Controlled Release Therapeutic Device Or System Patents (Class 604/890.1)
-
Patent number: 10456293Abstract: Disclosed is an ocular device including a first structure formed of a first material providing a first shape to the ocular device prior to positioning the ocular device on the surface of the eye, a second structure formed of a second, different material having a tubular structure and a lumen through which the first structure extends, and at least one therapeutic agent is dispersed within the second material of the second structure. The first shape of the ocular device conforms to a second, different shape after positioning the ocular device on the surface of the eye. Upon being removed from the eye, the ocular device retains the second shape or changes to a third shape different from both the first shape and the second shape. Related apparatus, systems and method are described.Type: GrantFiled: September 1, 2017Date of Patent: October 29, 2019Assignee: ForSight Vision5, Inc.Inventors: Anne Brody Rubin, Yair Alster, Cary J. Reich
-
Patent number: 10449155Abstract: The present invention provides carbonate apatites with a suitable particle size (average particle size and maximum particle size) as well as small variance (?2) of particle sizes. Provided is a method of manufacturing a carbonate apatite, the method comprising the step of incubating a mixture comprising a calcium ion, a phosphate ion, and a hydrocarbon ion, wherein an incubation temperature is 10° C. or lower and an incubation time of 10 minutes or less. Further, a carbonate apatite made by this method (e.g., carbonate apatite with a maximum particle size of 700 nm, average particle size of 30 nm and drug encapsulation rate of 98%, all in nanometer size) is provided.Type: GrantFiled: November 8, 2016Date of Patent: October 22, 2019Assignee: Medical Corporation IjunkaiInventor: Hiroyuki Nakanishi
-
Patent number: 10434285Abstract: An infusion set (101) includes a base (121), a flexible catheter (142) and an introducer needle (134). The flexible catheter (142) is movable from a first catheter position disposed substantially entirely within the base (121) to a second catheter position in which a free end of the flexible catheter (142) is disposed externally of the base (121). The introducer needle (134) is movable between a first introducer needle position disposed substantially entirely within the base (121) and a second introducer needle position in which a free end of the introducer needle (134) is disposed externally of the base (121). An activation button (161) is movable between first and second button positions.Type: GrantFiled: February 8, 2012Date of Patent: October 8, 2019Assignee: Becton, Dickinson and CompanyInventors: Ryan Schoonmaker, Cole Constantineau
-
Patent number: 10406336Abstract: Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.Type: GrantFiled: July 27, 2017Date of Patent: September 10, 2019Inventor: Neil S. Davey
-
Patent number: 10398372Abstract: The present disclosure provides a method for determining an effect of a drug on pain experienced by a patient. The method comprises providing reference information concerning at least one visible and/or audible feature that is indicative of a level of the pain. The method further comprises capturing information indicative of the at least one visible and/or audible feature, respectively, from the patient comprising observing the patient directly or indirectly after administering the drug to the patient. In addition, the method comprises determining pain indicating information associated with a level of pain experienced by the patient using the captured information. The method also comprises comparing the pain indicating information with the provided reference information to determine the effect of the drug on the pain experienced by the patient.Type: GrantFiled: February 17, 2017Date of Patent: September 3, 2019Assignee: ePAT Pty LtdInventors: Jeff Hughes, Kreshnik Hoti, Mustafa Abdul Wahed Atee
-
Patent number: 10368788Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.Type: GrantFiled: July 21, 2016Date of Patent: August 6, 2019Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Axel Scherer, Meisam Honarvar Nazari, Muhammad Mujeeb-U-Rahman, Mehmet Sencan, Arti Gaur
-
Patent number: 10293108Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.Type: GrantFiled: April 11, 2016Date of Patent: May 21, 2019Assignee: Medtronic MiniMed, Inc.Inventor: Anirban Roy
-
Patent number: 10280310Abstract: A monolayer film of nanoparticles can formed from a fluid mixture by combining nanoparticles dispersed in water with a water-miscible organic solvent and a molecular ligand comprising a head group with affinity for the nanoparticle, and introducing the fluid mixture to a substrate in the presence of an air/fluid interface, thereby causing a monolayer film of nanoparticles to form on the substrate. Such monolayers films can include metallic nanoparticles such as gold, and possess substantially uniform spacing over at least a one centimeter length scale. The films are metasurfaces effective to cause a range of linear refractive index of from around unity at 700 nm to 10 at 1500 nm. Such metasurfaces might find utility, for example, as ultrafast (picosecond scale) switches at wavelengths useful for telecommunications.Type: GrantFiled: July 24, 2017Date of Patent: May 7, 2019Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Jake Fontana, Jawad Naciri, Banahalli R. Ratna, Nicholas A. Charipar, Alberto Piqué
