Solid Treating Material Patents (Class 604/84)
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Patent number: 6036669Abstract: An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a feeding set having an inlet and an outlet. The inlet is constructed for fluid connection to a supply container. The feeding set defines an interior space. The apparatus further includes a canister disposed in the interior space defined by the feeding set. The canister includes a wall portion that defines an aperture therethrough. The canister is constructed to receive one or more beneficial agents in an interior chamber defined therein. At least one beneficial agent disposed in the interior chamber defined by the canister.Type: GrantFiled: February 27, 1998Date of Patent: March 14, 2000Assignee: Abbott LaboratoriesInventors: Rhonda L. Cole, Ronita K. Geckle, John J. Kropczynski, Jr., Terrence B. Mazer, Joseph E. Walton, Daniel Zevchik
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Patent number: 5925015Abstract: A nutritional system is disclosed, for delivering a colorant dye to a nutritional fluid that flows through the nutritional system.Type: GrantFiled: May 20, 1997Date of Patent: July 20, 1999Assignee: ALZA CorporationInventors: Richard G. Weyers, Atul D. Ayer, Brenda J. Pollock, Brian L. Barclay, Ernest S. Quan
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Patent number: 5910321Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.Type: GrantFiled: October 14, 1997Date of Patent: June 8, 1999Assignee: Alza CorporationInventors: Patrick S.-L. Wong, Nathan Roth, Vincent J. Ferrari
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Patent number: 5817056Abstract: A prefilled syringe capable of separate storage of different substances before use. It includes a tubular body having an injection needle at one end and a plunger at the other end, and a partition slidable axially in the tubular body. The partition includes a front part and a rear part independent of each other, and as a whole dividing the interior space of the tubular body into a front compartment and a rear compartment in a sealing manner for storing mutually different substances. A bypass is disposed generally between the front and rear compartments to introduce the substance in the rear compartment into the front compartment when the partition is slid under pressure provided by the plunger to be adjacent to the bypass to thereby mix the substances immediately prior to injection.Type: GrantFiled: September 11, 1996Date of Patent: October 6, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Nobuo Tanaka, Jotaro Kishimoto, Kotaro Wakamatsu, Takayuki Hagihara, Seiji Ohtani
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Patent number: 5755689Abstract: An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof.Type: GrantFiled: June 28, 1996Date of Patent: May 26, 1998Assignee: Abbott LaboratoriesInventors: Terrence Bruce Mazer, Joseph Edward Walton, Ronita Kay Geckle, Carl Joseph Piontek, Susan Beth Duel, Andre Daab-Krzykowski, Robert Louis Joseph, William Guy Pierson, Thomas Daniel Loughrin, Thomas Walter Osip
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Patent number: 5755688Abstract: An apparatus and method are disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply to a feeding tube delivering the modified liquid enteral nutritional product to the gastrointestinal tract of a patient. At least one beneficial agent not in controlled release dosage form in a useful, dose unit, amount, is disposed within a formulation chamber so as to be taken up in a liquid enteral nutritional product traversing the formulation chamber while feeding the modified nutritional product into the gastrointestinal tract of a patient. The beneficial additive(s) are selected from nutrients, medicaments, probiotics, or diagnostic agents, or mixtures thereof, each in a dosage form that is dispersible in the medium of the liquid enteral nutritional product in less than two hours.Type: GrantFiled: July 1, 1996Date of Patent: May 26, 1998Assignee: Abbott LaboratoriesInventors: Carl Joseph Piontek, Terrence Bruce Mazer, Joseph Edward Walton, Bonita Kay Geckle
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Patent number: 5738651Abstract: An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added.Type: GrantFiled: June 28, 1996Date of Patent: April 14, 1998Assignee: Abbott LaboratoriesInventors: Joseph Edward Walton, Terrence Bruce Mazer, Ronita Kay Geckle, Carl Joseph Piontek, Susan Beth Duel, Andre Daab-Krzykowski, Mark Anthony McCamish, Robert Louis Joseph, William Guy Pierson
