Abstract: Systems and methods are provided for generating dynamic representations of symptoms and symptom alleviation.

Abstract: An external data retrieval apparatus receives a low resolution version of a physiological signal from an active implantable medical device and determines if the physiological signal represents a clinically significant event. The apparatus provides an indication of such determination to the implantable medical device. If the physiological signal does represent a clinically significant event, the apparatus receives a full download of the physiological signal from the implantable device.

Abstract: An active skull replacement system including an implant having an area A, an upper surface, and a bottom surface, adapted to be implanted at least in part into a skull of a subject so to substitute a portion of the skull, the bottom surface arranged to face at least in part a cranial cavity, and having a first wireless bidirectional data communication device, a device operably connected to the bottom surface of the implant, the device adapted to at least one of stimulate a physiological response and record a physiological parameter of the subject, and an external reader adapted to be placed on the scalp of the subject and including a second wireless bidirectional data communication device configured to communicate with the first wireless bidirectional data communication device of the implant to operate the device, wherein the external reader and the implant are fixed and aligned among each other through a magnetic device.

Abstract: A neurostimulation system comprises at least one neurostimulation lead configured for being implanted within tissue. The neurostimulation lead(s) carries a plurality of electrodes capable of being arranged in a two-dimensional pattern. The neurostimulation system further comprises a neurostimulator configured for delivering electrical stimulation energy to the electrodes to create a volume of activation, and an external control device including a current steering direction control element capable of being rotated about an axis. The external control device is configured for prompting the neurostimulator to deliver the electrical stimulation energy to the electrodes in a manner that gradually translates the volume of activation in a specific direction, and for defining the specific direction in which the volume of activation is translated in response to rotation of the direction control element about the axis.

Abstract: Embodiments are directed to a computer implemented neural stimulation system having a first module configured to derive neural data from muscle contractions or movements of a subject. The system further includes a second module configured to derive a neural state assessment of the subject based at least in part on the neural data. The system further includes a third module configured to derive at least one neural stimulation parameter based at least in part on the neural state assessment. The system further includes a fourth module configured to deliver neural stimulations to the subject based at least in part on the at least one neural stimulation parameter.

Abstract: A skull-mountable medical device is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient. A light pipe is attached to the housing. The device is configured to be positioned on a patient's skull with the light pipe extending into the patient's brain, such that light from the light source can irradiate a target position within the patient's brain. Once so positioned, the housing may be affixed to the skull via bone screws. The device is powered and controlled by an implantable pulse generator (IPG) that may be implanted into a patient's tissue remotely from the device and connected to the device by wire leads.

Abstract: Embodiments are directed to a computer implemented neural stimulation system having a first module configured to derive neural data from muscle contractions or movements of a subject. The system further includes a second module configured to derive a neural state assessment of the subject based at least in part on the neural data. The system further includes a third module configured to derive at least one neural stimulation parameter based at least in part on the neural state assessment. The system further includes a fourth module configured to deliver neural stimulations to the subject based at least in part on the at least one neural stimulation parameter.

Abstract: Disclosed are an apparatus and method for imaging electrical properties of brain tissues including conductivity and permittivity using magnetic resonance imaging (MRI) signals. Electrical properties images for conductivity and permittivity of brain tissues may be obtained with high spatial resolution and high accuracy, without using a derivative which significantly amplifies noise in an MRI image, by calculating water content based on a ratio of MRI signals, calculating electrical properties from the calculated water content, and acquiring an electrical properties image for the calculated electrical properties.

Abstract: Systems and methods are disclosed for blink detection, tracking, and stimulation. In one implementation, a device can include a sensor configured to receive an input, the input corresponding to perceiving one or more blinks of an eye of a user. The input can be processed to determine a blink rate or an elapsed time interval since a blink of the user. Based on the blink rate or the elapsed time interval, a blink stimulation action directed to the user can be initiated.

Abstract: A method of controlling a device relative to one or more objects in an environment of a user employing the device may include receiving a volitional input from the user indicative of a task to be performed relative to an object with the device, receiving object targeting information associated with interaction between the device and the object where the object targeting information is presented in an augmented reality context, integrating the volitional input with the object targeting information to determine a control command to direct the device to interact with the object, and providing the control command to the device.

