Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one such device, target cells are stimulated using an implantable device. The device includes a light source for producing light from electrical power. An optical transmission element is made from a material that is substantially transparent to the light from the light source. This transmission element substantially encases the light source at a proximal end. The transmission element delivers light from the light source to a distal end. The shape and size of the transmission element facilitates implanting of the element within a patient. A fixation portion physically couples to the optical transmission element and secures the device to the patient. A heat dissipation portion removes heat from the near optical transmission element and the light source and dissipates the removed heat through the fixation portion.

Abstract: Methods and systems for modifying tissue use a pressurized fluid stream carrying coherent light energy. The methods and systems may be used for resecting and debulking soft and hard biological tissues. The coherent light is focused within a stream of fluid to deliver energy to the tissue to be treated.

Abstract: A forceps includes an end effector assembly having first and second jaw members movable relative to one another between a spaced-apart position, a first approximated position, and a second approximated position. One or both of the jaw members including a first stop member coupled thereto and disposed between the jaw members. The first stop member is longitudinally translatable along a surface of the at least one jaw member from a first position, wherein the first stop member inhibits approximation of the jaw members beyond the first approximated position, and a second position, wherein the first stop member inhibits approximation of the jaw members beyond the second approximated position.

Abstract: A method for performing wavefront-guided laser surgery on a cornea includes the step of calculating a corneal flap configuration based upon collected anatomical information on an eye and wavefront data on a cornea of the eye. Such data may be collected by, for example, an aberrometer, although this is not intended as a limitation. The calculated configuration is transmitted to a processor in controlling relation to a corneal flap-cutting device. The flap-cutting device is used to create a corneal flap based upon the calculated configuration. A system for performing wavefront-guided laser surgery on a cornea includes a processor for receiving the anatomical information and wavefront data. A software package is adapted to calculate the corneal flap configuration and to control a corneal flap-cutting device to cut a corneal flap commensurate with the calculated corneal flap configuration.

Abstract: A handpiece can treat biological tissue using electromagnetic radiation, which can be substantially fluorescent light. The handpiece includes a source of electromagnetic radiation and a waveguide. The waveguide is adjacent the source, receives electromagnetic radiation from the source, and delivers the electromagnetic radiation to the biological tissue. The handpiece also includes a system for circulating a fluorescent substance through the waveguide. The fluorescent substance is capable of modulating at least one property of the electromagnetic radiation.

Abstract: Methods for imaging or optical sensing of a material are provided. A first fluorescent image or optical signal of a material can be recorded, the material can be perturbed, and then a second fluorescent image or optical signal of the material can be recorded. The two fluorescent images or signals can be subtracted to give a differential image or optical signal.

Abstract: An ophthalmic docking system is presented that can reduce a condensation of a patient interface of a surgical laser system. The ophthalmic docking system includes a patient interface that has a proximal portion configured to be attached to an ophthalmic system, a distal portion configured to be attached to an eye that includes a contact lens and an interface attachment system; and a decondenser, coupled to the patient interface and configured to reduce a vapor condensation on the contact lens.

Abstract: Disclosed is an exemplary illumination device for enhancing the brightness of wavelength converting element. The illumination device includes a wavelength converting element operable for receiving light from a light source at a first wavelength range and converting the light to a second wavelength range. The wavelength converting element includes a first face, a second face opposite the first face, and a side edge extending between the first and second faces. A reflective optical element is arranged adjacent the side edge of the wave converting element. The reflective optical element is configured to reflect light in at least the first wavelength range toward the wavelength converting element.

Abstract: A noninvasive method of reducing fat from targeted regions of a patient's body by applying low-level laser energy externally through the skin of the patient to the targeted areas. Sufficient laser energy is applied to release at least a portion of intracellular fat into the interstitial space. The released intracellular fat is removed from the body through the body's natural functions. The preferred embodiment uses laser energy at about 635 nm.

