Abstract: Disclosed is a system and method for directing data representing well operations (drilling and producing) through the Internet or similar wide area network. The instant invention comprises a system and method of installing sensors at the well to provide technical information to remotely-located Internet users who provide services to the well owner. The service providers may be observers, who may then advise the well owners and operators as to actions to take to increase or optimize well performance. Service providers may also be data storage companies, who clean and store the data from the well. Service providers may then be paid from a portion of the well revenues or a portion of the incrementally-increased revenues.

Abstract: A method and apparatus suitable for monitoring the quality and/or performance of a processing aid or a component during manufacture, storage, or use of electronics or electronic assemblies is provided. The apparatus incorporates a sampling device, a multivariate sensing system (e.g., a multi-sensor array or at least one sensor capable of measuring multiple variables) capable to process an analysis of low vapor pressure or vaporizable constituents in electronics by detecting some changes in the physico-chemical properties of the sensor and/or electronics and applying multivariate analysis. In one embodiment, the sensing system comprises an array of metal oxide sensors and a multivariate analysis algorithm for data processing. This method and apparatus can be employed for various quality control purposes such as contamination analysis or failure analysis of integrated circuits components.

Abstract: Apparatus and a method are described for investigating polymorphs of a material, isomers of a material which allow different isomeric forms to be resolved, different hydrates/solvates and/or different salts of a material. The apparatus comprises an assembly (2) of reactor devices (6) arranged within a reactor body (8) which incorporates a heating/cooling block (10) and a stirrer block (12). A vessel support block (14) supports respective sample vessels (15) below each reactor device (6) for recieving material from the reactor devices. The apparatus includes a control unit (4) which includes a computer (16) which controls a robot for delivering materials to the reactor devices; a heating/cooling unit (18); a stirrer control unit (20); and a pressure unit (22) which controls the passage of material from the reactor devices (6) to the sample vessels (15).

Abstract: A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies the corresponding sequence if it is present in the database, without the need for a skilled observer to choose from amongst a list of possible matches. By using an automated back-read process, the present method can uniquely identify a corresponding peptide sequence in a database based on a single matching peptide sequence. The method also permits mapping of mass spectral data to sequences in peptide or nucleotide databases for unambiguous identification of exons; determining a correct reading frame; identifying artefacts and errors in sequences; identifying mutations and polymorphisms; identifying post-translational modifications; and identifying exon-intron boundaries.

Abstract: A database interpolation method is used to rapidly calculate a predicted optical response characteristic of a diffractive microstructure as part of a real-time optical measurement process. The interpolated optical response is a continuous and (in a preferred embodiment) smooth function of measurement parameters, and it matches the theoretically-calculated optical response at the database-stored interpolation points.

Abstract: A reduced multicubic database interpolation method is provided. The interpolation method is designed to map a function and its associated argument into an interpolated value using a database of points. The database is searched to locate an interpolation cell that includes the function argument. The interpolation cell is used to transform the function argument to reflect translation of the interpolation cell to a unit cell. The interpolated value is then generated as a cubic function using the data points that correspond to vertices of the unit cell. All of the derivatives in the cubic function are simple and the interpolation accuracy order is higher than first-order.

Abstract: The present invention provides a method and system for management of chemical materials comprising the steps of providing a first data set containing which substances comprise the materials, providing a second data set containing which of the substances are to be controlled, providing a third data set containing a ratio of discharge of the controlled substances in a process, analyzing a preset amount of the materials in the process and determining a quantity of the controlled substances utilizing the first and second data sets, determining an emissions quantity of the controlled substances utilizing the ratio and the quantity of the controlled substances and maintaining the third data set according to a preset interval of time.

Abstract: A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample.

Abstract: An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.

Abstract: A method for chemical analysis of fluids utilized in hydrocarbon exploration and production in which microfluidic systems designed to react to specific characteristics of a fluid are introduced into fluid samples or during operations. The microfluidic systems are then recovered and subjected to analysis to permit one to measure the desired characteristics.