Abstract: An external control device for use with a neurostimulator coupled to a plurality of electrodes capable of conveying electrical stimulation energy into tissue in which the electrodes are implanted. The external control device comprises a user interface including at least one control element, a processor configured for independently assigning stimulation amplitude values to a first set of the electrodes, for linking the first set of electrodes together in response to the actuation of the at least one control element, and for preventing the stimulation amplitude values of the first linked set of electrodes from being varied relative to each other, and output circuitry configured for transmitting the stimulation amplitude values to the neurostimulator.

Abstract: When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by obtaining electrical conductivity measurements in an anatomic volume and generating a 3D map of the conductivity directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types. A location of the target tissue is identified within the anatomic volume, and the positions for the electrodes are determined based on the 3D map of electrical conductivity and the position of the target tissue.

Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

Abstract: Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and/or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.

Abstract: A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape.

Abstract: Example apparatus and methods plan and control neuro-modulation of a distributed multi-region network in a brain. A location for a deep brain stimulation (DBS) electrode that participates in activating a combination of white matter pathways associated with the network is selected. The location is selected based on a pre-implantation image of the brain and a probabilistic activation model of the network. An initial stimulation parameter for DBS to be applied through the DBS electrode is selected based on a post-implantation image of the brain and the probabilistic activation model of the network. A modified stimulation parameter for DBS being applied through the DBS electrode is selected based on the initial stimulation parameter, a local field potential measured in the distributed multi-region network in response to DBS applied using the initial stimulation parameter, the probabilistic activation model of the distributed multi-region network, and the post-implantation image of the brain.

Abstract: Techniques and methods for evaluating an instance of a pre-defined task being performed by a user with a handheld tool. In an embodiment, measurement information is stored to a log based on sensor data generated during motion of the handheld tool. Based on a definition of a task and the logged measurement information, a determination is made as to whether the sensed motion corresponds to a performance of at least some action of the defined task. In another embodiment, the definition of the task includes or otherwise corresponds to criteria information. The performance of the task is evaluated based on the criteria information to detect bradykinesia or some other unintentional muscle performance of the user.

Abstract: In embodiments of the present disclosure, methods of treating a neurological disorder comprise providing reconditioning electrical stimulation. The methods may comprise applying electrical stimulation that provides positive reinforcement by activation within the reward network of the brain of the patient when an appropriate external stimulus is provided to the patient. The external stimulus is selected in accordance with the specific neurological disorder being treated in the patient. The methods may comprise applying electrical stimulation that provides negative reinforcement by stimulation of aversion-related locations of the brain of the patient when a different external stimulus is provided to the patient.

Abstract: A method for implanting a wireless neural stimulator device, the method including: making a surgical incision or a percutaneous opening on a patient's skin; inserting an assembly of an introducer or needle and a needle stylet through the surgical incision or a percutaneous opening and underneath the patient's skin, the needle stylet mounted in an inner lumen of the introducer or needle; withdrawing the needle stylet from the inner lumen of the introducer or needle when the assembly is in place; inserting the wireless neural stimulator device through an inner lumen of the introducer or needle and into the patient's tissue; and withdrawing the introducer from the surgical incision or percutaneous opening.

Abstract: An electrical neuromodulation system configured for minimizing energy consumption of a neuromodulation device includes an external control device configured for receiving input from a user, the neuromodulation device in communication with the external control device, and control/processing circuitry. The control/processing circuitry is configured for automatically (a) adjusting a modulation parameter value (e.g., by a step size) to create a currently adjusted modulation parameter value that decreases the energy consumption of the neuromodulation device, (b) instructing the neuromodulation device to deliver electrical energy to at least one electrode in accordance with the currently adjusted modulation parameter value, (c) determining whether a manual parameter adjustment was made by the user in response to step (b), and (d) if the manual parameter adjustment was not made, deeming the currently adjusted modulation parameter value as a previously adjusted modulation parameter value and repeating steps (a)-(d).

Abstract: Techniques for identifying individual target sites for application of transcranial magnetic stimulation (TMS) to a brain of a patient for treatment of neurological and psychiatric disorders. The identification of the target TMS stimulation sites may be based on using functional connectivity magnetic resonance imaging (fMRI) to determine cortex regions of the brain that are functionally connected to other regions of the brain that may be stimulated to decrease symptoms of depression and other disorders. For example, target stimulation sites may be identified in the left dorsolateral prefrontal cortex (DLPFC) to remotely modulate the activity in a subgenual cingulate region and other limbic regions functionally connected with the DLPFC. TMS may be applied to the patient's head at the identified target TMS sites to treat depression and other neurological and psychiatric disorders.

