Abstract: Systems, devices, and methods for delivering a therapeutic or other agent to a breastfeeding child are disclosed herein. A delivery system of the systems can include, for example, a wearable device configured to be positioned on a breast during breastfeeding. The delivery system can further include an agent source configured to house the therapeutic or other agent and a fluid source configured to supply a supplemental fluid. The agent source and the fluid source can be fluidly coupled to the wearable device via a connector. When the device is positioned on the breast and the breastfeeding child is breastfeeding, the supplemental fluid mixes with the therapeutic or other agent and flows through the connector into the wearable device and into a mouth of the breastfeeding child.

Abstract: A medicine liquid transfer device includes a double-chamber syringe, a dispensing needle assembly, and a syringe needle sealing assembly. The medicine liquid transfer device features an exquisite structural design and easy assembly, enables fully-closed medicine preparation and transfer, and allows automatic or manual adjustment and balance of the air pressure inside the medicine container in use, thereby minimizing the risk of medicine leakage and providing an excellent leakproof effect, while having advantages of low cost, high convenience of use, and the like.

Abstract: Systems and methods are described that utilize bioprinters to form scaffold structures in situ to facilitate treatment of the musculoskeletal or skin disorders in patients. A method for treating a musculoskeletal disorder of a patient includes positioning a bioprinter at a situs of the musculoskeletal disorder, or a situs of a skin injury, in the patient. The method includes extruding a hydrogel formulation from the bioprinter into the situs. The method includes curing the hydrogel formulation in the situs. The hydrogel formulation has a composition effective to generate, upon the curing, a scaffold structure in the situs to facilitate muscle hypertrophy and/or new muscle fibers, or skin wound healing, in the situs.

Abstract: An anchor system with a bridle substrate and harness configured to attach to an anchor line. An outer bladder surrounds an inner bladder for coupling on top of the bridle substrate. Water enters the anchor system through a water inlet that feeds directly to the inner bladder and fills that first. Water then overflows from the inner bladder to the outer bladder to fill that second. The inner bladder provides stability and is positioned with a majority of its volume closer to an uphill end of the anchor bladder while the outer bladder is positioned with a majority of its volume closer to a downhill end of the anchor bladder. Reinforcement connectors for each bladder resist deformation of the bladders to resist movement of the anchor bladder while filling.

Abstract: Provided herein are compositions and kits including trichloroacetic acid, and methods of using the same for debridement during endodontic treatment.

Abstract: A storage bag (100) includes a main tube (102) extending from a first end to a second end and defining a first inner surface and outer surface. The main tube includes a first angled edge (128) and a second angled edge (132) extending from the first end of the main tube and forming a first angled interface. The storage bag also includes a port tube (104) extending from a first end to a second end and defining a second inner surface and outer surface. The second end of the port tube includes a third angled edge and a fourth angled edge extending from the second end of the port tube, forming a second angled interface. The second angled interface of the port tube is positioned over the first angled interface of the main tube. A portion of the port tube not overlapping the main tube is sealed to itself to form an angled drainage area (182).

Abstract: The present disclosure relates to a system and to a method for measuring Brix of a liquid such as sap, syrup or taffy. The system for measuring Brix of a liquid comprises: a tank for receiving a volume of the liquid; a temperature reading apparatus for measuring a temperature of the liquid; a weighing apparatus for measuring a weight of the volume of liquid received in the tank; a volume measurement system for measuring the volume of the liquid received in the tank; and a computer operatively connected to the apparatuses and using the data received from the same to determine the Brix of the liquid. The method comprising providing the Brix measuring system; measuring the temperature, weight, volume of the liquid received in the tank, and determining the Brix measurement based on the data received and using the computer.

Abstract: Apparatuses and methods for continuous injection of fluid, in some examples the apparatuses may include a manifold, a pair of reciprocating pistons, and an actuation control that may apply both suction (aspiration) and injection of fluid as part of the same actuation. The apparatuses and methods may be configured to simplify operation of a continuous fluid injection apparatus, including operations that include an aspiration an injection of fluid to confirm the absence/presence of blood prior to injection.

Abstract: An injector for injecting a medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, arid a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.

