Patents Assigned to Abbott Laboratories
  • Patent number: 10501816
    Abstract: Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: December 10, 2019
    Assignees: ABBOTT LABORATORIES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles Chiu, Deanna Lee, Michael Berg, George Dawson, Kelly Coller, Kevin Cheng, John R. Hackett, Jr., Matthew Frankel, Kenn Forberg
  • Publication number: 20190364939
    Abstract: A pureed nutritional product, a packaged nutritional product containing a pureed nutritional product, and a method of making the pureed nutritional product are provided. The pureed nutritional product includes from 50 wt % to 99.7 wt % of a blend of fruit and vegetable, at least one polyunsaturated fatty acid, at least one carotenoid, and RRR-alpha-tocopherol. The pureed nutritional product has an energy density of 0.4 kcal/g to 0.8 kcal/g. The pureed nutritional product has desirable consistency, texture, and mouthfeel characteristics.
    Type: Application
    Filed: September 21, 2017
    Publication date: December 5, 2019
    Applicant: ABBOTT LABORATORIES
    Inventors: ROCKENDRA GUPTA, GAURAV PATEL, NORMANELLA DEWILLE
  • Patent number: 10488362
    Abstract: Example paper substrate diagnostic apparatus and related methods and systems are disclosed herein. An example apparatus includes a hydrophobic substrate having a first end and a second end opposite the first end. The apparatus includes a detection zone on a first surface of the substrate, the detection zone defining an area to sense an analyte in a sample, the detection zone comprising a first electrode and a second electrode disposed on the first surface of the substrate and a layer of hydrophilic ink disposed on the two electrodes and an area between the first and second electrodes. The apparatus also includes a channel comprising hydrophilic ink disposed on the first surface of the substrate, the channel having an inlet section adjacent the first end of the substrate, a middle section, and an outlet section in contact with the layer of hydrophilic ink. The channel is to transfer a fluid sample from the inlet section to the layer of hydrophilic ink.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: November 26, 2019
    Assignee: ABBOTT LABORATORIES
    Inventor: Sophie Laurenson
  • Patent number: 10481073
    Abstract: Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission to distinguish basophils from other WBC sub-populations. In one embodiment, the systems and methods include performing a basophil cluster analysis of the blood sample, based on the combination of light scatter and fluorescence measurements.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: November 19, 2019
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Michael R. Buhl, Giacomo Vacca
  • Patent number: 10481072
    Abstract: Systems and methods for analyzing blood samples, and more specifically for performing a nucleated red blood cell (nRBC) analysis. The systems and methods screen a blood sample by means of fluorescence staining and a fluorescence triggering strategy, to identify nuclei-containing particles within the blood sample. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder reagent(s), suitable for assays of samples containing fragile white blood cells (WBCs). In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; (b) using a fluorescence trigger to screen the blood sample for nuclei-containing particles; and (c) using measurements of light scatter and fluorescence emission to distinguish nRBCs from WBCs.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 19, 2019
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Marilou Coleman, Emily H. Lin, Michael R. Buhl, Giacomo Vacca
  • Patent number: 10481071
    Abstract: Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (WBC) differential analysis. The systems and methods screen WBCs by means of fluorescence staining and a fluorescence triggering strategy. As such, interference from unlyzed red blood cells (RBCs) and fragments of lysed RBCs is substantially eliminated. The systems and methods also enable development of relatively milder WBC reagent(s), suitable for assays of samples containing fragile WBCs. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye, which corresponds in emission spectrum to an excitation source of a hematology instrument; (b) using a fluorescence trigger to screen the blood sample for WBCs; and (c) using measurements of (1) axial light loss, (2) intermediate angle scatter, (3) 90° polarized side scatter, (4) 90° depolarized side scatter, and (5) fluorescence emission to perform a differentiation analysis.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 19, 2019
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Giacomo Vacca
  • Patent number: 10471081
    Abstract: Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective in reducing inflammation and the incidence of inflammatory diseases.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: November 12, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: JoMay Chow, Steven R. Davis, Rachael Buck, Geralyn O. Duska-McEwen, Hawley K. Linke
  • Publication number: 20190328021
    Abstract: A nutritional supplement powder and a method of making the nutritional supplement powder are provided. The nutritional supplement powder includes from 20% by weight to 55% by weight protein, from 20% by weight to 50% by weight fructooligosaccharide powder, and an anti-caking mixture that includes calcium silicate and tricalcium phosphate. A weight ratio of the fructooligosaccharide powder to the anti-caking mixture is from 6:1 to 10:1.