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Patent number: 5569192Abstract: An automatic injector for the separate storage of a solid and a solvent for this solid. The injector comprises a discharge mechanism, a cartridge assembly and a front cover which is connected to a front portion of the cartridge assembly and provided at its front with a pierceable central area. The cartridge assembly comprises a hollow barrel, a pierceable stopper connected to the front portion of the barrel and constituting a compartment in front of said stopper for accommodating the solid, a piston slidably accommodated in the backward portion of the barrel and constituting a compartment for liquid in the barrel, an injection needle longitudinally extending in the liquid compartment, and means for centering the distal end of the needle in order to position the needle tip towards the pierceable stopper. The front cover is capable of rotational movement relative to the outer sleeve to allow the liquid in the barrel to reach the solid compartment through the needle.Type: GrantFiled: March 24, 1993Date of Patent: October 29, 1996Assignee: Duphar International Research B.V.Inventor: Gillis P. van der Wal
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Patent number: 5549585Abstract: A gelling system for treating waste, such as bodily fluids, comprises a sealed receptacle (20) including a lid (21) and a chamber (23) within the receptacle for receiving the waste, a waste inlet port (24) in the lid connected to the interior of the chamber (23), an outlet port (25) in the lid (21) for connection to a suction source; and a container (1) for storing waste-treating material (e.g. a gelling agent), and for dispensing the waste-treating material into the chamber (23). When the suction system is in use is the container (1) is unattached to the receptacle (20) but, when it is desired to treat waste within the chamber (23), the container (1) is freely attachable to the receptacle (20) by means of an elongate dispensing nozzle (8) on the container which connects with the waste inlet port (24) to dispense the waste-treating material into the chamber.Type: GrantFiled: July 1, 1994Date of Patent: August 27, 1996Assignee: Abbott LaboratoriesInventors: Pascal J. Maher, Finbarr J. Filan, Christian Shaw
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Patent number: 5533973Abstract: An apparatus and method are disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply to a feeding tube delivering the modified liquid enteral nutritional product to the gastrointestinal tract of a patient. At least one beneficial agent not in controlled release dosage form in a useful, dose unit, amount, is disposed within a formulation chamber so as to be taken up in a liquid enteral nutritional product traversing the formulation chamber while feeding the modified nutritional product into the gastrointestinal tract of a patient. The beneficial additive(s) are selected from nutrients, medicaments, probiotics, or diagnostic agents, or mixtures thereof, each in a dosage form that is dispersible in the medium of the liquid enteral nutritional product in less than two hours.Type: GrantFiled: January 13, 1995Date of Patent: July 9, 1996Assignee: Abbott LaboratoriesInventors: Carl J. Piontek, Terrence B. Mazer, Joseph E. Walton, Ronita K. Geckle
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Patent number: 5531682Abstract: An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof.Type: GrantFiled: January 13, 1995Date of Patent: July 2, 1996Assignee: Abbott LaboratoriesInventors: Terrence B. Mazer, Joseph E. Walton, Ronita K. Geckle, Carl J. Piontek, Susan B. Duel, Andre Daab-Krzykowski, Robert L. Joseph, William G. Pierson, Thomas D. Loughrin, Thomas W. Osip
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Patent number: 5531681Abstract: An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added.Type: GrantFiled: January 13, 1995Date of Patent: July 2, 1996Assignee: Abbott LaboratoriesInventors: Joseph E. Walton, Terrence B. Mazer, Ronita K. Geckle, Carl J. Piontek, Susan B. Duel, Andre Daab-Krzykowski, Mark A. McCamish, Robert L. Joseph, William G. Pierson
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Patent number: 5512046Abstract: A dosing device for volumetric dosing of a liquid additive which is added in a certain volume ratio to a fluid, in particular withdrawn blood, flowing in a first hose line, via a second hose line feeding directly or indirectly into the first hose line. The dosing device for the volumetric dosing of an anticoagulant fluid or a sedimentation accelerator is preferably provided in a system for the collection and retransfusion of autologous blood which has a hose or tube section which extends downstream from the junction, and also a drip chamber connecting downstream from the drip tube and a light barrier, the direction of action of which is arranged transversely to the fall path of the drops. In order to avoid incorrect dosing because of changing viscosities of the liquid flowing in the first hose line, and thus of changing drop sizes, two electrically-triggerable valve means, one of which is in each case inserted into one of the two hose lines, are provided.Type: GrantFiled: November 17, 1994Date of Patent: April 30, 1996Assignee: Fresenius AGInventors: Thomas Pusinelli, Dieter Mushoff
