Means For Intermixing Liquid With Solid Or Different Liquid Patents (Class 604/82)
  • Patent number: 10417384
    Abstract: A medical device connection station comprising a body having a first portion of a docking interface to dock with a corresponding second portion of a docking interface of a medical device, a control unit controlling a medical device communication interface for communication with a docked medical device and controlling a server communication interface. The control unit is configured acquire medical data from a docked medical device via the medical device communication interface and is further configured to connect with and obtain a data session with the server system via the server communication interface, and to thereby transfer the medical data to the server system.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 17, 2019
    Assignee: ARES TRADING S.A.
    Inventors: Gerhard Lauchard, Gerhard Walder, Alexander Legner, Eric Chanie, Georgios Kouvas
  • Patent number: 10279053
    Abstract: A method of forming a plurality of microbubbles, wherein the method disposes in a sealed container comprising a first volume at ambient pressure, a second volume of a mixture comprising one or more microbubble stabilizing materials. The first volume is greater than said second volume. The method further comprises sealing said container, introducing a gas into said sealed container, and shaking the container to form said plurality of microbubbles.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: May 7, 2019
    Assignee: NuvOx Pharma LLC
    Inventors: Evan C. Unger, Patrick W. Hendon
  • Patent number: 10265701
    Abstract: A container for taking up and dispensing a substance includes a glass tubule, a glass punch that slides adjustably in the glass tubule, forming a seal, and a glass sleeve closed on one side, in which the glass tubule is accommodated. The glass sleeve is shorter than the glass tubule, so that the glass tubule projects out of the glass sleeve. The glass punch is longer than the glass tubule and projects out of the glass tubule at the end situated outside of the glass sleeve. The glass punch does not fill the glass tubule completely, so that a substance chamber remains in the region of the end of the glass tubule situated within the glass sleeve.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: April 23, 2019
    Assignee: Chemspeed Technologies AG
    Inventors: Rolf Gueller, Michael Schneider, Thomas Thaler, Markus Schindler
  • Patent number: 10265266
    Abstract: A handheld device for mixing a liquid and a gas to form foam before a treatment procedure comprises: an inlet for letting a liquid enter the device, the inlet adapted for attachment to a syringe containing the liquid, an outlet for letting a formed foam exit the device, a chamber containing a gas, the chamber comprising the inlet and outlet, at least one agitation element disposed in the chamber, the at least one agitation element is arranged for independent movement in at least one degree of freedom, the at least one agitation element sized and shaped to mechanically agitate liquid flowing past the at least one agitation element, the liquid flowing in an overall inlet-to-outlet direction, the agitation being sufficient for the at least some of the liquid to mix with the gas to produce the formed foam; the device is dimensioned for holding in one hand.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: April 23, 2019
    Assignee: V.V.T. Med Ltd.
    Inventor: Zeev Brandeis
  • Patent number: 10201659
    Abstract: An administration device comprises a container and a mixing device for mixing an active substance (in a first chamber) with a dilution liquid (in a second chamber). The container has a membrane seal at one end and is combined with a mixing device for mixing the active substance. The administration device has an injection needle unit with a distal needle portion facing away from the container for piercing the skin, and disposed opposite thereto is a proximal needle portion facing the membrane when the administration device is in the initial position, which is thrust through the membrane into the container in a mixing position. The administration device includes a protective sleeve arranged coaxially about the injection needle, movable from the initial position only in the proximal direction relative to the container. The protective sleeve can be non-rotatably connected to the container in the mixing position and rotated relative to the mixing device to perform mixing.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: February 12, 2019
    Assignee: TecPharma Licensing AG
    Inventors: Nadine Kaufmann, Jürg Hirschel, Markus Tschirren
  • Patent number: 10143625
    Abstract: A device is disclosed for reconstitution and delivery of an injectable pharmaceutical. A pharmaceutical composition such as a lyophilized drug is provided in a pressurizable fluid reservoir with a pierceable seal. A diluent may be separately provided in a syringe with a needle. When the needle is driven through the seal and the plunger is actuated, fluid from the barrel of the syringe flows into the pressurizable fluid reservoir to simultaneously pressurize the reservoir and mix the diluent with the drug. Pressurized in this manner, the reservoir can then automatically and without further user intervention push the mixture back through the needle and into the barrel of the syringe, further mixing the composition and displacing the plunger to fill the barrel with the reconstituted drug. The needle and syringe can then be detached from the reservoir with the reconstituted drug contained in the barrel and ready for injection.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: December 4, 2018
    Assignee: Recon Therapeutics, Inc.
