Abstract: The present application is directed to a device 1 for irradiating human or animal tissue, in particular nerves, with laser light. In order to obtain gentle and effective destruction of tissue, the device 1 comprises a laser light source L adapted to generate laser light in a wavelength between 690 nm and 710 nm, and a light guide 3 for guiding through the laser light. A first end 3a of the light guide 3 is coupled the laser light source L and a second end 3b of the light guide 3 is coupled to an applicator 2 adapted to apply the laser light to the tissue.

Abstract: An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency and similar procedures. One such device emits pulsed or continuous energy radially from an optical fiber with two or more emitting portions at its distal region for 360° radial (circumferential) emission in various portions of the vein. Each emitting section comprises a fiber with a truncated cone and a short fiber segment with a conical tip at the distal end of the fiber assembly. Different embodiments are presented which vary according to geometrical dimensions of emitting sections, such as diameter of the truncated cone, fiber core diameter and length of the fiber segment in front of the fiber with its truncated cone. In a preferred embodiment, the fiber and the short fiber segment are “butt-coupled” inside the glass dome with no additional adhering means. The fiber and the short fiber segment are laterally fused to the protective glass dome.

Abstract: The invention relates to a device for penetratingly extending a blind hole into a hard tissue, particularly a jawbone. The device is characterized in that it comprises a tubular body (1) having a distal working opening (2) and an inlet (3) opposite the working opening (2), said inlet being closed by a sealing element (4) that is penetrated by a shaft (5) of a working tool, for example a milling tool (5, 6), and allows at least a feed motion, a drive motion and a steering motion of the working tool (5, 6), the tubular body (1) being provided with a connection (8) for applying an internal pressure.

Abstract: Exemplary embodiments of the present disclosure provide method and apparatus for providing electromagnetic radiation to a biological tissue that may be selectively absorbed by venous structures as compared to arteries. For example, a wavelength of the electromagnetic radiation can be selected based on absorptivity of the radiation by oxygenated hemoglobin, deoxygenated hemoglobin, and/or met-hemoglobin. The wavelength can be, e.g., between about 685 nm and about 705 nm, or between about 690 nm and about 700 nm, or about 694 nm. The exemplary methods and apparatus can be used, e.g., for photothermolysis treatment of venous structures such as port wine stains or varicose veins, while reducing or avoiding undesirable damage to nearby arteries in the irradiated tissue.

Abstract: A device is provided for illuminating a tissue surface to be treated. The device includes a catheter, a light emitter to emit light from the distal end of the catheter, and a distal cap disposed over the distal end of the catheter. The device includes a handle connected to the proximal end of the catheter. The light emitter can include a light guide extending through an interior channel of the catheter, and an external source of light operatively connected to the light guide. The light emitter can include a light emitting diode in the handle, or the light emitter can include a light emitting diode in the distal end of the catheter.

Abstract: A method, means, and apparatus to prevent and treat infections and disorders using germicidal light to inactivate and/or kill the organisms or cells that cause infections and other disorders. The method of treatment comprises irradiating the area to be treated using electromagnetic radiation of a germicidal nature. The method utilizes a previously unrecognized ability of germicidal light to penetrate the skin, nails, and other membranes sufficiently to successfully treat and prevent disorders. The electromagnetic radiation damages the organisms and cells that cause disorders such as skin and nail infections and renders them substantially incapable of reproducing. Without the ability to replicate the organism cannot continue to infest the skin and nails. The damage inflicted can also be sufficient to kill the organism outright. An infection is thereby prevented (if organisms are present, but infection has not yet begun), and the infection is cured if the infection already exists.

Abstract: An apparatus and a method are presented for detecting the focal position of an optical system (10) with a radiation source (12), a focusing imaging system (16), an at least partially reflective surface (18) on the focus (18a), a digital camera (24) for recording an image reflected by said surface (18), a computer (C) for evaluating the image recorded by the camera (24), and with an optical element (34; 36) in the beam path of the optical system (10) upstream of the focusing imaging system (16), which element influences said image depending on the focal position.

Abstract: A device and related method for the removal of subcutaneous adipose layers comprises a laser source; an optical fiber for conveying a laser beam emitted by the laser source; and a hollow cannula for guiding the fiber to the subcutaneous treatment area. The cannula has a curved portion at its distal end, where the curved portion can be shaped to roughly conform to the contour of the patient's body structure. In this way, laser energy from the fiber, applied to the adipose layers, is generally directed away from the lower dermis of the patient, minimizing the risk of non-reversible damage to the dermis, including skin necrosis. In another embodiment, the optical fiber is a side-firing fiber that directs the laser energy away from the dermis. In other embodiments, a radiation detector, such as a thermal or optical sensor, monitors the temperature at the surface of the skin above the treatment area to warn the operator of harmful temperatures in the lower dermis.

