Means For Intermixing Liquid With Solid Or Different Liquid Patents (Class 604/82)
  • Patent number: 12017030
    Abstract: A hydrogen-enhanced drug delivery system for hydrogen-assisted transdermal delivery of a therapeutic agent is provided. The system includes a hydrogen-generating compartment comprising at least one dry chemical. Addition of an activator, such as a liquid composition, from within or outside of the system, causes the dry chemical(s) to generate molecular hydrogen (H2) within the system. The molecular hydrogen passes through a skin-contacting surface of the system, which is permeable to hydrogen and not permeable to the dry chemical(s) and the liquid composition, and enhances the release of the therapeutic agent from the system as H2 is delivered to the subject's body. The H2 can also enhance the therapeutic effect of the therapeutic agent.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: June 25, 2024
    Assignee: H2 Universe, LLC
    Inventors: Marina Yu. Safonov, Christian S. Yorgure, Vladimir L. Safonov
  • Patent number: 12005472
    Abstract: A manifold having a first side, a second side, a first channel extending from the first side to the second side, and a second channel extending from the first side to the second side is disclosed. The first channel and the second channel each define a linear longitudinal axis. In one embodiment, the first channel longitudinal axis and the second channel longitudinal axis are oblique to the first side and the second side of the manifold. The manifold of the present disclosure provides channels that can be easily cleaned and allow for an increased flow performance.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: June 11, 2024
    Assignee: Rooftop Research, LLC
    Inventor: Robert S. Burns
  • Patent number: 12005238
    Abstract: A syringe assembly and methods of producing the syringe assembly are described. The syringe assembly may include a syringe body, a plunger rod, a barrel cover, and a tamper evident device. The syringe body has a chamber configured to receive a material. The plunger rod moves within the chamber to dispense the material. The barrel cover covers the syringe body. The backstop is attached to the barrel cover to prevent a portion of the plunger rod from moving proximally through the backstop. The tamper evident device includes a tamper evident cap covering a distal portion of the syringe body, a collar attached to the barrel cover, and a frangible connection between the tamper evident cap and the collar.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: June 11, 2024
    Assignee: FRESENIUS KABI USA, LLC
    Inventor: Christopher J. Murray
  • Patent number: 12002288
    Abstract: There is provided a recognition system adaptable to a portable device or a wearable device. The recognition system senses a body heat using a thermal sensor, and performs functions such as the living body recognition, image denoising and body temperature prompting according to detected results.
    Type: Grant
    Filed: April 10, 2023
    Date of Patent: June 4, 2024
    Inventors: Nien-Tse Chen, Yi-Hsien Ko, Yen-Min Chang
  • Patent number: 11986175
    Abstract: A medical system includes a propellant source containing a propellant fluid, containers containing a material, and a shaft having a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft. The plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, and a first lumen surrounds, is coaxial with, or is side-by-side with, at least one other lumen.
    Type: Grant
    Filed: November 11, 2020
    Date of Patent: May 21, 2024
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Gerald Fredrickson, Jennifer Whelehan, Matthew Laplaca, Lauren Lydecker
  • Patent number: 11981494
    Abstract: A transfer cannula for sterile transfer of fluids to powders or fluids to fluids from a first receptacle into a second receptacle has two tube sections running in the same direction which have different lengths in the longitudinal direction of the tube sections, the longer tube section terminating in an insertion tip. The tube sections are rigidly connected to a coupling wall surrounding the tube sections in a cylindrical manner. The coupling wall has a cutout which extends as far as an end edge of the coupling wall and in which, when viewed from the side, an insertion tip of each tube section is exposed. The coupling wall projects beyond the insertion tip in the direction of the longitudinal extent of the tube sections, and the cut-out widens in a corresponding V-shape at the end edge.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: May 14, 2024
    Assignee: RPC Formatec GmbH
    Inventors: Johannes Krieger, Markus Thau
  • Patent number: 11975113
    Abstract: A wound dressing material includes a particle having a crosslinked gelatin derivative, the gelatin derivative having the structure represented by the following formula (1): GltnNH—CHR1R2??(1) wherein “Gltn” represents a gelatin residue, R1 represents an alkyl group having 1-17 carbon atoms, and R2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and the particle having a particle size ranging from 1 to 1,000 ?m.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: May 7, 2024
