Abstract: The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies.

Abstract: A risk analysis system and method are provided. The system includes an analyzer for analyzing database instances by executing a query on each database instance and selecting a cutoff value. The analyzer also discards the sets of uncertainty data that yield query-result values below the cutoff value and retains the database instances that yield query-result values above the cutoff value as elite sets. The system also includes a cloner to replicate the elite sets, and a sampler to modify the elite sets so that each elite set is mutually statistically independent while still yielding query-result values above the cutoff value.

Abstract: A reference voltage generation circuit includes a driving control unit configured to output an enable signal during a first time period in response to a power-on reset (POR) signal, a reference voltage generation unit configured to have an initial operation determined in response to the enable signal and to output a reference voltage maintained at a constant voltage level after the first time period, and a reference voltage control unit configured to fix the voltage level of the reference voltage to a first voltage upon a voltage level of the reference voltage being increased to at least a set voltage level.

Abstract: A method and computer-readable medium for generating an activity stream is provided. The activity stream includes a ranked set of objects that are presented to one or more users. The ranking of objects is updated to reflect events associated with objects.

Abstract: A method for fabricating a semiconductor device includes providing a substrate including cell regions and peripheral regions; selectively forming a gate conductive layer over the substrate in the peripheral regions, forming a sealing layer over the substrate with the gate conductive layer formed thereon, forming an insulation layer over the sealing layer to cover the substrate with the gate conductive layer formed on the substrate, planarizing the insulation layer to expose the sealing layer formed over the gate conductive layer, and forming a plurality of plugs in the cell regions, the plurality of the plugs penetrating the insulation layer and the sealing layer.

Abstract: The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFN?”) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFN? protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFN? subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFN? related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.

Abstract: A spray head (1) with a nozzle insert (2) for atomizing a fluid, which tends to gum up or harden, from a reservoir, wherein the nozzle insert (2) is substantially designed as a hollow cylinder (3) that is open on one side and has, on the other side, a nozzle opening (4) towards the outside, and the nozzle insert (2) is connected to a nozzle insert receptacle (5), which has a channel (6) for the fluid, wherein the channel (6) corresponds to the nozzle opening (4). The nozzle insert (2) consists of an elastic material (7) and, in this manner, is connected to the nozzle insert receptacle (5) so that an external, free section (8) of the nozzle insert (2) along with the nozzle opening (4) is at least partially manually compressible and/or is designed to be manually bendable from its standby position (R), whereby hardened resin residue (12) can be removed from the nozzle opening (4).

Abstract: A method of servicing requests for information at a server includes receiving a request for information from a client device, and determining a number of attempts of the request made by the client device. Both the client device and the server may count the number of attempts for each request. When the number of attempts is greater than a threshold, the method includes servicing the request and sending the information to the client device. When the number of attempts is not greater than the threshold, the method includes sending a service unavailable message to the client device. A retry-after delay may be calculated by the server according to a predicted time for the server to exit the overloaded state and included in the service unavailable message. The predicted time may take into account both requests currently being serviced and requests that have been scheduled to be serviced in the future.

Abstract: A communication system electromagnetically communicates beyond the electromagnetic barrier created by a physical barrier. First pre-existing electrical AC power distributing infrastructure extends on one side of the physical barrier and has electrical conductors and AC outlets. At least one first communication subsystem is located at the one side of the physical barrier and is connected to the electrical conductors. At least one second communication subsystem is located at an opposite side from the first side of the physical barrier. The first and second communication subsystems each have a first handheld transceiver radio, a second transceiver radio, a radio-to-local-area-network converter, and a power line Ethernet adapter. At least one electrical conductor extends the electrical power distributing infrastructure on the one side to the power line Ethernet adapter of the second communication subsystem on the opposite side of the physical barrier.

Abstract: A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (BM) differentiation into dendritic cells (DC) during in vitro cultivation with the cytokine GM-CSF by addition of antisera to an 82 kd BM cell surface protein generating cultivatable dendritic progenitor cells (DP). Genes, methods for preparing them as well as early DP have been provided. Potential uses/advantages lie in the study of BM differentiation and innate immunity due to stimulatory/inhibitory DC, contribution of BM and DP to inflammation during infection and carcinogenesis, tumor promotion/regression, identification of BM-derived blood cells, T-cell activation/regulation/tolerance and inflammation.