    Inventors: Xiang Li, Benjamin E. Maimon, Ho-Jun Suk
  • Patent number: 10137240
    Abstract: The invention is related to a dispense interface for a drug delivery device for delivering at least two drug agents, comprising at least two two-ended flow regulation structures and a confluence, wherein each flow regulation structure comprises a fluid inlet opening at a first end, wherein each flow regulation structure comprises a fluid outlet opening connected to the confluence at a second end of the respective flow regulation structure and wherein at least one of the two-ended flow regulation structures comprises a capillary fluid channel. The invention is further related to a drug delivery device for delivering at least two drug agents comprising a dispense interface of the aforementioned kind, to a method for delivering at least two drug agents through an injection means of a drug delivery device and to a method for manufacturing a dispense interface of the aforementioned kind.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: November 27, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: David Moore
  • Patent number: 10046153
    Abstract: A connector includes in a main body, first to third ports each having a flow channel allowing inflow or outflow of an infusion solution, an internal flow channel configured to communicate between flow channels of the first port and the second port, and a through hole connected to an internal flow channel. In the internal flow channel, an upstream side wall surface is provided which guides infusion solution flowing into the internal flow channel from the first port to the through hole, and reduces the cross-sectional area of the flow channel for the infusion solution near the through hole relative to the cross-sectional area of the flow channel of the first port in order to increase a flow rate of the infusion solution.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: August 14, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuhiro Ueda, Tsukasa Takahashi
  • Patent number: 10035003
    Abstract: The present invention relates to a dual balloon catheter with controlled expansion and solution flow, a multi-port manifold and a dual syringe delivery device and method with intended use in sclerotherapy.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: July 31, 2018
    Inventor: Dennis L Steffen
  • Patent number: 9999729
    Abstract: A reservoir assembly comprising a reservoir housing, a piston, and a locking plug, both movably arranged inside the reservoir housing; wherein the volume between the piston and the locking plug defines a reservoir cavity. The reservoir assembly further comprising a reservoir outlet; and an actuator configured to act on the piston; wherein the locking plug is configured to be movable from a first position to a second position; wherein in the first position the reservoir outlet is not in fluid communication with the reservoir cavity. The reservoir assembly further comprising an interlock configured to prevent movement of at least one of the locking plug and the piston; wherein the interlock having a locked position and an unlocked position.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: June 19, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Philippe Nzike, Michael Schabbach, Bernd Petermann, Olaf Zeckai, Meinolf Werner, Ole Simonowsky
  • Patent number: 9999427
    Abstract: In various aspects, present disclosure is directed to methods, devices and systems whereby one or more low viscosity fluids may be introduced into a catheter and whereby the one or more low viscosity fluids may be converted into a high viscosity fluid in the catheter, which high viscosity fluid may be delivered from an exit port of the catheter.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: June 19, 2018
    Assignee: ARSENAL MEDICAL, INC.