Abstract: A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices. For treatment of male varicocele, insertion is preferably made directly at the testicle. Alternatively, insertion can be made in the femoral vein and advanced using a catheter. Preferably, x-ray, angiography, or other imaging techniques are used to visualize and position the catheter. An optical fiber is then inserted into the catheter and the distal end is advanced to a predetermined point near the varix or varices. Optical fiber distal end is preferably a slim, radial 360 degree emitting fiber end.

Abstract: A biostimulative illumination apparatus for treating patient tissues includes at least one light emitting diode which can generate at least one narrow-pulse focused wave band suitable to be used as low-power and non-parallel focused light beams for biostimulative illumination. The wave length of the focused light beam is from 600 nm to 850 nm, the energy density of the focused light beams is from 2 Joule/cm2 to 16 Joule/cm2 and the divergence angle of the light beams is lower than 16°. In addition, the invention also provides a biostimulative illumination treatment method.

Abstract: A fractional treatment system can be configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue increases as the tissue is heated by the laser (e.g., 1390-1425 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 8 cm?1 to about 30 cm?1. An adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. The system may be designed to be switchable between a treatment mode that is semi-ablative and a treatment mode that is not semi-ablative. Adjustment of these parameters can improve the efficiency and efficacy of treatment.

Abstract: Improved devices and methods for removing blood from a blood vessel in preparation for endovenous laser ablation are described. The improved methods include one or more of: placing the patient in the Trendelenburg position, applying external compression around the vein, massaging the vein, cooling the vein externally, encouraging spasming of the vein, and removing blood with a suction device.

Abstract: CdSiP2 crystals with sizes and optical quality suitable for use as nonlinear optical devices are disclosed, as well as NLO devices based thereupon. A method of growing the crystals by directional solidification from a stoichiometric melt is also disclosed. The disclosed NLO crystals have a higher nonlinear coefficient than prior art crystals that can be pumped by solid state lasers, and are particularly useful for frequency shifting 1.06 ?m, 1.55 ?m, and 2 ?m lasers to wavelengths between 2 ?m and 10 ?m. Due to the high thermal conductivity and low losses of the claimed CdSiP2 crystals, average output power can exceed 10 W without severe thermal lensing. A 6.45 ?m laser source for use as a medical laser scalpel is also disclosed, in which a CdSiP2 crystal is configured for non-critical phase matching, pumped by a 1064 nm Nd:YAG laser, and temperature-tuned to produce output at 6.45 ?m.

Abstract: A beam of radiation can be provided to treat a dermatological condition in a target region of skin. The beam of radiation can have a wavelength between about 700 nm and about 800 nm, a fluence greater than about 50 J/cm2, and a pulse duration between about 10 msec and about 300 msec. The beam of radiation is delivered to the target region of skin to affect (i) at least one pigmentary abnormality disposed in an epidermal region of the target region and (ii) at least one vascular abnormality disposed in a dermal region of the target region. A surface of the epidermal region of the target region of skin can be cooled to prevent substantial unwanted injury to at least a portion of the epidermal region.

Abstract: A dermatological treatment method includes directing laser energy having a wavelength of 2.79 ?m onto skin. According to disclosed methods, the energy can function to ablate a first portion of epidermal tissue, coagulate an underlying second portion of epidermal tissue, and promote collagen formation in tissue of the underlying dermis. In an exemplary treatment apparatus, a laser using a YSGG gain medium is mounted in a handpiece. The handpiece may include a two-axis scanner to allow for uniform scanning of the energy over the tissue surface.

Abstract: The invention is based on the object of specifying a laser scalpel, by means of which a high proportion of the laser light coupled into the scalpel body can be provided on the scalpel edge or is able to emerge therefrom. According to a first aspect, the invention is based on the idea of coupling the laser light into the scalpel body at an acute angle, with respect to the surface normal of the coupling-in surface, that is to say with respect to the direction or axis perpendicular or normal to the coupling-in surface.

