Abstract: There are provided a needle-equipped syringe barrel and a needle-equipped syringe in which a needle is suitably fixed to a syringe nozzle, and a mold and a method for molding thereof. A metal needle 12 is integrally equipped to a synthetic resin syringe nozzle 113 by integral molding, an area where the needle 12 comes into contact with the nozzle 113 being in a range of 11 to 50 mm2. A needle-equipped syringe barrel 1 in which a metal needle 12 is integrally equipped to a synthetic resin syringe nozzle 113 by integral molding, height of a needle end 122 extruded toward an inner hollow portion thereof opposite to a needle head 121 being in a range of 0.4 to 11 mm.

Abstract: A container or vial (1) for a fluid, the container (1) comprising a casing defining an interior for storage of the fluid and a closure member (2). The closure member (2) comprises a body and at least one resilient projection (7) to seal in a storage condition an outlet of the casing, wherein upon an increase in the pressure of the interior of the container (1) the at least one resilient projection (7) is deflected to accommodate outflow of fluid through the outlet. The pressure in the interior of the container (1) may be increased by displacing the closure member (2) into the container (1) or by displacing some other element such as a bung (61, 82) into the container (1). The container (1) and closure member (2) may be used in a dispenser (90) and the closure element may be used in a valve (110).

Abstract: A syringe-type cell handling device for storing and subsequently transplanting, into a living body, cells harvested from a living body or cells obtained by culturing harvested cells. The syringe-type cell handling device includes a vessel having a closed mouth and being at least partially composed of a main body, and a plunger that is slidably insertable into the main body such that the handling medium can be transplanted into a living body by applying a pushing force to the plunger. At least a part of the device that contacts the fluid handling medium, when the vessel holds the handling medium, is a gas permeable region for passing a quantity of gas necessary for survival of the cells. It is preferable that at least a part of the storage vessel inner wall in contact with the cells is formed from a cell non-adhesive material.

Abstract: A syringe device includes a syringe tube having a distal end with a passageway in fluid communication with a cavity thereof. A plunger rod slidingly and sealingly engages within the cavity of the syringe tube. The plunger rod includes at least one aperture in fluid communication with a hollow interior of the plunger rod. A plunger tip is engaged with a distal end of the plunger rod and interacts with an inner surface of the side wall of the syringe tube to separate the cavity into first and second areas. The at least one aperture fluidly connects the hollow interior of the plunger rod and the first area of the syringe tube cavity, such that the generally hollow plunger rod interior allows air to move between an outside of the syringe device and the first area of the cavity during sliding movement of the plunger rod within the syringe tube.

Abstract: A piston stopper for a medicine injector, wherein the stopper has a stopper body with a mesh section and at least one sealing element positioned at least partly around the circumference of the stopper body, wherein at least one of the sealing element and mesh section is connected to the stopper body in a material bond. A method for manufacturing such a piston stopper is encompassed.

Abstract: An improved, very wieldy anesthetic syringe that allows for precise and repeated injection has a first hydraulic chamber behind a feed piston and a second hydraulic chamber behind the first hydraulic chamber, the hydraulic chambers being connected so as to allow for regulation of the flow resistance. A special receiver for cannulae that have been specifically developed for use with the proposed syringe is also provided.

Abstract: A syringe for parenteral injection of a semi-solid formulation. The syringe includes a hollow element forming a reservoir for the semi-solid product to be injected between a plunger and a needle hub urged in contact with the reservoir end. The plunger comes into direct contact with the hub when the dose contained in the reservoir-forming element has been injected. The element forming a reservoir and the needle are maintained mutually interlocked at the hub through a mount or case receiving the element forming a reservoir.

