Including Bioactive Coating Patents (Class 623/23.57)
  • Patent number: 10568741
    Abstract: Systems, devices, and methods are provided for orthopedic implants. The implants may include a base member, such as an acetabular shell or an augment, that is configured to couple with an augment, flange cup, mounting member, or any other suitable orthopedic attachment. Any of the implantable components may be include one or more porous surfaces. The porous surface may be textured by protrusions that connect to and extend from the surface. The sizes and concentration of the protrusions may be varied for specific applications to accommodate different implants and patient anatomies. A porous implant may also include one or more internal or external solid portions that strengthen the implant.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: February 25, 2020
    Assignee: Smith & Nephew, Inc.
    Inventors: Justin Steve Conway, Ryan L. Landon, Jeffrey Joel Shea
  • Patent number: 10335513
    Abstract: A coating for a roughened metal surface of an implantable medical device includes a poly(ethylene glycol) disposed on at least a portion of the roughened metal surface, wherein the poly(ethylene glycol) is covalently bonded directly to the roughened metal surface.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: July 2, 2019
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Danielle Frankson, Joseph T. Delaney, Jr., Mary M. Byron, Adam McGraw, David R. Wulfman, Kylee M. Lersch
  • Patent number: 10241258
    Abstract: A biocompatible and biodegradable polymeric step-index optical fiber includes a core and a cladding around the core. The core is made from a core material fabricated by bonding a citric acid and at least a first monomer using a synthesis process. The cladding is made from a cladding material fabricated by bonding the citric acid and at least a second monomer using the synthesis process. The core has a refractive index higher than that of the cladding, while a difference between an initial modulus of the core and the cladding is preferably less than 30% and a difference between the biodegradation rates of the core and cladding is preferably less than 30% after about 4 weeks. Optical properties of the core and cladding are tunable by adjusting monomer ratios, choices of monomers or cross-linking degrees.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: March 26, 2019
    Assignee: The Penn State Research Foundation
    Inventors: Jian Yang, Zhiwen Liu, Dingying Shan, Chenji Zhang
  • Patent number: 9744263
    Abstract: The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: August 29, 2017
    Assignee: ASTRA TECH AB
    Inventors: Christina Gretzer, Ingela Petersson
  • Patent number: 9650707
    Abstract: A monolithic titanium alloy having, in a temperature range (?T) and at atmospheric pressure: an outer peripheral zone of a microstructure having a modulus of elasticity (E1) and possessing superelastic properties in the range (?T), and a core of a microstructure having a modulus of elasticity (E2), and possessing elastic properties in the range (?T); the microstructures and being different from one another, and the modulus of elasticity (E1) being lower than said modulus of elasticity (E2).
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: May 16, 2017
    Assignee: Centre National de la Recherch Scientifique
    Inventors: Frédéric Prima, Sophie Nowak
  • Patent number: 9549791
    Abstract: To obtain improved bio-affinity and high bone attachment in an implant body, a method of manufacture for the implant body, and a dental implant. The implant body is fixed in a contact configuration to bone, and includes the base material formed from zirconia, and a surface layer formed on the surface of the base material and having a lower hardness than the base material. Therefore, in addition to having superior mechanical strength due to the zirconia base material, the soft and flexible surface layer functions as a buffer layer to mitigate the difference in the degree of hardness between the bone and the base material, and therefore the soft surface further improves the bone adhesion characteristics.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: January 24, 2017
    Assignee: Nanto Seimitsu Co., Ltd.