Abstract: A dermatological treatment method includes directing laser energy having a wavelength of 2.79 ?m onto skin. According to disclosed methods, the energy can function to ablate a first portion of epidermal tissue, coagulate an underlying second portion of epidermal tissue, and promote collagen formation in tissue of the underlying dermis. In an exemplary treatment apparatus, a laser using a YSGG gain medium is mounted in a handpiece. The handpiece may include a two-axis scanner to allow for uniform scanning of the energy over the tissue surface.

Abstract: A method and apparatus, of providing endovascular therapy. The steps include arranging optical fibers within a catheter, the catheter having a tip whose length is at least 1 cm and whose diameter of less than 1 millimeter, connecting an excimer laser to the optical fibers; and delivering laser energy from the excimer laser in excess of a fluence of 60-mJ/mm2 at 40 Hertz through the optical fibers. The delivering of the laser energy may be to non-calcified or calcified deposits of an atherosclerotic lesion to ablate the same. The method also includes the step of inserting the catheter through an artery by pushing the same until the tip is in within laser energy striking distance of the atherosclerotic lesion.

Abstract: An ultrasound medical treatment system includes an end effector insertable into a patient. The end effector includes a tissue-retaining device. The tissue-retaining device includes a first tissue-retaining member having an ultrasound medical-treatment transducer and includes a second tissue-retaining member. The first and second tissue-retaining members are operatively connected together to retain patient tissue between the first and second tissue-retaining members and to release patient tissue so retained. In one example, the second tissue-retaining member has an ultrasound reflector. In the same or a different example, the ultrasound medical-treatment transducer is an ultrasound imaging and medical-treatment transducer.

Abstract: The invention is directed to a method, a laser system, and a kit for non-invasive treatment and removal of varices. In particular the invention allows for non-invasive laser treatment of large varices, such as varices having a diameter larger than 5 mm. The method of treatment can apply presently available dermatological lasers. The invention further propose developments and additions to presently available dermatological lasers making these particularly applicable to the treatment method.

Abstract: Deep Tissue Low Intensity Laser Therapy or Treatment (DT-LILT) as described here is a novel methodology through which selective destruction of nociceptive (pain) nerves can be brought upon by a medical laser delivery system using the phenomenon of absorption and cell resonance. Using this method nerve cells that transmit pain can be selectively destroyed leaving the surrounding tissues intact as no heat is generated. The delivery system incorporates a fine needle through which a 703 nm (range 690 to 710) pulsed wave low intensity laser is delivered deep into the body, directly to the area of pain causing selective destruction of pain nerves. Laser devices based on this methodology should be used only by the physician or equivalent professional community since diagnosing and defining the area of pain is critical to providing successful pain relief.

Abstract: The present invention relates to a field of systems for human skin medical treatments. The present system consists of a continuous wave-operated laser source (2) and of a biomedical laser system (1) connected to a scanning device (5) by means of an articulated transmission system (4) said laser being adapted to radiate a continuous CO2 laser beam.

Abstract: An ultrasound system and method to measure an organ wall weight and mass. When the organ is a bladder, a bladder weight (UEBW) is determined using three-dimensional ultrasound imaging that is acquired using a hand-held or machine controlled ultrasound transceiver. The infravesical region of the bladder is delineated on this 3D data set to enable the calculation of urine volume and the bladder surface area. The outer anterior wall of the bladder is delineated to enable the calculation of the bladder wall thickness (BWT). The UEBW is calculated as a product of the bladder surface area, the bladder wall thickness, and the bladder wall specific gravity.

Abstract: A method for performing intrastromal ophthalmic laser surgery requires Laser Induced Optical Breakdown (LIOB) of stromal tissue without compromising Bowman's capsule (membrane). In detail, the method creates cuts in the stroma along planes radiating from the visual axis of the eye. Importantly, these cuts are all distanced from the visual axis. The actual location and number of cuts in the surgery will depend on the degree of visual aberration being corrected. Further, the method may include the additional step of creating cylindrical cuts in the stroma. The radial cuts and cylindrical cuts may be intersecting or non-intersecting depending on the visual aberration being treated.

Abstract: A method for performing intrastromal ophthalmic laser surgery requires Laser Induced Optical Breakdown (LIOB) of stromal tissue without compromising Bowman's capsule (membrane). In detail, the method creates cuts in the stroma over all, or portions of, a plurality of concentric cylindrical surfaces (circular or oval). Importantly, these cuts are all centered on the visual axis of the patient's eye. In accordance with the present invention, cuts can be made either alone or in conjunction with the removal of predetermined volumes of stromal tissue. The actual location of cuts in the surgery will depend on whether the treatment is for presbyopia, myopia, hyperopia or astigmatism.

