Abstract: Lighting devices for providing a secondary light with high luminance are provided. The lighting devices include a light conversion element and a light emitting unit with a light source that emits a primary light. The light conversion element has a front side illuminated with the primary light and, in response to the primary light, to emit a secondary light from the front side. The secondary light has a larger wavelength than the primary light.

Abstract: A cardiac activity measurement assembly for a sports equipment handle and the handle is disclosed, wherein the assembly includes an optical cardiac activity sensor configured to measure cardiac activity of a user, and an attachment element for floatingly attaching the optical cardiac activity sensor to a handle of sports equipment in order to reduce pressure on a measuring head of the sensor caused by a skin contact between the measuring head and at least one finger or a palm of the user when gripping the handle.

Abstract: A laser beam irradiation apparatus including: a plurality of laser light sources emitting first laser beams; and a light-condensing optics system having an incident face on which the first laser beams are made incident and performing an optical operation on the first laser beams to emit second laser beams. The plurality of laser light sources are configured to emit the first laser beams so that beam diameters are expanded towards the incident face. Each first laser beam overlaps at least one of the other laser beams on the incident face. The light-condensing optics system is configured so that beam diameters of second laser beams emitted from the light-condensing optics system are minimal on a target face, and a distance between a center of each second laser beam and the optical axis on the target face is smaller than a beam radius of each second laser beam on the target face.

Abstract: A light emitting device for a human having a scalp with hair, the device includes a flexible arcuate base configured to contour a portion of the scalp. The base has a width between 20 mm and 120 mm and includes an interior and an interior surface. At least one array of teeth is coupled to the interior surface, each tooth in the at least one array of teeth being pressed against the scalp when the base is contoured about the scalp. Each tooth is configured to part the hair when the at least one array of teeth is pressed against the scalp. An array of at least one of light emitting diodes and laser diodes coupled to the base proximate the at least one array of teeth.

Abstract: Intraocular pressure in an eye is reduced by delivering a high resolution optical coherence tomography (OCT) beam and a high resolution laser beam through the cornea, and the anterior chamber into the irido-corneal angle along an angled beam path. The OCT beam provides OCT imaging for surgery planning and monitoring, while the laser beam is configured to modify tissue or affect ocular fluid by photo-disruptive interaction. In one implementation, a volume of ocular tissue within an outflow pathway in the irido-corneal angle is modified to create a channel opening in one or more layers of the trabecular meshwork. In another implementation, a volume of fluid in the Schlemm's canal is affected by the laser to bring about a pneumatic expansion of the canal. In either implementation, resistance to aqueous flow through the eye is reduced.

Abstract: [Object] To provide an ablation system capable of suppressing heat damages to the lumen intima. [Solution] An ablation system 10 has an ablation device 11 in which a balloon 21 is provided on the distal end side of a shaft 22 and an in-side tube 27 causing a fluid to flow into the balloon 21, the internal space of the shaft 22 causing a fluid to flow out of the balloon 21, and an optical fiber 29 guiding laser light into the balloon 21 are individually provided along the shaft 22, a laser light generating unit 12 emitting laser light to the optical fiber 29, and a fluid returning unit 13 returning a fluid into the internal space of the balloon 21. The ablation device 11 has a reflector 33 reflecting laser light emitted from the optical fiber 29 in the balloon 21, in which the reflector 33 is movable along the axial direction 191 in the balloon 21 and is rotatable in the axial direction 101 as the axis line.

Abstract: A treatment method for a variety of neurological conditions using a novel combination of near infrared (NIR) light therapy and the pharmacological agent ketamine. After administration of ketamine to a patient, NIR is aimed through the scalp at the brain, preferably targeted at the brain regions most affected. In addition, certain dietary supplements and an exercise program may be offered. Combined, these therapies have proved much more effective than the sum of their individual efficacies.

Abstract: Dermatological systems and methods for providing a therapeutic laser treatment wherein the duration of a therapeutic laser pulse is based on one or more determinations of a surface temperature of the skin during the delivery of the pulse. Initiation of the therapeutic laser pulse may be based on sensed skin temperature during a cooling of the skin prior to initiation of the pulse.

