Abstract: CdSiP2 crystals with sizes and optical quality suitable for use as nonlinear optical devices are disclosed, as well as NLO devices based thereupon. A method of growing the crystals by directional solidification from a stoichiometric melt is also disclosed. The disclosed NLO crystals have a higher nonlinear coefficient than prior art crystals that can be pumped by solid state lasers, and are particularly useful for frequency shifting 1.06 ?m, 1.55 ?m, and 2 ?m lasers to wavelengths between 2 ?m and 10 ?m. Due to the high thermal conductivity and low losses of the claimed CdSiP2 crystals, average output power can exceed 10 W without severe thermal lensing. A 6.45 ?m laser source for use as a medical laser scalpel is also disclosed, in which a CdSiP2 crystal is configured for non-critical phase matching, pumped by a 1064 nm Nd:YAG laser, and temperature-tuned to produce output at 6.45 ?m.

Abstract: A device and method to improve the ultrasound visibility of a catheter placed inside the body is described. The catheter is sonically vibrated by an external driver device that transmits the acoustic vibration down the catheter and inside the body. An ultrasound transducer is used to pick up the ultrasound vibrations directly or detects the sonic vibrations using a Doppler mode ultrasound machine.

Abstract: A system includes at least one radiation source configured to generate radiation for a cornea reshaping procedure and a corneal cross-linking procedure. The system also includes a delivery device configured to deliver the radiation to the patient's eye. The system further includes a controller configured to control the delivery of the radiation to the patient's eye during the cornea reshaping procedure and the corneal cross-linking procedure. The controller may be configured to control the delivery of radiation so that the cornea reshaping procedure and the corneal cross-linking procedure at least partially overlap in time. The delivery device may be configured to deliver radiation to specified areas of the patient's eye during the cornea reshaping procedure and to deliver radiation only to the same specified areas of the patient's eye during the corneal cross-linking procedure.

Abstract: Inducing thrombolysis of thermally induced thrombus occurring during endovenous ablation of varicose veins by introducing an optical fiber laser deliver device with optical fiber portion and with an energy emitting tip at its distal end into the varicosed vein to be treated, emitting pulsed, laser energy with sufficient energy to close and destroy varicose veins to the emitting tip of the optical fiber laser delivery device, thereby inducing laser thrombolysis of coagulated blood which accumulates at the energy emitting tip of the fiber when the fiber is caused to emit energy in the presence of uncoagulated blood and minimizing adverse effects associated with thermally induced thrombus within a varicose vein.

Abstract: Non-ablative skin resurfacing can include generating electromagnetic radiation having a wavelength of about 1920 nm to about 1950 nm and a fluence of about 3 J/cm2 to about 6 J/cm2. The electromagnetic radiation is delivered to a target region of skin to cause thermal injury to the epidermis in the target region sufficient to elicit a healing response that produces a substantially improved skin condition without detachment of the epidermis (e.g., within 3 days of treatment).

Abstract: A wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated wavefront measurements of a patient's eye while the patient remains on an operating table in the surgical position. The device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap. The inclusion of lightweight, compact diffractive optical components in the wavefront sensor allows the integrated device to be supported on a balancing mechanism above a patient's head during a surgical procedure. As a result, the need to reposition the device and/or the patient between measuring optical properties of the eye and performing surgical procedures on the eye is eliminated. Many surgical procedures may be improved or enhanced using the integrated device, including but not limited to cataract surgery, Conductive Keratoplasty, Lasik surgery, and corneal corrective surgery.

