Material Expelled From Injector By Pressurized Fluid Patents (Class 604/70)
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Patent number: 7976494Abstract: A device for administering a fluid product, the device including a first housing part provided with a receiver for the product, a second housing part detachably connectable to the first housing part, a piston rod held such that it can be displaced for the exertion of an emptying movement, an actuatable or releasable drive element for the piston rod, a coupling element including a coupling input element that couples the drive element to the piston rod in a coupling engagement, transmits a driving force of the drive element to the piston rod, and triggers the emptying movement, and a decoupling element displaceably connected to the second housing part and coupled to the first housing part such that it is displaced, by a movement of the housing parts in relation to each other when the housing parts are separated into a decoupling position wherein the piston rod is decoupled from the coupling input element.Type: GrantFiled: June 27, 2007Date of Patent: July 12, 2011Assignee: TecPharma Licensing AGInventors: Philippe Kohlbrenner, Daniel Kuenzli, Christoph Meier, Peter Stettler, Juergen Wittmann, Martin Wittwer
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Publication number: 20110166549Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.Type: ApplicationFiled: December 3, 2010Publication date: July 7, 2011Applicant: Massachusetts Institute of TechnologyInventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan
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Patent number: 7972321Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.Type: GrantFiled: March 19, 2008Date of Patent: July 5, 2011Assignee: ICU Medical, IncInventor: Thomas F. Fangrow
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Publication number: 20110137281Abstract: A drug delivery device mainly has a housing, which can be easily held and operated. The housing has one end formed with an adjustment seat capable of adjusting a range distance, and the other end connected to a gas pressure control source for providing mainstream and substream gas pressures. Disposed in the housing are a drug delivery pressuring tube, an embedded drug-can connecting seat or an external drug-can connecting seat, a replaceable drug-can container and a gas communication tube. According to this design, the minor liquid drug can be controlled, the drug-can can be replaced and the continuous quantitative injection of drug can be made. Also, all damaged or dirty members of the invention may be disassembled, cleaned or replaced.Type: ApplicationFiled: August 2, 2010Publication date: June 9, 2011Inventor: James Tang
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Patent number: 7942846Abstract: A needleless syringe having a membrane (28) which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.Type: GrantFiled: August 31, 2007Date of Patent: May 17, 2011Assignee: Powderject Research LimitedInventors: Brian John Bellhouse, David F. Sarphie, John Christopher Greenford
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Patent number: 7942845Abstract: Needle-free injection devices having a drive assembly to provide an operative force to effect an injection and a dosing assembly to prepare the device for a subsequent injection. In some embodiments, the dosing assembly is configured to transfer injectate from an injectate source to the injectate assembly. In some embodiments, a portion of energy available to the drive assembly urges the injectate towards the injectate assembly. In some embodiments, the device includes a nozzle assembly having one or more ports.Type: GrantFiled: June 19, 2007Date of Patent: May 17, 2011Assignee: Bioject, Inc.Inventors: Daniel E. Williamson, Ryan R. Beylund, Keith K. Daellenbach
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Patent number: 7931614Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.Type: GrantFiled: November 30, 2001Date of Patent: April 26, 2011Assignee: Valeritas, Inc.Inventors: Robert R. Gonnelli, David Lipson, Vasu Nishtala, Ciro Dimeglio
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Publication number: 20110046600Abstract: Described are devices useful to inject fluid to tissue without the use of a needle, and related methods; the devices include one or a combination of features such as ejection orifices, distal end control features, or combinations of these; the systems can include a fluid delivery system having an injector source and an access device; the access device can comprise a minimally invasive, tubular delivery lumen such as a catheter or endoscope; the tube-like device further includes one or more apposing jets that are selectively fired to force the injection orifice of the tube-like device against the target tissue; selective firing can include a continuous firing during the injection to improve the efficiency of the treatment.Type: ApplicationFiled: July 20, 2010Publication date: February 24, 2011Inventor: Justin M. Crank