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Patent number: 5405343Abstract: The invention is directed to a blood bag system for blood products comprising a bag (3) and at least one tubing (11) connected thereto, the system being made of at least partly transparent plastics material, wherein photoactive substances (31) may be enclosed in a closed-off section (A) of the tubing (11) of the ready-for-use system, which may be handled individually as an independent unit. Every blood bag system of this kind is adapted to be combined with another blood bag system, which may comprise one or several bags (3, 5, 7, 9) and may likewise be handled as an independent unit, by interconnecting both systems.Type: GrantFiled: September 2, 1993Date of Patent: April 11, 1995Assignee: Blutspendedienst der Landesverbande des Deutschen Roten Kreuzes Niedersachsen, Oldenburg und Bremen G GmbHInventor: Harald Mohr
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Patent number: 5395323Abstract: The invention provides a device for mixing a pharmaceutical from a solid supply into a parenterally acceptable liquid flowing through a set for parenteral administration of the liquid to a patient, said device comprising a first compartment defining a mixing space through which the liquid flows in a define flow direction and in which the liquid mixes with the pharmaceutical in liquid solution.Type: GrantFiled: April 21, 1992Date of Patent: March 7, 1995Assignee: Aktiebolaget AstraInventor: Bengt G. Berglund
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Patent number: 5385564Abstract: A system for packaging and using granulated solid dialysate concentrate. A bag is constructed to hold granulated or powder concentrate, having a V-shaped bottom with an access port in the bottom. Water is flowed through the access port and into the bag using suitable water control means. The incoming water lifts and suspends the granules or powder in a turbulent flow, thereby filling the container simultaneous with dissolving the granules or powder. The water with dissolve concentrate then constitutes the dialysis solution and is ready for use or transfer to a dialysate delivery machine.Type: GrantFiled: October 5, 1992Date of Patent: January 31, 1995Assignee: Fresenius USA, Inc.Inventors: Glenn L. Slater, Jerry Woods, Steve Alford, Dave Updyke, Rick Methe
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Patent number: 5382233Abstract: A method for teaching artistic methods and techniques by providing images on a television screen and providing means for copying such images by painting and methods for transferring the painted image to a sheet of material for display purposes.Type: GrantFiled: October 7, 1993Date of Patent: January 17, 1995Inventor: Gregory R. Brotz
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Patent number: 5342346Abstract: A fluid container comprises a drug container, a deformable solvent container, a double-pointed hollow needle having a sharp piercing edge at each end and being arranged between the drug container and the solvent container, a guide capsule with a cap rotatably mounted thereon, and a means for converting rotary motion of the cap to a linear motion of the drug container to push the drug container toward the solvent container in cooperation with the cap and the guide capsule so that a fluid communication is made between two containers through the needle.Type: GrantFiled: April 9, 1993Date of Patent: August 30, 1994Assignee: Nissho CorporationInventors: Minoru Honda, Masanobu Iwasa, Tetuzi Miyamoto, Koji Ikeda, Toshihiro Kikuchi
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Patent number: 5336180Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.Type: GrantFiled: April 26, 1993Date of Patent: August 9, 1994Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5328464Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely contolled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.Type: GrantFiled: March 19, 1993Date of Patent: July 12, 1994Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas Thompson
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Patent number: 5195967Abstract: A method for use in an intravenous tube assembly comprises the steps of automatically monitoring liquid flow along a fluid flow path extending through an intravenous catheter to detect at least a partial cessation of flow along the fluid flow path and, upon detecting a diminution of liquid flow along the fluid flow path, automatically feeding an anticlotting agent to the fluid flow path. An assembly, for implementing the method takes the form of a pressure sensing device operatively connected to the catheter for automatically detecting at least a partial cessation of liquid flow along a fluid flow path extending through the catheter.Type: GrantFiled: February 18, 1992Date of Patent: March 23, 1993Inventors: Naomi L. Nakao, Peter J. Wilk
