Abstract: Implanted pulse generators with reduced power consumption via signal strength-duration characteristics, and associated systems and methods are disclosed. A representative method for treating a patient in accordance with the disclosed technology includes receiving an input corresponding to an available voltage for an implanted medical device and identifying a signal delivery parameter value of an electrical signal based on a correlation between values of the signal delivery parameter and signal deliver amplitudes. The signal deliver parameter can include at least one of pulse width or duty cycle. The method can further include delivering an electrical therapy signal to the patient at the identified signal delivery parameter value using a voltage within a margin of the available voltage.

Abstract: Systems and methods are provided for treating chronic pain occurring secondarily to subacromial impingement syndrome in a human body. A system is provided to deliver percutaneous electrical stimulation through at least one electrode to neurological motor points of the posterior and middle deltoid muscles to mediate such pain. One-time, continued and/or periodic dosing of treatment methods according to the present invention may result in a change to central nervous system maladaptive neuroplasticity.

Abstract: Methods of treating a psychiatric disorder in a subject are provided which include placing at least one anode on an area of the subject's back over the dorsal spinal cord at the level of one or more of: thoracic vertebra 7 (T7), 8 (T8), 9 (T9), 10 (T10), 11 (T11), and 12 (T12) and lumbar vertebra 1 (L1); placing at least one cathode on an area of the subject's back which is generally rostral with reference to the anode; connecting the anode and the cathode to at least one source of direct and/or alternating electrical current; delivering direct current to the anode for a treatment period of time, the treatment period of time defining a tsDCS and/or tsACS treatment session, thereby modulating spinal input to the brain of the subject, decreasing sympathetic activity and reducing one or more symptoms and/or comorbidities associated with the psychiatric disorder.

Abstract: A closed loop brain stimulation system includes a means for reading electrophysiological signals from the brain; means for reading other biometric signals; means for stimulating the brain; and a control algorithm that dynamically adjusts the parameters of stimulation to minimize a reference utility function that computes the difference between the current and desired brain states, and current and desired biometric states.

Abstract: A device is provide for stimulating neurons. The device includes a stimulation unit that is implantable into a patient's body and that includes multiple stimulation elements for stimulating neurons in a target area of the brain and/or spinal cord of the patient with stimuli. Moreover, the device includes a control unit that actuates the stimulation unit such that multiple groups of stimulation elements generate respective stimuli. In this aspect, each group includes multiple stimulation elements of the stimulation unit with two or more of the groups generating sequences of stimuli in a repetitive manner in a respective time pattern which includes successive cycles. Furthermore, the sequences of stimuli generated by the two or more groups differ in terms of the number of cycles in which the sequence in which the stimulation elements generate the stimuli within one sequence is constant and/or in terms of the duration of respective cycles.

Abstract: Certain aspects of the present disclosure provide systems and methods for configuring and training neural networks. The method includes models of individual neurons in a network that avoid certain biologically impossible or implausible features of conventional artificial neural networks. Exemplary networks may use patterns of local connections between excitatory and inhibitory neurons to provide desirable computational properties. A network configured in this manner is shown to solve a digit classification problem.

Abstract: Methods and devices are described which allow sound waves to be safely be applied to the eyelid of an eye of a patient or through the eyelid to other structures in the eye or to or through structures in the facial region to effect changes to one or more structures in and around the eye or directly through the cornea or sclera to regions of the eye to treat one or more diseases of the eye.

Abstract: A system and method for providing a temporally dynamic model parameter include building a model parameter by minimizing a loss function based on patient measurements taken at a plurality of time points. Temporally related values of the model parameter are identified, using a processor, having a same type of patient measurement taken at different time points. At least one value of the model parameter and temporally related values of the at least one value are selected to provide a temporally dynamic model parameter.

Abstract: Systems and methods for displaying a wiring diagram entail reading a computer aided design (CAD) file representing the wiring diagram. Structures surrounding a wiring bundle represented in the wiring diagram are determined and multiple views are generated showing the structures and the wiring bundle. Descriptive labels are automatically associated with the wiring bundle and the multiple views are saved to a production illustration (PI) file.

