Quantitative Determination (e.g., Mass, Concentration, Density) Patents (Class 702/23)
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Patent number: 7391017Abstract: The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption. Always slightly distorted mass scales of different mass spectra from the same type of sample can be aligned. The flight times of identical ions always differ slightly from one mass spectrum to the next due to non-reproducible processes in the ionization method. Thus the apparent mass values of ion signals of identical substances in different mass spectra do not match even if the flight times are converted into mass values with the identical calibration equation. After alignment of the mass scales, mass spectra can be reliably compared with respect to deviations in intensities of bio-makers, or be added together without deterioration in the mass resolution, and improved reference spectrum libraries can be created. Furthermore, the invention allows more reliable library searches to be carried out.Type: GrantFiled: October 12, 2005Date of Patent: June 24, 2008Assignee: Bruker Daltonik, GmbHInventors: Markus Kostrzewa, Stefan Klepel, Thomas Maier
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Publication number: 20080147332Abstract: There are many inventions described and illustrated herein. In one aspect, the inventions relate to a system and method to monitor, control, manage and/or measure the delivery of one or more fluids (for example, liquid, gas and/or gas vapor forms of oxygen, nitrogen, carbon dioxide, hydrogen, and/or propane) from a fluid storage unit (whether mobile (for example, portable and/or transportable between a plurality of locations) or immobile (for example, permanently or semi-permanently fixed in a predetermined location)). In another aspect, the present inventions relate to a system and method to fill, refill, distribute, allocate and/or dispense fluid to one or more such fluid storage units (which contain or are capable of containing one or more such fluids).Type: ApplicationFiled: December 13, 2007Publication date: June 19, 2008Inventor: Muralidharan P. Arikara
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Publication number: 20080133146Abstract: A test device (10) for determining the analyte concentration in a current sample. A measuring unit (28) is included in the test device and is adapted to measure the reaction of a reagent and the analyte and to generate a signal indicative of the measured reaction. The test device (10) also includes a processor (32) that is electronically coupled to the measuring unit (28) and is adapted to determine the analyte concentration in the sample in response to receiving the signal indicative of the measured reaction from the measuring unit (28). Electronically coupled to the processor (32) is a memory (34), the memory (34) for storing the analyte concentration and including storage of a current sample and at least one past sample. The test device (10) further includes a user display (18) that is also electronically coupled to the processor (32), and a display automatically displaying the concentration of the current sample and at least one past sample in a graph.Type: ApplicationFiled: December 15, 2005Publication date: June 5, 2008Inventors: KC Shu Kun Chang, Jeffery S. Reynolds, Benjamin Rush
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Patent number: 7373256Abstract: This invention pertains generally to the field of multivariate statistics, and in particular to new methods for the analysis (e.g., chemometrics) of chemical, biochemical, and biological data, including, for example, spectral data, including but not limited to nuclear magnetic resonance (NMR) spectral data. These methods are useful, for example, in metabonomics, proteomics, transcriptomics, genomics, etc., and form a part of other methods, for example, methods for the identification of chemical species, methods for the identification of biomarkers that are useful in methods of classification, diagnosis, prognosis, etc.Type: GrantFiled: April 6, 2006Date of Patent: May 13, 2008Inventors: Jeremy K. Nicholson, Elaine Holmes, Olivier Cloarec, Derek J. Crockford, John C. Lindon, Mattias Rantalainen
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Patent number: 7366617Abstract: A method for determining the masses of ions of a sample that contains a known class of biopolymers and is measured with a mass spectrometer having a statistical or pseudo-statistical error distribution includes acquiring a mass spectrum of ions of biopolymers of the known class in the sample in which mass spectrum the mass values of ions of biopolymers from the known class are concentrated in known distributions around a set of most probable mass values. At least one measured mass value of the mass spectrum is replaced by that one of a set of most probable mass values that is nearest to the measured mass value, or by a weighted average of the measured mass value averaged with that one of the set of most probable mass values that is nearest to the measured mass value.Type: GrantFiled: November 12, 2002Date of Patent: April 29, 2008Assignee: Bruker Daltonik GmbHInventors: Jens Decker, Michael Kuhn, Marcus Macht