Abstract: A system and method for performing laser induced optical breakdown (LIOB) in corneal tissue of an eye requires calculating a pattern of focal spots. LIOB is then induced at a first focal spot, and is continued at a plurality of interim focal spots within a time period ?. Each focal spot has a diameter “d1” and generates a temporal cavitation bubble of diameter “d2”. It then collapses within time “?” to a substantially stationary diameter “d3”, with (d1?d3?d2). Importantly, each focal spot is located more than “d2” from every other interim focal spot within the time period of “?”. At the time “?”, a second focal spot in the pattern can be generated at a distance “d3” from the first focal spot. This process is then continued with another plurality of interim focal spots being generated within another time period “?”.

Abstract: The invention comprises a system and method for non-ablative laser treatment of dermatologic conditions. A laser energy is transmitted to an underlying target element in the skin. The target element is heated to a temperature of at least forty degrees Celsius. In some embodiments, a pulsed, near infrared, high peak power laser energy is used. The systems and methods of the present invention may be used to treat acne, smooth wrinkles, remove hair, treat leg veins, treat facial veins, improve skin texture, decrease pore sizes, reduce rosacea, reduce “blush/diffuse redness, reduce striae, reduce scarring, or the like.

Abstract: Output optical energy pulses including relatively high energy magnitudes at the beginning of each pulse are disclosed. As a result of the relatively high energy magnitudes which lead each pulse, the leading edge of each pulse includes a relatively large slope. This slope is preferably greater than or equal to 5. Additionally, the full-width half-max value of the output optical energy distributions are between 0.025 and 250 microseconds and, more preferably, are about 70 microseconds. A flashlamp is used to drive the laser system, and a current is used to drive the flashlamp. A flashlamp current generating circuit includes a solid core inductor which has an inductance of 50 microhenries and a capacitor which has a capacitance of 50 microfarads.

Abstract: A portable hair treatment device 1 includes a hand held portion or wand 2 containing a laser and associated optics for effecting skin treatment. The device includes a main base unit 3 including a recess shaped to receive the hand held unit 2 when not in use. At least one of the base unit 3 and the wand 2 includes a portable power source, e.g. a battery, to enable self-powered use.

Abstract: A medical tool for dental treatments by means of a laser, the light guide of which runs in a hand piece. The light guide is provided with a laser module including power circuitry and a second laser module is provided with the first laser module, operating at a different wavelength.

Abstract: A laser is used to both remove fat and alter the collagen in the skin under the eye. Precisely controlling the heat rise in the dermis is critical to not only the fat removal and alteration of the collagen but also to prevent damage to surrounding tissue. The denatured collagen results in tightening of the skin, further enhancing the benefits of the procedure. The fat is removed by melting or vaporizing the fat deposits, depending on the laser strength. The method is minimally invasive with a short recovery time.

Abstract: Disclosed is a surgical laser system. The system includes a laser generator to generate laser radiation to cause water absorption levels that approximate water absorption levels achieved with a CO2 laser, and one or more fibers coupled to the laser generator to deliver the generated laser radiation. In some embodiments, the laser generator is configured to generate radiation at multiple possible wavelengths in a range of between about 2.4 ?m to about 2.75 ?m.

Abstract: The invention relates to a device (1) for shortening hairs (3), in particular growing from human skin (5). The device (1) has a laser source (7) for generating a laser beam (9) during a predetermined pulse time, an optical system (15) for focusing the laser beam into a focal spot (25), and a laser beam manipulator (17) for positioning the focal spot in a target position. According to the invention, a dimension of the focal spot (25) and a power of the generated laser beam (9) are such that, in the focal spot (25), the laser beam has a power density which is above a characteristic threshold value for hair tissue above which, for the predetermined pulse time, a laser induced optical breakdown (LIOB) phenomenon occurs in the hair tissue. The LIOB phenomenon results in a number of mechanical effects in the hair tissue, such as cavitation and the generation of shock waves, which damage the hair (3) in positions surrounding the position in which the LIOB phenomenon occurs.

Abstract: Methods and apparatus for damaging hair follicles using a series of rapidly-delivered low-fluence pulses of coherent or incoherent light are disclosed herein. In some embodiments, the pulses of coherent or incoherent light have a wavelength or wavelengths primarily in the range between 750 nm and 1500 nm. In some embodiments, applied electromagnetic radiation comprising the rapidly-delivered low-fluence pulses is effective for concomitantly heating both the sub-dermal layer (i.e. the dermis) of the tissue and the hair follicles. In some embodiments, the thermal damaging of the hair follicles is useful for facilitating hair-removal.