Abstract: An improved system for safe and efficient generation of plasmas and vapors bubbles with continuous wave radiations and low levels of power densities, sufficient to treat medical pathologies and to avoid the creation damage to healthy tissue is provided. Transmission means in different configurations are used to achieve a high absorption in water, which is able to initiate plasma with low levels of power density. Once plasma and vapor bubbles are formed, they absorb other wavelengths in addition to the one that initiated it. Other wavelengths, more efficiently generated by diodes or diode pumped lasers, are added into the beam to improve treatment efficiency. This modulated plasma produces fast tissue ablation and good hemostasis effect with minimal overheating of remaining tissue. After plasma and high-energy vapors are generated, only laser radiation that passes through the plasma bubble directly interacts with soft tissues.

Abstract: Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

Abstract: A laser system for body tissue treatment has laser source, control device, scanner, and handpiece with treatment head transparent to the laser beam. An incoming laser beam section enters the treatment head longitudinally. The treatment head has a conical output surface with a minimum and a maximum surface radius and a half opening angle for total reflection of the incoming beam section. The reflected beam section is refracted radially into an emerging beam section away from the treatment head through the output surface. The incoming beam section has at the output surface a mean diameter that is ?a difference of maximum surface radius and minimum scanning radius. A conical scanning surface as a part of the conical output surface extends from the minimum scanning radius to the maximum surface radius. The control device controls the scanner for scanning the conical scanning surface with the incoming beam section.

Abstract: An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening has abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system.

Abstract: An apparatus and method for thermally destroying tumors. A tip has a plurality of deployable thermal conductive elements whose temperatures are individually controllable. This allows the shape of the thermal field to be controlled and for specific areas to be protected from excessive heat by cooling those specific areas while ablating other areas. In another embodiment, the deployable thermal conductive elements are individually deployable to various lengths to further aid in shaping the thermal field. The temperatures and the shape of the thermal field may be monitored and controlled by a data processing device, such as a microprocessor. Further selectivity in defining the area of tissue to be treated may be achieved by introducing into the tissue thermal additives that alter the thermal properties of the tissue.

Abstract: An integral laser imaging and coagulation apparatus, and associated systems and methods that allow an ophthalmologist to perform laser retinal surgical procedures with an integral laser imaging and coagulation apparatus disposed at a first (i.e. local) location from a control system disposed at a second (i.e. remote) location, e.g., a physician's office. In some embodiments, communication between the integral laser imaging and coagulation apparatus and control system is achieved via the Internet®.

Abstract: Described herein are methods, systems, and devices for automated laser ablation and/or tissue resection triggered by Raman spectroscopic information. These systems and methods provide for precise removal of cancerous or other diseased tissue with minimal damage to adjacent healthy tissue.

Abstract: An antifungal treatment system includes a light source. The light source may be positioned in a housing having an exit aperture. The light source may be energized to generate a concentrated beam of electromagnetic radiation. The electromagnetic radiation may be visible light radiation that includes infrared radiation. When energized, the concentrated beam may be directed out of the exit aperture by the light source. A focal point of the concentrated beam may be provided in a target area external to the housing to penetrate a human nail and destroy fungus resident thereunder.

Abstract: An aesthetic treatment device and method for treating the skin of a patient, the device comprising at least one of a plurality of arc lamps, each arc lamp provided with a reflector for obtaining a substantially collimated beam; a pulse generator for generating a train of pulses of electrical energy for energizing said at least one of a plurality of arc lamps; a control unit for controlling pulse shape, amplitude, width, frequency and timing, for obtaining controllable spectral output and energy of the collimated beam through an application end of the device to a designated area of skin of the patient. The device can further comprise secondary light sources with different spectrum characteristics than the arc lamp as well as various attachments including a position feedback, material dispenser, skin cooler, and docking station for optical fiber.

Abstract: A system of surgical accessories for a surgical robotic arm is provided, the system comprising: at least one working channel coupled to an optical fiber; a universal accessory adapter having: a first end coupled to a working end of the surgical robotic arm, a second end configured with an opening that exposes the at least one working channel; and an accessory fastener, wherein said universal accessory adapter is configured for securing an accessory device to the second end.

Abstract: A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including insulation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.

