Abstract: A device for administering an injectable product in doses including a dosage reservoir from which a product dosage is administered, a storage reservoir for storing the product, a transfer conveyor for conveying the product dosage from the storage reservoir into the dosage reservoir, an evacuator for evacuating the dosage reservoir, and a dosing and activating mechanism for performing a dosing movement for selecting the product dosage, a conveying movement for activating the transfer conveyor and an evacuating movement for activating the evacuator.

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurized for injection.

Abstract: The technical field is that of pre-filled disposable needleless syringes, operating with a gas generator (100) and used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic purposes in human and veterinary medicine. The inventive needleless syringe (1) is characterised in that it comprises a compact architecture body (2) and the gas generator (100) is released by a cap (17) covering said body (2), said cap (17) being adapted to slide along said body (2). Said releasing mode provides the syringe with great stability (1) at the time of injection.

Abstract: Injection devices, such as needleless injection devices, and methods of making the using the same are disclosed.

Abstract: Method and surgical instrument for treating prostate tissue including a surgical instrument having a main body, a needle deployment port, a needle, first and second handles and a lockout release mechanism to limit needle extension. Additionally, a kit includes the surgical instrument, together with a cystoscope, and optionally a syringe and reservoir of ethanol. The method includes needle-less injection and visualizing the ethanol injection by delivering both an echogenic agent and ethanol either by needle or needle-less injection or by providing an ultrasonically visible marker near the tip of the ethanol delivery cannula. The method also includes extending the needle transversely of the instrument housing using a link assembly.

Abstract: Replaceable components for use with a needleless syringe delivery device are provided. One replaceable component is a cartridge having a source of particles and a source of compressed gas. Another replaceable component is a nozzle assembly having a particle acceleration nozzle and a coaxial filter element. Reusable needleless syringe devices which include these replaceable components are also provided.

Abstract: An active, transdermal delivery system includes a support structure and a fluid reservoir within the support structure configured to contain a fluid to be delivered transdermally. There is also at least one exit orifice defined in the support structure that is in communication with the fluid reservoir. The orifice has a diameter of between about 1 &mgr;m and 500 &mgr;m. Furthermore, a repeatable activation means is disposed within the support structure and is in cooperation with the exit orifice for ejection of fluid in response to an activation signal.

Abstract: Injection devices, such as needleless injection devices, and methods of making the using the same are disclosed.

Abstract: A pressurized aerosol dispenser comprising a container (2) for material to be stored therein and dispensed therefrom, and a metering dispensing valve (1), said metering dispensing valve (1) comprising a generally cup-shaped metering vessel (7) held in place by means of a cap (3) fixedly mounted upon said container (2), and a sealing member (9) disposed between the metering vessel (7) and the cap (3), said sealing member (9) having an opening within which a valve stem (8) is mounted for sliding movement along a longitudinal axis, the metering vessel (7) having an open mouth, an internal surface of which defines an annular contact surface (24, 25) against which said sealing member (9) bears, wherein said contact surface (24, 25) comprises a first outwardly-flared portion (24) disposed at a first angle to said longitudinal axis and a second outwardly-flared portion (25) disposed at a second angle to said longitudinal axis, said second angle being greater than said first angle such that an annular ridge (26) is f

Abstract: Disclosed and claimed is the use of a liquid jet intradermal administration apparatus that administers a composition: without a needle; and in the epidermis, dermis and/or hypodermis, such as a Pigjet apparatus, for administering bovine vaccines or immunogenic compositions, especially bovine plasmid vaccines or immunogenic compositions. Accordingly, the invention involves bovine immunogenic or vaccine compositions in such an apparatus, and methods for vaccinating bovines or for inducing an immunogenic response in bovines employing such an apparatus, as well as the apparatus containing bovine immunogenic or vaccine compositions.

Abstract: Disclosed is a medical device used to prevent the cross contamination of patients or injectors.

Abstract: A single use needleless hypodermic injection device for injecting a liquid medication contained therein. The device includes pyrotechnical means for generating within the device a pressure necessary for injecting the medication. The device comprises impact-sensitive stab primer ignition means for igniting a propellant contained in the device.