    Inventors: Gregory T. Zugates, Joseph Lomakin, Jennifer Mortensen, Jeffrey Groom, II, John Marini, Stephanie Webber
  • Patent number: 9974942
    Abstract: This disclosure relates to fluid line sets and related methods. In certain aspects, the fluid line sets include a vial adapter connected to a first end of a fluid line, and a cap removably attached to a second end of the fluid line such that the cap seals the second end of the fluid line. The vial adapter includes a base, a spike extending from a central region of the base, and a sidewall extending from the base and substantially surrounding the spike. The base and the side wall at least partially define a cavity configured to receive a portion of a vial. The cap includes a deformable portion at least partially defining a gas chamber, and the cap is configured so that deformation of the deformable portion causes gas to be forced from the gas chamber to the vial adapter via the fluid line.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 22, 2018
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Michael James Beiriger
  • Patent number: 9907572
    Abstract: An embryo transfer syringe has a roller (30) coupled with the rear end of its plunger (15). The roller (30) is displaceable along an elongate housing (20) extending from the rear of the barrel (10) of the syringe. The roller (30) can be manually engaged through a slot (23) along the housing (20) to rotate it and roll it along the housing thereby smoothly and controllably displacing the plunger (15).
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: March 6, 2018
    Assignee: The Cooper Companies Global Holdings LP
    Inventor: Stephen James Field
  • Patent number: 9857383
    Abstract: Embodiments of the present invention relate to multiple coagulation test cartridges and methods of using such cartridges. In one embodiment the cartridge is a disposable single-use cartridge for use in evaluating blood clotting. The cartridge includes multiple containers, such as tubes, each of which includes one or more coagulation affecting substances. The containers can be pre-filled with substances in amounts suitable for use with a single patient's blood sample. The cartridge may include one or more containers, each of which has multiple sections, or volumes, each section storing a different coagulation affecting substance. In another embodiment the cartridge is used in a method for determining at least one appropriate coagulation affecting substance for modifying a patient's coagulation status using a multiple coagulation test system.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: January 2, 2018
    Inventor: Sheldon Goldstein
  • Patent number: 9833578
    Abstract: A medicament delivery device includes a distal housing part; a proximal housing part for a container; a drive mechanism in the distal housing part that includes a plunger rod; and an auto mixing mechanism. The housing parts are movable from a first position, in which the housing parts are partially extended relative to each other, to a second position, in which the housing parts are partially retracted relative to each other. The auto mixing mechanism is configured to hold the housing parts in the first position and to lock the housing parts in the second position, and includes a mixing force member operably arranged between the housing parts such that manual activation of the auto mixing mechanism enables the mixing force member to cause the housing parts to move from the first position to the second position. The plunger rod acts to mixing a medicament in the container.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: December 5, 2017
    Assignee: Carebay Europe Ltd
    Inventor: Gunnar Elmén
  • Patent number: 9782210
    Abstract: A technique for simultaneously forming a plurality of paste filled tunnels. The plurality of paste filled tunnels are connected to a surgical tube directly or indirectly and emptied one after another, until a desired amount of the paste is injected into a bone cavity, organ or a tissue via the surgical tube. The paste may be a bone cement paste, a drug powder paste, viscous fluid or gel. The injected bone cement paste will set in the bone cavity to act as a medical implant.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: October 10, 2017
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju
  • Patent number: 9662451
    Abstract: A device useful for making retrobulbar injections includes an inner syringe contained within an outer syringe. A spring retained within the outer syringe biases the inner syringe proximally, which a catch mechanism on the two syringes prevents the inner syringe from moving out of the outer syringe. A distal needle on the inner syringe is movable within a distal sheath of the outer syringe, and can be extended beyond the distal end of the sheath to permit the device to piece more resilient tissues, and can be withdrawn by action of the spring within the sheath to protect more delicate tissues from the needle.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: May 30, 2017
    Inventor: Bruce Becker
  • Patent number: 9604006
    Abstract: The present invention relates to a cartridge for a drug delivery device, comprising a barrel of substantially cylindrical shape and at least one piston arrangement displaceably arranged in the barrel, wherein the piston arrangement occupies at least 20% of the volume confined by the barrel.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: March 28, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Axel Teucher, Michael Jugl
  • Patent number: 9579449
    Abstract: Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 28, 2017
    Assignee: Arsenal Medical, Inc.