    Type: Application
    Filed: February 28, 2017
    Publication date: October 31, 2019
    Applicant: ABBOTT LABORATORIES
    Inventors: DEBORAH STROZIER, RONALD MCKENNA, TAMA BLOCH, KUOCHU LI
  • Patent number: 10456786
    Abstract: Example apparatus including septums and related methods are disclosed. An example apparatus includes a septum that includes a first surface and a membrane coupled to at least a portion of the first surface. In addition, the example septum includes a second surface and ribs extending between the membrane and the second surface.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: October 29, 2019
    Assignee: ABBOTT LABORATORIES
    Inventor: Robert P. Luoma, II
  • Patent number: 10444242
    Abstract: The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of HCV core protein and the DNA binding domain antibody or antibody fragment recognizes an epitope in amino acids 95-123 (e.g., in amino acids 99-117) of HCV core protein.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: October 15, 2019
    Assignees: ABBOTT LABORATORIES, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Robert Ziemann, April Ahlberg, David Hawksworth, Bryan Tieman, A. Scott Muerhoff, Christopher Marohnic, Kathy Otis, Andrea Branch, Francis Eng
  • Patent number: 10445876
    Abstract: The instant disclosure provides methods of extracting stain-independent features from digital images of histologically stained cells. Stain-independent features provide consistent assessment of cell morphology in the presence of staining variation and across different stains or stain formulations. Improved consistency in cell morphology assessments finds use in automated cell classification and other image processing applications. Also included are systems for practicing the described methods. The instant disclosure also provides computer readable media storing instructions that, when executed by a computing device, cause the computing device and/or components of a described system to perform steps of a method involving of extraction of stain-independent features from digital images.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: October 15, 2019
    Assignee: Abbott Laboratories
    Inventors: Rene Nieves Alicea, Wenjing Li
  • Patent number: 10420637
    Abstract: Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 24, 2019
    Assignee: Abbott Laboratories Vascular Enterprises Limited
    Inventors: Joost J. Fierens, Silvio R. Schaffner, Marc Gianotti, Gerd Seibold, Randolf von Oepen
  • Patent number: 10421588
    Abstract: A sealed container for packaging of granular or powdered product including a rigid container body defining an interior space and an upper portion, the upper portion having a sealing lip that defines an opening to the interior space, and a flexible, polymer sealing membrane removably attached to the sealing lip to cover the opening, the sealing membrane including a plurality of laser generated micro-perforations formed through the sealing membrane, the size of each of the plurality of laser generated micro-perforations being less than 3.937 mils.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: September 24, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Jason Middleton, Spencer Beaufore, Jeremy McBroom
  • Patent number: 10413295
    Abstract: An engaging element for engaging tissue that includes a first member and a second member. The first member includes at least one tissue engaging portion at a first free end. The first tissue engaging member is movable between an open position and a closed position and has a second free end. The first tissue engaging member is restrained in movement at an intermediate position between the first free end and the second free end. A lock portion is operatively associated with the first member with the lock portion maintaining a spacing between the first member and the second member and inhibiting movement of the first member to the open position. The lock portion is operatively associated with a portion of the first tissue engaging member proximal the intermediate position.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: September 17, 2019
    Assignee: Abbott Laboratories
    Inventor: Arkady Kokish
  • Patent number: 10413288
    Abstract: A device for suturing an opening in a tissue, having an elongated shaft, at least two arms movable to a deployed positioning which the arms are non-perpendicular to the shaft, the arms having needle receiving portions; and needles advanceable longitudinally along the shaft toward the needle receiving portions, the needles exiting through side walls of the shaft at a location proximal to the arms.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: September 17, 2019
    Assignee: Abbott Laboratories
    Inventor: Joshua Stafford
  • Patent number: 10416181
    Abstract: Cradles for draining liquid from containers are described herein. An example apparatus includes a housing having a bottom wall, a side wall and an open top. The housing is to receive a container having liquid. The example apparatus includes a probe extending upward from the bottom wall toward the open top and is to drain the liquid from the container when the probe is inserted into the container. The example apparatus also includes a sliding lock slidably disposed within the housing that receives a cap or top of the container when the container is inserted into the housing. The sliding lock includes a key slot. The sliding lock is movable when a cap or top of the container has a matching key that engages the key slot, which enables the sliding lock to move downward to expose the probe and drain the liquid from the container.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 17, 2019
    Assignee: ABBOTT LABORATORIES
    Inventor: Roger W. Accurso
  • Patent number: 10398716
    Abstract: Disclosed are methods of modulating and/or decreasing serum corticosterone levels in an individual affected by stress. Further disclosed are methods of modulating the hypothalamic pituitary adrenal response in an individual. The methods include administration of 2-fucosyl-lactose to an individual.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: September 3, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Enrique Vazquez Hernandez, Ricardo Rueda Cabrera, Rachael Buck, Maria Ramirez Gonzalez
  • Patent number: D859192
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: September 10, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Christina A. Barton, Rachel Elizabeth Wallace, Ami Marie Verhalen, Daniel Roger Nett
  • Patent number: D868284
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: November 26, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Kyle Demmink, Jeremy McBroom
  • Patent number: D869309
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: December 10, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Christina A. Barton, Sherry Sue Eckholm, Vladlena Belozerova, Ami Marie Verhalen, Jesse Charles Darley