Including Bioactive Coating Patents (Class 623/23.57)
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Publication number: 20120283839Abstract: A surgical implant device capable of conforming to a variety of surface topographies facilitates the growth and regeneration of site to which the device is applied. The device employs a plurality of elongate members supporting a column of discrete, rotatable elements in contact with each adjacent element. Anchor plates secure the respective ends of the elongate members, such anchor plates attachable to bone. The implant device provides and ordered array of individually rotatable elements to form a surface that permits bodily fluids to pass therethough.Type: ApplicationFiled: July 18, 2012Publication date: November 8, 2012Inventor: Walter E. Strippgen
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Publication number: 20120271418Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.Type: ApplicationFiled: February 28, 2012Publication date: October 25, 2012Applicant: TISSUE REGENERATION SYSTEMS, INC.Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
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Patent number: 8231685Abstract: To improve a cartilage replacement implant for the biological regeneration of a damaged cartilage area of articular cartilage in the human body, comprising a cell carrier which has a defect-contacting surface for placement on the damaged cartilage area and is formed and designed for colonization with human cells, so that after implantation of the cartilage replacement implant, formation of a gap between adjacent contact surfaces of the implant and surrounding recipient tissue is minimized, it is proposed that the cell carrier rest with surface-to-surface contact on a carrier and be joined to the carrier at a cell carrier surface that faces away from the defect-contacting surface. A method for producing a cartilage replacement implant is also proposed.Type: GrantFiled: April 10, 2006Date of Patent: July 31, 2012Assignee: Tetec Tissue Engineering Technologies AGInventors: Juergen Fritz, Christoph Gaissmaier, Wilhelm Karl Aicher
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Patent number: 8215310Abstract: An implant suitable for treatment of treatment of vaginal and/or uterine prolapse and/or pelvic floor reconstruction. The implant comprises a vaginal support member substantially sized or shaped to the portion of the vaginal wall to be supported and at least two extension portions projecting from the support member, wherein at least one extension portion has fixation means for anchoring the extension portion into pelvic paravaginal fibro-fatty issue without being faxed into defined structural tissues. A method of treating treatment of vaginal and/or uterine prolapse and/or pelvic floor reconstruction using the implant is also provided.Type: GrantFiled: April 28, 2011Date of Patent: July 10, 2012Assignee: Coloplast A/SInventor: James Browning
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Patent number: 8206843Abstract: Disclosed are a gradient bioceramic coating comprising a rare earth oxide, a broadband laser method for preparing the bioceramic coating, and the use of the bioceramic coating in the field of medical materials.Type: GrantFiled: October 16, 2008Date of Patent: June 26, 2012Assignee: Guizhou UniversityInventors: Qibin Liu, Wenfei Li, Ling Wu
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Publication number: 20120136456Abstract: A sterile artificial bone product is provided. The sterile artificial bone product comprises a sintered porous ceramic foam material having a density of 0.3 to 1.5 g/cc, and a porosity of 40 to 95%, pores of the material having a pore diameter distribution of 10-500 microns. Additionally, a bioactive compound is coupled to the ceramic foam material. Other embodiments are also described.Type: ApplicationFiled: November 28, 2011Publication date: May 31, 2012Applicant: RAINBOW MEDICAL LTD.Inventors: Hadar BETTER, Ricardo OSIROFF, Yossi GROSS
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Patent number: 8128706Abstract: Embodiments described herein are related to pellets that are placed within an extraction site that is in need of bone augmentation and preservation. The pellets are typically cylindrical in shape and comprise a material and a polymer coating. The goal of the pellets are to encourage sufficient new bone growth that jaw bone deterioration is prevented. The pellets create, arrange, and assemble an ideal growth environment for new bone growth to rapidly grow and preserve the original contours of an individual's jaw bone.Type: GrantFiled: January 8, 2009Date of Patent: March 6, 2012Assignee: Innovative Health Technologies, LLCInventor: Darnell Kaigler, Sr.