Abstract: A mixing and spraying assembly for a tissue sealant includes a mixing assembly, a spray tip assembly, and a malleable section having a proximal end connected with the mixing assembly and a distal end connected with the spray tip assembly for enabling the spray tip assembly to be angulated relative to the mixing assembly. The malleable section includes a flexible shaft having a length, a malleable wire conduit that extends along the length of the flexible shaft, and a malleable wire disposed in the malleable wire conduit. The malleable wire is longer than the flexible shaft and has a proximal end that is connected to the mixing assembly and a distal end that is connected to the spray tip assembly. First and second fluids are mixed within the mixing assembly to form a tissue sealant that is delivered through the malleable section for being expressed from the spray tip assembly.

Abstract: This disclosure relates generally to medical tubing assemblies and methods for fluid delivery from a single fluid reservoir. In one example, a tubing assembly may be configured to couple to an endoscope for distributing fluid between the endoscope and a fluid reservoir during an endoscopic procedure. The assembly may comprise a tubing manifold, a cap configured to be removably attached to the fluid reservoir, a portion of gas supply tubing and lens wash supply tubing in fluid communication between the manifold and the endoscope, a portion of gas supply tubing in fluid communication between the cap and the manifold, and a portion of lens wash supply tubing in fluid communication between the fluid reservoir and the manifold. Further examples may include portions of irrigation supply tubing and portions of alternate gas supply tubing selectively connectable in fluid communication between the manifold, fluid reservoir and endoscope.

Abstract: Drug delivery devices and related arrangements are disclosed. A drug delivery device may include a housing having an opening, a drug storage container including a delivery member with an insertion end configured to extend at least partially through the opening, and a plunger. A drive mechanism may be included for driving the plunger in a distal direction to expel a drug from the drug storage container through the delivery member upon activation. The drug delivery device may additionally include a guard moveably disposed adjacent to the opening and operably coupled to the drive mechanism for activation of the drive mechanism. A lock may be selectively engageable with the guard to limit movement of the guard in the proximal direction. An indicator may be coupled to the drive mechanism to generate an audible signal during drug delivery, and to cease generating the audible signal when drug delivery is complete.

Abstract: The present disclosure provides a biometrically controlled handheld medication dispensing device. The device includes a housing containing a cartridge carrier, designed with a specific connector to align with a medication cartridge. Notably, the device also includes a biometric authentication component that works in conjunction with an activator mechanism. When operated and upon user authentication, the activator mechanism causes the cartridge carrier to move the medication cartridge between a stored position and a dispensing position, where it can be compressed to safely and efficiently dispense medication to a user.

Abstract: Compositions and methods for sealing tissue of a patient in a wet environment are disclosed.

Abstract: A mixing and spraying assembly for a tissue sealant includes a mixing assembly, a spray tip assembly, and a malleable section having a proximal end connected with the mixing assembly and a distal end connected with the spray tip assembly for enabling the spray tip assembly to be angulated relative to the mixing assembly. The malleable section includes a flexible shaft having a length, a malleable wire conduit that extends along the length of the flexible shaft, and a malleable wire disposed in the malleable wire conduit. The malleable wire is longer than the flexible shaft and has a proximal end that is connected to the mixing assembly and a distal end that is connected to the spray tip assembly. First and second fluids are mixed within the mixing assembly to form a tissue sealant that is delivered through the malleable section for being expressed from the spray tip assembly.

Abstract: An injection device and an injection device trainer for training a user to use an injection device. Each one of the injection device and the injection device trainer can include: a body portion; and an actuator positioned towards a proximal end of the body portion, the actuator moveable from a proximal position to a distal position; wherein the body portion comprises a body protrusion and the actuator comprises a latch that is arranged to couple with the body protrusion when the actuator is in the distal position, thus holding the actuator in the distal position.

Abstract: The present disclosure provides a biometrically controlled handheld medication dispensing device. The device includes a housing containing a cartridge carrier, designed with a specific connector to align with a medication cartridge. Notably, the device also includes a biometric authentication component that works in conjunction with an activator mechanism. When operated and upon user authentication, the activator mechanism causes the cartridge carrier to move the medication cartridge between a stored position and a dispensing position, where it can be compressed to safely and efficiently dispense medication to a user.