Abstract: A semiconductor memory device comprises memory blocks having a plurality of memory cells coupled to a plurality of bit lines, a first latch group coupled to a sense node and configured to store data to be programmed into memory cells, where the memory cells are coupled to the bit lines and the sense node is coupled to at least one of the bit lines, a second latch group coupled to the sense node and configured to receive data of the first latch group, and a sense node voltage control circuit configured to control a voltage of the sense node according to data stored in the first latch group.

Abstract: A seal structure is provided for an energy storage device. The seal structure includes a first sealing glass composition and a second sealing glass composition joining an ion-conducting first ceramic to an electrically insulating second ceramic. The first sealing glass composition includes less than or equal to about 20 weight percent silica based on the weight of the first sealing glass composition. The second sealing glass composition includes greater than or equal to about 40 weight percent silica based on the weight of the second sealing glass composition. A method for making the seal structure is provided. An article comprising the seal structure is also provided.

Abstract: An impedance calibration mode control circuit includes: a first signal generating unit configured to generate a first calibration control signal in response to a ZQ calibration command received after a power-up operation; and a second signal generating unit configured to generate a second calibration control signal during a refresh operation of a semiconductor device.

Abstract: Methods and apparatuses, including computer program products, are described for transparent recovery of transport connections. The method includes collecting a state associated with a first connection between a first server and a remote server via a first network socket and transmitting the state from a first networking module to a second networking module. The method includes storing the state, opening a second network socket based on failure of the first networking module, intercepting outbound packets associated with a request to initiate a second connection between the first server and the remote server via the second socket, modifying the intercepted packets based on the state, and transmitting the modified packets to the remote server to elicit an acknowledgement to maintain the first connection. The method includes receiving packets associated with the acknowledgment from the remote server, and modifying the received packets to acknowledge the request to initiate the second connection.

Abstract: The invention in one variation is a pressure vessel having a pair of hemispheres with a wall and a circular edge, a pair of sealing elements, and an intervening mounting plate with circular groove on both sides of the plate. The hemispheres are mounted on opposite sides of the plate. Each groove has an sealing element and the circular edge. A seal is formed between the plate and a hemisphere when the hemisphere is pressed against the sealing element. Pressure can be generated by creating a partial vacuum in the sealed hemispheres or by using clamps. When exposed to higher pressures, such as when the vessel is used underwater, the pressure on the hemispheres is conveyed to the sealing element forming an even tighter seal. The vessel has interface connections that enable communication to and from devices mounted inside. The vessels are modular and can be ganged to provide redundancy or different functions.

Abstract: The present invention relates to a process of treating a hard surface with a composition comprising polyalkoxylate trisiloxane. More specifically, it relates to a process of treating an horizontal hard surface, wherein a composition comprising polyalkoxylate trisiloxane is applied onto said hard surface.

Abstract: A semiconductor memory device includes a clock synchronizing unit for receiving a first power voltage through a first power voltage terminal, and an additional power voltage providing unit for additionally providing a second power voltage to the first power voltage terminal for a predetermined period after leaving a power down mode.

Abstract: The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4 are as described herein.

Abstract: A data transfer circuit includes a first driver configured to drive a first line with data, a pattern alteration unit configured to change a pattern of the data transferred through the first line and produce a pattern-changed data, a second driver configured to drive a second line with the pattern-changed data; and a pattern restoration unit configured to receive the pattern-changed data transferred through the second line and restore the pattern of the data before the pattern change.

Abstract: Within a high level modeling system (HLMS) comprising a processor and a memory, a method can include executing a system template comprising a plurality of modules of an electronic system, wherein each module represents a hardware component of the electronic system and is specified in the form of an extendable, higher order function, and extending, during runtime, a first module of the plurality of modules with a first extension by binding, via the processor, the first extension to the first module. The plurality of modules comprising the first extension to the first module can be stored within the memory.