Cyrogenic Application Patents (Class 606/20)
-
Patent number: 9808304Abstract: An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.Type: GrantFiled: November 9, 2016Date of Patent: November 7, 2017Assignee: Medtronic CryoCath LPInventor: Jean-Pierre Lalonde
-
Patent number: 9724492Abstract: A lumen extension member is provided for a catheter having a catheter body and an elongate electrode coupled to the catheter body. The elongate electrode defines an electrode lumen extending therethrough. The lumen extension member is positioned within the electrode lumen and is coupled to the catheter body. The lumen extension member includes a tubular member including a sidewall and at least one opening that extends through the sidewall.Type: GrantFiled: February 3, 2015Date of Patent: August 8, 2017Assignee: ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.Inventors: Alan de la Rama, Cary Hata, William Du, Yongxing Zhang
-
Patent number: 9668800Abstract: A system for alleviating spasticity of a skeletal muscle having an associated motor nerve. The system may include a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween. The needle is configured for insertion proximate to the nerve. A cooling fluid supply lumen can extend distally within the needle lumen to a distal portion of the needle lumen. A cooling fluid source is couplable to the cooling fluid supply lumen to direct cooling fluid flow into the needle lumen. A controller having at least one processor configured to implement a spasticity treatment algorithm for controlling the cooling fluid source so that liquid from the cooling flow vaporizes within the needle lumen to provide a treatment phase to the motor nerve such spasticity of the skeletal muscle is mitigated.Type: GrantFiled: March 18, 2014Date of Patent: June 6, 2017Assignee: MYOSCIENCE, INC.Inventors: Jwala Karnik, Clint Carnell, Jesse Rosen, John Allison
-
Patent number: 9668671Abstract: Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body.Type: GrantFiled: September 28, 2015Date of Patent: June 6, 2017Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, AEGIS MEDICAL INNOVATIONS INC.Inventors: Paul A. Friedman, Charles J. Bruce, Samuel J. Asirvatham, Trevor A. McCaw, Elliot Y. K. Hong
-
Patent number: 9662162Abstract: An ablation device comprising an ablation applicator adapted for ablating material from an object upon delivery of an ablation medium to the ablation applicator in an ablation mode, an ablation medium supply line adapted for supplying the ablation medium to the ablation applicator in the ablation mode, an ablation medium drain line adapted for draining the ablation medium received from the ablation applicator in the ablation mode, and a closure mechanism adapted for selectively enclosing a predefined volume in a fluidic path upon operating the ablation device in a no-flow mode or upon detecting a leak in the fluidic path, the fluidic path including the ablation applicator and being defined between the ablation medium supply line and the ablation medium drain line.Type: GrantFiled: May 31, 2011Date of Patent: May 30, 2017Assignee: AFreeze GmbHInventors: Gerald Fischer, Florian Hintringer
-
Patent number: 9610112Abstract: A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.Type: GrantFiled: March 18, 2014Date of Patent: April 4, 2017Assignee: MYOSCIENCE, INC.Inventors: Jwala Karnik, Jason Reynolds, John Allison, Clint Carnell
-
Patent number: 9603650Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session.Type: GrantFiled: March 7, 2016Date of Patent: March 28, 2017Assignee: Channel Medsystems, Inc.Inventors: Daniel R. Burnett, Ric Cote, William W. Malecki, Brian M. Neil, David Beaulieu, Benjamin D. Voiles
-
Patent number: 9549772Abstract: The present invention relates to devices and methods for altering the tissue in and around an intervertebral disc through localized hypothermia therapy to restore function of the disc and reduce pain. Hypothermia therapy is defined as the reduction of tissue temperature to below that of the equilibrium temperature. Target therapeutic temperatures and times are varied according to the desired treatment effect. Intended effects of hypothermia of the intervertebral disc include cellular disruption leading to cell death and or structural and chemical denaturation within the anulus fibrosus, nucleus pulposus, or nerve fibers, temporary or permanent deadening of the nerves within or surrounding the disc, induction of a healing response, angiogenesis, or accelerated degeneration and/or drying of the nucleus pulposus and/or anulus fibrosus. Various effects can be achieved by reaching different temperatures for differing periods of time or by the proximity of the hypothermia therapy device to the treatment target.Type: GrantFiled: June 26, 2014Date of Patent: January 24, 2017Inventor: Allen Carl
-
Patent number: 9510888Abstract: An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.Type: GrantFiled: November 4, 2015Date of Patent: December 6, 2016Assignee: Medtronic CryoCath LPInventor: Jean-Pierre Lalonde