Abstract: A laser hair removal device 10 has a base unit 12 and a hand held laser wand 14. Laser 18 generates light pulses of sufficient energy and duration to damage papilla of each hair follicle in the path of the beam. The device 10 includes one or more safety features to prevent accidental misuse of the device. In particular, the device incorporates a high intensity LED 24 which makes looking at the potential path of the laser uncomfortable, thus promoting a blinking reflex. Additionally the device may incorporate a skin contact/proximity sensor 26 to prevent use of the laser away from the skin, and/or one or more locking element to prevent accidental powering of the laser.

Abstract: Disclosed herein is a method of treating mammalian, for example, human, skin afflicted with a sebaceous follicle disorder, for example, acne. The method involves cooling an exposed surface of a region afflicted with the disorder and applying light, for example, light from a coherent or incoherent light source, to the region. The applied light reduces the size and/or density of lesions associated with the disorder in the treated region, and can reduce or otherwise alleviate lesion-associated skin inflammation in the treated region. Cooling preserves the surface, for example, epidermis, of the skin. The method, therefore, is effective at treating the disorder while at the same time avoiding or minimizing thermal damage to the exposed surface of the skin.

Abstract: An infrared energy photo-biotherapy medical treatment device incorporating a Class IV laser light source is disclosed. The medical treatment device comprises a head assembly, a coupling device and the Class IV laser light source. A liquid light guide connects the head assembly to the coupling device and the Class IV laser light source is connected to the coupling device by a plurality of silica optical fibers. Optical lenses are incorporated in both the head assembly and the coupling device permitting the infrared energy photo-biotherapy medical treatment device to direct the infrared energy from the Class IV laser light source through the optical fibers, coupling device, liquid light guide and head assembly so as to penetrate into a living organism.

Abstract: Methods and apparatus are provided for selectively heating blood vessels in a patients skin to effect a desired dermatological (medical or cosmetic) treatment. For shallow vessels, particularly plexus vessels and superficial vessels/veins, radiation is applied to the vessels involved in the treatment which includes substantial radiation in a blue band of approximately 380-450 nm. The invention also involves maximizing the radiation used for which the safety radio for the area being treated is greater then one and minimizing the radiation used for which the safety ratio is less then one. This generally involves, depending on the blood vessel involved in the treatment and the patient's skin type, using radiation in one or more of a blue, green-yellow and near infrared wavelength band and filtering out radiation at other wavelengths, including radiation between the wavelength bands used.

Abstract: A laser system for a spectroscopic catheter system uses multiple semiconductor gain media having gain peaks at different wavelengths. The output from the gain media is preferably coupled into single-mode fiber using conventional opto-electronic packaging techniques. As a result, the laser oscillator source has a spectral output that is wider than the gain bandwidth of a single medium to enable it to access the entire spectrum of interest, which is presently in the near infrared. Moreover, the semiconductor gain media can be packaged in a stable and controlled environment for long-term performance.

Abstract: This invention is an improved method and device for treating varicose veins 200 or the greater saphenous vein 202. The method comprises the use of infrared laser radiation in the region of 1.2 to 2.2 um in a manner from inside the vessel 200 or 202 such that the endothelial cells of the vessel wall 704 are damaged and collagen fibers in the vessel wall 704 are heated to the point where they permanently contract, the vessel 200 or 202 is occluded and ultimately resorbed. The device includes a laser 102 delivered via a fiber optic catheter 300 that may have frosted or diffusing fiber tips 308, or that may be provided with a protective spacer. A motorized pull back device 104 may be used, and a thermal sensor 600 may be used to help control the power required to maintain the proper treatment temperature.

Abstract: A Nd:YAG laser at a wavelength of 1444 nm for removing fatty tissue is disclosed, which can directly irradiate laser light onto subcutaneous fat and efficiently remove fatty tissue with an adverse reaction on surrounding tissue minimized by using laser light at an oscillating wavelength of 1444 nm which has both a high fat absorptivity and a high water absorptivity among wavelengths that can be oscillated by the Nd:YAG laser. The Nd:YAG laser includes a flash lamp, a Nd:YAG rod, a high reflection mirror, an output coupler, a convergent lens for converging the laser light beam oscillating through the output coupler, an optical fiber for guiding the converged laser beam, and a guide needle for guiding the laser beam from the guide fiber to subcutaneous fat. Both end surfaces of the Nd:YAG rod, an inner surface of the high reflection mirror, and inner and outer surfaces of the output coupler are coated so as to oscillate only the laser beam at the wavelength of 1444 nm through the output coupler.