-
Patent number: 10265464Abstract: A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.Type: GrantFiled: October 15, 2015Date of Patent: April 23, 2019Assignee: Roche Diabetes Care, Inc.Inventors: Ofer Yodfat, Danna Perlman
-
Patent number: 10251836Abstract: A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.Type: GrantFiled: September 4, 2013Date of Patent: April 9, 2019Assignee: Arstat, Inc.Inventor: Arkady Rubin
-
Patent number: 10239236Abstract: Microneedle devices have projections that are generally sharp and elongated and designed to disrupt the upper layer of the skin, cause micro-indentations, or pierce the skin. High density arrays are produced using micro-fabrication or micro-molding techniques. The assembly of individual needles does not lend itself to the production of high density arrays. A method of forming microneedle arrays is disclosed which comprises attaching a plurality of microneedles to a substrate, and building up a 2-dimensional microneedle array by wrapping layers of the substrate around a core or folding the layers repeatedly back upon themselves. The arrays are capable of needle densities with a pitch within the range of needle radius plus several micrometers to millimeters.Type: GrantFiled: August 18, 2014Date of Patent: March 26, 2019Assignee: NDM Technologies LimitedInventor: Dewan Fazlul Hoque Chowdhury
-
Patent number: 10226575Abstract: Some embodiments of an infusion pump system can employ a number of power management techniques to avoid using substantially excessive power during operation of the pump drive system. Thus, the infusion pump system can draw upon the energy supply in an efficient manner that extends the useful life on the power supply. Furthermore, the infusion pump system can be configured estimate an amount of power remaining to operate the pump system without the requirement of directly detecting the remaining charge on power supply device (e.g., without detecting the remaining charge on a battery). As such, the infusion pump system can readily inform a user of a particular estimated amount of time remaining for medicine dispensing operations.Type: GrantFiled: August 4, 2016Date of Patent: March 12, 2019Assignee: Bigfoot Biomedical, Inc.Inventors: Steve Miller, Ken Mochel, David C. Rich
-
Patent number: 10195409Abstract: Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.Type: GrantFiled: March 10, 2014Date of Patent: February 5, 2019Assignee: Corium International, Inc.Inventors: Doug Bourne, Ashutosh Shastry, Anthony Le, Parminder Singh
-
Patent number: 10183127Abstract: The present invention relates to a pressure reducer for delivering drugs to a patient and the corresponding method of manufacture, said pressure reducer for delivering drugs to a patient comprising: a duct (9) with an inlet (11) and an outlet (13), a first body (1) with a first surface (5), and a second body (3) with a second surface (6) directly contacting the first body (1). One of the surfaces (5,6) has a recess (7) such that a duct (9) is defined between both surfaces. Both bodies are attached to one another by means of a continuous attachment line running on both sides of the duct (9). The method of manufacture comprises a laser welding step in which the first body (1) is welded to the second body (3) by means of a welding seam extending along both sides of the duct.Type: GrantFiled: May 6, 2013Date of Patent: January 22, 2019Assignee: LEVENTON S.A.U.Inventors: Jordi Martín Llorens, Javier Torras Marí
-
Patent number: 10172704Abstract: Eyewear is provided including a frame, and a camera connected with the frame, in which the camera is configured to be controlled by a remote controller. The camera may be configured to capture video and/or a photo. The eyewear may include data storage, and the camera may be connected to the data storage. A wrist watch may be configured to act both as a time piece and a controller of the camera. The eyewear may also include a heads up display and/or a video file player. The eyewear may also include an electro-active lens.Type: GrantFiled: August 3, 2015Date of Patent: January 8, 2019Assignee: e-Vision Smart Optics, Inc.Inventors: Ronald D. Blum, William Kokonaski, Dwight P. Duston
-
Patent number: 10102926Abstract: Example embodiments of a system, apparatus, computer readable media, and method are disclosed for improving clinical and financial outcomes for a healthcare provider The example embodiments may be used for aggregating data corresponding to care for a group of patients by at least one healthcare provider, generating a statistical model based on the aggregated data, periodically determining a current value for the treatment parameter associated with care of a patient provided by a healthcare provider, and causing treatment to be administered to the patient in response to applying the statistical model to determine that the current value for the treatment parameter is associated with an adverse outcome.Type: GrantFiled: October 14, 2015Date of Patent: October 16, 2018Assignee: SENTRY DATA SYSTEMS, INC.Inventor: Travis Leonardi
-
