Abstract: A method and system for nuclear substance revealing using muon detection technique is presented. In some aspects, naturally occurred muons are selected from the flow of charged particles. Muon coordinate and incidence angle measured above and below the interrogated volume can be used for the decision making on the presence of nuclear substance inside the volume. The system is adapted for performing measurements on moving objects such as moving trucks. A combination of the nuclear substance detection system with an explosive sensing system is presented.

Abstract: Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations, vital signs and physiological information such as a malignant condition are provided. In some embodiments, the optical sensor includes an array of photodetectors, where each photodetector is configured to detect a spectrum of light. In some embodiments, the image processing device receives a live still or video electronic image, or alternatively, the electronic image is provided from an electronic storage media. Exemplary physiological parameters include but are not limited to a pulse rate, a biophysical or physiological property of skin, a cardiovascular property, a property related to an organ such as the liver or the kidneys, and a temperature fluctuation.

Abstract: The present invention is a comprehensive two-dimensional gas chromatograph system and method including a modulator wherein the pulsing of the modulator is synchronized with data acquisition so that the results are reproducible.

Abstract: A system and a method for monitoring a building material are disclosed. The system and the method provide a comprehensive monitoring throughout a manufacturing and an application process and provide a real time data feedback relating to the physical characteristics of the building material. The system and method include mixing a predetermined amount of taggant particles with a predetermined volume of at least one component of the building material in order to comprehensively monitor a mix ratio and segregation of the building material during manufacturing and application.

Abstract: Systems and methods for assessing and optimizing energy use and environmental impact can be designed to receive energy consumption and emission data from one or more energy consumption sources of a facility over a network. The data can be transformed into a database format that can be processed and analyzed. The data can be validated according to predefined validation rules. The data can be aggregated according to predefined time intervals and stored in memory. The data can be used to generate a report to a user, for example, via a user interface.

Abstract: A method for determining proportion of diesel fuel in a lubricating oil of a combustion engine, including: forming a mixture containing an oil sample and a C5 hydrocarbon such as a C5 alkane; injecting the mixture into the injector of a gas chromatograph; establishing a chromatograph of the sample; determining a first parameter M representative of the area of a peak associated with the C5 hydrocarbon such as a C5 alkane; determining a second parameter C representing of the area of at least one peak associated with a hydrocarbon representative of diesel fuel; and determining the proportion T of diesel fuel by a formula T = C / ( M ) - b a in which a and b are constants defining equation y=ax+b of a calibration straight line of the ratio between the second and the first parameters as a function of the proportion of diesel fuel.

Abstract: A method and apparatus for interfacing a plurality of volumetric measurement systems, each of which includes a gas measurement and a flow measurement system, to a host system via an interface unit.

Abstract: The invention relates to a method for the qualitative and quantitative analysis of samples by optical emission spectroscopy with laser excitation (18), using a database created on single-element aqueous solutions all having the same pure element concentration, this database containing, for each element, the wavelengths of the emission lines and their respective intensities.

Abstract: The total film thickness T1N of silicon oxynitride film and silicon oxide film remaining as its underlying layer is measured. A measurement target substrate is re-oxidized, and, after the re-oxidization, the total film thickness (T2N) of the silicon oxynitride film, silicon oxide film and silicon oxide film resulting from the re-oxidization on the target substrate is measured. Separately, a reference substrate provided with silicon oxide film is re-oxidized, and, after the re-oxidization, the total film thickness T2 of the silicon oxide film and silicon oxide film resulting from the re-oxidization on the reference substrate is measured. Re-oxidization rate reduction ratio RORR of the measurement target substrate is calculated by the following formula (1) from the values of total film thicknesses T1N, T2N and T2. The nitrogen concentration of the silicon oxynitride film of the target substrate is determined from the calculated re-oxidization rate reduction ratio RORR. RORR (%)={(T2?T2N)/(T2?T1N)}×100 (1).

Abstract: The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.

Abstract: Systems and methods for unmixing spectroscopic data using nonnegative matrix factorization during spectrographic data processing are provided according to various embodiments. In an embodiment, a method of processing spectrographic data may include receiving optical absorbance data associated with a sample and iteratively computing values for component spectra using nonnegative matrix factorization. The values for component spectra may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of a pathlength matrix and a matrix product of a concentration matrix and a component spectra matrix. The method may also include iteratively computing values for pathlength using nonnegative matrix factorization, in which pathlength values may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of the pathlength matrix and the matrix product of the concentration matrix and the component spectra matrix.