-
Patent number: 9480521Abstract: A mapping catheter includes an elongated body for inserting into patient vasculature. A distal end of the elongated body includes a distal portion that includes a plurality of electrodes, a proximal portion disposed proximal to the distal portion, and a reduced-dimension portion disposed between the proximal and distal portions. The distal end is formed, at least in part, from a memory shape material that bends into a preformed shape upon release from a confined space. The preformed shape includes a first loop formed, at least in part, by the distal portion. The first loop is transverse to a longitudinal axis of the proximal portion. The reduced-dimension portion is configured and arranged to bend such that the reduced-dimension section advances distally through the first loop when the first loop is held in a fixed position and a force is applied distally along the longitudinal axis of the proximal portion.Type: GrantFiled: May 20, 2014Date of Patent: November 1, 2016Assignee: Boston Scientific Scimed, Inc.Inventors: Isaac Kim, Josef V. Koblish, David McGee
-
Patent number: 9439709Abstract: A cryoablation system has a catheter that receives working cryogen, the catheter having a catheter body that has a distal section having a freezing element which delivers the working cryogen to a treatment location, and a balloon enclosing the freezing element. The catheter body includes an outer tube that has two delivery tubes and a guide wire tube positioned inside the outer tube.Type: GrantFiled: January 31, 2014Date of Patent: September 13, 2016Assignee: Cryofocus Medtech (Shanghai) Co., Ltd.Inventors: Thach Buu Duong, Min Frank Zeng
-
Patent number: 9408655Abstract: A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.Type: GrantFiled: October 27, 2011Date of Patent: August 9, 2016Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, William Nydam
-
Patent number: 9402675Abstract: A tweezers device for the application of cryogenic matter directly on a skin lesion while protecting the collateral skin tissue from being damaged by the cryogenic matter, the device comprising an applicator body configured with opposing tweezer arms, each tweezer arm including a cryogenic matter application element such that when the opposing tweezer arms are closed about the skin lesion, the skin lesion is substantially encased by the cryogenic matter application elements.Type: GrantFiled: February 3, 2011Date of Patent: August 2, 2016Assignee: TUVIDERM LLCInventor: Zecharia Lind
-
Patent number: 9402676Abstract: Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.Type: GrantFiled: August 26, 2011Date of Patent: August 2, 2016Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, Barron Nydam, William Nydam
-
Patent number: 9400499Abstract: Systems and methods for integrating quantum computing systems into mobile systems for the purpose of providing real-time, quantum computer-based control of the mobile systems are described. A mobile system includes a data extraction subsystem that extracts data from an external environment of the mobile system and a quantum computing subsystem that receives data from the data extraction subsystem and performs a quantum computing operation in real-time using the data from the data extraction subsystem. A result of the quantum computing operation influences a behavior of the mobile system, such as the navigation of the mobile system or an action performed by the mobile system. The on-board quantum computing subsystem includes on-board quantum computing infrastructure that is adapted to suit the needs and spatial constraints of the mobile system.Type: GrantFiled: October 2, 2015Date of Patent: July 26, 2016Assignee: D-WAVE SYSTEMS INC.Inventors: Colin P. Williams, Jeremy P. Hilton
-
Patent number: 9345527Abstract: A system and a method for its use are provided to cool a cryotip at the distal end of a probe for a cryosurgical procedure. In particular, the cryotip is cooled by a liquid refrigerant to cryogenic temperatures in order to perform a cryosurgical procedure on biological tissue. The system is closed-loop, and during transit of the liquid refrigerant through the entire system, the liquid refrigerant always remains in a liquid state at a relatively low pressure.Type: GrantFiled: November 9, 2011Date of Patent: May 24, 2016Assignee: CRYOMEDIX, LLCInventors: Alexei V. Babkin, Peter J. Littrup, William J. Nydam
-
Patent number: 9295512Abstract: A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.Type: GrantFiled: September 12, 2013Date of Patent: March 29, 2016Assignee: MyoScience, Inc.Inventors: John Allison, Richard Radnovich, Jason Reynolds
-
Patent number: 9277952Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session.Type: GrantFiled: October 10, 2014Date of Patent: March 8, 2016Assignee: Channel Medsystems, Inc.Inventors: Daniel R. Burnett, Ric Cote, William W. Malecki, Brian M. Neil, David Beaulieu, Benjamin D. Voiles