Patent number: 10099004Abstract: A portable medical apparatus for administering a fluid drug in doses, including a first housing including a reservoir unit with an outlet into a fluid path for conducting the drug, a second housing including a conveying unit for dispensing the drug from the reservoir unit in doses and a suitable controller for controlling the conveying unit, an adaptor including a coupling structure for receiving the first housing and the second housing and an attaching structure for extra-corporeally carrying the adaptor on a patient, wherein the conveying unit and the reservoir unit can be joined together to form an integrated mechanical and fluidic unit, and coupled to and decoupled from at least two differently configured adaptors, wherein at least one of the adaptors is configured to be directly attached to the surface of the skin and at least one of the adaptors is configured to be worn on or carried by an article of clothing or a wearing system (e.g., a belt).Type: GrantFiled: August 21, 2015Date of Patent: October 16, 2018Assignee: Roche Diabetes Care, Inc.Inventor: Marco De Polo
-
Patent number: 10058650Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.Type: GrantFiled: August 4, 2014Date of Patent: August 28, 2018Assignee: Becton, Dickinson and CompanyInventors: Gary M. Searle, Charles G. Hwang
-
Patent number: 9993209Abstract: According to an embodiment of the present invention, a system dynamically monitors a patient's physiological condition and location information to generate an alarm signal to enable the patient to timely administer a health substance. Initially, the system monitors location information of a health substance and the patient and physiological information of the patient. A processor in the system determines a predicted time when the patient may attain a physiological condition for receiving the health substance and may further determine a transit time for the patient to travel to a location of the health substance. Based on the predicted and transit times, the system issues an alarm signal to the patient prior to the predicted time. Embodiments of the present invention further include a method and computer program product for monitoring a patient's physiological condition and location information to generate an alarm signal in substantially the same manner described above.Type: GrantFiled: April 24, 2017Date of Patent: June 12, 2018Assignee: International Business Machines CorporationInventors: Kanako Fujitani, Mariko Ishige, Yusuke Nishitani, Yutaka Oishi, Tatsuya Sobue, Masayuki Yamana
-
Patent number: 9949921Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.Type: GrantFiled: January 11, 2016Date of Patent: April 24, 2018Assignee: Agigma, Inc.Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
-
Patent number: 9943228Abstract: A functional skin patch having a first surface and a second surface opposite the first surface is provided. The functional skin patch includes a functional unit having a thermo harvester and an antenna unit. The thermo harvester has a first terminal thermally connected to the first surface and a second terminal. The antenna unit has a first terminal thermally connected to the second terminal of the thermo harvester and a second terminal thermally connected to the second surface. The antenna unit has a stacked layer structure including, in this sequence, a metal layer thermally connected to the second terminal of the thermo harvester, a ferrite layer thermally connected to the metal layer, and an antenna layer thermally connected to the ferrite layer.Type: GrantFiled: November 11, 2015Date of Patent: April 17, 2018Assignee: Infineon Technologies AGInventors: Robert Kappel, Thomas Herndl, Gerald Holweg, Walther Pachler
-
Patent number: 9943647Abstract: A pharmaceutical injection device comprises a main body case (2); a pharmaceutical syringe mounting component (3) that is provided inside the main body case (2) and onto which a pharmaceutical syringe (4) is mounted; a piston (5) provided movably with respect to the pharmaceutical syringe (4) mounted onto the pharmaceutical syringe mounting component (3); a drive mechanism (6) for driving the piston (5); a memory (46) that stores a preset pharmaceutical injection schedule; and a controller (7) that resets a current pharmaceutical dose by comparing a planned cumulative pharmaceutical dose, which is a planned cumulative amount of pharmaceutical injected up to the last time on the basis of the pharmaceutical injection schedule stored in the memory, and an actual cumulative pharmaceutical dose, which is a cumulative amount of pharmaceutical actually injected up to the last time.Type: GrantFiled: October 5, 2012Date of Patent: April 17, 2018Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.Inventors: Yasutaka Mukai, Seiji Kikuchi, Tsuguhiro Kondoh
-
Patent number: 9919103Abstract: Containment devices and methods of manufacture and assembly are provided. In an embodiment, the containment device includes an elongated microchip element comprising one or more containment reservoirs that are configured to be electrically activated to open. The containment device also include an elongated electronic printed circuit board (PCB) comprising a substrate. The elongated PCB comprises a first side on which one or more electronic components are fixed and an opposed second side on which the elongated microchip element is fixed in electrical connection to the one or more electronic components. Further, the containment device includes an elongated housing fixed to the elongated PCB. The elongated housing is configured to hermetically seal the one or more electronic components of the elongated PCB within the elongated housing.Type: GrantFiled: December 20, 2013Date of Patent: March 20, 2018Assignee: MICROCHIPS BIOTECH, INC.Inventor: Robert Farra
