Patents Assigned to Danisco US Inc.
  • Thermolysin variants
    Patent number: 9976134
    Abstract: The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: May 22, 2018
    Assignee: DANISCO US INC.
    Inventors: David A. Estell, Ronaldus W. J. Hommes, Amy D. Liu, Andrew Shaw
  • OSMOTIC BURST ENCAPSULATES
    Publication number: 20180134997
    Abstract: Described are compositions and methods relating to an osmotic burst enzyme delivery system, osmotic burst encapsulates, and methods of use, thereof. Being transitioned to an environment of decreased osmolarity causes the osmotic burst encapsulates to rupture and release their enzyme payload. The compositions and methods have applications in laundry and dishwashing.
    Type: Application
    Filed: June 9, 2016
    Publication date: May 17, 2018
    Applicant: DANISCO US INC.
    Inventors: Mark GEBERT, Huy DOAN, Doug A. DALE
  • BGL6 beta-glucosidase and nucleic acids encoding the same
    Patent number: 9961909
    Abstract: The present invention provides a novel ?-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: May 8, 2018
    Assignee: DANISCO US INC.
    Inventors: Nigel Dunn-Coleman, Michael Ward
  • AMYLASE WITH MALTOGENIC PROPERTIES
    Publication number: 20180112203
    Abstract: The present teachings provide an amylase with maltogenic properties. Nucleic acids encoding the maltogenic amylase and variants thereof, expression vectors, formulations, and host cells are also provided. Additional embodiments of the present teachings provide various methods of use and methods of manufacturing.
    Type: Application
    Filed: November 15, 2013
    Publication date: April 26, 2018
    Applicant: DANISCO US INC.
    Inventors: RICHARD R. BOTT, LING HUA, ZHEN QIAN, CHRISTOPHER L. RIFE, JAYARAMA K. SHETTY, ZHONGMEI TANG, ZHEYONG YU, BO ZHANG
  • Glucoamylase variants with altered properties
    Patent number: 9944913
    Abstract: The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: April 17, 2018
    Assignee: Danisco US Inc.
    Inventors: Wolfgang Aehle, Piet Van Solingen, Martijn Scheffers, Richard Bott
  • Variants of cellobiohydrolases
    Patent number: 9938551
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: April 10, 2018
    Assignee: DANISCO US INC
    Inventors: Richard R. Bott, Maria Foukaraki, Ronaldus Wilhelmus Hommes, Thijs Kaper, Bradley R. Kelemen, Slavko Kralj, Igor Nikolaev, Mats Sandgren, Johannes Franciscus Thomas Van Lieshout, Sander Van Stigt Thans
  • Small enzyme-containing granules
    Patent number: 9938517
    Abstract: The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for producing such granules. The majority of the enzyme granules are less than 300 ?m in diameter. The granules are suitable for incorporation into compositions such as cleaning, textile processing, and animal feed compositions.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: April 10, 2018
    Assignee: Danisco US Inc.
    Inventors: Nathaniel T. Becker, Robert I. Christensen, Mark S. Gebert, Antti Pekka Vaha-Vahe
  • STABLE GRANULES WITH LOW INTERNAL WATER ACTIVITY
    Publication number: 20180092379
    Abstract: Described are stable, durable granules with active agents, which have consistently low internal water activity, and methods for making such granules. The granules are particularly suitable for inclusion in steam treatment processes, including pelleting and tableting processes and steam processing of feed, without appreciable loss of active agent activity.
    Type: Application
    Filed: March 18, 2016
    Publication date: April 5, 2018
    Applicant: DANISCO US INC.
    Inventors: Nathaniel T. BECKER, Luther WHITE
  • Compositions and methods for clostridial transformation
    Patent number: 9926568
    Abstract: The invention provides compositions and methods for clostridial bacteria that have been engineered to produce and/or to improve efficiency of production of industrial bioproducts.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: March 27, 2018
    Assignee: Danisco US Inc.
    Inventors: Miles C. Scotcher, Derek H. Wells
  • Compositions and methods for producing isoprene
    Patent number: 9909144
    Abstract: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: March 6, 2018
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Marguerite A. Cervin, Gopal K. Chotani, Frank J. Feher, Richard La Duca, Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Aaron S. Puhala, Karl J. Sanford, Fernando Valle, Gregory M. Whited
  • Variant CBH1 cellulases
    Patent number: 9896674
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: February 20, 2018
    Assignee: DANISCO US INC
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • Glycosylation as a stabilizer for phytase
    Patent number: 9894917
    Abstract: The present teachings provide modified enzymes, preferably phytases, which have increased stability, hypothesized to arise from increased glycosylation. The enzymes can be modified to introduce or increase the number of glycosylation sites in the amino acid sequence, or glycosylation can be increased by the use of specific host production methods, or both. The enzymes of the present teachings have an increased stability after treatment at elevated temperature, which can be measured by inactivity reversibility or percent recovery following a treatment such as heating. The enzymes of the present teachings find application for example in food, feed, and feed pelleting.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: February 20, 2018
    Assignee: DANISCO US INC
    Inventors: Mark S. Gebert, Sang-Kyu Lee, Mariliz Johnson, Michael Ward
  • Thermostable carbonic anhydrases and methods of use thereof
    Patent number: 9890374
    Abstract: The present compositions and methods relate to a thermostable carbonic anhydrases, polynucleotides encoding the carbonic anhydrase, and methods of make and/or use thereof. Formulations containing the carbonic anhydrase are suitable for use in extracting carbon dioxide.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: February 13, 2018
    Assignee: DANISCO US INC
    Inventors: Jing Ge, Ling Hua, Ayrookaran J. Poulose
  • FUNGAL STRAINS AND METHODS OF USE
    Publication number: 20180037919
    Abstract: Provided are improved fungal strains and use thereof, wherein the fungal strains are capable of producing an altered level of proteins, enzymes, variants and other substances of interest.