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Patent number: 5114421Abstract: A disposable container/dispenser assembly for the extended storage and direct intravenous administration of a medicament includes a syringe barrel defining a main chamber for containing a liquid, the barrel including an upper opening in communication with the main chamber; an auxiliary barrel defining an auxiliary chamber for containing a drug to be mixed with the liquid, the auxiliary barrel including second and third spaced and opposing openings in communication with the auxiliary chamber; a first impermeable membrane for sealing the first opening of the main body; a second impermeable membrane for sealing the second opening of the auxiliary body; the first and second openings being in line with each other when the auxiliary body is connected with the main body; a third impermeable membrane secured to the auxiliary body for covering and sealing the third opening; and a plunger slidably positioned outside of the auxiliary body for rupturing the first through third membranes.Type: GrantFiled: August 30, 1989Date of Patent: May 19, 1992Inventor: Robert B. Polak
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Patent number: 5026359Abstract: An adapter comprising, an outer tube, and an inner tube defining a cavity between the inner and outer tube, with the inner tube having a plurality of openings extending therethrough. The adapter has a solid antiseptic agent in the cavity.Type: GrantFiled: February 11, 1987Date of Patent: June 25, 1991Assignee: The Kendall CompanyInventor: James E. Burroughs
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Patent number: 4994030Abstract: A kit and process for reconstituting human bone and/or related tissue is disclosed. The kit comprises a pre-formulated sterilized reconstitution medium and double ended transfer needle.Type: GrantFiled: June 28, 1988Date of Patent: February 19, 1991Assignee: Osteotech, Inc.Inventors: Frank P. Glowczewskie, Jr., David A. Present, David W. Anderson, Patrick A. McBrayer
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Patent number: 4985017Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for parenteral use including intravenous delivering for delivering an agent formulation to a patient.Type: GrantFiled: April 25, 1989Date of Patent: January 15, 1991Assignee: ALZA CorporationInventor: Felix Theeuwes
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Patent number: 4981468Abstract: An improved device for containing and administering orally active therapeutic agents is described. A unit dose of a therapeutic agent in free-flowing form is retained and positioned for oral administration in a tube adapted to deliver the dose with a flow of liquid drawn through the tube by normal sipping action of a patient. The combination of small particle size and high flow rates into the alimentary canal allow dosage administration with minimal sensed contact with the oral cavity. The invention is particularly advantageous for the administration of orally active therapeutic agents to pediatric and geriatric patients.Type: GrantFiled: January 12, 1990Date of Patent: January 1, 1991Assignee: Eli Lilly and CompanyInventors: Robert L. Benefiel, John W. Clarke, Dale C. Harris, Robert J. Morff, Peter L. Oren
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Patent number: 4915689Abstract: A parenteral delivery system for delivering a beneficial agent is disclosed. The delivery system comprises a reservoir containing a medical fluid, a vial containing a beneficial solid agent, and a manifold for establishing fluid communication between the reservoir and the vial.Type: GrantFiled: February 24, 1986Date of Patent: April 10, 1990Assignee: ALZA CorporationInventor: Felix Theeuwes
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Patent number: 4792333Abstract: The invention provides a tamper evident package for a solid oral drug dose that, after being opened, may be used for administering the dose to a patient without removing the dose from the package. The invention also provides a method for using a package for a solid oral drug dose as an aid in administering the dose contained within the package to a patient. The method of administering the packaged drug takes advantage of the normal swallowing reflex, thus facilitating oral ingestion of the dose, and positively identifies the drug up to an including the act of drug ingestion by the patient.Type: GrantFiled: November 4, 1986Date of Patent: December 20, 1988Assignee: Strawdose, Inc.Inventor: Samuel W. Kidder
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Patent number: 4745907Abstract: To deliver a controlled dosage of an insoluble material into a living body, the material is provided in measured amounts in vials, and a system is provided for flushing the entire content of insoluble materials from the vial into the body. Insoluble radioactive material, such as glass microspheres incorporating radioactive isotopes, are packaged in a plurality of vials, preferably with different amounts of material. An accurate dosage of radioactivity can be delivered by administering the entire contents of one or more vial(s) according to the sum of radioactivity in selected vials as determined by the initial measurement of radioactivity and by the natural half-life of the isotope.Type: GrantFiled: September 16, 1987Date of Patent: May 24, 1988Assignee: Nuclear Medicine, Inc.Inventors: John L. Russel, Jr., John L. Carden