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Patent number: 8105391Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: April 1, 2010Date of Patent: January 31, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Publication number: 20120016489Abstract: Implantable pliable bone blocks comprising a solid block of cortical bone characterized by a length, width and thickness, having a first and a second face on opposite sides of the block. The first and second faces have a plurality slot features. The angle of incidence of the slot features of the first face and the x-axis and the angle of incidence of the slot features of the second face and the x-axis (a2) are such that the slots would intersect if they were in the same plane. Methods are provided for making implantable pliable bone blocks.Type: ApplicationFiled: July 16, 2010Publication date: January 19, 2012Applicant: EBI, LLCInventor: Bradford J. COALE
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Patent number: 8067069Abstract: An implantable article including a biocompatible substrate and a bioactive strontium-substituted calcium phosphate ceramic apatite coating chemically bonded to at least a portion of the surface of the biocompatible substrate, wherein the strontium-substituted calcium phosphate ceramic apatite coating includes nanopores, nanocrystals and strontium ions, and includes a hexagonal crystal structure of apatite having a molar ratio of strontium ions to calcium ions of about 0.0001 to about 0.5, and the strontium ions inhibit bone resorption in vitro and enhance bone formation in vivo so that the implantable article exhibits enhance fixation and bone ingrowth in and around the implantable article.Type: GrantFiled: May 4, 2005Date of Patent: November 29, 2011Assignee: DePuy Products, Inc.Inventor: Panjian Li
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Publication number: 20110276148Abstract: An implantable medical device, which comprises a device substrate, a coating on the substrate which includes a drug which is highly soluble in water, and a protective layer which overlies the coating. The protective layer comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid and a lactic acid/glycolic acid copolymer having a weight average molecular weight of not more than 40,000.Type: ApplicationFiled: October 16, 2009Publication date: November 10, 2011Applicant: DEPUY INTERNATIONAL LIMITEDInventors: Yufu Li, Deborah Schachter, Raymond S. Shissias, Sandra Wechsler
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Publication number: 20110213468Abstract: A method of preparing a ceramic-resin composite material for bone repair, including preparing a predetermined amount of pH controlled substantially anhydrous coupling agent by mixing a liquid silane material, alcohol and organic acid, producing particulate bioactive glass having a desired particle size of less than about 53 mesh, measuring a desired quantity of the particulate bioactive glass into a mixing vessel, heating the mixing vessel and particulate bioactive glass to about 100 degrees Celsius, mixing the heated quantity of particulate bioactive glass and spraying a predetermined amount of substantially anhydrous coupling agent into the heated quantity of particulate bioactive glass to define an admixture, mixing the admixture for sufficient time to define a quantity of substantially evenly coated particles, heating the quantity of substantially evenly coated particles for sufficient time to evolve excess solvent therefrom, and incorporating the quantity of substantially evenly coated particles into a rType: ApplicationFiled: February 7, 2009Publication date: September 1, 2011Inventor: Thomas E. Day
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Patent number: 7975698Abstract: An implant suitable for treatment of treatment of vaginal and/or uterine prolapse and/or pelvic floor reconstruction. The implant comprises a vaginal support member substantially sized or shaped to the portion of the vaginal wall to be supported and at least two extension portions projecting from the support member, wherein at least one extension portion has fixation means for anchoring the extension portion into pelvic paravaginal fibro-fatty issue without being faxed into defined structural tissues. A method of treating treatment of vaginal and/or uterine prolapse and/or pelvic floor reconstruction using the implant is also provided.Type: GrantFiled: May 23, 2005Date of Patent: July 12, 2011Assignee: Coloplast A/SInventor: James Browning
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Patent number: 7959682Abstract: In order to provide a bone substitution material which enables mechanical stability and long-term in-vivo biocompatibility which can also be used for guided bone healing, the invention provides a method comprising the steps of providing a starting material comprising a mixture of at least a skeleton substance (20) and at least one functional substance, and building up a skeleton from the skeleton substance, thereby producing a profiled body (30), as well as a profiled body (30) containing a skeleton substance (20) and comprising a porous structure (10) with pores (12, 15) being interconnected with each other.Type: GrantFiled: September 30, 2004Date of Patent: June 14, 2011Assignee: ADC Advanced Dental Care GmbH & Co. KGInventors: Matthias Epple, Drazen Tadic