    Inventors: Upma Sharma, Rany Busold, Adam Rago, Gregory T. Zugates, Toby Freyman, Lisette Manrique Miller
  • Patent number: 9511118
    Abstract: A sub-atmospheric, negative pressure is applied to a growth factor starting material, such as whole blood, to release growth factors and plasma in a non-destructive medium. The released growth factors having a weight of about 70-76 kDaltons are applied in either a filtered or unfiltered state to a wound to promote healing of the wound. The released growth factors are applied topically to the area of a surface wound to effect healing. The released growth factors are also injected into soft tissue, such as a torn tendon, to promote tissue growth and healing. The growth factors are released in one method from a patient's own blood. In another method the growth factors are released from a whole blood source and freeze dried by conventional lyophilization. Then at a later date, the freeze dried product is reconstituted by normal saline for treatment of a patient's wound or for use in a surgical procedure.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 6, 2016
    Assignee: PGFX PATENT HOLDINGS, LLC
    Inventors: James B Gandy, Robert J Brandt, Ryan N Brandt, Clark Galen, Joseph Greco, John Kiwczak
  • Patent number: 9445855
    Abstract: The present invention is related to a technique for simultaneously forming a plurality of paste filled tunnels. The plurality of paste filled tunnels are connected to a surgical tube directly or indirectly and emptied one after another, until a desired amount of the paste is injected into a bone cavity, organ or a tissue via the surgical tube. The paste may be a bone cement paste, a drug powder paste, viscous fluid or gel. The injected bone cement paste will set in the bone cavity to act as a medical implant.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: September 20, 2016
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju
  • Patent number: 9399097
    Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments are delivered through a single hollow needle (5). The medicated module (4) is user selectable so that it will deliver both the primary (1) and secondary medicaments (2), or only the primary medicament (1). The module (4) also contains a guard (42) that locks after dose delivery.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: July 26, 2016
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
  • Patent number: 9375108
    Abstract: A device for oral application of a substance, comprising an inner tube surrounding a first volume an outer tube surrounding a second volume, the second volume comprising a cavity section adjoining an inlet opening of the outer tube being adapted for containing the substance, a separation area arranged in the second volume, the separation area adjoining the cavity section and the first volume, and a selective connecting passage between the cavity section and a pressure compensation space to selectively enable a flow of the substance from the cavity section though the first volume. A kit-of-parts, comprises the inventive device a predefined amount of a substance being contained in a receptacle or the cavity section, and instructions for the use of the substance. Methods for filling the inventive device as well as to a method for oral application using the inventive device are provided.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: June 28, 2016
    Assignee: SANDOZ AG
    Inventors: Franz Xaver Schwarz, Thomas Jakob, Robert Reichenberger
  • Patent number: 9359122
    Abstract: A discharging system (100, 200, 300, 400, 500) for discharging liquid to pasty compounds (107, 207, 30, 507) out of cavities (106, 206, 306, 506) of at least two containers (105, 205, 305, 405, 405?, 505), comprising a delivery end (109, 209, 309, 409, 509) at which the compounds (107, 207, 307, 507) are discharged; a receiving unit (101, 201, 301, 401, 401?, 501) for at least two containers (105, 205, 305, 405, 405?, 505) comprising the cavities (106, 206, 306, 506) filled with the compounds (107, 207, 307, 507) to be discharged; for each container, a respective advancing rod (103, 203, 303, 403, 403?, 503) with a pusher element (104, 204, 304, 504) provided on that side of the advancing rod (103, 203, 303, 403, 403?, 503) facing toward the delivery end (109, 209, 309, 409, 509); for each container, a respective advancing device for advancing the advancing rod (103, 203, 303, 403, 403?, 503), with the pusher element (104, 204, 304, 504), toward the delivery end (109, 209, 309, 409, 509) in order to discharge
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: June 7, 2016
    Assignee: Henkel AG & Co. KGaA
    Inventors: Christoph Schmid, Thomas Daum
  • Patent number: 9283016
    Abstract: A method for treating a vertebral bone comprises providing a gaseous substance and providing a flowable and settable bone filling material. The method further comprises introducing the gaseous substance into the bone filling material to form a porous bone augmentation material and inserting a material delivery device into the vertebral bone. The method further comprises injecting the porous bone augmentation material from the material delivery device and into the vertebral bone.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: March 15, 2016