    Assignee: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Tetsushi Taguchi, Akihiro Nishiguchi
  • Patent number: 11957848
    Abstract: A method of making magnetically controllable devices for interventional medical procedures comprises the steps of: Manufacturing a medical device for interventional medical procedures having magnetic materials which are without permanent magnetization; and establishing permanent magnetization within the magnetic materials subsequent to manufacturing, wherein the permanent magnetization allows the medical device to be magnetically controllable. The method may further including the step of packaging and sterilizing the medical device, wherein establishing permanent magnetization occurs after packaging and sterilization. The establishing permanent magnetization within the magnetic materials may include providing different magnetic orientations to distinct portions of the magnetic materials. The magnetic material includes one of a platinum alloy or a palladium alloy.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: April 16, 2024
    Assignee: UNandUP, LLC
    Inventor: Francis M. Creighton
  • Patent number: 11951279
    Abstract: A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveable by the actuator once the cartridge is inserted into the drive unit.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: April 9, 2024
    Assignee: MannKind Corporation
    Inventor: Christopher C. Gregory
  • Patent number: 11918629
    Abstract: Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 5, 2024
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Israel Nur, Elena Grimberg, Itai Podoler, Inbar Gahali-Sass, Erez Ilan, Ronen Eavri
  • Patent number: 11904124
    Abstract: A hydrogen-delivering system for topical application of molecular hydrogen is provided. The system includes a housing that comprises at least one dry chemical and a liquid composition sealed therein, and that is configured to be attached to a target area of a subject's skin. The dry chemical and the aqueous composition are separated within the housing until the system is activated and the dry chemical and the aqueous composition are mixed to generate molecular hydrogen. The molecular hydrogen passes through a skin-facing surface of the housing, which is permeable to hydrogen and not permeable to the dry chemical and the aqueous composition, and is delivered to the subject's body.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: February 20, 2024
    Assignee: H2 Universe, LLC.
    Inventor: Vladimir L. Safonov
  • Patent number: 11883363
    Abstract: A reconstitution device includes a body, a first piercing member located at a first end of the body, and a receptacle located at the second end of the body. The receptacle includes a collar configured to engage a vial, and a cap extending from the collar and holding a second piercing member. The second piercing member is disposed within the collar. The reconstitution device includes a first fluid pathway formed within and extending from the first piercing member to the second piercing member. The reconstitution device includes a second fluid pathway formed within and extending from the second piercing member to a portion of the body between the first piercing member and the second piercing member.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: January 30, 2024
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Freddy Desbrosses, Pierpaolo Padula, Marjorie Desriaux, Yannis Abdessalem, Diego Santo-Domingo Porqueras
  • Patent number: 11883818
    Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: January 30, 2024
    Assignees: bioMerieux, Inc., BioFire Defense, LLC
    Inventors: Kirk Ririe, Christopher S. Ronsick, Mark S. Wilson, John D. Walsh, Ryan T. Hill
  • Patent number: 11872373
    Abstract: A dual fluid injection device is provided that includes at least two syringes. A hub is provided, to which a first syringe and a second syringe are simultaneously connected. The hub includes a fluid delivery member at an end thereof for injection at a site. The first syringe and the second syringe are actuated independently at a directional control valve.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: January 16, 2024
    Assignee: Medone Surgical, Inc.
    Inventors: Bruce Beckstein, Segundo Rodriguez, Erik S Brown
  • Patent number: 11865076
    Abstract: A closed transfer system for transferring metered dose of a beneficial agent from a flexible primary container to a second reservoir or to a patient. The system can be configured to transfer multiple doses.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: January 9, 2024
    Assignee: Aktivax, Inc.
    Inventor: Amir Genosar
  • Patent number: 11857498
    Abstract: A medication component mixing system is formed of a first syringe, such as a female syringe, and a second syringe such as a male syringe, wherein the system is configured to mix a female portion and a male portion of the medication. The female syringe and the male syringe mechanically couple to one another in an end-to-end fashion for mixing of the contents of the female and male portions.