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Patent number: 7365539Abstract: The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named “GFT NMR spectroscopy”, which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the “sampling limited” data collection regime. Concomitantly, the analysis of the resulting checmical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.Type: GrantFiled: October 26, 2004Date of Patent: April 29, 2008Assignee: The Research Foundation of State University of New YorkInventors: Thomas A. Szyperski, Seho Kim, Hanudatta S. Atreya
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Patent number: 7363800Abstract: An apparatus for measuring compositional parameters of solid, liquid, and gas components of a mixture flowing in a pipe is presented. The apparatus combines three different compositional measurements (e.g., the speed of light (microwave), the speed of sound (sonar), and mass loading of vibrating tubes or absorption of radiation) simultaneously to provide a real time, multi parameter, compositional measurement of gas-entrained mixtures.Type: GrantFiled: May 17, 2005Date of Patent: April 29, 2008Assignee: CiDRA CorporationInventor: Daniel L. Gysling
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Patent number: 7365311Abstract: Methods, systems and mediums are disclosed for aligning mass spectrometry data before the analysis of the mass spectrometry data. The mass spectrometry data may be received from a mass spectrometry machine, and re-sampled using a smooth warping function. To estimate the warping function, a synthetic signal is build using, for example, Gaussian pulses centered at a set of reference peaks. The reference peaks may be designated by users or calculated after observing a group of spectrograms. The synthetic signal is shifted and scaled so that the cross-correlation between the mass spectrometry data and the synthetic signal reaches its maximum value.Type: GrantFiled: September 8, 2005Date of Patent: April 29, 2008Assignee: The MathWorks, Inc.Inventor: Lucio Cetto
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Patent number: 7363114Abstract: There is disclosed a system and method of formulating a batch comprising at least two chemicals. An embodiment is disclosed wherein a feedforward algorithm can be used to control the target blend. Subsequently a feedback closed loop control loop algorithm is provided for a multivariant blend. Use of this approach allows for a continuously autoreplenished and controlled blend. Also disclosed is the ability to control via feedforward and feedback algorithms a fast responding control mode that allows for the elimination of a container. This approach will allow for “one pass” blending with control. The controller implements an automated fault detection and correction system, thereby identifying necessary maintenance prior to failure. If failure does occur the signature recognition allows rapid analysis and correction thus maximizing tool availability.Type: GrantFiled: July 10, 2006Date of Patent: April 22, 2008Assignee: Tres-Ark, Inc.Inventors: Gary R. Anderson, Matt Fowler
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Patent number: 7363115Abstract: There is disclosed a system and method of formulating a batch comprising at least two chemicals. An embodiment is disclosed wherein a feedforward algorithm can be used to control the target blend. Subsequently a feedback closed loop control loop algorithm is provided for a multivariant blend. Use of this approach allows for a continuously autoreplenished and controlled blend. Also disclosed is the ability to control via feedforward and feedback algorithms a fast responding control mode that allows for the elimination of a container. This approach will allow for “one pass” blending with control. The controller implements an automated fault detection and correction system, thereby identifying necessary maintenance prior to failure. If failure does occur the signature recognition allows rapid analysis and correction thus maximizing tool availability.Type: GrantFiled: July 10, 2006Date of Patent: April 22, 2008Assignee: Tres-Ark, Inc.Inventors: Gary R. Anderson, Matt Fowler
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Patent number: 7359804Abstract: A system and method is provided for obtaining calibration curves for CO and CO2 during laboratory calibration of one or more remote emissions sensing (RES) instruments, and for self-calibration of on-road RES instruments to compensate for changes in background CO and CO2 column densities.Type: GrantFiled: August 25, 2005Date of Patent: April 15, 2008Assignee: Environmental Systems Products Holdings Inc.Inventors: Mitchell Jared Williams, Donald H. Stedman
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Patent number: 7356446Abstract: A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.Type: GrantFiled: August 10, 2006Date of Patent: April 8, 2008Assignee: Hitachi, Ltd.Inventors: Masahito Ito, Kisaburo Deguchi
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Patent number: 7349812Abstract: Method for determining the titer (concentration) of biological agents, such as viral vectors for gene transfer, in real time, in living target cells and uses thereof in the field of gene therapy and diagnosis.Type: GrantFiled: April 28, 2006Date of Patent: March 25, 2008Assignee: Nautilus BiotechInventor: Manuel Vega