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Publication number: 20110021980Abstract: The present invention relates to needle-free delivery devices for administering therapeutic or diagnostic therapeutic proteins that are based on single domain antibodies, and methods of using such a device in therapies or diagnostic applications.Type: ApplicationFiled: August 26, 2008Publication date: January 27, 2011Applicant: Ablynx N.V.Inventors: Torsten Dreier, Linda B. Hakes
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Publication number: 20110015567Abstract: A programmable injection device, comprising: a nozzle comprising a nozzle head with a fluid input hole and a distinct injection hole, the nozzle head accepts a dose of fluid from the fluid input hole to be injected into the skin of a patient through the injection hole, without use of a needle, a fluid capsule that is connected to said nozzle head and is adapted to provide the nozzle head with multiple doses of fluid for successive injections, without replacing the fluid capsule, an injection head that is adapted to have said fluid capsule and said nozzle head mounted onto it, comprising a first mechanism adapted to forcefully push a dose of a programmable amount of fluid from said fluid capsule to said nozzle head and a second mechanism for injecting by an programmable pressure said dose of fluid from said nozzle head into the skin of a patient in at least one of a programmable velocity or a programmable pressure applied to the skin surface.Type: ApplicationFiled: September 27, 2010Publication date: January 20, 2011Applicant: Perf-Action Technologies Ltd.Inventors: Zion AZAR, Eyal Baror, Amikam Gershonovitz, Pini Shalev, Gad Lev Konya, Yigal Ringart
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Patent number: 7854720Abstract: A needle-free injection device in which a gas cartridge or other source of pressurized gas is used to advance a piston and forcibly expel injectable fluid out through an injection orifice. When a gas cartridge is used, the gas cartridge may be moveable from an initial position to an actuating position in which gas is released to drive the injection, and a recoil inhibitor may be employed to prevent the gas cartridge from moving back to the initial position. A gas cartridge seal may be disposed on the gas cartridge and moveable with the gas cartridge to seal the gas cartridge against an interior wall of a gas cartridge housing. The needle-free injection device may also be configured so that sealing is compromised upon full advancement of the piston, so as to de-pressurize the device after delivery of an injection.Type: GrantFiled: November 23, 2009Date of Patent: December 21, 2010Assignee: Bioject, Inc.Inventors: Ryan R. Beylund, Keith K. Daellenbach
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Publication number: 20100312221Abstract: In order to provide a wearable drug delivery device for long term administration of drugs not employing a needle or canula, it is suggested according to the present invention that a wearable drug delivery device comprises a tubular reservoir (1) having an outlet end from which a drug may be expelled and a second end, a high-speed jet pump (2) for transdermal, needle-less micro-jet drug delivery, being connected to the outlet end of the tubular reservoir, a venting valve, being connected to the second end of the reservoir.Type: ApplicationFiled: May 20, 2008Publication date: December 9, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Giovanni Nisato, Jan-Eric Jack Martijn Rubingh
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Patent number: 7823584Abstract: An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.Type: GrantFiled: August 24, 2006Date of Patent: November 2, 2010Assignee: Boehringer Ingelheim International GmbHInventors: Johannes Geser, Burkhard P. Metzger, Christian Goldberg, Michael Schyra, Ralf Thoemmes, Birgit Westmeier, Guido Schmiedel, Hubert Kunze, Georg Boeck
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Patent number: 7803129Abstract: Described are a method and device for needleless injection of a liquid substance in the skin or other target tissue of a patient, in which droplets of the liquid substance are produced, and the droplets of liquid substance are directed toward the surface of the patient's skin or other target tissue at a velocity sufficiently high to inject the droplets of liquid substance in the patient's skin or other target tissue. The droplets of the liquid substance are accelerated toward the surface of the patient's skin or other target tissue in order to inject the accelerated droplets of liquid substance in the patient's skin or other target tissue.Type: GrantFiled: April 4, 2003Date of Patent: September 28, 2010Assignee: Societe de Commercialisation des Produits de la Recherche Appliquee-Socpra Sciences et Genie, S.E.C.Inventors: Martin Brouillette, Stephane Dufresne