-
Patent number: 9243825Abstract: Cooling apparatus is provided which comprises a mechanical refrigerator and a heat pipe. The mechanical refrigerator has a first cooled stage and a second cooled stage, the second cooled stage being adapted to be coupled thermally with target apparatus to be cooled. The heat pipe has a first part coupled thermally to the first stage of the mechanical refrigerator and a second part coupled thermally to a cooled member which may comprise the second stage of the mechanical refrigerator. The heat pipe is adapted to contain a condensable gaseous coolant when in use. An example coolant is Krypton. The apparatus is operated in a first cooling mode in which the temperature of the cooled member causes the coolant within the second part of the heat pipe to be gaseous and the temperature of the first stage causes the coolant in the first part to condense, whereby the cooled member is cooled by the movement of the condensed liquid from the first part to the second part of the heat pipe.Type: GrantFiled: November 11, 2011Date of Patent: January 26, 2016Assignee: Oxford Instruments Nanotechnology Tools LimitedInventors: Vladimir Mikheev, Par G. Teleberg, Anthony Matthews, Justin Elford
-
Patent number: 9232197Abstract: An endoscope apparatus includes an imaging element, a flexible substrate, and a flexible heat release sheet. The imaging element is built in an endoscope front end portion so as to receive incident light from a subject. The imaging element and components of a circuit for driving the imaging element are mounted on the flexible substrate and the flexible substrate is built in the endoscope front end portion. The flexible heat release sheet includes a first region attached to a given region of the imaging element other than a light receiving surface of the imaging element and a second region thermally contacted to a heat release member disposed in the endoscope front end portion.Type: GrantFiled: September 28, 2011Date of Patent: January 5, 2016Assignee: FUJIFILM CorporationInventor: Kazuhiko Nakamura
-
Patent number: 9204916Abstract: An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.Type: GrantFiled: October 27, 2011Date of Patent: December 8, 2015Assignee: Medtronic CryoCath LPInventor: Jean-Pierre Lalonde
-
Patent number: 9131975Abstract: Ablation devices useful for destroying nerve and soft tissue via a minimally invasive procedure to alleviate pain are provided. The device comprises a probe comprising an outer tube having an exterior surface comprising a tip and an interior surface that defines an internal passage. An inner tube is disposed within the outer tube and comprises an interior surface that defines an internal passage having a filament disposed therein. The filament has an opening configured to release a pressurized material into the interior surface of the probe so as to cool the exterior surface of the outer tube to a selected temperature. Disposal of the inner tube within the internal passage of the outer tube produces an air gap that surrounds the exterior surface of the inner tube, and the tip is configured for ablating nerve and/or soft tissue. Methods for ablating nerve and/or soft tissue utilizing the ablation devices are also provided.Type: GrantFiled: March 15, 2013Date of Patent: September 15, 2015Assignee: Warsaw Orthopedic, Inc.Inventor: William F. McKay
-
Patent number: 9101343Abstract: A cryoablation system has a gas source which provides a working gas at room temperature and at a constant set pressure. The system also includes a liquid generator which is coupled to the gas source to receive the working gas, and which then generates a working cryogen fluid in a liquid phase that operates at a temperature and pressure that lies on its Joule-Thomson Inversion Curve, with the Joule-Thomson coefficient maintained within the range 0.00±0.08 degrees F./Atmosphere. The system also includes a catheter coupled to the liquid generator for receiving the working cryogen, the catheter having a distal section which delivers the working cryogen to a treatment location.Type: GrantFiled: August 3, 2012Date of Patent: August 11, 2015Inventors: Thach Buu Duong, Min Frank Zeng
-
Patent number: 9050069Abstract: The present invention provides a medical system, including a catheter defining an injection lumen, a chamber in fluid communication with the injection lumen, and an exhaust lumen in fluid communication with the chamber; a first temperature sensor positioned in the exhaust lumen proximal to the chamber; a second temperature sensor positioned in the chamber; and a console in electrical communication with the first and second temperature sensors, the controller modifying coolant flow through the medical device based at least in part upon a signal received from the first and second temperature sensor. The system may further include a thermally-conductive element circumscribing a substantial portion of the exhaust lumen proximal to the chamber, where the first temperature sensor is mounted to the thermally-conductive element, and the thermally-conductive element may include at least one of a braid, coil, and band.Type: GrantFiled: May 16, 2008Date of Patent: June 9, 2015Assignee: Medtronic CryoCath LPInventors: Jean-Pierre Lalonde, Dan Wittenberger, Marwan Abboud, Constantin Bogdan Ciobotaru, Ramin Sabbaghe-Kermani