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Hai Trieu, Aashiish Agnihotri, Joseph Saldino
  • Patent number: 9220553
    Abstract: A method for treating a vertebral bone comprises providing a bone filling material and mixing the bone filling material in a vessel to form a bone augmentation material. The method further comprises pressurizing the vessel with a pressurization source to retain a plurality of voids within the bone augmentation material. The method further includes inserting a material delivery device into the vertebral bone and injecting the bone augmentation material with the retained plurality of voids from the material delivery device and into the vertebral bone.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: December 29, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Hai H. Trieu, Aashiish Agnihotri, Joseph Saladino
  • Patent number: 9132235
    Abstract: A medicament delivery device includes a housing arranged to receive a medicament container, a drive unit arranged to act on a stopper in the medicament container, which drive unit includes a torsion drive spring. A dose setting member is operably connected to the drive unit such that a manual turning of the dose setting member causes a tensioning of the torsion drive spring. The device also includes an activation mechanism having an activation button protruding through a distal end of the device. The activation mechanism is operably connected to the drive unit such that actuation of the activation mechanism causes a release of the drive unit, with a set dose of medicament delivered.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: September 15, 2015
    Assignee: SHL Group AB
    Inventor: Anders Holmqvist
  • Patent number: 9125990
    Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: September 8, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan
  • Patent number: 9095661
    Abstract: An apparatus for controlling a fluid flow rate in a fluid transport line of a medical device, including at least a first pump, at least a chamber for collecting the fluid, at least a sensor for providing a first value correlated to the amount of fluid in the chamber, and a control device configured for receiving a second value representative of the fluid flow rate through the first pump and for correlating the second value with the first value to obtain an accuracy check of the second value. A method for controlling a fluid flow rate in a fluid transport line of a medical device including pumping a fluid, collecting the fluid in a chamber, sensing a first value correlated to the amount of fluid in the chamber, and detecting and sending a second value representative of the fluid flow rate through the first pump to a control device, sending the first value to the control device, and correlating the second value with the first value to obtain an accuracy check.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: August 4, 2015
    Assignee: Gambro Lundia AB
    Inventor: Bernard Bene
  • Patent number: 9089680
    Abstract: A connector comprises a housing; a main flow path being configured such that fluid is flowable from a first tube through the main flow path into a second tube; and a connection terminal including a connection side space, the connection terminal being configured such that a third tube is connectable to the connection terminal and an auxiliary flow path of the third tube communicates with the main flow path via the connection side space. The main flow path includes a main flow path side space that is continuous with at least the connection side space and is defined by: a bottom part facing the connection side space and a pair of side parts extending from opposite sides of the bottom part toward the connection side space, and at least one wall surface configured to direct the fluid toward the connection side space and toward at least one of the side parts.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: July 28, 2015
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuhiro Ueda, Yasunobu Zushi
  • Patent number: 9072841
    Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: July 7, 2015
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Thomas Urs Thueer, David Richard Mercer, Garen Kouyoumjian, Malcolm Stanley Boyd
  • Publication number: 20150141906
    Abstract: Methods and devices are disclosed to reduce the tissue trauma that occurs when a physician retracts or otherwise deforms a patient's tissues for surgery or other medical procedures. In one part, methods and devices are disclosed for cooling the tissue around the incision. In another part, methods and devices are disclosed that elute drugs into the tissues of the tissue margin. In another part, methods and devices are disclosed to engage tissues during retraction to cushion, to sense tissue state, and to modulate tissue state.