-
Patent number: 9919104Abstract: The protrusion relates to a device comprising a main body case having a sensor mounting component, a measurement component that is connected to the sensor mounting component, a controller that is connected to this measurement component, and a display component that is connected to this controller. A communication component that is connected to the controller communicates pharmaceutical injection information and non-pharmaceutical-injection information to a specific pump. The controller performs communication at a first output when communicating non-pharmaceutical-injection information to the pump, and performs communication at a second output that is smaller than the first output when communicating pharmaceutical injection information to the pump.Type: GrantFiled: February 15, 2013Date of Patent: March 20, 2018Assignee: Panasonic Healthcare Holdings Co., Ltd.Inventor: Akiyoshi Ohzawa
-
Patent number: 9913698Abstract: Disclosed is a medicine ingestion state management method capable of objectively managing medicine ingestion states of patients. The medicine ingestion state management method involves an operation of prescribing medicine (10) encapsulating, together with a medicament, a medicine information transmitting unit (20) having a function of transmitting medicine information capable of specifying a type and a quantity of the medicament to each individual patient, and an operation of grasping the medicine ingestion state of each patient by collecting the medicine information from each medicine information transmitting unit (20) in each patient.Type: GrantFiled: February 24, 2006Date of Patent: March 13, 2018Assignee: FUJITSU LIMITEDInventors: Hitoshi Kimura, Morihito Notani
-
Patent number: 9884011Abstract: In one aspect, an ingestible, electrical device, comprises a substrate comprising a reservoir that is configured to hold one or more substances; a first film covering the reservoir, wherein the first film is at least partially metallic; a charge storage system connected to the first film, the charge storage system configured to deliver a transient electrochemical potential to the first film; wherein the first film is configured to prevent exposure of the substance to an aqueous environment in an organism, while the charge storage system delivers the transient electrochemical potential to the first film; and wherein the first film is configured for dissolution to expose the one or more substances to the aqueous environment in the organism, after the charge storage system stops delivering the transient electrochemical potential to the first film.Type: GrantFiled: October 23, 2014Date of Patent: February 6, 2018Assignee: Carnegie Mellon UniversityInventor: Christopher J. Bettinger
-
Patent number: 9855256Abstract: Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.Type: GrantFiled: May 3, 2016Date of Patent: January 2, 2018Assignee: Omeros CorporationInventors: Gregory A. Demopulos, Jeffrey M. Herz, Wayne R. Gombotz, Hui-rong Shen
-
Patent number: 9855011Abstract: A measurement device includes a sensor attached to a biosensor which includes a reagent that selectively responds to a specific analyte in a biological fluid, an analyte measurer that measures a concentration of the specific analyte with a biosensor, and a motion measurer that measures a motion level of the measurement device. A recorder records the concentration of the analyte and motion information, and a controller connects the analyte measurer and the motion measurer and controls the analyte measurer and the recorder based on the controller motion information. The controller includes a damage determiner that judges whether or not the measurement device is damaged, based on the motion level.Type: GrantFiled: February 14, 2017Date of Patent: January 2, 2018Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.Inventors: Noriyoshi Terashima, Masataka Nadaoka
-
Patent number: 9855420Abstract: One aspect relates to a medical implant, for example, implantable stimulation electrode, having a tight substrate and a porous contact region. One aspect also relates to a lead of a cardiac pacemaker having an implantable stimulation electrode and to a method for manufacturing a medical implant, for example, an implantable stimulation electrode. A medical implant according to one aspect is characterized in that the implant includes a sintered body with graduated porosity.Type: GrantFiled: February 10, 2015Date of Patent: January 2, 2018Assignee: Heraeus Deutschland GmbH & Co. KGInventors: Heiko Specht, Andreas Reisinger, Goran Pavlovic
-
Patent number: 9840789Abstract: A nanoporous metal structure is made by etching a metal alloy structure of two or more metals. Less than all of the metals are selectively removed (e.g., dissolved in solution) from the alloy in the presence of an alternating voltage profile, for example, a periodic voltage profile. The resulting nanoporous metal structure, having pore openings of about 20 nm to about 500 nm in diameter and a purity of at least about 70%, can be further treated to alter some or all of the structure, and/or to add, remove and/or modify properties thereof.Type: GrantFiled: January 20, 2014Date of Patent: December 12, 2017Assignee: CITY UNIVERSITY OF HONG KONGInventors: Jie Zhang, Yang Yang Li, Jian Lu