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Patent number: 7349809Abstract: A method for non-targeted complex sample analysis which involves the following steps. A first step involves providing a data base containing identifying data of known molecules. A second step involves introducing a complex sample containing multiple unidentified molecules into a Fourier Transform Ion Cyclotron Mass Spectrometer to obtain data regarding the molecules in the complex sample. A third step involves comparing the collected data regarding the molecules in the complex sample with the identifying data of known molecules in order to arrive at an identification through comparison of molecules in the sample.Type: GrantFiled: July 30, 2002Date of Patent: March 25, 2008Assignee: Yol Bolsum Canada Inc.Inventor: Dayan Burke Goodenowe
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Patent number: 7349760Abstract: A system for measuring and controlling the concentration of a chemical agent in a solution has a reaction cell for receiving a sample, a titrant dropper for releasing one or more drops of titrant into the sample, a first photosensor for sensing disruptions of light for every drop of titrant released, and a controller that communicates with the photosensor and computes the concentration of the chemical agent based on the number of disruptions of light at the photosensor. The present invention also includes a method for sensing and controlling the concentration of a chemical agent in a solution. The method includes having a sample containing the chemical agent, triggering the release of a number of drops of titrant into the sample, detecting the number of drops released into the sample, and computing the concentration of the chemical agent in the sample based on the number of drops of titrant released into the sample.Type: GrantFiled: March 13, 2002Date of Patent: March 25, 2008Assignee: Ecolab Inc.Inventors: Guang-jong Jason Wei, Tim Gutzmann, Paul Schacht, Tom Batcher
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Patent number: 7346458Abstract: A robust genotyping method using a DNA chip is provided. In the DNA chip used in the genotyping method, optimal probe pairs of a wild-perfect match probe and a mutant-perfect match probe are immobilized for each mutation site on a substrate. The method includes setting up a genotyping algorithm using data obtained from hybridization of an identified standard nucleic acid to the DNA chip, and genotyping an unknown target nucleic acid by substituting input vectors that are calculated from hybridization of the target nucleic acid to the DNA chip into the genotyping algorithm. The results of genotyping the target nucleic acid using the optimal probe pairs for each mutation site are statistically robust to errors.Type: GrantFiled: January 23, 2004Date of Patent: March 18, 2008Assignee: Samsung Electronics Co., Ltd.Inventors: Hyeong-sop Shim, Tae-sung Park, Jae-shick Yang
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Patent number: 7345275Abstract: There is provided a mass spectrometric based method for sample identification, including the steps of introducing sample compounds into a vacuum chamber of a mass spectrometer in a seeded supersonic molecular beam, ionizing with electrons the sample compounds, being vibrationally cold molecules, in the supersonic molecular beam during their flight through an electron ionization ion source, mass analyzing the ionized sample compounds with a mass analyzer of a mass spectrometer to obtain a mass spectrum of at least one compound in the sample, identifying the molecular ion group of isotopomers in the mass spectrum, generating various molecular elemental formulas from the identified molecular ion and a pre-allocated list of elements, reducing the number of the molecular elemental formulas by the incorporation of chemical valence considerations and constraints, calculating isotope abundances for the generated elemental formulas, comparing the calculated isotope abundances with the experimentally obtained mass specType: GrantFiled: December 16, 2005Date of Patent: March 18, 2008Inventors: Aviv Amirav, Tal Alon
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Publication number: 20080065334Abstract: The present invention relates to a space-invariant independent component analysis and electronic nose for detection of selective chemicals in an unknown environment, and more specifically, an approach to analysis of sensor responses to mixtures of unknown chemicals by an electronic nose in an open and changing environmentType: ApplicationFiled: September 7, 2006Publication date: March 13, 2008Inventors: Tuan Duong, Margaret Ryan
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Publication number: 20080059079Abstract: There is provided a chromatograph analyzing device, in which results of a quantitative calculation process on an unseparated peak have less dispersion. The chromatograph analyzing device according to the present invention automatically executes a base line setting process on the unseparated peak using base line setting conditions set in advance.Type: ApplicationFiled: August 8, 2007Publication date: March 6, 2008Inventors: Osamu Watabe, Masahito Ito
