the first conduit portion and the second conduit portion. The connecting portion is inclined at an angle between 70° and 90° with respect to the injection axis (B).
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: August 1, 2023
    Assignee: CROSSJECT
    Inventors: Christophe Auriel, Patrick Alexandre, Benoit Guichard, Jennifer Ascani, M. Abdel Tazibt
  • Patent number: 11607490
    Abstract: The present disclosure relates in one aspect to a measuring arrangement for measuring a volume occupied by a liquid medium inside a liquid reservoir, the measuring arrangement including a container having an interior volume containing a gas reservoir filled with a gaseous medium and containing a liquid reservoir filled with a liquid medium, wherein the gas reservoir and the liquid reservoir are hermetically separated by an impenetrable separation wall, a volume modulator to induce a volume change of the gas reservoir, a pressure sensor arranged inside the gas reservoir to measure a pressure change of the gaseous medium in response to the volume change of the gas reservoir, and a controller connectable to the pressure sensor, wherein the controller is configured to calculate the volume of the liquid reservoir on the basis of the pressure change and the volume change.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: March 21, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Rene Richter, Robert Witt, Richard Guenther, Thomas Nagel
  • Patent number: 11464892
    Abstract: A method of delivering a therapeutic substance for treatment to a region of the body through vascular isolation and manipulation of fluid flux into and from the region of the body including the steps of: restricting vascular inflow to the region of the body; washing out oncotically active plasma proteins from the region of the body by increasing the outward oncotic pressure gradient from the region of the body; inducing ischemia in the region of the body; controlling the pressure and fluid flow of the main blood vessels to and from the region of the body; providing the therapeutic substance to the region of the body when the fluid flow to the region of the body is controlled.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: October 11, 2022
    Assignee: All Vascular Pty Limited
    Inventors: Rodney James Lane, Matthew James Huckson, Chris Kyung, David Lane, Nyan Khin, Scott Murphy
  • Patent number: 11351307
    Abstract: A drug delivery system is provided that has an adjustable dose mechanism allowing setting and locking the dose then administration of the set dose. A method for administering a medicament using the drug delivery system is also provided.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 7, 2022
    Assignee: Beloteca Investment Fund 1, LLC
    Inventor: Lawrence J. Kelly
  • Patent number: 11229755
    Abstract: A medical gas condition system for supplying a liquid hydration fluid to a hydrator before or during an ongoing medical procedure by coupling the flow of liquid hydration fluid into the hydrator to either the absence of flow of medical insufflation gas into the hydrator or to a condition where the liquid hydration fluid can be absorbed by a hydrator without being forced through the hydrator in liquid form.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: January 25, 2022
    Assignee: LEXION MEDICAL, LLC
    Inventors: Douglas E. Ott, Nathanial Tran
  • Patent number: 11202862
    Abstract: A device and a method for adjustable quantitative injection of high-pressure gas are provided, wherein the gas may have a pressure of 5 MPa or more than 5 MPa. The gas may be directly communicated with a gas tank in the mechanism or an external gas source, flows through corresponding valves, and is charged into a predetermined or adjustable reservoir. Alternatively, the valve may be time-controllable, and does not need the reservoir. The gas is ejected through a nozzle selected based on depth or range of injection, wherein a one-way valve is disposed between the nozzle and the body to prevent contamination due to backflow. The manipulator can exert an appropriate force onto a target portion of a human for gas injection, and when the injection is done, a biasing member can automatically return the mechanism to its original state, ready for the next injection.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: December 21, 2021
    Inventor: Guo-Luen Huang
  • Patent number: 11123492
    Abstract: An injection device comprises an actuator adapted when actuated to cause commencement of an injection sequence; a locking mechanism adapted to be moved between a locked position in which the locking mechanism prevents the actuator from being actuated, and an unlocked position in which the actuator can be actuated to cause commencement of the injection sequence. An indicator is configured to provide a visual indication of whether the locking mechanism is in its locked position or in its unlocked position.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: September 21, 2021