    Type: Application
    Filed: February 9, 2016
    Publication date: February 8, 2018
    Applicant: DANISCO US INC.
    Inventors: Elizabeth A. BODIE, Roman RABINOVICH, Aleksandra VIRAG, Michael WARD, Rochelle NGUYEN, James A. SWEIGARD
  • PROCESS FOR PRODUCTION OF BIO-ALCOHOL
    Publication number: 20180030483
    Abstract: A process of enhanced bio-alcohol production from molasses is provided herein. The process comprises contacting molasses with sodium benzoate, potassium sorbate or a mixture thereof followed by yeast fermentation resulting in at least 6% increased alcohol production. Also included within the scope of the present invention is a process for producing co-product containing reduced glycerol.
    Type: Application
    Filed: March 1, 2016
    Publication date: February 1, 2018
    Applicant: DANISCO US INC.
    Inventors: Gang DUAN, Vipul GOHEL, Jayarama K. SHETTY
  • ENHANCED PROTEIN EXPRESSION
    Publication number: 20180030456
    Abstract: The present invention relates in general to nucleic acids and bacterial cells having a genetic alteration that result in increased expression of a protein of interest and methods of making and using the same.
    Type: Application
    Filed: February 19, 2016
    Publication date: February 1, 2018
    Applicant: DANISCO US INC.
    Inventors: Cristina BONGIORNI, Dennis DE LANGE, George ENGLAND, Marc KOLKMAN, Chris LEEFLANG
  • Polypeptides having beta-mannanase activity and methods of use
    Patent number: 9879245
    Abstract: The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of make and/or use thereof. Formulations containing the beta-mannanase are suitable for use in hydrolyzing lignocellulosic biomass substrates, especially those comprising a measurable level of galactoglucomannan (GGM) and/or glucomannan (GM).
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: January 30, 2018
    Assignee: DANISCO US INC.
    Inventors: Ling Hua, Rosalyn Lau, Steven Le, Zhen Qian, Zheyong Yu
  • ALPHA-GLUCOSIDASE, COMPOSITIONS & METHODS
    Publication number: 20180016563
    Abstract: The present disclosure relates to polypeptides having alpha-glucosidase activity isolated, derived or derivable from Rasamsonia or engineered polypeptides having alpha-glucosidase activity isolated, derived or derivable from Rasamsonia homologs. The present disclosure also pertains to polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, host cells and mutant cells comprising the polynucleotides. The disclosure further pertains to compositions comprising such polypeptides, methods of producing the polypeptides and compositions, as well as methods for using such polypeptides and compositions for industrial applications.
    Type: Application
    Filed: February 25, 2016
    Publication date: January 18, 2018
    Applicant: DANISCO US INC.
    Inventors: Zheyong YU, Zhenghong ZHANG, Jing GE, Zhen QIAN, Guoqing LIU, Zhiyong XIE, Zhongmei TANG
  • Filamentous fungi having an altered viscosity phenotype
    Patent number: 9868958
    Abstract: Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: January 16, 2018
    Assignee: DANISCO US INC.
    Inventors: Elizabeth A. Bodie, Robert James Pratt, II
  • Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
    Patent number: 9862956
    Abstract: The invention is generally directed to modified filamentous fungal host cells comprising one or more nucleic acids encoding one or more polypeptides under the control of one or more promoters that are functional in said cells. Methods of using the modified cells to express one or more polypeptides are also disclosed, including methods of screening cells transformed with one or more expression vectors comprising nucleic acids derived from synthetic or genomic nucleic acids including, cDNAs. Methods of purifying one or more polypeptides or complexes comprising one or more polypeptides expressed in the modified cells, intended for use as substrates in structure/function studies, as therapeutic agents, as diagnostic reagents, or as human or animal vaccines, are also disclosed.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: January 9, 2018
    Assignee: DANISCO US INC.
    Inventors: Mark A. Emalfarb, Peter J. Punt, Cornelia Van Zeijl, Cornelius Van den Hondel, Jan Cornelis Verdoes, Richard P. Burlingame