Abstract: An apparatus for ophthalmological, in particular refractive, laser surgery includes a laser-beam source (20) for emitting a focused treatment laser beam (20?) and also includes an optical-coherence interferometric measuring device (34), for example an OLCR pachymeter, for measuring the z-position of a predetermined point of an eye to be treated in the coordinate system of the laser-surgery apparatus. A computer (C) serving as evaluating and control unit has been set up to assess, on the basis of the measured z-position, whether a desired treatment point of the eye in the z-direction falls in the focal plane of the treatment laser beam or is offset in relation to said plane. Depending on whether or not the patient is correctly positioned in relation to the focal plane, the computer (C) can bring about a range of actions.

Abstract: The present invention generally relates to methods for assessing the completeness of a varicose vein ablation. The method involves the use of imaging and/or functional measurement data to determine the extent to which a varicose vein has closed as a result of an ablation procedure.

Abstract: A portable, small-footprint laser device contains one or more housings in which a laser energy source and an optical arrangement are disposed. The housing produces a laser beam spot that may be rotated and scanned to apply laser energy to a target area. The laser device receives treatment parameters and uses them to program a treatment regimen in which activation and movement of the housings is automated. The laser device may be used to apply a treatment regimen to a patient's hands or feet that are infected by Onychomycosis. In the treatment regimen, certain wavelengths of laser energy are applied at a predetermined duration. The treatment may be repeated, and a topical anti-fungal medication may be applied to aid in the efficacy of the treatment.

Abstract: An ablation catheter includes an elongated sheath configured for intravascular usage, and an inner tube disposed within the elongated sheath. The inner tube is rotatable and translatable relative to the sheath. An optical fiber is disposed within the inner tube and extends longitudinally therethrough. A proximal end of the optical fiber is optically coupled to a light source and a distal end of the optical fiber is connected to a beam director configured to focus energy on target tissue inside a blood vessel to ablate the target tissue.

Abstract: Embodiments of an apparatus and method for sealing of tissue during uncontrollable bleeding situations during surgery are described. In one aspect, an apparatus comprises a laser unit and a laser beam delivery unit. The laser unit is configured to emit a laser beam suitable for sealing an opening on a tissue. The laser beam delivery unit is detachably coupled to the laser unit, and is configured to guide and direct the laser beam to seal the opening on the tissue.

Abstract: An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is well suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, for instance, the arteriovenous graft system includes a first valve device positioned at the arterial end and a second valve device positioned at the venous end. In one embodiment, the valve devices may include an inflatable balloon that, when inflated, constricts and closes off the arteriovenous graft. If desired, a single actuator can be used to open and close both valve devices.

Abstract: An apparatus and method are provided for spatially-selective administration of actions by at least one device in the body using a transducer that is sensitive to a spatially-variant energy field imposed on the at least one device by a source external to a subject's body; and at least one component in the at least one device, wherein interaction of the transducer with the imposed spatially-variant energy field causes or enables at least one component in the at least one device to affect nearby tissues in the body.

Abstract: An ablation device includes a waveguide that guides a pulse laser output from a laser output unit, a laser emitting unit that focuses the pulse laser guided by the waveguide using a lens, emits the pulse laser to a living body tissue, causes multiphoton absorption in a focal position of the pulse laser, and performs ablation on the living body tissue; and a balloon that sets a focus of the pulse laser as the laser emitting unit is positioned at a desired position inside a living body lumen.

Abstract: A sensor for detecting the presence of skin is disclosed, one configuration of which uses multiple light emitting diodes, each of a unique wavelength band, and a broad-band photodetector to measure the remission of light at multiple wavelengths from a material being analyzed. Characteristics of the spectral remission of the material are used to discriminate human skin from materials that are not human skin. Further, an aesthetic medical device utilizing such a sensor in which the device is inhibited from operation if skin has not been detected. The incorporation of a skin sensor improves the safety of devices that emit radiation that otherwise would pose a hazard if not directed onto skin.