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Publication number: 20110112654Abstract: One arrangement in combination, a bone implant, and one or more bioactive substances which can reduce inflammation in implant surgery, preferably in the field of dentistry. The implant may also comprise one or more bioactive substance(s) that can promote osseointegration of said bone implant. At least one of said one or more bioactive substances may be capable of reducing proliferation, differentiation, and/or activity of osteoclasts, stimulating proliferation of osteoblasts, and/or reducing inflammation.Type: ApplicationFiled: July 13, 2009Publication date: May 12, 2011Applicant: NOBEL BIOCARE SERVICES AGInventor: Jenny Faldt
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Publication number: 20100331997Abstract: The implant is intended for introduction into an alveolar space. It is configured as an absorbable composite body made of at least a first and a second part body. The first part body is configured as a cone, truncated cone or cylinder having a body base face. The second part body is configured as a cover membrane with a membrane face, which is larger than the body base face. The cover membrane is placed on the body base face, so it projects laterally everywhere over the body base face. The first and second part body are rigidly connected to one another in the region of the mutually adjacent body base face and membrane face.Type: ApplicationFiled: February 9, 2009Publication date: December 30, 2010Inventors: Karl-Heinz Sorg, Claus Martin Hiltner
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Patent number: 7854958Abstract: Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.Type: GrantFiled: March 18, 2009Date of Patent: December 21, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Pamela A. Kramer
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Publication number: 20100249944Abstract: Medical devices having more than one degradation zone or degradation mechanism are used for orthopedic repair devices and soft tissue fixation devices.Type: ApplicationFiled: March 11, 2010Publication date: September 30, 2010Inventors: Jonathan D. Thomas, Joshua Stopek
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Publication number: 20100222892Abstract: A layer applied to a joint defined surface including a general mat shape body exhibiting a plurality of recesses, such that abrading contact with an opposing joint surface creates debris which are entrapped within the recesses during a normal range of motion. The body can further exhibit a first harder plastic substratum and a second softer plastic surface. The recesses further incorporate undercut defined patterns selected from any of circular, linear and arcuate designs.Type: ApplicationFiled: May 10, 2010Publication date: September 2, 2010Applicant: LINARES MEDICAL DEVICES, LLCInventor: Miguel A. Linares
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Patent number: 7772146Abstract: The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration.Type: GrantFiled: August 24, 2004Date of Patent: August 10, 2010Inventor: Kenneth A. McGowan
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Patent number: 7767250Abstract: A process for coating a surface of a metal-containing substrate with a bioceramic material includes activating the surface of the metal-containing substrate by applying a voltage to the substrate in a liquid containing an electrolyte; and, immersing the substrate in a deposition solution containing the bioceramic material or precursors for the bioceramic material. The coated substrate may be heat treated to enhance coating bond strength. The bioceramic material may be hydroxyapatite. Coated substrates are useful for the fabrication of prostheses.Type: GrantFiled: June 15, 2006Date of Patent: August 3, 2010Assignee: National Research Council of CanadaInventors: Benli Luan, Jianhui Xle
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Patent number: 7727540Abstract: Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.Type: GrantFiled: November 19, 2001Date of Patent: June 1, 2010Assignees: Universite de Geneve, Ecole Polytechnique Federale de LausanneInventors: Pierre Descouts, Björn-Owe Aronsson, Michael Grätzel, Carine Viornery, Peter Péchy
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Patent number: 7713637Abstract: Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: March 3, 2006Date of Patent: May 11, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Patent number: 7687098Abstract: A method for fabricating a substitute component for bone, including the processes of: provision of a chemical spray including at least three of calcium chloride, hydrogen phosphate, hydrogen carbonate and water to form a combined solution; reaction and precipitation of the combined solution onto a substrate; allowing the precipitated particles to form a porous structure on the substrate; applying substantially isostatic pressure to the porous structure to form a compressed structure; and (optional) providing one or more through-holes in the compressed structure to promote osteoinduction.Type: GrantFiled: August 26, 2005Date of Patent: March 30, 2010Inventor: Charlie W. Chi