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Patent number: 7790257Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.Type: GrantFiled: December 18, 2007Date of Patent: September 7, 2010Inventors: Andrew Skigen, Art Mofino, Craig Kroeger
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Publication number: 20100217122Abstract: A slip ring assembly for an injector is provided, where the injector includes a handle assembly coupled to a syringe barrel, and a plunger configured to rotate and slidably translate through a receptacle. The slip ring assembly includes a rotatable element disposed about the syringe barrel and configured to rotate at least partially about a circumference of the barrel, a retention groove positioned upon the syringe barrel, and a locking element including a protrusion complimentary with the retention groove and configured to engage retention groove and maintain rotatable element upon the syringe barrel.Type: ApplicationFiled: April 23, 2008Publication date: August 26, 2010Inventors: Hideo Fumiyama, Shawn P. Fojtik
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Publication number: 20100179473Abstract: A hypodermic drug delivery apparatus (10) for delivering a pressurized medication fluid (23) comprising a reservoir (14) containing at least one deliverable fluid (23) and a rupturing member (25) the reservoir (14) having at least one portion of at least one wall (22) rupturable by the rupturing member (25).Type: ApplicationFiled: December 27, 2007Publication date: July 15, 2010Inventor: Amir Genosar
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Publication number: 20100094196Abstract: The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal.Type: ApplicationFiled: September 25, 2009Publication date: April 15, 2010Inventors: John E. Nash, Douglas G. Evans, David M. Hoganson
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Publication number: 20100069831Abstract: A needle-free injection device in which a gas cartridge or other source of pressurized gas is used to advance a piston and forcibly expel injectable fluid out through an injection orifice. When a gas cartridge is used, the gas cartridge may be moveable from an initial position to an actuating position in which gas is released to drive the injection, and a recoil inhibitor may be employed to prevent the gas cartridge from moving back to the initial position. A gas cartridge seal may be disposed on the gas cartridge and moveable with the gas cartridge to seal the gas cartridge against an interior wall of a gas cartridge housing. The needle-free injection device may also be configured so that sealing is compromised upon full advancement of the piston, so as to de-pressurize the device after delivery of an injection.Type: ApplicationFiled: November 23, 2009Publication date: March 18, 2010Applicant: BIOJECT INC.Inventors: Ryan R. Beylund, Keith K. Daellenbach
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Publication number: 20100004621Abstract: The present invention provides a needle-free injector for delivering a medicament under pressure into an animal or human, the injector having a charging mechanism comprising a threaded shaft/nut member combination. The injection device is of the type that includes an actuating device comprising: a gas tight chamber; a piston and rod assembly slidably received in the chamber and movable between a forward position and a rearward position; a gas charge in the chamber for urging the piston and rod assembly to the forward position; a mechanism for moving said piston and rod assembly against said gas charge into the rearward position; and a trigger for releasably retaining the piston and rod assembly in the rearward position. Also provided is a method and kit for using the device including the charging mechanism to administer a liquid through the skin of an animal or human.Type: ApplicationFiled: June 7, 2007Publication date: January 7, 2010Applicant: AcuShot Inc.Inventors: Warren L. Toles, Kevin Toles, Jules Poiron
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Patent number: 7637889Abstract: Drug delivery devices adapted to receive liquid medication vials to fill a reservoir, utilize sliding through valves that are closed except when driven by force of liquid medication pushed by a plunger to an open position to feed the medication via needle to a patient or via a connection to an IV port. The devices have multiple seals and automatically close up when pressure on the plunger is released. The methodology is also included.Type: GrantFiled: November 15, 2006Date of Patent: December 29, 2009Assignee: GlynnTech, Inc.Inventor: Kenneth P. Glynn