Abstract: A method and apparatus for analyzing a fluid to obtain the concentrations of N of its components, N being at least three. The method comprises the steps of bringing a sample of the fluid to a plurality of successive temperatures, measuring a combined total of at least N acoustical and electrical parameters of the sample at each temperature, and determining simultaneously from the measured acoustical and electrical parameters, using a system of N linear equations, the concentrations of the N components. The apparatus combines acoustic and electrical measuring elements in one unit.

Abstract: A method and system for predicting the content level of components in materials based on the response of the materials to near infrared radiation. One embodiment comprises electronically receiving a near infrared reflectance spectrum of a material from a customer, predicting the content level of a component in the material based on the spectrum, and electronically reporting the prediction to the customer. Another embodiment includes the exchange of the customer request and prediction report on a Web site or by electronic mail. Other embodiments include the prediction reports, and uses of the predictions, for example in quality control and toxicity evaluation.

Abstract: A main object is to cope with an unknown structure substance thereby to identify the structure of a parent ion highly precisely and to derive a supposed structure. A method for analyzing mass spectrometric data is disclosed, which: acquires mass spectrometric data on an ionized sample and dissociated ions dissociated from the sample as a parent ion; derives dissociated ion candidates by analyzing the molecular orbits on the candidates of the structures of the parent ion; and displays the analytical results of the parent ion candidates and the dissociated ion candidates and compares the data of the dissociated ion candidates and the data of dissociated ions actually measured, to evaluate the structures of the parent ion candidates.

Abstract: The present invention features mass spectrometry data analysis techniques that can be employed to selectively identify analytes differing in abundance between different sample sets. The employed techniques determine the statistical significance of changes to signals associated with mass-to-charge ratios (“m/z-intensity pairs”) between individual samples and sample sets. Based on the statistical significance, changes likely to indicate analyte level differences are identified. Based on intensities of the signals, ratios of analyte abundances can be determined.

Abstract: A synthetic gas generator and gas reactor test system. The system is configurable to provide a number of alternative flow paths, each with different furnace and reactor configurations. Various types of reactors, and combinations of two or three reactors, may be installed and tested. Injected agents, such as reducing agents, are injected in a manner that prevents unwanted reactions with the test gas. The system is especially useful for testing vehicle emissions aftertreatment devices.

Abstract: A mass spectrometer and associated methods analyze an ion beam by accumulating ions for a sequence of time periods, and driving the accumulated ions in pulses. Differing quantities of ions can be accumulated in the sequential pulses according to a psuedo-random sequence, and the slower ions are overtaken by the faster ions of a subsequent pulse. A mass spectrum may be reconstructed from an overlapping ion detector signal using an inverse of a weighted simplex matrix or inverse Hadamard transform techniques.

Abstract: A method is provided for measuring by ionization mobility spectrometry (IMS) relatively high concentrations of water in argon, hydrogen, nitrogen and/or helium, including the following steps: (a) introducing the gas to be analyzed into an IMS instrument with a counter-flow of pure gas; (b) obtaining a signal variable over time and proportional to the number of ions detected by an ion detector of the IMS instrument; (c) determining two time intervals (A, B) corresponding to the drift times in the IMS instrument of the H3O+ and (H2O)2+ ions; (d) obtaining the peaks of the signal in the two determined time intervals (A, B); and (e) calculating the water concentration in the gas to be analyzed according to the ratio between the intensity of the two peaks obtained in the signal.

Abstract: A fully-automated method for segmentation of white matter, gray matter, and cerebral spinal fluid (CSF) and for calculating their respective volumes is disclosed. The technique preferably uses a T2-weighted scan and a proton-density scan. The T2-weighted scans are used to highlight those portion of the brain corresponding to CSF. Thereafter, the proton density images are separated in CSF-containing and CSF-free portions, in accordance with the T2-weighted images. The CSF-free portion is then segmented into white matter and gray matter portions. The CSF-containing portion is further segmented into pure CSF-regions, and regions containing a mixture of gray and white matter and CSF. After CSF is segmented from this mixture, the white and gray matter and again segmented, and the respective volumes of white matter, gray matter, and CSF are calculated.