Abstract: Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with the capability of switching between a modelocked pulse operating mode and an amplification operating mode. The operating modes are carried out through the application of a time-dependent bias voltage, having waveforms as described herein, to an electro-optical device (e.g., a Pockels cell) positioned along the optical axis of the resonator.

Abstract: A system and method for increasing the amplitude of accommodation and/or changing the refractive power and/or enabling the removal of the clear or cataractous lens material of a natural crystalline lens is provided. Generally, the system comprises a laser, optics for delivering the laser beam and a control system for delivering the laser beam to the lens in a particular pattern. There is further provided a device for determining the shape and position of the lens with respect to the laser. There is yet further provided a method and system for delivering a laser beam in the lens of the eye in a predetermined shot pattern that utilize as series of shots that form a shell cut, a partial shell cut, a laser suture cut and/or a volumetric shaped removal, which essentially following the shape of a suture layer of the lens.

Abstract: A surgical instrument is configured to concurrently dissect and coagulate tissue. The surgical instrument includes a handle and a shaft extending distally from the handle. The shaft includes an outer hypotube, a lumen coaxially-disposed within the hypotube and extending beyond a distal end thereof, a coaxial feedline coaxially-disposed within the lumen, and having an inner conductor and an outer conductor disposed coaxially about the inner conductor, and a coolant tube coaxially-disposed between the lumen and the coaxial feedline to form an inflow conduit and an outflow conduit. The instrument further includes a dissecting head assembly coupled to a distal end of the shaft. The dissecting head assembly includes a dielectric core having a substantially planar radiating surface and at least one non-radiating surface, a reflective coating disposed on the at least one non-radiating surface of the dielectric core, and a blade extending from the radiating surface.

Abstract: A Computer program for determining a working profile for controlling a radiation system in refractive eye surgery, said program comprising: a user interface for input of data by a user; a data receiving interface for receiving measured data regarding the eye to be corrected; a working profile generator for generating a working profile on the basis of the input data and measured data; a generator for generating control data for controlling electromagnetic radiation; a simulator for simulating a treatment result on the basis of said control data for controlling the electromagnetic radiation and the effect of said radiation on eye tissue; a judgment stage for judging said treatment results by applying pre-given criteria; an iteration loop for generating iteratively, in case of a negative judgment, another amended profile on the basis of other data or for generating iteratively other control data for controlling the electromagnetic radiation; and a transfer means for transferring control data to a control of the

Abstract: A laser device for dermocosmetic, medical, or aesthetic treatments, comprising: A) a laser system comprising a lamp-pumped source; B) an optical fibre transporting the laser beam produced by said source; C) a handpiece or a scanner connected to said optical fibre, comprising a lens and mirror system projecting the image of the laser beam onto the area to be treated; characterized in that said optical fibre has a rectangular section and said image is rectangular. A method of dermocosmetic laser treatment characterized by rectangular laser spots is also claimed. It is a further object of the present invention a tracing kit, which allows the marking of a surface area, preferably of biological tissue, with a fluorescent or photosensitive substance invisible to light. Such an invisible and fluorescent or photosensitive substance absorbs the electromagnetic radiation with the proper wavelength emitted by the illuminator and reflects it in the visible spectrum.

Abstract: A method for cosmetically treating skin tissue is disclosed in which a combination of laser energy and RF energy is applied to the skin tissue. In the method, a microchannel is first formed in the skin tissue having a length, a depth and a width by ablating the skin tissue. After that, RF electrodes are placed on the skin tissue on either side of the width dimension of the microchannel, followed by activation of RF energy to drive RF energy below the depth of the microchannel formed, and this the RF energy is driven deeper into the skin tissue than would have occurred in the absence of the microchannel.

Abstract: A cooling element includes a frame including one or more datums. The cooling element also includes a first window including a first proximal surface and a first distal surface. The first window is sealed to the frame. The cooling element further includes a second window sealed to the frame. The second window includes a second proximal surface and a second distal surface. The second window is configured to contact a target tissue or a tissue adjacent to the target tissue via the second distal surface. The cooing element also includes a coolant chamber located between the first distal surface of the first window and the second proximal surface of the second window and configured to receive a coolant. The first window, the second window and the coolant chamber are configured to receive and electromagnetic radiation (EMR), and transmit a portion of the received EMR to the target tissue.