Abstract: A digital scale is provided that switches a measuring interval according to the amount of variation of sampled data, and computes a weight. Embodiments include a scale with pre-stored scale intervals set at multiple levels, and allowable ranges of fluctuation that correspond to the scale intervals. The scale acquires digital data of a load continuously, and computes a predetermined number, or a fluctuation range in a predetermined time, of the acquired digital data. The scale then determines the degree of variation of the digital data by comparing the computed fluctuation range with the allowable range of fluctuation stored for each scale interval, and switches the scale interval based on the determined degree of variation, thereby allowing the scale to measure and compute the weight of the load even if the fluctuation is large.

Abstract: The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized.

Abstract: A vapor analysis system comprising a vapor analyzer capable of collecting and analyzing a vapor sample for detection of a compound that may be contained within the vapor sample. A controller is coupled to the vapor analyzer. The controller is programmed to produce an indicator signal indicative of a relative concentration of the compound detected by the vapor analyzer within the vapor sample. A sample probe includes a housing containing a vapor channel through which the vapor sample is collected, and a vapor cable couples the sample probe to the vapor analyzer to allow collection and channeling of the vapor sample to the vapor analyzer. A multi-dimensional user indicator is disposed on the housing of the sample probe receives and operates in response to the indicator signal to indicate the relative concentration of the compound detected within the vapor sample for presentation via a multi-directional stimulus to a user of the vapor analysis system.

Abstract: According to various embodiments, variables are grouped in an unsupervised manner after principal component analysis of a plurality of variables from a plurality of samples. A number of principal components are selected. A subset principal component space is created for those components. A starting variable is selected. A spatial angle is defined around a vector extending from the origin to the starting variable. A set of one or more variables is selected within the spatial angle. The set is assigned to a group. The set is removed from further analysis. The process is repeated starting with the selection of a new starting variable until all groups are found.

Abstract: Methods, systems and computer readable media for computing small particle size distributions of particles in a process stream comprising a sample dilute colloid. A reference matrix of pre-computed reference vectors is provided. Each reference vector represents a discrete particle size or particle size range of a particle size distribution of particles contained in a dilute colloid. Each reference vector represents a reference extinction spectrum over a predetermined wavelength range. A measurement vector representing a measured extinction spectrum of the sample particles in the sample colloid is provided, wherein the measured extinction spectrum has been spectrophotometrically measured over the wavelength range. The particle size distribution and particle concentrations of the particles in the sample colloid are determined using the reference matrix, the measurement vector and linear equations.

Abstract: Steric features inherent in the three dimensional disposition of atoms in molecules can be represented as multiplets using a defined set of steric descriptors. The resulting multiplets can be encoded in a compressed form of bitstring known as a bitmap. Such bitmaps can be generated in compressed form and used to compare individual conformers or ensembles of conformers of molecules to each other without decompression. Such comparisons are useful in molecular similarity analysis, in molecular diversity analysis, in database searching, and in conformational analysis.

Abstract: By specifying an initial oxygen concentration in a silicon single crystal and a concentration of thermal donors produced according to a thermal history from 400° C. to 550° C. that the silicon single crystal undergoes during crystal growth, a nucleation rate of oxygen precipitates produced in the silicon single crystal while the silicon single crystal is subjected to a heat treatment is determined. Further, by specifying the heat treatment condition of the silicon single crystal, an oxygen precipitate density and an amount of precipitated oxygen under a given heat treatment condition are predicted by calculation.

Abstract: A signal processing apparatus which has an input for receiving a signal conveying a response from first and second optical components to an optical excitation. The first and second optical components are in an optical sensor which is intended to be placed in a sensing zone. The sensing zone contains hydrogen susceptible to migrate into the optical sensor. The signal processing apparatus has a processing entity for processing the response from the first and second optical components to derive information on hydrogen concentration in the optical sensor.

Abstract: A method for analyzing data obtained from at least one sample in a separation system (10, 50, 60) that has a capability for separating components of a sample containing more than one component as a function of at least two different variables comprising obtaining data representative of the at least one sample from the system, the data being expressed as a function of the two variables; forming a data stack (70, 74, 78, 82, 84) having successive levels, each level containing successive data representative of the at least one sample; forming a data array (R) representative of a compilation of all of the data in the data stack; and separating the data array into a series of matrixes. A chemical analysis system that operates in accordance with the method, and a medium having computer readable program code for causing the system to perform the method.

Abstract: The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene product expression in a cerebrospinal fluid sample and comparing the pattern of gene product expression from the sample to a library of gene product expression pattern known to be indicative of the presence or absence of a neurodegenerative disease. The methods also provide for monitoring neurodegenerative disease progression and assessing the effects of therapeutic treatment. Also provided are kits, systems and devices for practicing the subject methods.