    Type: Application
    Filed: December 19, 2014
    Publication date: May 21, 2015
    Inventors: Charles Anthony Pell, Hugh Charles Crenshaw
  • Patent number: 9022975
    Abstract: The invention described herein is a device for dripping a tissue sealant and/or adhesive that comprises a) first and second barrels or syringes that contain first and second biocomponents that are disposed between proximal and distal ends; b) a plunger in each barrel and c) a drip tip comprising i) a support having distal and proximal ends and at least two fluid passageways from the distal to the proximal end that are in fluid communication with one of the barrels of the dispensing device on the proximal end; and ii) an endcap that fits over the support having at least two flexible hinges. The present invention is also directed to an assembly for mixing and drip dispensing two reactive biologic components as tissue sealant and/or hemostatic agent and to methods for delivering biologic components to achieve hemostasis and/or tissue sealant by drip dispensing from the device described above.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: May 5, 2015
    Assignee: Ethicon, Inc.
    Inventors: John Goodman, Sonia Martins, Joseph B. Bilotta
  • Patent number: 9005183
    Abstract: A treatment for male erectile dysfunction comprising separately storing a lyophilized composition of vasoactive agents and a carrier gel, mixing said lyophilized composition of vasoactive agents and said carrier gel creating a homogeneous mixture and applying said homogeneous mixture to the meatus of the glans penis. A system for the treatment of male erectile dysfunction comprising a syringe coupling system for the storage, mixing and application of therapeutic compounds for the treatment of erectile dysfunction, said system further comprising a first syringe and a second syringe. The first and second syringes are filled with a lyophilized composition of vasoactive agents or a carrier gel. The system includes a locking device coupling said syringes to facilitate the transfer of said lyophilized composition of vasoactive agents and carrier gel between the syringes and a penile adapter for applying the therapeutic compounds for the treatment of erectile dysfunction to the meatus of the glans penis.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: April 14, 2015
    Assignee: Health Knight, LLC
    Inventor: Thomas John Harkins, Jr.
  • Patent number: 8979831
    Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. The chemical reaction energy is provided by chemical reactions including a highly reactive electrophilic reagent provided to a target tissue location.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: March 17, 2015
    Assignee: Regents of the University of Minnesota
    Inventor: Erik N. K. Cressman
  • Patent number: 8979791
    Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: March 17, 2015
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: James Alexander Davies, Steven Wimpenny, Daniel Thomas De Sausmarez Lintell, Malcolm Stanley Boyd, Naceur Rekaya, Simon Lewis Bilton, John David Cross
  • Patent number: 8979792
    Abstract: Inline liquid drug medical device having a longitudinal device axis, a housing with a linear displaceable sliding flow control member displaceable along a transverse bore from a first flow control position for establishing flow communication between a first pair of ports for liquid drug reconstitution purposes to a second flow control position for establishing flow communication between a second pair of ports for liquid drug administration purposes, and a manually operated actuating mechanism for applying a linear displacement force for urging the flow control member to slide along the bore from its first flow control position to its second flow control position.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: March 17, 2015
    Assignee: Medimop Medical Projects Ltd.
    Inventors: Nimrod Lev, Igor Denenburg, Moshe Gilboa
  • Patent number: 8974400
    Abstract: A tissue harvesting and processing apparatus comprises a body and a distally extending needle. The needle includes an aperture configured to receive tissue. A tissue cutting member is movable relative to the needle to sever a specimen from tissue protruding through the aperture. The tissue cutting member is further operable to mince the severed tissue specimen. The minced tissue may be mixed with a medical fluid component contained in a reservoir. A plunger may expel the medical fluid mixture from the needle. An applier tip may be coupled with the needle to facilitate administration of the medical fluid mixture at a target site in a patient. The needle may comprise a cannula with a needle adapter, which be removed from the cannula to allow the applier tip to be coupled with the cannula. The tissue cutting member may comprise a perforated disc or tube with inwardly projecting blades.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: March 10, 2015
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Jeffrey S. Swayze, Mark H. Ransick
  • Patent number: 8974436
    Abstract: A malleable cannula having multiple lumens, constrained at the proximal end portion to provide rigidity and malleable at the distal end portion. The cannula has a combination of flexibility and stiffness that assists in accessing body passageways without kinking.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: March 10, 2015
    Assignee: Medtronic Xomed, Inc.