Abstract: A plunger for a retracting needle syringe includes a hollow elongate body portion having a proximal end, a distal end, and a side wall therebetween defining a cavity. The distal end includes a distal wall having an inside surface and an outside surface. A stopper, at the distal end of the body portion, includes a peripheral portion performing a seal with the inside surface of a syringe barrel and at least one radial element extending from about a center of the outside surface of the distal wall to the peripheral portion. The distal end of the body portion includes at least one primary chamfer in the cavity at an intersection of the inside surface of the distal wall and the side wall. The chamfer is positioned under the at least one radial element for supporting the distal wall and the radial element when a hollow sleeve in the syringe barrel cuts through the end wall plunger. A secondary, smaller chamfer on each side of the primary chamfer is also provided.

Abstract: Present proposals for liquid-medium carriers for glass particles comprising pharmaceutical compositions have had problems associated with aggregation of the glass particles. This has been previously solved by matching the density of the particles and a liquid in which they are suspended. However, though this greatly constrains the choice of liquid carrier that can be used. An alternative solution to this problem has been found. By adding just a small amount of liquid (2) to the particles (1), a flowable mixture is formed of a creamy or paste-like consistency. Providing too much liquid (2) is not present, the particles (1) do not separate out and so the choice of liquid carriers available for use in compositions of this type is greatly increased.

Abstract: A process for creating a stop surface on a plunger rod of a syringe is disclosed. The process includes the step of providing a preformed or molded plunger rod, and the step of forming a radially-extending deformation on the molded plunger rod. The presently disclosed in-line process allows for the use of a single molding rod to form plunger rods having one or more selectively located stop positions.

Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.

Abstract: A device for administering metered doses of an injectable product, including a housing, a drive member with a plunger, a drive button which, when displaced, moves the drive member relative to the housing, and at least one delaying member, which can be moved from a first position into a second position by displacing the drive button relative to the drive member in the longitudinal direction of the device, the drive member remaining stationary relative to the housing, whereby the at least one delaying member establishes a contact with the drive member in the first or second position so that when the drive button is displaced, the drive member can be moved in the forward direction before or after the at least one delaying member is moved relative to the drive member.

Abstract: A pre-filled syringe including a barrel 1, a base end gasket 4 which is fluid-tightly slidable in the barrel 1, a front end gasket 8 which is fluid-tightly slidable in the barrel 1, and a nozzle part 2 provided in a front end of the barrel 1, wherein the nozzle part 2 includes a front end gasket accommodation part 23 which is capable of accommodating the front end gasket 8, and liquid flow passages 21 extending in an axial direction in an inner periphery wall, through which a liquid medicine can pass when the front end gasket 23 is accommodated in the front end gasket accommodation part 23, and a sectional area of a front end of the liquid flow passages 21 is smaller than a sectional area of a base end.

Abstract: Exemplary embodiments provide subcutaneous implantation tools and methods of implanting a subcutaneous micro-device using the same. Exemplary embodiments provide subcutaneous implantation tools including a syringe body, a dissection body, and a delivery assembly. Additional exemplary embodiments provide methods of implanting a subcutaneous micro-device, including inserting the dissection body of the tool described by the exemplary embodiments into an implantation site, where the dissection body includes a micro-device, and delivering the micro-device.

Abstract: Dispenser (1) for adhesive Newtonian fluid, comprising: a syringe (5) containing the adhesive fluid; a plunger (23) for pushing the adhesive fluid out of the outlet spout of the syringe (5); an inlet (27) for a propellant gas; means (28) for mixing the adhesive fluid coming out from the syringe (5) and the propellant gas coming from said inlet (27) in order to obtain a mixture deliverable by atomization on a surface, said means (28) for mixing being shaped in such a way that the mixing of the adhesive fluid and the propellant gas takes place in proximity to an open end (14a) of a cannula or catheter (14) of the dispenser (1).

Abstract: A fluid introduction system includes an introducer configured to create a pressure of at least 69 kPa within a spine, and an operator configured to actuate the introducer to introduce fluid into the spine according to a predetermined fluid introduction profile. The system can include a computer readable medium having code for receiving fluid introduction data indicative of a fluid introduction parameter, and for receiving response data indicative of a response of the patient at a time related to a time of the fluid introduction data. A method for introducing fluid includes positioning a first introducer in a first portion of a spine, positioning a second introducer in a second, different portion of the spine and, without removing the first and second introducers, introducing fluid into the first portion of the spine with the first introducer and introducing fluid into the second portion of the spine with the second introducer.