    Type: Grant
    Filed: September 19, 2022
    Date of Patent: January 2, 2024
    Assignee: Indivior UK Limited
    Inventors: Andrew Watkins, Qi Li, Richard L. Norton, Daniel Barnhill, Trant Holt
  • Patent number: 11839747
    Abstract: A nested syringe comprising: a first chamber comprising: an inner tube extending from a base of the first chamber and defining a base opening in the base; an adapter tube in fluid communication with the inner tube via the base opening; at least one base port in the base for providing fluid communication between the adaptor tube and a first inner volume of the first chamber; a second chamber, adapted for insertion into the first chamber wherein the second chamber comprises a third port adapted to provide fluid communication between the inner tube and a second inner volume of the second chamber and adapted for preventing fluid communication between the first inner volume and the second inner volume when the second chamber is inserted into the first chamber and the inner tube penetrates the third port; and a plunger, wherein the plunger is adapted for insertion into the second chamber.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: December 12, 2023
    Inventor: Fares Srouji
  • Patent number: 11819665
    Abstract: A prefilled syringe includes a barrel body, a gasket that seals a proximal end side of a medicine chamber of the barrel body, and a cap that is attached to a tip and seals a distal end side of the medicine chamber. The cap includes a surface area increasing member that extends to the proximal end side, is inserted into a flow path of the tip, and protrudes to the medicine chamber to increase a surface area of a medicine solidified in a lump in the medicine chamber.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: November 21, 2023
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hitoshi Okihara, Fumiya Matsumoto
  • Patent number: 11813438
    Abstract: The invention relates to a disposable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: November 14, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: David Aubrey Plumptre
  • Patent number: 11813581
    Abstract: A method and an adapter for improving the efficiency of a static mixer being used to mix reactive fluids such as epoxy adhesives. This allows either a small static mixer to be employed, or a smaller purge flow during dispensing operations.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: November 14, 2023
    Assignee: 3M Innovative Properties Company
    Inventors: Patrick R. Connelly, Marc A. Egeland, Gregory P. Moriarty
  • Patent number: 11797797
    Abstract: The aerosol-generating article for use with an aerosol-generating device, the aerosol-generating article comprises an aerosol-forming substrate, and a surface area comprising a three dimensional code. The invention also relates to an aerosol-generating system comprising an aerosol-generating device and an aerosol-generating article.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: October 24, 2023
    Assignee: Philip Morris Products S.A.
    Inventors: Dionisius Florack, Evan Jochnowitz
  • Patent number: 11786662
    Abstract: An autoinjector is described that includes an outer body, a first trigger, an output needle, and a first compartment. The first compartment is positioned within the outer body and includes (i) a main body, (ii) a first biasing member coupled to the first trigger, and (iii) a protrusion positioned at a distal end of the main body. The autoinjector further includes a second compartment positioned in the outer body and in fluid communication with the first compartment and the output needle. The autoinjector also includes a second biasing member coupled to a second trigger. The first biasing member is configured to, upon application of force to the first trigger, automatically move an ampule in a distal direction relative to the main body to force the ampule against the protrusion, so as to break the ampule and allow a medicament to flow from the ampule to the second compartment.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: October 17, 2023
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Keith Chan, Ben Carney, Zachary Chen, Ha Seung Chung, Jazmine Saito, Wealth Mele Salvador, Shawn Swanson
  • Patent number: 11752258
    Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: September 12, 2023
    Assignee: AMGEN INC.
    Inventors: Yasaman Damestani, Lawrence S. Ring
  • Patent number: 11738126
    Abstract: The present invention relates to a concentrate container having a concentrate that is configured to form a dialysis solution after its dilution with a diluting agent, in particular with water, wherein the concentrate container is in communication with a first connector having a first code that contains at least one piece of information on the concentrate; and wherein the concentrate container is furthermore in communication with a second connector whose second code differs from the first code, with the second code containing at least one piece of information on the dialysis solution.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 29, 2023
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Frank Hedmann, Nadja Schubert
  • Patent number: 11712347
    Abstract: A medical compound preparation and delivery system, including a delivery device, the device including a depressible trigger operably coupled to move a plunger; a cartridge releasably coupled to the delivery device, the cartridge defining a lumen therethrough to receive at least a portion of the plunger therein; a receptacle defining a cavity therein for receiving a medical compound; a first tube slidably positionable within the cavity of the receptacle; and a second tube slidably positionable within the first tube, wherein the cartridge is slidably positionable within the second tube.