Abstract: A method of laser irradiation for alleviating the physical symptoms associated with acute or chronic inflammatory conditions, which can include directing a laser beam from a laser unit in a continuous wave operation having a wavelength of approximately 1275 nm and a power output level in the range of from one (1) Watt up to and including 75 Watts on an inflamed area that is to be treated, such that the laser beam penetrates the inflamed area in the range of from 0.1 cm to 30 cm. In addition, the laser beam from the laser unit can be configured to activate intracellular photoreceptors, thereby initiating a cascade of secondary cellular metabolic effects and normalizing cellular activity towards homeostasis.

Abstract: A change in the response of the cornea to ultrasonic energy directed into the cornea is monitored during irradiation of the cornea to bring about corneal crosslinking. Because the change in ultrasonic response is correlated with the degree of crosslinking achieved, a desired degree of crosslinking can be achieved by terminating the irradiation when the change reaches a threshold. The change in ultrasonic response can be determined by taking a baseline measurement before irradiation and additional measurements during irradiation using the same ultrasonic transducer (47). The transducers may be carried on a device (30) resembling a contact lens which overlies the eye and which transmits the light used in the irradiation step to the eye.

Abstract: A laser instrument for therapy on the human eye, designed for surgery of the cornea, the sclera, the vitreous body or the crystalline lens, especially suitable for use in immediate succession with other instruments for eye diagnosis or eye therapy, in such a way that during the alternating use of the various instruments, the eye or at least the patient preferably remains in a predetermined position and alignment within one and the same treatment area.

Abstract: A sensory hologram system includes a holographic system generating a holographic image, a sensory imparting system augmenting the holographic image, a detector configured to detect a location of a target, and a processor synchronizing the holographic system and the sensory imparting system based on the location of the target.

Abstract: A method for transdermally treating selected tissue and/or for facilitating the release and/or differentiation of stem cells, including exposing the selected tissue to laser light having a wavelength between approximately 600 and 1400 nm, and maintaining such exposure of the selected tissue or bone to the laser light for a period of time sufficient to deliver a laser light dosage of at least 3 Joules/cm2 per treatment and maintaining such exposure for a period of time sufficient to deliver a laser light dosage of at least 1000 Joules per treatment within a 24 hour period of time. The method also includes upcollimating the laser light such that the laser delivers to the selected tissue a substantially coherent beam of laser light having a cross-sectional area of at least 5 cm2, and, further, delivering the laser light to a depth of at least 5 mm in the selected tissue.

Abstract: A system and method for treatment of skin including a treatment surface having numerous small energy emitting points for fractional skin treatment as well as negative pressure outlets. During a treatment, negative pressure from the outlets may exert a pulling force on an opposing tissue surface to bring the tissue into contact with the energy points.

Abstract: Methods and systems are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Some embodiments described apparatus and methods useful in photoablation of tissues. In some embodiments, a photoablation apparatus is used to perforate a tissue, forming an aperture into a space behind the tissue. Gases formed during a photoablation process can be used to pressurize the space behind the tissue to enhance patency of the space. In some embodiments the tissue is the trabecular meshwork of the eye and a wall of Schlemm's canal, and the space behind the tissue is a portion of the lumen of Schlemm's canal. In some embodiments, the method is useful in the treatment of glaucoma by improving outflow from the anterior chamber of the eye into Schlemm's canal, reducing intraocular pressure.

Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.

Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.

Abstract: Apparatus and methods of treating a hard lens region of an eye with a laser where one method includes identifying a boundary of the hard lens region, selecting a laser-parameter to enable a photodisruptive procedure in the hard lens region and to control a spreading of bubbles in the hard lens region, modifying a mechanical property of a posterior portion of the hard lens region in a proximity of the identified boundary by the photodisruptive procedure, and modifying a mechanical property of a portion anterior to the modified posterior portion of the hard lens region by the photodisruptive procedure. The laser bubbles can be applied to form incisions which are non transverse to an axis of the eye and intersect the lens fibers.