    Assignee: Cilag GmbH International
    Inventors: Douglas Ivan Jennings, Ahmad Bitar
  • Patent number: 11103656
    Abstract: Disclosed is an inhalation device which comprises a housing having a removable therein. The vial will contain such liquid as phyto-cannabinoids, cannabidiol, terpenoids, aromatherapy, or tetrahydrocamiabinol. A conveyance tube in the housing communicate with the interior of the vial and has therein a material for conveying the distillates by capillary action to a vaporization chamber. The conveyance tube has a conically shaped head for puncturing THC membrane. The liquid in the vial to passes from the conveyance tube into a vaporization chamber. The vaporization chamber, which is also in the housing, has attached to it a heating device for vaporizing the liquid. The vaporized liquid then passes through vents in the vaporization chamber housing and within the main housing so as to be available to be drawn out through a mouthpiece which is in turn secured to the housing.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: August 31, 2021
    Inventor: Derek Domenici
  • Patent number: 10940306
    Abstract: A connector for transferring fluid and method therefor. The connector may have a first port and a second port which may be coupled together at a main channel with a valve element therein controlling fluid flow through the first port. The first port joins the main channel to provide a fluid path around the valve element and through the second port.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: March 9, 2021
    Assignee: CareFusion 303, Inc.
    Inventors: Tim L. Truitt, Alex Truman Mazza, Cliff Colwell, Jonathan Yeh, Christopher J. Zollinger, Matthew Quach, George Michel Mansour
  • Patent number: 10918791
    Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: February 16, 2021
    Assignee: kaleo, Inc.
    Inventors: Evan Thomas Edwards, Eric Shawn Edwards, Mark J. Licata
  • Patent number: 10905830
    Abstract: An automatic injection device for fluid has a sleeve, an actuating unit, a barrel with a piercing needle, a high-pressure air source and a driven unit. The actuating unit is mounted in the sleeve. The high-pressure air source and the driven unit are mounted slidably in the barrel. The barrel, the high-pressure air source and the driven unit are first mounted in the sleeve to be ready for use. When the user needs to release the high-pressure air in the high-pressure air source, the user press the actuating unit to drive the driven unit to slide. Then the driven unit also drives the high-pressure air source to slide until the high-pressure air source hits the piercing needle. Therefore, the high-pressure air in the high-pressure air source is easily released by actuate the actuating unit without additional hand tools.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: February 2, 2021
    Assignee: BANZA STAMPING INDUSTRY CORP.
    Inventors: Li-Wei Chen, Cole Krebs
  • Patent number: 10835679
    Abstract: A needleless injector includes a cap, an injection system, a body, a gas generator, and a percussion device. The body is covered by the cap and is mounted to slide relative to the cap. The percussion device includes a striker that is slidingly mounted along a sliding axis between a rest position and a percussion position and a lock mechanism. The lock mechanism includes a lug and a retention tab. The lug projects from a peripheral face of the striker along an axis that is perpendicular to the sliding axis and has a first support ramp. The retention tab is attached to the cap, and has a second support ramp. The ramps are configured to move the retention tab radially when pushed by the striker from a retaining position to a release position and the retention tab is moved aside to release the striker.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 17, 2020
    Assignee: CROSSJECT
    Inventors: Gilles Vivien, Xavier Vigot
  • Patent number: 10792427
    Abstract: Described herein are assisted syringes. The syringes provide a higher force to the plunger tip than the extrusion force applied to the plunger. The assisted syringes can be used to inject or extrude viscous materials.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: October 6, 2020
    Assignee: Allergan, Inc.
    Inventors: Jason S. Metzner, Zachary Dominguez, Justin J. Schwab, Ethan Franklin, Mike Augarten
  • Patent number: 10603095
    Abstract: A method for the selective elevation and separation of tissues comprised of multiple layers and a surgical instrument for performing the method. The method may be performed without the requirement of a solid mechanical device insertion or transection through the mucosal layer. In particular, the method and surgical instrument may be used for the selected separation and/or resection of selected portions of benign or malignant tissues (e.g. defining tissue planes, polyp elevation and removal, submucosal tissue tunnelling, endoscopic mucosa resection, etc).