-
Patent number: 9039688Abstract: A method for cryogenically treating a target tissue comprises providing a cryogenic device having one or more tissue penetrating needle probes, and advancing the one or more tissue penetrating needle probes through skin disposed above the target tissue into the target tissue. The target tissue comprises a motor nerve. The method also includes cooling the target tissue with the one or more tissue penetrating needle probes, and temporarily disrupting signal conduction from the motor nerve thereby preventing contraction of a muscle operably coupled to the motor nerve. This reduces or eliminates hyperdynamic wrinkles of a patient's face.Type: GrantFiled: December 13, 2011Date of Patent: May 26, 2015Assignee: MyoScience, Inc.Inventors: Francis R. Palmer, III, Michael Hsu, Kristine Tatsutani
-
Patent number: 9039687Abstract: A method of assessing lesion quality of an ablated tissue region comprising ablating at least a portion of the tissue region. The reactance of the ablated tissue region is measured at a plurality of frequencies. The lesion quality of the ablated tissue region is determined based on the measured reactance. For example, an untreated tissue reactance value and a predetermined thermally treated tissue region reactance threshold may be determined. The measured reactance at each of the plurality of frequencies is compared to the threshold to determine the lesion quality of the thermally treated tissue region. The thermal treatment of the tissue may be modified based on the lesion quality determination.Type: GrantFiled: October 28, 2010Date of Patent: May 26, 2015Assignee: Medtronic Ablation Frontiers LLCInventors: Catherine R. Condie, Kathryn Elaine Kasischke, Marshall L. Sherman
-
Patent number: 9011420Abstract: A method of operating a medical system, including coupling a medical system to an outlet of a fluid distribution network having a plurality of fluid outlets in a patient treatment center; delivering fluid from the outlet to the medical system; compressing the delivered fluid with the medical system; decreasing the moisture content of the delivered fluid with the medical system; cooling the fluid with the medical system; delivering the fluid from the medical system to a medical device; and removing the fluid from medical device with the medical system.Type: GrantFiled: October 27, 2010Date of Patent: April 21, 2015Assignee: Medtronic CryoCath LPInventor: Jean-Pierre Lalonde
-
Publication number: 20150105701Abstract: The invention provides a therapeutic system comprising: a console, wherein the console comprises a controller and an energy generator; a therapeutic device comprising: an operational head configured for transmitting the energy output from to a biological tissue; and a memory device comprising control instructions, wherein said control instructions comprise instructions for controlling the console; a reversible memory operable linkage linking the memory device to the controller; and a reversible connector configured for operably linking the energy generator to the operational head. Optionally, the energy generator is a generator of ablation energy or heat energy (e.g. RF generator) and the control instructions comprise instructions for controlling the output of the energy generator. Optionally, the control instructions comprise one or more parameters of energy output or an algorithm configured for controlling the energy output.Type: ApplicationFiled: September 24, 2014Publication date: April 16, 2015Inventors: Carl Mayer, John Ellenz
-
Publication number: 20150099976Abstract: System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a nerve bundle, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy.Type: ApplicationFiled: October 20, 2014Publication date: April 9, 2015Inventors: Roozbeh Ghaffari, Bassel de Graff, Gilman Callsen, William J. Arora, Benjamin Schlatka, Eugene Kuznetsov
-
Patent number: 8998888Abstract: A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen. The cryogenic medical device promotes the subcooling to any external cryogenic instrument.Type: GrantFiled: June 23, 2010Date of Patent: April 7, 2015Assignee: Endocare, Inc.Inventors: John M. Baust, John G. Baust, Roy Cheeks, Anthony Robilotto, Kristi Snyder
-