-
Patent number: 9837191Abstract: Embodiments are directed to a method for manufacturing a product comprising: establishing, by a computing device comprising a processor, at least one parameter of a particular instance of a component to be used in the product, adapting, by the computing device, a baseline model of the component based on the at least one parameter to accommodate use of the particular instance of the component, growing a structure based on the adapted model to accommodate the particular instance of the component using an additive manufacturing technique, coupling the structure to the particular instance of the component, growing an electrical harness by using additive printing to establish an electrical cable, and assembling the product by coupling the electrical harness to the particular instance of the component.Type: GrantFiled: January 2, 2014Date of Patent: December 5, 2017Assignee: RAYTHEON COMPANYInventor: Rigel Q. Woida-O'Brien
-
Patent number: 9827356Abstract: A catheter pump is disclosed herein. The catheter pump can include an elongate catheter body and an impeller assembly coupled to a distal portion of the elongate catheter body. The impeller assembly can comprise an impeller configured to rotate during operation of the catheter pump. A tube can extend through at least portions of the elongate catheter body and the impeller assembly. The tube can extend distal the impeller and can be configured to remain in the portions of the elongate catheter body and the impeller assembly during operation of the catheter pump.Type: GrantFiled: April 15, 2015Date of Patent: November 28, 2017Assignee: TC1 LLCInventors: Paul F. Muller, Keif M. Fitzgerald, Richard L. Keenan
-
Patent number: 9820884Abstract: A device for delivering a treatment medium to an eye includes a first body portion configured to be removably inserted and secured in an opening of the eye, and a second body portion supported by the first body portion. At least the second body portion includes a treatment medium, and a coating having an opening through which the treatment medium elutes out of the device.Type: GrantFiled: October 6, 2015Date of Patent: November 21, 2017Assignee: Mati Therapeutics Inc.Inventor: Eliot Lazar
-
Patent number: 9808608Abstract: A delivery device including a substrate formed in a coil comprising a plurality of loops, an active agent deposited between an inner surface and an outer surface of the substrate formed in the coil, and a pair of end caps, each end cap disposed on a corresponding end of the coil.Type: GrantFiled: November 16, 2014Date of Patent: November 7, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventor: Bucknell C. Webb
-
Patent number: 9808577Abstract: The present invention relates to a device, system and a method for optimizing syringe based drug delivery profile with a treatment element and in particular, to such a device, system and method in which optimization is based on a plurality of data that directly and/or indirectly affect the optimization of the drug delivery profile. The device facilitating syringe based drug delivery, by optimizing drug delivery of the injected drug, records user's activity, and data relative to drug injections, comprising a disposable unit configured for a single use period and a rechargeable reusable unit having electronics comprising a sensor module.Type: GrantFiled: May 10, 2012Date of Patent: November 7, 2017Assignee: Insuline Medical Ltd.Inventors: Ron Nagar, Gabriel Bitton, Elisha Amir, Moshe Fadlun
-
Patent number: 9721409Abstract: A wearable device may include a sensor system capable of obtaining physiological from a user's body. Some wearable devices may include a substance delivery system. A sensor system of a wearable device may include at least one “bio-assurance sensor” capable of obtaining biometric data that may be used to identify a user. For example, the bio-assurance sensor may be used to ensure that the wearable device is not removed from the user's body and/or placed on or in another user's body. In some examples, the wearable device may be used with a second device, such as a smart phone, that includes at least one “authentication sensor,” such as a fingerprint sensor, that also may be used to identify a user. However, in some implementations the wearable device may include at least one authentication sensor.Type: GrantFiled: May 2, 2014Date of Patent: August 1, 2017Assignee: QUALCOMM IncorporatedInventors: Muhammed Ibrahim Sezan, John Keith Schneider, Kenneth Kaskoun, Eugene Dantsker
-
Patent number: 9717896Abstract: Systems and methods are described for implementing or deploying one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature.Type: GrantFiled: December 18, 2007Date of Patent: August 1, 2017Assignee: GEARBOX, LLCInventors: Bran Ferren, Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
-
Patent number: 9675812Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.Type: GrantFiled: April 1, 2015Date of Patent: June 13, 2017Assignee: ELWHA LLCInventors: Roderick A. Hyde, Edward K. Y. Jung, Eric C. Leuthardt, Gary L. McKnight, Lowell L. Wood, Jr.