Abstract: A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient.

Abstract: The present invention relates to a medicament delivery device such as a pen type injector used to expel medicament from a medicament cartridge under the action of a lead screw. The medicament cartridge typically comprises a cylinder having a displaceable piston at one end displacement causing medicament contained within the cartridge to be expelled. It is of advantage to know when the plunger contacts the displaceable piston since no delivery of medicament can occur before this point.

Abstract: A medication dispensing apparatus having a gear set (64) to provide a mechanical advantage to the plunging of the apparatus plunger (66). The gear set (64) has a first pinion (114) in meshed engagement with a rack of the plunger (102), and a second pinion (126) in meshed engagement with a rack of a drive member (80) of the apparatus. The gear set (64) operatively interconnects the plunger (66) and the drive member (62) such that after the plunger (66) is moved relative to the housing in a proximal direction to prepare the apparatus for injection, the plunger (66), when manually pushed back toward the housing, causes the drive member (62) to advance in a distal direction to force medication through an outlet, typically provided with an injection needle, at the distal end of the apparatus.

Abstract: An injection device for injecting selectable amounts of a substance includes an activating mechanism including an axially moveable operating button which can rotated in a resting position only, a tubular drive element non-rotatably connected to the operating button, an axially fixed and non-rotatable guiding element, and an axially moveable driven member held non-rotatably in the device. A rotational grid is operationally between rotatable and non-rotatable components of the injection device such that the operating button can be moved two rotational directions when in the resting position whereby a selected amount of the substance to be injected can be selectively varied. For example, a dosage inadvertently selected too large by rotating the operating button too far in one direction can, in accordance with the present invention, be reduced by rotating the operating button in the opposite direction.

Abstract: An intravenous catheter introducing device includes a needle hub slidably inserted into a barrel and holding a needle cannula, a biasing member disposed to bias the needle hub to a rear position so as to retract the needle cannula in the barrel, and an easy release unit including an engaging wall segment which is attached to an outer surface of the barrel, two flexible squeezed wall segments which extend from the engaging wall segment and which is squeezable so as to move two latch members to steer clear of a retained end of the needle hub through an access hole in the barrel, thereby permitting the biasing member to bias the needle hub towards the rear position.

Abstract: A syringe and detachable needle assembly having reduced dead space features includes an elongate syringe barrel having open distal end including a collar and a distally facing annular surface projecting inwardly from the collar. A needle assembly includes a hub having a proximally facing annular surface and an outwardly projecting annular sealing ring positioned distally from the surface. The needle assembly also includes a cannula having a lumen therethrough connected to the distal end of the hub. Structure is provided for engaging the hub to the barrel resulting in the annular surface of the barrel contacting the annular surface of the hub to form a primary seal between said barrel and said hub and the annular sealing ring contacting the collar to form a secondary seal between the barrel and the hub.

Abstract: A rubber syringe piston in a generally cylindrical shape slidably mounted in a syringe barrel. The piston has a circular depression at an intermediate part thereof. R1 is smaller than R2 where sliding surfaces are disposed on the both sides of the circular depression and R1 is a diameter of the sliding surface on the leading end side of the piston and R2 is a diameter of the sliding surface on the rear end side of the piston, L1 is equivalent to or larger than L2 in the case in which L1 is a length of the sliding surface on the leading end side of the piston and L2 is a length of the sliding surface on the rear end side of the piston, and r is equivalent to or larger than 0.7 mm where r is a radius of curvature of a corner portion on the leading end side of the piston.

Abstract: An angiographic injector system and a method of controllably delivering medical fluid to a patient from an angiographic injector system are disclosed. A multiple processor control system is used to actively control the injection process and to monitor sensed functions of the system. The multiple processors provide dual redundancy safety circuits for critical control functions such as syringe motor drive speed and current. A motor/servo-amplifier nested control function is also disclosed. A unique method and apparatus are disclosed for establishing injection parameter default values just prior to an injection procedure that are based on physiological values of the patient to be treated. The injector system uses an interactive display panel that presents sequenced set-up screens to the user and which enables the user to select injection procedures, parameters and other modes of operation directly through the interactive panel.