Abstract: A needleless injector system including: a first injector assembly; a gas capsule disposed within the first injector assembly and containing pressurized gas, with a pierceable surface at the forward end thereof to provide an injection source; a gas capsule piercing member disposed within the first injector assembly, where the piercing member and the gas capsule are movable relative to each other; a second injector assembly containing a medical treatment fluid and having a forward facing injection orifice for injecting the medical treatment fluid into a patient; and a resilient seal mounted between the gas capsule and the first injector assembly to contain all pressurized gas within a forward end of the first injector assembly after pressurized gas is released from the gas capsule following piercing of the gas capsule, in order to cause an immediate increase in pressure in the medical treatment fluid contained within the second injector assembly.

Abstract: A needleless syringe capable of accelerating particles comprising a therapeutic agent across skin or mucosal tissue of a vertebrate subject is provided. The syringe comprises a body having a lumen with a diaphragm located adjacent to a terminus thereof. Particles comprising a therapeutic agent are delivered from an external surface of the diaphragm by means of the motive force provided by the impact of a gaseous shock upon the internal surface of the diaphragm. A method for transdermally delivering particles comprising a therapeutic agent from the needleless syringe is also provided.

Abstract: A device for dispensing at least two mutually reactive components, such as fibrinogen and thrombin, comprising a supplier (12A, 12B) having a primary channel for supplying a respective one of said at least two reactive components to a dispenser (14) having secondary channels (18A, 18B) for separately discharging said components at a distal end orifice thereof opening into a target area for external intimate mixing of the respective reactive components outside a distal tip end of said dispenser (14). A distributor (38, 40) is interposed between said supplier and said dispenser for multiplying the number of the respective primary channels with at least a factor 2. Adjacent ones of said secondary channels (18A, 18B) are adjoined to primary channels (32, 34) intended for supply of reactive components of different kind.

Abstract: A gas-powered, durable, needle-less hypodermic jet injection device (10, 210) includes a hand-held injector (12, 212) which receives into an injection cylinder a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its usability, particularly for users with hands that are possibly weak, feeble, or arthritic, for example; and also includes additional features which improve manufacturability, durability, and cost effectiveness of the device.

Abstract: A system for injecting DNA-based medications into humans is provided by the present invention. The system includes a needle-free injector with an injection orifice of approximately 0.004 inches for supplying DNA-based medication at an initial pressure of from 3900 to 4300 psi, and then immediately declining to a level of about 2800 to 3800 psi, and then immediately cutting off pressure to terminate the injection. The injector includes an annular adapter for spacing the injection orifice from the skin of the patient. The adapter includes an abutment against which the injector is disposed so that the orifice is spaced approximately 0.76-1.0 inch from the skin of the patient, the adapter having an inner diameter at the distal end of approximately 0.50-0.70 inches.

Abstract: A jet-injector device comprising a) a housing, b) a pressure chamber for a liquid to be ejected attached to or enclosed in the housing, the pressure chamber having at least one opening and at least one movable or collapsible-wall or wall segment and c) a pressurizing mechanism attached to or enclosed in the housing operable to apply, directly or indirectly, force in a force chain between the housing and the wall to pressurize the pressure chamber content for ejection of a liquid jet through said opening, the mechanism comprising at least a force generator and optionally a transmission between the force generator and the wall. The device comprises an in elastic element serially arranged between the force generator and the wall.

Abstract: The present invention relates to a system for delivering and injecting an agent into a target site within the body without penetrating the tissue of the target site with anything other than the agent. The system comprises a nozzle assembly and a propulsion mechanism. The nozzle assembly comprises an ampule with a reservoir, having a reservoir orifice, for containing the agent; a dispersion fixture that has a dispersion orifice; and a channel in fluid communication between the reservoir orifice and the dispersion orifice. The propulsion mechanism is operatively coupled to the reservoir for propelling the agent from within the reservoir, through the reservoir orifice and the channel and the dispersion orifice, at a pressure sufficient to cause the agent to penetrate the target site without penetration of the target site with the dispersion fixture. Methods of using and making the system are also disclosed.

Abstract: An injector device for delivery of liquid from a high pressure, the device comprising a housing, a pressure chamber 2 comprising a pressure barrel 4 for accommodation of at least one piston therein and having a front end opening 6 for ejection of the liquid, the pressure chamber being of sufficient strength to sustain the liquid pressure. The device further comprises a storage chamber 16, separate from the pressure chamber, for the liquid or the liquid precursor components, and a conduit 22 between the pressure chamber and the storage chamber. A pressurizing mechanism 26 in the housing is arranged to apply force, directly or indirectly, on the piston in the pressure barrel to create said liquid pressure.