-
Patent number: 9656020Abstract: According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.Type: GrantFiled: June 9, 2010Date of Patent: May 23, 2017Assignee: IMPERIAL INNOVATIONS LIMITEDInventors: Pantelis Georgiou, Kok Thay Lim, Christofer Toumazou
-
Patent number: 9636460Abstract: A pneumatic autoinjector that, once activated, automatically mixes at least two components in a pre-filled chamber and then ejects the mixture in a manner suitable for medicament injection. The mixable components may be a dry/wet combination (e.g., powder and solvent), wet/wet combination (e.g., two pre-diluted medicaments), wet/gas combination (e.g., chemical A and gas B), or gas/gas combination. In some embodiments, autoinjectors made in accordance with the teachings of the present disclosure may automatically perform a sequence comprising thorough medicament mixing (e.g., reconstitution of a dried medicament with solvent), an optional pause to enhance medicament dissolution or suspension, optional needle insertion into the patient (not required in needle-free embodiments), medicament injection into the patient, and optional needle retraction for safe storage.Type: GrantFiled: December 28, 2016Date of Patent: May 2, 2017Assignee: Creare LLCInventors: Michael D. Jaeger, Mark C. Bagley, Roger W. Hill, Sandra J. Graveson, Robert T. Payne
-
Patent number: 9622979Abstract: The present invention relates to a multilayered coated tablet comprising at least three layers, i.e., first, second and third layer wherein the first and third layers contain at least one active pharmaceutical ingredient and the second layer is either a placebo or an immediate-release drug layer. Further, the tablet has a delayed-release coating, wherein the coating may contain one or more pore-forming agents and/or orifices on one or both sides. Furthermore, it may contain an immediate-release layer of the drug over the delayed-release coating layer. The present invention further relates to processes for preparing such a multilayered coated tablet.Type: GrantFiled: June 29, 2012Date of Patent: April 18, 2017Assignee: Sun Pharmaceutical Industries LimitedInventors: Murali Krishna Bhavarisetti, Kumaravel Vivek, Sreekanth Narravula, Romi Barat Singh
-
Patent number: 9622690Abstract: A measurement device includes a housing that has an attached biosensor that includes a reagent selectively responding to a specific analyte in a biological fluid, and is configured so as to be carried by a user, an analyte measurer that measures a concentration of the specific analyte with a biosensor, and a motion measurer that measures a motion level of the housing. A living activity level calculator calculates a living activity level of the user based on the motion level measured by the motion measurer, a recorder records the living activity level calculated by the living activity level calculator, and a controller associates the concentration of the specific analyte measured by the analyte measurer with an event of living activity of the user, estimated based on the living activity level recorded in the recorder, and records them in the recorder.Type: GrantFiled: October 17, 2013Date of Patent: April 18, 2017Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.Inventors: Noriyoshi Terashima, Masataka Nadaoka
-
Patent number: 9579512Abstract: An implantable medical device includes circuitry for generating and delivering electrical stimulation therapy. A power source is included in the implantable medical device for storage of the energy for the stimulation therapy. Techniques and circuits are provided for minimizing energy losses associated with the storage of the stimulation therapy energy. The implantable medical device circuitry includes charging circuitry that is operated in at least a first mode and a second mode, such that the charging circuit is operable in one of the at least first and second modes based on whether an intrinsic cardiac event is detected. The charging circuit is operable to withhold charging the output capacitor in the first mode until a given cardiac cycle elapses without a sensed intrinsic cardiac event.Type: GrantFiled: May 14, 2015Date of Patent: February 28, 2017Assignee: Medtronic, Inc.Inventor: Wade M Demmer
-