Abstract: An injection device for injecting a fluid into an object, the injection device including a plunger assembly for operative engagement with a syringe adapted to contain the fluid and permit ejection of the fluid therefrom via a syringe outlet, the plunger assembly being displaceable in a first direction which causes at least some of the fluid contained in the syringe to be ejected from the syringe via the syringe outlet and an inadvertent fluid ejection prevention assembly coupled to the plunger assembly for preventing ejection of fluid from the syringe in situations where the syringe outlet is neither in operative engagement with a vial adaptor suitable for providing fluid communication with the interior of a vial nor in fluid communication with an injection site within the object.

Abstract: A system for delivering multiple implants into lung passageways is disclosed. The system comprises a catheter configured to receive and store a plurality of expandable implants, and an actuatable delivery tool coupled to the proximal end of the catheter. The system expels an implant of the plurality of implants with each actuation of the delivery tool. The delivery tool comprises a plunger element which extends through the catheter from the proximal to the distal end and allows the delivery tool to mechanically communicate with the implants. In one embodiment, the system comprises a spring-loaded slidable element, and a user compresses the slidable element to actuate the delivery tool. In another embodiment, the system comprises a rotation rod, and the user moves the rotation rod in a distal direction to actuate the delivery tool.

Abstract: A syringe plunger has a hole is arranged in its plunger central axis, with a diaphragm arranged in the hole. The thickness of the diaphragm in the hole is from 0.01 mm to 0.5 mm. A manufacturing method of a syringe plunger includes the steps of: adding pigment into medical rubber and stirring uniformly; each of a fixed die and a movable die of a medical rubber syringe die being embedded with an impacting and penetrating needle, when molding and die closing, space between the impacting and penetrating needles of the fixed die and the movable die being 0.01 mm to 0.5 mm; demolding said molded medical rubber plunger.

Abstract: A syringe in which multiple sealing flanges are provided for sequential movement during use, to reduce sticking of the flange during use and the consequent jerking of the plunger stopper. In an embodiment longitudinally sequential flanges are linked by a flexible tube connection.

Abstract: A syringe and needle assembly includes a needle that extends through the barrel of the syringe and is attached to a proximal portion of the syringe. The distal end of the needle extends through a sleeve attached to the distal end of the syringe. The proximal end of the needle includes a spring which biases the needle proximally, so that the distal tip of the needle is normally retracted within the sleeve.

Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.

Abstract: A syringe includes a needle assembly at least partially secured within a barrel of the syringe, the needle assembly including a needle stem, a resilient member biasing the needle stem toward a proximal end opening of the barrel, a needle holder connectable to the needle stem during assembly of the syringe and that is further securable to a needle, and a cap that is dimensioned to surround the needle secured to the needle holder and a portion of the needle holder during assembly of the needle holder with the needle stem.

Abstract: A prefilled medical syringe includes a syringe barrel. A syringe plunger is disposed in the barrel and displaceable by means of a plunger rod. An end plug closes off a cannula side of the syringe barrel. The plug is provided with a through-channel closed off by a membrane. A finger support is disposed at the end of the syringe barrel opposite the end plug and provided with a through-opening for the plunger rod. A thread system cooperates with the plunger rod and the finger support. The thread system includes a thread sleeve detachably connected with the finger support. The thread sleeve is provided with an inner thread that cooperates with an outer thread on the plunger rod.

Abstract: Medical devices comprising a syringe barrel and a two-piece plunger rod are provided. According to one or more embodiments, the two-piece plunger rod includes a distal portion and proximal portion slidably mounted to the distal portion. The distal and proximal portions include a tab and plurality of grooves which engage to adjust the overall length of the plunger rod to a plurality of locked lengths. The locked lengths of the plunger rod permit varying amount of fluid to be expelled from the barrel.