    Inventor: Teruo Ishiwata
  • Patent number: 9523144
    Abstract: Mechanical devices such as prosthetic knees, hips, shoulders, fingers, elbows, wrists, ankles, fingers and spinal elements when implanted in the body and used as articulating elements are subjected to wear and corrosion. These prosthetic implants are usually fabricated in modular form from combinations of metallic materials such as stainless steels, Co—Cr—Mo alloys, and Ti—Al—V alloys; plastics such as ultra high molecular weight polyethylene (UHMWPE); and ceramics such as alumina and zirconia. As the articulating surfaces of these materials wear and corrode, products including plastic wear debris, metallic wear particles, and metallic ions will be released into the body, transported to and absorbed by bone, blood, the lymphatic tissue, and other organ systems. The polyethylene wear particles have been shown to produce long term bone loss and loosening of the implant.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: December 20, 2016
    Inventors: Arnold H. Deutchman, Robert J. Partyka, Robert J. Borel
  • Patent number: 9421300
    Abstract: Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 23, 2016
    Assignee: University of Utah Research Foundation
    Inventor: Russell J. Stewart
  • Patent number: 9168142
    Abstract: Systems and methods for providing tissue-interfacing surface layers with increased roughness can be attained by providing a metallic powder to a machined or previously machined tissue-interfacing surface of a porous foam structure. The metallic powder can have sizes and characteristics such that the porous structure can have an increased roughness at the tissue-interfacing machined surface while inhibiting the occlusion of the open pores in the porous metallic foam structure.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: October 27, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Carie Fincher Alley, Laura J. Gilmour
  • Patent number: 9005286
    Abstract: The present invention involves tissue engineering constructs made from a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and bioceramic particles exposed on its surface using a gas foaming particle leaching (GF/PL) method and infused with collagen. Methods and apparatus for of forming scaffolds are also disclosed.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: April 14, 2015
    Assignee: Thierry Giorno
    Inventor: Thierry Giorno
  • Patent number: 8932366
    Abstract: A porous structure and a porous assembly resulted therefrom for implants allow a tissue to go through and attach for ingrowth, thereby achieving an ideal fixing effect. At least one porous structure is provided with a plurality of geometric-contoured apertures defined by walls. At least one channel is disposed on the apertures or the walls along a reference axis so that the adjoining apertures are intercommunicated, and the porous structures are connected and/or stacked with each other to contribute a porous assembly.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: January 13, 2015
    Inventor: Grant Lu-Sun Shih
  • Patent number: 8911500
    Abstract: Methods and apparatus of providing a joint replacement parts with a pharmaceutical delivery system is provided. The pharmaceutical delivery system is placed within the joint replacement parts to provide, over a period of time, sustained release of a controlled concentration of pharmaceuticals within the joint space of the joint replacement and to produce a local or systemic physiological of pharmacological effect.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 16, 2014
    Inventor: Abraham Lin
  • Publication number: 20140358238
    Abstract: A bioabsorbable plug implant, suitable for bone tissue regeneration, comprising a first portion, and a second portion extending outwardly from the first portion, the first and second portions formed from expandable material. A method for bone tissue regeneration comprising the steps of: providing a bioabsorbable plug implant, wherein the implant comprises a first portion and a second portion extending outwardly from the first portion, the first and second portions formed from expandable material; inserting the second portion into a defect or gap of a bone, the first surface engaging the outside contour of the defect or gap; allowing the plug implant to contact body fluids, thereby expanding the size of the plug implant so that the plug fits into the defect or gap.
    Type: Application
    Filed: March 24, 2014
    Publication date: December 4, 2014
    Inventors: Swee Hin TEOH, Kim Cheng TAN, Dietmar HUTMACHER, Thiam Chye LIM, Jan-Thorsten SCHANTZ, Ning CHOU
  • Publication number: 20140350680
    Abstract: The present invention relates to a process for modifying the surface morphology of a medical device. The modified surface has, among other advantageous properties, an improved capacity for sorption or conjugation of a variety of bioactive agents, the addition of which will turn the medical device into a localized drug delivery system.
    Type: Application
    Filed: December 22, 2012
    Publication date: November 27, 2014
    Inventors: Dang Quang Svend Le, Muwan Chen, Menglin Chen, Anette Overgaard Baatrup, Cody Eric Bünger, Helle Lysdahl, Jørgen Kjems, Morten Østergaard Andersen, Flemming Besenbacher
  • Publication number: 20140288662
    Abstract: The present invention comprises devices, systems, and methods for elongating bone using an extension implant having a first end and a second end. The first end of the extension implant is inserted into an opening in the live bone and the second end of the extension implant is combined with an enlarged implant. A plurality of channels extend through the components to serve as conduits for delivering fluids and physiological signals which induce bone formation. Some embodiments include a subcutaneous cage assembly for helping to support the implant as the bone heals around it.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 25, 2014
    Applicant: Osteoceramics, Inc.
    Inventor: Thomas D. McGee
  • Publication number: 20140277571
    Abstract: An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapour deposition.