Abstract: An adapter (650) for transferring fluid between a first device (100) and a second device (800). The adapter comprises a first end (652) for receiving the first device, wherein the first end includes a side wall for locating around the first device (100). The adapter (650) further comprises a second end (654) for engaging the first device (100), and including a retaining member (656; 658; 662), wherein the retaining member (656; 658; 662) is operable to prevent removal of the first device (100) from the adapter (650) upon engagement of the first device (100) with the second end (654). The first end (652) and the second end (654) are open on both ends to comprise a through-bore extending through the adapter (650). In some cases, the first device (100) may be a drug pen containing insulin.

Abstract: A hydrogen-enhanced drug delivery system for hydrogen-assisted transdermal delivery of a therapeutic agent is provided. The system includes a hydrogen-generating compartment comprising at least one dry chemical. Addition of an activator, such as a liquid composition, from within or outside of the system, causes the dry chemical(s) to generate molecular hydrogen (H2) within the system. The molecular hydrogen passes through a skin-contacting surface of the system, which is permeable to hydrogen and not permeable to the dry chemical(s) and the liquid composition, and enhances the release of the therapeutic agent from the system as H2 is delivered to the subject's body. The H2 can also enhance the therapeutic effect of the therapeutic agent.

Abstract: A manifold having a first side, a second side, a first channel extending from the first side to the second side, and a second channel extending from the first side to the second side is disclosed. The first channel and the second channel each define a linear longitudinal axis. In one embodiment, the first channel longitudinal axis and the second channel longitudinal axis are oblique to the first side and the second side of the manifold. The manifold of the present disclosure provides channels that can be easily cleaned and allow for an increased flow performance.

Abstract: A syringe assembly and methods of producing the syringe assembly are described. The syringe assembly may include a syringe body, a plunger rod, a barrel cover, and a tamper evident device. The syringe body has a chamber configured to receive a material. The plunger rod moves within the chamber to dispense the material. The barrel cover covers the syringe body. The backstop is attached to the barrel cover to prevent a portion of the plunger rod from moving proximally through the backstop. The tamper evident device includes a tamper evident cap covering a distal portion of the syringe body, a collar attached to the barrel cover, and a frangible connection between the tamper evident cap and the collar.

Abstract: There is provided a recognition system adaptable to a portable device or a wearable device. The recognition system senses a body heat using a thermal sensor, and performs functions such as the living body recognition, image denoising and body temperature prompting according to detected results.

Abstract: A medical system includes a propellant source containing a propellant fluid, containers containing a material, and a shaft having a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft. The plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, and a first lumen surrounds, is coaxial with, or is side-by-side with, at least one other lumen.

Abstract: A transfer cannula for sterile transfer of fluids to powders or fluids to fluids from a first receptacle into a second receptacle has two tube sections running in the same direction which have different lengths in the longitudinal direction of the tube sections, the longer tube section terminating in an insertion tip. The tube sections are rigidly connected to a coupling wall surrounding the tube sections in a cylindrical manner. The coupling wall has a cutout which extends as far as an end edge of the coupling wall and in which, when viewed from the side, an insertion tip of each tube section is exposed. The coupling wall projects beyond the insertion tip in the direction of the longitudinal extent of the tube sections, and the cut-out widens in a corresponding V-shape at the end edge.

Abstract: A wound dressing material includes a particle having a crosslinked gelatin derivative, the gelatin derivative having the structure represented by the following formula (1): GltnNH—CHR1R2??(1) wherein “Gltn” represents a gelatin residue, R1 represents an alkyl group having 1-17 carbon atoms, and R2 represents a hydrogen atom or an alkyl group having 1-17 carbon atoms, and the particle having a particle size ranging from 1 to 1,000 ?m.

Abstract: A method of making magnetically controllable devices for interventional medical procedures comprises the steps of: Manufacturing a medical device for interventional medical procedures having magnetic materials which are without permanent magnetization; and establishing permanent magnetization within the magnetic materials subsequent to manufacturing, wherein the permanent magnetization allows the medical device to be magnetically controllable. The method may further including the step of packaging and sterilizing the medical device, wherein establishing permanent magnetization occurs after packaging and sterilization. The establishing permanent magnetization within the magnetic materials may include providing different magnetic orientations to distinct portions of the magnetic materials. The magnetic material includes one of a platinum alloy or a palladium alloy.

Abstract: A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveable by the actuator once the cartridge is inserted into the drive unit.