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Patent number: 4743229Abstract: A mixing device for preparing inductive and conductive bone repair compositions is disclosed, along with a method for using the device for preparing such compositions. The device provides a simple and rapid method of making a substantially uniform collagen/mineral bone implant preparation.Type: GrantFiled: September 29, 1986Date of Patent: May 10, 1988Assignee: Collagen CorporationInventor: George Chu
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Patent number: 4741734Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.Type: GrantFiled: February 15, 1985Date of Patent: May 3, 1988Assignee: Alza CorporationInventor: Felix Theeuwes
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Patent number: 4740199Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.Type: GrantFiled: February 14, 1985Date of Patent: April 26, 1988Assignee: ALZA CorporationInventor: Felix Theeuwes
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Patent number: 4740103Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.Type: GrantFiled: February 15, 1985Date of Patent: April 26, 1988Assignee: ALZA CorporationInventor: Felix Theeuwes
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Patent number: 4740197Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.Type: GrantFiled: February 14, 1985Date of Patent: April 26, 1988Assignee: ALZA CorporationInventor: Felix Theeuwes
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Patent number: 4740198Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.Type: GrantFiled: February 15, 1985Date of Patent: April 26, 1988Assignee: ALZA CorporationInventor: Felix Theeuwes
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Patent number: 4735608Abstract: A container for intravenous fluid has a triangular cross-section to permit improved utilization of space during packaging of several containers in boxes or cartons, and a first opening sealed by a membrane seal which can be pierced with the spike of a conventional intravenous set. A second opening of the container is surrounded with a neck portion forming a joint to which an intermediate member is pivotably mounted. The intermediate member includes a hollow cylindrical portion having two circumferential ribs which are adapted to hold the neck of a standard small vial containing solid antibiotics and the like. The intermediate member also includes an internally mounted hollow spike so that the seal of the antibiotic vial is penetrated by the spike when the vial is mounted to the intermediate member. The duct of the spike of the intermediate member is not aligned with the second opening of the container until the intermediate member is rotated or pivoted into an extreme position.Type: GrantFiled: May 14, 1986Date of Patent: April 5, 1988Assignee: Del F. KahanInventor: William W. Sardam
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Patent number: 4695272Abstract: A drug release device for inclusion in a parenteral drug delivery system, said device comprising a chamber having an inlet for a liquid administerable to a patient by a parenteral route, a drug dissolution space within said chamber, through which said liquid can be made flow, an outlet for said liquid, and means for receiving and retaining within said drug dissolution space a drug preparation from which a drug is releasable to said liquid during such parenteral delivery, said device characterized in having means for providing the same with one or more durg release cells within which such drug preparation is initially held isolated from the liquid, each of said drug cells having means for emptying its contents of drug preparation into said drug dissolution space after insertion thereof in the drug release device.Such device can be used for sequential emptying of a drug preparation from two or more such drug cells whereby a parenteral liquid dissolves the drug.Type: GrantFiled: April 23, 1985Date of Patent: September 22, 1987Assignee: Aktiebolaget HassleInventors: Bengt G. Berglund, Karl-Erik L. Falk, Dan A. Magnusson, Nils B. Nilson, Ake S. Nilsson
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Patent number: 4681582Abstract: A drug administering apparatus includes a container with body fluid inlet and outlet ports which communicate with each other, and a liposome agent entrapping a drug therein. An insoluble substance is fixed inside the container and has the liposome agent such that the liposome agent can be brought into contact with the body fluid flowing in the container. The drug entrapped in the liposome is released into the body fluid flowing in the container.Type: GrantFiled: June 11, 1985Date of Patent: July 21, 1987Assignee: Terumo Kabushiki KaishaInventor: Yuichi Yamamoto