    Inventors: Ethan G. Sherman, David J. Little, Wei Chen, John R. Prisco, Matthew J. Friend, Matthew F. Myntti, Tom Zelmer, Cyan Godfrey, Roy Attride
  • Publication number: 20150065951
    Abstract: Delivery catheters for in situ forming foams are provided. The catheters include, in various embodiments, coatings, valves, mixing structures, exit ports and combinations of the same.
    Type: Application
    Filed: August 29, 2014
    Publication date: March 5, 2015
    Inventors: Toby FREYMAN, Jennifer Mortensen, Jeffrey Groom
  • Patent number: 8961455
    Abstract: A medicament delivery device includes a housing having a proximal housing part and a distal housing part movable relative each other, a drive force mechanism accommodated in the distal housing part, a container filled with medicament arranged within the proximal housing part, a holding member for holding the drive force mechanism in a loaded state, and an actuation member arranged to interact with the holding member for releasing the drive force mechanism from its loaded state. The holding member is arranged to be moved from a disengaged position, in which the holding member is disengaged from the actuation member, to an engaged position, in which the holding member is engaged to the actuation member by moving the housing parts in relation to each other.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: February 24, 2015
    Assignee: SHL Group AB
    Inventors: Anders Holmqvist, Sebastian Karlsson
  • Publication number: 20150045773
    Abstract: A steroid delivery system including a mixing syringe having a first chamber and a second chamber and at least one hypodermic needle is provided. The first chamber of the mixing syringe contains a pre-measured volume of a local anesthetic and the second chamber contains a pre-measured volume of a corticosteroid. An improved mixing syringe and a method for treating pain using the steroid delivery system of the present invention is also provided herein. The improved syringe achieves mixing without the introduction or elimination of air and without puncturing or rupturing of a membrane, diaphragm or other material. The kit concept improves the speed of the procedure, sterility, accuracy of dosing, and immediate availability of disparate items to implement the procedure in a variety of medical practice settings.
    Type: Application
    Filed: October 23, 2014
    Publication date: February 12, 2015
    Inventor: Michael P. Connair
  • Publication number: 20150045768
    Abstract: Techniques, kits and a delivery instrument for providing a material at a defect repair site. The instrument is a combined delivery needle/elevator/paddle that includes a delivery needle and a paddle/elevator tip attached to the end of the needle and around the most distal opening of the needle. The combined needle/elevator/paddle instrument allows both delivery (insertion or injection) of the material/mixture as well as leveling/flattening of the delivered material. The mixture/material may be micronized allograft tissue such as BioCartilage® and the surgical site may be a defect site such as a microfracture site or cartilage defect.
    Type: Application
    Filed: August 6, 2014
    Publication date: February 12, 2015
    Inventors: Reinhold Schmieding, Brandon L. Roller, Robert Benedict, Marc Stoll, James R. McWilliam
  • Publication number: 20150018760
    Abstract: A nasal irrigation system for rinsing nasal and sinus passages or cavities includes a solution preparation unit and a dispensing container. The solution preparation unit includes a first water reservoir, a filter that is in fluid communication with an outlet of the first water reservoir and filters water passing therethrough, a second water reservoir that is in fluid communication with the filter, and a heating element that brings filtered water in the second water reservoir to a boil to clean the filtered water, and a filler port. The dispensing container receives a nasal rinse solution from the solution preparation unit, via the filler port, and administers the nasal rinse solution to a user via a direct nostril interface. The solution preparation unit can also include a cooling element, additive reservoirs for materials to calibrate salinity or to provide a pH buffer, and a control circuit to control operation thereof.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Kathryn Morton HARDIN, James Craig HARDIN
  • Publication number: 20150010528
    Abstract: An anesthetic composition for use e.g. in the administration of a local anesthetic by injection comprises a first component, which comprises hyaluronidase, and a second component which comprises an anesthetic preparation. The composition is both effective and highly shelf stable, and has as an advantage that it may be stored and administered at room temperature. In a particular embodiment, the hyaluronidase is prepared in dry powder form, as by lyophilization. The anesthetic component may be selected from a group of known anesthetics, such as lidocaine, polocaine, xylocaine, novocaine, procaine, prilocaine, bupivacaine, mepivacaine, carbocaine, etidocaine and chincocaine. The composition may be prepared in unit dosage forms, including a single dosage form, for a variety of purposes, and such unit dosage forms may be prepared in a plural chambered syringe or like dispenser, whereby the components are not mixed until administration.