Abstract: The present invention relates to a volume-adjustable micro-injection device. The device includes a base structure having a syringe positioning structure and a grip, in which the syringe positioning structure can flexibly accommodate injection syringes with different volumes; a holding structure capable of flexibly adjusting an injection angle of syringe content for easier operation; a qualitative controller capable of accurately controlling injection volume; a pressure pushing structure to hold and push a plunger; an injection controller interlinked with the qualitative controller and the pressure pushing structure; and an eject structure facilitating simple operation and easy replacement of injection syringes.

Abstract: A flexible piston rod includes a piston and a row of elements, the top surface of one element being connected to the bottom surface of an adjacent element by a hinge that allows the two adjacent elements to pivot from a first position, where a portion of the top surface of one element abuts a corresponding portion of the bottom surface of the adjacent element and corresponding to a rectilinear, relatively stiff configuration of the piston rod, to a second position wherein the top surface of one element is spaced from the bottom surface of the adjacent element and corresponding to a curved configuration of the piston rod. Each element has cylindrical surface portions incorporating a thread for meshing with a corresponding thread of an actuator for displacing the piston rod longitudinally.

Abstract: A method of administering liquid medicine such as epinephrine to a patient includes administering a first dose followed by administering an optional second dose is described herein. Also described herein are devices useful for carrying out the methods described and kits containing these devices.

Abstract: The filling of a syringe can be performed at a faster rate using a filling sequence which expels air from the fill tube before filling the syringe. A similar method is used when changing contrast containers during a filling sequence to ensure that all the air is expelled from the fill tube before filling resumes with the new contrast container. Additionally, by including a contrast container holder that is affixed to an injector head and holds the container near the syringe tip, the filling sequence can be accomplished without requiring the operator to hold the contrast container during the sequence.

Abstract: A device for expelling a fluid through a needle mounted on a hub includes an elongated luer member that has a distal portion dimensioned to engage the needle hub to provide fluid communication between the luer member and the needle. An adapter anchors the luer member within the device. Slidingly mounted on the adapter is a cylindrical-shaped inverted plunger that is movable thereon between an advanced position and a withdrawn position. A needle guard is biased by a biasing member to extend distally from the luer member when the plunger is in the advanced position. The guard is selectively engageable with the plunger to be retracted to expose the distal portion of the luer member for fluid engagement with the needle hub when the plunger is moved to the withdrawn position.

Abstract: A disposable syringe after one time usage includes an outer tube having an inner teeth set formed on the inner wall of the outer tube and an inner tube having an outer teeth set formed on the outer wall of the inner tube and a safety guide. The inner teeth set of the outer tube meshes with the outer teeth set of the inner tube. The single direction design of the teeth sets allows the outer tube to be pulled away from the inner tube, but not to be pushed back. The pulling force of the outer tube will pull the safety guide to form a damaged groove and the outer tube is adapted to enclose a needle so that the needle is not exposed outwardly, which prevents the needle from poking people accidentally. The syringe is unable to be reused.

Abstract: A casing may be configured to envelop at least a portion of a plunger arm attached to a plunger head located in a reservoir. A plunger head moveable in a reservoir may have a front portion comprising a first material compatible with fluidic media in an interior volume of the reservoir. A seal member having a first end and a second end that taper to a mid-portion may be positioned between a reservoir and a plunger head. A bias member may be configured to force a plunger arm operatively connected to a plunger head against a drive member to operatively engage the plunger arm to the drive member. A plunger head moveable in a reservoir may have a first ridge, a second ridge, a seal member adjacent at least one of the ridges, and protrusions arranged around at least one of the ridges.

Abstract: Injection device comprising a tubular elongated main body, a needle shield slidably arranged in said main body, a needle shield link slidably connected to said needle shield, a enclosure containing medicament arranged in said main body, a needle connected to said enclosure, a plunger operatively arranged to said enclosure for ejecting said medicament through said needle and arranged on its upper part with a number of outwardly extending stop members, spring means arranged to said plunger for operating said plunger, a dose activating means, a needle shield spring surrounding the needle shield link.