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Patent number: 4627836Abstract: Novel cardiovascular prosthetic devices or implants having many useful cardiovascular applications comprise a porous surface and a network of interconnected interstitial pores below the surface in fluid flow communication with the surface pores. Tissue forms a smooth thin adherent coating of self-determining thickness on the porous surface making it resistant to the formation of the blood clots normally associated with the presence of foreign bodies in the blood stream. The device has particular utility in heart valves, pacemaker electrodes, blood pumps, blood stream filters, an artificial pancreas, vascular access tubes, small and large bore vascular grafts, blood pump diaphragms and vascular and intracardiac patches.Type: GrantFiled: June 30, 1983Date of Patent: December 9, 1986Inventor: David C. MacGregor
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Patent number: 4606734Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by attaching an additive assembly with a piercing element to an additive port of the diluent container to pierce a diaphragm in the additive port and a diaphragm or stopper in the additive container. In one embodiment, the additive assembly includes a bellows portion which will permit movement of the piercing element through the additive assembly stopper and the port diaphragm while maintaining a sterile medicament in a glass vial.Type: GrantFiled: February 22, 1984Date of Patent: August 19, 1986Assignee: Abbott LaboratoriesInventors: Mark E. Larkin, Ralph M. Quin
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Patent number: 4581013Abstract: A device for orally administering medication by inclusion of a diluent liquid with the medication ingested into the oral cavity. The dosing device in one embodiment has a mouthpiece, a first conduit means for providing a stream of liquid diluent and a second conduit means for positively injecting a liquid medication into the stream of diluent liquid. The dosing device additionally includes as a preferred feature means for supporting a solid medication within the mouthpiece for inclusion within a stream of diluent liquid. In another embodiment, the dosing device comprises a container for solid medicine which is a tubular mouthpiece having a closure cap and a radially flanged base plate for support of the mouthpiece in upright position on a support surface, and a support grid in the tube for the solid medicine.Type: GrantFiled: August 4, 1983Date of Patent: April 8, 1986Assignees: Jane C. A. Hayes, Angela B. Allen, Ashley J. AllenInventor: Randy B. Allen
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Patent number: 4564005Abstract: An oral irrigation assembly of the type designed to be used in combination with a conventional water outlet such as an outlet associated with a showerhead or like water dispersement means. A water conduit includes a first and second channel structured to deliver water concurrently to the showerhead and to an assembly specifically structured to cause pulsing water flow to issue from the water conduit to an irrigating applicator preferably in the form of a nozzle or the like. A valve structure is disposed in water regulating relation to the second channel such that water flow may be selectively stopped when use of the oral irrigating device is not desired but water flow from the showerhead is maintained.Type: GrantFiled: December 5, 1983Date of Patent: January 14, 1986Inventors: Paul A. Marchand, Noel W. Abramson
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Patent number: 4534758Abstract: Valved adaptors are disclosed permitting the introduction of a drug-containing vial in the delivery tube of an I.V. administration set. The adaptors have a three position operation characterized by a bypass mode, a dilution mode, and a delivery mode, the adaptors being manually changed from mode to mode. The disclosed adaptors include gravity operated valves, reciprocating spool valves, and rotating spool valves, each including a spike to penetrate the stopper of a vial and a vent to permit air to escape the vial as liquid is introduced to dilute the vial contents.Type: GrantFiled: July 15, 1983Date of Patent: August 13, 1985Assignee: Eli Lilly & CompanyInventors: Michael J. Akers, William W. Hargrove, Dale C. Harris, Charles R. Sperry
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Patent number: 4479796Abstract: An implantable dispenser for infusing a desired drug into the blood stream. The dispenser is adapted to be spliced into a blood vessel so that blood flows freely through it. Within the dispenser is a replaceable biomass cartridge containing a colony of microorganisms which produce the drug.Type: GrantFiled: November 15, 1982Date of Patent: October 30, 1984Assignee: Medtronic, Inc.Inventor: Michael J. Kallok