Abstract: Disclosed herein is a novel method of treating vitiligo by using an excimer laser that emits light in the UVB range. The invention includes a method of incrementally increasing exposure of affected vitiligo areas with UVB laser light from an excimer laser to restore pigmentation to skin areas afflicted with vitiligo.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: A cardiac ablation instrument capable of removing blood from a treatment area is provided. The instrument includes a catheter configured to deliver a distal end thereof to a patient's heart. The instrument can also include an expandable element coupled to the distal end of the catheter wherein the expandable member is configured to be positioned adjacent a target area thereby defining a treatment area between the expandable member and the target area. Further, the instrument can include an irrigation mechanism configured to dispense an irrigation fluid from the catheter thereby displacing blood from the treatment area. Additionally, the instrument includes an energy emitter configured to deliver energy to tissue within the treatment area. The instrument can also include a contact sensor configured to determine the presence of such blood within the treatment area. Methods for ablating tissue are also provided.

Abstract: Portable laser hair removal of multi purpose use comprising a housing (2) with a head (11) and transparent dome (3) with bottom hole (4) having a laser illumination system with two diodes (5, 6), different in wavelength, power, opening, pulse period and average power pulse size in red and infrared, respectively.

Abstract: A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal.

Abstract: A method and apparatus are provided for processing a hard material, for example a hard biological material such as dental enamel or bone, with optical radiation. A treatment zone of the material is selectively cleaned of ablation products and other dirt to enhance processing efficiency, and a tip through which the optical radiation is applied to the treatment zone of the hard material is spaced slightly from the treatment zone during at least a portion of the time that hydrating fluid is being applied to the zone and/or while air or another gas is applied to the zone to clean the surface thereof.

Abstract: An arrangement for carrying out surgical laser treatments of the eye is adapted to emit pulsed treatment radiation with a wavelength of between about 190 nm and about 380 nm and a pulse duration in the femtosecond range. Such treatment radiation allows nonaggressive corneal or intraocular laser treatment of the eye, for example in order to make corneal cuts or deliberately ablate corneal tissue.

Abstract: A laser device is described for skin ablation treatment. The device comprises a laser source (5) and a handpiece (9). The laser beam has a Gaussian distribution of the power density to obtain different effects in the various regions exposed to the laser beam.

Abstract: A dermatological treatment method includes directing laser energy having a wavelength of 2.79 ?m onto skin. According to disclosed methods, the energy can function to ablate a first portion of epidermal tissue, coagulate an underlying second portion of epidermal tissue, and promote collagen formation in tissue of the underlying dermis. In an exemplary treatment apparatus, a laser using a YSGG gain medium is mounted in a handpiece. The handpiece may include a two-axis scanner to allow for uniform scanning of the energy over the tissue surface.

Abstract: In a fractional treatment system, an adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements. In one aspect, the fractional treatment is configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue decreases as the tissue is heated by the laser (e.g., 1480-1640 nm).

Abstract: A device and method for safe, substantially blood-free vessel removal that preserves vein patency are disclosed. A specially designed lens-free laser vessel stripping device is inserted into the body and coupled to a laser energy source, to remove a major vessel while cutting and coagulating its lateral branches with minimal damage to surrounding tissue. Energy source is preferably a diode laser source emitting at wavelengths of about 980 nm, about 1470 nm or a combination of these wavelengths for obtaining best ablative and coagulative effects, thus achieving a safe and efficient removal of vessels with minimum collateral damage and thus faster recovery. Veins harvested using this device and method are better candidates for autologous grafts in other surgeries.

Abstract: The present invention generally relates to methods for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, methods of the invention involve inserting into an eye a deployment device configured to hold an intraocular shunt, determining that a distal portion of the device is properly positioned within the eye without use of an optical apparatus that contacts the eye, and deploying the shunt from the device.

Abstract: A spectroscopic diagnostic apparatus is disclosed as an aid for laser tattoo removal. The apparatus performs spectroscopic analysis of the tattooed skin before or during laser treatment, which provides composition information of the tattoo pigments and photometric information of the skin for optimizing laser treatment protocols automatically or manually. It also provides a simulated treatment result for the selected laser types.

Abstract: Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization.