Abstract: The disclosure describes a method and system or controlling symptoms of patients suffering from Parkinson's Disease. In some examples, one or more biomarkers indicative of a patient's present symptoms are determined. The biomarkers may be used to control therapy delivered to the patient in a closed-loop manner. In addition, biomarkers may be used as an indication of therapy effectiveness.

Abstract: Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy to stimulate tissue. A prescribed dose of the neurostimulation therapy relates to a therapeutically-effective and safe amount of charge delivered to the stimulated tissue over a period of time. The neural stimulator may include a power supply used to deliver the neurostimulation therapy, and a charge/current monitor configured to monitor a delivered dose of the neurostimulation therapy with respect to the prescribed dose to determine whether the delivered dose is delivering the therapeutically-effective and safe amount of charge to the stimulated tissue over the period of time.

Abstract: The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.

Abstract: The present invention relates to a movement disorder monitor with high sensitivity, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms. The present invention provides for a system and method, which can accurately and repeatably quantify symptoms of movements disorders, accurately quantifies symptoms utilizing both kinetic information and/or electromyography (EMG) data, that can be worn continuously to provide continuous information to be analyzed as needed by the clinician, that can provide analysis in real-time, that allows for home monitoring of symptoms in subject's with these movement disorders to capture the complex fluctuation patterns of the disease over the course of days, weeks or months, that maximizes subject safety, and that provides substantially real-time remote access to data by the clinician or physician.

Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

Abstract: A method for motor training comprising: receiving from one or more sensors an orientation of a head mounted display of the subject; adapting a base video signal representing an avatar of the subject in a virtual reality to be displayed on the head mounted display wherein the avatar comprises a virtual limb corresponding to the limb that is injured; and sending the base video signal to the head mounted display for visualization. The method further comprises in response to a trigger signal from the subject, sending an exercise video signal representing the avatar in the virtual reality performing an exercise to start the visual rendering of the exercise in the head mounted display, even though the corresponding real limb is substantially immobile and provides no input at all. Such exercise is aimed at rehabilitation of the limb from the injury with the virtual limb corresponding to the immobile limb and it is displayed taking into account the orientation of the head mounted display.

Abstract: The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data and/or brain activity mapped data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.

Abstract: The use of a device to measure patient sensory response through the application of an incrementally increased electrical current to the oropharynx.

Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.

Abstract: In a control method for a screen display of a medical imaging system, an image data set of a patient is acquired and a comparison of the acquired image data set is made with a number of pre-stored image data sets, each of which is stored with layout parameters for the screen display associated therewith. Display of the acquired image data set take place with the layout parameters of the pre-stored image data set that has the greatest similarity with the acquired image data set.

Abstract: Systems and related methods for enhancing learning of a motor task are described. The system controls delivery of an example or prompt to the subject via one or more of an audio, video, or other output device. A learning enhancing transcutaneous neural stimulus is delivered in association with the example or prompt. Electrical control circuitry controls timing of delivery of neural stimuli and prompts or examples. The system may be implemented in connection with a personal computing device, for example.

Abstract: A medical device stores a set of stimulation profiles, wherein each stimulation profile of the set of stimulation profiles is associated with a set of values for stimulation parameters; selects from the set of stimulation profiles, one or more active stimulation profiles; produces, by a stimulation generator, multiple electrical pulses based on the one or more active stimulation profiles; and separately controls parameter values of respective individual pulses of the multiple pulses.

Abstract: An implantable device includes one or more electrodes to sense an electrical signal from a brain and a waveform analyzer to identify a half wave in the electrical signal; determine an amplitude and a duration of the half wave; determine if the amplitude satisfies a half wave amplitude criterion defined by a set of amplitude parameters comprising a minimum half wave amplitude and a maximum half wave amplitude; determine if the duration satisfies a half wave duration criterion defined by a set of duration parameters comprising a minimum half wave duration and a maximum half wave duration; and identify the half wave as a qualified half wave when the half wave amplitude criterion and the half wave duration criterion is satisfied. A neurological event may be detected based on one or more qualified half waves and electrical stimulation therapy may be delivered to the brain in response to the detection.