Abstract: Provided herein are kits comprised of a first container including a solution of fibrinogen-containing component that includes fibrinogen at a concentration range of about 5 mg/ml to about 30 mg/ml, and having a total protein concentration range of about 15 mg/ml to about 40 mg/ml; and a second container that includes a solution of thrombin-containing component. Further provided are mixtures comprised of fibrinogen and thrombin, calcium ions, and albumin, the mixture being comprised of total protein in a range of about 2.5 mg/ml to about 30 mg/ml, fibrinogen in a range of about 50% to about 80% of total protein, and albumin in a range of more than 0.65 mg/ml to about 3 mg/ml. Further provided herein are methods for preventing or reducing tissue adhesion, and hydrogel materials made of fibrin.

Abstract: A hydrogen-delivering system for topical application of molecular hydrogen is provided. The system includes a housing that comprises at least one dry chemical and a liquid composition sealed therein, and that is configured to be attached to a target area of a subject's skin. The dry chemical and the aqueous composition are separated within the housing until the system is activated and the dry chemical and the aqueous composition are mixed to generate molecular hydrogen. The molecular hydrogen passes through a skin-facing surface of the housing, which is permeable to hydrogen and not permeable to the dry chemical and the aqueous composition, and is delivered to the subject's body.

Abstract: A reconstitution device includes a body, a first piercing member located at a first end of the body, and a receptacle located at the second end of the body. The receptacle includes a collar configured to engage a vial, and a cap extending from the collar and holding a second piercing member. The second piercing member is disposed within the collar. The reconstitution device includes a first fluid pathway formed within and extending from the first piercing member to the second piercing member. The reconstitution device includes a second fluid pathway formed within and extending from the second piercing member to a portion of the body between the first piercing member and the second piercing member.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: A dual fluid injection device is provided that includes at least two syringes. A hub is provided, to which a first syringe and a second syringe are simultaneously connected. The hub includes a fluid delivery member at an end thereof for injection at a site. The first syringe and the second syringe are actuated independently at a directional control valve.

Abstract: A closed transfer system for transferring metered dose of a beneficial agent from a flexible primary container to a second reservoir or to a patient. The system can be configured to transfer multiple doses.

Abstract: A medication component mixing system is formed of a first syringe, such as a female syringe, and a second syringe such as a male syringe, wherein the system is configured to mix a female portion and a male portion of the medication. The female syringe and the male syringe mechanically couple to one another in an end-to-end fashion for mixing of the contents of the female and male portions.

Abstract: A nested syringe comprising: a first chamber comprising: an inner tube extending from a base of the first chamber and defining a base opening in the base; an adapter tube in fluid communication with the inner tube via the base opening; at least one base port in the base for providing fluid communication between the adaptor tube and a first inner volume of the first chamber; a second chamber, adapted for insertion into the first chamber wherein the second chamber comprises a third port adapted to provide fluid communication between the inner tube and a second inner volume of the second chamber and adapted for preventing fluid communication between the first inner volume and the second inner volume when the second chamber is inserted into the first chamber and the inner tube penetrates the third port; and a plunger, wherein the plunger is adapted for insertion into the second chamber.

Abstract: A prefilled syringe includes a barrel body, a gasket that seals a proximal end side of a medicine chamber of the barrel body, and a cap that is attached to a tip and seals a distal end side of the medicine chamber. The cap includes a surface area increasing member that extends to the proximal end side, is inserted into a flow path of the tip, and protrudes to the medicine chamber to increase a surface area of a medicine solidified in a lump in the medicine chamber.

Abstract: A method and an adapter for improving the efficiency of a static mixer being used to mix reactive fluids such as epoxy adhesives. This allows either a small static mixer to be employed, or a smaller purge flow during dispensing operations.

Abstract: The invention relates to a disposable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a cartridge holder for retaining a cartridge containing the medicament, a piston rod displaceable relative to the cartridge holder, a driver coupled to the piston rod, a display member for indicating a set dose and being coupled to the housing and to the driver, and a button coupled to the display member and to the driver.

Abstract: The aerosol-generating article for use with an aerosol-generating device, the aerosol-generating article comprises an aerosol-forming substrate, and a surface area comprising a three dimensional code. The invention also relates to an aerosol-generating system comprising an aerosol-generating device and an aerosol-generating article.