Abstract: The present invention relates to methods and compositions for the needleless administration of permanent makeup and tattoos. In particular, the present invention relates to hypodermic injectors for use in delivering pigment or other desired substances to targeted layers of the skin, avoiding needlestick injuries and transmission of disease to the treated subject.

Abstract: A needleless syringe comprising a body containing a lumen, an upstream end of which is, or is arranged to be, connected to a source of gaseous pressure which can suddenly be released into the lumen; the downstream end of the lumen terminating behind a bistable diaphragm which is movable between an inverted position in which it presents outwardly of the body a concavity for containing particles of a therapeutic agent, and an everted, outwardly convex, position; the arrangement being such that, in use, when gas under pressure is released into the lumen, the diaphragm will snap over from its inverted to its everted position and catapult the particles outwardly.

Abstract: A jet injector having cartridge and power pack assemblies is disclosed. In one embodiment, the cartridge assembly includes a tube containing the medicament with a plunger at one end and a stopper at the other end. The plunger is movable within the tube lumen to force the stopper against a needle, thereby creating a fluid pathway through the stopper. In another embodiment, only the plunger is movable within the tube lumen and the stopper, which can be integral to the rest of the cartridge assembly or a separate component, already has a pathway for ejection of the medicament. The present invention also relates to an energy mechanism for the power pack assembly that is a gas spring containing a charging material existing in liquid and gaseous phase equilibrium within the gas spring to maintain a substantially constant pressure prior to activation.

Abstract: A needle-free injection device. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Abstract: A needle-free injection device. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Abstract: A gas-powered, durable, needle-less hypodermic jet injection device (10, 110) includes a hand-held injector (12, 112) which provides a volume of liquid medication to be injected, an injection orifice, and an injection piston. Forceful movement of the injection piston causes an injection jet of medication to be expelled from the injection orifice. The injection device also includes a hermetically sealed gas pressure cartridge (28) which is opened in preparation to effecting a jet injection, and which powers the jet injection, but from which pressurized gas is not allowed to flow in volume until a user of the device shifts a valving spool (24).

Abstract: A method for injecting a fluid medicament into a patient uses a syringe having a plunger that can be advanced into the syringe chamber. As the plunger is advanced, the medicament is expelled from the chamber through an injection tube that extends from the chamber. Preferably, the injection tube is formed as a cone-shaped funnel with a taper of generally decreasing radius in a distal direction. The steps for the method include creating a gas pocket in the distal portion of the injection tube. Then, as the plunger is advanced into the chamber to accelerate the fluid medicament through the injection tube, the gas pocket allows the accelerating fluid medicament to gain momentum. The change in this momentum as the fluid medicament collides with the skin will generate an impulse force that is manifested as an initial pressure spike. This pressure spike creates a hole in the skin of the patient as the fluid medicament exits the tube.

Abstract: Disclosed is medical device, such as a mass injector, that has a protective cap disposed on it that minimizes or eliminates cross contamination, wherein the cap can be ejected in a quick manner.

Abstract: The invention concerns the technical field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle (7, 70) initially set between an injector (1, 10) comprising at least an injection nozzle (50, 50′, 60′) contacted with the skin and a wall (8) mobile under the effect of a propelling system (9) pressurizing and expelling the active principle through the injector located at the downstream end (2, 20) of the syringe. In order to produce nozzles passing through a considerable injector thickness and to control the jet coherence distance, said injector (1, 10) comprises a support (3, 21) with at least a housing (4, 40) wherein are stacked plates (51, 61, 91, 51′, 71′, 91′, 52, 92) each comprising an equal number of orifices aligned to form at least a nozzle (50, 50′, 60′) through the stack.

Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve.

Abstract: Injection systems and devices that can be used in injection systems are disclosed.

Abstract: A gas-powered, durable, needle-free hypodermic jet injection device includes a hand-held injector which carries a disposable injection cartridge with a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston caused by high pressure gas causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its safety, and also which improve its ease of manufacture, its durability, and its cost effectiveness.