    Type: Application
    Filed: March 31, 2014
    Publication date: January 8, 2015
    Inventor: Stuart L. WEG
  • Patent number: 8926586
    Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: January 6, 2015
    Assignee: Regents of the University of Minnesota
    Inventor: Erik N. K. Cressman
  • Patent number: 8920367
    Abstract: An apparatus includes a medicament container assembly, a movable assembly, and a spring. The medicament container assembly includes a first plunger defining a first volume, and a second plunger defining a second volume. The movable assembly includes a first movable member and a second movable member. The second movable member can move the second plunger within the medicament container assembly. The first movable member can move the first plunger in a first direction within the medicament container assembly to expel a contents of at least the first volume via a needle. The spring is configured to urge the needle in a second direction. The release portion of the first movable member is configured to contact the second movable member after the first movable member moves the first plunger to enable the spring to move the needle in the second direction.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 30, 2014
    Assignee: kaleo, Inc.
    Inventors: Eric Shawn Edwards, Evan Thomas Edwards, Mark J. Licata, Paul F. Meyers
  • Publication number: 20140371721
    Abstract: A system for mixing and dispensing at least first and second components of a biomaterial. The system includes a first syringe including a barrel having a proximal and distal ends. The barrel is configured to receive the first and second components of the biomaterial. There is a cap on the distal end of the barrel. The cap has an opening to allow materials to be directed into the barrel. The system further includes a mixing member. At least a portion of the mixing member is configured to enter the barrel through the cap. The mixing member is configured to move at least axially within the barrel to mix the first and second components.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 18, 2014
    Inventors: Benjamin B. Anderson, Mark Stevenson
  • Publication number: 20140371670
    Abstract: A medicament delivery device for a reconstituted medicament, comprising a proximal housing part (12; 12?; 12??), a distal housing part (10; 10?; 10??), a medicament delivery drive unit and actuation means, wherein the medicament delivery drive unit is mounted in said distal housing part and wherein the actuation means further include an activation member (74; 101; 201) which is displaceable between an inactive position wherein the actuator is prevented from engaging the medicament delivery drive unit and an active position wherein the actuator is able to engage the medicament delivery drive, whereby the actuator is capable of interacting with said medicament delivery drive unit to perform a delivery of the reconstituted medicament only in the active position of the activation member and in the second position of the medicament delivery drive unit.
    Type: Application
    Filed: January 31, 2012
    Publication date: December 18, 2014
    Applicant: SHL GROUP AB
    Inventors: Anders Holmqvist, Stefan Lööf
  • Patent number: 8905996
    Abstract: A set of instruments configured to deliver a therapy to a bone can include a cannulated syringe. The cannulated syringe can extend along a longitudinal axis between a proximal and a distal end. The cannulated syringe can have an inner tube and an outer tube that are interconnected at the distal end as a single fixed unit. A first cannulation can be formed along the longitudinal axis of the cannulated syringe within the inner tube and a second cannulation can be formed within an annular space between the inner and outer tubes. The outer tube can define an opening through a sidewall thereof. The cannulated syringe can be closed from fluid communication between the inner and outer tubes.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: December 9, 2014
    Assignee: Biomet Manufacturing, LLC
    Inventor: Mark V. Vandewalle