Abstract: Disclosed is a system and method for treating and preventing skin disorders. More particularly, the disclosed invention is directed toward the prevention of acne and acne scarring by treating sebaceous oil glands and the surrounding tissue with an exogenous chromophore composition and then exposing the target tissue to visible, infrared, or ultraviolet light to inhibit the activity of the oil gland and eliminate acne bacteria. The method of the present invention may be further augmented by enhancing the penetration of the topical composition into the oil gland and surrounding tissue through the use of procedures including enzyme peeling, microderm abrasion, or ultrasound.

Abstract: The method of prevention and treatment of microbial infections that occur on, or just below, the skin and nails of a person consisting of applying a means to inactivate the microbes thus rendering them harmless. The treatment consists of applying a means which alters the skin or nail so that the skin or nail will either no longer serve as a food source, will be inhibitory to the organism, will be toxic to the organism, or will be altered in a manner that makes it more responsive to treatment of infections.

Abstract: Provided are a process for producing an intraocular lens capable of inhibiting secondary cataract that may occur after the insertion of an intraocular lens and a secondary-cataract-inhibiting intraocular lens obtained by the above process, and the process is for producing a surface-treated intraocular lens, which comprises irradiating the surface of an intraocular lens with active light that works to decompose oxygen molecules to generate ozone and that also works to decompose the ozone to generate active oxygen, in the presence of oxygen, and the lens is a secondary-cataract-inhibiting intraocular lens obtained by the above process.

Abstract: Penile illuminating equipment includes a plurality of light emitting diodes positioned on a mounting structure in a manner to illuminate a penis with light emitted from the diodes along the penis' length and circumference. Optionally, a penis enlargement device may be used in combination with the penile illuminating equipment.

Abstract: An ophthalmic phototherapy device (10) and associated phototherapy treatment method for promoting healing of damaged or diseased eye tissue. The ophthalmic phototherapy device (10) includes a light emitting mechanism (12) for transmitting light of at least one preselected wavelength to the eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates activity in the eye tissue to promote healing. The ophthalmic phototherapy method includes exposing the damaged or diseased eye tissue to light of at least one wavelength for a selected period of time.

Abstract: An additive, preferably in the form of metal nanoparticles or nanodomains, greatly improves a laser-based method and system for inducing optical breakdown. The use of ultrashort laser pulses to induce laser-induced breakdown (LIB) in metal nanoparticles or nanocomposites makes it possible to reduce significantly the threshold laser energy required for LIB. Such nanoscale (submicron) metallic particles allows one to control the LIB process. The nanoparticles can be synthesized so as to target specific biological structures or tissues (dendrimer nanoparticles are one system for which this has been demonstrated). This opens up the possibility of performing LIB for targeted cancer treatment or microsurgery.

Abstract: An optical screening device for detecting abnormal skin tissue indicative of disease including a handle having an elongated stem adapted for holding the optical screening device in one hand and a head for housing an array of light emitting diodes with each diode in the array being spaced apart to form a given geometry with each diode selected to emit light in a wavelength range between 340 nm to 470 nm; a high pass filter supported by said handle in close proximity to said array of light emitting diodes with the filter being of a size to provide a defined viewable area for visibly detecting irradiated light reflected from skin tissue under observation and adapted to block light at least below 400 nm; and a source of electrical power for energizing said array of light emitting diodes.

Abstract: Methods of treatment of tissue with electromagnetic radiation (“EMR”) to produce lattices of photoselective islets and other energy selective islets in tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

Abstract: A laser treatment device and process with controlled cooling. The device contains a cooling element with high heat conduction properties, which is transparent to the laser beam. A surface of the cooling element is held in contact with the tissue being treated while at least one other surface of the cooling element is cooled by the evaporation of a cryogenic fluid. The cooling is coordinated with the application of the laser beam so as to control the temperatures of all affected layers of tissues. In a preferred embodiment useful for removal of wrinkles and spider veins, the cooling element is a sapphire plate. A cryogenic spray cools the top surface of the plate and the bottom surface of the plate is in contact with the skin. In preferred embodiments the wavelength of the laser beam is chosen so that absorption in targeted tissue is low enough so that substantial absorption occurs throughout the targeted tissue. In a preferred embodiment for treating large spider veins with diameters in the range of 1.