Abstract: Disclosed herein is a catheter pump that includes an expandable cannula and an impeller system. The expandable cannula defines a blood flow channel and includes an impeller blade zone, an inlet zone, and an outlet zone. The catheter pump further includes an impeller system including an impeller body, the impeller system movable relative to the expandable cannula along a longitudinal axis of the catheter pump. The catheter pump is selectively transitionable between a separated configuration in which the impeller body is axially spaced from the expandable cannula along the longitudinal axis, and an operational configuration in which the impeller body is positioned within the impeller blade zone of the expandable cannula.
Type:
Grant
Filed:
April 22, 2019
Date of Patent:
May 17, 2022
Assignee:
TC1 LLC
Inventors:
Alexander King, David Panus, Tracee Eidenschink, John Pocrnich, Kevin Griffin
Abstract: A local stimulation method of a predetermined region of brain tissue, the brain tissue including at least GABAergic neuron type. The method includes at least one activation step of a set of bipolar electrodes, according to a predetermined electric intensity and a predetermined biphasic pulse frequency, delivering a predetermined electric field. The predetermined electric field induces an activation of the GABAergic type neurons and a virtual absence of activation of other types of neurons.
Type:
Grant
Filed:
March 31, 2017
Date of Patent:
May 17, 2022
Assignees:
UNIVERSITE DE RENNES 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Abstract: A proton exchange membrane includes a porous structural framework and a boron-based acid group bonded to the porous structural framework. The porous structural framework may be formed of an amorphous or crystalline inorganic material and/or a synthetic or natural polymer. The boron-based acid group may be a tetravalent boric acid derivative, such as a cyclic boric acid derivative, borospiranic acid, or a borospiranic acid derivative. The boron-based acid group may be the reaction product of boric acid or a boric acid derivative and a poly-hydroxy compound.
Abstract: A securing assembly for connecting a drive assembly to a driven assembly of a catheter pump includes a motor housing, a flow diverter housing, and a flow diverter positioned within the flow diverter housing, wherein one of the flow diverter or the flow diverter housing includes a securement device. The securing assembly also includes a cap coupled between the motor housing and the flow diverter housing. The cap includes a central opening and a locking recess extending circumferentially about the central opening. Insertion of the flow diverter into the central opening causes securement device to engage the locking recess.
Type:
Grant
Filed:
January 31, 2020
Date of Patent:
May 17, 2022
Assignee:
TC1 LLC
Inventors:
Paul F. Muller, Keif M. Fitzgerald, Richard L. Keenan
Abstract: Disclosed herein is an inflow cannula for an implantable blood pump assembly. The inflow cannula includes a tubular body that extends from a proximal end to a distal end. The tubular body includes a proximal portion adapted for connection to a pump housing, and a distal portion adapted for positioning within an opening formed in a heart. The inflow cannula further includes an expandable sleeve coupled to an exterior surface of the distal portion. The sleeve has a first portion coupled to the distal portion of the tubular body, and a second portion extending from the distal end of the tubular body. The second portion is deployable from a first, stored configuration to a second, deployed configuration in which the second portion expands radially to engage and conform to an endocardial surface of the heart.
Type:
Grant
Filed:
January 16, 2020
Date of Patent:
May 17, 2022
Assignee:
TC1 LLC
Inventors:
Rachel Keen, Steve Franklin, Tracee Eidenschink, Ted Dale, Gary Erzberger, Kristopher Vietmeier, Julien Duhamel, Francheska Torres
Abstract: An exercise machine creates a simulated continuous resisted climbing motion. The machine includes a floor- or ground-contacting base frame and two or more substantially vertically oriented uprights, wherein at least one upright is rigidly connected to the base frame. The machine further includes two handles and two foot pedals, each handle and each foot pedal being movably engaged with an upright for linear reciprocating motion along the upright. The handles and foot pedals are interconnected so that they move concurrently. An adjustable resistance mechanism may be operatively connected to the interconnection of the handles and foot pedals to provide adjustable resistance for the simulated continuous climbing motion.