Abstract: A liquid-suspended particle analyzer includes: a fine liquid droplet producing device for atomizing a liquid pumped from a sample container by a fixed-displacement pump to produce fine liquid droplets suspended in a carrier gas; an evaporator for evaporating the liquid parts of the fine liquid droplets to produce an aerosol of the carrier gas and particles suspended in the carrier gas; a differential mobility classifier for classifying the particles of the aerosol by particle size according to mobility; and a Faraday cup electrometer for counting the respective numbers of the particles of the particle groups classified by particle size by the differential mobility classifier so as to determine the respective particle concentrations of the groups.

Abstract: The invention is a method and a device for measuring the filtering or purifying capacity of a purifier. The invention allows the use of a single analyzer for sampling the inlet and outlet streams. This is accomplished by sampling the inlet stream only at some times when the change in the inlet stream is expected to occur. At other times the outlet stream is sampled to monitor its composition. A computer system on the basis of the accumulated data decides when it is time to replace or to regenerate the purifier or the filter bed. The computer system also determines the strategy of when to sample the inlet stream. Various system sensors may be used to make this determination, such as pressure sensors and level sensors. The data from other sensors, such as flow sensors, may be used in the calculations performed by the computer system.

Abstract: A fourth embodiment of the present invention is a method of generating a temperature compensated absorbance spectrum. The method includes the steps of: a. providing a sample spectrum and an estimated temperature of a backdrop object; b. from a set of known temperature spectra related to a known background temperature, selecting at least two known temperature spectra representing a background temperature above and below the estimated temperature; c. comparing the sample spectrum to the known temperature spectra in order to determine a sample background spectrum; and d. calculating an absorbance spectrum from the sample spectrum and the background spectrum.

Abstract: Described herein are methods, devices, and microprocessors useful for predicting a hypoglycemic event in a subject. The hypoglycemic predictive approach described herein utilizes information obtained from a data stream, e.g., frequently obtained glucose values (current and/or predicted), body temperature, and/or skin conductance, to predict incipient hypoglycemic events and to alert the user.

Abstract: A chemical detection system performs controlled exposures to diagnose the pneumatic components and chemical sensors prior to measuring a chemical emission. A control module provides the system control and data processing to perform the diagnosis. The control module manipulates an emission sample retrieval system to provide precise exposure during the diagnostic routines. A sensor interface circuit interrogates the chemical sensors and stores the data for analysis. The chemical sensor exhibits predictable changes in response during predetermined exposure scenarios. By utilizing numerous time domain signal processing techniques, both system and sensor level fault conditions are determined.

Abstract: The invention relates to the analysis of interactions of substances or materials with surfaces or interfaces made from amphiphilic materials and in particular partition coefficients and/or binding constants are determined. For this purpose use is made of a carrier material, which is so coated with amphiphilic molecules in the so-called fluid phase that the lateral diffusion of the amphiphilic molecules is substantially unimpeded. The invention also relates to a kit suitable for such analyses, and to a process for analyzing these interactions in column chromatography, particularly high pressure or performance liquid chromatography.

Abstract: A method and apparatus is provided for detecting an impurity in a sample where an index can be calculated to assess purity in the presence of n major components with signal averaging or noise-filtering automatically built-in. The method and apparatus can be applied to liquid chromatography impurity detection using UV-VIS spectrophotometry based on robust matrix algebra representing the entire spectral space generated by the sample.

Abstract: A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

Abstract: Methods, apparatus, media and signals for identifying associated cell signaling proteins are disclosed. The method involves producing and storing a comparison value for each pair of the cell signaling proteins in response to data values representing physical properties of respective cell signaling proteins. The method further involves identifying cell signaling protein pairs having comparison values satisfying a condition indicative of an association between the cell signaling proteins.