Abstract: Optical energy-based methods and apparatus for sealing vascular tissue involves deforming vascular tissue to bring different layers of the vascular tissue into contact each other and illuminating the vascular tissue with a light beam having at least one portion of its spectrum overlapping with the absorption spectrum of the vascular tissue. The apparatus may include two deforming members configured to deform the vascular tissue placed between the deforming members. The apparatus may also include an optical system that has a light source configured to generate light, a light distribution element configured to distribute the light across the vascular tissue, and a light guide configured to guide the light from the light source to the light distribution element. The apparatus may further include a cutting member configured to cut the vascular tissue and to illuminate the vascular tissue with light to seal at least one cut surface of the vascular tissue.

Abstract: A system and method are provided for minimally-invasive removal of fat from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt and liquefy fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.

Abstract: A method for precise working of material, particularly organic tissue, comprises the step of providing laser pulses with a pulse length between 50 fs and 1 ps and with a pulse frequency from 50 kHz to 1 MHz and with a wavelength between 600 and 2000 nm for acting on the material to be worked. Apparatus, in accordance with the invention, for precise working of material, particularly organic tissue comprising a pulsed laser, wherein the laser has a pulse length between 50 fs and 1 ps and with a pulse frequency of from 50 kHz to 1 MHz is also described.

Abstract: A method of treating a subcutaneous fat region is provided. The method includes generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm and delivering an average power density of less than or equal to about 2.3 W/cm2 of the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. The method also includes cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds. The method further includes causing necrosis of at least one fat cell in the subcutaneous fat region.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Systems and methods for reconfigurable handheld laser treatment systems are provided. In one embodiment, a reconfigurable handheld laser treatment system comprises: a base unit; a handset that includes a attachment chamber having an attachment aperture, and a laser source arranged to project optical energy into the attachment chamber, the handset coupled to the base unit; an attachment having an adapter interface compatible with insertion into the attachment chamber; a trigger sensor coupled to logic that controls activation of the laser array; and an attachment sensor arranged to detect insertion of the adapted interface into the attachment chamber through the attachment aperture. The logic enables activation of the laser array when the attachment sensor detects an authorized attachment inserted into the attachment aperture. The logic disables activation of the laser array when the attachment sensor fails to detect an authorized attachment inserted into the attachment aperture.

Abstract: An apparatus for operating a laser materials processing and measurement device with a controllable laser for generating a laser beam and beam control means for adjusting the focus zone of a controlled portion of the laser beam in three spatial directions comprises an interface for operating a bidirectional data transfer link with the laser and the beam control means, and user control means for inputting and displaying control commands or control command sequences and for monitoring and/or controlling operation and/or the operating state of the device. So that all the components of the apparatus may also be tested with regard to all functionalities, if the laser materials processing and measurement device is not operationally ready and/or not connected to the interface, according to the invention the apparatus comprises simulation means for simulating operation of the device and/or of the user control means.

Abstract: Sectioning tools that emit self-sterilizing radiation. In one approach, the radiation is ultraviolet and/or plasmonic.

Abstract: An apparatus having an excitation source that includes at least one laser diode and also having a handpiece with a disposable, bendable tip cannula is disclosed.

Abstract: System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

Abstract: A multi-wavelength laser apparatus and methods for laser ablation of tissue are described. The apparatus and methods utilize a laser source emitting at two or more wavelengths coupled to a fiberoptic laser delivery device and a laser driver and control system with features for protection of the laser delivery device, the patient, the operator and other components of the laser treatment system. A fiber tip protection system limits damage to the fiberoptic laser delivery device, thereby allowing the multi-wavelength laser to be operated in a tissue contact mode. The invention, which has broad medical and industrial applications, is described in relation to a method for treatment of benign prostatic hyperplasia (BPH) by contact laser ablation of the prostate (C-LAP) using a technique of touch and pullback laser ablation of the prostate (TapLAP).

Abstract: The invention provides systems and method for the removal of diseased cells during surgery.

Abstract: An apparatus for ophthalmic procedures contains a source of aiming and treatment laser beams, folded mirrors and lens arrays to cause the formation of a static pupil on a delivery mirror for observation and treatment by an operator of the apparatus.