Abstract: Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.

Abstract: Information relevant to making clinical decisions for a patient is identified based on electrical activity records of the patient's brain and electrical activity records of other patients' brains. A deep learning algorithm is applied to an electrical activity record of the patient, i.e., an input record, and to a set of electrical activity records of other patients, i.e., a set of search records, to obtain an input feature vector of the patient and a set of search feature vectors, each including features extracted by the deep learning algorithm. A similarities algorithm is applied to the input feature vector and the set of search feature vectors to identify a subset of search records most like the input record. Clinical information associated with one or more search records in the identified subset of search records is extracted from a database and used to make decisions regarding the patient's neuromodulation therapies.

Abstract: Data related to the adherence of a patient to a therapy regime can be collected from multiple medical devices, each of which may have an incomplete data set with data entries associated with times. Each incomplete data set represents a portion of a complete data set. The data sets can be integrated to create a complete data set with data entries from each incomplete data set being arranged in a temporal sequence with respect to one another. A report may be generated, the report having the data entries of the complete data set or a function of the data entries of the complete data set.

Abstract: A method for improving subject's spatial cognition and spatial memory includes presenting spatial information to the person through non-visual means, parcellating the image to enhance understanding of the nature and relationships of the image components to augment image memory, drawing the image, detecting and encoding the errors in the drawing, and providing interactive feedback based on the individual's drawing performance. The methodology includes audio-haptic feedback to present the spatial image information non-visually using an audible signal that varies as a function of the distance of the finger/stylus from the regions of a display that express the image features.

Abstract: An external unit for an implantable neuro stimulator system and a method of operating the same, comprising an external coil inductively couplable to an implant coil of an implantable neural stimulator unit when in close proximity to each other. An RF-signal generating module for generating and outputting an RF-signal to the coil for inductive power and/or data transfer to the implantable neural stimulator unit, a measurement unit connected to the coil for measurement of an electrical parameter at the coil and a controller connected to the measurement unit and comprising a comparator and a storage for storing the electrical parameter.

Abstract: Systems and methods are provided for an implantable neurostimulator system comprising an array of microelectrodes, a pair of current drivers, and a dynamic current allocation network (DCAN). Each current driver in the pair of current drivers is configured to deliver a respective portion of an electrical signal to the array of microelectrodes to deliver the desired electrical stimulation through the array of microelectrodes to the subject. The DCAN is coupled to the pair of current drivers and the array of microelectrodes to selectively electrically connect each of the pair of the current drivers to individual microelectrodes in the array of microelectrodes to deliver the electrical signal to selective collections of less than all microelectrodes in the array of microelectrodes to deliver the desired electrical stimulation. The pair of current drivers and the DCAN are arranged in respective or a common housing configured to be implanted into the subject.

Abstract: An energy acquisition and power supply system is provided. The power supply system includes a plurality of power elements, each of the power elements including a transistor capable of conduction path switching, a current regulator having a dynamic substrate selection circuit and a reverse leakage current suppression circuit as well as a voltage regulator, wherein the dynamic substrate selection circuit selects a substrate potential of the transistor capable of conduction path switching dynamically to reduce a substrate leakage current of the transistor capable of conduction path switching, and the reverse leakage current suppression circuit is utilized for switching the power element at a local end to reduce transient reverse leakage current and current consumption of the power element at the local end for an input voltage, such that an output current for the power element at the local end is maximized.

Abstract: Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.

Abstract: A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

Abstract: In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.

Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.

Abstract: Disclosed in an improved medical implantable device system including an improved external charger that is able to communicate with an external controller and IPG using the communication protocol (e.g., FSK) used to implement communications between the external controller and the implant. The external controller as modified uses its charging coil to charge the implant, and also to communicate with the other devices in the system. As such, the external charger is provided with transceiver circuitry operating in accordance with the protocol, and also includes tuning circuitry to tune the coil as necessary for communications or charging. Communication or charging access to the charging coil in the external charger is time multiplexed. The disclosed system allows charging information to be provided to the user interface of the external controller so that it can be reviewed by the user, who may take corrective action if necessary.