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Patent number: 7340350Abstract: The present invention relates to methods, systems, and computer readable media for deriving chemical compositions that are present in a chemical product to be manufactured and for determining whether the chemical product complies with government regulations. A method can comprise obtaining a bill of material including components to manufacture the chemical product; ascertaining whether any of the components includes subcomponents; replacing any components including subcomponents with the subcomponents in a revised bill of material; and deriving from the revised bill of material the chemical compositions present in the manufactured chemical product. In some embodiments, the derived chemical compositions can be compared to a stored set of government regulatory standards relating to the chemical compositions to determine compliance.Type: GrantFiled: October 6, 2004Date of Patent: March 4, 2008Assignee: Eastman Chemical CompanyInventors: Craig Andrew Niermann, Paul Jayaraj Rajiah, Steven James Ankabrandt, Bryan Robert Swenson, Abraham James Cox, D. Russell Hickman
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Patent number: 7337074Abstract: A method and the apparatus for determining the mass of portioned units of active substances, in particular capsules, tablets or dragees, involves leading the units of active substances through a microwave resonator and determining the mass from the displacement of the resonant frequency and the broadening of the resonance curve.Type: GrantFiled: April 6, 2004Date of Patent: February 26, 2008Inventors: Rainer Herrmann, Stefan Zaage, Udo Schlemm
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Patent number: 7332275Abstract: A method for detecting methylated nucleotides within a nucleic acid sample is provided. The method includes the steps of splitting a nucleic acid sample into separate reaction vessels; contacting nucleic acid in one reaction vessel with bisulfite; amplifying the nucleic acid in each reaction vessel; cleaving the nucleic acids in each reaction vessel to produce fragments thereof; and obtaining a mass spectrum of the resulting fragments from one reaction vessel and another mass spectrum of the resulting fragments from another reaction vessel.Type: GrantFiled: October 15, 2002Date of Patent: February 19, 2008Assignee: Sequenom, Inc.Inventors: Andreas Braun, Dirk Van Den Boom, Christian Jurinke
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Publication number: 20080040049Abstract: In the past, comparison of mean values or variances measured from multiple subjects with one another has been a mainstream of diagnostic support to be achieved using cerebral activity signals. However, in this case, it is hard to absorb individual differences, and the precision in a diagnostic support technology is low. In order to improve the precision in the diagnostic support technology, the property of data acquired by an optical organism measurement system is utilized in order to create and display information representing a change in the condition of each person. Thus, diagnosis of each person is effectively supported. Measured light signals are used to calculate and record changes in the concentrations of oxidized hemoglobin (Hb), deoxidized Hb, and total Hb respectively.Type: ApplicationFiled: June 8, 2005Publication date: February 14, 2008Inventors: Hiroki Sato, Atsushi Maki, Tsuyoshi Yamamoto, Masashi Kiguchi
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Publication number: 20080015791Abstract: A method of producing a finish for a paper substrate, wherein the finish provides the paper substrate with a color that matches the color of a target object. In accordance with the method, calculations are performed to determine the quantities of at least one group of colorants required to produce a semitransparent wood stain from a vehicle, wherein when the semitransparent wood stain is applied to the paper substrate, the paper substrate will have a color that matches the target object. The calculations are performed using reflectance measurements of the target object obtained using a spectrophotometer and previously obtained spectral data of the colorants as applied to a paper substrate. The colorants used to form the transparent or semitransparent wood stain do not include a white colorant or black-and-white masstone.Type: ApplicationFiled: April 17, 2007Publication date: January 17, 2008Inventors: Maurizio Brini, Barbara Bartolomei
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Patent number: 7319934Abstract: A method for determining acoustic parameters of a liquid (1) in a resonator arrangement having a resonator chamber (2) includes the following steps: acoustic excitation of the liquid in the resonator chamber (2) in such a way that a sequence of liquid resonances is excited in a frequency range in which the wall material of the resonator chamber (2) and/or associated transducers (6) have natural resonances with amplitude different from zero, and measurement of the associated resonance frequencies of the liquid in the resonator chamber (2); determining an observed deviation of the measured resonance frequencies from ideal resonance frequencies in an ideal resonator corresponding to the resonator chamber (2); calculating a simulation function (yk), which is a function of the acoustic parameters of the liquid (1) and represents calculated deviations of the resonance frequencies from the ideal resonance frequencies; adapting the calculated deviations to the observed deviations through variation of the acoustic parType: GrantFiled: July 29, 2002Date of Patent: January 15, 2008Assignee: TF Instruments GmbHInventors: Theodor Funck, Leo De Maeyer