Publication number: 20150094700Abstract: There are provided an external cylinder for a probe equipped in a cryosurgical apparatus and a therapeutic-device unit, which are able to protect normal cells near a lesion, provide higher heat efficiency for the freeze and thawing, and simplify the structure. The external cylinder for the probe equipped in the cryosurgical apparatus and the therapeutic-device unit which includes the external cylinder for the probe equipped in the cryosurgical apparatus are provided. The external cylinder includes a given range in which the freezing gas enables an ice ball to be formed on an outer circumference including the distal end portion; and adiabatic means arranged in a range other than the given range so as to prevent heat from being exchanged between the inner space and an outside.Type: ApplicationFiled: December 27, 2012Publication date: April 2, 2015Inventor: Kansei Iwata
-
Patent number: 8992516Abstract: A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and at least one coolant delivery element. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery elements are in communication with the coolant supply and are operable to deliver a micro-controlled pulse of coolant to the distal end.Type: GrantFiled: September 10, 2007Date of Patent: March 31, 2015Assignee: Avedro, Inc.Inventor: David Muller
-
Publication number: 20150088108Abstract: Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument via a probe driver, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient. The probe driver allows for precise positioning, stabilization and manipulation of a probe.Type: ApplicationFiled: December 1, 2014Publication date: March 26, 2015Applicant: MONTERIS MEDICAL CORPORATIONInventors: Richard TYC, Salman QURESHI, Mark Andrew GRANT, Luis Filipe Silva FERNANDES, Daniel Prazeres CARREIRA, John SCHELLHORN
-
Publication number: 20150087975Abstract: A method of monitoring the cryoablation of a target volume of tissue with ultrasound elastography, the method comprising acquiring a first elastography image encompassing said target volume of tissue, performing at least one cycle of freezing and thawing of tissue encompassed in said target volume, acquiring a second elastography image encompassing said target volume, and comparing said first and said second elastography images over said target volume. The elastography provides either relative or quantitative measurements of tissue elasticity. The elastography maps of tissue elasticity, before and after cryoablation of one region, can guide the cryoablation of another region. The use of elastography provided feedback to the operator to achieve effective treatment with cryoblation over a planned target.Type: ApplicationFiled: September 24, 2013Publication date: March 26, 2015Applicant: UNIVERSITY OF BRITISH COLUMBIAInventors: Septimiu Salcudean, Caitlin Schneider, Diego Dall'Alba, Robert Rohling, Christopher Nguan
-
Patent number: 8961506Abstract: Methods and systems for treating tissue that employ a radiometer for temperature measurements and use feedback from the radiometer to regulate energy being applied to the tissue are provided. For example, methods and systems are provided for calculating temperature based on signal(s) from a radiometer, which may provide useful information about tissue temperature at depth, and automatically regulating energy applied to the tissue based on the tissue temperature.Type: GrantFiled: May 9, 2014Date of Patent: February 24, 2015Assignees: Advanced Cardiac Therapeutics, Inc., Meridian Medical Systems, LLCInventors: John McCarthy, Timothy J. Lenihan, Eric R. Kanowsky, Robert C. Allison
-
Patent number: 8951246Abstract: A cryosurgical device, with a control for the supply and/or removal of a coolant gas to a cryoprobe via a return flow or a supply flow. The device has at least one socket for the attachment of a rigid cryoprobe and a flexible cryoprobe. The socket and the plugs of the cryoprobes each form probe couplings. The configuration of the cryosurgical device allows both rigid and flexible cryoprobes to be automatically connected to the appropriate return flow conduit, independently of the level of knowledge of operating personnel.Type: GrantFiled: November 22, 2006Date of Patent: February 10, 2015Assignee: Erbe Elektromedizin GmbHInventor: Franz Geiselhart
-
Patent number: 8945106Abstract: A cryogenic probe design is provided containing, for example, an inner coil injection tube with a continuous flow of circulating liquid and an outer jacket enclosing the inner coil injection tube. A transducer may monitor parameters in the region between the inner coil injection tube and the outer jacket. An outer jacket serves to prevent gas leakage. One or more embodiments of a probe design provide continuous flow for example via a continuous and controlled path from inlet to outlet and an expanded thermally transmissive region. Expanding a thermally transmissive region of the cooling zone may be provided, for example, in one or more embodiments of injection tube designs.Type: GrantFiled: July 2, 2009Date of Patent: February 3, 2015Inventors: Steve Arless, Daniel Nahon, Domenic Santoianni
-