    Type: Grant
    Filed: February 13, 2021
    Date of Patent: August 1, 2023
    Inventor: James Scott Hay
  • Patent number: 11697128
    Abstract: Handheld gas spray systems for mixing and dispensing multi-component compositions.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: July 11, 2023
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Spencer Scott Paris, Evan Joseph Mosley, Nikhil Mankar
  • Patent number: 11679206
    Abstract: An injection system includes a handle assembly with a handle body having an outer surface surrounding a handle body interior and a plunger extending therethrough. A tubular handle collar is telescopically received in the handle body exterior and is axially movable with respect to the handle body. A syringe housing assembly is selectively connectable to the handle assembly and includes a syringe housing and a tubular syringe sleeve telescopically received through a distal end of the syringe housing and axially movable with respect thereto. The syringe housing has an exterior side surface surrounding a syringe housing interior configured to receive at least a portion of a syringe. The syringe sleeve has a proximal end, a distal end with a skin contact surface, and a generally cylindrically-shaped outer surface.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: June 20, 2023
    Assignee: West Pharmaceutical Services, Inc.
    Inventors: Kevin Stevens, Ian Scrimgeour, Scott Salter, Andrew Blair, Alan Kitching, David Sheperd
  • Patent number: 11657731
    Abstract: A device for training users in a proper mixing of pharmaceutical components, or for aiding in the mixing, or for performing the mixing, and administration of pharmaceutical components is disclosed. The device comprises a housing for receiving a pharmaceutical delivery device containing the pharmaceutical components. There is also a microcontroller disposed in the housing and a motion/orientation detection device disposed within or on the housing and in communication with the microcontroller. A method for use of the device is also disclosed, along with a substance for use as one of the pharmaceutical components.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: May 23, 2023
    Assignee: Janssen Pharmaceutica NV
    Inventors: Peter A. Krulevitch, Ian Scrimgeour, Scott Martin, James McLusky, James Glencross, Blair Hutton, Nick Foley, Jose Antonio Buron Vidal
  • Patent number: 11596780
    Abstract: Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: March 7, 2023
    Assignee: The Johns Hopkins University
    Inventors: Colin Cook, Warren Grayson
  • Patent number: 11590292
    Abstract: Apparatuses and methods for delivering a fluid, including a viscous fluid. These apparatuses may include a fluid reservoir, two or more piston chambers, a manifold, a delivery port, and a drive assembly and may be configured to inject either a predetermined amount of fluid or a continuous stream of fluid. These apparatuses may also be configured to switch between filling, injection and aspiration modes. These apparatuses may generally be hand-held and lightweight and may provide a significant mechanical advantage to the user.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: February 28, 2023
    Assignee: VeloJect, LLC
    Inventors: Robert E. Mayle, Jr., Erik J. Shahoian, Terrence C. Smith, Alexander Jasso
  • Patent number: 11583573
    Abstract: Disclosed herein is an anti-adhesion kit comprised of: (i) a fibrinogen solution component comprising: fibrinogen at a concentration of about 5 to 25 mg/ml; and free calcium ions at a concentration ranging from 0.1 ?M to 1 mM; and (ii) a thrombin component containing thrombin. Further disclosed is an anti-adhesion kit comprised of: (i) a fibrinogen solution component containing fibrinogen at a concentration of 8% to 25% of total protein by weight, and optionally free calcium ions at a concentration ranging from 0.1 ?M to 1 mM; wherein a total protein concentration ranges from about 80 to 120 mg/ml; and (ii) a thrombin component containing thrombin. Methods of using the kits e.g., to provide anti-adhesion curable compositions are also disclosed.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: February 21, 2023
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Inbar Gahali-Sass, Israel Nur, Erez Ilan, Ronen Eavri
  • Patent number: 11571360
    Abstract: A disposable transfer device has an injection device support surface for receiving an on-body injection device thereon and a flow path arrangement for transfer of fluid into the injection device, the transfer device being configured to define preferential gripping areas for user gripping of an injection device when such device is located on the support surface and interfering areas for interfering with user gripping of the injection device in the interfering areas.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: February 7, 2023
    Assignee: Enable Injections, Inc.