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Patent number: 7670636Abstract: The invention relates to a method for the production of a metallic substrate having a biocompatible surface and to the substrate that is produced by means of said method. The method comprises treatment of a metal, i.e., Ti, Ti alloys with Al, V, Ta, Nb, Ni, Fe, Mo or mixtures thereof, Ta, Ta alloys with Fe, Al, Cr, stainless steel, with a melt of calcium nitrate and an additional component which is an oxygen salt of Na, K, Li, Mg and mixtures thereof, said treatment being effected at 180-480 ° C. for 0.1 to 12 hours. A substrate is obtained, wherein the overall layer thickness ranges from 10 to below 1600 nm and the fatigue strength of the substrate is in the same fatigue strength range as that of an untreated substrate at equal number of vibrations N.Type: GrantFiled: November 28, 2006Date of Patent: March 2, 2010Assignee: BAM Bundesanstalt fuer Materialforschung und -pruefungInventors: Georg Berger, Ute Ploska
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Patent number: 7645504Abstract: Coatings for implantable medical devices and methods for fabricating thereof are disclosed. The coatings include a layer comprising a hydrophobic polymer and a layer comprising a hydrophilic or amphiphilic polymer.Type: GrantFiled: June 26, 2003Date of Patent: January 12, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Stephen D. Pacetti
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Publication number: 20090319051Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.Type: ApplicationFiled: July 31, 2008Publication date: December 24, 2009Inventors: Jeffrey H. Nycz, Keith M. Kinnane, Susan J. Drapeau, Daniel A. Shimko, Jeetendra S. Bharadwaj
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Publication number: 20090276053Abstract: An implantable device which provides structural support for the skeletal system, such as the spine, coated with hydroxyapatite (HA). This invention provides a mechanically and bioactively functional coating of hydroxyapatite (HA) without altering the biocompatibility profile of the poly-ether-ether-ketone (PEEK) substrate.Type: ApplicationFiled: April 22, 2009Publication date: November 5, 2009Inventors: Timothy Brown, Qi-Bin Bao
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Patent number: 7563483Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include hydrophilic and hydrophobic components. The methods provide for treatment of the coatings to cause enrichment a region close to, at or on the outer surface of the coating with the hydrophilic component.Type: GrantFiled: February 22, 2005Date of Patent: July 21, 2009Assignee: Advanced Cardiovascular Systems Inc.Inventors: Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Stephen D. Pacetti
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Publication number: 20090093881Abstract: The present disclosure is directed to modified metal materials for implantation and/or bone replacement, and to methods for modifying surface properties of metal substrates for enhancing cellular adhesion (tissue integration) and providing antimicrobial properties. Some embodiments comprise surface coatings for metal implants, such as titanium-based materials, using (1) electrochemical processing and/or oxidation methods, and/or (2) laser processing, in order to enhance bone cell-materials interactions and achieve improved antimicrobial properties. One embodiment comprises the modification of a metal surface by growth of in situ nanotubes via anodization, followed by electrodeposition of silver on the nanotubes. Other embodiments include the use of LENSâ„¢ processing to coat a metal surface with calcium-based bioceramic composition layers. These surface treatment methods can be applied as a post-processing operation to metallic implants such as hip, knee and spinal devices as well as screws, pins and plates.Type: ApplicationFiled: October 6, 2008Publication date: April 9, 2009Applicant: Washington State UniversityInventors: Amit Bandyopadhyay, Susmita Bose
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Publication number: 20090088844Abstract: A medical implant device includes a prosthesis adapted to replace at least a portion of a bone. The prosthesis includes a drug-eluting polymer adapted to deliver a drug to at least a portion of an area surrounding the prosthesis.Type: ApplicationFiled: June 30, 2008Publication date: April 2, 2009Inventors: Mark E. Keegan, Michael J. McKenna
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Publication number: 20090054983Abstract: The invention relates to an artificial bone implant for preservation, repair, and regeneration of the human musculoskeletal apparatus by means of orthopedic, dental and craniofacial implantation. More in particular, the invention relates to use of osteoinductive compositions comprising stem cells from adipose tissue and osteoconductive calcium phosphates in bioresorbable cages as part of an artificial bone implant for stabilization and renewed alignment of spinal column segments.Type: ApplicationFiled: July 25, 2005Publication date: February 26, 2009Applicant: TECHNOLOGIESTICHTING STWInventors: Paulus Ignatius J.M. Wuisman, Martinus Nicolaas Helder
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Publication number: 20080306608Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.Type: ApplicationFiled: July 31, 2008Publication date: December 11, 2008Inventors: Jeffrey H. Nycz, Keith M. Kinnane, Susan J. Drapeau, Daniel A. Shimko, Jeetendra S. Bharadwaj