Abstract: Methods and systems for electrical stimulation can include obtaining a biosignal of the patient; altering at least one stimulation parameter of an electrical stimulation system in response to the biosignal; and delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. In some embodiments, a power spectrum is determined from the biosignal. In some embodiments, the biosignal is at least two different biosignals measured at the same or different locations on the patient and a coherence, correlation, or association between the two biosignal is determined.

Abstract: A neurostimulation system senses electrographic signals from the brain of a patient, extracts features from the electrographic signals, and when the extracted features satisfy certain criteria, detects a neurological event type. A mapping function relates the detected neurological event type to a stimulation parameter subspace and a default stimulation parameter set where the values of the stimulation parameters define an instance of stimulation therapy for the patient. The decision whether to implement a stimulation parameter subspace or a default stimulation parameter set may be informed by integrating other information about a state of the patient. A stimulation parameter subspace or stimulation parameter set may optimized by testing it against various thresholds until certain effectiveness criteria is satisfied. The neurological event type may be one of several electrographic seizure onset types.

Abstract: A method includes determining a measurement indicative of a synchrony between one or more regions of a patient's autonomic nervous system (e.g., the NTS) and one or more regions of the patient's central nervous system (e.g., the thalamus, the cortex) based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the measurement.

Abstract: Methods are provided to treat a neurological disorder in a patient by adjusting connectivity between network nodes in a brain of patient using electrical stimulation. Connectivity between network nodes may be increased by synchronous stimulation at multiple network nodes depending upon the neurological disorder. Also, connectivity may be decreased by asynchronous or randomized stimulation at multiple network nodes depending upon the neurological disorder.

Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

Abstract: Described is a system for enhancing memories during sleep. The system detects, via at least one sensor, brain activity of a user as the user learns a new episode pattern or recalls an episode pattern. The episode pattern is temporally compressed. A specific sleep stage is detected in the user. Upon detection of the specific sleep stage, the system automatically recreates the temporally compressed episode pattern by applying neural stimulation to the user to ensure the consolidation of the episode pattern in the user.

Abstract: A method for implanting a wireless neural stimulator device, the method including: inserting a device through a patient's skin on a lateral side of a patient's neck, wherein the device includes with a proximal end, a distal end, a first opening at the proximal end, a second opening at the distal end, and a lumen extending between the first opening and the second opening; after inserting the device through the patient's skin, advancing the distal end towards a perivascular bundle of the patient until the distal end is proximate to the perivascular bundle; inserting the wireless neural stimulator device through the first opening; and advancing the wireless neural stimulator from the first opening through the lumen until the wireless neural stimulator exits the second opening and is proximate to the vagus nerve such that the neural stimulator is able to stimulate the vagus nerve.

Abstract: An example of a system for comparing neurostimulation waveforms can include a user interface configured to receive user input that at least partially defines a first neurostimulation waveform with at least one of differing pulses and differing pulse intervals, where the user input including at least one received parameter of the first neurostimulation waveform. The system can include a storage device configured to store at least one parameter of at least one second neurostimulation waveform, a comparator configured to compare the at least one received parameter of the first neurostimulation waveform to a corresponding at least one parameter of at least one second neurostimulation waveform stored in a memory, the user interface configured to generate and display to the user an indication of a similarity between the compared parameters.

Abstract: An example of a method performed by an implantable medical device (IMD) to deliver a therapy to a patient may include delivering the therapy to the patient, detecting a trigger that is controlled by the patient or a caregiver to the patient, and determining if at least one feature of the IMD for responding to a trigger is enabled. The IMD may be configured to allow the patient or the caregiver to the patient to enable the at least one feature. The method may further include, when the at least one feature is enabled, automatically implementing the at least one enabled feature in response to the detected trigger, including automatically suspending the therapy in response to the detected trigger and automatically restoring the therapy after a defined period after the detected trigger.

Abstract: A method for reducing overactive bladder syndrome applied with an electrical stimulation device to electrically stimulate a target zone of an organism suffering from overactive bladder syndrome. The electrical stimulation device comprises at least one electrical stimulation unit. The electrical stimulation unit includes at least one first electrode and at least one second electrode. The method includes the following steps. The electrical stimulation unit is placed near the target zone. The electrical stimulation unit generates an electrical stimulation signal and the electrical stimulation signal is introduced to the target zone so as to stimulate the target zone. An electrical field is generated between the first electrode and the second electrode and covers the target zone. The strength of the electrical field ranges from 100 V/m to 1000 V/m.

Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

Abstract: A method includes determining sleep cycle information related to a sleep cycle of a patient based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the sleep cycle information.

Abstract: A signal processing method and system combines multi-scale decomposition, such as wavelet, pre-processing together with a compression technique, such as an auto-associative artificial neural network, operating in the multi-scale decomposition domain for signal denoising and extraction. All compressions are performed in the decomposed domain. A reverse decomposition such as an inverse discrete wavelet transform is performed on the combined outputs from all the compression modules to recover a clean signal back in the time domain. A low-cost, non-drug, non-invasive, on-demand therapy braincap system and method are pharmaceutically nonintrusive to the body for the purpose of disease diagnosis, treatment therapy, and direct mind control of external devices and systems. It is based on recognizing abnormal brainwave signatures and intervenes at the earliest moment, using magnetic and/or electric stimulations to reset the brainwaves back to normality.

Abstract: Aspects include methods, systems and computer program products for evaluating a patient for a movement disorder. The method comprises defining a patient to be evaluated and deploying a unmanned aerial vehicle (UAV) to a location of the patient. The UAV includes a patient evaluation feature and at least one sensor operably coupled to the patient evaluation feature. The UAV is positioned relative to the patient to measure a patient motor characteristic. The patient motor characteristic is measured with the at least one sensor. A movement disorder is determined based at least in part on the measured patient motor characteristic. A signal is transmitted based on the detecting the movement disorder.

Abstract: A method for improved seizure detection includes capturing neural data for a first set of brain regions; calculating inter-region correlations between pairs of the first set of brain regions from the neural data; detecting a period of hyposynchrony from the inter-region correlations; after detecting the period of hyposynchrony, detecting a period of hypersynchrony from the inter-region correlations; and based on a transition from the period of hyposynchrony to the period of hypersynchrony, detecting a first seizure.

Abstract: Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.

Abstract: Herein is described a device and methods-of-use to treat multiple possible causes of sudden neurological dysfunction related to cardiac, cerebrovascular, or brain electrical abnormalities. The device can be employed so as to treat cardiac dysfunction such as arrhythmia and subsequently related dysfunction of the central nervous system such as stroke and seizure. Alternatively, the device can be employed so as to treat cardiac dysfunction simultaneous with treatment of dysfunction of the central nervous system. Finally, the device can be employed so as to augment the effectiveness of treating cardiac dysfunction, namely the restoration of cardiac output and blood flow to the brain, by dilating the arteries of the brain.

Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.

Abstract: An embodiment of a method for solving the inverse problem of electrophysiology and determining a voltage distribution on a surface of a tissue may comprise receiving a plurality of voltages collected by a plurality of electrodes adjacent to the surface, discretizing the problem using a Finite Element Method (FEM) or a Boundary Element Method (BEM), introducing one or more regularization terms to an error minimization formulation, and solving, by a processor, the voltage distribution according to the plurality of voltages and according to the regularization terms. The regularization terms may comprise one or more of a Laplacian smoothness operator, a Tikhonov regularization matrix, a confidence matrix, and a linear operator that interpolates the plurality of electrode voltages to the tissue voltage distribution.

Abstract: Described is a system for weakening traumatic memories using transcranially-applied electro-stimulation. The system uses a recording of spatiotemporally distributed brain activity of a human subject experiencing a traumatic memory to generate a traumatic pattern. Additionally, the system uses a recording of spatiotemporally distributed brain activity of the human subject experiencing a non-traumatic memory to generate an antidote pattern. A required transcranially-applied electro-stimulation is determined to recreate the antidote pattern to block consolidation and reconsolidation of the traumatic memory in the human subject.

Abstract: Systems and methods for detecting complex networks in MRI image data in accordance with embodiments of the invention are illustrated. One embodiment includes an image processing system, including a processor, a display device connected to the processor, an image capture device connected to the processor, and a memory connected to the processor, the memory containing an image processing application, wherein the image processing application directs the processor to obtain a time-series sequence of image data from the image capture device, identify complex networks within the time-series sequence of image data, and provide the identified complex networks using the display device.