Patent number: 8939968Abstract: A cryosurgical instrument, comprising a cryoprobe having ducting through which a compressed cooling fluid, such as a cooling gas, flows, for cooling a least part of the cryoprobe. The ducting has an expansion channel having a channel cross-section that enlarges progressively in the flow, direction over a predetermined length such that the compressed cooling gas gradually decompresses, at least partially, beyond a predetermined length on its flow path through the expansion channel while simultaneously cooling down.Type: GrantFiled: February 11, 2009Date of Patent: January 27, 2015Assignee: Erbe Elektromedizin GmbHInventor: Franz Geiselhart
-
Publication number: 20150025513Abstract: A system and method for providing treatment feedback for a thermal treatment device (100) is provided. In certain embodiments, a thermal transmitter (120) is configured to apply an amount of thermal energy (104) to a target site (106), the thermal energy having a selected frequency and a selected power level for penetration to a depth beneath the surface of the skin. A thermal imager (140) is also provided, the thermal imager (140) being configured to capture thermal data and thermal images of the target site. The device may further provide a thermal display (160) configured to display the thermal images and thermal data, providing feedback to a user (201).Type: ApplicationFiled: October 8, 2014Publication date: January 22, 2015Inventor: Farhan Taghizadeh
-
Publication number: 20150011488Abstract: Epicatechins, Epicatechin Oligomers, or Thiolated Epicatechins are applied (A) directly to a genital wart in the form of a cream, ointment, paste or solution, (B) directly to the genital wart wherein such cream, ointment, paste or solution contains as an additional active ingredient a skin permeabilizing agent, (C) following electrosurgical resection or removal of the genital wart in such form of a cream, ointment, paste or solution, (D) following chemical resection or extirpation of the genital wart in such form, (E) following surgical resection or removal of the genital wart in such form, wherein said Epicatechins, Epicatechin Oligomers, or Thiolated Epicatechins both provide antiviral activity against multiple strains of human pappilomavirus (HPV) and promote healing following resection polymers contained in a vehicle. Disclosed are the compositions, therapeutical kits containing such composition, methods of treatment using such composition, and methods of enhancing the stability of such composition.Type: ApplicationFiled: March 10, 2014Publication date: January 8, 2015Applicant: CACAO BIO-TECHNOLOGIES, LLCInventors: Daniel PRESTON, Randall B. MURPHY
-
Publication number: 20140364842Abstract: A medical method is provided, including a medical device having a distal assembly including at least one electrode and at least one treatment element, the medical device generating information regarding at least one of a physiological measurement and an operational parameter of the medical device; a plurality of surface electrodes affixable to a skin of the patient, wherein the surface electrodes are in electrical communication with the distal assembly to obtain position information of the medical device; and a processor pairing the position information and the at least one of a physiological measurement and an operational parameter of the medical device.Type: ApplicationFiled: August 26, 2014Publication date: December 11, 2014Inventors: Randell L. WERNETH, Marshall SHERMAN, Mark T. STEWART, J. Christopher FLAHERTY
-
Publication number: 20140364841Abstract: An applicator for treating lipid-rich cells disposed under a cutaneous layer includes a vacuum cup defining an interior cavity. The vacuum cup has a first concave contour that defines a mouth of the interior cavity. At least a first cutout extends through a first sidewall of the vacuum cup. At least a first cooling unit is disposed in the first cutout. The cooling unit has a second concave contour. The cooling unit is configured for heat transfer with respect to the lipid-rich cells when the first and second contours engage the cutaneous layer.Type: ApplicationFiled: November 14, 2012Publication date: December 11, 2014Inventor: Andrew Kornstein
-
Patent number: 8906005Abstract: A cryo-surgical system may comprise a container containing a refrigerant, a delivery tube having a first end configured to be in flow communication with the container and a second end opposite the first end. The system may further include a plurality of flexible finger portions disposed proximate a second end of the delivery tube opposite the first end, an applicator bud having a body portion disposed within the plurality of flexible finger portions and a contact surface extending from the plurality of flexible finger portions. An adjustment ring may be disposed along the delivery tube adjacent to the plurality of flexible finger portions. The contact surface of the bud may be changeable by adjustment of the adjustment ring.Type: GrantFiled: June 11, 2009Date of Patent: December 9, 2014Assignee: Orasure Technologies, Inc.Inventor: Philip Michael Formica
-