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Patent number: 7445641Abstract: The present invention relates to biomaterials modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. This modification may be by covalent conjugation, copolymerization, or admixture of the non-proteinaceous catalysts with the biomaterial. The resulting modified biomaterials exhibit a marked decrease in inflammatory response and subsequent degradation when placed in contact with vertebrate biological systems.Type: GrantFiled: May 26, 2000Date of Patent: November 4, 2008Assignee: Pharmacia CorporationInventors: Richard Ornberg, Kishore Udipi, Denis Forster, Dennis Riley, Bruce Thurmond, Susan Henke, Kerry Brethauer
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Publication number: 20080255676Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.Type: ApplicationFiled: January 24, 2007Publication date: October 16, 2008Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
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Publication number: 20080255677Abstract: A surface coating comprises a primer coat that permits adhesion of eukaryotic cells thereto, and a plurality of macromolecular structures attached to the primer coat. At least some of the macromolecular structures have a cell-resistant character, meaning that cells generally will not adhere to them. The macromolecular structures are distributed across an area of the primer coat so that the surface coating permits adhesion of the eukaryotic cells to the primer layer and resists the adhesion of non-eukaryotic cells. Typically, the primer coat comprises a self-assembled polymeric monolayer and the macromolecular structures comprise nanoscale hydrogels. Such surface coatings may be formed on articles of manufacture for insertion into the body, such as orthopedic devices.Type: ApplicationFiled: April 8, 2008Publication date: October 16, 2008Inventor: Matthew R. Libera
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Patent number: 7427293Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.Type: GrantFiled: March 28, 2006Date of Patent: September 23, 2008Assignee: SDGI Holdings, Inc.Inventors: Jeffrey H Nycz, Keith M Kinnane, Susan J Drapeau, Daniel A Shimko, Jeetendra S Bharadwaj
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Patent number: 7413806Abstract: Implants may be coated with a biocompatible coating to improve the biocompatibility of the implant. The biocompatible coating may include a bone growth promoting compound. Such compounds include, but are not limited to, phospholipids, bone morphogenetic proteins, or combinations thereof. The bone growth promoting compound may enhance the rate of bone growth proximate to the implant and the integration of the implant into the surrounding bone.Type: GrantFiled: December 17, 2002Date of Patent: August 19, 2008Assignee: Board of Regents, The University of Texas SystemInventors: Joo L. Ong, Rajiv K. Satsangi, Neera Satsangi
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Patent number: 7410502Abstract: The invention relates to a medical prosthetic device having a metal material, such as titanium or an alloy thereof, where the surface parts of the metal material are coated with a layer of a corresponding hydroxide material, such as titanium hydroxide. Preferably, the hydroxide layer includes one or more biomolecule substances associated therewith. The invention also relates to an electrolytic process for the preparation of a medical prosthetic device.Type: GrantFiled: April 9, 2003Date of Patent: August 12, 2008Assignee: Numat ASInventors: Jan Eirik Ellingsen, Staale Petter Lyngstadaas
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Publication number: 20080125868Abstract: An implant and an implant member for attaching to living biological tissue of a human being or an animal. The implant has an outer surface comprising a first part and a second part which have different properties with regard to the biocompatibility of each part with biological tissue. The implant includes at least one surface portion comprising a ground surface making up the first part and one or several delimited regions making up said second part. A method for producing the implant, where a perforated masking unit is applied onto the implant, and a masking unit for the method.Type: ApplicationFiled: December 12, 2005Publication date: May 29, 2008Inventors: Rickard Branemark, Peter Thomsen
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Patent number: 7377943Abstract: The invention relates to a metallic implant, which has vitreous-crystalline bioactive material on the surface thereof. According to the invention, a metallic implant base body arranged on the surface of the particles has a bioactive, vitreous-crystalline material consisting of 15-45 wt. % CaO, 40-45 wt. % P2O5, 10-40 wt. % ZrO2 and 0.7-3.5 wt. % fluoride, having apatite and calcium zirconium phosphate as main crystalline and a glass phase as an auxiliary component. Said vitreous crystalline material contains at least 35 wt. % main crystal phases and at least 5-15 wt. % auxiliary compounds. All of the percentage data is expressed in relation to the total weight of the vitreous crystalline material and the particle size of the vitreous crystalline material is between 60-350 ?m.Type: GrantFiled: June 14, 2002Date of Patent: May 27, 2008Assignees: Humboldt-Universitaet Berlin, Charite Universitaetsklinikum, BAM Bundesanstalt fuer Materialforschung und - pruefungInventors: Wolf-Dieter Müller, Georg Berger