Abstract: A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal.

Abstract: A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, an optic fiber, and an optic fiber sleeve. The housing tube may have a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater that the first stiffness. The optic fiber may be disposed within an inner bore of the handle, the optic fiber sleeve, the actuation structure, and the housing tube. The optic fiber sleeve may enclose at least a portion of the optic fiber and the optic fiber sleeve may be disposed within the actuation structure and the housing tube. A compression of the actuation structure may be configured to curve the housing tube and the optic fiber.

Abstract: A method for endoscopic treatment that performs treatment under an endoscope includes irradiating a subject with first narrow band light having a predetermined peak wavelength, performing mucosal incision on a living tissue after irradiation with the first narrow band light, radiating second narrow band light having a peak wavelength in spectral characteristics in a wavelength band closer to a long wavelength side than the first narrow band light after the mucosal incision, and performing treatment other than the mucosal incision on the living tissue after radiation of the second narrow band light.

Abstract: Devices and methods are discussed directed to the use of a low profile laser ablation catheter for use in laser ablation removal of arterial plaque blockages to restore blood flow in the treatment of arteriovenous fistulas. Also discussed are devices and methods directed to packaging, long term storage and sterilization of liquid core ablation catheters.

Abstract: Systems and methods for treating tissue by concentrating a laser emission to at least one depth at a fluence sufficient to create an ablation volume in at least a portion of the target tissue and controlling pulse width within the picosecond regime to provide a desired mechanical pressure in the form of shock waves and/or pressure waves.

Abstract: Certain exemplary embodiments of the present disclosure can provide an apparatus and method for generating at least one radiation can be provided. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range can be provided.

Abstract: A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collagen in the tissue wound and tissue surrounding the tissue wound. The pulsed laser has a pulse width of not more than picoseconds in order of magnitude to heat tissue surrounding the tissue wound and facilitate bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. The laser wavelength is in a range of between about 800 nm to about 2,700 nm.

Abstract: A medical apparatus (300, 400, 500, 600, 700) comprises a heating system (304) for heating a target zone (324) of a subject (320), wherein the energy density in a predefined volume is modeled (338) using a thermal model and a processor (330) for controlling (340) the heating system (304).

Abstract: An infrared fiber-optic device is able to monitor esophageal temperature during an ablation/cryoablation procedure over a volume of interest to sense whether the temperature is too high or too low. The device may include a plurality of optical fibers each with a wide angle lens collectively disposed circumferentially and longitudinally to cover the volume of interest, as the particular region over which undesirable temperature may not be known beforehand. In other examples, the device may include an embedded array of infrared sensors extending sufficiently to encompass a volume of interest. The device may be used as part of a feedback control to regulate and stop operation of the ablation/cryoablation procedure to prevent vessel damage.

Abstract: Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.

Abstract: Methods and apparatus for damaging hair follicles using a series of rapidly-delivered low-fluence pulses of coherent or incoherent light are disclosed herein. In some embodiments, the pulses of coherent or incoherent light have a wavelength or wavelengths primarily in the range between 750 nm and 1500 nm. In some embodiments, applied electromagnetic radiation comprising the rapidly-delivered low-fluence pulses is effective for concomitantly heating both the sub-dermal layer (i.e. the dermis) of the tissue and the hair follicles. In some embodiments, the thermal damaging of the hair follicles is useful for facilitating hair-removal.

Abstract: An apparatus and a method are provided for treating a targeted area of ocular tissue in a tissue-sparing manner comprising use of two or more therapeutic modalities, including thermal radiation source (such as an CW infrared fiber laser), operative in a wavelength range that has a high absorption in water, and photochemical collagen cross-linking (CXL), together with one or more specific system improvements, such as peri-operative feedback measurements for tailoring of the therapeutic modalities, an ocular tissue surface thermal control/cooling mechanism and a source of deuterated water/riboflavin solution in a delivery system targeting ocular tissue in the presence of the ultraviolet radiation. Additional methods of rapid cross-linking (RXL), are provided that further enables cross-linking (CXL) therapy to be combined with thermal therapy.