Abstract: In accordance with the current invention, a needle-free injection system includes a cap that has a first seal for sealing an injection orifice when the cap is engaged with an injection end of the system. The cap also includes a push-rod for facilitating priming of the system when engaged with a priming end of the system. The system also includes a push-rod engaging mechanism disposed at the priming end of the system for receiving the push-rod for priming the system. The system further includes a gas cylinder for supplying pressurized gas for injecting, via the injection orifice, an injectate initially disposed within a storage chamber, and a sealing system for preventing the pressurized gas from ejecting the injectate from the system prior to actuation of the system. Actuation of the system is achieved via a slidable trigger plate.

Abstract: The present invention relates to a jet injector system with a hand piece. The present invention generally comprises a power unit, a medicine unit, an energy unit, a supply bottle, and a hand piece. The hand piece and power unit may be separate components connected to each other by a high pressure hose, which gives the user more flexibility. A valve assembly having a ball lock assembly and a needle assembly controls the release of medication from the high pressure hose into the hand piece and out a nozzle into the subject.

Abstract: The automatic control-type, portable intravenous infusion apparatus includes an infusion liquid container to which an infusion liquid tube is connected, pressurize it, the infusion liquid tube being provided with a drip-monitoring tube, a connector and an infusion needle with a pressurizing bag for holding the infusion liquid container. The infusion liquid container includes an inflatable pressurizing bag and a sheet member having side ends each fixed to the side ends of the pressurizing bag. Connected to the pressurizing bag are an air tube provided with a mechanical safety valve, a selector valve and an air pump. By introducing air into the infusion liquid container, the pressurizing bag is inflated to apply substantially a constant pressure to the infusion liquid container, thereby flowing the infusion liquid from the container and keeping the dropping speed there substantially constant.

Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the liquid from the housing at a speed sufficient to pierce an injection surface. In one embodiment, the needle-less injector includes a mechanism for mitigating the kickback associated with releasing compressed gas from the engine. In another embodiment, the housing includes finger rests that provide stability and resistance to activate the device. In another embodiment, the engine is fitted with a reusable valve. In another embodiment, a safety clamp is included on the housing, preventing accidental activation of the device.

Abstract: The technical field of the invention is that of needleless syringes used for injecting active principles in powder form for therapeutic purposes. The invention concerns a needleless syringe (1) comprising successively a gas generator (2), a gas expanding chamber (3), means for retaining active particles and an ejection tube (4). The invention is characterised in that the particle retaining means consists of an inner seal (14) having at least a cavity (15), the inner seal (14) serves both to contain the active principle and to generate a shock wave when it is ruptured.

Abstract: A needle-less injector suitable for injecting fluid through a surface includes a housing, a driver, an engine and a trigger. The housing contains a fluid and the engine contains a compressed gas. Upon application of sufficient force to the trigger, the compressed gas is released from the engine forcing the driver through the interior of the housing, expelling the fluid from the housing at a speed sufficient to pierce an injection surface. An aerodynamic diffuser maximizes air flow to the driver, allowing greater injection speed and mitigating pain associated with receiving an injection. Use of the injector is both silent and easy to activate, owing to an O-ring included about the circumference of the exterior of a diffuser operating within the engine. Further, the engine has safety features preventing a portion thereof from separating from the device under elevated temperatures and similar conditions. Engine leakage is obviated by the inclusion of a leakage ring therein.

Abstract: A gas-powered, durable, needle-less hypodermic jet injection device (10, 110) includes a hand-held injector (12, 112) which provides a volume of liquid medication to be injected, an injection orifice, and an injection piston. Forceful movement of the injection piston causes an injection jet of medication to be expelled from the injection orifice. The injection device also includes a hermetically sealed gas pressure cartridge (28) which is opened in preparation to effecting a jet injection, and which powers the jet injection, but from which pressurized gas is not allowed to flow in volume until a user of the device shifts a valving spool (24).

Abstract: A gas-powered, durable, needle-free hypodermic jet injection device includes a hand-held injector which carries a disposable injection cartridge with a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston caused by high pressure gas causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its safety, and also which improve its ease of manufacture, its durability, and its cost effectiveness.