Abstract: Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be effected under gonioscopic control. Internal delivery may he controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

Abstract: Inducing thrombolysis of thermally induced thrombus occurring during endovenous ablation of varicose veins by introducing an optical fiber laser deliver device with optical fiber portion and with an energy emitting tip at its distal end into the varicosed vein to be treated, emitting pulsed, laser energy with sufficient energy to close and destroy varicose veins to the emitting tip of the optical fiber laser delivery device, thereby inducing laser thrombolysis of coagulated blood which accumulates at the energy emitting tip of the fiber when the fiber is caused to emit energy in the presence of uncoagulated blood and minimizing adverse effects associated with thermally induced thrombus within a varicose vein.

Abstract: A fractional treatment system can be configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue increases as the tissue is heated by the laser (e.g., 1390-1425 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 8 cm?1 to about 30 cm?1. An adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. The system may be designed to be switchable between a treatment mode that is semi-ablative and a treatment mode that is not semi-ablative. Adjustment of these parameters can improve the efficiency and efficacy of treatment.

Abstract: A dermatological treatment device includes a device body; a laser diode bar configured to generate laser radiation for delivery to a target area of tissue, the laser diode bar having a fill factor of at least 50%; a power source; and control electronics configured to provide power from the power source to the laser diode bar such that the laser diode bar generates a laser beam; wherein the device is configured for delivering the generated laser beam to the target area of tissue to provide a dermatological treatment.

Abstract: A dermatological treatment method includes directing laser energy having a wavelength of 2.79 ?m onto skin. According to disclosed methods, the energy can function to ablate a first portion of epidermal tissue, coagulate an underlying second portion of epidermal tissue, and promote collagen formation in tissue of the underlying dermis. In an exemplary treatment apparatus, a laser using a YSGG gain medium is mounted in a handpiece. The handpiece may include a two-axis scanner to allow for uniform scanning of the energy over the tissue surface.

Abstract: Disclosed is a computer-implemented method for correcting refractive errors in a living eye using a laser vision correction system that involves first calculating an amount of sphere based on preoperative manifest refraction and higher order aberrations data associated with the eye, and then correcting for the calculated amount of sphere by ablating at least a portion of the eye. The preoperative manifest refraction may include preoperative manifest sphere, preoperative spherical equivalent, regular astigmatism, and oblique astigmatism, and the preoperative higher-order aberrations may include 4th-order spherical and 3rd root mean square. Other factors may also be used to adjust the calculated amount of sphere. A device readable medium for storing the calculation and instructions for operating a laser vision correction system for practicing the method is also disclosed, as is a method of treating refractive errors.

Abstract: A broadband light source includes one or more laser diodes that are capable of generating a pump signal having a wavelength shorter than 2.5 microns, a pulse width of at least 100 picoseconds and a pump optical spectral width. The light source also includes one or more optical amplifiers that are coupled to the pump signal and are capable of amplifying the pump signal to a peak power of at least 500 W. The light source further includes a first fiber that is coupled to the one or more optical amplifiers. The first fiber including an anomalous group-velocity dispersion regime and a modulational instability mechanism that operates to modulate the pump signal. The light source also includes a nonlinear element that is coupled to the first fiber that is capable of broadening the pump optical spectral width to at least 100 nm through a nonlinear effect in the nonlinear element.

Abstract: A multi-wavelength laser apparatus and methods for laser ablation of tissue are described. The apparatus and methods utilize a laser source emitting at two or more wavelengths coupled to a fiberoptic laser delivery device and a laser driver and control system with features for protection of the laser delivery device, the patient, the operator and other components of the laser treatment system. A fiber tip protection system limits damage to the fiberoptic laser delivery device, thereby allowing the multi-wavelength laser to be operated in a tissue contact mode. The invention, which has broad medical and industrial applications, is described in relation to a method for treatment of benign prostatic hyperplasia (BPH) by contact laser ablation of the prostate (C-LAP) using a technique of touch and pullback laser ablation of the prostate (TapLAP).