Patent number: 9566248Abstract: An encased-pellet tablet for an active pharmaceutical ingredient comprises an excipient layer on the outside and an inner core that is surrounded by the excipient layer. The inner core contains a plurality of coated pellets, and the coated pellets comprise pellets of the active pharmaceutical ingredient coated with a pellet coating. The excipient layer contains from about 1 wt. % to about 20 wt. % of at least one cushioning agent selected from polyhydroxyl compounds. A method for manufacturing the encased-pellet tablets involves compressing an excipient material to form a first layer; compressing a plurality of coated pellets containing an API on said first layer to form an inner core thereon and compressing additional excipient material around an exposed portion of said inner core thereby surrounding said inner core with excipient material.Type: GrantFiled: September 12, 2014Date of Patent: February 14, 2017Assignee: R.P. Scherer Technologies, LLCInventors: Harry G. Cocolas, Christin P. Hollis
-
Patent number: 9526825Abstract: A drug infusion system includes a first infusion pump including a processor and a user interface in operable communication with the processor, and a second infusion pump, wherein the processor of the first infusion pump (i) enables an operator to make a selection using the user interface, the selection specifying a combination of a plurality of drugs to be delivered to a patient using the first and second infusion pumps, and (ii) commands the first infusion pump to deliver one or more drug of the combination to the patient and the second infusion pump to deliver one or more drug of the combination to the patient.Type: GrantFiled: October 10, 2014Date of Patent: December 27, 2016Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Natalie McTaggart, James P. Martucci
-
Patent number: 9460135Abstract: The current document is directed to automated electronic testing, optimization, and/or analysis systems that perform testing that results in non-binomial experimental results that are processed by using efficient and robust processing methods. In one implementation, efficient and robust processing methods are employed to process non-binomial results produced from single-factor tests. In a second implementation, robust and computationally efficient processing methods are employed to analyze non-binomial results from multi-factor/multi-level tests.Type: GrantFiled: September 10, 2013Date of Patent: October 4, 2016Assignee: Webtrends Inc.Inventors: Vladimir Brayman, Lihui Shi, Spencer Wood
-
Patent number: 9457176Abstract: Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.Type: GrantFiled: October 6, 2011Date of Patent: October 4, 2016Assignee: TARIS Biomedical LLCInventors: Heejin Lee, Hong Linh Ho Duc
-
Patent number: 9439582Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.Type: GrantFiled: November 24, 2014Date of Patent: September 13, 2016Assignee: Proteus Digital Health, Inc.Inventors: Jeffrey Berkman, Mark Zdeblick, Patricia Johnson, Hooman Hafezi, Jonathan Withrington
-
Patent number: 9439743Abstract: There is a concern that a mechanical switch could be switched OFF due to movement of a body in which the switch is embedded. If the switch is switched OFF after being embedded, it is difficult to switch the switch back ON. Provided is a fluid delivery device that is used by being embedded within a body, including a fluid delivery mechanism for discharging fluid from a reservoir that contains the fluid to outside of the reservoir; a sending and receiving section that sends and receives information relating to control of the fluid delivery mechanism to and from an external apparatus; a power supply section that supplies power to at least one of the fluid delivery device and the sending and receiving section; and a mechanical switch that is capable of changing a supply path of the power only from a cutoff state to a conductive state.Type: GrantFiled: August 24, 2015Date of Patent: September 13, 2016Assignee: PRIMETECH CORPORATIONInventors: Ryosuke Ogihara, Susumu Kobayashi
-
Patent number: 9421351Abstract: An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.Type: GrantFiled: June 27, 2006Date of Patent: August 23, 2016Assignee: ALZA CORPORATIONInventors: Joseph C. Trautman, Lorin Olson