    Type: Application
    Filed: August 30, 2012
    Publication date: September 18, 2014
    Applicant: IHI IONBOND AG
    Inventors: Maria Pettersson, Håkan Engqvist, Johanna Olofsson, Lars Hultman
  • Patent number: 8815328
    Abstract: Methods are presented for a continuous, two-step, phase sequenced deposition of hydroxyapatite film over the surface of the substrate.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: August 26, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Richard E. Riman, Alexander Burukhin, Eugene Zlotnikov, Dan Haders
  • Publication number: 20140222160
    Abstract: Disclosed herein is a method of using a medical implant in a subject. The method comprises treating a medical implant with ultraviolet light (UV) in a closed environment, causing the temperature of the medical implant to be between room temperature (Rt) and about 37° C., and immediately, and placing the implant of a temperature from about the room temperature to about 37° C. in a site in need within the subject.
    Type: Application
    Filed: January 8, 2014
    Publication date: August 7, 2014
    Applicant: The Regents of the University of California
    Inventor: Takahiro OGAWA
  • Patent number: 8784499
    Abstract: Devices and methods for treating or repairing a tissue or organ defect or injury are provided. The devices can include tissue scaffolds produced from acellular tissue matrices and polymers, which have a stable three-dimensional shape and elicit a limited immunologic or inflammatory response.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: July 22, 2014
    Assignee: LifeCell Corporation
    Inventors: Rick Owens, Wendell Sun, Mike Liu, Yong Mao
  • Patent number: 8778822
    Abstract: The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: July 15, 2014
    Assignee: Cabertech, Inc.
    Inventor: Kenneth A. McGowan
  • Patent number: 8703293
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: April 22, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Patent number: 8673018
    Abstract: A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: March 18, 2014
    Assignee: AMx Tek LLC
    Inventor: James A. Walls
  • Patent number: 8652214
    Abstract: To improve a cartilage replacement implant for the biological regeneration of a damaged cartilage area of articular cartilage in the human body, comprising a cell carrier which has a defect-contacting surface for placement on the damaged cartilage area and is formed and designed for colonization with human cells, so that after implantation of the cartilage replacement implant, formation of a gap between adjacent contact surfaces of the implant and surrounding recipient tissue is minimized, it is proposed that the cell carrier rest with surface-to-surface contact on a carrier and be joined to the carrier at a cell carrier surface that faces away from the defect-contacting surface. A method for producing a cartilage replacement implant is also proposed.
    Type: Grant
    Filed: June 9, 2011
    Date of Patent: February 18, 2014
    Assignee: Tetec Tissue Engineering Technologies AG
    Inventors: Juergen Fritz, Christoph Gaissmaier, Wilhelm K. Aicher
  • Patent number: 8628584
    Abstract: A transcutaneous prosthesis includes a first component shaped for implantation into a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion.
    Type: Grant
    Filed: January 3, 2006
    Date of Patent: January 14, 2014
    Assignee: University College London
    Inventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
  • Patent number: 8623526
    Abstract: Disclosed are a gradient bioceramic coating comprising a rare earth oxide, a broadband laser method for preparing the bioceramic coating, and the use of the bioceramic coating in the field of medical materials.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: January 7, 2014
    Assignee: Guizhou University
    Inventors: Qibin Liu, Wenfei Li, Ling Wu
  • Publication number: 20130297038
    Abstract: Bone implant compositions and methods are provide that have an outer surface, the outer surface comprising demineralized bone and having a cavity disposed in the outer surface, the cavity having a demineralized bone material coated therein; and an inner surface of the bone implant comprising cortical bone, the inner surface contacting the outer surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 7, 2013
    Applicant: Warsaw Orthopedic, Inc. An Indiana Corporation
    Inventor: William F. McKay
  • Publication number: 20130282136
    Abstract: A method of preparing a preformed bone shape for implantation provides irradiating at least a portion of a preformed bone shape by a Neutral Beam derived from a GCIB, and the preformed bone shape so irradiated.