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: March 31, 2020
    Assignee: Erbe Elektromedizin GmbH
    Inventors: Klaus Fischer, Dan Maurice, John Day, Markus Enderle
  • Patent number: 10507285
    Abstract: Apparatus and method are described employing pressurized gas to transfer, mix and/or reconstitute medicament contained in a vial and flowing it into an injection device. Pressurized gas may be provided by prefilled cartridge.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: December 17, 2019
    Assignee: Enable Injections, Inc.
    Inventors: Adam Dunki-Jacobs, Michael D. Hooven, Matthew J. Huddleston, Richard P. Nuchols, Joetta Renee Palmer, David Stefanchik
  • Patent number: 10384011
    Abstract: Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 20, 2019
    Assignee: Powder Pharmaceuticals Incorporated
    Inventor: Victor K. Tsui
  • Patent number: 10350059
    Abstract: An ocular implant insertion apparatus that includes a plunger driver that is not manually powered and ocular implant insertion methods. There are a variety of instances where an ocular implant is inserted into the anterior chamber, posterior chamber, cornea, vitreous space and/or other portion of an eye. Exemplary ocular implants include, but are not limited to, lenses, capsular tension rings, ocular prosthesis and lamellar transplants.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: July 16, 2019
    Assignee: Hoya Corporation
    Inventors: Jim Deacon, John Scholl, Takashi Ichinohe, Thomas McNicholas, Christopher James Glaister, Christopher A. Wilson, Phillip C. Halbert
  • Patent number: 10071203
    Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: September 11, 2018
    Assignee: kaleo, Inc.
    Inventors: Evan Thomas Edwards, Eric Shawn Edwards, Mark J. Licata
  • Patent number: 10071204
    Abstract: Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: September 11, 2018
    Assignee: Powder Pharmaceuticals Incorporated
    Inventor: Victor K. Tsui
  • Patent number: 9724191
    Abstract: An intraocular lens inserter can include an energy storage portion, an actuator portion, and a lens support portion. The energy storage portion can include a compressible energy storage device, such as a compressible fluid, springs, and other devices. The inserter can include an actuator portion operating with a substantially incompressible fluid, such as liquids or other noncompressible fluids. The actuator can be configured to provide an operator with control over the release of energy from the energy storage portion so as to move a plunger for the discharge of a lens from an intraocular lens cartridge.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: August 8, 2017
    Assignee: Alcon Pharmaceuticals, Ltd.
    Inventor: Jack R. Auld
  • Patent number: 9498407
    Abstract: A disposable nozzle for use on the discharge end of the barrel of a needleless injector is threaded onto the front end of a holder mounted in the barrel. A resilient detent extending outwardly at an acute angle from the inner wall of a recess in the rear end of the nozzle repeatedly enters and exits notches in a sleeve on the holder when the nozzle is mounted on the holder providing an audible signal that the nozzle has not been used. Reverse rotation of the nozzle during removal from the holder results in breaking of the detent. Thus, mounting of a used nozzle on the holder would not be accompanied by a signal that the nozzle is unused.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: November 22, 2016
    Assignee: Medical International Technologies (MIT Canada) Inc.
    Inventor: Karim Menassa
  • Patent number: 9468486
    Abstract: A method for the selective elevation and separation of tissues comprised of multiple layers and a surgical instrument for performing the method. The method may be performed without the requirement of a solid mechanical device insertion or transection through the mucosal layer. In particular, the method and surgical instrument may be used for the selected separation and/or resection of selected portions of benign or malignant tissues (e.g. defining tissue planes, polyp elevation and removal, submucosal tissue tunneling, endoscopic mucosa resection, etc).