Patent number: 8900222Abstract: A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.Type: GrantFiled: January 25, 2013Date of Patent: December 2, 2014Assignee: Medtronic Cryocath LPInventors: Marwan Abboud, Rachid Mahrouche, Chadi Harmouche, Teresa Ann Mihalik, Giles Desrochers
-
Patent number: 8888768Abstract: A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.Type: GrantFiled: April 29, 2010Date of Patent: November 18, 2014Assignee: CryoMedix, LLCInventors: Alexei Babkin, Peter Littrup, William Nydam, Barron Nydam
-
Patent number: 8882755Abstract: A novel medical probe assembly, system, and methods for the use thereof to treat tissue are described. The system optionally comprises an energy source, two probe assemblies, and one or more cooling devices to provide cooling to at least one of the probe assemblies. The probe assemblies may be configured in a bipolar mode, whereby current flows preferentially between the probe assemblies. The probe assemblies and system described herein are particularly useful to deliver radio frequency energy to a patient's body. RF energy delivery may be used for various applications, including the treatment of pain, tumor ablation and cardiac ablation.Type: GrantFiled: April 14, 2005Date of Patent: November 11, 2014Assignee: Kimberly-Clark Inc.Inventors: Mark Leung, Krishan Shah, Laura Conquergood, Subashini Chandran
-
Publication number: 20140316393Abstract: Systems and methods that enable delivery of radiofrequency energy and cryotherapy applications to adipose tissue for reduction and contouring of body fat are described herein. Aspects of the disclosure are directed to methods for reducing surface irregularities in a surface of a subject's skin resulting from an uneven distribution of adipose tissue in the subcutaneous layer. The method can include delivering capacitively coupled or conductively coupled radiofrequency energy to a target region of the subject at a frequency which selectively heats fibrous septae in a subcutaneous layer of the target region to a maximum temperature less than a fibrous septae denaturation temperature. Furthermore, the method can include removing heat such that lipid-rich lobules in the subcutaneous layer are affected while non-lipid-rich cells and lipid-rich regions adjacent to the fibrous septae are not substantially affected.Type: ApplicationFiled: February 20, 2014Publication date: October 23, 2014Applicant: Zeltiq Aesthetics, Inc.Inventor: Mitchell E. Levinson
-
Publication number: 20140316385Abstract: Methods of treating a subject for a cardiac arrhythmia are provided. Aspects of the methods include thoracoscopically producing a cardiac Cox maze III set of lesions in cardiac tissue of the subject in a manner sufficient to treat the subject for the cardiac arrhythmia.Type: ApplicationFiled: November 22, 2013Publication date: October 23, 2014Inventor: James Longoria
-
Patent number: 8864757Abstract: A contact sensing assembly including a catheter including an electrode having a base portion mounted adjacent a head portion of the catheter body. A sensor is disposed adjacent the base portion for measuring compression or tensile forces applied to an electrode tip portion, and includes a predetermined sensitivity. The base and head portions include predetermined rigidity so that forces applied to the electrode tip portion are determinable as a function of the sensitivity and a sensor output. A contact sensing assembly also includes an electrode pipe operatively connected to the catheter body for movement and bending with the catheter body, and an electrode wire disposed in the electrode pipe and including insulation. A change in capacitance resulting from movement of the electrode wire toward the electrode pipe or contact of the electrode wire with the electrode pipe during bending of the catheter correlates to a force applied to the catheter.Type: GrantFiled: December 31, 2008Date of Patent: October 21, 2014Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.Inventors: Gleb V. Klimovitch, John W. Sliwa
-
Publication number: 20140309628Abstract: A system and method for treating the skin by heating at least one discrete skin volume, comprising at least one treatment tip reversibly connectable to at least one applicator. The treatment tip comprises one or more electrodes, with the electrodes having one or more spaced apart protruding conducting elements. The protruding conducting elements are characterized by dimensions of height A and hypotenuse B, where the ratio A/B is in a predetermined range, and the protruding conducting elements penetrate the skin surface at discrete locations. The electrodes are configured to apply energy to skin volumes around the discrete locations so as to heat the skin volumes. The applicator comprises an energy generator configured to apply energy to the skin volumes by means of the electrodes and the spaced apart protruding conducting elements.Type: ApplicationFiled: April 14, 2014Publication date: October 16, 2014Applicant: VENUS CONCEPT LTD.Inventors: Boris VAYNBERG, Yotam ZIMMERMAN