    Type: Application
    Filed: June 20, 2013
    Publication date: October 24, 2013
    Inventors: Joseph Khoury, Laurence B. Tarrant, Sean R. Kirkpatrick, Richard C. Svrluga, Stephen M. Blinn
  • Patent number: 8545927
    Abstract: The invention provides biomatrix compositions comprising cross-linked lactoferrin, either alone or in combination with other organic or inorganic components. Also provided are methods of making and using the biomatrix compositions. As described herein, cross-linked lactoferrin biomatrix retains the bioactivities of the lactoferrin molecule. The biomatrix composition can act as a matrix for cell adhesion and growth and is particularly useful in musculoskeletal tissue regeneration. The biomatrix compositions can be pre-formed or injectable and can act as a cell, drug or protein delivery vehicle.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: October 1, 2013
    Assignee: University of Connecticut
    Inventor: Lakshmi Sreedharan Nair
  • Publication number: 20130245783
    Abstract: The invention relates to an implant with a coating (23) which releases silver ions in the human body and as a result has antimicrobial action. According to the invention, a first surface component of the coating (23) is formed by an anode material (25). A second surface component of the coating (23) is formed by a cathode material (26). The cathode material is higher in the electrochemical voltage series than the anode material (25). The cathode material (26) and the anode material (25) are connected to one another in an electrically conductive manner. Together with the body electrolyte in the environment of the implant, the anode material (25) and the cathode material (26) form a multitude of local galvanic elements. The antimicrobial action of the coating (23) is improved as a result.
    Type: Application
    Filed: April 13, 2011
    Publication date: September 19, 2013
    Applicant: DERU GMBH
    Inventor: Ulrike Thull
  • Publication number: 20130218264
    Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
    Type: Application
    Filed: August 22, 2012
    Publication date: August 22, 2013
    Inventors: Richard C. Svrluga, Sean R. Kirkpatrick, Stephen M. Blinn
  • Patent number: 8512416
    Abstract: A transdermal intraosseous device includes a transdermal adapter for an external prosthetic device for a bone of a patient and a bone fixator including a distal portion coupled to the transdermal adapter and a proximal portion for anchoring into the bone. The transdermal adapter includes a dome-shaped portion for transcutaneous implantation and an external shaft extending from the dome-shaped portion. A dermal transition structure is configured to include a controlled roughness gradient from the external shaft to the dome-shaped portion and configured for use in infection control at a dermis layer of the patient.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: August 20, 2013
    Assignee: Biomet Manufacturing, LLC
    Inventors: Joshua R. Porter, Troy W. Hershberger
  • Publication number: 20130211540
    Abstract: One aspect of the present invention relates to a multilayer surgical membrane. The surgical membrane can include a substantially fluid impermeable outer layer, an inner layer that includes a plurality of fenestrae, and a middle region disposed between the inner and outer layers. The middle region can include at least one channel that extends through the middle region. The middle region can have a first surface in contact with the inner layer. The at least one channel can imbibe fluid under a compressive or tensile load and the fenestrae can deform to exude fluid under the load.
    Type: Application
    Filed: March 7, 2011
    Publication date: August 15, 2013
    Inventors: Melissa Knothe Tate, Ulf Knothe
  • Publication number: 20130197660
    Abstract: Implantable devices having antibacterial activity for preventing periprosthetic infections and for improving osteointegration capacity are provided. Methods for making and using such devices are also provided.
    Type: Application
    Filed: March 24, 2011
    Publication date: August 1, 2013
    Applicant: NOBIL BIO RICERCHE S.r.l.
    Inventors: Daniele Bollati, Marco Morra, Clara Cassinelli, Giovanna Cascardo
  • Patent number: 8475536
    Abstract: Biomedical implants (e.g., orthopedic implants) with modified surfaces that can enhance a cement bond's strength (e.g., tensile, shear, and/or fatigue) are disclosed, along with methods of manufacturing and using such implants. The implants can exhibit a variety of physical, chemical, or process-derived features which can enhance cement bonding. For instance, the implant surface can exhibit particular roughness values, and/or be substantially free of non native material. Processes for producing such implants can include providing a first roughened implant surface, which can be produced, for example, by particle blasting. A treatment formulation can be applied to the first roughened surface to create a second roughened surface that exhibits enhanced cement bonding properties relative to the first roughened surface. In some instances, the first roughened surface and the second roughened surface can exhibit substantially similar Ra values. The second roughened surface can exhibit a negative Rsk value.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: July 2, 2013
    Assignee: DePuy Synthes Products, LLC
    Inventors: Weidong Tong, Steve Leisinger, Lawrence Salvati, John Bonitati
  • Publication number: 20130166040
    Abstract: The invention provides reagents and method for replacing teeth lost to periodontitis and other diseases and disorders resulting in tooth loss, and provides materials and methods that result in replacement or reimplanted teeth that have a higher rate of stable, long-term implantation status. In a first aspect, the invention provides an implantable tooth, comprising a natural or artificial animal tooth having a microporous tooth root surface, wherein said tooth root surface comprises a plurality of periodontal ligament progenitor cells coating all or a portion of the tooth root. In particular embodiments, the tooth is a natural tooth, especially a human tooth. In alternative embodiments, the tooth is an artificial tooth. In particular embodiments, the tooth comprises a periodontal ligament progenitor cell coating that further comprises one or a plurality of extracellular matrix proteins. In a second aspect, the ivnention provides kits for preparing an implantable tooth.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 27, 2013
    Applicant: The Board of Trustee of the University of Illinois
    Inventor: Thomas G.H. Diekwisch
  • Publication number: 20130138221
    Abstract: The disclosed methods, uses and articles are in the field of orthopedic and dental implants. In particular, the disclosure relates to compositions and methods for improving the osseointegration of such implants.