Abstract: A gas-powered, durable, needle-less hypodermic jet injection device (10, 210) includes a hand-held injector (12, 212) which receives into an injection cylinder a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its usability, particularly for users with hands that are possibly weak, feeble, or arthritic, for example; and also includes additional features which improve manufacturability, durability, and cost effectiveness of the device.

Abstract: A needleless hypodermic injection system for injecting a liquid medication, which system comprises a disposable cartridge which contains a medication and which includes a propellant and an igniter, and a reusable application device which comprises a pressure chamber for receiving the medication cartridge, actuation means including an ignition system and means for ensuring reliability and safety of the system.

Abstract: A needleless drug particle delivery device, of the kind in which firing of the drug particles is caused by a sudden gas flow, characterised in that the device comprises a container (14) of compressed gas and a mechanism for releasing the gas from the container to create the gas flow, the mechanism comprising a rupture (20) element for breaching the container and a manually manipulable actuator (27) for moving the element and the container relatively to one another to provide an initial breach whereby gas is released to act on a piston portion (21) to provide a servo action which causes the rupture element and container to move further suddenly relatively to one another to complete the breaching of the container and establish a maximum gas flow from the container.

Abstract: Injection systems and devices that can be used in injection systems are disclosed.

Abstract: Disclosed and claimed is the use of a liquid jet intradermal administration apparatus that administers a composition: without a needle; and in the epidermis, dermis and/or hypodermis, such as a Pigjet apparatus, for administering bovine vaccines or immunogenic compositions, especially bovine plasmid vaccines or immunogenic compositions. Accordingly, the invention involves bovine immunogenic or vaccine compositions in such an apparatus, and methods for vaccinating bovines or for inducing an immunogenic response in bovines employing such an apparatus, as well as the apparatus containing bovine immunogenic or vaccine compositions.

Abstract: One form of the invention provides a needle-free injection system including the following components: a nozzle portion having a glass wall defining a drug storage space, and an injection wall defining a drug injection space, the injection wall being coaxial with the glass wall and defining a plurality of drug bypass conduits disposed adjacent a forward end of the drug injection space; an injection orifice defined at the forward end of the injection space; a drug plunger defining a rearward end of the storage space; a drug plug initially disposed between the storage space and the injection space, and being displaceable into the injection space adjacent the bypass conduits; and a pierceable gas cartridge for providing injection power to the drug plunger.

Abstract: One form of the present invention provides a needle-free injection system including the following components: a cartridge for holding liquid drug prior to injection, the cartridge having a rear end and a front end; a plug mounted to the front end of the cartridge, the plug including a channel; a displaceable valve positioned within the channel prior to injection; and a nozzle portion for receiving liquid drug from the glass cartridge for injection, the nozzle portion including an injection orifice and a drug chamber having a valve seat designed to receive the valve to facilitate injection of liquid drug through the injection orifice.

Abstract: The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.

Abstract: An ejection device for ejecting a liquid or a liquid containing solid particles at high pressure, comprising a head unit; a pressure chamber (11) which opens into a distal ejection opening and is delimited by a working piston which, upon application of an elastic impact on its end facing away from the pressure chamber, is capable of transmitting a compression wave which may displace the pressure chamber-facing end of the working piston into the pressure chamber so that the volume thereof is reduced, with the reduction in volume of the pressure chamber being significantly smaller than the original volume of the pressure chamber; and a drive unit having a drive member which is accelerated across an acceleration portion formed within the drive unit so that it generates the elastic impact to be transmitted to the working piston. The pressure chamber is at least partially formed by a pressure cavity formed in the head unit.

Abstract: A hypodermic needleless injection system for injecting a liquid medication, which system comprises: a medication unit configured and dimensioned to store a volume of liquid to be injected, the medication unit having a first region and a second region that are in liquid communication with each other, the first region being deformable and the second region having at least one orifice, a hydrostatic chamber containing a hydrostatic pressure transfer medium, the hydrostatic chamber being so configured and dimensioned that the medication unit is located at least partially within the hydrostatic chamber and so that a pressure exerted on the transfer medium would cause the first region of the medication unit to deform so as to reduce the volume available for the liquid medication within the medication unit, and a first piston having a first end and a second end opposite to the first end, the first end having a surface which forms a closure of the hydrostatic chamber, and is adapted for applying a pressure on the tra