Abstract: The invention provides a method and an arrangement for filtering or pre-processing most any type of multivariate data exemplified by NIR or NMR spectra measured on samples in order to remove systematic noise such as base-line variation and multiplicative scatter effects. This is accomplished by differentiating the spectra to first or second derivatives, by Multiplicative Signal Correction (MSC), or by similar filtering methods. The pre-processing may, however, also remove information from the spectra, as well as other multiple measurement arrays, regarding (Y) (the response variables). Provided is a variant of PLS that can be used to achieve a signal correction that is as close to orthogonal as possible to a given (y) vector or (Y) matrix. Hence, ensuring that the signal correction removes as little information as possible regarding (Y). A filter according to the present invention is named Orthogonal Partial Least Squares (OPLS).

Abstract: A diffusion status prediction method and system for a diffused substance are disclosed. The diffused substance is replaced by particles, and positions which the particles generated from an emission source arrive at are found by computation. The arrival positions and a post-emission elapsed time are recorded in association with each other. Also, intensity data showing the intensities of the particles during the passage of the post-emission elapsed time are set. Then, the intensity of the particles at the point in time at which the particles were generated is found by reference to the intensity data based on the post-emission elapsed time. For each particle, the arrival position, the post-emission elapsed time, and the intensity are recorded in association with each other. The concentration of the diffused substance in a predetermined area after a lapse of a predetermined time can be determined by adding up the intensities of the particles present in the predetermined area.

Abstract: A computer product for determining thermodynamic properties of a natural gas hydrocarbon, when the speed of sound in the gas is known at an arbitrary temperature and pressure. Thus, the known parameters are the sound speed, temperature, pressure, and concentrations of any dilute components of the gas. The method uses a set of reference gases and their calculated density and speed of sound values to estimate the density of the subject gas. Additional calculations can be made to estimate the molecular weight of the subject gas, which can then be used as the basis for mass flow calculations, to determine the speed of sound at standard pressure and temperature, and to determine various thermophysical characteristics of the gas.

Abstract: Methods and apparatuses for determining entrained and/or dissolved gas content of gas-liquid mixtures. Data generated is used to control the True (air-free) or Apparent (air-containing) Density or Entrained Air content of liquids within optimum ranges, e.g. in paper coating processes and in the manufacture of food products, personal care products, pharmaceutical products, paints, petroleum blends, etc.

Abstract: Devices for cost-effectively performing in-vitro diagnostic chemical analyses at multiple distributed locations within a medical institution are disclosed. One object of this invention is to provide a network of distributed sensory devices that acquire sensor signals from blood specimens and deliver those signals through a connect on to a central location for analysis by a general-purpose computer and generation of an analysis result. The analysis result is then sent to numerous locations on a network for display, including also possibly back to the location of signal acquisition. Cost-effective mobile sensing devices are also disclosed. The present system includes blood-sensor signal acquisition devices distributed throughout the hospital. The sensory signal-acquisition devices are card readers that acquire raw sensory signals from diagnostic cards inserted therein.

Abstract: The present invention provides a distributed sensing system in a networked environment for identifying an analyte, including a first sensor array connected to the network comprising sensors capable of producing a first response in the presence of a chemical stimulus; a second sensor array connected to the network comprising sensors capable of producing a second response in the presence of a physical stimulus; and a computer comprising a resident algorithm. The algorithm indicates or selects the most relevant sensor in the network to identify the analyte. The sensors can be separated over large spatial areas, wherein the sensor arrays are networked. Suitable networks include a computer local area network, an intranet or the Internet.

Abstract: An exhaust emission control system for an internal combustion engine is disclosed. The system includes a NOx removing device provided in an exhaust system of the engine for removing NOx contained in exhaust gases, and an oxygen concentration sensor provided in the exhaust system. The air-fuel ratio of the air-fuel mixture to be supplied to the engine is changed from a value which is leaner than the stoichiometric ratio to a value which is richer than the stoichiometric ratio. It is determined whether or not a sulfur oxide concentration in the exhaust gases is high according to a transient characteristic of an oxygen concentration detected by the oxygen concentration sensor after the air-fuel ratio is changed.