    Type: Application
    Filed: April 14, 2011
    Publication date: May 30, 2013
    Applicant: Novartis AG
    Inventors: Uwe Junker, Michaela Kneissel, Ina Kramer, Falko Schlottig
  • Publication number: 20130138211
    Abstract: A composition of matter comprising a water-swellable IPN or semi-IPN including a hydrophobic thermoset or thermoplastic polymer and an ionic polymer, articles made from such composition and methods of using such articles. The invention also includes a process for producing a water-swellable IPN or semi-IPN from a hydrophobic thermoset or thermoplastic polymer including the steps of placing an ionizable monomer solution in contact with a solid form of the hydrophobic thermoset or thermoplastic polymer; diffusing the ionizable monomer solution into the hydrophobic thermoset or thermoplastic polymer; and polymerizing the ionizable monomers to form a ionic polymer inside the hydrophobic thermoset or thermoplastic polymer, thereby forming the IPN or semi-IPN.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 30, 2013
    Inventors: David Myung, Michael J. Jaasma, Lampros Kourtis
  • Patent number: 8449622
    Abstract: An osteochondral implantable device is provided, comprising an upper cap and at least one insert comprising a non-polymeric material in physical contact with the upper cap, said lower insert comprising at least one non-polymeric material, wherein the porosity of the upper cap is greater than the porosity of the insert and the Young's modulus of the upper cap is smaller than the Young's modulus of the insert.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: May 28, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130110252
    Abstract: A medical implant for cartilage repair at an articulating surface of a joint includes a contoured, substantially plate shaped, implant body and at least one extending post. The implant body has an articulate surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the articulate and bone contact surfaces face mutually opposite directions and the bone contact surface is provided with the extending post. A cartilage contact surface connects the articulate and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The cartilage contact surface has a coating that substantially only includes a bioactive material.
    Type: Application
    Filed: May 24, 2011
    Publication date: May 2, 2013
    Inventors: Nina Bake, Leif Ryd
  • Patent number: 8414654
    Abstract: An implant device for humans or mammals has a body structure having an exposed surface and one or more selected portions of the exposed surface having a bone formation enhancing 3-dimensional pattern. The exposed surface can be on exterior portions of the body structure or internal portions of the body structure or both. The one or more selected portions of the exposed portions having the bone formation enhancing 3-dimensional patterns are in the external exposed surfaces or in the internal exposed surfaces or both internal and external exposed surfaces.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 9, 2013
    Assignee: Amendia, Inc.
    Inventor: Timothy Ganey
  • Publication number: 20120310366
    Abstract: Implantable medical devices and methods are provided that have one or more statins disposed therein. The medical devices may be implanted at near or in a bone defect to enhance bone growth. In some embodiments, the medical device provided allows for sustain release of the statin and facilitates bone formation and repair of the fracture site.