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: October 18, 2016
    Assignee: ERBE ELEKTROMEDIZIN GMBH
    Inventors: Klaus Fischer, Dan Maurice, John Day, Markus Enderle
  • Patent number: 9457151
    Abstract: The present invention relates to a needleless drug-injecting system and a drug-injecting method thereof, wherein the needleless drug-injecting system comprises a controlling device and a needleless drug-injecting device. By using the needleless drug-injecting system and the drug-injecting method, a user is able to individually set a variety of parameters comprising usage dose of liquid medicine, shot pressure of liquid medicine, air flow rate, single-shot quantity of liquid medicine, continuous shot frequency of liquid medicine, and a continuous shot spacing time according to different liquid medicine. Thus, after setting the parameters, the liquid medicine can be injected into the dermis layer of the face skin of a human when the user using this needleless drug-injecting system to inject any one liquid medicine to the human face, therefore the liquid medicine would be absorbed by the face skin without hurting the human face.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: October 4, 2016
    Assignee: GOLD NANOTECH INC.
    Inventor: Shan-Wen Tan
  • Patent number: 9427532
    Abstract: An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: August 30, 2016
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Dominique M. Freeman, Don Alden
  • Patent number: 9370622
    Abstract: Systems, devices, and methods for delivering therapeutic particles are disclosed. In one variation, a device for delivering particles includes a gas supply configured for supplying gas under pressure, a particle cassette comprising the particles, a cassette housing, and a cassette membrane. The cassette housing can comprise an Ethylene Vinyl Acetate (EVA) copolymer of 18% to 28% by weight of Vinyl Acetate (VA). The device can also include a safety interlock to prevent or minimize the risk that the device will be unintentionally activated. The device can also have a silencer.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 21, 2016
    Assignee: Powder Pharmaceuticals Incorporated
    Inventor: Victor K. Tsui
  • Patent number: 9265888
    Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: February 23, 2016
    Assignee: ZOGENIX, INC.
    Inventors: Brooks M. Boyd, Jeffrey A. Schuster
  • Patent number: 9233207
    Abstract: A device, system and method for treatment of tissue by direct application thereto of therapeutic substances in the form of a stream of therapeutic droplets carried in a high velocity gas. The high velocity gas is produced by accelerating a flow of gas through at least one gas discharge nozzle. At least one flow of therapeutic liquid is introduced into the high velocity gas through at least one liquid discharge nozzle, thereby fragmenting the at least one flow of therapeutic liquid into a stream of therapeutic droplets. The stream is accelerated to a velocity similar to the velocity of the gas discharge flow. The accelerated therapeutic droplet stream is then applied to a tissue mass for therapeutic treatment. The therapeutic substances are provided by containers mounted directly on the device. The containers contain predefined dosages and/or concentrations of the therapeutic substances.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: January 12, 2016
    Assignee: TAVTECH LTD.