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Patent number: 7618394Abstract: A needleless syringe having a membrane (28) which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.Type: GrantFiled: December 9, 2002Date of Patent: November 17, 2009Assignee: Powderject Research LimitedInventors: Brian J. Bellhouse, David F. Sarphie, John C. Greenford
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Publication number: 20090247940Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.Type: ApplicationFiled: June 8, 2009Publication date: October 1, 2009Applicant: BIOJECT, INC.Inventors: Daniel E. Williamson, Ryan R. Beylund
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Publication number: 20090240230Abstract: A needle-less fluid injection device, including, a nozzle head with an injection hole for accepting a dose of fluid to be injected into the skin of a patient, a fluid capsule that is connected to said nozzle head and provides the nozzle head with one or more doses of fluid for injection, an injection head for mounting the fluid capsule and the nozzle head; including a first mechanism for releasing a dose of fluid from the fluid capsule to the nozzle and a second mechanism for injecting the dose of fluid from the nozzle into the skin of a patient.Type: ApplicationFiled: June 28, 2007Publication date: September 24, 2009Applicant: PERF-ACTION TECHNOLOGIES LTD.Inventors: Zion Azar, Eyal Baror, Amikam Gershonovitz, Pini Shalev, God Lev Konya, Yigal Ringart
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Publication number: 20090234276Abstract: The present invention provides a needle-free injection device for delivering a medicament under pressure into an animal or human. The injection device includes an actuating device comprising: a gas tight chamber; a piston and rod assembly slidably received in the chamber and movable between a forward position and a rearward position; a gas charge in the chamber for urging the piston and rod assembly to the forward position; means for moving said piston and rod assembly against said gas charge into the rearward position; and a trigger for releasably retaining the piston and assembly in the rearward position. Also provided is a method and kit for using the device to administer a liquid through the skin of an animal or human.Type: ApplicationFiled: December 1, 2005Publication date: September 17, 2009Inventors: Warren L. Toles, Kevin Toles, Jules Poiron
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Patent number: 7547300Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.Type: GrantFiled: May 1, 2006Date of Patent: June 16, 2009Assignee: ICU Medical, Inc.Inventor: Thomas F. Fangrow
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Patent number: 7547293Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.Type: GrantFiled: October 6, 2006Date of Patent: June 16, 2009Assignee: Bioject, Inc.Inventors: Daniel E. Williamson, Ryan R. Beylund
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Publication number: 20090137949Abstract: A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.Type: ApplicationFiled: November 26, 2007Publication date: May 28, 2009Applicant: Bioject Inc.Inventors: Sergio Landau, Daniel E Williamson, John R. Marshall
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Publication number: 20090105685Abstract: A jet injection device comprises a medical jet unit (10), a medical drug dispensing unit (20) and an medical drug injection unit (30). The empty medical jet unit (10) is connected to the medical drug dispensing unit (20) and the plunger (11) inside the medical jet unit (10) snaps to the removable drug container (40) inside the medical drug dispensing unit (20), thereby creating fluid connection between the drug container (40) and chamber of the medical jet unit (10) via a hollow back needle.Type: ApplicationFiled: April 20, 2007Publication date: April 23, 2009Applicant: Novo Nordisk A/SInventors: Torben Stroem Hansen, Carsten Soerensen
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Publication number: 20090099510Abstract: A sealing membrane 20 on a nozzle 10 for a jet injection device is adapted to seal off the nozzle orifice 12 by having a sealing rim 22 surrounding the nozzle orifice 12, which ensures a distinct closure of the nozzle orifice 12 to protect the nozzle geometry against damage and dirt and to protect the drug 30 contained in the cartridge 10 against contamination. The sealing rim 22 can narrowly enclose the nozzle orifice 12, or in case an adhesive 14 is applied to the nozzle face to ensure skin retention during injection, the sealing rim 22 can run in the middle of the adhesive covered area or entirely outside the adhesive covered area to protect the adhesive as well. A third sealing member 23 can also be provided to give a third distinct closure assurance in case the primary and secondary sealing membrane 20 is damaged. The third sealing member 23 can be one or more plug(s) adapted to press fit inside the nozzle orifice.Type: ApplicationFiled: January 19, 2007Publication date: April 16, 2009Applicant: Novo Nordisk A/SInventor: Jens Ulrik Poulsen