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Patent number: 7313483Abstract: The invention disclosed herein employs an algorithm, the Gas Formation Model (“GFM”), to calculate the formation of free gas in a human body. The GFM is based on a novel theory of the formation of free gas relative to the physiology of the human cardiovascular system. Additionally, the GFM utilizes a novel means for the solution of integro-differential equations, the type of equations that derive from the introduction of physiological parameters. GFM-based dive computers utilize novel inputs, including a measure of exercise at depth to reflect the state of an individual's cardiovascular system. GFM-based dive computers also produce novel outputs, including the actual volume of free gas present in a diver's cardiovascular system. The GFM is implemented as a practical computational tool by means of a incorporating the algorithm into a dive computer.Type: GrantFiled: October 21, 2005Date of Patent: December 25, 2007Inventors: Steven Crow, John Lewis
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Publication number: 20070284520Abstract: An exact centroid spectrum with a mass number corrected is determined from a profile spectrum adjacent to a plurality of peaks. Regarding a profile spectrum determined by a mass spectrometer, overlapping with adjacent peaks occurs, and compounds having a plurality of peaks with different overlapping degrees is measured, a correction function is created from a relationship between an overlapping degrees with respect to the plurality of peaks and a shift of the mass number, and a centroid peak is corrected by the correction function when the profile spectrum is converted into the centroid spectrum.Type: ApplicationFiled: April 25, 2007Publication date: December 13, 2007Applicant: SHIMADZU CORPORATIONInventor: Yoshitake Yamamoto
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Patent number: 7305319Abstract: Methods and systems for controlling motion of and optically tracking a mechanically unattached probe (202) in three-dimensions are disclosed. A mechanically unattached magnetic probe (202) is placed in the system under test. The position of the probe is optically tracked in three dimensions by sensing light scattered by the probe and direct light from a light source. Magnetic poles (200) positioned about the probe are selectively magnetized to control motion of the probe in three dimensions by minimizing error between a sensed position and a desired position. In one implementation, the coil currents are time division multiplexed such that the average force on the probe produces motion in a desired direction.Type: GrantFiled: September 30, 2002Date of Patent: December 4, 2007Assignee: The University of North CarolinaInventors: Leandra Vicci, Richard Superfine
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Patent number: 7297940Abstract: Apparatus, methods, and program products are disclosed that classify spectral peaks in dissociation spectrum data and thereby improves the efficiency of molecular sequencing.Type: GrantFiled: May 3, 2005Date of Patent: November 20, 2007Assignee: Palo Alto Research Center IncorporatedInventor: Marshall W. Bern
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Patent number: 7297408Abstract: A coating for sensor transducers that transmit a signal to—and/or receive a signal from—a fluid, either liquid or gas, in contact with the transducer. In particular the coating minimizes or eliminates fouling of the transducer surface by the fluid, reducing the need for transducer maintenance, while not interfering with the transducer's ability to send and/or receive signals.Type: GrantFiled: November 16, 2004Date of Patent: November 20, 2007Assignee: The Lubrizol CorporationInventors: Joseph W. Pialet, Carlos A. Piedrahita, William P. Taylor
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Patent number: 7289912Abstract: In a method of estimating a component concentration of a mixture, and an apparatus for performing the method, the method includes generating a global calibration model with respect to a calibration data set using a concentration value determined by a plurality of independent variables including a predetermined specific component, a concentration of which is intended to be estimated, as a dependent variable, dividing the calibration data set into at least two small groups according to a value of the dependent variable and generating local calibration models for each of the at least two small groups using the calibration data set included in the divided at least two small groups, and determining a small group to which a spectrum of the mixture belongs and estimating a concentration of the specific component using a local calibration model of the determined small group.Type: GrantFiled: October 15, 2004Date of Patent: October 30, 2007Assignee: Samsung Electronics Co., Ltd.Inventor: Sang-joon Han