    Type: Application
    Filed: June 5, 2012
    Publication date: December 6, 2012
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Ping Li, Jeffrey C. Marx, William F. McKay
  • Patent number: 8323722
    Abstract: The present invention provides polymeric substrates comprising a biocompatible coating and methods of preparation thereof. In particular, the coating may be a ceramic material, especially a calcium phosphate material, which may be functionally graded. The invention provides the ability to apply high quality coatings to polymeric substrates without damaging the substrate (e.g., melting the polymeric material). The functionally graded coating can provide crystalline calcium phosphate near the coating interface with the substrate and provide amorphous calcium phosphate at the outer surface of the coating.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: December 4, 2012
    Assignee: North Carolina State University
    Inventor: Afsaneh Rabiei
  • Publication number: 20120283839
    Abstract: A surgical implant device capable of conforming to a variety of surface topographies facilitates the growth and regeneration of site to which the device is applied. The device employs a plurality of elongate members supporting a column of discrete, rotatable elements in contact with each adjacent element. Anchor plates secure the respective ends of the elongate members, such anchor plates attachable to bone. The implant device provides and ordered array of individually rotatable elements to form a surface that permits bodily fluids to pass therethough.
    Type: Application
    Filed: July 18, 2012
    Publication date: November 8, 2012
    Inventor: Walter E. Strippgen
  • Publication number: 20120271418
    Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.
    Type: Application
    Filed: February 28, 2012
    Publication date: October 25, 2012
    Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
  • Patent number: 8231685
    Abstract: To improve a cartilage replacement implant for the biological regeneration of a damaged cartilage area of articular cartilage in the human body, comprising a cell carrier which has a defect-contacting surface for placement on the damaged cartilage area and is formed and designed for colonization with human cells, so that after implantation of the cartilage replacement implant, formation of a gap between adjacent contact surfaces of the implant and surrounding recipient tissue is minimized, it is proposed that the cell carrier rest with surface-to-surface contact on a carrier and be joined to the carrier at a cell carrier surface that faces away from the defect-contacting surface. A method for producing a cartilage replacement implant is also proposed.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: July 31, 2012
    Assignee: Tetec Tissue Engineering Technologies AG
    Inventors: Juergen Fritz, Christoph Gaissmaier, Wilhelm Karl Aicher
  • Patent number: 8215310
    Abstract: An implant suitable for treatment of treatment of vaginal and/or uterine prolapse and/or pelvic floor reconstruction. The implant comprises a vaginal support member substantially sized or shaped to the portion of the vaginal wall to be supported and at least two extension portions projecting from the support member, wherein at least one extension portion has fixation means for anchoring the extension portion into pelvic paravaginal fibro-fatty issue without being faxed into defined structural tissues. A method of treating treatment of vaginal and/or uterine prolapse and/or pelvic floor reconstruction using the implant is also provided.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 10, 2012
    Assignee: Coloplast A/S
    Inventor: James Browning
  • Patent number: 8206843
    Abstract: Disclosed are a gradient bioceramic coating comprising a rare earth oxide, a broadband laser method for preparing the bioceramic coating, and the use of the bioceramic coating in the field of medical materials.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: June 26, 2012
    Assignee: Guizhou University
    Inventors: Qibin Liu, Wenfei Li, Ling Wu
  • Publication number: 20120136456
    Abstract: A sterile artificial bone product is provided. The sterile artificial bone product comprises a sintered porous ceramic foam material having a density of 0.3 to 1.5 g/cc, and a porosity of 40 to 95%, pores of the material having a pore diameter distribution of 10-500 microns. Additionally, a bioactive compound is coupled to the ceramic foam material. Other embodiments are also described.
    Type: Application
    Filed: November 28, 2011
    Publication date: May 31, 2012
    Inventors: Hadar BETTER, Ricardo OSIROFF, Yossi GROSS
  • Patent number: 8128706
    Abstract: Embodiments described herein are related to pellets that are placed within an extraction site that is in need of bone augmentation and preservation. The pellets are typically cylindrical in shape and comprise a material and a polymer coating. The goal of the pellets are to encourage sufficient new bone growth that jaw bone deterioration is prevented. The pellets create, arrange, and assemble an ideal growth environment for new bone growth to rapidly grow and preserve the original contours of an individual's jaw bone.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: March 6, 2012
    Assignee: Innovative Health Technologies, LLC
    Inventor: Darnell Kaigler, Sr.
  • Patent number: RE43793
    Abstract: Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: November 6, 2012
    Assignees: Universite de Geneve, Ecole Polytechnique Federale de Lausanne
    Inventors: Pierre Descouts, Bjorn-Owe Aronsson, Michael Gratzel, Carine Viorney, Peter Pechy