    Inventors: Dylan Bourelle, Matthew J. Huddleston, Joetta Renee Palmer, David Stefanchik
  • Patent number: 11565055
    Abstract: Apparatuses and methods for delivering a fluid, including a viscous fluid. These apparatuses may include a fluid reservoir, two or more piston chambers, a manifold, a delivery port, and a drive assembly and may be configured to inject either a predetermined amount of fluid or a continuous stream of fluid. These apparatuses may also be configured to switch between filling, injection and aspiration modes. These apparatuses may generally be hand-held and lightweight and may provide a significant mechanical advantage to the user.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: January 31, 2023
    Assignee: Veloject, LLC
    Inventors: Robert E. Mayle, Jr., Erik J. Shahoian, Terrence C. Smith, Alexander Jasso
  • Patent number: 11559467
    Abstract: In some embodiments, a medical fluid connector is configured to receive an emitter of therapeutic agents to be emitted into a fluid pathway within the connector, the medical fluid connector comprising a proximal female end, an intermediate region, a distal male end, and a fluid pathway extending from the proximal female end, through the intermediate region, to the distal male end. A retaining structure is positioned within the intermediate region. The retaining structure is configured to securely receive an emitter of one or more therapeutic agents in a position and orientation where the fluid pathway is configured to convey fluid moving longitudinally through the fluid pathway directly into a proximal region of the emitter, around one or more lateral surfaces of the emitter, and toward the distal male end.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: January 24, 2023
    Assignee: ICU Medical, Inc.
    Inventor: Thomas F. Fangrow
  • Patent number: 11540976
    Abstract: A vial adapter for reconstituting a drug and drawing a drug from a vial. The vial adapter includes a passageway for passage of a diluent into the vial to mix with and reconstitute the drug and a chamber containing the reconstituted drug drawn from the vial. A vacuum is applied through the adapter to draw the reconstituted drug from the vial. The reconstituted drug can be accessed in one or two ways, either via a luer locked syringe or via a needled syringe.
    Type: Grant
    Filed: February 22, 2020
    Date of Patent: January 3, 2023
    Assignee: SKIN NY DERMATOLOGY, PLLC
    Inventors: Rita V. Linkner, Marc-Alan Levine
  • Patent number: 11534111
    Abstract: The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 27, 2022
    Assignee: I-SENS, INC.
    Inventors: Kyung Chul Chae, Hyun Ho Choi, Goang Yel Ryu, Ji Hoon Wang, Young Jea Kang
  • Patent number: 11524124
    Abstract: A drug delivery device comprises a medication container containing medication for delivery and a detachable unit having an electronic circuit with a microprocessor. The electronic circuit is open and non-operational when the detachable component is assembled on the drug delivery device; and the electronic circuit is closed and operational when the detachable component is detached from the drug delivery device. The detachment of the detachable unit is an essential step to operate the drug delivery device. The detachable unit can be an activation protection cap or a needle shield remover for an autoinjector device. Alternatively, the detachable unit can be a needle shield remover for a pre-filled syringe.
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: December 13, 2022
    Inventor: Min Wei
  • Patent number: 11504485
    Abstract: Cellular therapy infusion devices for the delivery of media including cellular therapies to a patient's tissue, cells, and/or blood include a barrel, a plunger that fits within the barrel, a syringe shaft, and a pressure relief system configured to achieve and/or maintain a desired level of pressure and/or force within the device so that cellular behavior and/or viability is not adversely impacted by the mechanical forces exerted thereon via depressing the plunger into the barrel so the cellular therapy media may be pushed from the barrel into a patient delivery device for administration to the patient. The cellular therapy infusion devices may cooperate with and/or fit into cellular therapy infusion systems designed to create and/or maintain preferred conditions for the cellular therapy media stored in the barrel and automatically administer the cellular therapy media from the cellular therapy infusion device to the patient in a steady, regulated, and/or preferred manner.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: November 22, 2022
    Assignee: CELLULAR VEHICLES, INC.