Abstract: An autoinjector is described that includes an outer body, a first trigger, an output needle, and a first compartment. The first compartment is positioned within the outer body and includes (i) a main body, (ii) a first biasing member coupled to the first trigger, and (iii) a protrusion positioned at a distal end of the main body. The autoinjector further includes a second compartment positioned in the outer body and in fluid communication with the first compartment and the output needle. The autoinjector also includes a second biasing member coupled to a second trigger. The first biasing member is configured to, upon application of force to the first trigger, automatically move an ampule in a distal direction relative to the main body to force the ampule against the protrusion, so as to break the ampule and allow a medicament to flow from the ampule to the second compartment.

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

Abstract: The present invention relates to a concentrate container having a concentrate that is configured to form a dialysis solution after its dilution with a diluting agent, in particular with water, wherein the concentrate container is in communication with a first connector having a first code that contains at least one piece of information on the concentrate; and wherein the concentrate container is furthermore in communication with a second connector whose second code differs from the first code, with the second code containing at least one piece of information on the dialysis solution.

Abstract: A medical compound preparation and delivery system, including a delivery device, the device including a depressible trigger operably coupled to move a plunger; a cartridge releasably coupled to the delivery device, the cartridge defining a lumen therethrough to receive at least a portion of the plunger therein; a receptacle defining a cavity therein for receiving a medical compound; a first tube slidably positionable within the cavity of the receptacle; and a second tube slidably positionable within the first tube, wherein the cartridge is slidably positionable within the second tube.

Abstract: Handheld gas spray systems for mixing and dispensing multi-component compositions.

Abstract: An injection system includes a handle assembly with a handle body having an outer surface surrounding a handle body interior and a plunger extending therethrough. A tubular handle collar is telescopically received in the handle body exterior and is axially movable with respect to the handle body. A syringe housing assembly is selectively connectable to the handle assembly and includes a syringe housing and a tubular syringe sleeve telescopically received through a distal end of the syringe housing and axially movable with respect thereto. The syringe housing has an exterior side surface surrounding a syringe housing interior configured to receive at least a portion of a syringe. The syringe sleeve has a proximal end, a distal end with a skin contact surface, and a generally cylindrically-shaped outer surface.

Abstract: A device for training users in a proper mixing of pharmaceutical components, or for aiding in the mixing, or for performing the mixing, and administration of pharmaceutical components is disclosed. The device comprises a housing for receiving a pharmaceutical delivery device containing the pharmaceutical components. There is also a microcontroller disposed in the housing and a motion/orientation detection device disposed within or on the housing and in communication with the microcontroller. A method for use of the device is also disclosed, along with a substance for use as one of the pharmaceutical components.

Abstract: Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.

Abstract: Apparatuses and methods for delivering a fluid, including a viscous fluid. These apparatuses may include a fluid reservoir, two or more piston chambers, a manifold, a delivery port, and a drive assembly and may be configured to inject either a predetermined amount of fluid or a continuous stream of fluid. These apparatuses may also be configured to switch between filling, injection and aspiration modes. These apparatuses may generally be hand-held and lightweight and may provide a significant mechanical advantage to the user.

Abstract: Disclosed herein is an anti-adhesion kit comprised of: (i) a fibrinogen solution component comprising: fibrinogen at a concentration of about 5 to 25 mg/ml; and free calcium ions at a concentration ranging from 0.1 ?M to 1 mM; and (ii) a thrombin component containing thrombin. Further disclosed is an anti-adhesion kit comprised of: (i) a fibrinogen solution component containing fibrinogen at a concentration of 8% to 25% of total protein by weight, and optionally free calcium ions at a concentration ranging from 0.1 ?M to 1 mM; wherein a total protein concentration ranges from about 80 to 120 mg/ml; and (ii) a thrombin component containing thrombin. Methods of using the kits e.g., to provide anti-adhesion curable compositions are also disclosed.

Abstract: A disposable transfer device has an injection device support surface for receiving an on-body injection device thereon and a flow path arrangement for transfer of fluid into the injection device, the transfer device being configured to define preferential gripping areas for user gripping of an injection device when such device is located on the support surface and interfering areas for interfering with user gripping of the injection device in the interfering areas.