Abstract: Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Additionally, the series of bands for multiple samples can be aligned on the display device.

Abstract: The invention is a method and a device for measuring the filtering or purifying capacity of a purifier. The invention allows the use of a single analyzer for sampling the inlet and outlet streams. This is accomplished by sampling the inlet stream only at some times when the change in the inlet stream is expected to occur. At other times the outlet stream is sampled to monitor its composition. A computer system on the basis of the accumulated data decides when it is time to replace or to regenerate the purifier or the filter bed. The computer system also determines the strategy of when to sample the inlet stream. Various system sensors may be used to make this determination, such as pressure sensors and level sensors. The data from other sensors, such as flow sensors, may be used in the calculations performed by the computer system.

Abstract: The invention relates to a method and an apparatus for the on-line analysis of liquid substance mixtures by means of NIRS. For evaluation by spectral data comparison, merely the binary mixtures of the possible components in quantitative graduations are used as calibration spectra. In order to accelerate the evaluation, all data points of a spectrum are summated, and each spectrum is characterized by only one characteristic number.

Abstract: The method and the apparatus for determining the mass of portioned units of active substances, in particular capsules, tablets or dragees, comprises leading the units of active substances through a microwave resonator and determining the mass from the displacement of the resonant frequency and the broadening of the resonance curve.

Abstract: An optimum method for deposition time is provided that can improve uniformity of processing time of oxidation thickness. When starting a heat oxidation process, a time for optimum oxidation processing in the process management system is calculated based on atmospheric pressure data, a target thickness of that process, oxidization time, thickness data and atmospheric pressure data in the immediately preceding process under the same oxidization processing job. The optimum system comprises a process management system such as a host computer, a device having a barometer, a heat oxidation-processing device and a thickness-measuring device. The host computer, the barometer, the heat oxidation processing device and the thickness-measuring device are connected via a network so as to transmit data to and from each device.

Abstract: Techniques for analyzing gene expression levels are provided. In one aspect of the invention, the technique provides a method for determining a concentration level of a target nucleic acid, the target nucleic acid comprising at least one target oligonucleotide. The method determines (i) a measure of affinity value of the target oligonucleotide with a probe oligonucleotide; and (ii) a hybridization intensity value for the target oligonucleotide and the probe oligonucleotide at a probe spot. The measure of affinity value and the hybridization intensity value are used to determine the concentration level of the target nucleic acid.

Abstract: A method for specifying a multi-component composition without human intervention includes customer specification of at least two physical property limitations, and determination of a recommended composition meeting those limitations using a continuous model relating the physical properties to the compositional variables. The method may extend to supplying a multi-component composition by further including one or more of calculating the cost of the recommended composition, calculating the price of the recommended composition, formulating a contracted amount of the recommended composition, and billing for a contracted amount of the recommended composition.

Abstract: The present invention provides a method for calculating the resolution of blood glucose which corresponding with the peak value of the rising curve. The average peak value is obtained from calculating the plurality of peak value, which determined after the pre-setting sampling time. Then, the average peak value is calculated with the resistance of the measuring circuit, reference resistance, and reference voltage to obtain the resolution of the blood glucose. Furthermore, the mapping table can be fabricated by the different height of maximum peak value and outputted voltage in different presetting sampling time, such that the resolution of blood glucose can be obtained in different outputted voltage values.

Abstract: The present invention mainly relates to a method and apparatus for measuring the concentration of a solute in a solvent. Disclosed is an apparatus or method for determining the concentration of a solute in a solvent of a solution in a container having a time-varying volume by analyzing two signals received from the solution, comprising: measuring the quantity of the two received signals, converting the two signals into two electro-optical or electrical signals, performing a mathematical transformation on the two electro-optical or electrical signals, and determining the ratio of the transformation components of the two electro-optical or electrical signals. The present invention can be used in various applications of determining the ingredient concentration of a fluid, such as a gas or liquid. Particularly, the present invention finds applications in blood analysis in a human body for measuring, for example, the glucose, triglycerol, cholesterol, or oxyhemoglobin concentrations of the blood.