Abstract: A computing device executes a software program that communicates various deep brain stimulation (DBS) routines to a neurostimulator. The software program generates a graphical user interface (GUI) that receives inputs that are indicative of a patient's response to the various DBS routines. The GUI further includes a representation of each of one or more electrode leads that are connected to the neurostimulator. Based on the patient response inputs, one or more symbols that are indicative of an effectiveness of the stimulation routines are displayed at positions on the lead representations that correspond to parameters of the stimulation routines.

Abstract: A method for desynchronizing a pathological neural oscillations, includes identifying a first subpopulation of the neurons involved in the pathological neural oscillation that are in alignment with each other within a predetermined angular stimulation range, and a second subpopulation that are both (A) in alignment with each other within the predetermined angular stimulation range, and (B) out of alignment with the first neurons by at least the predetermined angular stimulation range, and applying electrical stimuli to the first and second subpopulations through scalp electrodes, the electrical stimuli being out of phase with the pathological neural oscillations for desynchronizing the pathological neural oscillations.

Abstract: An apparatus for treating neurological disorders comprising at least one electrode implantable in a patient's brain and a processing and stimulation device connected to the at least one electrode. The processing and stimulation device comprises at least one stimulation module adapted to generate a stimulation signal characterised by a plurality of parameters; at least one acquisition module adapted to acquire a signal characteristic of cerebral activity and determine its power in at least one frequency band; and at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is configured to set the at least one parameter of the stimulation signal differently dependent on a plurality of power ranges, by keeping the parameter within a predetermined stimulation range.

Abstract: Described is a system to accelerate memory consolidation using a steerable transcranial intervention. During operation, the system generates a unique transcranial and steerable stimulation tag to associate with memory of a task or event. Once the tag is generated, the system activates a plurality of electrodes (e.g., as few as four) to apply the unique transcranial stimulation tag during the occurrence of the event or task to be consolidated.

Abstract: Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events.

Abstract: Representative embodiments are directed to detecting neurological activity in a patient. The detection of neurological activity includes identifying cross-frequency coupling and determining whether the cross-frequency coupling is physiological or pathological. When pathological cross-frequency coupling is detected, neurostimulation of one or more sites is applied. In some embodiments, an implantable pulse generator is adapted to analyze neural activity for pathological cross-frequency coupling and to provide electrical stimulation in response to the detected pathological cross-frequency coupling.

Abstract: A computer-assisted method to timely provide notifications of treatments, the method including receiving de-identified longitudinal medical records, each de-identified longitudinal medical record representing a record of a different anonymized patient and encoding information identifying a treatment received by the anonymized patient and receiving notification data including notification records, each notification record encoding information identifying a channel through which the notification was provided. The method includes determining a first channel impact model representing an impact of a notification provided through a first channel on a treatment being received, a second channel impact model representing an impact of a notification provided through a second channel on a treatment being received, and determining a multi-channel impact model representing an impact of notifications being provided through both the first channel and the second channel on a treatment being received.

Abstract: An example of a system for modulating blood pressure may include a blood pressure monitoring circuit, a blood pressure modulation device, and a control circuit. The blood pressure monitoring circuit may be configured to sense signals and generate one or more blood pressure parameters indicative of the blood pressure and/or a vascular resistance and one or more activity parameters indicative of an activity level and/or a postural change using the sensed signals. The blood pressure modulation device may be configured to deliver a therapy modulating the blood pressure. The control circuit may be configured to control the therapy using therapy parameters, receive the one or more blood pressure parameters and the one or more activity parameters, analyze changes in the one or more blood pressure parameters that are correlated to changes in the one or more activity parameters, and adjust the therapy parameters using an outcome of the analysis.