Abstract: A particle detector includes at least one resonant cavity partially formed at least by a first reflector, a second reflector disposed at a distance from the first reflector and a channel located between the first and second reflectors, the channel being intended to receive at least one fluid comprising particles and to receive at least one light radiation; and at least one detection system having at least one photodetector. The particle detector is configured so that a portion of the light radiation present in the channel escapes from the cavity throughout the second reflector and reaches the detection system, thereby enabling the at least one photodetector to detect leakage of the cavity. The second reflector is a photonic crystal membranes PCM based reflector.
Type:
Application
Filed:
December 23, 2019
Publication date:
May 12, 2022
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CPE LYON, ECOLE CENTRALE DE LYON, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
Inventors:
Gabriel JOBERT, Salim BOUTAMI, Maryse FOURNIER, Christian SEASSAL
Abstract: Method and systems control a rotational speed of a blood pump during ventricular diastole. A method includes controlling a blood pump in accordance with a first segment operational mode. A controller monitors the blood flow rate through the blood pump. The controller determines, based on the blood flow rate, whether continued controlling of the blood pump per the first segment operational mode would result in the blood flow rate through the blood pump being less than a target minimum blood flow rate. In response to a determination that continued controlling of the blood pump per the first segment operational mode would result in the blood flow rate through the blood pump being less than the target minimum blood flow rate, the controller controls the rotational speed of the blood pump so that the blood flow rate through the blood pump is approximate to the target minimum blood flow rate.
Abstract: Novel and useful electronic and magnetic control of several quantum structures that provide various control functions. An electric field provides control and is created by a voltage applied to a control terminal. Alternatively, an inductor or resonator provides control. An electric field functions as the main control and an auxiliary magnetic field provides additional control on the control gate. The magnetic field is used to control different aspects of the quantum structure. The magnetic field impacts the spin of the electron by tending to align to the magnetic field. The Bloch sphere is a geometrical representation of the state of a two-level quantum system and defined by a vector in x, y, z spherical coordinates.
Type:
Grant
Filed:
June 19, 2019
Date of Patent:
May 10, 2022
Assignee:
Equal1.Labs Inc.
Inventors:
Dirk Robert Walter Leipold, George Adrian Maxim, Michael Albert Asker
Abstract: An exercise machine creates a simulated continuous resisted climbing motion. The machine includes a floor- or ground-contacting base frame and two or more substantially vertically oriented uprights, wherein at least one upright is rigidly connected to the base frame. The machine further includes two handles and two foot pedals, each handle and each foot pedal being movably engaged with an upright for linear reciprocating motion along the upright. The handles and foot pedals are interconnected so that they move concurrently. An adjustable resistance mechanism may be operatively connected to the interconnection of the handles and foot pedals to provide adjustable resistance for the simulated continuous climbing motion.
Abstract: Novel and useful quantum structures having a continuous well with control gates that control a local depletion region to form quantum dots. Local depleted well tunneling is used to control quantum operations to implement quantum computing circuits. Qubits are realized by modulating gate potential to control tunneling through local depleted region between two or more sections of the well. Complex structures with a higher number of qdots per continuous well and a larger number of wells are fabricated. Both planar and 3D FinFET semiconductor processes are used to build well to gate and well to well tunneling quantum structures. Combining a number of elementary quantum structure, a quantum computing machine is realized. An interface device provides an interface between classic circuitry and quantum circuitry by permitting tunneling of a single quantum particle from the classic side to the quantum side of the device.
Type:
Grant
Filed:
June 19, 2019
Date of Patent:
May 10, 2022
Assignee:
Equal1.Labs Inc.
Inventors:
Dirk Robert Walter Leipold, George Adrian Maxim, Michael Albert Asker
Abstract: A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.
Abstract: An oil control valve for a cam phaser of an internal combustion engine, the oil control valve including a valve housing, including a first operating connection, a second operating connection, a supply connection, and a tank drain connection configured to drain a hydraulic fluid; a piston assembly, including a piston, a hollow check valve tube, a first check valve and a second check valve configured to provide cam torque recirculation, wherein the piston assembly is arranged in the housing axially displaceable by an actuator, wherein a control chamber is arranged within the piston between the first check valve and the second check valve and wherein a check valve compression spring which closes the first check valve and the second check valve is arranged within the piston between the first check valve and the second check valve.