    Inventors: Alexander Polyakov, Yitzhak Yaniv
  • Patent number: 9067020
    Abstract: A needleless injector syringe includes a tubular barrel containing a first chamber for receiving a liquid, a nozzle on a front end of the barrel, a piston which drives a plunger for discharging the liquid through the nozzle, a second chamber in which the piston slides, a third chamber in fluid communication with the second chamber for receiving gas from said second chamber during forward movement of the piston, and for carrying gas to the second chamber to cause the piston to retract, and a breach plug closing a rear end of the barrel for directing gas under pressure alternately against the rear end of the piston and to the third chamber for driving the piston between the discharge position and a retracted position.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: June 30, 2015
    Inventors: Karim Menassa, Maurice Menassa, Adam Gadoua
  • Patent number: 9044545
    Abstract: A fluid applicator is fed by a fluid delivery arrangement containing an energy storage such as a pressure vessel. The gas pressure acts on a container that has been prefilled with the ejection fluid. The fluid to be ejected is thus subject to constant pressure. With a valve, the user can initiate the ejection of the desired amount of fluid with constant intensity. The check valve may also be a regulating valve which can be used by the user to vary the intensity of the effect. The user need only release the system, e.g., by puncturing the pressure vessel, to then be able to directly inject the fluid in a defined or metered manner via the probe, i.e., the fluid applicator. It is also possible to configure the entire injection device as a single-use system and to prefill the fluid applicator up to its fluid exit opening.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: June 2, 2015
    Assignee: ERBE ELEKTROMEDIZIN GMBH
    Inventors: Martin Hagg, Ralf Kühner
  • Publication number: 20150141952
    Abstract: Described are devices and methods related to the needleless injection of fluid into tissue of the lower urinary tract, such as the urethra and prostate.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 21, 2015
    Inventors: Vincent G. Copa, Sidney F. Hauschild
  • Patent number: 9017282
    Abstract: A high-pressure fluid injection system, which includes a rechargeable injection chamber with a proximal end, a distal end, and an internal opening extending from the proximal end to the distal end, a plunger slideably engaged with the internal opening of the injection chamber, an injection tube extending from the distal end of the injection chamber and in fluidic communication with the internal opening of the injection chamber, and a check valve between the proximal and distal ends of the injection chamber. The internal opening includes a high-pressure zone adjacent to the check valve and having a first diameter, and a low-pressure zone proximal to the high-pressure zone and having a second diameter that is larger than the first diameter.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: April 28, 2015
    Assignee: AMS Research Corporation
    Inventor: Justin M. Crank
  • Patent number: 8986244
    Abstract: A method of treating a prostate condition, including the steps of providing a needleless injector that includes a body at a proximal end, an injection shaft extending from the body to a distal end of the injection shaft, an injection orifice at the distal end of the injection shaft and positioned for fluid ejection in a lateral direction relative to a longitudinal axis of the injection shaft, a pressure source in communication with the fluid chamber, and an extendable tissue tensioner located at the distal end of the injection shaft proximal to the injection orifice; inserting the injection shaft into a urethra so the injection orifice is located within the prostatic urethra; actuating the tissue tensioner to contact urethral tissue, and injecting fluid from the injection orifice into the prostate.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: March 24, 2015
    Assignee: AMS Research Corporation
    Inventors: Vincent G. Copa, Sidney F. Hauschild
  • Publication number: 20150051574
    Abstract: The present invention relates to a needleless drug-injecting system and a drug-injecting method thereof, wherein the needleless drug-injecting system comprises a controlling device and a needleless drug-injecting device. By using the needleless drug-injecting system and the drug-injecting method, a user is able to individually set a variety of parameters comprising usage dose of liquid medicine, shot pressure of liquid medicine, air flow rate, single-shot quantity of liquid medicine, continuous shot frequency of liquid medicine, and a continuous shot spacing time according to different liquid medicine. Thus, after setting the parameters, the liquid medicine can be injected into the dermis layer of the face skin of a human when the user using this needleless drug-injecting system to inject any one liquid medicine to the human face, therefore the liquid medicine would be absorbed by the face skin without hurting the human face.
    Type: Application
    Filed: January 9, 2014
    Publication date: February 19, 2015
    Applicant: Gold NanoTech Inc.
    Inventor: Shan-Wen Tan
  • Publication number: 20150038789
    Abstract: A non-metal, polymeric tubular device for delivering a therapeutic fluid to a treatment site within a patient. The non-metal, polymeric tubular device can be fabricated using suitable high strength polymers and in some versions can be reinforced through the inclusion of reinforcement materials or braiding. The non-metal, polymeric tubular device can be fabricated so as to have a burst strength exceeding at least about 2,000 psi. The non-metal, polymeric tubular device can be fabricated so as to have distention properties, wherein an orifice or jet port located at a distal end of the polymeric tubular device retains its shape and/or size without suffering swelling that can have a detrimental impact on a fluid jet used to deliver the therapeutic fluid at the treatment site.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Inventor: Justin M. Crank
  • Patent number: 8905966
    Abstract: The present invention relates to a novel type of a needle-free drug delivery system in which strong energy such as a laser beam is focused inside liquid contained in a sealed pressure chamber to cause bubble growth and the volume expansion in the sealed pressure chamber due to the bubble growth so as to elongate an elastic membrane, so that an instantaneous pressure is applied to a drug solution contained in a drug microchamber adjacent to the elastic membrane to allow the drug solution to be injected in the form of a liquid microjet, thereby enabling the drug solution to rapidly and accurately penetrate into the bodily tissues of the patient.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: December 9, 2014
    Assignee: SNU R & DB Foundation
    Inventors: Jai-Ick Yoh, Tae-Hee Han
  • Publication number: 20140308352
    Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.