    Inventors: Nikhil Joshi, Marcus Foley, Avnesh Thakor
  • Patent number: 11478584
    Abstract: A syringe includes a syringe body, a first plunger, a second plunger, and an inner tube. The syringe body defines a syringe port in fluid communication with a syringe cavity. The first plunger is disposed within the syringe cavity and defines a first chamber in the syringe cavity, wherein the first chamber is in fluid communication with the syringe port. The second plunger is disposed within the syringe cavity, the first plunger and the second plunger cooperatively defining a second chamber in the syringe cavity. The inner tube comprises an inner tube lumen, wherein the inner tube and a first plunger shaft lumen of a first plunger shaft define an annulus therebetween, the annulus in fluid communication with a first plunger channel of the first plunger and the annulus permits fluid communication between the syringe port and the first plunger channel.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: October 25, 2022
    Assignee: CAREFUSION 303, INC.
    Inventors: Todd Oda, George Mansour, Eugene Mason
  • Patent number: 11452438
    Abstract: An endoscope includes: a long member that is connected to a direction changing portion provided in an insertion portion and enables the direction changing portion to move; a sliding member that includes a first contact portion that is brought into contact with an inner surface of a guide tube that allows insertion of the long member and a second contact portion that is brought into contact with the inner surface of the guide tube; a flow path that includes an opening portion formed in a direction that intersects a longitudinal axis of the sliding member such that a fluid flows into a clearance between the guide tube and the sliding member; and an operation member that causes the sliding member to move forward and backward relative to the guide tube.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: September 27, 2022
    Assignee: OLYMPUS CORPORATION
    Inventors: Yoshiaki Ito, Hidetada Sueyasu
  • Patent number: 11439761
    Abstract: A method of preparing a syringe in connection with a therapeutic treatment is disclosed. The method can include removing a plunger of the syringe from a barrel of the syringe, aligning the barrel in a horizontal orientation, filling a lumen of the barrel with a viscous material through an opening at a proximal end of the barrel, and inserting a plunger tip into the lumen to seal the lumen. The method can also include attaching an implantation device to a hub coupled to the barrel at a distal end of the barrel. The method can also include depressing the plunger until the cell suspension fills the implantation device and a droplet of the cell suspension is expelled from a distal tip of the implantation device.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: September 13, 2022
    Assignee: SanBio, Inc.
    Inventor: Michael McGrogan
  • Patent number: 11426522
    Abstract: The present invention relates to an assembly comprising an injection device comprising a container for a product, wherein the container includes a distal tip encompassing a channel providing a passageway for transferring the product, and an adaptor mounted onto the distal tip. The assembly further includes a heat-shrinkable film covering at least part of the container and at least part of the adaptor, wherein the heat-shrinkable film maintains the adaptor blocked in rotation and in translation relative to the container when the heat-shrinkable film is in heat-shrunk condition.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: August 30, 2022
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Cedric Foucher, Lionel Lefebvre, Michel Vernizeau
  • Patent number: 11400207
    Abstract: A device includes a syringe having a barrel and a syringe tip; an aerator having (i) a generally cylindrical exterior body; (ii) an inlet end; (iii) an outlet end; (iv) a tapered outlet port at its outlet end; and (v) an interior cavity comprising (A) an input port section, (B) a converging section, (C) a throat section, (D) a diverging section, (E) an outlet section, (F) a first vent that fluidly couples at least one of the throat section or the diverging section to an area outside and adjacent to the exterior body, and (G) a second vent that fluidly couples the outlet section to the area; and a housing that (x) circumferentially surrounds an end of the barrel and the aerator, (z) has an interior surface, (aa) forms a circumferential gas pocket between the interior surface and the exterior body, and (bb) has a housing discharge tip.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: August 2, 2022
    Assignee: Agitated Solutions Inc.