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Publication number: 20080071382Abstract: A method of forming a bioactive coating on a biomedical implant, the method including the step of contacting at least part of the surface of the implant prior to implantation with a plasma gas containing a reactive hydroxylating oxidant species. The step of contacting the surface of the implant prior to implantation with a plasma gas containing a reactive hydroxylating oxidant species may be preceded by a step of exposing the implant to an organosilane or organosilicate species to form a silica coating on at least part of the implant prior to contact with the oxidant species.Type: ApplicationFiled: January 19, 2005Publication date: March 20, 2008Applicant: University of South AustraliaInventors: Sunil Kumar, Hailong Zhang, Darren John Simpson, Roger St. Clair Smart
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Patent number: 7247364Abstract: An implantable medical device, such as a stent, is disclosed having a coating. The coating includes a poly(butylene terephthalate-co-ethylene glycol)polymer. The coating can also include a drug.Type: GrantFiled: February 25, 2005Date of Patent: July 24, 2007Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Stephen D. Pacetti
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Patent number: 7192445Abstract: Disclosed are medical prosthetic devices or medical implants which exhibit improved biocompatitibly. The devices or implants include a metal material, e.g. titanium, in which the metal surface parts are coated with a corresponding hydride material that contains one or more biomolecule substance. This biomolecule substance may contain one or more biologically active molecules, e.g. bio-adhesives, biopolymers, blood proteins, enzymes, extra cellular matrix proteins, extra cellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, enzyme inhibitors, drugs, biologically active anions and cations, vitamins, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), marker biomuolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.Type: GrantFiled: December 6, 2001Date of Patent: March 20, 2007Assignee: Astra Tech ABInventors: Jan Eirik Ellingsen, Staale Petter Lyngstadaas
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Patent number: 7163920Abstract: The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.Type: GrantFiled: September 30, 2003Date of Patent: January 16, 2007Assignee: Ethicon, Inc.Inventors: Sridevi Dhanaraj, Anna Gosiewska, Ali Rezania, George A. Heavner, Xuanhan Lin, Chin-Feng Yi
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Patent number: 7087086Abstract: The invention provides an implantable article, a method of preparing the same, and methods of modifying a ceramic-coated implantable article. The implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon with a composition comprising (i) a biological agent, (ii) calcium ions, (iii) phosphate ions, and (iv) a liquid carrier.Type: GrantFiled: January 31, 2003Date of Patent: August 8, 2006Assignee: Depuy Products, Inc.Inventors: Panjian Li, Hai Bo Wen, Elizabeth A. Hippensteel
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Patent number: 7063884Abstract: A stent comprising a coating layer is disclosed. The coating layer has a hydrophobic component and a hydrophilic component, wherein a region of the coating layer on or about the outermost surface of the coating layer has a higher content or concentration of the hydrophilic component than the hydrophobic component.Type: GrantFiled: February 22, 2005Date of Patent: June 20, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Stephen D. Pacetti
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Patent number: 7018411Abstract: A bone replacement endoprosthesis has a metallic support structure, at least part of the surface of which is galvanically silvered. Beneath the silver layer a bond layer is provided which can comprise gold.Type: GrantFiled: February 18, 2002Date of Patent: March 28, 2006Assignee: Implantcast GmbHInventors: Georg Gosheger, Jens Sass
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Patent number: RE40816Abstract: A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle ? between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device. The present invention provides a biocompatible crosslinked coating and a crosslinkable coating polymer composition for forming such a coating.Type: GrantFiled: November 1, 1996Date of Patent: June 30, 2009Assignee: Biocompatibles UK LimitedInventors: Alistair Stewart Taylor, Peter William Stratford, Yiannakis Petrou Yianni, Matthew John Woodroffe, Lee Rowan
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Patent number: RE43793Abstract: Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.Type: GrantFiled: November 19, 2001Date of Patent: November 6, 2012Assignees: Universite de Geneve, Ecole Polytechnique Federale de LausanneInventors: Pierre Descouts, Bjorn-Owe Aronsson, Michael Gratzel, Carine Viorney, Peter Pechy