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Patent number: 7510548Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.Type: GrantFiled: May 2, 2006Date of Patent: March 31, 2009Assignee: ICU Medical, Inc.Inventor: Thomas F. Fangrow
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Patent number: 7449009Abstract: An injection channel is produced in human or animal tissue by means of a pre-injection device for incorporating a medium which is to be injected. Said pre-injection device comprises a chamber which is used to receive a pre-injection medium, a nozzle which is provided for attachment to the skin and a pressure generating device which acts on the chamber in order to generate a high-pressure jet from the pre-injection medium exiting from the nozzle. Said type of needle-free pre-injection device is serially connected to a main injection device.Type: GrantFiled: June 13, 2003Date of Patent: November 11, 2008Assignee: primoJEX GmbHInventor: Peter Eichhorst
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Publication number: 20080119784Abstract: A needleless fluid delivery system for delivering therapeutic fluids to treatment sites within a patient. The fluid delivery system can include an automated injector source and a needleless access device. The access device can include a delivery scope and a treatment specific applicator. The automated injector source, delivery scope and applicator can be operably coupled with quick-connect style fittings so as to allow for quick replacement and maintenance of used or damaged components. The automated injector source can include a hands-free input mechanism allowing a medical professional to use both hands in manipulating the delivery scope and needleless applicator at the same time an injection is desired. The delivery scope and needleless applicator can comprise flexible or rigid lengths of tubing based on the accessibility of the treatment site. The needleless delivery system can include an imaging system for precisely position the applicator with respect to the treatment location.Type: ApplicationFiled: November 19, 2007Publication date: May 22, 2008Inventors: Suranjan Roychowdhury, Vincent G. Copa, Sidney F. Hauschild
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Publication number: 20080114203Abstract: An endoscope adapter ring for a needleless fluid delivery system for delivering therapeutic fluids to treatment sites within a patient. The needless fluid delivery system can include an automated injector source and a needleless access device. The access device can include a delivery scope and a treatment specific applicator. The adapter ring is operably attached to the endoscope to keep the injector lumen in a known orientation for the use of a side injector.Type: ApplicationFiled: November 9, 2007Publication date: May 15, 2008Inventor: Justin M. Crank
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Patent number: 7357781Abstract: A needleless injector includes a barrel for receiving an injectable liquid, a nozzle closing one end of the barrel containing an injection orifice, and a plunger and piston combination in the barrel. A valve admits gas under pressure into the barrel behind the piston. A trigger opens the valve to cause the piston to move against the plunger, and a magnet retains the piston in a rest position in the barrel until acted upon by the gas under sufficient pressure to cause the piston and plunger to move to an extended, discharge position.Type: GrantFiled: January 22, 2003Date of Patent: April 15, 2008Inventor: Karim Menassa
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Publication number: 20080086079Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.Type: ApplicationFiled: October 6, 2006Publication date: April 10, 2008Applicant: BIOJECT, INC.Inventors: Daniel E. Williamson, Ryan R. Beylund
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Patent number: 7354427Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.Type: GrantFiled: June 21, 2006Date of Patent: April 8, 2008Assignee: ICU Medical, Inc.Inventor: Thomas F. Fangrow
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Patent number: 7347851Abstract: In the present invention, the impedance between patient's body and the jet injection drug delivery device is measured through the liquid jet during the drug delivery process. The liquid jet completes the electrical circuit formed by impedance monitor, drug delivery device, and the patient's body. When the jet pierces stratum corneum, the impedance in the circuit immediately decreases, thus an indicating the successful drug delivery. The impedance monitor then provides a signal, visible, audible, or electronic, indicating that the process of the drug delivery through skin was successful.Type: GrantFiled: March 9, 2004Date of Patent: March 25, 2008Inventor: Leo B Kriksunov