Abstract: A method for predicting pregnancy outcome includes measuring blood levels of hCG-hg and progesterone in a pregnant woman, determining a rate of change of progesterone levels from the blood measurements, determining at least a qualitative direction of change of hCG-hg levels from the blood measurements, comparing the determined rate of change of progesterone levels with a pre-established reference value, and determining at least a qualitative likelihood of a term pregnancy and a failed pregnancy for the woman from the qualitative direction of change of hCG-hg levels and the determined rate of change of progesterone levels relative to the pre-established reference value. The rate of change of progesterone is determined by formula as a number of days for progesterone to double.

Abstract: A method for shortening a waiting time from the setting of a sample in a chamber to the stabilisation of the intensity for a secondary ion for SIMS analysis (mass analysis of the secondary ion) using a raster variation method is provided. By approximating so that the difference between time-lapse variations in intensities of the secondary ions sequentially measured for irradiation densities of two different primary ions becomes constant, a method capable of carrying out an accurate measurement of the concentration of an impurity in consideration of background noise despite time-lapse variations in the intensities of the secondary ions is provided.

Abstract: A method of determining a concentration level of a compound in a mixture is provided. A plurality of compounds are identified in the mixture based on intensity peaks identified from NMR data generated from the mixture. A compound is selected from the identified plurality of compounds for a concentration determination. A concentration equation associated with the selected compound is determined. A first peak associated with the selected compound is selected from the NMR data. The selected first peak does not overlap with a peak associated with another compound of the identified plurality of compounds. An intensity value associated with the selected first peak is determined. A concentration of the selected compound in the mixture is calculated using the determined concentration equation and the determined intensity value.

Abstract: Process of placing a sample of known concentrations of known elements in a spectrometer; measuring the intensity II, I2 . . . In of the different elements included in the sample, by relating known concentrations C1, C2 . . . Cn for the elements included in the sample to the measured intensities II, I2 . . . In so as to calculate a fictive intensity for a 100%-pure element for each of the elements included; calculating calibration constants K1, K2 . . . Kn for each of the elements as the relationship between measured intensity II, I2 . . . In and the calculated intensity of respective 100%-pure elements; placing a sample of unknown concentrations of the elements in the spectrometer and reading-off the intensity of the different elements; and calculating the concentration of respective elements in the last mentioned sample as the measured intensity multiplied by respective calibration constants for the elements present in the sample.

Abstract: An exact centroid spectrum with a mass number corrected is determined from a profile spectrum adjacent to a plurality of peaks. Regarding a profile spectrum determined by a mass spectrometer, overlapping with adjacent peaks occurs, and compounds having a plurality of peaks with different overlapping degrees is measured, a correction function is created from a relationship between an overlapping degrees with respect to the plurality of peaks and a shift of the mass number, and a centroid peak is corrected by the correction function when the profile spectrum is converted into the centroid spectrum.

Abstract: Described is a method for recording the boiling curve of liquids, in particular petroleum products and/or solvents, in which a sample amount of the liquid to be analyzed is evaporated and subsequently condensed, wherein the vapor temperature and the respectively evaporated amount of liquid are monitored, the sample amount is dosed by a a pump, for example, wherein the pump and the condensate collection chamber are brought to a defined, and preferably identical, temperature level. The condensed volume is determined volumetrically and the distillation residue of the sample amount is determined by weighing.

Abstract: A multifunctional portable electronic device (100) that easily allows a user to test dangerous fumes level is described. A power module (10) supplies a working voltage to a gas-sensing module (12) and an output voltage of the gas-sensing module is generated after sensing gas. A signal processor converts the output voltage of the gas-sensing module into a digital signal and calculates a corresponding gas concentration value that can be displayed on a display module (18).

Abstract: Disclosed is a method of determining an initial concentration of a target nucleic acid within a sample using real-time nucleic acid amplification data. Amplification efficiencies of the target nucleic acid with respect to amplification time are obtained from signals of amplified products, and an amplification efficiency function with respect to amplification time is formulated employing the amplification efficiencies.

Abstract: A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition, a diluent and at least one reagent is prepared and analyzed using, for example, an optical detector. Response data obtained by the detector is indicative of the optical absorbance of the sample mixture as a function of time. A processor analyzes the response data to determine a corresponding best fit linear relationship. Depending upon an expected concentration range, the initial absorbance and/or the slope of the best fit equation are used to calculate the concentrations of the peracid and peroxide in the use composition.