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Patent number: 7286942Abstract: A system and method of fluctuation enhanced gas-sensing using SAW devices includes processes for improved chemical analyte detection, identification, and quantification through the measurement and spectral analysis of frequency fluctuations in the instantaneous frequency of a chemical sensor arranged to produce an oscillatory output signal when exposed to chemical substances. The system and method may use a chemical sensor, such as a surface acoustic wave (SAW) device. The spectral analysis produces the power spectral density of the frequency fluctuations, which are represented as a pattern that includes information about the analyte(s) such as, total adsorbed gas mass and diffusion coefficients. The diffusion coefficients may then be used to determine the number of molecule types and/or the concentration of each.Type: GrantFiled: October 2, 2003Date of Patent: October 23, 2007Assignee: United States of America as Represented By The Secretary of the NavyInventors: Laszlo B. Kish, Gabor Schmera
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Patent number: 7277799Abstract: The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to methods for processing data obtained therefrom. Disclosed is an improved method for filtering low intensity mass spectral data. More specifically, the invention provides a method for use with digitized mass spectra that facilitates the distinction between low level signals and noise using the correlation of signals therein based on their mass differences.Type: GrantFiled: February 9, 2005Date of Patent: October 2, 2007Assignee: Bruker Daltonics, Inc.Inventor: Melvin A. Park
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Patent number: 7269527Abstract: A sensor interface system and a sensor integration module support individual sensors and sensor arrays, with network connectivity and critical functions required for analog and digital sensors when deployed in field applications used for chemical, biological, radiation, nuclear and explosives (CBRNE) material identification. The sensor integration module enables efficient integration of a single sensor or for multiple sensors into an array using a modular sensor interface unit and provides individual TCP/IP addresses for each detector element, signal processing for the sensor data and communications capabilities establishing each detector and the sensor array as network elements on a distributed network.Type: GrantFiled: January 17, 2007Date of Patent: September 11, 2007Assignee: Innovative American Technology, Inc.Inventor: David L. Frank
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Patent number: 7269519Abstract: The present invention provides a method for identifying a member of a mass-coded combinatorial library which is a ligand for biomolecule and assessing the effect of the binding of the ligand to the biomolecule. The mass-coded molecular library comprises compounds of the general formula XYn, wherein n is an integer from 2 to about 6, X is a scaffold and each Y is, independently, a peripheral moiety. The mass-coded combinatorial library is produced by reacting a scaffold precursor with a sufficient number of distant peripheral moiety precursors such that there exist at least about 250 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors.Type: GrantFiled: March 11, 2003Date of Patent: September 11, 2007Assignee: Schering CorporationInventors: Huw M. Nash, Seth Birnbaum, Edward A. Wintner, Krishna Kalghatgi, Gerald Shipps, Satish Jindal
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Patent number: 7267796Abstract: The preparative liquid chromatograph uses a plurality of detectors including a mass spectrometer, and a chromatogram generator is provided for generating a plurality of chromatograms each corresponding to each of the plurality of detectors. The plurality of chromatograms are converted into a respective binary signal by comparing the chromatogram with a predetermined threshold, and a logical operator performs a binary operation on the plurality of respective binary signals, whereby a resultant binary signal is generated. A separation controller controls the fraction collector of the preparative liquid chromatograph based on the resultant binary signal to separate components from a sample. When “AND” is used as the binary operation, the resultant binary signal is “1” only when all the respective binary signals are “1”. This assures a high precision, high purity separation where an impurity mingling is minimized.Type: GrantFiled: July 11, 2003Date of Patent: September 11, 2007Assignee: Shimadzu CorporationInventor: Hiroaki Waki
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Patent number: 7259279Abstract: Process for the hydroformylation of olefins by linkage of the input parameters prevailing in the hydroformylation reaction to the target parameters of a hydroformylation reaction, wherein the linkage is achieved by means of at least one synthetic neuronal network.Type: GrantFiled: November 15, 2005Date of Patent: August 21, 2007Assignee: Oxea GmbHInventors: Dietmar Thiel, Carl Dieter Frohning
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Patent number: 7255474Abstract: A library of material samples is provided in a condition suitable for imaging using infrared (IR) spectroscopy. The samples are provided to one or more detection cells, each of the cells including or containing a reflective surface. Preferably, for imaging, an energy source (e.g. a source of infrared radiation) provides energy to the detection cells to interact with the samples. Thereafter, images (e.g., spectra) related to the samples are created based upon the interaction.Type: GrantFiled: July 28, 2004Date of Patent: August 14, 2007Assignee: Symyx Technologies, Inc.Inventors: Peijun Cong, Shenheng Guan, Stephen Cypes, Jason Wells, H. Sam Bergh