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Patent number: 7238167Abstract: A needle-free injection device is described. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.Type: GrantFiled: January 13, 2004Date of Patent: July 3, 2007Assignee: Bioject Inc.Inventors: Sergio Landau, Daniel E. Williamson, John R. Marshall
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Patent number: 7207967Abstract: A needleless syringe particle delivery system is provided. The needleless syringe has an elongate nozzle that is connected at its upstream end to a sealed chamber. The sealed chamber contains gas at super-atmospheric pressure and particles of a therapeutic agent. Upon release of the gas from the sealed chamber, a flow is formed which entrains the particles and allows the particles to pass through the nozzle at supersonic speed for subsequent delivery to a target surface.Type: GrantFiled: February 13, 1997Date of Patent: April 24, 2007Assignee: PowderJect Research LimitedInventors: Brian John Bellhouse, Paul Rudd Drayson, John Christopher Greenford, Charles David Ogilvy Potter, David Francis Sarphie
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Patent number: 7195610Abstract: A pneumatic syringe driver having a control module for regulating pressure applied to the plunger of an associated syringe is disclosed. The syringe driver is adapted for receiving a compressed gas canister and for enabling the selective release of gas from the canister into a chamber, one wall of which being formed by the syringe plunger via a three-way valve. The valve also enables the selective venting of gas from the canister into the atmosphere, thereby forming a venturi which reduces the pressure in the chamber and causes the syringe plunger to be withdrawn into the chamber. A pressure sensor in communication with the control module is provided for pressure feedback. Pushbuttons or switches in communication with the control module are provided for defining the syringe driver operation. The device is suited for the selective inflation and deflation of a balloon attached to the syringe driver for a balloon angioplasty procedures.Type: GrantFiled: September 17, 2002Date of Patent: March 27, 2007Assignee: Cardinal Health 303, Inc.Inventor: Eric J. Flachbart
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Patent number: 7182748Abstract: A syringe, for use in the delivery of a dose of a therapeutic agent entrained within a pressurized fluid flow, includes an upstream portion, an intermediate portion, a downstream portion, and an actuator mechanism for initiating a flow of the fluid through the syringe. The upstream portion is interfaced with a source of fluid under pressure. The intermediate portion, which is interposed between the upstream and downstream portions, includes first and second members that are coupled together to provide a closed pocket for containing the dose. One of the first and second members is moveable relative to the other within the syringe to provide an open configuration in which the pocket is opened to expose the dose for entrainment by the fluid as it flows through the intermediate portion and to and through the nozzle. Also provided is a capsule formed from the first and second members.Type: GrantFiled: July 6, 1998Date of Patent: February 27, 2007Assignee: PowderJect Research LimitedInventors: Charles Potter, David Stuart Potter, Brian Bellhouse, John Christopher Greenford, Fiona Carter, Stuart Graham Weekes, Colin Sheldrake
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Patent number: 7156823Abstract: A needle-free injection device is described. The injection device typically includes a system for providing directed and pre-selected pressure and a nozzle with an orifice for defining a stream of fluid that is directed toward the skin of a patient against which a front end of the nozzle is positioned. The device also normally includes an engagement system that can selectively engage the nozzle with the pressurizing system so that the nozzle can be mounted to the pressurizing system to receive pressure for injection and so that after injection the nozzle can be removed and replaced for each new use of the device.Type: GrantFiled: June 9, 2003Date of Patent: January 2, 2007Assignee: Bioject Inc.Inventors: Sergio Landau, Daniel E. Williamson
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Patent number: 7156822Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurised for injection.Type: GrantFiled: May 20, 2004Date of Patent: January 2, 2007Assignee: CrossjectInventors: Alain Navelier, Patrick Alexandre, Bernard Brouquieres, Philippe Gautier