    Type: Application
    Filed: March 11, 2014
    Publication date: October 16, 2014
    Applicants: ZOGENIX INC., DURECT CORPORATION
    Inventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
  • Publication number: 20140296777
    Abstract: The present invention resides in a needleless syringe for injecting an injection objective substance into an injection target area of a living body without using any injection needle; the needleless syringe comprising a main syringe body; an accommodating unit which accommodates the injection objective substance by the aid of a sealing member in an accommodating chamber provided in the main syringe body; a pressurizing unit which pressurizes the injection objective substance accommodated in the accommodating unit to move or destroy the sealing member thereby so that the injection objective substance is discharged to outside; a flow passage unit which forms a discharge port with respect to the injection target area and which defines a flow passage so that the injection objective substance pressurized by the pressurizing unit is discharged via the discharge port to the injection target area; and a preparatory filling unit which fills the flow passage unit with a part of the injection objective substance accommo
    Type: Application
    Filed: February 3, 2012
    Publication date: October 2, 2014
    Applicant: DAICEL CORPORATION
    Inventors: Masahiro Haitsuka, Masayuki Ueda
  • Publication number: 20140276534
    Abstract: A needleless injector includes an injector body having first and second opposite ends. There is a first piston disposed within the body. A second piston may also be disposed within the body configured with a second end for housing a nozzle. There is a medicine inlet for receiving medicine and a pressurized fluid inlet for receiving pressurized fluid. There is also a trigger for releasing the pressurized fluid to drive the first piston thereby driving the medicine through the nozzle for needleless delivery.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Applicant: Nova Pneumatics LLC
    Inventor: Michael Wood
  • Patent number: 8821434
    Abstract: A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: September 2, 2014
    Assignee: Massachusetts Institute Of Technology
    Inventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan
  • Patent number: 8814851
    Abstract: A thermal ablation system comprises a fluid handling unit receiving fluid from a fluid source at a first pressure, the fluid handling unit including a heater heating the fluid to a desired temperature and a pump and an introducer including a sheath which, when in an operative position, is received within a hollow organ, the sheath including a delivery lumen introducing fluid heated by the heater to the hollow organ and a return lumen withdrawing fluid from the hollow organ and returning the withdrawn fluid to the console via a return lumen, wherein the pump increases a pressure of the fluid between the fluid source and the delivery lumen of the introducer.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: August 26, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Robert J. Bouthillier, Michael P. Fusaro, Joseph M. Gordon, Stephen S. Keaney, Brian MacLean, Andrew W. Marsella, David Robson, Boris Shapeton
  • Patent number: 8808232
    Abstract: A needleless injector including a body including a fluid chamber; an outer shaft extending from an outer shaft proximal end to an outer shaft distal end, wherein the outer shaft includes an outer shaft lumen to accommodate an injection shaft; an injection shaft located within the outer shaft lumen and moveable lengthwise and/or rotationally within the outer shaft lumen, wherein the injection shaft includes an injection shaft proximal end, an injection shaft distal end, an injection shaft terminus, and an injection lumen. The injector further includes an injection orifice at the distal end of the injection shaft and in fluid communication with the fluid chamber through the injection lumen; a pressure source in communication with the fluid chamber; and an optical device that allows viewing a location at a distal end of the device.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: August 19, 2014
    Assignee: AMS Research Corporation
    Inventors: Vincent G. Copa, Sidney F. Hauschild
  • Publication number: 20140221916
    Abstract: An injector (10) for injecting a medicament into a patient. The injector includes a container (18) defining a first chamber (22), which contains a fluid therein, and a second chamber (23). The injector also includes an injection conduit (126) configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source (62) is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.