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Patent number: 7251569Abstract: Methods, systems, and computer program products for analyzing a product are disclosed. The product includes parts supplied by suppliers. Each part includes materials, each material includes substances, and each substance has a respective substance amount. A database includes relationship information for the product, parts, materials, substances and substance amounts. The product is analyzed by, first, receiving instructions to select at least one of the product, the parts, or the materials for analysis. Next, responsive to the received instructions, relationship information is retrieved from the database for the selected product, parts, and materials. Finally, the retrieved relationship information is processed to determine at least one of (1) a materials breakdown or (2) a compliance status for the selected product, parts, or materials.Type: GrantFiled: January 26, 2005Date of Patent: July 31, 2007Assignee: Synapsis Enterprise LLCInventors: P. German Avila, William F. Hoffman, III, Kurk W. Kan, Andrew M. Wertkin
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Patent number: 7248993Abstract: Disclosed is a method for measuring the available remaining hydrogen capacity of a non-replaced hydrogen storage canister. After the original hydrogen capacity of the hydrogen storage canister is read, the used hydrogen capacity of the hydrogen storage canister is read and remaining hydrogen capacity formula is employed to determine the available remaining hydrogen capacity of the hydrogen storage canister. For a fully charged or newly-installed hydrogen storage canister, the process includes reading the number of cycles of operation of the hydrogen storage canister, reading the original hydrogen capacity of the hydrogen storage canister, reading the used hydrogen capacity of the hydrogen storage canister, and then employing the remaining hydrogen capacity formula to determine the available remaining hydrogen capacity of the hydrogen storage canister.Type: GrantFiled: April 17, 2006Date of Patent: July 24, 2007Assignee: Asia Pacific Fuel Cell Technologies, Ltd.Inventors: Yaw-Chung Cheng, Yao-Sheng Hsu
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Patent number: 7244621Abstract: A method for interpreting data that is produced after a group of amino acids and acylcarnitines are derivatized from blood spots taken from newborn babies and scanned by a tandem mass spectrometer. Concentration levels of each metabolite, which are directly proportional to the butyl ester fragment after derivatization, are compared to threshold flags for determining a significance of any deviation of the metabolite relative to the flag threshold. The threshold flags are diagnostic limits to the data retrieved from each blood spot. The data includes metabolite concentrations and molar ratios of metabolites with other metabolites. Samples are labeled normal for a disease if the concentration of any of the metabolite concentrations or molar ratio concentration do not deviate from the flag threshold, but, in contrast, the sample must be further evaluated if a value is elevated or deficient to some degree.Type: GrantFiled: September 20, 2005Date of Patent: July 17, 2007Assignee: Pediatrix Screening, Inc.Inventor: Donald H. Chace
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Patent number: 7240313Abstract: A method for determining material density variations and prediction of defects on a multi-layer printed circuit board (PCB), in the X, Y, and Z axis, includes a virtual grid creation system and a set of rules for determining the material density in each grid element in the grid system.Type: GrantFiled: June 27, 2003Date of Patent: July 3, 2007Assignee: TTM Technologies, Inc.Inventor: Andrew James Cameron
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Patent number: 7238531Abstract: A method for interpreting data that is produced after a group of amino acids and acylcarnitines are derivatized from blood spots taken from newborn babies and scanned by a tandem mass spectrometer. Concentration levels of each metabolite, which are directly proportional to the butyl ester fragment after derivatization, are compared to threshold flags for determining a significance of any deviation of the metabolite relative to the flag threshold. The threshold flags are diagnostic limits to the data retrieved from each blood spot. The data includes metabolite concentrations and molar ratios of metabolites with other metabolites. Samples are labeled normal for a disease if the concentration of any of the metabolite concentrations or molar ratio concentration do not deviate from the flag threshold, but, in contrast, the sample must be further evaluated if a value is elevated or deficient to some degree.Type: GrantFiled: June 28, 2005Date of Patent: July 3, 2007Assignee: Pediatrix Screening, Inc.Inventor: Donald H. Chace