Abstract: An automated modeler for modeling of an interactive system comprising at least one biological entity and at least one pharmaceutical substance, the system comprising, a representation of states of said system, a knowledge tree builder, associated with said representation for allowing users to define the states, expected relationships between said states and independent inputs to the states, and a data miner associated with said representation to operate on data taken from said system to apply said data to said states in accordance with said defined relationships and inputs, thereby to apply numerical values to said relationships and said inputs, thereby to model said interactions.

Abstract: The present invention features mass spectrometry data analysis techniques that can be employed to selectively identify analytes differing in abundance between different sample sets. The employed techniques determine the statistical significance of changes to signals associated with mass-to-charge ratios (“m/z-intensity pairs”) between individual samples and sample sets. Based on the statistical significance, changes likely to indicate analyte level differences are identified. Based on intensities of the signals, ratios of analyte abundances can be determined.

Abstract: Methods and systems for continuously transferring balancing mass to a rotating system or rotating device in order to dynamically balance the rotating system or rotating device are disclosed. A flow of balancing mass can be continuously provided to the rotating system at a controlled flow rate. A pump integrated with the rotating system can be utilized to provide via pump the flow of the balancing mass to the rotating system at a controlled flow rate. The flow of balancing mass can be thereafter discharged at a shutter device integrated with the rotating system, such that the balancing mass passes through a window of the shutter device if the window is open. The balancing mass is passed through the window so as to be transferred to the rotating device at predetermined locations, thereby contributing to the balancing of the rotating system. The balancing mass is generally automatically recirculated through the rotating system if the window of the shutter device is closed.

Abstract: Disclosed is a method for detecting and quantifying clustered damages in DNA. In this method, a first aliquot of the DNA to be tested for clustered damages with one or more lesion-specific cleaving reagents under conditions appropriate for cleavage of the DNA to produce single-strand nicks in the DNA at sites of damage lesions. The number average molecular length (Ln) of double stranded DNA is then quantitatively determined for the treated DNA. The number average molecular length (Ln) of double stranded DNA is also quantitatively determined for a second, untreated aliquot of the DNA. The frequency of clustered damages (&PHgr;c) in the DNA is then calculated.

Abstract: A method and system for measuring hydrocarbon content in a gas sample measures individual hydrocarbon concentrations in the gas sample and determines a total concentration based on the individual concentrations. The total concentration is validated and/or scaled by determining whether water interference may be occurring and either adjusting the total concentration or flagging the total concentration as invalid. The total concentration may also be adjusted to account for ambient conditions, such as temperature, pressure or relative humidity, as well as for potential double-counting of individual hydrocarbon species.

Abstract: A process tool controller of a semiconductor processing tool is provided with software that enables collecting, monitoring and logging information regarding the tool's consumption. Data is collected from the devices used for control of process conditions via the analog and digital inputs and outputs of the process tool controller. Consequently, the devices for controlling the process conditions have the additional function of measuring the tool's consumption. In this way the information regarding the tool's consumption is completely collected on board of the process tool. The parameters to be monitored and reported can be configured by the user, with use of a configuration editor, resulting in optimum flexibility of the system. In the illustrated embodiment, the user interface of the consumption monitoring and logging software is integrated into the user interface of the process control and monitoring software.

Abstract: The present invention relates to a method and system for managing data. The invention is intended to provide a data managing method and data managing system capable of classifying created files and managing them without depending on the operator's ability. The method is for use in an analytical instrument having a function of imaging a specimen and a function of analyzing the specimen. The area of the specimen from which the image has been taken is analyzed totally or partially. The analytical instrument includes an analytical data managing unit for recording the resulting data hierarchically in a corresponding manner to the specimen area.