Abstract: A system and method of treating target tissue that includes generating a treatment beam of light using a light source, directing the treatment beam onto target tissue using an optical element, generating an image of the target tissue from light emanating from the target tissue using a plurality of optical elements, and translating the light source, the optical element and/or the plurality of optical elements relative to the target tissue (using a translation device) to simultaneously move the treatment beam along the target tissue and the field of view of the target tissue as defined by the plurality of optical elements. Control electronics control the translation device to cause the treatment beam to move along the target tissue in a predetermined pattern.

Abstract: A curve information acquisition unit configured to acquire information on a shape of a curvature changing portion of which a radius of curvature changes according to a predetermined function, a driving support unit configured to perform driving support for the driver at the time when the vehicle moves in the curvature changing portion, and a driving support control unit configured to decide timing at which the driving support unit performs driving support, based on the information on the shape of the curvature changing portion acquired by a curvature changing information acquisition unit.

Abstract: A system and method for altering the shape of a lamina of transparent material (e.g. the cornea of an eye), as it is being subjected to a transverse pressure differential, requires a computer controlled laser unit. In accordance with specified input parameters, the computer directs the laser unit to perform LIOB over predetermined surfaces within the lamina. This weakens the material for a desired reshaping of the lamina in response to the pressure differential. With respect to a perpendicular axis that is defined by the lamina, surfaces parallel to the axis (e.g. cylindrical surfaces) are separated from each other by about two hundred microns. For surfaces perpendicular to the axis, the separation is about ten microns. In each instance, the cuts that result from LIOB are only about two microns thick.

Abstract: The invention relates to a system for ophthalmology or dermatology, having a laser unit for generating pulsed laser radiation, the pulse length of the laser pulses lying in the femtosecond range, a hand unit for emitting laser radiation generated by the laser unit, and a flexible light waveguide for delivering the laser radiation generated by the laser unit to the hand unit. The invention furthermore relates to a corresponding hand unit for emitting pulsed laser radiation generated by a laser unit, the laser radiation having pulse lengths in the femtosecond range.

Abstract: A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: Devices and methods for cleaning an oral cavity by positioning a device suitable for detecting and removing plaque from the surface within the oral cavity having applied thereto a fluorescent agent capable of binding to plaque on the surface. The surface is substantially simultaneously cleaned and irradiated with a light of a wavelength effective to provide a fluorescent emission when contacted with said fluorescent agent. A portion of the fluorescent emission is collected (APV1), and compared to a predetermined threshold value (PPTV). If APV1 is less than PPTV, the device is moved to another section. If APV1 is greater than or equal to PPTV, then another portion of fluorescent emission is collected (APV2). The percent reduction from APV1 to APV2 determines when the device is moved to another section.

Abstract: Laser systems operating at two or more wavelengths.

Abstract: A technique for detecting and providing alerts or indications that can be used for controlling or altering the displacement speed of an applicator coupling skin heating energy across a treated skin. A temperature sensor monitors the rate of skin temperature change and provides feedback related to altering the applicator displacement speed according to the rate of skin temperature change. Disclosed is also an applicator for implementing this method.

Abstract: A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering to the microscope slide (18).

Abstract: Embodiments of methods and systems for hair treatment are disclosed. According to various embodiments, light is used to shave, trim, or otherwise modify hair shafts.

Abstract: Methods and systems for separating an object, such as a lead, from formed tissue are provided. Specifically, a tissue slitting device is configured to engage patient formed tissue at a slitting engagement point. While the object is subjected to a first traction force, the tissue slitting device is caused to move further into the engaged tissue and slit the tissue past the point of engagement. The slitting device causes the tissue to separate along an axial direction of the length of the formed tissue and releases at least some of the force containing the object. The methods and systems are well suited for use in cardiac pacing or defibrillator lead explant procedures.

Abstract: The invention relates to a device for shortening hairs growing from human skin. The device has a laser source for generating a laser beam during a predetermined pulse time, an optical system for focusing the laser beam into a focal spot, and a laser beam manipulator for positioning the focal spot in a target position. According to the invention, a dimension of the focal spot and a power of the generated laser beam are such that, in the focal spot, the laser beam has a power density which is above a characteristic threshold value for hair tissue above which a laser induced optical breakdown (LIOB) phenomenon occurs in the hair tissue. The LIOB phenomenon results in a number of mechanical effects in the hair tissue, such as cavitation and the generation of shock waves, which damage the hair in positions surrounding the position in which the LIOB phenomenon occurs.