Abstract: In a mass analysis of a sample, candidate compositions Y of a fragment ion produced by a dissociating operation are deduced from the mass of that fragment ion (Steps S6 to S9). If the number of the candidates Y is larger than a predetermined value (“No” in Step S10), the repetition counter of the dissociating operation is increased by one and the mass analysis of the fragment ion is performed again. If the number of the candidates is equal to or smaller than the predetermined value, the difference between the masses of the fragment ions before and after each mass-analyzing stage is calculated (Step S11). From this mass difference, the candidates Z of the desorption ion at each stage is deduced (Step S12). These candidates Z and Y are used to narrow down the candidate composition formulae X deduced from the mass of the precursor ion (Step S13). If the number of the candidates has decreased to one or become equal to or smaller than a predetermined value, the result is displayed (Steps S14 and S15).

Abstract: The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of m/z regions are set up for carrying out the mass analysis with the all ions included therein being dissociated collectively for each m/z region so as to obtain measurement MS2 data. By comparing the measurement MS2 data with reference MS2 data stored in a reference data base, a difference thereof is detected. For the m/z region with a differential component detected, the mass analysis is carried out collectively without dissociation for the all ions included therein so as to obtain measurement MS1 data. By comparing the measurement MS1 data with the reference MS1 data, a difference thereof is detected. From the difference thereof, a parent ion considered to be the differential component factor is presumed for carrying out the mass analysis with the same being dissociated.

Abstract: Hetero-epitaxial semiconductor materials comprising cubic crystalline semiconductor alloys grown on the basal plane of trigonal and hexagonal substrates, in which misfit dislocations are reduced by approximate lattice matching of the cubic crystal structure to underlying trigonal or hexagonal substrate structure, enabling the development of alloyed semiconductor layers of greater thickness, resulting in a new class of semiconductor materials and corresponding devices, including improved hetero-bipolar and high-electron mobility transistors, and high-mobility thermoelectric devices.

Abstract: A method for calculating the amount of solution components to add to an advanced coating removal (ACR) stripping solution in a coating removal stripping bath to replenish and recover stripping potential. The stripping effectiveness may be restored by the addition of only the primary acid of the composition of acids of the stripping bath and fresh water, in an amount necessary to restore the stripping solution to its original density.

Abstract: Various embodiments of methods and systems described herein relate to tracking and/or managing the destruction, reconstitution, or reclamation of regulated substances, including, in certain embodiments, tracking the associated GHG emissions and carbon valuation.

Abstract: A substance detection system having an electronic nose and classifier. The system may extract feature from the electronic signals representing the smells from the electronic nose sensing an unknown substance. The features may be formatted as smellprints that are synthesized as data. The features may be classified, and in a binary tournament fashion, as an illustrative example, may be mapped to be compared or correlated with features of known substances. The known substance or substances having the highest scores for good mapping, comparison or correlation with the sensed substance, may be reviewed in view of decision criteria to determine an identification of the sensed substance.

Abstract: A method for screening newborns using electrospray tandem mass spectrometry. The method improves the current protocols that use tandem mass spectrometry by assuring accurate and consistent results at the clinical level through enhanced quality controls and quality assurance protocols as applied to the scan profiling and sample preparation of blood spots from newborns. Specific additives are used in precise concentrations of internal standards, employing detailed controls adapted to distinguish twenty metabolites, which are scanned and vigorously compared to known spectra results. Revealing peaks, metabolite concentration, and scan intensities in the quality assurance steps are then compared to a range of thresholds to determine whether or not the sample is contaminated, drug-ridden, diagnosable, or unacceptable. All spectra results and quality assurance flags are organized in spreadsheet form and exported to a database where values are compiled and stored for daily output results and trend analysis.

Abstract: Systems and methods for qualifying and quantifying carbon sequestered in the ocean following ocean fertilization events are disclosed. The system and methods can be used to accurately quantify amounts of carbon sequestered and the minimum periods of time before which the sequestered carbon returned to the atmosphere as CO2. The system and methods assign quality grades to sequestered carbon by determining minimum depth thresholds associated with periods of time until which ocean water will be exposed to the atmosphere. The system can be implemented via a computer system.