Abstract: A novel and useful quantum computing machine architecture that includes a classic computing core as well as a quantum computing core. A programmable pattern generator executes sequences of instructions that control the quantum core. In accordance with the sequences, a pulse generator functions to generate the control signals that are input to the quantum core to perform quantum operations. A partial readout of the quantum state in the quantum core is generated that is subsequently re-injected back into the quantum core to extend decoherence time. Access gates control movement of quantum particles in the quantum core. Errors are corrected from the partial readout before being re-injected back into the quantum core. Internal and external calibration loops calculate error syndromes and calibrate the control pulses input to the quantum core.
Type:
Application
Filed:
December 18, 2021
Publication date:
May 5, 2022
Applicant:
equal1.labs Inc.
Inventors:
Dirk Robert Walter Leipold, George Adrian Maxim, Michael Albert Asker
Abstract: The present invention provides a biomaterial assay strip as a strip-type platform for use in a point-of-care test device. The strip includes a porous matrix bearing micropores and composed of materials comprising a copolymer selected from the group comprising polysulfone, polyethersulfone, and polyarylsulfone in order to increase separation efficiency of the blood cells contained in a sample and to improve accuracy and reproducibility of measurements with a small amount of blood, wherein the matrix comprises an enzyme, a dye, and a hydrophilic polymer material therein, which all respond to a biomaterial and wherein the matrix develops a color as the biomaterial contained in the sample which is brought into contact with the upper layer of the matrix and then diffuses to the lower layer of the matrix, thereby assaying the biomaterial.
Abstract: A method, system, and medium are provided for distributing transportation alerts to computing devices in accordance with factors, such as device-specific and location-specific factors. In embodiments of the present invention, travel alerts, including public alerts associated with certain areas, are formatted or held odor to delivery, based on safety concerns, legal requirements, device settings, or other considerations.
Type:
Application
Filed:
January 10, 2022
Publication date:
May 5, 2022
Applicant:
III Holdings 1, LLC
Inventors:
Stephen Haag, Carlos J. Lebrilla, Marc Rush, Linda Rolfes
Abstract: The invention relates to poly(oligo(ethylene glycol) methacrylate) microgels, to the process for preparing same and the uses thereof in various fields of application such as optics, electronics, pharmacy and cosmetics. These microgels have the advantage of being monodisperse, pH-responsive and temperature-responsive. They can carry magnetic nanoparticles or biologically active molecules. These microgels may also form transparent films, which have novel optical and electromechanical properties.
Type:
Grant
Filed:
July 13, 2020
Date of Patent:
May 3, 2022
Assignees:
LVMH RECHERCHE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE PAU ET DES PAYS DE 1'ADOUR
Abstract: A system for locating an implanted device including magnetic coils within a subject is provided. The system includes a magnetic sensor array including a plurality of magnetic sensors, the magnetic sensor array configured to measure a magnetic field generated by the implanted device, and a position detection module communicatively coupled to the magnetic sensor array, the position detection module configured to receive the measured magnetic field from the magnetic sensor array, and calculate a position of the implanted device based on the measured magnetic field.
Type:
Grant
Filed:
December 21, 2020
Date of Patent:
May 3, 2022
Assignee:
TC1 LLC
Inventors:
John Freddy Hansen, Christopher Eskildsen
Abstract: An arrangement configured to introduce a force from a fastening element into a plastic component, the arrangement including a force-limiting element that is embedded in the plastic component; wherein the fastening element is configured to fasten the plastic component at a body; wherein the fastening element is insertable through the force-limiting element, and wherein the plastic component includes a retention device which protrudes at least partially into an interior of the force-limiting element so that the fastening element that is inserted into the force-limiting element is retained in the force limiting element.
Type:
Grant
Filed:
December 14, 2019
Date of Patent:
May 3, 2022
Assignee:
ECO Holding 1 GmbH
Inventors:
Daniel Stanhope, Brent Brower, Matt Carlson, Matt Stolzman