Abstract: Device/system and treatment method of varicose veins and other vein abnormalities are presented. Treatment A comprises combining two wavelengths to occlude abnormal veins. Wavelengths are chosen as effective absorption peaks of hemoglobin and/or water, e.g. 980 nm and 1460 nm. Irradiations of blood, collagen and water in the vessel cause occlusion/shrinkage. Constant power-density is used based on fiber withdrawal speed and structural vein parameters. Treatments employ dual laser wavelengths or highly-controlled vein-wall damage wavelengths. Monitored control parameters and predetermined vein structural parameters. Alternatively, 1460+60 nm laser energy is employed, having high absorption in the vein wall, creating little thermal stress outside the vein, and being effective in initiating damage reaction response. Treating at 1460+60 nm has benefits of high vein closure rates and favorable post-operative results, i.e.

Abstract: The invention relates to an aqueous composition used in the laser repair treatment of fibrous connective tissue, including: gold nanoparticles in a concentration of between 1.5×109 particles per ml and 1×1010 particles per ml; and albumin and/or collagen in a concentration of between 30 wt % and 45 wt %. The invention also relates to an assembly including such a composition.

Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

Abstract: Disclosed herein is a fat removal 1414 nm Nd:YAG laser apparatus for direct irradiation into fat. The apparatus includes a flashlamp which is supplied the electrical power from the power supply unit and emitting light; an Nd:YAG rod radiate a laser wavelength and amplify a laser wavelength after absorbed the pumping light from flashlamp; a high reflector and an output coupler located on two sides of the Nd:YAG rod and configured to reflect laser wavelength radiated from the Nd:YAG rod; a convergence lens for converging a laser beam; an optical fiber for delivery the laser beam; and a cannula coupled to the output end of the optical fiber and configured to allow the optical fiber to extend underneath skin without being bent, thereby delivery the laser beam to hypodermic fat. Both end surfaces of the Nd:YAG rod, the internal surface of the high reflector, and the internal and external surfaces of the output coupler are coated in order to obtain only the laser beam with the wavelength of 1414 nm wavelength.

Abstract: Techniques for altering iris pigment in a human or animal, thereby altering iris color of an iris from a first iris color to a second iris color, are provided. An apparatus includes at least one laser device and a masking device. Another apparatus includes at least one laser device and a contact lens. The at least one laser device can generate at least one beam to selectively remove iris pigment of at least one preselected pigment color from the iris. The energy level of the at least one beam is within a predetermined range. The masking devices include a transparent portion and an opaque portion. The opaque portion of one such masking device occludes a portion of the at least one beam to protect a pupil area. The opaque portion of another such masking device creates an elliptical beam for application of the beam laterally from the side of the iris or some other different angle for lateral exposure of the iris. The contact lens includes a transparent portion and an opaque portion.

Abstract: The present invention provides systems, devices, and methods to vaporize prostatic tissue having oxygenated hemoglobin. The systems, devices, and methods include a laser module configured to emit light near an absorption peak of the oxygenated hemoglobin and a delivery catheter that is optically coupled to the laser module and configured to deliver the light from the laser module to the prostatic tissue.

Abstract: A pulsed radiation beam is directed toward a body structure having a configuration or physical characteristic that changes over time, the radiation being pulsed at a pulse modulation frequency. A detector detects acoustic oscillations set up in the body resultant from the incident pulsed radiation and produces an output signal representative of one or more parameters of the acoustic oscillations. A control system controls operation of the radiation delivery and a processor to process the detector output signal. The pulse modulation frequency of the pulsed radiation is changed over a predetermined range of modulation frequencies and the processor determines the structure resonant frequency from the detector output.