Abstract: A system may include electrodes on at least one lead configured to be operationally positioned for use in modulating a volume of neural tissue, a neural modulation generator configured to deliver energy using at least some electrodes to modulate the volume of neural tissue, a programming system configured to program the programmed modulation parameter set, including determine electrode fractionalizations for the electrodes based on a target multipole. The programmed parameter set may include the determined electrode fractionalizations. The target multipole may be used to determine electrode fractionalizations having at least three target poles that directionally and progressively stack fractionalizations of target poles to provide a linear electric field over the volume of tissue. The neural modulation generator may be configured to use the programmed modulation parameter set to provide the linear electric field over the volume of tissue.

Abstract: The invention provides transcranial electrostimulation by combining transcranial direct current stimulation (tDCS) and theta burst stimulation (TBS) to achieve an unexpected therapeutic effect in various brain or neural diseases. Accordingly, the invention provides a mode of direct current with biphasic square wave pulses in the treatment of brain or neural diseases. Also provided are methods of employing the transcranial electrostimulation of the invention and applications of the transcranial electrostimulation of the invention.

Abstract: A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture).

Abstract: A method and system of providing therapy to a patient using electrodes implanted adjacent tissue. The method comprises regulating a first voltage at an anode of the electrodes relative to the tissue, regulating a second voltage at a cathode of the electrodes relative to the tissue, and conveying electrical stimulation energy between the anode at the first voltage and the cathode at the second voltage, thereby stimulating the neural tissue. The system comprises a grounding electrode configured for being placed in contact with the tissue, electrical terminals configured for being respectively coupled to the electrodes, a first regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, a second regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, and control circuitry configured for controlling the regulators to convey electrical stimulation energy between the anode and cathode.

Abstract: Systems and methods for beacon device fleet management are provided. One example system includes a plurality of beacon devices, a plurality of mobile computing devices, a fleet management system, and a fleet owner computing devices. One example method includes receiving, by the fleet management system, a device status request from the fleet owner computing device. The fleet management system determines one or more operational statuses of beacon devices owned by the fleet owner and transmits data indicative of the one or more operational statuses to the fleet owner computing device. The operational statuses can include a current detection status (e.g., online or offline), a location status, a power source status, and/or other operational parameters.

Abstract: A hearing aid system includes an electric audio signal input, an audio input signal processing unit that is configured to process electric audio input signals in the first processing mode or in the second processing mode and to provide an electric audio output signal, and an output transducer. The hearing aid system further includes an audio input signal analysing unit that is configured to continuously monitor the electric audio input signal as a function of time and to determine and to provide a number of audio signal values each representing a characteristic of the electric audio input signal at a given time instance. The hearing aid system further includes a plurality of electrodes that are configured to be brought into contact with the skin of a user and which are configured—when operationally mounted to receive an electric signal that rep-resents a user's brain activity and to provide a respective EEG-related signal.

Abstract: Devices, systems, and methods pertain to planning and providing guidance for a cranial based implantation of an implantable medical device or devices. The collection of data, such as data pertaining to the skull of the patient, the scalp of the patient, the vascular structure or neurological structures in the head of the patient, is performed. The data may be in the form of images, such as images generated by X-ray, magnetic resonance imaging, CT-scan and fluoroscopy. A surgeon can use the collected data to determine, for example, whether the patient is a candidate for a cranial implantation, whether the patient's skull and scalp can support the implantation, what configuration of device should be implanted, where the device should be implanted, and how the surgical incisions should be made.

Abstract: The present disclosure relates generally to systems, methods, and devices for closed loop deep brain stimulation. In particular, a neural signal is measured and provided to software. The software includes a feature generator and a brain network model that takes the neural signal and estimates other neural signals that are not directly measured, and operates as a model of the brain. The software determines a stimulation signal to be sent to stimulating electrodes. Estimated signals by the brain network model are continuously compared to actual signals from the brain. The closed loop feedback system advantageously allows for electrical stimulation levels and patterns to be continuously updated while delivered to a patient.