Abstract: An implantable subcutaneous electrode system is disclosed. The implantable subcutaneous electrode system may include an electrode body with electrical contacts disposed thereon or integrally formed therein. The electrode body also may include an insulation region defined between the electrical contacts and an aperture defined in the electrode body for receiving an anchoring device. A minimally invasive delivery device and methods for delivery of an implantable electrode system is also provided. The methods may include steps of introducing a needle comprising a cannula and a stylet through a patient's skin, removing the stylet while leaving the cannula in place, introducing an electrode applicator through the cannula, the electrode applicator comprising a hollow driver which receives the electrode assembly, and anchoring the electrode assembly to a bone by driving the hollow driver such that a self-tapping screw within the electrode assembly screws into the bone.

Abstract: The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

Abstract: A system for trigeminal nerve stimulation includes a pulse generator, which includes a user control configured to receive a user adjustment and a microcontroller configured to receive electric stimulation parameters and operate the pulse generator to produce electrical pulses according to the electric stimulation parameters during a treatment session. A method for nerve stimulation includes receiving, by a pulse generator, electric stimulation parameters, and producing, by the pulse generator, electrical pulses according to electric stimulation parameters during a treatment session. The electric stimulation parameters include at least one user-set parameter, which includes a current amplitude that is responsive to the user adjustment of the user control, and at least one physician-set parameter, which includes an upper bound and a lower bound for the current amplitude.

Abstract: An electrical stimulation system includes an implantable control module configured and arranged for implantation in a body of a patient. The implantable control module includes a processor that generates and delivers electrical stimulation pulses or pulse bursts at a pathological frequency or with a temporal separation between pulses or pulse bursts individually selected based on a pre-determined distribution function based on a pre-selected pathological frequency.

Abstract: Systems and methods for treating a neurological disorder comprising determining a first set of neural stimulation parameters capable of treating a first subset of symptoms, determining a second set of neural stimulation parameters capable of treating a second subset of symptoms, and applying a neural stimulation therapy based upon the first set of neural stimulation parameters and the second set of neural stimulation parameters to the patient. The first set of neural stimulation parameters can include electrical stimulation at a first frequency, and the second set of neural stimulation parameters can include electrical stimulation at a second frequency. In other embodiments, a treatment method comprises applying a first neural stimulation therapy to the patient in a continuous or generally continuous manner during a first time interval, and applying a second neural stimulation therapy to the patient in a noncontinuous or interrupted manner following the first time interval.

Abstract: A method for providing electrical stimulation to a user, the method comprising: providing an electrical stimulation device, in communication with a controller, at a head region of the user; with the electrical stimulation device, providing a stimulation treatment having a waveform configured for neuromodulation in the user; with the controller, performing an adjustment to the stimulation treatment, wherein performing the adjustment includes: generating a transformed waveform with application of a transfer function to the waveform, wherein the transfer function scales the waveform and selectively attenuates extreme waveform values while maintaining a frequency characteristic of the waveform in the transformed waveform; and applying the transformed waveform with the electrical stimulation device, thereby modulating the stimulation treatment.

Abstract: An electrical stimulation system for use with a plurality of electrodes implanted within a tissue region comprises a neurostimulator configured for delivering electrical stimulation energy to the plurality of electrodes in accordance with a set of stimulation parameters, thereby injecting a charge into the tissue region, a control device configured for receiving user input to modify the set of stimulation parameters, and controller/processor circuitry configured for, in response to the user input computing a charge injection metric value as a function of a physical electrode parameter and an electrical source parameter for a first set of the electrodes, wherein the electrode set comprises at least two electrodes, comparing the computed charge injection metric value to a safety threshold value, and performing a corrective action based on the comparison.

Abstract: Sensory information can be delivered to a subject mammal, for example, for restoring a sense of cutaneous touch and limb motion to the subject mammal. A biomimetic electrical signal is generated based on (a) a stimulation reference signal applied to a somatosensory region of a nervous system of a reference mammal, (b) a stimulated-response signal acquired from a sensory cortex of the reference mammal in response to application of the stimulation reference signal to the thalamic nucleus, and (c) a natural-response signal acquired from the sensory cortex in response to peripheral touch stimuli and/or peripheral nerve stimulation of the reference mammal. The biomimetic electrical signal is applied to a somatosensory region of a nervous system of the subject mammal to induce an activation response, in a sensory cortex of the subject mammal.