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Patent number: 7235214Abstract: A molecular contamination monitoring system includes a piezoelectric measurement sensor exposed to a molecular constituent to be measured; a piezoelectric reference sensor; and a filter for filtering said molecular constituent, the filter located between the reference sensor and the measurement environment. The reference sensor is exposed to the same ambient conditions of temperature, pressure and humidity as the measurement sensor. Alternatively, there may be a plurality of different reference sensors having different filters, or there may be a plurality of different measurement sensors.Type: GrantFiled: April 23, 2003Date of Patent: June 26, 2007Assignee: Particle Measuring Systems, Inc.Inventors: Daniel Rodier, Scott Waisanen, Dale Griffin
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Patent number: 7233865Abstract: The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.Type: GrantFiled: July 6, 2006Date of Patent: June 19, 2007Assignee: Caliper Life Sciences, Inc.Inventor: Ring-Ling Chien
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Patent number: 7231301Abstract: The present application provides a method for predicting the functional site of a protein using data of the entire proteins of an organism of which genome data or cDNA data is known. More specifically, the present application provides a method for predicting a protein functional site, comprising the steps of calculating the frequency of occurrence of an oligopeptide in the entire proteins, calculating the value of each amino-acid residue contributing to the frequency of occurrence as the representative value of the function, and predicting the protein functional site by using the representative value of function as an indicator. The present also provides a system for predicting a functional site for automatically performing said methods.Type: GrantFiled: January 16, 2003Date of Patent: June 12, 2007Assignee: Japan Science and Technology CorporationInventors: Hirofumi Doi, Hideaki Hiraki, Akio Kanai
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Patent number: 7229834Abstract: A method for interpreting data that is produced after a group of amino acids and acylcarnitines are derivatized from blood spots taken from newborn babies and scanned by a tandem mass spectrometer. Concentration levels of each metabolite, which are directly proportional to the butyl ester fragment after derivatization, are compared to threshold flags for determining a significance of any deviation of the metabolite relative to the flag threshold. The threshold flags are diagnostic limits to the data retrieved from each blood spot. The data includes metabolite concentrations and molar ratios of metabolites with other metabolites. Samples are labeled normal for a disease if the concentration of any of the metabolite concentrations or molar ratio concentration do not deviate from the flag threshold, but, in contrast, the sample must be further evaluated if a value is elevated or deficient to some degree.Type: GrantFiled: September 13, 2005Date of Patent: June 12, 2007Assignee: Pediatrix Screening, Inc.Inventor: Donald H. Chace
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Patent number: 7230233Abstract: A programmed computer analyzes data from a mass spectrometer. A spectrum corresponding to an unknown sample is perturbed in various ways, and each perturbed spectrum is compared with the spectrum of a known or reference substance. The perturbed spectrum having the highest correlation with the known spectrum, and which is also physically plausible, is considered to be the best fit. The method indicates in what specific ways the unknown sample differs from, or is similar to, the known substance.Type: GrantFiled: March 21, 2006Date of Patent: June 12, 2007Assignee: Novatia, LLCInventors: Jeffrey L. Whitney, David J. Detlefsen, Mark E. Hail
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Patent number: RE39871Abstract: A novel basic allergen/particulate data collection device and a novel multi-function personal air quality management device are disclosed. Both devices include sensor sub-assembly detecting and reporting on allergen/particulate data (preferably, for allergen/particulate with sizes smaller than 5 micron) for an indoor location (where the asthma patient is situated). Both devices are communication enabled to allow the allergen/particulate data to be provided to an air/asthma advice server, to generate air/asthma advice for an asthma patient, taking into consideration the allergen/particulate data as well as air quality data for a surrounding outdoor area of the indoor location. In one embodiment of the basic device, the communication interface is tailored for “harsh environment” local area networking.Type: GrantFiled: May 13, 2005Date of Patent: October 9, 2007Assignee: AirAdvice, Inc.Inventor: John N. Skardon
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Patent number: H2216Abstract: For use in estimating or predicting bioaccumulation of a chemical analyte, even a surfactant, log Pow values for the analyte may be determined by calculating the log of the ratio of the concentrations of the analyte in n-octanol and in water, equilibrated using a slow-stir method. In this method, samples of the analyte are prepared and stirred in n-octanol and water (or other largely immiscible solvents) at a rate sufficiently low to avoid emulsions over time at a constant temperature. After stirring, the n-octanol layer and the water layer are sampled and the quantity of analyte in each measured.Type: GrantFiled: February 14, 2004Date of Patent: May 6, 2008Assignee: Halliburton Energy Services, Inc.Inventors: Arron L. Karcher, J. Michael Wilson