Abstract: A photodynamic therapy (PDT) method to treat primary sites of hyperproliferative tissue and induce long term, tumor specific immunity for regression and eradication of distant metastases is disclosed. The improved treatment regimen comprises the partial or fractional application of PDT with several applications, spaced in time, to permit a patient's immune system to react to dead tissue generated by each fractional application. Once activated, the immune system can help reduce or eliminate secondary stage tumors and metastasis stage tumors.

Abstract: A method for precise working of material, particularly organic tissue, comprises the step of providing laser pulses with a pulse length between 50 fs and 1 ps and with a pulse frequency from 50 kHz to 1 MHz and with a wavelength between 600 and 2000 nm for acting on the material to be worked. Apparatus, in accordance with the invention, for precise working of material, particularly organic tissue comprising a pulsed laser, wherein the laser has a pulse length between 50 fs and 1 ps and with a pulse frequency of from 50 kHz to 1 MHz is also described.

Abstract: Apparatus for photothermolysis including a removable and disposable cartridge mounted in a hand-held housing, the cartridge including a light source connectable to a power supply external to the cartridge, a reflector arranged with respect to the light source to direct light emanating from the light source towards skin via an opening formed in the cartridge to cause removal of hair on the skin by photothermolysis, and a spectral filter for filtering the light before the light exits the opening.

Abstract: Sinusitis, enlarged nasal turbinates, tumors, infections, hearing disorders, allergic conditions, facial fractures and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies, endoscopic studies and transillumination studies. Access and occluder devices may be used to establish fluid tight seals in the anterior or posterior nasal cavities/nasopharynx and to facilitate insertion of working devices (e.g., scopes, guidewires, catheters, tissue cutting or remodeling devices, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting devices, substance delivery implants, etc.

Abstract: A method of laser processing of materials and specifically laser induced ablation processes for laser removal of material by impulsive heat deposition (IHD) by direct and specific excitation of short lived vibrations or phonons of the material in such a way as to not generate highly reactive and damaging ions through multiphoton absorption. The heat deposition and ensuing ablation is achieved faster than heat transfer to surrounding tissue by either acoustic or thermal expansion or thermal diffusion. The deposited laser energy is channeled into the ablation process to drive the most efficient ablation process possible with minimal damage to surrounding areas by either ionizing radiation or heat effects.

Abstract: A method and system for skin tightening comprises a hollow cannula that contains an optical fiber connected to a laser source. The cannula is inserted subcutaneously into a patient so that the end of the fiber is located within the tissue underlying the dermis. The source emits an output pulse that is conveyed by the fiber to the dermis, where the pulse causes collagen destruction and shrinkage within the treatment area. Radiation from the skin surface is detected to prevent non-reversible damage to the dermis, such as skin necrosis and excessive collagen melting. This method of sub-cutaneous laser treatment can also be used to treat striae, or stretch marks.

Abstract: An optical therapy device for providing therapeutic light to a person's nasal cavity includes a body and at least one UV light source in or on the body. A distal end of the body is configured to be inserted into the person's nasal cavity. The body can be configured to be hand-held. The optical therapy device is configured such that the UV light source emits a dose of UV light toward tissue in the patient's nasal cavity.

Abstract: A laser surgical method is disclosed including: providing a laser surgical device including a handpiece including: an optical delivery component that transmits laser energy from a source to a treatment volume; and an accelerometer configured to provide information indicative of the position of the handpiece. The method includes using the handpiece to transmit laser energy from the source to a plurality of positions within the treatment volume; using the accelerometer, providing information indicative of the position of the handpiece; determining information indicative of an amount of energy delivered at each of the plurality of positions within the treatment volume based on the information indicative of the position of the handpiece, and displaying a graphical representation indicative of the amount of energy delivered at each of the plurality of positions within the treatment volume.