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Patent number: 7150409Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection device comprising: an injector defining a first cavity and an orifice; a movable member in the first cavity; a housing defining a second cavity proximal of the movable member; and a charge in the second cavity, the charge comprising at least two discrete materials.Type: GrantFiled: November 30, 2001Date of Patent: December 19, 2006Assignee: BioValve Technologies, Inc.Inventors: Robert R. Gonnelli, David Lipson, Vasu Nishtala, Ciro Dimeglio
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Patent number: 7074210Abstract: Disclosed is a medical device used to prevent the cross-contamination of patients or injectors in which various components placed on the injector minimize or eliminate back splash contamination of the injector.Type: GrantFiled: October 11, 2002Date of Patent: July 11, 2006Assignee: Felton International, Inc.Inventors: Nathaniel J. Leon, Victor T. Rogatchev, Michael Mathews
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Patent number: 7060048Abstract: A needleless syringe device for accelerating particles into a target tissue of a vertebrate subject is provided. The syringe features an elongate, tubular duct having a lumen for delivering the particles towards the target tissue. The duct may have a constant cross-sectional area. The device further features a receptacle holding the particles and a gas discharge chamber upstream of the receptacle. On actuation the gas discharge chamber discharges pressurised gas having a maximum total pressure of about 10 bar or less. Methods of using the device for delivering particles to a target tissue are also provided.Type: GrantFiled: April 14, 2000Date of Patent: June 13, 2006Assignee: PowerJect Research LimitedInventors: Avtar S. Nat, Stuart P. Hendry, Colin Sheldrake
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Patent number: 7056300Abstract: A needleless syringe comprises a reservoir sealed with mobile closure elements enclosed the liquid, the reservoir being initially isolated from the injection system which is so designed that it comprises at least two peripheral injection conduits located outside a receptacle comprising a blind bore which receives the downstream closure element such that the inlets of the conduits are cleared.Type: GrantFiled: January 26, 2001Date of Patent: June 6, 2006Assignee: CrossjectInventors: Patrick Alexandre, Bernard Brouquieres, Xavière Castano, Philippe Gautier
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Patent number: 6994127Abstract: An injection device having a propulsion system comprises a container, a re-usable pressure generating mechanism and a source of potential energy for propelling a fluid with sufficient pressure through an orifice to create a jet enabling subcutaneous or intracutaneous delivery of the fluid, the source of potential energy primarily in the form of a compressible substance that is put under pressure within the container by the pressure generating mechanism, whereby said potential energy is substantially compression energy of said substance, wherein said substance is liquid, solid, or other non-gaseous substance as defined at ambient temperature and said pressure.Type: GrantFiled: June 20, 2003Date of Patent: February 7, 2006Assignee: Tecpharma Licensing AGInventor: Arnold Neracher
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Patent number: 6986754Abstract: A needleless hypodermic injection system for injecting a liquid medication, which system comprises a disposable cartridge which contains a medication and which includes a propellant and an igniter, and a reusable application device which comprises a pressure chamber for receiving the medication cartridge, actuation means including an ignition system and means for ensuring reliability and safety of the system. The reusable application device comprises: (a) a housing including a fist housing section and a second housing section which are adapted to be assembled together by a screwing operation, the first housing section comprising a front part having an injection outlet and a chamber adapted to receive a the cartridge contains the medication to be injected and also contains a propellant and an igniter, and (b) means for selectively activating said igniter of said cartridge when predetermined conditions are fulfilled.Type: GrantFiled: March 19, 2002Date of Patent: January 17, 2006Assignee: Roche Diagnostics GmbHInventors: Hans-Peter Haar, George Bevan Kirby Meacham, Konrad Joseph Popp, Otto Bruntrup, Ulrich Josef Riemensperger, Guenter Franz Ihle, Bruno Robert Thös, Hans List, Dirk Bandau, Horst Engelhardt, Christian Gliewe