Abstract: A test system for measuring the concentration of an analyte in a biological fluid sample comprises: a plurality of test members (16) in a container (10), each test member (16) including reagent means for indicating the catalytic activity of an enzyme when in the presence of a biological fluid containing an analyte acted upon by the enzyme; 0 a test meter (2) for receiving a test member (16), the meter (2) having circuitry for performing a measurement on a test member received therein to produce a measured physical value, means for determining an analyte concentration value for a specified biological fluid from said measured physical value, and means (4) for indicating a determined analyte concentration value; a Container RFID tag (14) associated with the container (10) which includes data specific to said plurality of test members (16); and a Patient RFID tag (28) which includes data specific to a patient; and wherein said test meter (2) includes means for reading and storing data from said Container RFID tag

Abstract: The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. In another aspect, methods and systems are disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid.

Abstract: A system and method for monitoring a process in a process plant and detecting an abnormal condition includes collecting data representative of the operation of the process, performing a multivariate statistical analysis to represent the operation of the process in a known state based on a set of collected reference data, where the reference data includes a statistical measure of the operation of the process in the known state. The system and method may further include representing the operation of the process in an unknown state based on a set of monitored data, where the monitored data includes a statistical measure of the operation of the process in an unknown state, and using the output of the multivariate statistical analysis as an input, and comparing the process in the unknown state to the multivariate statistical representation of the operation of the process in the known state to determine the operational state of the process.

Abstract: A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain prediction information including a cleavage pattern of a peptide and/or peak positions in a mass spectrum and/or the intensity ratio of the mass spectrum, and identifying a protein by using the prediction information and experiment information.

Abstract: Disclosed is a method for predicting the biological activity of a compound by the similarity of its drug signature score to the scores of a plurality of known drug signatures.

Abstract: A process and apparatus for sensing gas concentration in a gas stream involves producing a succession of difference values representing differences between successive sample values of a succession of sample values representing instantaneous reflectance of light from a compound produced by reacting a reagent with the gas being sensed and producing a gas concentration value in response to a maximum difference value of the succession of difference values.

Abstract: A meter adapted to determine and store an analyte concentration reading, in particular a glucose concentration reading, and including an interface having a plurality of predefined levels of user features. The predefined levels may be selected by a user based on the user's preferences, needs and abilities.

Abstract: The invention relates to a method for co-detecting and distinguishing individual polypeptide and polynucleotide molecules in a single sample analysis. The polypeptide and polynucleotide targets which emit electromagnetic radiation are labeled with probes that emit electromagnetic radiation at the same emission wavelength, are suspended in fluid and moved through an interrogation volume allowing co-detection of low concentrations of individual molecules and discrimination based on characteristics other than emission wavelength.

Abstract: A system and method are disclosed for very accurately determining a value of a substrate doping density in a metal oxide semiconductor device. A plurality of values of threshold voltage of a device under test are measured using a plurality of different values of source to substrate bias voltage. Then a linear relationship is determined between the plurality of values of threshold voltage and a plurality of different values of an expression that is a function of the source to substrate bias voltage and a function of a surface potential of the device. A very accurate value of the substrate doping density is reiteratively calculated from the linear relationship without assuming that the surface potential of the device has a constant value.

Abstract: A method for analyzing data from a mass spectrometer comprising acquiring raw profile mode data containing one or more ions and their isotopes in a mass spectral range; calculating theoretical isotope distributions for all ions of interest including native or labeled ions based on their molecular composition; convoluting the theoretical isotope distributions with target peak shape function specified during instrument calibration, actual peak shape functions, or approximated peak shape functions, to obtain theoretical isotope profiles for all ions; constructing a peak component matrix of relevant theoretical isotope profiles included as peak components; performing a weighted multiple linear regression between the profile mode data and the peak component matrix; and reporting regression coefficients as relative concentrations for each of the ions, or ranking these ions based on fitting statistics as search results. A mass spectrometer system (FIG. 1) operating in accordance with the method.

Abstract: The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires identifying and screening an initial set of signal transduction proteins against a set of toxic compounds, and determining changes in intracellular localization pattern of each of the proteins. Proteins whose changes in intracellular localization pattern are redundant are discarded from the initial set, and new proteins are added to provide a new set of proteins. I repeat the method steps with new sets of proteins until the set of proteins provides me at least 5 principal components with respect to the range of compounds marketed as small organic molecules.

Abstract: A spectroscopic identification method and system are provided that uses the primary or main spectroscopic features of a source, such as those as arising from chemical functional groups, to describe and distinguish the source. These primary spectroscopic features make up a portion (i.e., are a subset) of the entire spectroscopic data for a particular source but can nevertheless be used as the basis of separating spectra from multiple source. When analyzing spectroscopic data obtained from a sample for one or more sources, the analysis first focuses on the primary spectroscopic features for a source rather than the entire spectra for a source.