Abstract: The invention is an apparatus comprising of a syringe, a plunger and a circuit for the purpose of activating a light source to illuminate a target area for application of the contents of the syringe in low-light or no-light situations.

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: Syringe having a plunger, a barrel and a restrictor mechanism between the shaft of the plunger and the barrel and including a first part engaged with the barrel for limiting movement of the first part with respect to the barrel in a first direction, and a second part. The restrictor mechanism and/or plunger shaft carries a formation for limiting movement of the restrictor mechanism with respect to the plunger in the first direction. The restrictor mechanism as a further member which restricts movement of the restrictor mechanism with respect to the barrel or plunger shaft in a second direction. A latch member prevents he further member from restricting movement of the restrictor mechanism with respect to the barrel or plunger shaft in the second direction until a predetermined point in an operation cycle of the syringe.

Abstract: Kits, apparatus, devices and methods for treating varicose veins caused by an incompetent venous junction (e.g., the saphenofemoral and/or saphenopopliteal junctions) are disclosed. The kits may include a sheath, a vein closure device, and an injection device. Alternatively, a vein closure device may include an integral injection channel and injection device. Methods may include injecting a vein with a sclerosing agent through a needle that extends in a direction that is not aligned with a longitudinal axis of a sheath or shaft.

Abstract: A tubular body has a vent hole VA and a suction opening. The piston body is in a state in which the inside of the tubular body in an enclosed space is divided into a front chamber and a rear chamber. The piston body includes piston portion which reciprocate in a position on its front end side from the suction opening, a shaft portion which supports this piston portion on its front end side and whose external diameter is smaller than the internal diameter of the tubular body and a pressing portion provided on a rear end side of this shaft portion. A vent passage is formed in the shaft portion so as to couple a vent hole VB of this pressing portion and a vent hole VC on its front end side of the shaft portion. Further, a spring is provided to return the pressed pressing portion to its original position.

Abstract: An apparatus includes a tubular member and a spherical piston disposed within a lumen defined by the tubular member. The tubular member includes a distal end portion and a central portion. The distal end portion is configured to be coupled to a needle. At least the central portion of the tubular member is curved. The spherical piston is movably disposed with the lumen such that the lumen is divided into a first portion and a second portion. The first portion of the lumen configured to contain a medicament.

Abstract: A syringe comprises a barrel with a plunger in slidable and sealing engagement therein, and a needle attached to one end of the barrel. The barrel has an aspiration device in the form of manually-operable resilient portions, which can be operated to cause a pressure differential in the barrel, the pressure differential then being used to perform aspiration. The resilient portions are preferably formed by localised reductions of wall thickness in the external surface of the barrel.

Abstract: A injection system having a syringe body which defines a pumping chamber. A syringe plunger is located in the pumping chamber and is adapted for reciprocal motion within the pumping chamber. The syringe plunger includes a capture member projecting outwardly in a proximal direction. An actuating shaft is coupled to the syringe plunger and is movable through the syringe body to control movement of the syringe plunger. The capture member is adapted to flex radially outwardly when contacted by the actuating shaft to form a releasable engagement with the actuating shaft when the actuating shaft and the capture member are in an engagement position. A release actuator is disposed proximal to the syringe body, and the capture member releases the actuating shaft upon engagement with the release actuator.

Abstract: A syringe for use with a carpule and needle is provided. The syringe comprises: (i) a holder for accepting the carpule, the holder comprising at least two linearly disposed first mating members; (ii) a plunger for engagement with the holder; and (iii) a shell for slidably housing the holder, the shell having a distal aperture and a proximal aperture, with a bore therebetween, the shell comprising at least one integral biased member proximate to the proximal aperture, the biased member having a second mating member proximate to a distal end, for mating with the first mating member, such that in a first position, the needle is housed within the shell and in a second position, the needle extends at least partially from the shell.