Abstract: In a device for material processing by laser radiation, including a source of laser radiation emitting pulsed laser radiation for interaction with the material; optics focusing the pulsed processing laser radiation to a center of interaction in the material and a scanning unit shifting the positions of the center of interaction within the material. Each processing laser pulse interacts with the material in a zone surrounding the center of interaction assigned to the laser pulse so that material is separated in the zones of interaction. A control unit controls the scanning unit and the source of laser radiation such that a cut surface is produced in the material by sequential arrangement of zones of interaction. The control unit controls the source of laser radiation and the scanning unit such that adjacent centers of interaction are located at a spatial distance a?10 ?m from each other.

Abstract: Optical ear infection treatment device and methods are described where an LED and optical light pipe are used to deliver the light from the LED to the middle ear of a patient to reduce bacterial growth and/or eliminate bacteria. Typically, the device is placed in the ear and then activated by the user by pressing an activation button. Once activated the control electronics will turn on the LED and perform a treatment. The most basic treatment mode comprises turning on the LED at maximum power for a predetermined period, e.g. 30 minutes, 60 minutes. When the preset duration is completed, the device will notify the user by an audible beep or vibration that the treatment is complete. Once completed the user can remove the device, the treatment could be repeated once a day or for extreme cases multiple times during the day.

Abstract: An apparatus for laser processing of a material, in particular the eye cornea, emits on to the material a train (18?) of laser radiation pulses having a pulse duration in the femtosecond range. The pulse train comprises a multiplicity of successive pulse groups, each pulse group comprising at least two laser radiation pulses (20?, 22?). The pulses of a pulse group are directed at substantially the same processing site of the material, but the pulses of successive groups are directed at substantially different processing sites of the material. According to the invention the time interval between successive laser radiation pulses of a pulse group is in the nanosecond range. In particular, the intensity or energy of the pulses within a pulse group is graduated, in such a way that a preceding prepulse (20?) has substantially lower intensity or energy than a following main pulse (22?).

Abstract: A laser skin treatment process and system. The system includes features for producing a first laser beam of long pulse duration and a second laser beam of short pulse duration and a skin cooler for cooling the surface of a region of skin. The system is designed to utilize the first laser beam for heating a volume of skin tissue below the cooled surface region to a temperature to produce skin tissue modification but below skin tissue damage threshold. This volume of skin tissue is called a “thermal cavity”. The second laser beam is divided into a plurality of separate laser beams that are directed through separate optical fibers and via separate paths through skin tissue to a single tiny volume of skin tissue within the thermal cavity to produce in that tiny volume mechanical damage. This tiny volume is called an energy droplet. Thus tiny regions of tissue are damaged while minimizing or preventing any significant damage to adjacent tissue.

Abstract: A light therapy device for rhinitis treatment. The light therapy device includes a hollow tube body with a longitudinal axis, being dimensioned and configured to permit insertion into a nostril of a treatment subject. A light emitting diode package disposed within the hollow tube body includes a first LED chip as a red light source and a second LED chip as an infrared light source. The first LED chip and the second LED chip are at different plane substantially orthogonal to the longitudinal axis.

Abstract: A method and apparatus for ablating material. The material is preferably a heterogenous or composite material, such as animal tissue. A table top laser system can be employed in the invention. Alternatively, a larger laser, such as a free electron laser can be employed.

Abstract: A laser treatment device and process with controlled cooling. The device contains a cooling element with high heat conduction properties, which is transparent to the laser beam. A surface of the cooling element is held in contact with the tissue being treated while at least one other surface of the cooling element is cooled by the evaporation of a cryogenic fluid. The cooling is coordinated with the application of the laser beam so as to control the temperatures of all affected layers of tissues. In a preferred embodiment useful for removal of wrinkles and spider veins, the cooling element is a sapphire plate. A cryogenic spray cools the top surface of the plate and the bottom surface of the plate is in contact with the skin. In preferred embodiments the wavelength of the laser beam is chosen so that absorption in targeted tissue is low enough so that substantial absorption occurs throughout the targeted tissue. In a preferred embodiment for treating large spider veins with diameters in the range of 1.