Abstract: A method can include targeting a region of interest below a surface of skin, which contains fat lobuli and delivering ultrasound energy to the region of interest. The ultrasound energy generates a conformal lesion with said ultrasound energy on a surface of a fat lobuli. The lesion creates an opening in the surface of the fat lobuli, which allows the draining of a fluid out of the fat lobuli and through the opening. In addition, by applying ultrasound energy to fat cells to increase the temperature to between 43 degrees and 49 degrees, cell apoptosis can be realized, thereby resulting in reduction of fat.

Abstract: A clearing module is provided that includes a main body configured and dimensioned to be received within a vessel or duct of a patient, adjacent a surgical target area in the patient. The main body includes: an instruction receiving unit configured to receive wireless instructions from an instruction transmitter located outside the patient's body while the module is located inside of the patient's body; a positioning element configured to be monitored by a system external of the patient's body while the positioning element is inside the patient's body; and a destructive energy emitter configured to emit destructive energy from the module toward the surgical target area according to instructions received from the instructions receiving unit.

Abstract: The present invention generally relates to an apparatus and processes for preventing or delaying presbyopia. More particularly, the present invention relates to processes and apparatus for ablating epithelial cells in the germinative zone or the pregerminative zone of the crystalline lens of the eye so that onset or progression of presbyopia or one or more symptoms is delayed or prevented.

Abstract: An apparatus and corresponding method for treatment of skin conditions which includes a brushhead member which comprises a first portion which includes a plurality of rings of bristle tufts, the first portion oscillating in operation through a selected angle at a selected frequency and a second portion which also includes a plurality of rings of bristle tufts concentric with the first portion, the second portion remaining stationary in operation. At least one monochromatic light source is included, providing light directed from the brushhead in a direction substantially the same as the bristle tufts, such that the light impinges on the area of skin of the user acted on by the oscillating brushhead.

Abstract: An apparatus and process using a high-power, short-pulsed thulium laser to output infrared laser pulses delivered through an optical fiber, for cutting and ablating biological tissue. In some embodiments, the pulse length is shortened sufficiently to keep inside the stress-confined ablation region of operation. In some embodiments, the pulse is shortened to near the stress-confined ablation region of operation, while being slightly in the thermal-constrained region of operation. In some embodiments, the laser is coupled to a small low-OH optical fiber (˜100 ?m diameter). In some embodiments, the device has a pulse duration of about 100 ns for efficient ablation; however in some embodiments, this parameter is adjustable.

Abstract: A system for interfacing a surgical laser with an eye includes a first sensing element to couple to an output surface of the laser, an interface lens having second sensing element coupled to a first surface of the interface lens, and a detector coupled to the first sensing element. A second surface of the interface lens contacts the eye. The detector determines when the first sensing element contacts the second sensing element. A method for aligning the laser with the eye includes coupling the laser to the patient interface, sensing an electrical change indicating a position of the output surface with the interface lens, comparing the electrical change with a predetermined value to produce a correction, and re-positioning the laser with the correction.

Abstract: The present invention relates to a device for administering electromagnetic radiation to human tissue, in particular light to skin. The device comprises a treatment head with a recess (10) in which the light is emitted and in which the air pressure may be decreased by a pump (11). The device also comprises a pressure gauge (8) for measuring the pressure in the recess (10). Above a certain threshold value the device will not function, because this indicates an incorrect positioning of the device on the skin, which might cause harm to persons. By providing the pressure gauge (8), an operator may determine whether the positioning of the treatment head is correct. The device is advantageously automated in that the pressure gauge (8) is connected to control means (5) for controlling the source (3) of radiation.

Abstract: There is provided a system, apparatus and methods for developing laser systems that can create precise predetermined clear corneal incisions that are capable of reducing induced astigmatism. The systems, apparatus and methods further provide laser systems that can provide these incisions at or below Bowman's membrane.