    Inventors: Benjamin Arcand, Carl Lance Boling
  • Patent number: 11383231
    Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: July 12, 2022
    Assignees: bioMerieux, Inc., BioFire Defense, LLC
    Inventors: Kirk Ririe, Christopher S. Ronsick, Mark S. Wilson, John D. Walsh, Ryan T. Hill
  • Patent number: 11376358
    Abstract: A packaging for storing a drug delivery device comprising a container provided at its distal end with a distal tip bearing a needle, the needle being covered by a shield, the packaging comprising: a support comprising: a first holding element configured for receiving at least part of the shield before use, a second holding element configured for receiving a distal part of the needle after use, and an envelope for receiving the drug delivery device, the envelope being closed by the support.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: July 5, 2022
    Assignee: Becton Dickinson France
    Inventors: Frédéric Perot, Julien Gagliano, Marie-Liesse Le Corfec, Hervé Monchoix
  • Patent number: 11318484
    Abstract: A nozzle includes a mounting opening that is to be connected to an opening portion of a container, an outlet that jets liquid stored in the container, a side face that connects the mounting opening to the outlet, and a liquid storage portion that stores a part of the liquid stored in the container in the nozzle without jetting a part of the liquid from the outlet in a case where the liquid is to be jetted from the dispensing container, that is, in a case where the outlet faces downward in the direction of gravity.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: May 3, 2022
    Assignee: FUJIFILM Corporation
    Inventors: Atsuhiko Wada, Keiji Shigesada, Junichi Katada
  • Patent number: 11278667
    Abstract: A medicament delivery device may comprise a medicament chamber configured to hold a medicament, a plunger configured to move relative to the medicament chamber to expel the medicament from the medicament chamber, a pin configured to move from a first pin position wherein the pin prevents movement of the plunger to a second pin position wherein the pin allows movement of the plunger, an actuation assembly configured to move the pin from the first pin position to the second pin position, and a needle coupled to the medicament chamber. The medicament may flow through the needle from the medicament chamber to a user. The actuation assembly may be configured to automatically move the pin after a predetermined time delay.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: March 22, 2022
    Assignee: ZEALAND PHARMA A/S
    Inventors: Christopher Gregory, Geoffrey Jenkins
  • Patent number: 11166875
    Abstract: Compositions and methods for separating a sample of whole blood or bone marrow aspirate into a fraction rich in at least one of platelets and pluripotent cells are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the PRP fraction and the at least one other fraction. Preferably, centrifugation is completed without substantial activation of platelets. Optionally, the separator substance could be hardened to form a solid barrier that allows removal of all or substantially all of the platelets in the PRP fraction without remixing of the PRP fraction with the at least one other fraction. Transfer devices and methods are also provided in which a sterile sample can be transferred from a separation/preparation container (e.g., vacutainer) to a consumer or other container (e.g., dropper) while maintaining sterility of the sample.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 9, 2021
    Assignee: The Regents of The University of California
    Inventor: Jane F. Emerson
  • Patent number: 11123489
    Abstract: A medicament delivery device is presented having a second housing part, a plunger rod arranged in the second housing part and configured to act on a stopper arranged inside a multi-chamber container. A first housing part contains the multi-chamber container, where the first housing part is arranged to be manually displaced into the second housing part by relative rotation between the first and the second housing parts for mixing at least two substances arranged inside the multi-chamber container. The delivery device further has a rotating contact element arranged between said plunger rod and said stopper capable of rotating in relation to said plunger rod.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: September 21, 2021
    Assignee: SHL MEDICAL AG
    Inventors: Gunnar Elmén, Sebastian Karlsson
  • Patent number: 11027062
    Abstract: A liquid transfer device is described. The liquid transfer device comprising a vial adapter comprising a puncturing cannula for puncturing an injection vial stopper, an IV spike and a substitute IV port holder for receiving a substitute IV port, and a flow control member port. The IV spike, the substitute IV port holder and the puncturing cannula are in flow communication with the flow control member port. The liquid transfer device comprising a flow control member sealingly inserted in the flow control member port. Rotation of the flow control member between a plurality of positions controls flow communication of the liquid transfer device, the positions comprising a mixing position for enabling flow communication between the IV spike and the puncturing cannula; and an administering position for enabling flow communication between the IV spike and the substitute IV port holder.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: June 8, 2021
    Assignee: WEST PHARMA. SERVICES IL, LTD.
    Inventors: Elisheva Fabrikant, Igor Denenburg, Amir Lev, Uri David