    Type: Application
    Filed: April 4, 2014
    Publication date: August 7, 2014
    Applicant: ANTARES PHARMA, INC.
    Inventors: Thomas E. KRAMER, Peter L. SADOWSKI
  • Publication number: 20140180204
    Abstract: An apparatus for treating tissue of a mammalian body. In one embodiment, a spring mechanism is carried by first and second tubular members and actuatable for moving a needle from a first position disposed within the distal extremity of the first tubular member to a second position extending distally of the first tubular member. In another embodiment, a nozzle is coupled to the distal extremity of an elongate tubular member for delivering a material into tissue of the mammalian body. In a further embodiment, a flexible elongate member provided with a recess is introduced into a cavity of the body to capture tissue in the recess and electrical energy is applied to such tissue in the recess so as to change the compliance of the tissue.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Kurt A.E. Geitz, Katie L Krueger, Joseph A Levendusky
  • Patent number: 8740838
    Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: June 3, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian D. Hemond, Ian W. Hunter, Andrew J. Taberner, Dawn M. Wendell, N. Catherine Hogan
  • Patent number: 8734384
    Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: May 27, 2014
    Assignee: Zogenix, Inc.
    Inventors: Brooks Boyd, Jeffrey A. Schuster
  • Publication number: 20140142536
    Abstract: A fluid applicator is fed by a fluid delivery arrangement containing an energy storage such as a pressure vessel. The gas pressure acts on a container that has been prefilled with the ejection fluid. The fluid to be ejected is thus subject to constant pressure. With a valve, the user can initiate the ejection of the desired amount of fluid with constant intensity. The check valve may also be a regulating valve which can be used by the user to vary the intensity of the effect. The user need only release the system, e.g., by puncturing the pressure vessel, to then be able to directly inject the fluid in a defined or metered manner via the probe, i.e., the fluid applicator. It is also possible to configure the entire injection device as a single-use system and to prefill the fluid applicator up to its fluid exit opening.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 22, 2014
    Applicant: ERBE Elektromedizin GmbH
    Inventors: Martin Hagg, Ralf Kühner
  • Patent number: 8663158
    Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: March 4, 2014
    Assignee: Zogenix, Inc.
    Inventors: William Henry, Andrew Lewis
  • Patent number: 8636704
    Abstract: Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: January 28, 2014
    Assignee: AbbVie Biotechnology Ltd
    Inventors: Sherwin S. Shang, Esra Ozdaryal, Marc M. Plew, William P. Szechinski
  • Publication number: 20140018730
    Abstract: The invention relates to a dosing mechanism for a fluid, comprising an inlet, an outlet, a dosing pipe and two valve groups with an inlet valve and an outlet valve each, wherein the inlet is connected to both inlet valves and the outlet is connected to both outlet valves, wherein the inlet valve of one group is arranged to connect the inlet to a first end of the dosing pipe while the outlet valve of the same group is arranged to connect the outlet to a second end of the dosing pipe, wherein the inlet valve of the other group is arranged to connect the inlet to the second end of the dosing pipe while the outlet valve of the same group is arranged to connect the outlet to the first end of the dosing pipe, wherein control means are arranged to open only the valves of one group at a time thereby allowing the fluid to flow from the inlet through the dosing pipe to the outlet, wherein a dosing object is arranged in the dosing pipe in a manner to be translated from one end towards the other by the fluid, wherein a d
    Type: Application
    Filed: March 28, 2012
    Publication date: January 16, 2014
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Stephan Müller-Pathle